$283+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
May 8 — May 151
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:58 pm
CLT
- SCL
3 stops34h 02m
Multiple Airlines
Wed 5/135:00 am
SCL
- CLT
2 stops36h 13m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$653
This Mytrip deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:48 pm
CLT
- SCL
2 stops16h 42m
Multiple Airlines
Thu 5/143:20 pm
SCL
- CLT
2 stops20h 23m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$677
This Mytrip deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:54 pm
CLT
- SCL
3 stops29h 06m
Multiple Airlines
Fri 5/13:20 pm
SCL
- CLT
2 stops29h 29m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$703
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
CLT
- SCL
2 stops21h 25m
Multiple Airlines
Sun 5/106:40 am
SCL
- CLT
2 stops29h 03m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$715
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:45 am
CHS
- SCL
2 stops22h 15m
LATAM Airlines
Sun 8/234:30 pm
SCL
- CHS
2 stops26h 26m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$875
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:59 pm
CHS
- SCL
2 stops32h 11m
Multiple Airlines
Thu 5/711:17 am
SCL
- CHS
2 stops49h 33m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$953
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
MYR
- SCL
3 stops45h 47m
Multiple Airlines
Sat 5/303:20 pm
SCL
- MYR
2 stops29h 16m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$978
This KAYAK deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:23 am
CHS
- SCL
3 stops26h 02m
LATAM Airlines
Tue 6/3011:00 pm
SCL
- CHS
2 stops18h 38m
LATAM Airlines
Deal found 4/5![LATAM Airlines logo]()
$990
This KAYAK deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:25 am
CHS
- SCL
2 stops30h 10m
LATAM Airlines
Wed 5/137:50 am
SCL
- CHS
2 stops16h 09m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$1,117
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:45 pm
GSP
- SCL
1 stop12h 20m
American Airlines
Wed 5/279:00 pm
SCL
- GSP
2 stops19h 35m
American Airlines
Deal found 4/5![American Airlines logo]()
$1,130
This Expedia deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:42 am
SAV
- SCL
2 stops36h 38m
Multiple Airlines
Thu 5/147:50 am
SCL
- SAV
2 stops15h 50m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$1,158
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:52 am
SAV
- SCL
1 stop20h 13m
American Airlines
Thu 5/148:35 pm
SCL
- SAV
1 stop13h 47m
American Airlines
Deal found 4/6![American Airlines logo]()
$1,175
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
This Mytrip deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:48 pm
CLT
- SCL
3 stops22h 17m
Multiple Airlines
Thu 5/146:40 am
SCL
- CLT
3 stops41h 00m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$745
This KAYAK deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/154:30 pm
CHS
- SCL
1 stop14h 45m
LATAM Airlines
Sun 8/2311:05 pm
SCL
- CHS
2 stops24h 52m
LATAM Airlines
Deal found 4/8![LATAM Airlines logo]()
$875
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:22 pm
CLT
- SCL
1 stop16h 53m
Delta
Wed 8/58:40 pm
SCL
- CLT
1 stop19h 37m
Delta
Deal found 4/5![Delta logo]()
$975
This Copa Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:44 pm
CLT
- SCL
2 stops26h 59m
Copa Airlines
Thu 8/202:56 am
SCL
- CLT
2 stops30h 46m
Copa Airlines
Deal found 4/7![Copa Airlines logo]()
$978
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:52 am
GSP
- SCL
2 stops20h 13m
American Airlines
Wed 5/279:00 pm
SCL
- GSP
2 stops17h 07m
American Airlines
Deal found 4/5![American Airlines logo]()
$1,130
This FlightHub deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:52 pm
CLT
- SCL
1 stop16h 33m
LATAM Airlines
Fri 8/2110:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 4/4![LATAM Airlines logo]()
$912
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
MYR
- SCL
3 stops45h 47m
Multiple Airlines
Sat 5/303:20 pm
SCL
- MYR
2 stops29h 16m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$978
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2912:19 pm
CLT
- SCL
1 stop18h 56m
Delta
Sat 8/810:55 pm
SCL
- CLT
1 stop24h 12m
Delta
Deal found 4/5![Delta logo]()
$1,025
This KAYAK deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1511:23 am
CHS
- SCL
2 stops18h 02m
LATAM Airlines
Tue 6/3011:00 pm
