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South America

$97+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
ene. 27 — feb. 31
mar. 1/27
mar. 2/3
1 adult, Economy
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Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2910:18 pmCHS - MDE
1 stop23h 22mMultiple Airlines
mié. 12/312:25 amMDE - CHS
1 stop18h 58mMultiple Airlines
Deal found 12/26$515
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2810:18 pmCHS - MDE
1 stop23h 22mMultiple Airlines
mié. 12/312:25 amMDE - CHS
1 stop18h 58mMultiple Airlines
Deal found 12/26$539
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/302:59 pmCHS - MDE
1 stop19h 56mMultiple Airlines
mié. 12/312:25 amMDE - CHS
1 stop18h 58mMultiple Airlines
Deal found 12/26$598
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/319:09 pmCHS - MDE
2 stops28h 19mMultiple Airlines
mié. 1/72:54 pmMDE - CHS
1 stop17h 44mMultiple Airlines
Deal found 12/26$635
This Expedia deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2610:18 pmCHS - CTG
1 stop14h 52mMultiple Airlines
mar. 12/303:22 pmCTG - CHS
1 stop8h 36mMultiple Airlines
Deal found 12/25$650
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2910:18 pmCHS - MDE
1 stop23h 22mMultiple Airlines
mié. 1/78:30 pmMDE - CHS
2 stops45h 06mMultiple Airlines
Deal found 12/26$657
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/302:59 pmCHS - MDE
1 stop19h 56mMultiple Airlines
mié. 1/72:54 pmMDE - CHS
1 stop17h 44mMultiple Airlines
Deal found 12/26$693
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2810:18 pmCHS - MDE
1 stop23h 22mMultiple Airlines
mié. 1/72:54 pmMDE - CHS
1 stop17h 44mMultiple Airlines
Deal found 12/26$708
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/278:07 pmCHS - GYE
1 stop27h 43mAmerican Airlines
vie. 1/26:08 amGYE - CHS
1 stop26h 39mAmerican Airlines
Deal found 12/26$715
This Kiwi.com deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2610:18 pmCHS - CTG
2 stops22h 27mMultiple Airlines
jue. 1/82:21 pmCTG - CHS
1 stop27h 15mMultiple Airlines
Deal found 12/25$784
This Expedia deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:03 pmCHS - CTG
1 stop18h 10mMultiple Airlines
mar. 12/303:22 pmCTG - CHS
1 stop8h 36mMultiple Airlines
Deal found 12/25$808
This Kiwi.com deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2610:18 pmCHS - CTG
1 stop14h 52mSpirit Airlines
jue. 1/82:21 pmCTG - CHS
1 stop27h 15mSpirit Airlines
Deal found 12/25$823

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated diciembre 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$288
(KAYAK)

One-way from

$97
(Trip.com)
Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Sao Paulo (SAO) flights.
Search Deals
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 28, 2025.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

lun. 1/19

6:35 pm-12:21 am

1 stop29h 46m

Guayaquil Jose Joaquin de Olmedo

dom. 1/25

1:26 am-5:36 pm

1 stop16h 10m

$288

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

lun. 2/9

6:10 am-11:22 pm

2 stops17h 12m

Guayaquil Jose Joaquin de Olmedo

lun. 2/16

7:11 am-10:16 am

1 stop27h 05m

$299

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

lun. 1/19

6:35 pm-12:21 am

1 stop29h 46m

Guayaquil Jose Joaquin de Olmedo

dom. 1/25

4:40 am-5:36 pm

2 stops12h 56m

$313

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

lun. 2/23

6:35 pm-9:40 pm

1 stop27h 05m

Medellín Jose Maria Cordova Intl

dom. 3/1

1:00 pm-5:40 pm

1 stop28h 40m

$317

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

dom. 2/1

6:35 pm-9:40 pm

1 stop27h 05m

Medellín Jose Maria Cordova Intl

jue. 3/19

1:00 pm-11:26 pm

1 stop9h 26m

$336

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

sáb. 1/24

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

sáb. 1/31

2:21 pm-5:36 pm

1 stop27h 15m

$338

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

dom. 1/25

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

dom. 2/1

2:21 pm-5:36 pm

1 stop27h 15m

$357

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

jue. 1/29

6:35 pm-9:40 pm

1 stop27h 05m

Medellín Jose Maria Cordova Intl

lun. 2/2

6:55 am-5:36 pm

2 stops10h 41m

$363

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

sáb. 1/24

6:35 pm-1:15 pm

1 stop18h 40m

Cartagena Rafael Nunez

sáb. 1/31

10:07 pm-5:36 pm

2 stops43h 29m

$370

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

sáb. 1/24

6:35 pm-11:13 pm

2 stops28h 38m

Bogotá El Dorado

sáb. 1/31

1:45 pm-8:38 am

1 stop18h 53m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated diciembre 28, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,016 reviews

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,016 reviews
Delta
7.9
Good
8,016 reviews

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,895 reviews
Delta
7.9
Good
8,016 reviews

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,071 reviews
Delta
7.9
Good
8,016 reviews

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, American Airlines, and LATAM Airlines fly from Charleston to South America in about 17h 12m. The time it takes to get you to your destination can typically vary by up to 12h 34m. Charleston and South America are separated by a distance of 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Medellín Jose Maria Cordova Intl, Charleston - Lima J Chavez Intl or Charleston - Buenos Aires Ministro Pistarini when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$893FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$435Average$782FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$669FlexibilityNo cancel feeOn-time81%

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