$497+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 3 — Nov 101
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 4, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 4, 2026.
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:00 am -
1 stop23h 15m
Sun 2/2811:45 pm -
1 stop21h 01m
Deal found 10/4![American Airlines logo]()
$1,076
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:13 am -
2 stops17h 27m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/30![Delta logo]()
$1,085
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
This LATAM Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:59 pm -
2 stops18h 01m
Sun 2/287:00 pm -
2 stops16h 42m
Deal found 10/4![LATAM Airlines logo]()
$1,119
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:52 pm -
3 stops26h 23m
Thu 10/88:20 am -
2 stops16h 39m
Deal found 9/30![LATAM Airlines logo]()
$1,120
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 pm -
2 stops59h 50m
Sat 11/2110:45 pm -
2 stops38h 36m
Deal found 9/30![United Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:42 am -
1 stop19h 03m
Sat 11/2110:30 pm -
1 stop14h 22m
Deal found 9/30![American Airlines logo]()
$1,135
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:55 pm -
1 stop15h 45m
Thu 12/2411:00 pm -
1 stop16h 11m
Deal found 10/2![Delta logo]()
$1,136
This LATAM Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:55 pm -
1 stop15h 45m
Sun 12/207:00 pm -
2 stops18h 45m
Deal found 10/2![LATAM Airlines logo]()
$1,139
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1311:24 am -
1 stop17h 16m
Sun 2/2811:50 pm -
1 stop18h 25m
Deal found 10/4![Delta logo]()
$1,146
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 pm -
1 stop12h 30m
Thu 10/89:30 pm -
1 stop27h 29m
Deal found 9/30![American Airlines logo]()
$1,147
This SmartFares deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:18 pm -
1 stop17h 22m
Sat 1/168:15 am -
3 stops28h 43m
Deal found 9/30![LATAM Airlines logo]()
$1,160
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2911:16 am -
2 stops19h 44m
Mon 2/111:45 pm -
1 stop18h 12m
Deal found 9/30![American Airlines logo]()
$1,080
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 pm -
2 stops59h 50m
Sat 11/2110:45 pm -
2 stops38h 36m
Deal found 9/30![United Airlines logo]()
$1,130
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:45 am -
3 stops25h 56m
Sun 3/74:35 pm -
2 stops28h 14m
Deal found 9/30![LATAM Airlines logo]()
$1,135
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1311:24 am -
1 stop17h 16m
Sun 2/2811:50 pm -
1 stop18h 25m
Deal found 10/4![Delta logo]()
$1,146
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:00 am -
1 stop23h 50m
Sun 3/710:45 pm -
1 stop18h 33m
Deal found 9/29![United Airlines logo]()
$1,150
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/152:04 pm -
1 stop14h 36m
Fri 12/2511:00 pm -
1 stop18h 16m
Deal found 10/2![Delta logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:18 pm -
3 stops22h 42m
Sun 11/227:40 am -
2 stops17h 14m
Deal found 10/1![LATAM Airlines logo]()
$1,246
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:42 am -
1 stop19h 03m
Sat 11/2110:30 pm -
1 stop14h 22m
Deal found 9/30![American Airlines logo]()
$1,135
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:37 pm -
2 stops37h 13m
Fri 11/1310:45 pm -
2 stops24h 13m
Deal found 9/30![United Airlines logo]()
$1,170
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:00 am -
2 stops19h 35m
Thu 12/3111:50 pm -
2 stops21h 06m
Deal found 10/4![Delta logo]()
$1,484
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/296:00 am -
2 stops31h 35m
Thu 4/14:50 am -
2 stops19h 45m
Deal found 9/30![LATAM Airlines logo]()
$1,571
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated October 4, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated October 4, 2026 and is based on user searches.
This Orbitz deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:25 pm -
2 stops27h 55m
Tue 10/67:40 am -
2 stops27h 39m
Deal found 9/30![Multiple Airlines logo]()
$1,406
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:52 pm -
2 stops18h 13m
Tue 10/68:40 pm -
1 stop14h 30m
Deal found 9/30![LATAM Airlines logo]()
$1,487
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:37 pm -
2 stops37h 13m
Fri 11/1310:45 pm -
2 stops24h 13m
Deal found 9/30![United Airlines logo]()
$1,170
This Expedia deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 pm -
2 stops23h 00m
Fri 11/138:35 am -
3 stops27h 38m
Deal found 9/30![LATAM Airlines logo]()
$1,231
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 pm -
2 stops59h 50m
Sat 11/2110:45 pm -
2 stops38h 36m
Deal found 9/30![United Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:42 am -
1 stop19h 03m
Sat 11/2110:30 pm -
1 stop14h 22m
Deal found 9/30![American Airlines logo]()
$1,135
This oojo deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:49 am -
2 stops18h 11m
Sat 11/218:35 am -
3 stops27h 38m
Deal found 9/30![LATAM Airlines logo]()
$1,393
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
This Cheapflightsfares deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:18 pm -
1 stop15h 22m
Sun 11/224:35 pm -
2 stops27h 30m
Deal found 10/1![LATAM Airlines logo]()
$1,210
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:16 pm -
1 stop11h 09m
Sun 11/2910:30 pm -
1 stop23h 16m
Deal found 9/30![American Airlines logo]()
$1,246
This oojo deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:11 am -
2 stops20h 49m
Sun 11/298:35 am -
3 stops27h 12m
Deal found 9/30![LATAM Airlines logo]()
$1,593
This Orbitz deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/288:11 am -
1 stop21h 29m
Sun 11/294:35 pm -
2 stops33h 18m
Deal found 9/30![LATAM Airlines logo]()
$1,565
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/202:13 pm -
3 stops37h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/153:00 pm -
2 stops32h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$527
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/213:27 pm -
3 stops35h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$580
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/189:38 pm -
3 stops44h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$698
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:42 pm -
3 stops41h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$713
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:30 am -
2 stops19h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![United Airlines logo]()
$747
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/267:37 pm -
1 stop11h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/3![American Airlines logo]()
$750
This Cheapflightsfares deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![LATAM Airlines logo]()
$756
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:34 pm -
1 stop12h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Delta logo]()
$759
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/207:59 pm -
1 stop33h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Delta logo]()
$773
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:40 am -
3 stops28h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$787
This BusinessClass deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/269:43 am -
2 stops21h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/3![GOL logo]()
$808
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 4, 2026.
Round-trip from | $1,075 (American Airlines) |
|---|---|
One-way from | $497 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 4, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 12/15
3:00 pm-6:38 am
3 stops37h 38m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$548
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 12/18
9:38 pm-8:11 pm
3 stops44h 33m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$698
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sun 12/20
2:13 pm-12:08 am
2 stops31h 55m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$710
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
11:30 am-8:50 am
2 stops19h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$747
Quickest round-trip
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Sat 12/26
7:37 pm-9:20 am
1 stop11h 43m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$750
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$756
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 12/15
2:04 pm-7:40 am
1 stop15h 36m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$759
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Wed 12/16
5:34 pm-7:40 am
1 stop12h 06m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$759
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Sat 12/26
9:43 am-9:20 am
2 stops21h 37m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$808
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Sat 12/26
3:43 pm-6:40 am
3 stops36h 57m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$922
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Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CHS-SCL
MYR-SCL
GSP-SCL
Estimated round-trip price
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Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CHS-SCL
MYR-SCL
GSP-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on October 4, 2026.
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 4, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$1,134 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$763 | Average$974 | FlexibilityNo cancel fee | On-timeN/A |