$254+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Mar 7 — Mar 141
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Mon 3/239:05 pm
SCL
- CLT
2 stops16h 02m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$553
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/181:20 pm
CLT
- SCL
2 stops20h 19m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$561
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Fri 4/36:00 am
SCL
- CLT
2 stops31h 07m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$576
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:55 am
CLT
- SCL
2 stops26h 35m
Multiple Airlines
Mon 4/611:00 pm
SCL
- CLT
1 stop25h 25m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$577
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:55 am
CLT
- SCL
2 stops19h 01m
Multiple Airlines
Thu 5/148:20 pm
SCL
- CLT
2 stops24h 09m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$578
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$639
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:07 am
CHS
- SCL
2 stops25h 32m
Multiple Airlines
Thu 3/262:09 am
SCL
- CHS
3 stops21h 04m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$694
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2711:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$716
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:55 pm
CHS
- SCL
1 stop11h 45m
Delta
Wed 11/1811:25 pm
SCL
- CHS
2 stops19h 26m
Delta
Deal found 2/3![Delta logo]()
$725
This Travelocity deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:15 pm
CHS
- SCL
1 stop19h 00m
LATAM Airlines
Wed 6/1011:05 pm
SCL
- CHS
2 stops24h 52m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$750
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:35 pm
SAV
- SCL
1 stop15h 15m
United Airlines
Tue 12/810:45 pm
SCL
- SAV
1 stop20h 55m
United Airlines
Deal found 2/2![United Airlines logo]()
$775
This Ovago deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:41 pm
GSP
- SCL
1 stop13h 34m
LATAM Airlines
Wed 4/158:40 pm
SCL
- GSP
1 stop12h 29m
LATAM Airlines
Deal found 2/4![LATAM Airlines logo]()
$775
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Mon 3/2312:35 pm
SCL
- CLT
2 stops24h 32m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$553
This Travelocity deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:15 pm
CHS
- SCL
1 stop19h 00m
LATAM Airlines
Wed 6/1011:05 pm
SCL
- CHS
2 stops24h 52m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$750
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
Delta
Wed 4/111:55 pm
SCL
- SAV
1 stop23h 08m
Delta
Deal found 2/2![Delta logo]()
$820
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:59 pm
SAV
- SCL
1 stop13h 51m
American Airlines
Sat 4/118:35 pm
SCL
- SAV
1 stop13h 47m
American Airlines
Deal found 2/5![American Airlines logo]()
$976
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/181:20 pm
CLT
- SCL
2 stops20h 19m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$561
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Fri 4/36:00 am
SCL
- CLT
2 stops31h 07m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$576
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:55 am
CLT
- SCL
2 stops19h 01m
Multiple Airlines
Thu 5/148:20 pm
SCL
- CLT
2 stops24h 09m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$578
This Ovago deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:41 pm
GSP
- SCL
1 stop13h 34m
LATAM Airlines
Wed 4/158:40 pm
SCL
- GSP
1 stop12h 29m
LATAM Airlines
Deal found 2/4![LATAM Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:41 pm
GSP
- SCL
1 stop13h 34m
Delta
Wed 4/158:40 pm
SCL
- GSP
1 stop15h 41m
Delta
Deal found 2/2![Delta logo]()
$820
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$639
This Ovago deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
LATAM Airlines
Wed 4/18:40 pm
SCL
- SAV
1 stop28h 16m
LATAM Airlines
Deal found 2/4![LATAM Airlines logo]()
$784
This LATAM Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:35 pm
CHS
- SCL
1 stop14h 40m
LATAM Airlines
Sun 5/34:30 pm
SCL
- CHS
2 stops31h 52m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$797
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:07 am
CHS
- SCL
2 stops25h 32m
Multiple Airlines
Thu 3/262:09 am
SCL
- CHS
3 stops21h 04m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$694
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:45 am
GSP
- SCL
2 stops23h 15m
LATAM Airlines
Fri 7/318:40 pm
SCL
- GSP
1 stop19h 33m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$815
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2711:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$716
This Gurufare deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:41 pm
GSP
- SCL
1 stop12h 59m
LATAM Airlines
Thu 3/2610:25 pm
SCL
- GSP
1 stop13h 40m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$820
This Gurufare deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:59 pm
GSP
- SCL
2 stops32h 56m
LATAM Airlines
Sun 3/298:55 pm
SCL
- GSP
2 stops27h 59m
LATAM Airlines
Deal found 2/5![LATAM Airlines logo]()
$825
This Gurufare deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:54 pm
MYR
- SCL
1 stop11h 46m
LATAM Airlines
Thu 3/2612:20 am
SCL
- MYR
2 stops34h 13m
LATAM Airlines
Deal found 2/3![LATAM Airlines logo]()
$900
This LATAM Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
MYR
- SCL
2 stops22h 35m
LATAM Airlines
Thu 3/1912:20 am
SCL
- MYR
2 stops24h 44m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$920
This BusinessClass deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:59 am
SAV
- SCL
2 stops30h 36m
LATAM Airlines
Sat 4/1111:05 pm
SCL
- SAV
2 stops34h 22m
LATAM Airlines
Deal found 2/5![LATAM Airlines logo]()
$949
This Expedia deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:10 am
SAV
- SCL
2 stops41h 10m
Multiple Airlines