SCL
- CHS
2 stops18h 38m
LATAM Airlines
Deal found 4/5![LATAM Airlines logo]()
$990
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:48 pm
CLT
- SCL
1 stop16h 47m
Multiple Airlines
Fri 5/298:20 pm
SCL
- CLT
2 stops39h 23m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$1,012
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2812:19 pm
CLT
- SCL
1 stop18h 56m
Delta
Sun 8/910:55 pm
SCL
- CLT
1 stop14h 57m
Delta
Deal found 4/5![Delta logo]()
$1,025
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:12 pm
GSP
- SCL
1 stop18h 53m
American Airlines
Sat 6/69:00 pm
SCL
- GSP
2 stops20h 35m
American Airlines
Deal found 4/4![American Airlines logo]()
$1,180
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:20 pm
CLT
- SCL
1 stop35h 05m
Delta
Sun 8/910:55 pm
SCL
- CLT
1 stop23h 28m
Delta
Deal found 4/5![Delta logo]()
$1,034
This Justfly.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:45 am
CLT
- SCL
1 stop20h 40m
LATAM Airlines
Sun 6/76:45 pm
SCL
- CLT
2 stops18h 25m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$1,048
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:13 pm
CHS
- SCL
2 stops14h 52m
American Airlines
Fri 5/299:00 pm
SCL
- CHS
2 stops20h 48m
American Airlines
Deal found 4/6![American Airlines logo]()
$1,180
This Trip.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
CLT
- SCL
1 stop24h 25m
Multiple Airlines
Sun 5/1010:30 am
SCL
- CLT
1 stop25h 13m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$1,078
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:09 pm
CHS
- SCL
1 stop10h 56m
American Airlines
Tue 6/309:00 pm
SCL
- CHS
1 stop22h 29m
American Airlines
Deal found 4/5![American Airlines logo]()
$1,205
This LATAM Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:25 pm
CHS
- SCL
3 stops22h 24m
LATAM Airlines
Wed 5/135:40 am
SCL
- CHS
2 stops18h 19m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$1,123
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:54 pm
SAV
- SCL
1 stop17h 21m
Delta
Tue 5/1210:55 pm
SCL
- SAV
1 stop19h 22m
Delta
Deal found 4/5![Delta logo]()
$1,255
This KAYAK deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:09 pm
GSP
- SCL
2 stops16h 51m
LATAM Airlines
Mon 6/88:40 pm
SCL
- GSP
1 stop14h 10m
LATAM Airlines
Deal found 4/4![LATAM Airlines logo]()
$1,203
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:06 am
GSP
- SCL
1 stop20h 09m
Delta
Tue 5/58:40 pm
SCL
- GSP
1 stop12h 29m
Delta
Deal found 4/7![Delta logo]()
$1,270
This KAYAK deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:45 am
GSP
- SCL
3 stops28h 04m
LATAM Airlines
Sat 6/66:00 pm
SCL
- GSP
2 stops16h 50m
LATAM Airlines
Deal found 4/4![LATAM Airlines logo]()
$1,207
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:59 pm
GSP
- SCL
1 stop11h 16m
Delta
Mon 5/1110:55 pm
SCL
- GSP
1 stop15h 55m
Delta
Deal found 4/7![Delta logo]()
$1,270
This LATAM Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:25 pm
CHS
- SCL
3 stops21h 39m
LATAM Airlines
Thu 4/238:40 pm
SCL
- CHS
1 stop13h 29m
LATAM Airlines
Deal found 4/4![LATAM Airlines logo]()
$1,245
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:35 am
GSP
- SCL
1 stop18h 50m
Delta
Wed 5/68:40 pm
SCL
- GSP
1 stop12h 24m
Delta
Deal found 4/7![Delta logo]()
$1,270
This Expedia deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:09 pm
GSP
- SCL
3 stops45h 40m
LATAM Airlines
Wed 5/274:10 am
SCL
- GSP
2 stops19h 33m
LATAM Airlines
Deal found 4/5![LATAM Airlines logo]()
$1,246
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:50 pm
GSP
- SCL
1 stop13h 25m
Delta
Thu 5/710:55 pm
SCL
- GSP
1 stop18h 39m
Delta
Deal found 4/7![Delta logo]()
$1,270
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:53 pm
SAV
- SCL
1 stop12h 22m
Delta
Fri 5/158:40 pm
SCL
- SAV
1 stop12h 40m
Delta
Deal found 4/5![Delta logo]()
$1,305
This KAYAK deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
MYR
- SCL
2 stops24h 25m
LATAM Airlines
Sat 5/308:40 pm
SCL
- MYR
1 stop13h 59m
LATAM Airlines
Deal found 4/4![LATAM Airlines logo]()
$1,330
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:49 pm
SAV
- SCL
1 stop12h 26m
Delta
Sat 5/168:40 pm
SCL
- SAV
1 stop12h 51m
Delta
Deal found 4/5![Delta logo]()
$1,305
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated April 8, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated April 8, 2026 and is based on user searches.
