How long is the flight from Charleston to South America?

Airlines like Spirit Airlines, JetBlue, and Delta fly from Charleston to South America in about 17h 06m. The time it takes to get you to your destination can typically vary by up to 2h 22m. Charleston and South America are separated by a distance of 1983 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Charleston to South America?

Most travelers choose Charleston - Medellín Jose Maria Cordova Intl, Charleston - Bogotá El Dorado or Charleston - Lima J Chavez Intl when deciding on the best route from Charleston to South America.

What are the most popular airlines that fly from Charleston to South America?

Consider American Airlines, Delta or LATAM Airlines when booking your flight. These represent the most popular airlines when flying from Charleston to South America.

What airport do you fly from for flights from Charleston to South America?

For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

Can I find deals for flights from Charleston to South America that include hotel bookings?

Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Charleston to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

Can I find deals for business class flights from Charleston to South America?

Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$133+ Flights from Charleston to South America

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Find flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2025.

Mon 11/107:00 amCHS - CTG

1 stop6h 15mSpirit Airlines

Mon 11/242:30 pmCTG - CHS

1 stop7h 35mSpirit Airlines

Deal found 10/9

$256

Fri 12/55:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Wed 12/102:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$285

Thu 12/45:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Wed 12/102:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$298

Fri 12/55:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Mon 12/82:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$304

Thu 12/45:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Mon 12/82:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$318

Fri 12/55:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Thu 12/112:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$335

Thu 12/45:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Thu 12/112:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$349

Thu 10/2310:11 amCHS - CTG

1 stop27h 14mSpirit Airlines

Fri 10/311:32 pmCTG - CHS

2 stops28h 09mSpirit Airlines

Deal found 10/9

$353

Thu 12/48:53 pmCHS - CTG

2 stops16h 15mMultiple Airlines

Mon 12/82:16 pmCTG - CHS

1 stop20h 29mMultiple Airlines

Deal found 10/7

$362

Mon 11/37:00 amCHS - BOG

1 stop7h 10mSpirit Airlines

Fri 11/283:17 pmBOG - CHS

1 stop6h 48mSpirit Airlines

Deal found 10/9

$402

Thu 10/3010:11 amCHS - BOG

2 stops14h 44mMultiple Airlines

Mon 11/31:55 pmBOG - CHS

1 stop18h 42mMultiple Airlines

Deal found 10/7

$440

Mon 11/38:00 amCHS - BOG

2 stops14h 10mAmerican Airlines

Fri 11/288:00 amBOG - CHS

2 stops14h 24mAmerican Airlines

Deal found 10/9

$598

Best flights from Charleston to South America
Discover carefully curated flight deals from Charleston to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2025.

Fri 12/55:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Mon 12/82:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$304

Thu 12/48:53 pmCHS - CTG

2 stops16h 15mMultiple Airlines

Mon 12/82:16 pmCTG - CHS

1 stop20h 29mMultiple Airlines

Deal found 10/7

$362

Mon 3/26:19 pmCHS - MDE

2 stops19h 01mJetBlue

Fri 3/62:25 pmMDE - CHS

1 stop25h 23mJetBlue

Deal found 10/8

$499

Tue 3/107:59 pmCHS - BOG

2 stops17h 06mDelta

Wed 3/182:55 pmBOG - CHS

1 stop17h 54mDelta

Deal found 10/7

$523

Tue 3/107:45 amCHS - BOG

1 stop12h 45mLATAM Airlines

Wed 3/189:00 amBOG - CHS

1 stop12h 03mLATAM Airlines

Deal found 10/9

$523

Thu 2/269:37 amCHS - MDE

1 stop13h 47mAmerican Airlines

Sun 3/83:15 pmMDE - CHS

1 stop18h 02mAmerican Airlines

Deal found 10/8

$542

Thu 2/265:10 pmCHS - MDE

1 stop28h 55mUnited Airlines

Sun 3/89:45 amMDE - CHS

3 stops28h 39mUnited Airlines

Deal found 10/8

$557

Mon 12/85:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Thu 12/112:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$335

Sun 12/75:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Thu 12/112:16 pmCTG - CHS

