$419+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:13 pm -
1 stop13h 37m
Tue 12/810:45 pm -
1 stop19h 33m
Deal found 10/17![United Airlines logo]()
$1,126
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:04 pm -
2 stops17h 21m
Tue 12/811:15 pm -
2 stops17h 43m
Deal found 10/17![American Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:47 pm -
2 stops18h 38m
Mon 12/710:30 pm -
2 stops20h 07m
Deal found 10/16![American Airlines logo]()
$1,181
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:08 pm -
1 stop11h 02m
Tue 10/2710:15 pm -
2 stops22h 42m
Deal found 10/15![GOL logo]()
$1,182
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:12 pm -
1 stop13h 38m
Sat 11/1410:45 pm -
1 stop19h 25m
Deal found 10/18![United Airlines logo]()
$1,186
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:56 pm -
2 stops34h 54m
Sun 12/2010:45 pm -
2 stops38h 08m
Deal found 10/18![United Airlines logo]()
$1,190
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:00 pm -
1 stop15h 40m
Sat 11/1411:10 pm -
1 stop12h 37m
Deal found 10/18![Delta logo]()
$1,196
This Expedia deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop22h 40m
Sun 12/205:55 pm -
2 stops21h 55m
Deal found 10/18![Multiple Airlines logo]()
$1,196
This Cheapflightsfares deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop22h 40m
Sun 12/2011:00 pm -
1 stop19h 52m
Deal found 10/18![LATAM Airlines logo]()
$1,200
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:37 pm -
2 stops17h 08m
Sat 11/1410:30 pm -
2 stops19h 57m
Deal found 10/16![American Airlines logo]()
$1,220
This LATAM Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:18 pm -
1 stop15h 22m
Mon 12/79:50 pm -
1 stop22h 13m
Deal found 10/16![LATAM Airlines logo]()
$1,238
This LATAM Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:05 am -
2 stops21h 40m
Mon 10/2612:48 am -
2 stops18h 21m
Deal found 10/15![LATAM Airlines logo]()
$1,246
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This Ovago deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:00 am -
2 stops21h 59m
Mon 3/81:16 am -
2 stops21h 57m
Deal found 10/20![Copa Airlines logo]()
$1,120
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2911:16 am -
2 stops19h 44m
Mon 2/110:15 pm -
2 stops18h 51m
Deal found 10/18![American Airlines logo]()
$1,130
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:51 pm -
2 stops34h 59m
Mon 2/2210:45 pm -
1 stop19h 27m
Deal found 10/18![United Airlines logo]()
$1,130
This LATAM Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/243:42 pm -
2 stops24h 18m
Sun 3/74:35 pm -
2 stops28h 14m
Deal found 10/17![LATAM Airlines logo]()
$1,166
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:00 am -
1 stop22h 55m
Tue 3/911:50 pm -
1 stop22h 52m
Deal found 10/20![Delta logo]()
$1,176
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:00 am -
2 stops24h 50m
Tue 3/910:45 pm -
2 stops22h 25m
Deal found 10/17![United Airlines logo]()
$1,160
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:47 pm -
2 stops18h 38m
Mon 12/710:30 pm -
2 stops20h 07m
Deal found 10/16![American Airlines logo]()
$1,181
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:00 pm -
1 stop15h 40m
Sat 11/1411:10 pm -
1 stop12h 37m
Deal found 10/18![Delta logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:52 am -
3 stops26h 08m
Mon 12/711:10 pm -
2 stops16h 23m
Deal found 10/16![LATAM Airlines logo]()
$1,242
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:12 pm -
1 stop13h 38m
Sat 11/1410:45 pm -
1 stop19h 25m
Deal found 10/18![United Airlines logo]()
$1,186
This oojo deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/15:25 pm -
2 stops28h 56m
Mon 2/228:35 am -
3 stops33h 40m
Deal found 10/18![LATAM Airlines logo]()
$1,381
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:51 pm -
2 stops34h 59m
Thu 1/2110:45 pm -
2 stops27h 14m
Deal found 10/17![United Airlines logo]()
$1,502
This LATAM Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/296:45 pm -
2 stops19h 20m
Thu 4/17:00 pm -
2 stops23h 55m
Deal found 10/16![LATAM Airlines logo]()
$1,612
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated October 20, 2026 and is based on user searches.
