$342+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Apr 7 — Apr 141
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Wed 5/610:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$579
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/78:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$582
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/711:00 pm
SCL
- CLT
1 stop14h 43m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$585
This Mytrip deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops31h 00m
Multiple Airlines
Thu 4/238:20 pm
SCL
- CLT
3 stops25h 41m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$587
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:28 pm
CLT
- SCL
2 stops30h 37m
Multiple Airlines
Sun 5/1710:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$594
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/78:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$598
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:42 am
CLT
- SCL
2 stops50h 58m
Multiple Airlines
Sat 5/308:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$615
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Sun 5/310:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$618
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Sun 5/310:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$620
This Mytrip deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- SCL
2 stops31h 00m
Multiple Airlines
Mon 4/2711:35 am
SCL
- CLT
2 stops21h 35m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$623
This KAYAK deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:55 pm
CHS
- SCL
2 stops19h 10m
LATAM Airlines
Wed 9/235:40 am
SCL
- CHS
2 stops19h 17m
LATAM Airlines
Deal found 3/6![LATAM Airlines logo]()
$775
This FlightHub deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:55 pm
GSP
- SCL
2 stops19h 30m
LATAM Airlines
Mon 12/74:10 am
SCL
- GSP
2 stops21h 27m
LATAM Airlines
Deal found 3/6![LATAM Airlines logo]()
$811
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This Mytrip deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- SCL
2 stops31h 00m
Multiple Airlines
Mon 4/2711:35 am
SCL
- CLT
2 stops21h 35m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$623
This Copa Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:44 pm
CLT
- SCL
2 stops27h 42m
Copa Airlines
Tue 8/112:27 am
SCL
- CLT
2 stops31h 15m
Copa Airlines
Deal found 3/2![Copa Airlines logo]()
$778
This KAYAK deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:59 pm
CLT
- SCL
2 stops23h 46m
LATAM Airlines
Wed 8/126:00 pm
SCL
- CLT
3 stops24h 17m
LATAM Airlines
Deal found 3/2![LATAM Airlines logo]()
$830
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:30 am
CLT
- SCL
1 stop25h 45m
Delta
Wed 8/128:40 pm
SCL
- CLT
1 stop21h 37m
Delta
Deal found 3/2![Delta logo]()
$832
This Air Canada deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:05 pm
CLT
- SCL
1 stop17h 10m
Air Canada
Wed 3/257:55 pm
SCL
- CLT
1 stop26h 02m
Air Canada
Deal found 3/2![Air Canada logo]()
$843
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:14 am
CHS
- SCL
1 stop19h 51m
American Airlines
Tue 6/28:35 pm
SCL
- CHS
1 stop22h 15m
American Airlines
Deal found 3/3![American Airlines logo]()
$854
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:57 am
MYR
- SCL
2 stops35h 29m
United Airlines
Thu 4/2312:46 am
SCL
- MYR
2 stops34h 02m
United Airlines
Deal found 3/3![United Airlines logo]()
$1,113
This Mytrip deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Sat 4/253:20 pm
SCL
- CLT
2 stops29h 29m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$698
This KAYAK deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:40 am
CLT
- SCL
2 stops22h 20m
LATAM Airlines
Wed 8/126:00 pm
SCL
- CLT
3 stops24h 17m
LATAM Airlines
Deal found 3/2![LATAM Airlines logo]()
$830
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:55 am
CLT
- SCL
2 stops20h 05m
Delta
Wed 5/67:55 pm
SCL
- CLT
2 stops15h 11m
Delta
Deal found 3/5![Delta logo]()
$870
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:52 am
GSP
- SCL
2 stops20h 13m
American Airlines
Fri 4/248:35 pm
SCL
- GSP
