HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$323+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/26. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated July 29, 2025.

Round-trip from

$533
(United Airlines)

One-way from

$323
(Delta)
From Panama City NW Florida Beaches to South America
Search Deals
One-way flight from Panama City NW Florida Beaches to South America
Search Deals

Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/105:06 pmECP - BOG
1 stop11h 48mUnited Airlines
Tue 9/1612:14 amBOG - ECP
1 stop9h 39mUnited Airlines
Deal found 7/27$533
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1111:09 amECP - GYE
2 stops24h 06mUnited Airlines
Thu 9/181:11 pmGYE - ECP
2 stops31h 05mUnited Airlines
Deal found 7/28$536
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/21:25 pmECP - BGA
2 stops39h 53mDelta
Wed 11/510:40 pmBGA - ECP
2 stops35h 04mDelta
Deal found 7/26$551
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/103:07 pmECP - BOG
2 stops21h 58mAmerican Airlines
Wed 9/172:10 pmBOG - ECP
2 stops19h 32mAmerican Airlines
Deal found 7/27$552
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/109:24 amECP - BOG
2 stops10h 34mDelta
Tue 9/161:35 amBOG - ECP
2 stops14h 16mDelta
Deal found 7/27$567
This United deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/316:30 amECP - BOG
2 stops22h 24mMultiple Airlines
Sat 9/612:14 amBOG - ECP
2 stops36h 56mMultiple Airlines
Deal found 7/28$804
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/112:00 pmECP - TRU
2 stops21h 55mDelta
Thu 11/1310:35 pmTRU - ECP
2 stops44h 33mDelta
Deal found 7/28$900
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/62:00 pmECP - CUZ
2 stops44h 40mDelta
Tue 12/99:30 pmCUZ - ECP
2 stops26h 13mDelta
Deal found 7/28$944
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:00 pmECP - COR
2 stops33h 50mDelta
Thu 11/137:55 amCOR - ECP
2 stops29h 20mDelta
Deal found 7/27$1,192
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2011:56 amECP - CUZ
3 stops19h 28mAmerican Airlines
Fri 10/34:52 pmCUZ - ECP
3 stops21h 27mAmerican Airlines
Deal found 7/26$2,860

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 9/10

5:06 pm-4:54 am

1 stop11h 48m

Bogotá El Dorado

Tue 9/16

12:14 am-9:53 am

1 stop9h 39m

$533

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 9/11

11:09 am-11:15 am

2 stops24h 06m

Guayaquil Jose Joaquin de Olmedo

Thu 9/18

1:11 pm-8:16 pm

2 stops31h 05m

$536

Panama CityBucaramanga

ECP - BGA

ECPBGA

Panama City NW Florida Beaches

Sun 11/2

1:25 pm-6:18 am

2 stops39h 53m

Bucaramanga Palo Negro

Wed 11/5

10:40 pm-8:44 am

2 stops35h 04m

$551

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 9/10

3:07 pm-1:05 pm

2 stops21h 58m

Bogotá El Dorado

Wed 9/17

2:10 pm-9:42 am

2 stops19h 32m

$552

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 9/10

9:24 am-7:58 pm

2 stops10h 34m

Bogotá El Dorado

Tue 9/16

1:35 am-3:51 pm

2 stops14h 16m

$567

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 8/31

6:30 am-4:54 am

2 stops22h 24m

Bogotá El Dorado

Sat 9/6

12:14 am-1:10 pm

2 stops36h 56m

$804

Panama CityTrujillo

ECP - TRU

ECPTRU

Panama City NW Florida Beaches

Tue 11/11

2:00 pm-12:55 pm

2 stops21h 55m

Trujillo

Thu 11/13

10:35 pm-6:08 pm

2 stops44h 33m

$900

Panama CityCusco

ECP - CUZ

ECPCUZ

Panama City NW Florida Beaches

Sat 12/6

2:00 pm-11:40 am

2 stops44h 40m

Cusco Velazco Astete

Tue 12/9

9:30 pm-10:43 pm

2 stops26h 13m

$944

Panama CityCordoba

ECP - COR

ECPCOR

Panama City NW Florida Beaches

Sun 11/9

5:00 pm-5:50 am

2 stops33h 50m

Cordoba Pajas Blancas

Thu 11/13

7:55 am-10:15 am

2 stops29h 20m

$1,192

Panama CityCusco

ECP - CUZ

ECPCUZ

Panama City NW Florida Beaches

Sat 9/20

11:56 am-7:24 am

3 stops19h 28m

Cusco Velazco Astete

Fri 10/3

4:52 pm-2:19 pm

3 stops21h 27m

$2,860

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 12 results
1
2

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 29, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Panama City to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Bogotá El Dorado, Panama City NW Florida Beaches - Cusco Velazco Astete and Panama City NW Florida Beaches - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to South America

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Newark flights
Miami to John F Kennedy Intl flights
Fort Lauderdale to LaGuardia flights
Orlando to Luis Munoz Marin Intl flights
Miami to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Miami to LaGuardia flights
Fort Lauderdale to Las Vegas flights
Orlando to Dallas/Fort Worth flights
Orlando to Las Vegas flights
Miami to Jose Maria Cordova Intl flights
Miami to Madrid flights
Orlando to Newark flights
Tampa to Newark flights
Orlando to LaGuardia flights
Tampa to John F Kennedy Intl flights
Fort Lauderdale to Luis Munoz Marin Intl flights
Tampa to Las Vegas flights
Miami to Luis Munoz Marin Intl flights
Tampa to Seattle flights
Orlando to Seattle flights
Fort Lauderdale to Jose Maria Cordova Intl flights
West Palm Beach to John F Kennedy Intl flights
Tampa to LaGuardia flights
Tampa to Denver flights
Tampa to Boston flights
Miami to Ministro Pistarini flights
Fort Lauderdale to O'Hare Intl flights
Orlando to Denver flights
Tampa to Luis Munoz Marin Intl flights
Orlando to O'Hare Intl flights
Miami to Cancún flights
Tampa to Sky Harbor Intl flights
Fort Lauderdale to Dallas/Fort Worth flights
Fort Lauderdale to Los Angeles flights
Miami to Denver flights
Miami to Dallas/Fort Worth flights
Miami to Los Angeles flights
Miami to O'Hare Intl flights
Miami to Mexico City flights
Fort Lauderdale to Denver flights
Orlando to Cancún flights
Miami to Heathrow flights
Miami to Barcelona-El Prat flights
Fort Lauderdale to Boston flights
Miami to Panama City flights
Fort Lauderdale to Atlanta flights
Jacksonville to Newark flights
Miami to Leonardo da Vinci/Fiumicino flights

Top 2 airlines flying from Panama City to South America

Discover the top 2 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$448Average$584FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$636FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.