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South America

$115+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:49 pmCHS - MDE
1 stop27h 20mSpirit Airlines
Wed 12/173:10 pmMDE - CHS
1 stop30h 13mSpirit Airlines
Deal found 11/5$266
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:50 amCHS - MDE
1 stop18h 06mSpirit Airlines
Thu 12/43:10 pmMDE - CHS
1 stop29h 44mSpirit Airlines
Deal found 11/5$293
This Avianca Connect deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:50 amCHS - MDE
1 stop14h 50mMultiple Airlines
Sun 12/71:00 pmMDE - CHS
1 stop7h 54mMultiple Airlines
Deal found 11/5$299
This KAYAK deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:50 amCHS - CTG
1 stop6h 35mSpirit Airlines
Mon 12/82:15 pmCTG - CHS
1 stop6h 39mSpirit Airlines
Deal found 11/6$301
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:49 pmCHS - MDE
2 stops16h 08mMultiple Airlines
Mon 12/152:54 pmMDE - CHS
1 stop17h 43mMultiple Airlines
Deal found 11/5$306
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:49 pmCHS - MDE
2 stops16h 08mMultiple Airlines
Wed 12/172:54 pmMDE - CHS
1 stop17h 43mMultiple Airlines
Deal found 11/5$317
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:50 amCHS - MDE
1 stop18h 06mSpirit Airlines
Wed 12/102:05 amMDE - CHS
1 stop18h 49mSpirit Airlines
Deal found 11/5$319
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:50 amCHS - MDE
1 stop18h 06mSpirit Airlines
Sun 12/72:05 amMDE - CHS
1 stop18h 49mSpirit Airlines
Deal found 11/5$320
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:50 amCHS - MDE
1 stop14h 50mMultiple Airlines
Sun 12/71:00 pmMDE - CHS
1 stop7h 54mMultiple Airlines
Deal found 11/5$324
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:33 pmCHS - MDE
1 stop19h 22mMultiple Airlines
Wed 12/102:54 pmMDE - CHS
1 stop17h 43mMultiple Airlines
Deal found 11/5$340
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:33 pmCHS - MDE
1 stop19h 22mMultiple Airlines
Sun 12/142:05 amMDE - CHS
1 stop18h 49mMultiple Airlines
Deal found 11/5$341
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:50 amCHS - MDE
1 stop14h 50mMultiple Airlines
Fri 12/51:00 pmMDE - CHS
1 stop7h 54mMultiple Airlines
Deal found 11/5$343

Cheap flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated November 6, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$266
(Kiwi.com)

One-way from

$115
(Mytrip)
Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Sao Paulo (SAO) flights.
Search Deals
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 12/1

6:50 am-1:25 pm

1 stop6h 35m

Cartagena Rafael Nunez

Mon 12/8

2:15 pm-8:54 pm

1 stop6h 39m

$301

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 11/20

6:13 pm-2:10 pm

2 stops19h 57m

Bogotá El Dorado

Thu 11/27

3:17 pm-10:05 pm

1 stop6h 48m

$482

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Fri 12/5

9:49 pm-10:35 pm

1 stop24h 46m

Lima J Chavez Intl

Thu 12/11

1:50 am-8:54 pm

2 stops19h 04m

$488

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 11/20

6:13 pm-2:10 pm

2 stops19h 57m

Bogotá El Dorado

Thu 11/27

5:00 am-10:05 pm

2 stops17h 05m

$497

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 1/16

3:21 pm-4:00 pm

1 stop24h 39m

Medellín Jose Maria Cordova Intl

Thu 1/22

1:51 am-5:36 pm

1 stop15h 45m

$506

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 1/22

6:10 am-3:30 pm

2 stops9h 20m

Cartagena Rafael Nunez

Mon 1/26

2:30 pm-11:39 am

2 stops21h 09m

$510

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 12/4

9:25 am-9:30 pm

1 stop12h 05m

Cartagena Rafael Nunez

Wed 12/10

2:30 pm-12:46 am

1 stop10h 16m

$513

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 12/5

11:55 am-1:10 pm

2 stops25h 15m

Cartagena Rafael Nunez

Mon 12/8

2:15 pm-8:54 pm

1 stop6h 39m

$514

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 12/4

9:49 pm-1:10 pm

1 stop15h 21m

Cartagena Rafael Nunez

Sun 12/7

2:15 pm-8:54 pm

1 stop6h 39m

$519

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 12/4

6:00 am-9:30 pm

1 stop15h 30m

Cartagena Rafael Nunez

Sun 12/7

4:30 pm-8:45 am

1 stop16h 15m

$523

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to SA?

Find hourly flight availability from Charleston to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Charleston to South America in the morning. By choosing this option you can save up to 30% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from Charleston to South America?

Use this chart to determine the cheapest time to fly round-trip from Charleston to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Charleston to South America flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 6, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,874 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,041 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, American Airlines, and Copa Airlines fly from Charleston to South America in about 6h 35m. The time it takes to get you to your destination can typically vary by up to 14h 43m. Charleston and South America are separated by a distance of 1577 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Medellín Jose Maria Cordova Intl, Charleston - Sao Paulo Guarulhos Intl or Charleston - Lima J Chavez Intl when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$882FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$805FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$918FlexibilityNo cancel feeOn-time81%

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