1 stop20h 29mSpirit Airlines

Deal found 10/7

$349

Mon 12/85:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Sat 12/137:41 amCTG - CHS

2 stops27h 04mMultiple Airlines

Deal found 10/7

$404

Sat 12/65:40 pmCHS - CTG

1 stop19h 28mSpirit Airlines

Thu 12/112:16 pmCTG - CHS

2 stops18h 18mSpirit Airlines

Deal found 10/7

$364

Sat 12/65:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Sat 12/137:41 amCTG - CHS

2 stops27h 04mMultiple Airlines

Deal found 10/7

$404

Mon 12/85:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Fri 12/126:55 pmCTG - CHS

2 stops21h 50mMultiple Airlines

Deal found 10/7

$409

Mon 11/37:00 amCHS - BOG

1 stop7h 10mSpirit Airlines

Fri 11/283:17 pmBOG - CHS

1 stop6h 48mSpirit Airlines

Deal found 10/8

$402

Tue 3/105:51 amCHS - BOG

1 stop7h 59mAmerican Airlines

Tue 3/1712:48 amBOG - CHS

1 stop15h 57mAmerican Airlines

Deal found 10/9

$542

Thu 12/45:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Fri 12/126:55 pmCTG - CHS

2 stops21h 50mMultiple Airlines

Deal found 10/7

$422

Mon 1/127:00 pmCHS - LIM

1 stop10h 00mLATAM Airlines

Tue 1/208:25 amLIM - CHS

2 stops15h 14mLATAM Airlines

Deal found 10/8

$570

Mon 1/1210:20 amCHS - LIM

2 stops11h 50mDelta

Tue 1/208:25 amLIM - CHS

2 stops15h 14mDelta

Deal found 10/8

$593

Sun 12/75:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Tue 12/99:18 pmCTG - CHS

2 stops13h 27mMultiple Airlines

Deal found 10/7

$424

Mon 1/126:00 amCHS - LIM

1 stop17h 25mAmerican Airlines

Tue 1/207:00 amLIM - CHS

1 stop16h 55mAmerican Airlines

Deal found 10/8

$588

Mon 1/124:41 pmCHS - LIM

2 stops31h 14mUnited Airlines

Mon 1/191:50 amLIM - CHS

2 stops34h 42mUnited Airlines

Deal found 10/9

$661

Sat 1/1712:15 pmCHS - LIM

1 stop8h 40mLATAM Airlines

Sun 1/258:50 amLIM - CHS

2 stops14h 49mLATAM Airlines

Deal found 10/8

$628

Mon 11/107:00 amCHS - CTG

1 stop6h 15mMultiple Airlines

Sun 11/234:50 amCTG - CHS

2 stops17h 15mMultiple Airlines

Deal found 10/9

$430

Sat 1/175:30 amCHS - LIM

2 stops16h 10mDelta

Sun 1/258:50 amLIM - CHS

2 stops14h 49mDelta

Deal found 10/8

$633

Sat 1/176:00 amCHS - LIM

1 stop17h 25mAmerican Airlines

Sat 1/2412:45 amLIM - CHS

2 stops12h 54mAmerican Airlines

Deal found 10/8

$633

Thu 10/3010:11 amCHS - BOG

2 stops14h 44mMultiple Airlines

Mon 11/31:55 pmBOG - CHS

1 stop18h 42mMultiple Airlines

Deal found 10/7

$440

Wed 10/2912:54 pmCHS - SCL

2 stops16h 31mLATAM Airlines

Tue 11/48:15 amSCL - CHS

2 stops17h 44mLATAM Airlines

Deal found 10/9

$664

Tue 12/95:40 pmCHS - CTG

1 stop19h 28mMultiple Airlines

Thu 12/119:52 pmCTG - CHS

2 stops12h 53mMultiple Airlines

Deal found 10/7

$449

Thu 11/136:28 pmCHS - SCL

1 stop11h 12mLATAM Airlines

Mon 11/178:50 amSCL - CHS

2 stops16h 00mLATAM Airlines

Deal found 10/7

$664

Sat 1/175:40 pmCHS - LIM

1 stop29h 18mSpirit Airlines

Sun 1/2511:59 pmLIM - CHS

1 stop10h 46mSpirit Airlines

Deal found 10/8

$627

Last-minute flights from Charleston to South America
Discover last-minute flight deals from Charleston to South America. Data last updated October 10, 2025 and is based on user searches.

