What are the cheapest airlines to fly from Washington, D.C. Reagan-National Airport to South America one-way?

$128 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $128 and $153, respectively.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Washington, D.C. Reagan-National Airport to South America?

The most popular route from Washington, D.C. Reagan-National Airport to South America is Washington, D.C. Reagan-National - Lima J Chavez Intl. You may also consider Washington, D.C. Reagan-National - Medellín Jose Maria Cordova Intl or Washington, D.C. Reagan-National - Buenos Aires Ministro Pistarini.

What are the most popular airlines that fly from Washington, D.C. Reagan-National Airport to South America?

The most popular airlines flying from Washington, D.C. Reagan-National Airport to South America are American Airlines, Delta and LATAM Airlines. Something to consider prior to booking your flight.

What is the cheapest month to fly from Washington, D.C. Reagan-National Airport to South America?

Our data shows that October tends to be the cheapest month to fly to South America from Washington, D.C. Reagan-National Airport. Users have commonly found prices around $774 for the month, but tickets can be as low as $570. Due to multiple factors, prepare for potentially higher prices in December.

Can I find deals for flights from Reagan-National to South America that include hotel bookings?

Yes. In addition to deals on Reagan-National to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Reagan-National to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Reagan-National to South America.

Can I find deals for business class flights from Reagan-National to South America?

Yes. Cheapflights offers flight deals from Reagan-National to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$128+ Flights from Washington, D.C. Reagan-National Airport to South America

Q: How far in advance should I book a flight from Washington, D.C. Reagan-National Airport to South America?

To save up to 16% on this flight, we recommend booking at least 42 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Washington, D.C. Reagan-National Airport to South America from $531 1-2 weeks out and tickets from $573 for flights departing within the next 72 hours.

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Reagan-National to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Reagan-National to South America

Round-trip from	$303 (United Airlines)
One-way from	$128 (United Airlines)
Popular in	December
Cheapest in	October
Average price	$702

From Washington, D.C. Reagan-National to South America

Search Deals

One-way flight from Washington, D.C. Reagan-National to South America

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($124 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($32 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Find flight deals from Reagan-National to South America

Cheapest flights from Reagan-National to South America
Explore the most affordable flight options available from Reagan-National to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Sat 11/112:50 pmDCA - MDE

1 stop9h 15mUnited Airlines

Wed 11/510:45 amMDE - DCA

1 stop10h 00mUnited Airlines

Deal found 9/14

$303

Wed 10/2911:15 amDCA - MDE

2 stops10h 00mAmerican Airlines

Wed 11/57:00 amMDE - DCA

1 stop10h 00mAmerican Airlines

Deal found 9/13

$307

Sun 9/286:00 amDCA - MDE

1 stop16h 10mUnited Airlines

Thu 10/29:45 amMDE - DCA

1 stop29h 17mUnited Airlines

Deal found 9/14

$310

Wed 12/34:34 pmDCA - MDE

1 stop13h 08mUnited Airlines

Sun 12/71:15 amMDE - DCA

1 stop20h 49mUnited Airlines

Deal found 9/15

$315

Sat 10/48:07 pmDCA - MDE

1 stop17h 43mAmerican Airlines

Tue 10/76:00 amMDE - DCA

1 stop13h 16mAmerican Airlines

Deal found 9/14

$318

Tue 10/71:38 pmDCA - MDE

1 stop7h 37mAmerican Airlines

Wed 10/156:00 amMDE - DCA

2 stops12h 58mAmerican Airlines

Deal found 9/15

$322

Wed 9/2411:00 amDCA - MDE

1 stop11h 10mUnited Airlines

Sat 11/810:45 amMDE - DCA

1 stop10h 00mUnited Airlines

Deal found 9/15

$323

Fri 10/316:20 pmDCA - MDE

1 stop19h 15mAmerican Airlines

Sun 11/21:30 amMDE - DCA

1 stop9h 17mAmerican Airlines

Deal found 9/14

$325

Mon 11/37:59 pmDCA - CTG

1 stop17h 27mAmerican Airlines

Sat 11/154:30 pmCTG - DCA

1 stop16h 30mAmerican Airlines

Deal found 9/14

$326

Sat 11/85:58 pmDCA - CTG

1 stop21h 32mAmerican Airlines

Sat 11/154:30 pmCTG - DCA

1 stop16h 30mAmerican Airlines

Deal found 9/13

$334

Tue 9/306:00 amDCA - MDE

1 stop15h 15mAmerican Airlines

Thu 10/26:00 amMDE - DCA

2 stops12h 59mAmerican Airlines

Deal found 9/14

$337

Fri 11/77:59 pmDCA - BOG

1 stop26h 36mUnited Airlines

Mon 11/101:30 amBOG - DCA

1 stop19h 15mUnited Airlines

Deal found 9/13

$338

Best flights from Reagan-National to South America
Discover carefully curated flight deals from Reagan-National to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Thu 11/138:15 amDCA - MDE

