$151+ Cheap flights from Charleston (CHS) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
May 12 — May 191
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to South America with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to South America
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Cheapest flights from Charleston to South AmericaExplore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 12, 2026.
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:53 pm
CHS
- MDE
1 stop23h 07m
Multiple Airlines
Tue 5/191:55 pm
MDE
- CHS
1 stop18h 43m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:53 pm
CHS
- MDE
1 stop23h 07m
Multiple Airlines
Wed 5/201:55 pm
MDE
- CHS
1 stop17h 43m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:56 pm
CHS
- MDE
1 stop15h 04m
Multiple Airlines
Sun 5/101:55 pm
MDE
- CHS
1 stop17h 50m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/223:23 pm
CHS
- MDE
1 stop22h 37m
Multiple Airlines
Fri 5/291:55 pm
MDE
- CHS
1 stop17h 53m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$449
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:38 am
CHS
- MDE
1 stop27h 22m
Multiple Airlines
Sat 5/231:55 pm
MDE
- CHS
1 stop17h 43m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
1 stop23h 17m
Multiple Airlines
Fri 5/82:08 pm
BOG
- CHS
2 stops22h 36m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$518
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
1 stop23h 17m
Multiple Airlines
Sun 5/102:08 pm
BOG
- CHS
2 stops42h 29m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$520
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:47 pm
CHS
- CTG
2 stops17h 48m
American Airlines
Fri 5/291:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/7![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:50 pm
CHS
- CTG
2 stops19h 23m
American Airlines
Mon 6/13:15 pm
CTG
- CHS
1 stop7h 44m
American Airlines
Deal found 4/10![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:09 pm
CHS
- BOG
1 stop16h 11m
American Airlines
Mon 6/296:30 am
BOG
- CHS
1 stop16h 29m
American Airlines
Deal found 4/7![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:00 am
CHS
- CTG
1 stop7h 35m
American Airlines
Mon 6/153:13 pm
CTG
- CHS
2 stops20h 54m
American Airlines
Deal found 4/7![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
CHS
- CTG
1 stop9h 13m
American Airlines
Sun 5/311:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/9![American Airlines logo]()
$570
Best flights from Charleston to South AmericaDiscover carefully curated flight deals from Charleston to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 12, 2026.
Discover carefully curated flight deals from Charleston to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:53 pm
CHS
- MDE
1 stop23h 07m
Multiple Airlines
Tue 5/191:55 pm
MDE
- CHS
1 stop18h 43m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:47 pm
CHS
- CTG
2 stops17h 48m
American Airlines
Fri 5/291:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/7![American Airlines logo]()
$535
This BusinessClass deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:20 am
CHS
- BOG
2 stops13h 50m
LATAM Airlines
Mon 7/2711:00 am
BOG
- CHS
2 stops21h 01m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:15 am
CHS
- BOG
2 stops12h 35m
Delta
Tue 6/1611:00 am
BOG
- CHS
2 stops21h 00m
Delta
Deal found 4/11![Delta logo]()
$604
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:35 am
CHS
- MDE
1 stop15h 35m
United Airlines
Sat 5/239:45 am
MDE
- CHS
1 stop11h 30m
United Airlines
Deal found 4/8![United Airlines logo]()
$623
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
1 stop23h 17m
Multiple Airlines
Fri 5/82:08 pm
BOG
- CHS
2 stops22h 36m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$518
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:47 pm
CHS
- CTG
2 stops19h 26m
American Airlines
Sun 5/311:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/9![American Airlines logo]()
$575
This BusinessClass deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:18 am
CHS
- BOG
2 stops32h 07m
LATAM Airlines
Wed 7/225:15 pm
BOG
- CHS
2 stops29h 04m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$583
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:10 am