Wed 10/227:55 pmCHS - CTG

3 stops26h 23mMultiple Airlines

Sat 10/259:33 pmCTG - CHS

2 stops10h 33mMultiple Airlines

Deal found 10/8

$501

Thu 10/2310:11 amCHS - CTG

1 stop27h 14mSpirit Airlines

Fri 10/311:32 pmCTG - CHS

2 stops28h 09mSpirit Airlines

Deal found 10/9

$353

Thu 10/3010:11 amCHS - BOG

2 stops14h 44mMultiple Airlines

Mon 11/31:55 pmBOG - CHS

1 stop18h 42mMultiple Airlines

Deal found 10/7

$440

Thu 10/306:15 amCHS - BOG

2 stops17h 20mUnited Airlines

Sun 11/21:30 amBOG - CHS

2 stops19h 38mUnited Airlines

Deal found 10/7

$647

Sun 11/24:24 pmCHS - BOG

1 stop22h 01mDelta

Sat 11/296:15 amBOG - CHS

2 stops16h 35mDelta

Deal found 10/8

$657

Mon 11/37:00 amCHS - BOG

1 stop7h 10mSpirit Airlines

Fri 11/283:17 pmBOG - CHS

1 stop6h 48mSpirit Airlines

Deal found 10/9

$402

Mon 11/36:00 amCHS - BOG

1 stop8h 15mAmerican Airlines

Fri 11/288:00 amBOG - CHS

2 stops14h 24mAmerican Airlines

Deal found 10/8

$598

Mon 11/107:00 amCHS - CTG

1 stop6h 15mSpirit Airlines

Mon 11/242:30 pmCTG - CHS

1 stop7h 35mSpirit Airlines

Deal found 10/9

$256

Mon 11/107:00 amCHS - CTG

3 stops27h 55mMultiple Airlines

Mon 11/242:30 pmCTG - CHS

1 stop7h 35mMultiple Airlines

Deal found 10/9

$401

Mon 11/107:00 amCHS - VCP

1 stop34h 15mMultiple Airlines

Sun 11/2311:20 pmVCP - CHS

1 stop24h 45mMultiple Airlines

Deal found 10/9

$615

Mon 11/106:11 pmCHS - GRU

3 stops33h 29mMultiple Airlines

Wed 11/121:20 amGRU - CHS

2 stops23h 22mMultiple Airlines

Deal found 10/9

$642

Thu 11/1310:40 amCHS - SCL

2 stops15h 50mLATAM Airlines

Mon 11/178:50 amSCL - CHS

2 stops17h 07mLATAM Airlines

Deal found 10/7

$664

One-way flights from Charleston to South America
Search for one-way flight options from Charleston to South America. Find affordable one-way fares based on user searches. Data last updated October 10, 2025.

Sat 12/65:40 pmCHS - MDE

1 stop20h 36mSpirit Airlines

Deal found 10/8

$133

Sat 12/65:40 pmCHS - MDE

2 stops17h 57mMultiple Airlines

Deal found 10/8

$150

Thu 1/15:40 pmCHS - BOG

1 stop7h 00mSpirit Airlines

Deal found 10/6

$219

Thu 1/15:40 pmCHS - BOG

2 stops13h 35mMultiple Airlines

Deal found 10/6

$256

Tue 11/256:50 amCHS - EZE

3 stops19h 20mMultiple Airlines

Deal found 10/8

$355

Thu 10/3010:11 amCHS - MVD

2 stops18h 49mMultiple Airlines

Deal found 10/8

$356

Sun 10/2610:11 amCHS - MVD

2 stops18h 49mMultiple Airlines

Deal found 10/8

$370

Mon 10/277:15 pmCHS - MVD

2 stops33h 45mMultiple Airlines

Deal found 10/9

$371

Fri 10/319:10 pmCHS - MVD

3 stops55h 50mMultiple Airlines

Deal found 10/8

$397

Sat 10/257:55 pmCHS - MVD

3 stops33h 05mMultiple Airlines

Deal found 10/7

$399

Mon 11/2410:40 amCHS - EZE

1 stop20h 20mDelta

Deal found 10/8

$743

Wed 11/2612:53 pmCHS - EZE

3 stops36h 12mLATAM Airlines

Deal found 10/8

$814

Cheap flight deals from Charleston to South America

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$285 (Kiwi.com)
One-way from	$133 (Kiwi.com)

Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 12/5

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Mon 12/8

2:16 pm-10:45 am

1 stop20h 29m

$304

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 12/8

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Thu 12/11

2:16 pm-10:45 am

1 stop20h 29m

$335

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sun 12/7

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Thu 12/11

2:16 pm-10:45 am

1 stop20h 29m

$349

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 12/4

8:53 pm-1:08 pm

2 stops16h 15m

Cartagena Rafael Nunez

Mon 12/8

2:16 pm-10:45 am

1 stop20h 29m

$362

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 12/6

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Thu 12/11

2:16 pm-8:34 am

2 stops18h 18m

$364

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 11/3

7:00 am-2:10 pm

1 stop7h 10m

Bogotá El Dorado

Fri 11/28

3:17 pm-10:05 pm

1 stop6h 48m

$402

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 12/8

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Sat 12/13

7:41 am-10:45 am

2 stops27h 04m

$404

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 12/6

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Sat 12/13

7:41 am-10:45 am

2 stops27h 04m

$404

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 12/8

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Fri 12/12

6:55 pm-4:45 pm

2 stops21h 50m

$409

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 12/4

5:40 pm-1:08 pm

1 stop19h 28m

Cartagena Rafael Nunez

Fri 12/12

6:55 pm-4:45 pm

2 stops21h 50m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/8

Showing 1-10 of 42 results

...

Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to SA?

It’s optimal to fly from Charleston to South America in the afternoon. By choosing this option you can save up to 9% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Charleston to South America?

Travelers seeking maximum savings on their Charleston to South America flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,969 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,969 reviews

Delta

8.0

Very good

7,969 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,861 reviews

Delta

8.0

Very good

7,969 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

11,043 reviews

Delta

8.0

Very good

7,969 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly from for flights from Charleston to South America?
For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.
How long is the flight from Charleston to South America?
Airlines like Spirit Airlines, JetBlue, and Delta fly from Charleston to South America in about 17h 06m. The time it takes to get you to your destination can typically vary by up to 2h 22m. Charleston and South America are separated by a distance of 1983 mi. This flight may include one or multiple stops.
What are the most popular routes from Charleston to South America?
Most travelers choose Charleston - Medellín Jose Maria Cordova Intl, Charleston - Bogotá El Dorado or Charleston - Lima J Chavez Intl when deciding on the best route from Charleston to South America.
Can I find deals for flights from Charleston to South America that include hotel bookings?
Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Charleston to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.
Can I find deals for business class flights from Charleston to South America?
Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Charleston to South America?
Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Charleston to South America

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$458	Average$881	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$472	Average$831	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$491	Average$900	FlexibilityNo cancel fee	On-time81%

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$133+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.

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Find flight deals from Charleston to South America

Cheapest flights from Charleston to South AmericaExplore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2025.

Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2025.

Cheap flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated October 10, 2025.

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Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Charleston to South America that are best for you.

Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

What is the cheapest time of day to fly from CHS to SA?

Find hourly flight availability from Charleston to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 10, 2025.

What is the cheapest day to fly from Charleston to South America?

Use this chart to determine the cheapest time to fly round-trip from Charleston to South America. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South America

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Charleston to South America?

How long is the flight from Charleston to South America?

What are the most popular routes from Charleston to South America?

Can I find deals for flights from Charleston to South America that include hotel bookings?

How can I find direct flights from Charleston to South America?

Can I find deals for business class flights from Charleston to South America?

What is the cheapest month to book a flight from Charleston to South America?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Charleston to South America

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Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2025.