1 stop13h 50mUnited Airlines

Tue 11/1810:45 amMDE - DCA

1 stop11h 24mUnited Airlines

Deal found 9/14

$303

Mon 11/35:00 amDCA - CTG

2 stops10h 30mAmerican Airlines

Sat 11/154:30 pmCTG - DCA

2 stops16h 44mAmerican Airlines

Deal found 9/14

$330

Wed 9/247:30 pmDCA - BOG

1 stop24h 45mMultiple Airlines

Sun 9/2810:15 amBOG - DCA

1 stop26h 13mMultiple Airlines

Deal found 9/14

$353

Fri 10/176:00 amDCA - BOG

1 stop14h 15mDelta

Sun 10/191:35 amBOG - DCA

1 stop11h 10mDelta

Deal found 9/13

$353

Thu 11/64:10 pmDCA - GRU

1 stop14h 50mAir Canada

Sun 11/99:45 pmGRU - DCA

1 stop19h 46mAir Canada

Deal found 9/15

$600

Mon 11/108:15 amDCA - MDE

1 stop13h 50mUnited Airlines

Tue 11/1810:45 amMDE - DCA

1 stop10h 00mUnited Airlines

Deal found 9/14

$303

Mon 10/274:03 pmDCA - SDU

2 stops18h 32mLATAM Airlines

Sun 11/98:05 pmSDU - DCA

2 stops17h 25mLATAM Airlines

Deal found 9/15

$615

Tue 11/1112:50 pmDCA - MDE

1 stop9h 15mUnited Airlines

Fri 11/1410:45 amMDE - DCA

1 stop11h 24mUnited Airlines

Deal found 9/14

$303

Sat 11/18:30 pmDCA - CTG

1 stop20h 00mAmerican Airlines

Sat 11/82:26 pmCTG - DCA

1 stop9h 58mAmerican Airlines

Deal found 9/13

$334

Fri 9/266:59 amDCA - BOG

1 stop13h 16mDelta

Sun 9/281:35 amBOG - DCA

1 stop11h 25mDelta

Deal found 9/13

$353

Thu 11/135:15 pmDCA - VCP

2 stops47h 45mGOL

Wed 11/267:40 pmVCP - DCA

2 stops22h 15mGOL

Deal found 9/13

$706

Sat 11/1512:50 pmDCA - MDE

1 stop9h 15mUnited Airlines

Tue 11/1810:45 amMDE - DCA

1 stop10h 00mUnited Airlines

Deal found 9/14

$303

Last-minute flights from Reagan-National to South America
Discover last-minute flight deals from Reagan-National to South America. Data last updated September 15, 2025 and is based on user searches.

