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South America

$102+ Cheap flights from Durham, NC to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — BOG
Jan 14 — Jan 211
Mi 1/14
Mi 1/21
1 adult, Economy
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Cheap flight deals from Durham to South America

Cheapest flights from Durham to South America
Explore the most affordable flight options available from Durham to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Dezember 15, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 12/245:50 pmRDU - MDE
1 stop7h 38mSpirit Airlines
Mo 12/292:25 amMDE - RDU
1 stop14h 30mSpirit Airlines
Deal found 12/14$390
This KAYAK deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/295:50 pmRDU - BOG
1 stop7h 22mSpirit Airlines
Do 1/153:06 pmBOG - RDU
1 stop23h 07mSpirit Airlines
Deal found 12/13$413
This Cheapflightsfares deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 12/305:50 pmRDU - MDE
1 stop7h 38mSpirit Airlines
Di 1/62:25 amMDE - RDU
1 stop14h 30mSpirit Airlines
Deal found 12/14$467
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 12/1411:24 amRDU - CTG
1 stop10h 06mAmerican Airlines
So 12/218:00 amCTG - RDU
1 stop16h 33mAmerican Airlines
Deal found 12/13$504
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/158:14 pmRDU - CTG
2 stops36h 27mMultiple Airlines
So 12/212:15 pmCTG - RDU
1 stop26h 40mMultiple Airlines
Deal found 12/14$510
This Cheapflightsfares deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 12/305:50 pmRDU - MDE
1 stop7h 38mSpirit Airlines
Mo 1/52:25 amMDE - RDU
1 stop14h 30mSpirit Airlines
Deal found 12/13$510
This eDestinos deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/155:50 pmRDU - MDE
1 stop7h 19mSpirit Airlines
Mo 12/222:25 amMDE - RDU
1 stop14h 30mSpirit Airlines
Deal found 12/13$522
This LATAM Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/157:15 amRDU - LIM
1 stop14h 05mLATAM Airlines
Do 12/2511:40 pmLIM - RDU
1 stop10h 35mLATAM Airlines
Deal found 12/13$525
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/158:14 pmRDU - CTG
2 stops36h 27mMultiple Airlines
Sa 12/202:15 pmCTG - RDU
1 stop26h 40mMultiple Airlines
Deal found 12/14$531
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/225:00 amRDU - CTG
2 stops16h 30mAmerican Airlines
Mi 12/318:00 amCTG - RDU
1 stop16h 33mAmerican Airlines
Deal found 12/14$533
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 12/306:14 pmRDU - LIM
1 stop20h 26mMultiple Airlines
Di 1/2011:33 pmLIM - RDU
2 stops24h 18mMultiple Airlines
Deal found 12/13$545
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/156:20 amRDU - MDE
2 stops15h 45mUnited Airlines
Di 12/2310:45 amMDE - RDU
1 stop28h 56mUnited Airlines
Deal found 12/13$545

Find flight deals from Durham to South America

Keep the following information in mind while searching for Durham to South America flight deals. Data was last updated Dezember 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$248
(Copa Airlines)

One-way from

$102
(Copa Airlines)

Popular in

December

Cheapest in

April

Average price

$774
Provider with most accurate pricing for Raleigh-Durham-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Sao Paulo (SAO) flights.
Search Deals
From Durham to South America
Search Deals
One-way flight from Durham to South America
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($52 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Dezember 15, 2025.
Use the filters below to find and compare flights from Durham to South America that are best for you.

