South America

$107+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Feb 7 — Feb 141
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Cheap flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$284
(Kiwi.com)

One-way from

$107
(Trip.com)
Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.
Provider most trusted by Cheapflights users for Charleston-Sao Paulo (SAO) flights.
From Charleston to South America
One-way flight from Charleston to South America

Find flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:35 pmCHS - CTG
1 stop18h 35mSpirit Airlines
Fri 2/272:21 pmCTG - CHS
1 stop27h 19mSpirit Airlines
Deal found 1/5$285
This KAYAK deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:35 pmCHS - GYE
1 stop29h 46mSpirit Airlines
Wed 2/41:26 amGYE - CHS
1 stop16h 13mSpirit Airlines
Deal found 1/7$289
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/148:17 pmCHS - GYE
2 stops18h 13mAmerican Airlines
Tue 2/173:30 pmGYE - CHS
2 stops18h 29mAmerican Airlines
Deal found 1/7$294
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:35 pmCHS - BOG
1 stop19h 35mSpirit Airlines
Sat 2/283:06 pmBOG - CHS
1 stop26h 34mSpirit Airlines
Deal found 1/7$297
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:35 pmCHS - CTG
1 stop18h 35mSpirit Airlines
Sat 2/282:21 pmCTG - CHS
1 stop27h 19mSpirit Airlines
Deal found 1/6$305
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/226:35 pmCHS - CTG
1 stop18h 40mSpirit Airlines
Sun 1/252:21 pmCTG - CHS
1 stop27h 15mSpirit Airlines
Deal found 1/6$321
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:35 pmCHS - GYE
1 stop29h 46mMultiple Airlines
Wed 2/44:40 amGYE - CHS
2 stops12h 59mMultiple Airlines
Deal found 1/7$322
This Avianca Connect deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:35 pmCHS - MDE
1 stop27h 05mMultiple Airlines
Sun 3/11:00 pmMDE - CHS
1 stop28h 40mMultiple Airlines
Deal found 1/8$346
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:35 pmCHS - BOG
1 stop19h 32mSpirit Airlines
Sun 2/223:06 pmBOG - CHS
1 stop26h 34mSpirit Airlines
Deal found 1/6$347
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:35 pmCHS - BOG
2 stops35h 40mMultiple Airlines
Sun 2/223:06 pmBOG - CHS
1 stop26h 34mMultiple Airlines
Deal found 1/5$351
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:35 pmCHS - LIM
1 stop28h 00mSpirit Airlines
Sat 2/2811:30 pmLIM - CHS
1 stop18h 10mSpirit Airlines
Deal found 1/7$355
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:35 pmCHS - GYE
1 stop29h 29mSpirit Airlines
Mon 2/1612:59 amGYE - CHS
2 stops14h 56mSpirit Airlines
Deal found 1/7$363

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 2/1

6:35 pm-12:21 am

1 stop29h 46m

Guayaquil Jose Joaquin de Olmedo

Wed 2/4

1:26 am-5:39 pm

1 stop16h 13m

$289

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 2/14

8:17 pm-2:30 pm

2 stops18h 13m

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

3:30 pm-9:59 am

2 stops18h 29m

$294

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Sat 2/21

6:35 pm-2:10 pm

1 stop19h 35m

Bogotá El Dorado

Sat 2/28

3:06 pm-5:40 pm

1 stop26h 34m

$297

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 2/21

6:35 pm-1:10 pm

1 stop18h 35m

Cartagena Rafael Nunez

Sat 2/28

2:21 pm-5:40 pm

1 stop27h 19m

$305

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 2/20

6:35 pm-1:10 pm

1 stop18h 35m

Cartagena Rafael Nunez

Fri 2/27

2:21 pm-4:05 pm

2 stops25h 44m

$317

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 1/22

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

Sun 1/25

2:21 pm-5:36 pm

1 stop27h 15m

$321

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 2/1

6:35 pm-12:21 am

1 stop29h 46m

Guayaquil Jose Joaquin de Olmedo

Wed 2/4

4:40 am-5:39 pm

2 stops12h 59m

$322

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Sun 2/22

6:35 pm-9:40 pm

1 stop27h 05m

Medellín Jose Maria Cordova Intl

Sun 3/1

1:00 pm-5:40 pm

1 stop28h 40m

$346

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Sat 2/7

6:35 pm-2:07 pm

1 stop19h 32m

Bogotá El Dorado

Sun 2/22

3:06 pm-5:40 pm

1 stop26h 34m

$347

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Sat 2/7

6:35 pm-6:15 am

2 stops35h 40m

Bogotá El Dorado

Sun 2/22

3:06 pm-5:40 pm

1 stop26h 34m

$351

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 8, 2026.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.5

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Crew

8.5

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Crew

8.5

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Crew

8.5

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, American Airlines, and JetBlue fly from Charleston to South America in about 18h 13m. The time it takes to get you to your destination can typically vary by up to 11h 33m. Charleston and South America are separated by a distance of 2420 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are American Airlines ($289), Delta ($356), and LATAM Airlines ($356).

  • What are the most popular routes from Charleston to South America?

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$893FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$784FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$732FlexibilityNo cancel feeOn-time81%

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