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:59 pm
CHS
- SCL
2 stops32h 11m
Multiple Airlines
Thu 5/711:17 am
SCL
- CHS
2 stops49h 33m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$953
This Mytrip deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:54 pm
CLT
- SCL
3 stops29h 06m
Multiple Airlines
Fri 5/13:20 pm
SCL
- CLT
2 stops29h 29m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$703
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
CLT
- SCL
2 stops21h 25m
Multiple Airlines
Sun 5/106:40 am
SCL
- CLT
2 stops29h 03m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$715
This Expedia deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:42 am
SAV
- SCL
2 stops36h 38m
Multiple Airlines
Thu 5/147:50 am
SCL
- SAV
2 stops15h 50m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$1,158
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:52 am
SAV
- SCL
1 stop20h 13m
American Airlines
Thu 5/148:35 pm
SCL
- SAV
1 stop13h 47m
American Airlines
Deal found 4/6![American Airlines logo]()
$1,175
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:58 pm
CLT
- SCL
3 stops34h 02m
Multiple Airlines
Wed 5/135:00 am
SCL
- CLT
2 stops36h 13m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$653
This KAYAK deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:25 am
CHS
- SCL
2 stops30h 10m
LATAM Airlines
Wed 5/137:50 am
SCL
- CHS
2 stops16h 09m
LATAM Airlines
Deal found 4/7![LATAM Airlines logo]()
$1,117
This Mytrip deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:48 pm
CLT
- SCL
2 stops16h 42m
Multiple Airlines
Thu 5/143:20 pm
SCL
- CLT
2 stops20h 23m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:52 am
GSP
- SCL
2 stops20h 13m
American Airlines
Wed 5/279:00 pm
SCL
- GSP
2 stops17h 07m
American Airlines
Deal found 4/5![American Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:13 pm
CHS
- SCL
2 stops14h 52m
American Airlines
Fri 5/299:00 pm
SCL
- CHS
2 stops20h 48m
American Airlines
Deal found 4/6![American Airlines logo]()
$1,180
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
MYR
- SCL
3 stops45h 47m
Multiple Airlines
Sat 5/303:20 pm
SCL
- MYR
2 stops29h 16m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$978
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3011:15 am
GSP
- SCL
2 stops19h 50m
American Airlines
Sat 6/69:00 pm
SCL
- GSP
2 stops17h 07m
American Airlines
Deal found 4/4![American Airlines logo]()
$1,180
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
This Trip.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:22 am
CLT
- SCL
2 stops27h 13m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1910:38 am
GSP
- SCL
2 stops17h 17m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:31 pm
CLT
- SCL
2 stops22h 44m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:16 pm
CLT
- SCL
3 stops28h 07m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$373
This FlightHub deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:21 pm
CLT
- SCL
1 stop15h 04m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$556
This FlightHub deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:21 pm
CLT
- SCL
1 stop15h 04m
LATAM Airlines
Deal found 4/6![LATAM Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:45 pm
GSP
- SCL
1 stop12h 20m
American Airlines
Deal found 4/5![American Airlines logo]()
$677
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated April 8, 2026.
Round-trip from | $653 (eDestinos) |
|---|---|
One-way from | $283 (Trip.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 5/7
12:48 pm-11:05 am
3 stops22h 17m
Santiago Arturo Merino Benitez
Thu 5/14
6:40 am-11:40 pm
3 stops41h 00m
$745
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sat 8/15
4:30 pm-7:15 am
1 stop14h 45m
Santiago Arturo Merino Benitez
Sun 8/23
11:05 pm-11:57 pm
2 stops24h 52m
$875
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 8/7
1:52 pm-6:25 am
1 stop16h 33m
Santiago Arturo Merino Benitez
Fri 8/21
10:55 pm-1:52 pm
1 stop14h 57m
$912
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/28
2:22 pm-7:15 am
1 stop16h 53m
Santiago Arturo Merino Benitez
Wed 8/5
8:40 pm-4:17 pm
1 stop19h 37m
$975
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 8/7
7:44 pm-10:43 pm
2 stops26h 59m
Santiago Arturo Merino Benitez
Thu 8/20
2:56 am-9:42 am
2 stops30h 46m
$978
Myrtle BeachSantiago
MYR - SCL
MYRSCL
Myrtle Beach Intl
Sat 5/23
6:30 am-4:17 am
3 stops45h 47m
Santiago Arturo Merino Benitez
Sat 5/30
3:20 pm-8:36 pm
2 stops29h 16m
$978
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 6/15
11:23 am-5:25 am
2 stops18h 02m
Santiago Arturo Merino Benitez
Tue 6/30
11:00 pm-5:38 pm
2 stops18h 38m
$990
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 5/22
12:48 pm-5:35 am
1 stop16h 47m
Santiago Arturo Merino Benitez
Fri 5/29
8:20 pm-11:43 am
2 stops39h 23m
$1,012
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 7/29
12:19 pm-7:15 am
1 stop18h 56m
Santiago Arturo Merino Benitez
Sat 8/8
10:55 pm-11:07 pm
1 stop24h 12m
$1,025
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/28
12:19 pm-7:15 am
1 stop18h 56m
Santiago Arturo Merino Benitez
Sun 8/9
10:55 pm-1:52 pm
1 stop14h 57m
$1,025
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on April 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 8, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$753 | Average$948 | FlexibilityNo cancel fee | On-timeN/A |