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:08 pm -
1 stop11h 02m
Tue 10/2710:15 pm -
2 stops22h 42m
Deal found 10/15![GOL logo]()
$1,182
This LATAM Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:05 am -
2 stops21h 40m
Mon 10/2612:48 am -
2 stops18h 21m
Deal found 10/15![LATAM Airlines logo]()
$1,246
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:12 pm -
1 stop13h 38m
Sat 11/1410:45 pm -
1 stop19h 25m
Deal found 10/18![United Airlines logo]()
$1,186
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:00 pm -
1 stop15h 40m
Sat 11/1411:10 pm -
1 stop12h 37m
Deal found 10/18![Delta logo]()
$1,196
This SmartFares deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:45 am -
2 stops17h 15m
Sat 11/148:35 am -
3 stops27h 12m
Deal found 10/18![LATAM Airlines logo]()
$1,250
This Expedia deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:25 pm -
2 stops31h 20m
Wed 11/254:15 pm -
2 stops20h 10m
Deal found 10/17![Multiple Airlines logo]()
$5,934
This Expedia deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:12 pm -
2 stops30h 36m
Wed 11/2511:50 pm -
1 stop18h 37m
Deal found 10/17![LATAM Airlines logo]()
$6,152
This BusinessClass deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 pm -
1 stop13h 50m
Wed 11/2510:45 pm -
1 stop19h 26m
Deal found 10/17![Avianca logo]()
$10,155
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:37 pm -
2 stops17h 08m
Sat 11/1410:30 pm -
2 stops19h 57m
Deal found 10/16![American Airlines logo]()
$1,220
This Travelocity deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:05 am -
2 stops20h 50m
Sat 11/148:35 am -
3 stops35h 39m
Deal found 10/16![LATAM Airlines logo]()
$1,261
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:47 pm -
2 stops18h 38m
Mon 12/710:30 pm -
2 stops20h 07m
Deal found 10/16![American Airlines logo]()
$1,181
This LATAM Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:18 pm -
1 stop15h 22m
Mon 12/79:50 pm -
1 stop22h 13m
Deal found 10/16![LATAM Airlines logo]()
$1,238
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This eDestinos deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:08 pm -
3 stops36h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:30 am -
2 stops19h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$772
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![LATAM Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
2 stops18h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Delta logo]()
$786
This KAYAK deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:12 am -
2 stops31h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Copa Airlines logo]()
$2,993
This BusinessClass deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Avianca logo]()
$3,339
This BusinessClass deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:18 pm -
3 stops29h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![LATAM Airlines logo]()
$3,364
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![United Airlines logo]()
$6,289
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 20, 2026.
Round-trip from | $1,120 (Ovago) |
|---|---|
One-way from | $419 (eDestinos) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
11:30 am-8:50 am
2 stops19h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$772
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$775
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-6:55 am
2 stops18h 03m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$786
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sat 2/20
6:00 am-5:59 am
2 stops21h 59m
Santiago Arturo Merino Benitez
Mon 3/8
1:16 am-9:13 pm
2 stops21h 57m
$1,120
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 1/29
11:16 am-9:00 am
2 stops19h 44m
Santiago Arturo Merino Benitez
Mon 2/1
10:15 pm-3:06 pm
2 stops18h 51m
$1,130
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Mon 2/1
7:51 pm-8:50 am
2 stops34h 59m
Santiago Arturo Merino Benitez
Mon 2/22
10:45 pm-4:12 pm
1 stop19h 27m
$1,130
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sat 2/20
6:00 am-8:50 am
2 stops24h 50m
Santiago Arturo Merino Benitez
Tue 3/9
10:45 pm-7:10 pm
2 stops22h 25m
$1,160
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 2/24
3:42 pm-6:00 pm
2 stops24h 18m
Santiago Arturo Merino Benitez
Sun 3/7
4:35 pm-6:49 pm
2 stops28h 14m
$1,166
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sat 2/20
6:00 am-6:55 am
1 stop22h 55m
Santiago Arturo Merino Benitez
Tue 3/9
11:50 pm-8:42 pm
1 stop22h 52m
$1,176
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Mon 11/30
12:47 pm-9:25 am
2 stops18h 38m
Santiago Arturo Merino Benitez
Mon 12/7
10:30 pm-4:37 pm
2 stops20h 07m
$1,181
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
MYR-SCL
GSP-SCL
CHS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
MYR-SCL
GSP-SCL
CHS-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
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Complete your trip
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South Carolina and Santiago flights
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Other flights to Santiago
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South Carolina to Santiago flights
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Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$1,134 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$763 | Average$974 | FlexibilityNo cancel fee | On-timeN/A |