Fly from

Durham

Fly to

South America

Route

Depart

Return

Price

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Mi 3/4

3:14 pm-8:41 am

1 stop17h 27m

Cartagena Rafael Nunez

Mo 3/9

6:25 am-2:23 pm

1 stop6h 58m

$256

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Mi 3/4

3:14 pm-8:41 am

1 stop17h 27m

Cartagena Rafael Nunez

So 3/8

6:25 am-2:23 pm

1 stop6h 58m

$271

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

So 1/11

3:09 pm-8:18 am

1 stop17h 09m

Medellín Jose Maria Cordova Intl

Fr 1/30

6:26 am-1:15 pm

1 stop6h 49m

$276

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Do 1/29

5:14 pm-1:30 pm

2 stops20h 16m

Cartagena Rafael Nunez

Do 2/5

4:30 pm-11:59 pm

1 stop7h 29m

$291

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Mi 1/28

6:00 am-3:30 pm

2 stops9h 30m

Cartagena Rafael Nunez

Fr 1/30

4:30 pm-9:55 am

2 stops17h 25m

$291

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sa 5/9

7:20 pm-12:10 pm

2 stops17h 50m

Cartagena Rafael Nunez

Sa 5/16

3:25 pm-9:59 am

2 stops17h 34m

$291

RaleighBogotá

RDU - BOG

RDUBOG

Raleigh-Durham

Sa 1/24

6:15 am-10:35 pm

2 stops16h 20m

Bogotá El Dorado

Di 1/27

8:15 am-11:44 pm

2 stops15h 29m

$294

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Mo 2/2

7:00 am-2:55 pm

1 stop7h 55m

Medellín Jose Maria Cordova Intl

Fr 2/6

2:25 pm-10:59 pm

1 stop8h 34m

$297

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Do 2/5

7:54 pm-3:30 pm

1 stop19h 36m

Cartagena Rafael Nunez

Mo 2/9

4:30 pm-12:17 pm

2 stops19h 47m

$298

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Mi 2/18

3:12 pm-8:18 am

1 stop17h 06m

Medellín Jose Maria Cordova Intl

So 2/22

6:25 am-1:14 pm

1 stop6h 49m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 60 results
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Best time to book a flight from Durham to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to South America

What is the cheapest month to book a flight from Durham to South America?

Currently, November is the cheapest month in which you can book a flight from Durham to South America (average of $172). Flying from Durham to South America in December is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to SA?

Find hourly flight availability from Durham to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Dezember 15, 2025.

It’s typically best to fly out from Durham to South America in the afternoon. Doing so could potentially save you 7% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from Durham to South America?

Use this chart to determine the cheapest time to fly round-trip from Durham to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Durham to South America flight should consider departing on Tuesday at noon when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated Dezember 15, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Durham to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Copa Airlines
7.6
Good
1,557 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,892 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Durham to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Durham to South America?

    There are many flights that can get you from Durham to South America in 16h 20m. Fly via Copa Airlines, American Airlines, or United Airlines to get the fastest option. Durham and South America are separated by a distance of 2173 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Durham to South America one-way?

    The cheapest airlines for a one-way flight from Durham to South America are Copa Airlines ($103), Spirit Airlines ($103), and American Airlines ($128).

  • What are the most popular routes from Durham to South America?

    While some choose either Raleigh-Durham - Bogotá El Dorado or Raleigh-Durham - Cartagena Rafael Nunez, Raleigh-Durham - Medellín Jose Maria Cordova Intl is the most popular route from Durham to South America.

  • Can I find deals for flights from Durham to South America that include hotel bookings?

    Yes. In addition to deals on Durham to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to South America.

  • Can I find deals for business class flights from Durham to South America?

    Yes. Cheapflights offers flight deals from Durham to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to South America?

    Currently, November is the cheapest month in which you can book a flight from Durham to South America (average of $172). Flying from Durham to South America in December is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Durham to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from Durham to South America

Discover the top 8 airlines that operate flights from Durham to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Dezember 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$708FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$225Average$621FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$245Average$645FlexibilityNo cancel feeOn-time70%
Spirit AirlinesCheapest$261Average$594FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$283Average$724FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$297Average$456FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$314Average$612FlexibilityNo cancel feeOn-time69%
GOLCheapest$540Average$1,211FlexibilityNo cancel feeOn-time74%

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