CHS
- BOG
1 stop15h 05m
Delta
Mon 6/2911:00 am
BOG
- CHS
2 stops22h 18m
Delta
Deal found 4/7![Delta logo]()
$620
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:15 am
CHS
- MDE
2 stops35h 55m
United Airlines
Sat 5/239:45 am
MDE
- CHS
2 stops23h 23m
United Airlines
Deal found 4/12![United Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:50 pm
CHS
- CTG
2 stops17h 45m
American Airlines
Tue 6/163:13 pm
CTG
- CHS
1 stop7h 46m
American Airlines
Deal found 4/7![American Airlines logo]()
$575
This Avianca deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:39 am
CHS
- BOG
2 stops14h 01m
Multiple Airlines
Tue 6/27:00 pm
BOG
- CHS
2 stops12h 39m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/811:18 am
CHS
- BOG
1 stop11h 42m
United Airlines
Mon 6/298:30 am
BOG
- CHS
1 stop12h 45m
United Airlines
Deal found 4/10![United Airlines logo]()
$632
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:34 am
CHS
- MDE
2 stops15h 26m
American Airlines
Tue 11/37:00 am
MDE
- CHS
2 stops12h 12m
American Airlines
Deal found 4/9![American Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:30 am
CHS
- LIM
2 stops16h 05m
Delta
Tue 9/2212:05 pm
LIM
- CHS
1 stop20h 38m
Delta
Deal found 4/10![Delta logo]()
$659
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:13 pm
CHS
- CTG
2 stops17h 56m
American Airlines
Sun 5/173:10 pm
CTG
- CHS
2 stops19h 34m
American Airlines
Deal found 4/8![American Airlines logo]()
$591
This oojo deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:24 am
CHS
- UIO
1 stop20h 11m
Multiple Airlines
Sun 5/249:20 am
UIO
- CHS
2 stops22h 19m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$651
This FlightHub deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:45 am
CHS
- LIM
2 stops13h 35m
LATAM Airlines
Sat 9/58:55 am
LIM
- CHS
2 stops14h 02m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
CHS
- BOG
1 stop8h 05m
American Airlines
Tue 6/26:30 am
BOG
- CHS
1 stop16h 29m
American Airlines
Deal found 4/11![American Airlines logo]()
$595
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:55 pm
CHS
- LIM
1 stop13h 05m
Delta
Tue 8/48:55 am
LIM
- CHS
2 stops14h 31m
Delta
Deal found 4/6![Delta logo]()
$743
This FlightHub deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:57 pm
CHS
- LIM
1 stop12h 03m
LATAM Airlines
Wed 5/612:05 pm
LIM
- CHS
1 stop10h 45m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$762
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:11 am
CHS
- MDE
2 stops16h 04m
American Airlines
Sat 5/236:00 am
MDE
- CHS
2 stops16h 54m
American Airlines
Deal found 4/7![American Airlines logo]()
$608
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:24 pm
CHS
- LIM
1 stop11h 36m
Delta
Thu 7/2312:05 pm
LIM
- CHS
1 stop19h 56m
Delta
Deal found 4/8![Delta logo]()
$765
This FlightHub deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:20 am
CHS
- LIM
1 stop15h 35m
LATAM Airlines
Wed 6/248:55 am
LIM
- CHS
2 stops14h 41m
LATAM Airlines
Deal found 4/11![LATAM Airlines logo]()
$767
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:50 am
CHS
- MDE
1 stop8h 00m
American Airlines
Sun 9/66:00 am
MDE
- CHS
1 stop17h 16m
American Airlines
Deal found 4/7![American Airlines logo]()
$638
This Expedia deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:25 am
CHS
- LIM
1 stop15h 30m
LATAM Airlines
Thu 5/1412:05 pm
LIM
- CHS
1 stop23h 05m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$776
This Mytrip deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:39 pm
CHS
- SCL
3 stops23h 36m
Multiple Airlines
Tue 6/212:30 am
SCL
- CHS
3 stops37h 14m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$925
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
CHS
- UIO
1 stop17h 32m
American Airlines
Sun 5/246:00 am
UIO
- CHS
1 stop16h 59m
American Airlines
Deal found 4/7![American Airlines logo]()
$671
This Mytrip deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:39 pm
CHS
- GRU
3 stops32h 51m
Multiple Airlines
Tue 5/193:50 am
GRU
- CHS
3 stops34h 54m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$926
This LATAM Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:25 am
CHS
- UIO
1 stop12h 34m
LATAM Airlines
Sun 4/2612:59 am
UIO
- CHS
