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South America

$134+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Jan 16 — Jan 231
Fri 1/16
Fri 1/23
1 adult, Economy
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Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:18 pmCHS - MDE
1 stop27h 10mSpirit Airlines
Wed 12/312:54 pmMDE - CHS
2 stops30h 29mSpirit Airlines
Deal found 12/16$431
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:18 pmCHS - MDE
1 stop27h 10mMultiple Airlines
Wed 12/312:54 pmMDE - CHS
1 stop17h 43mMultiple Airlines
Deal found 12/16$507
This KAYAK deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:18 pmCHS - MDE
2 stops39h 39mSpirit Airlines
Thu 12/252:25 amMDE - CHS
1 stop18h 58mSpirit Airlines
Deal found 12/15$559
This Expedia deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:18 pmCHS - GYE
1 stop25h 35mMultiple Airlines
Wed 1/147:45 amGYE - CHS
2 stops27h 28mMultiple Airlines
Deal found 12/16$597
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:33 pmCHS - CTG
2 stops21h 37mMultiple Airlines
Mon 12/222:15 pmCTG - CHS
1 stop7h 08mMultiple Airlines
Deal found 12/14$613
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:33 pmCHS - BOG
1 stop21h 19mMultiple Airlines
Tue 12/309:48 pmBOG - CHS
2 stops34h 49mMultiple Airlines
Deal found 12/15$648
This Expedia deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mSpirit Airlines
Sun 1/111:26 amGYE - CHS
1 stop16h 10mSpirit Airlines
Deal found 12/16$676
This Expedia deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mMultiple Airlines
Tue 1/137:45 amGYE - CHS
2 stops27h 28mMultiple Airlines
Deal found 12/15$696
This KAYAK deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mSpirit Airlines
Thu 1/112:49 amGYE - CHS
1 stop20h 34mSpirit Airlines
Deal found 12/16$702
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:09 pmCHS - GYE
2 stops26h 26mMultiple Airlines
Sat 12/2712:49 amGYE - CHS
1 stop20h 34mMultiple Airlines
Deal found 12/14$757
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:30 amCHS - GYE
2 stops35h 06mUnited Airlines
Wed 1/142:35 pmGYE - CHS
2 stops49h 42mUnited Airlines
Deal found 12/16$764
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:30 amCHS - GYE
2 stops17h 11mUnited Airlines
Tue 1/1312:20 pmGYE - CHS
2 stops27h 57mUnited Airlines
Deal found 12/15$799

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated December 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$254
(Kiwi.com)

One-way from

$134
(Mytrip)
Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Sao Paulo (SAO) flights.
Search Deals
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 1/30

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

Fri 2/6

2:21 pm-5:36 pm

1 stop27h 15m

$254

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 1/29

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

Thu 2/5

2:21 pm-5:36 pm

1 stop27h 15m

$279

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 2/5

6:35 pm-2:15 pm

1 stop19h 40m

Medellín Jose Maria Cordova Intl

Sun 2/8

3:15 pm-5:36 pm

1 stop26h 21m

$288

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 1/30

6:35 pm-2:07 pm

1 stop19h 32m

Bogotá El Dorado

Fri 2/6

3:06 pm-5:36 pm

1 stop26h 30m

$321

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Fri 1/23

6:35 pm-10:35 pm

1 stop28h 00m

Lima J Chavez Intl

Sun 1/25

11:33 pm-5:36 pm

1 stop18h 03m

$330

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 1/16

6:35 pm-9:40 pm

1 stop27h 05m

Medellín Jose Maria Cordova Intl

Fri 1/23

1:00 pm-5:36 pm

1 stop28h 36m

$339

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Sat 1/31

6:35 pm-10:35 pm

1 stop28h 00m

Lima J Chavez Intl

Sat 2/7

11:33 pm-5:36 pm

1 stop18h 03m

$347

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Thu 1/22

6:35 pm-10:35 pm

1 stop28h 00m

Lima J Chavez Intl

Thu 1/29

11:33 pm-5:36 pm

1 stop18h 03m

$347

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 2/5

6:35 pm-2:15 pm

1 stop19h 40m

Medellín Jose Maria Cordova Intl

Sun 2/8

9:45 am-8:43 am

2 stops22h 58m

$348

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 1/30

6:35 pm-6:52 pm

2 stops24h 17m

Bogotá El Dorado

Fri 2/6

3:06 pm-5:36 pm

1 stop26h 30m

$352

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 55 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to SA?

Find hourly flight availability from Charleston to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 17, 2025.

It’s optimal to fly from Charleston to South America in the morning. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from Charleston to South America?

Use this chart to determine the cheapest time to fly round-trip from Charleston to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Charleston to South America flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated December 17, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,891 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines and Delta fly from Charleston to South America in about 15h 10m. The time it takes to get you to your destination can typically vary by up to 3h 30m. Charleston and South America are separated by a distance of 1983 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Medellín Jose Maria Cordova Intl, Charleston - Lima J Chavez Intl or Charleston - Buenos Aires Ministro Pistarini when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$863FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$435Average$813FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$669FlexibilityNo cancel feeOn-time81%

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