Tue 9/1611:00 amDCA - BOG

1 stop9h 20mUnited Airlines

Tue 9/238:30 amBOG - DCA

1 stop11h 23mUnited Airlines

Deal found 9/15

$342

Wed 9/2411:00 amDCA - MDE

1 stop11h 10mUnited Airlines

Sat 11/810:45 amMDE - DCA

1 stop10h 00mUnited Airlines

Deal found 9/15

$323

Sun 9/286:00 amDCA - MDE

1 stop16h 10mUnited Airlines

Thu 10/29:45 amMDE - DCA

1 stop29h 17mUnited Airlines

Deal found 9/14

$310

Tue 9/308:59 amDCA - MDE

2 stops12h 16mAmerican Airlines

Thu 10/26:00 amMDE - DCA

2 stops13h 02mAmerican Airlines

Deal found 9/14

$337

Wed 10/17:59 pmDCA - BOG

1 stop24h 21mUnited Airlines

Sat 10/118:30 amBOG - DCA

1 stop14h 20mUnited Airlines

Deal found 9/14

$338

Sat 10/48:07 pmDCA - MDE

1 stop17h 43mAmerican Airlines

Tue 10/76:00 amMDE - DCA

1 stop13h 16mAmerican Airlines

Deal found 9/14

$318

Mon 10/66:59 amDCA - BOG

1 stop10h 36mLATAM Airlines

Mon 10/132:55 pmBOG - DCA

1 stop17h 15mLATAM Airlines

Deal found 9/13

$343

Tue 10/71:38 pmDCA - MDE

1 stop7h 37mAmerican Airlines

Wed 10/156:00 amMDE - DCA

2 stops12h 58mAmerican Airlines

Deal found 9/15

$322

Fri 10/2410:45 pmDCA - CTG

2 stops14h 40mAmerican Airlines

Fri 10/311:25 pmCTG - DCA

1 stop9h 34mAmerican Airlines

Deal found 9/13

$330

Wed 10/2912:50 pmDCA - MDE

1 stop9h 15mUnited Airlines

Wed 11/510:45 amMDE - DCA

1 stop11h 24mUnited Airlines

Deal found 9/14

$303

Wed 10/2911:15 amDCA - MDE

2 stops10h 00mAmerican Airlines

Wed 11/57:00 amMDE - DCA

1 stop10h 00mAmerican Airlines

Deal found 9/13

$307

Fri 10/316:20 pmDCA - MDE

1 stop19h 15mAmerican Airlines

Sun 11/21:30 amMDE - DCA

1 stop9h 17mAmerican Airlines

Deal found 9/14

$325

One-way flights from Reagan-National to South America
Search for one-way flight options from Reagan-National to South America. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Fri 9/1911:00 amDCA - MDE

1 stop11h 10mUnited Airlines

Deal found 9/15

$128

Sat 12/65:00 amDCA - MDE

1 stop18h 39mAmerican Airlines

Deal found 9/13

$141

Sat 10/255:00 amDCA - CTG

1 stop8h 25mAmerican Airlines

Deal found 9/14

$143

Mon 9/298:59 amDCA - MDE

2 stops12h 16mAmerican Airlines

Deal found 9/13

$143

Thu 9/186:59 amDCA - BOG

2 stops13h 55mLATAM Airlines

Deal found 9/13

$151

Sat 11/156:00 amDCA - CTG

1 stop8h 14mDelta

Deal found 9/13

$153

Thu 9/186:00 amDCA - BOG

1 stop14h 20mUnited Airlines

Deal found 9/14

$153

Tue 11/116:18 pmDCA - BOG

2 stops22h 27mLATAM Airlines

Deal found 9/12

$159

Thu 10/167:59 pmDCA - MDE

1 stop26h 11mUnited Airlines

Deal found 9/14

$161

Sun 10/266:45 amDCA - MDE

1 stop7h 47mJetBlue

Deal found 9/14

$163

Thu 11/206:00 amDCA - MDE

1 stop8h 09mAmerican Airlines

Deal found 9/14

$178

Thu 10/28:20 amDCA - CTG

2 stops25h 22mUnited Airlines

Deal found 9/13

$179

Cheapflights Fare Finder

Use the filters below to find and compare flights from Washington, D.C. Reagan-National Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Thu 11/13

8:15 am-10:05 pm

1 stop13h 50m

Medellín Jose Maria Cordova Intl

Tue 11/18

10:45 am-10:09 pm

1 stop11h 24m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Mon 11/10

8:15 am-10:05 pm

1 stop13h 50m

Medellín Jose Maria Cordova Intl

Tue 11/18

10:45 am-8:45 pm

1 stop10h 00m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Tue 11/11

12:50 pm-10:05 pm

1 stop9h 15m

Medellín Jose Maria Cordova Intl

Fri 11/14

10:45 am-10:09 pm

1 stop11h 24m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Sat 11/15

12:50 pm-10:05 pm

1 stop9h 15m

Medellín Jose Maria Cordova Intl

Tue 11/18

10:45 am-8:45 pm

1 stop10h 00m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Mon 11/3

8:15 am-10:05 pm

1 stop13h 50m

Medellín Jose Maria Cordova Intl

Wed 11/5

10:45 am-8:45 pm

1 stop10h 00m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Mon 11/3

12:50 pm-10:05 pm

1 stop9h 15m

Medellín Jose Maria Cordova Intl

Sat 11/8

10:45 am-8:45 pm

1 stop10h 00m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Mon 11/10

8:15 am-10:05 pm

1 stop13h 50m

Medellín Jose Maria Cordova Intl

Wed 11/19

10:45 am-11:44 pm

1 stop12h 59m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Fri 9/19

12:50 pm-9:10 pm

1 stop9h 20m

Medellín Jose Maria Cordova Intl

Thu 9/25

9:45 am-8:51 pm

1 stop10h 06m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Sun 11/16

12:50 pm-10:05 pm

1 stop9h 15m

Medellín Jose Maria Cordova Intl

Wed 11/19

10:45 am-8:45 pm

1 stop10h 00m

$303

Washington, D.C.Medellín

DCA - MDE

DCAMDE

Washington, D.C. Reagan-National

Tue 9/30

11:00 am-9:10 pm

1 stop11h 10m

Medellín Jose Maria Cordova Intl

Thu 10/2

9:45 am-11:50 pm

1 stop13h 05m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results

...