1 stop9h 21m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$854
Last-minute flights from Charleston to South AmericaDiscover last-minute flight deals from Charleston to South America. Data last updated April 12, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to South America. Data last updated April 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:56 pm
CHS
- MDE
1 stop15h 04m
Multiple Airlines
Sun 5/101:55 pm
MDE
- CHS
1 stop17h 50m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
1 stop23h 17m
Multiple Airlines
Fri 5/82:08 pm
BOG
- CHS
2 stops22h 36m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$518
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
1 stop23h 17m
Multiple Airlines
Sun 5/102:08 pm
BOG
- CHS
2 stops42h 29m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$520
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:53 pm
CHS
- MDE
1 stop23h 07m
Multiple Airlines
Tue 5/191:55 pm
MDE
- CHS
1 stop18h 43m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:53 pm
CHS
- MDE
1 stop23h 07m
Multiple Airlines
Wed 5/201:55 pm
MDE
- CHS
1 stop17h 43m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:38 am
CHS
- MDE
1 stop27h 22m
Multiple Airlines
Sat 5/231:55 pm
MDE
- CHS
1 stop17h 43m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$464
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:13 pm
CHS
- CTG
2 stops17h 56m
American Airlines
Sun 5/173:10 pm
CTG
- CHS
2 stops19h 34m
American Airlines
Deal found 4/8![American Airlines logo]()
$591
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/223:23 pm
CHS
- MDE
1 stop22h 37m
Multiple Airlines
Fri 5/291:55 pm
MDE
- CHS
1 stop17h 53m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$449
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:47 pm
CHS
- CTG
2 stops17h 48m
American Airlines
Fri 5/291:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/7![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
CHS
- CTG
1 stop9h 13m
American Airlines
Sun 5/311:35 pm
CTG
- CHS
1 stop9h 24m
American Airlines
Deal found 4/9![American Airlines logo]()
$570
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:50 pm
CHS
- CTG
2 stops19h 23m
American Airlines
Mon 6/13:15 pm
CTG
- CHS
1 stop7h 44m
American Airlines
Deal found 4/10![American Airlines logo]()
$555
This Avianca deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:39 am
CHS
- BOG
2 stops14h 01m
Multiple Airlines
Tue 6/27:00 pm
BOG
- CHS
2 stops12h 39m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$584
One-way flights from Charleston to South AmericaSearch for one-way flight options from Charleston to South America. Find affordable one-way fares based on user searches. Data last updated April 12, 2026.
Search for one-way flight options from Charleston to South America. Find affordable one-way fares based on user searches. Data last updated April 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:01 pm
CHS
- MDE
1 stop22h 59m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:39 pm
CHS
- MDE
3 stops33h 47m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:38 am
CHS
- MDE
3 stops37h 49m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:13 pm
CHS
- MDE
2 stops16h 07m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$190
This oojo deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:14 pm
CHS
- UIO
2 stops20h 56m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/133:23 pm
CHS
- MDE
2 stops32h 02m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:18 pm
CHS
- MDE
3 stops43h 42m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:28 pm
CHS
- BOG
2 stops28h 38m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:28 pm
CHS
- MDE
3 stops40h 32m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:39 pm
CHS
- UIO
3 stops33h 21m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$220
This oojo deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:14 pm
CHS
- UIO
2 stops17h 51m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:09 pm
CHS
- BOG
1 stop17h 56m
American Airlines
Deal found 4/7![American Airlines logo]()
$348
Find flight deals from Charleston to South America
Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated April 12, 2026.
