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South America

$313+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated October 28, 2025.

Round-trip from

$513
(Delta)

One-way from

$313
(Delta)
From Panama City NW Florida Beaches to South America
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One-way flight from Panama City NW Florida Beaches to South America
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This LATAM Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amECP - BOG
2 stops10h 45mMultiple Airlines
Mon 11/310:55 amBOG - ECP
2 stops13h 15mMultiple Airlines
Deal found 10/27$608
This LATAM Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:00 pmECP - BOG
2 stops23h 45mMultiple Airlines
Wed 11/510:55 amBOG - ECP
2 stops13h 15mMultiple Airlines
Deal found 10/27$615
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:09 pmECP - BOG
2 stops19h 31mAmerican Airlines
Fri 2/2011:55 pmBOG - ECP
1 stop13h 14mAmerican Airlines
Deal found 10/26$808
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:47 amECP - BOG
1 stop15h 43mAmerican Airlines
Mon 11/1011:55 pmBOG - ECP
1 stop15h 54mAmerican Airlines
Deal found 10/27$834
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:00 amECP - BGA
2 stops15h 01mDelta
Wed 11/56:45 amBGA - ECP
2 stops17h 25mDelta
Deal found 10/26$871
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:32 amECP - BOG
1 stop16h 48mAmerican Airlines
Thu 11/611:55 pmBOG - ECP
1 stop15h 54mAmerican Airlines
Deal found 10/26$891
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3010:04 amECP - BOG
1 stop12h 31mUnited Airlines
Mon 11/38:15 amBOG - ECP
1 stop14h 34mUnited Airlines
Deal found 10/27$893
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:32 amECP - BOG
2 stops15h 38mAmerican Airlines
Mon 11/311:55 pmBOG - ECP
1 stop15h 54mAmerican Airlines
Deal found 10/27$898
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3110:04 amECP - BOG
1 stop19h 06mUnited Airlines
Mon 11/31:30 amBOG - ECP
1 stop15h 33mUnited Airlines
Deal found 10/26$903
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:32 amECP - BOG
2 stops15h 38mAmerican Airlines
Tue 11/43:15 pmBOG - ECP
2 stops21h 14mAmerican Airlines
Deal found 10/26$908
This United deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/12:22 pmECP - BGA
2 stops18h 28mMultiple Airlines
Tue 11/410:40 amBGA - ECP
2 stops30h 23mMultiple Airlines
Deal found 10/26$915
This United deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:30 amECP - BOG
2 stops21h 25mMultiple Airlines
Sun 11/91:30 amBOG - ECP
1 stop13h 27mMultiple Airlines
Deal found 10/27$927

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Thu 4/2

7:45 am-7:30 pm

1 stop11h 45m

Bogotá El Dorado

Mon 4/6

2:55 pm-8:20 am

1 stop17h 25m

$513

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Mon 2/2

3:27 pm-2:15 pm

2 stops21h 48m

Bogotá El Dorado

Mon 2/16

3:15 pm-11:59 am

2 stops21h 44m

$530

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Thu 4/2

12:55 pm-4:54 am

1 stop15h 59m

Bogotá El Dorado

Sun 4/5

12:14 am-12:37 pm

1 stop12h 23m

$549

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Thu 4/2

12:40 pm-9:56 pm

1 stop9h 16m

Bogotá El Dorado

Mon 4/6

2:45 pm-9:24 am

2 stops18h 39m

$554

Panama CityTrujillo

ECP - TRU

ECPTRU

Panama City NW Florida Beaches

Mon 12/8

10:00 am-12:55 pm

2 stops25h 55m

Trujillo

Thu 12/11

9:15 pm-11:06 pm

2 stops26h 51m

$951

Panama CityCusco

ECP - CUZ

ECPCUZ

Panama City NW Florida Beaches

Sat 12/6

1:32 pm-11:10 am

2 stops20h 38m

Cusco Velazco Astete

Tue 12/9

7:50 pm-12:47 pm

2 stops17h 57m

$1,120

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Fri 12/12

6:30 am-5:36 pm

2 stops34h 06m

Guayaquil Jose Joaquin de Olmedo

Fri 12/19

2:35 pm-1:27 pm

2 stops47h 52m

$1,158

Panama CityBelém

ECP - BEL

ECPBEL

Panama City NW Florida Beaches

Tue 3/24

1:30 pm-11:05 am

2 stops19h 35m

Belém Val De Cans

Thu 3/26

2:05 pm-10:17 am

2 stops22h 12m

$1,347

Panama CityBelém

ECP - BEL

ECPBEL

Panama City NW Florida Beaches

Tue 3/24

11:15 am-4:25 pm

2 stops27h 10m

Belém Val De Cans

Fri 3/27

5:10 pm-8:20 am

2 stops41h 10m

$1,394

Panama CityCordoba

ECP - COR

ECPCOR

Panama City NW Florida Beaches

Sun 11/9

6:40 pm-5:50 am

2 stops32h 10m

Cordoba Pajas Blancas

Thu 11/13

7:55 am-11:07 pm

2 stops18h 12m

$1,664

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $196). Flying from Panama City, Florida to South America in June is currently the most expensive (average of $531). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

When flying from Panama City, Florida to South America, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 28, 2025.
Read reviews from past customers who have flown Delta from Panama City to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • How long is the flight from Panama City, Florida to South America?

    A quick flight from Panama City, Florida to South America can take about 11h 45m. Delta provides one of the quickest options available for as low as $513. Airlines will cover a distance of 1927 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Panama City, Florida to South America one-way?

    $313 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $313 and $529, respectively.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Bogotá El Dorado, Panama City NW Florida Beaches - Belém Val De Cans and Panama City NW Florida Beaches - Bucaramanga Palo Negro.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $196). Flying from Panama City, Florida to South America in June is currently the most expensive (average of $531). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Panama City to South America

Discover the top airline that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$482Average$717FlexibilityNo cancel feeOn-timeN/A

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