1 stop21h 40m
American Airlines
Deal found 3/3![American Airlines logo]()
$905
This KAYAK deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:20 am
CHS
- SCL
2 stops22h 40m
LATAM Airlines
Tue 5/264:10 am
SCL
- CHS
2 stops19h 49m
LATAM Airlines
Deal found 3/3![LATAM Airlines logo]()
$833
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:21 pm
CLT
- SCL
1 stop15h 04m
Delta
Mon 5/410:55 pm
SCL
- CLT
1 stop15h 45m
Delta
Deal found 3/5![Delta logo]()
$870
This Expedia deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:35 pm
CHS
- SCL
1 stop14h 40m
Multiple Airlines
Sat 4/259:10 pm
SCL
- CHS
2 stops43h 22m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$893
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1512:37 pm
GSP
- SCL
2 stops18h 28m
American Airlines
Fri 7/178:30 pm
SCL
- GSP
2 stops22h 29m
American Airlines
Deal found 3/5![American Airlines logo]()
$920
This Ovago deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:41 pm
GSP
- SCL
1 stop13h 34m
LATAM Airlines
Wed 4/158:40 pm
SCL
- GSP
1 stop15h 41m
LATAM Airlines
Deal found 3/3![LATAM Airlines logo]()
$868
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:13 am
GSP
- SCL
2 stops19h 47m
Delta
Wed 4/158:40 pm
SCL
- GSP
1 stop12h 29m
Delta
Deal found 3/4![Delta logo]()
$870
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:26 pm
GSP
- SCL
1 stop11h 24m
American Airlines
Wed 4/158:35 pm
SCL
- GSP
2 stops23h 26m
American Airlines
Deal found 3/5![American Airlines logo]()
$951
This LATAM Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:06 am
GSP
- SCL
2 stops17h 44m
LATAM Airlines
Thu 4/304:10 am
SCL
- GSP
2 stops19h 46m
LATAM Airlines
Deal found 3/7![LATAM Airlines logo]()
$870
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:00 am
CHS
- SCL
1 stop24h 25m
Delta
Mon 4/137:55 pm
SCL
- CHS
2 stops17h 40m
Delta
Deal found 3/4![Delta logo]()
$873
This LATAM Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:03 pm
GSP
- SCL
3 stops22h 22m
LATAM Airlines
Mon 4/2711:00 pm
SCL
- GSP
2 stops23h 13m
LATAM Airlines
Deal found 3/6![LATAM Airlines logo]()
$875
This LATAM Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:17 pm
CHS
- SCL
1 stop17h 58m
LATAM Airlines
Tue 6/27:45 am
SCL
- CHS
2 stops16h 14m
LATAM Airlines
Deal found 3/7![LATAM Airlines logo]()
$904
This LATAM Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:23 am
MYR
- SCL
2 stops26h 42m
LATAM Airlines
Wed 3/255:15 am
SCL
- MYR
2 stops19h 49m
LATAM Airlines
Deal found 3/4![LATAM Airlines logo]()
$1,031
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated March 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:42 am
CLT
- SCL
2 stops50h 58m
Multiple Airlines
Sat 5/308:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$615
This Mytrip deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops31h 00m
Multiple Airlines
Thu 4/238:20 pm
SCL
- CLT
3 stops25h 41m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$587
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/78:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$582
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Sun 5/310:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$620
This Mytrip deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- SCL
2 stops31h 00m
Multiple Airlines
Mon 4/2711:35 am
SCL
- CLT
2 stops21h 35m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$623
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- SCL
3 stops28h 35m
Multiple Airlines
Thu 5/711:00 pm
SCL
- CLT
1 stop12h 45m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$626
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Wed 5/610:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$579
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/711:00 pm
SCL
- CLT
1 stop14h 43m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$585
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Sun 5/310:30 am
SCL
- CLT
1 stop25h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$618
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:14 am
CHS
- SCL
1 stop19h 51m
American Airlines
Thu 4/308:35 pm
SCL
- CHS
1 stop13h 59m
American Airlines
