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South America

$323+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated September 11, 2025.

Round-trip from

$547
(American Airlines)

One-way from

$323
(United Airlines)
From Panama City NW Florida Beaches to South America
Search Deals
One-way flight from Panama City NW Florida Beaches to South America
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:46 amECP - BOG
1 stop15h 44mAmerican Airlines
Wed 1/144:05 pmBOG - ECP
2 stops23h 14mAmerican Airlines
Deal found 9/10$547
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:30 amECP - BOG
1 stop22h 40mUnited Airlines
Sun 11/28:15 amBOG - ECP
1 stop14h 34mUnited Airlines
Deal found 9/11$562
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:10 amECP - BOG
1 stop12h 05mDelta
Mon 10/135:15 pmBOG - ECP
2 stops15h 29mDelta
Deal found 9/10$578
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/103:03 pmECP - BOG
1 stop13h 51mUnited Airlines
Sun 10/1212:14 amBOG - ECP
1 stop9h 38mUnited Airlines
Deal found 9/10$581
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amECP - BOG
1 stop13h 15mDelta
Wed 10/151:35 amBOG - ECP
2 stops13h 45mDelta
Deal found 9/11$582
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:10 amECP - BOG
1 stop12h 05mDelta
Fri 10/172:55 pmBOG - ECP
1 stop8h 15mDelta
Deal found 9/10$583
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/102:40 pmECP - BOG
2 stops22h 25mAmerican Airlines
Sun 10/1212:25 amBOG - ECP
1 stop10h 33mAmerican Airlines
Deal found 9/10$585
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:32 amECP - BOG
1 stop16h 48mAmerican Airlines
Sat 11/112:05 amBOG - ECP
1 stop13h 23mAmerican Airlines
Deal found 9/11$591
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:00 amECP - BOG
1 stop12h 15mDelta
Sat 9/272:55 pmBOG - ECP
1 stop17h 13mDelta
Deal found 9/11$594
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:00 amECP - BGA
2 stops23h 18mDelta
Wed 11/56:55 amBGA - ECP
2 stops26h 49mDelta
Deal found 9/10$615
This United deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:00 pmECP - GYE
2 stops22h 55mMultiple Airlines
Mon 11/103:35 pmGYE - ECP
2 stops25h 28mMultiple Airlines
Deal found 9/10$639
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1911:00 amECP - BGA
2 stops18h 48mDelta
Mon 9/2912:23 pmBGA - ECP
2 stops10h 40mDelta
Deal found 9/9$706

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Tue 12/30

6:46 am-11:30 pm

1 stop15h 44m

Bogotá El Dorado

Wed 1/14

4:05 pm-2:19 pm

2 stops23h 14m

$547

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 10/26

6:30 am-5:10 am

1 stop22h 40m

Bogotá El Dorado

Sun 11/2

8:15 am-9:49 pm

1 stop14h 34m

$562

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Fri 10/10

9:29 am-7:15 pm

1 stop9h 46m

Bogotá El Dorado

Mon 10/13

2:55 pm-11:10 pm

1 stop8h 15m

$578

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sat 10/11

6:00 am-7:15 pm

1 stop13h 15m

Bogotá El Dorado

Thu 10/16

2:55 pm-8:44 am

1 stop17h 49m

$578

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Fri 10/10

3:03 pm-4:54 am

1 stop13h 51m

Bogotá El Dorado

Sun 10/12

12:14 am-9:52 am

1 stop9h 38m

$581

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Fri 10/10

6:32 am-10:30 pm

1 stop15h 58m

Bogotá El Dorado

Sun 10/12

12:25 am-10:58 am

1 stop10h 33m

$581

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Fri 10/10

6:00 am-7:15 pm

1 stop13h 15m

Bogotá El Dorado

Fri 10/17

5:00 am-11:10 pm

2 stops18h 10m

$583

Panama CityBucaramanga

ECP - BGA

ECPBGA

Panama City NW Florida Beaches

Sun 11/2

5:00 am-5:18 am

2 stops23h 18m

Bucaramanga Palo Negro

Wed 11/5

6:55 am-8:44 am

2 stops26h 49m

$615

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 11/6

3:00 pm-2:55 pm

2 stops22h 55m

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

3:35 pm-4:03 pm

2 stops25h 28m

$639

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Fri 10/3

6:30 am-11:15 am

2 stops28h 45m

Guayaquil Jose Joaquin de Olmedo

Tue 10/7

12:15 pm-9:52 am

2 stops21h 37m

$719

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 20 results
1
2

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta and United Airlines from Panama City to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • How long is the flight from Panama City, Florida to South America?

    A quick flight from Panama City, Florida to South America can take about 9h 46m. American Airlines provides one of the quickest options available for as low as $578. Airlines will cover a distance of 1927 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Bogotá El Dorado, Panama City NW Florida Beaches - La Paz El Alto Intl and Panama City NW Florida Beaches - Bucaramanga Palo Negro.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to South America

Discover the top 2 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$448Average$584FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$636FlexibilityNo cancel feeOn-timeN/A

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