Best time to book a flight from Reagan-National to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Reagan-National with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Washington, D.C. Reagan-National Airport to South America

What is the cheapest month to book a flight from Washington, D.C. Reagan-National Airport to South America?

Currently, May is the cheapest month in which you can book a flight from Washington, D.C. Reagan-National Airport to South America (average of $359). Flying from Washington, D.C. Reagan-National Airport to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DCA to SA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Washington, D.C. Reagan-National Airport to South America as you normally would.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Washington, D.C. Reagan-National Airport to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,954 reviews

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.6

Good

1,531 reviews

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,847 reviews

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,929 reviews

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,954 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Washington, D.C. Reagan-National Airport to South America?
For as low as $330, United Airlines can have you in South America from Washington, D.C. Reagan-National Airport in 10h 30m. The distance between Washington, D.C. Reagan-National Airport and South America is about 1964 mi. This flight may include one or multiple stops.
What are the cheapest airlines to fly from Washington, D.C. Reagan-National Airport to South America one-way?
$128 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $128 and $153, respectively.
What are the most popular routes from Washington, D.C. Reagan-National Airport to South America?
The most popular route from Washington, D.C. Reagan-National Airport to South America is Washington, D.C. Reagan-National - Lima J Chavez Intl. You may also consider Washington, D.C. Reagan-National - Medellín Jose Maria Cordova Intl or Washington, D.C. Reagan-National - Buenos Aires Ministro Pistarini.
Can I find deals for flights from Reagan-National to South America that include hotel bookings?
Yes. In addition to deals on Reagan-National to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Reagan-National to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Reagan-National to South America.
Can I find deals for business class flights from Reagan-National to South America?
Yes. Cheapflights offers flight deals from Reagan-National to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Washington, D.C. Reagan-National Airport to South America?
Currently, May is the cheapest month in which you can book a flight from Washington, D.C. Reagan-National Airport to South America (average of $359). Flying from Washington, D.C. Reagan-National Airport to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from Reagan-National to South America

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$283	Average$731	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$288	Average$648	FlexibilityNo cancel fee	On-time81%
Copa Airlines	Cheapest$290	Average$502	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$302	Average$662	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$303	Average$765	FlexibilityNo cancel fee	On-time71%
Avianca	Cheapest$382	Average$585	FlexibilityNo cancel fee	On-time71%
Air Canada	Cheapest$588	Average$741	FlexibilityNo cancel fee	On-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$128+ Cheap flights from Reagan-National (DCA) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Reagan-National to South America with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Reagan-National to South America

Keep the following information in mind while searching for Reagan-National to South America flight deals. Data was last updated September 15, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Reagan-National to South America

Cheapest flights from Reagan-National to South AmericaExplore the most affordable flight options available from Reagan-National to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from Reagan-National to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Washington, D.C. Reagan-National Airport to South America that are best for you.

Best time to book a flight from Reagan-National to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Reagan-National with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Washington, D.C. Reagan-National Airport to South America

What is the cheapest month to book a flight from Washington, D.C. Reagan-National Airport to South America?

What is the cheapest time of day to fly from DCA to SA?

Find hourly flight availability from Reagan-National to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Washington, D.C. Reagan-National Airport to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Reagan-National to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Washington, D.C. Reagan-National Airport to South America?

What are the cheapest airlines to fly from Washington, D.C. Reagan-National Airport to South America one-way?

What are the most popular routes from Washington, D.C. Reagan-National Airport to South America?

Can I find deals for flights from Reagan-National to South America that include hotel bookings?

How can I find direct flights from Reagan-National to South America?

Can I find deals for business class flights from Reagan-National to South America?

What is the cheapest month to book a flight from Washington, D.C. Reagan-National Airport to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Reagan-National to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Reagan-National to South America

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Reagan-National to South America
Explore the most affordable flight options available from Reagan-National to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.