Sat 4/118:30 am
SCL
- SAV
3 stops27h 08m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$1,316
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated February 5, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated February 5, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$639
This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Mon 3/239:05 pm
SCL
- CLT
2 stops16h 02m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$553
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/181:20 pm
CLT
- SCL
2 stops20h 19m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$561
This Gurufare deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:41 pm
GSP
- SCL
1 stop12h 59m
LATAM Airlines
Thu 3/2610:25 pm
SCL
- GSP
1 stop13h 40m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$820
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:07 am
CHS
- SCL
2 stops25h 32m
Multiple Airlines
Thu 3/262:09 am
SCL
- CHS
3 stops21h 04m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$694
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2711:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$716
This eDestinos deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2110:42 am
CLT
- SCL
2 stops50h 58m
Multiple Airlines
Sat 3/2812:35 pm
SCL
- CLT
2 stops46h 37m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$587
This Gurufare deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/225:41 pm
GSP
- SCL
1 stop12h 59m
LATAM Airlines
Sun 3/298:55 pm
SCL
- GSP
2 stops22h 59m
LATAM Airlines
Deal found 2/5![LATAM Airlines logo]()
$860
This Ovago deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
LATAM Airlines
Wed 4/18:40 pm
SCL
- SAV
1 stop28h 16m
LATAM Airlines
Deal found 2/4![LATAM Airlines logo]()
$784
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
Delta
Wed 4/111:55 pm
SCL
- SAV
1 stop23h 08m
Delta
Deal found 2/2![Delta logo]()
$820
This Mytrip deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Fri 4/36:00 am
SCL
- CLT
2 stops31h 07m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$576
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Tue 4/284:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$600
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
CLT
- SCL
2 stops27h 39m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$254
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/253:25 pm
CLT
- SCL
1 stop13h 30m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$380
This eDestinos deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:37 pm
CLT
- SCL
2 stops38h 03m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/113:44 pm
CLT
- SCL
1 stop14h 31m
American Airlines
Deal found 2/4![American Airlines logo]()
$466
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/157:44 pm
CLT
- SCL
2 stops35h 06m
United Airlines
Deal found 2/2![United Airlines logo]()
$469
This LATAM Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/152:26 pm
CLT
- SCL
3 stops22h 04m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$502
This Priceline deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/165:55 pm
SAV
- SCL
2 stops18h 35m
LATAM Airlines
Deal found 2/4![LATAM Airlines logo]()
$561
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/164:06 pm
SAV
- SCL
3 stops33h 54m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$594
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated February 5, 2026.
Round-trip from | $553 (Mytrip) |
|---|---|
One-way from | $254 (Mytrip) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
South Carolina
Fly to
Santiago
Route
Depart
Return
Price
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 3/16
7:00 am-12:00 pm
3 stops28h 00m
Santiago Arturo Merino Benitez
Mon 3/23
12:35 pm-12:07 pm
2 stops24h 32m
$553
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/18
1:20 pm-10:39 am
2 stops20h 19m
Santiago Arturo Merino Benitez
Wed 3/25
5:50 am-12:07 pm
2 stops31h 17m
$561
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 3/27
7:00 am-12:00 pm
3 stops28h 00m
Santiago Arturo Merino Benitez
Fri 4/3
6:00 am-12:07 pm
2 stops31h 07m
$576
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 4/27
8:55 am-3:56 am
2 stops19h 01m
Santiago Arturo Merino Benitez
Thu 5/14
8:20 pm-8:29 pm
2 stops24h 09m
$578
Myrtle BeachSantiago
MYR - SCL
MYRSCL
Myrtle Beach Intl
Sat 3/14
9:49 pm-2:40 pm
3 stops39h 51m
Santiago Arturo Merino Benitez
Fri 3/20
11:24 am-5:33 pm
2 stops31h 09m
$639
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Fri 3/20
8:07 am-10:39 am
2 stops25h 32m
Santiago Arturo Merino Benitez
Thu 3/26
2:09 am-10:13 pm
3 stops21h 04m
$694
Myrtle BeachSantiago
MYR - SCL
MYRSCL
Myrtle Beach Intl
Fri 3/20
9:49 pm-2:40 pm
3 stops39h 51m
Santiago Arturo Merino Benitez
Fri 3/27
11:24 am-5:33 pm
2 stops31h 09m
$716
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 6/3
12:15 pm-7:15 am
1 stop19h 00m
Santiago Arturo Merino Benitez
Wed 6/10
11:05 pm-11:57 pm
2 stops24h 52m
$750
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Wed 4/1
5:41 pm-8:15 am
1 stop13h 34m
Santiago Arturo Merino Benitez
Wed 4/15
8:40 pm-9:09 am
1 stop12h 29m
$775
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
Mon 3/23
4:57 pm-7:40 am
1 stop13h 43m
Santiago Arturo Merino Benitez
Wed 4/1
8:40 pm-11:56 pm
1 stop28h 16m
$784
Showing 1-10 of 29 results
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
SAV-SCL
MYR-SCL
CHS-SCL
GSP-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
SAV-SCL
MYR-SCL
CHS-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on February 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 5, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$532 | Average$888 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$562 | Average$901 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$845 | FlexibilityNo cancel fee | On-time71% |