Deal found 3/6![American Airlines logo]()
$833
This KAYAK deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:36 pm
CHS
- SCL
3 stops20h 49m
LATAM Airlines
Thu 4/305:40 am
SCL
- CHS
2 stops18h 42m
LATAM Airlines
Deal found 3/6![LATAM Airlines logo]()
$838
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 am
CLT
- SCL
2 stops23h 00m
Multiple Airlines
Thu 5/78:30 am
SCL
- CLT
2 stops27h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$598
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:18 pm
GSP
- SCL
2 stops32h 52m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/52:54 pm
CLT
- SCL
2 stops38h 36m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/91:53 pm
SAV
- SCL
3 stops31h 12m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/310:43 pm
CLT
- SCL
2 stops52h 17m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:51 pm
CHS
- SCL
1 stop36h 34m
Delta
Deal found 3/7![Delta logo]()
$418
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:52 am
GSP
- SCL
2 stops20h 13m
American Airlines
Deal found 3/8![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:45 pm
GSP
- SCL
1 stop12h 20m
American Airlines
Deal found 3/6![American Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/42:47 pm
CLT
- SCL
2 stops16h 28m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$438
This Expedia deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:06 am
GSP
- SCL
3 stops26h 19m
LATAM Airlines
Deal found 3/8![LATAM Airlines logo]()
$438
This BusinessClass deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:52 pm
CLT
- SCL
1 stop34h 33m
LATAM Airlines
Deal found 3/7![LATAM Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/42:31 pm
CHS
- SCL
1 stop16h 44m
Delta
Deal found 3/7![Delta logo]()
$444
This FlightHub deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/43:26 pm
CLT
- SCL
1 stop14h 59m
LATAM Airlines
Deal found 3/7![LATAM Airlines logo]()
$455
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated March 8, 2026.
Round-trip from | $579 (Kiwi.com) |
|---|---|
One-way from | $342 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 4/20
6:30 am-1:30 pm
2 stops31h 00m
Santiago Arturo Merino Benitez
Mon 4/27
11:35 am-9:10 am
2 stops21h 35m
$623
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 4/18
7:12 am-1:30 pm
3 stops30h 18m
Santiago Arturo Merino Benitez
Sat 4/25
3:20 pm-8:49 pm
2 stops29h 29m
$698
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 7/31
7:44 pm-11:26 pm
2 stops27h 42m
Santiago Arturo Merino Benitez
Tue 8/11
2:27 am-9:42 am
2 stops31h 15m
$778
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 8/2
7:59 pm-7:45 pm
2 stops23h 46m
Santiago Arturo Merino Benitez
Wed 8/12
6:00 pm-6:17 pm
3 stops24h 17m
$830
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 7/29
7:40 am-6:00 am
2 stops22h 20m
Santiago Arturo Merino Benitez
Wed 8/12
6:00 pm-6:17 pm
3 stops24h 17m
$830
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 7/29
5:30 am-7:15 am
1 stop25h 45m
Santiago Arturo Merino Benitez
Wed 8/12
8:40 pm-6:17 pm
1 stop21h 37m
$832
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 5/18
7:20 am-6:00 am
2 stops22h 40m
Santiago Arturo Merino Benitez
Tue 5/26
4:10 am-11:59 pm
2 stops19h 49m
$833
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 3/23
5:05 pm-11:15 am
1 stop17h 10m
Santiago Arturo Merino Benitez
Wed 3/25
7:55 pm-8:57 pm
1 stop26h 02m
$843
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 5/18
11:14 am-7:05 am
1 stop19h 51m
Santiago Arturo Merino Benitez
Tue 6/2
8:35 pm-6:50 pm
1 stop22h 15m
$854
Quickest round-trip
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Wed 4/1
5:41 pm-8:15 am
1 stop13h 34m
Santiago Arturo Merino Benitez
Wed 4/15
8:40 pm-12:21 pm
1 stop15h 41m
$868
Showing 1-10 of 40 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on March 8, 2026.
Popular flight searches
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 8, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$532 | Average$886 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$562 | Average$901 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$845 | FlexibilityNo cancel fee | On-time71% |