Round-trip from | $367 (Kiwi.com) |
|---|---|
One-way from | $151 (Kiwi.com) |
Popular in | July |
Cheapest in | September |
Average price | $523 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonMedellín
CHS - MDE
CHSMDE
Charleston
Thu 5/7
2:53 pm-1:00 pm
1 stop23h 07m
Medellín Jose Maria Cordova Intl
Tue 5/19
1:55 pm-9:38 am
1 stop18h 43m
$367
CharlestonBogotá
CHS - BOG
CHSBOG
Charleston
Mon 5/4
8:28 pm-6:45 pm
1 stop23h 17m
Bogotá El Dorado
Fri 5/8
2:08 pm-1:44 pm
2 stops22h 36m
$518
CharlestonCartagena
CHS - CTG
CHSCTG
Charleston
Fri 5/22
7:47 pm-12:35 pm
2 stops17h 48m
Cartagena Rafael Nunez
Fri 5/29
1:35 pm-11:59 pm
1 stop9h 24m
$535
CharlestonCartagena
CHS - CTG
CHSCTG
Charleston
Sun 5/24
7:47 pm-2:13 pm
2 stops19h 26m
Cartagena Rafael Nunez
Sun 5/31
1:35 pm-11:59 pm
1 stop9h 24m
$575
CharlestonCartagena
CHS - CTG
CHSCTG
Charleston
Sun 6/14
7:50 pm-12:35 pm
2 stops17h 45m
Cartagena Rafael Nunez
Tue 6/16
3:13 pm-11:59 pm
1 stop7h 46m
$575
CharlestonBogotá
CHS - BOG
CHSBOG
Charleston
Mon 7/20
7:20 am-8:10 pm
2 stops13h 50m
Bogotá El Dorado
Mon 7/27
11:00 am-9:01 am
2 stops21h 01m
$582
CharlestonMedellín
CHS - MDE
CHSMDE
Charleston
Sat 10/3
5:34 am-8:00 pm
2 stops15h 26m
Medellín Jose Maria Cordova Intl
Tue 11/3
7:00 am-7:12 pm
2 stops12h 12m
$582
CharlestonBogotá
CHS - BOG
CHSBOG
Charleston
Wed 7/15
11:18 am-6:25 pm
2 stops32h 07m
Bogotá El Dorado
Wed 7/22
5:15 pm-11:19 pm
2 stops29h 04m
$583
CharlestonBogotá
CHS - BOG
CHSBOG
Charleston
Tue 5/26
10:39 am-11:40 pm
2 stops14h 01m
Bogotá El Dorado
Tue 6/2
7:00 pm-8:39 am
2 stops12h 39m
$584
CharlestonCartagena
CHS - CTG
CHSCTG
Charleston
Wed 5/13
7:13 pm-12:09 pm
2 stops17h 56m
Cartagena Rafael Nunez
Sun 5/17
3:10 pm-11:44 am
2 stops19h 34m
$591
Showing 1-10 of 55 resultsSorted by cheapest first
Best time to book a flight from Charleston to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
CHS-MDE
CHS-CTG
CHS-BOG
CHS-LIM
CHS-UIO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to South America
CHS-0SA
CHS-MDE
CHS-CTG
CHS-BOG
CHS-LIM
What is the cheapest month to book a flight from Charleston to South America?
Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $561). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 12, 2026.
See what other customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Charleston to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Charleston to South America by cabin class
Find flights from Charleston to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and South America flights
Browse other Charleston and South America flight options. Last updated on April 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
Consider these flights traveling to countries located in South America.
Charleston to South America flights
Consider these flights traveling from Charleston to South America.
Top 3 airlines flying from Charleston to South America
Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$301 | Average$677 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$465 | Average$715 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$542 | Average$732 | FlexibilityNo cancel fee | On-time81% |