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South America

$313+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Panama City to South America

Best flights from Panama City to South America
Discover carefully curated flight deals from Panama City to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/251:34 pmECP - BOG
2 stops23h 41mAmerican Airlines
Sun 2/13:15 pmBOG - ECP
2 stops22h 49mAmerican Airlines
Deal found 12/10$559
This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:30 amECP - BGA
2 stops12h 09mUnited Airlines
Wed 2/187:00 amBGA - ECP
2 stops39h 56mUnited Airlines
Deal found 12/8$569
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/256:09 pmECP - BOG
1 stop19h 16mDelta
Sun 2/19:00 amBOG - ECP
1 stop11h 50mDelta
Deal found 12/10$578
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/246:30 amECP - GYE
2 stops13h 16mUnited Airlines
Tue 1/272:35 pmGYE - ECP
2 stops26h 37mUnited Airlines
Deal found 12/9$659

Find flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated December 12, 2025.

Round-trip from

$523
(Delta)

One-way from

$313
(Delta)
From Panama City NW Florida Beaches to South America
Search Deals
One-way flight from Panama City NW Florida Beaches to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 1/25

1:34 pm-2:15 pm

2 stops23h 41m

Bogotá El Dorado

Sun 2/1

3:15 pm-1:04 pm

2 stops22h 49m

$559

Panama CityBucaramanga

ECP - BGA

ECPBGA

Panama City NW Florida Beaches

Sat 2/14

6:30 am-7:39 pm

2 stops12h 09m

Bucaramanga Palo Negro

Wed 2/18

7:00 am-9:56 pm

2 stops39h 56m

$569

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 1/25

6:09 pm-2:25 pm

1 stop19h 16m

Bogotá El Dorado

Sun 2/1

9:00 am-7:50 pm

1 stop11h 50m

$578

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 1/24

6:30 am-8:46 pm

2 stops13h 16m

Guayaquil Jose Joaquin de Olmedo

Tue 1/27

2:35 pm-4:12 pm

2 stops26h 37m

$659

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Tue 3/10

7:00 am-4:45 pm

2 stops9h 45m

$313

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Tue 3/10

6:00 am-2:33 pm

1 stop8h 33m

$313

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Tue 3/10

2:00 pm-1:15 pm

2 stops23h 15m

$313

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 1/4

4:09 pm-2:15 pm

2 stops21h 06m

$337

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sun 1/4

6:15 am-10:35 pm

1 stop15h 20m

$379

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sun 12/28

4:45 pm-5:36 pm

2 stops47h 51m

$430

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $196). Flying from Panama City, Florida to South America in June is currently the most expensive (average of $531). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Panama City, Florida to South America, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated December 12, 2025.
Read reviews from past customers who have flown Delta and United Airlines from Panama City to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • How long is the flight from Panama City, Florida to South America?

    A quick flight from Panama City, Florida to South America can take about 12h 09m. American Airlines provides one of the quickest options available for as low as $569. Airlines will cover a distance of 1800 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Guayaquil Jose Joaquin de Olmedo, Panama City NW Florida Beaches - Bogotá El Dorado and Panama City NW Florida Beaches - Belém Val De Cans.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $196). Flying from Panama City, Florida to South America in June is currently the most expensive (average of $531). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Panama City to South America

Discover the top airline that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$482Average$755FlexibilityNo cancel feeOn-timeN/A

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