$333+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Sep 3 — Sep 101
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:32 am -
2 stops17h 24m
Mon 9/2111:55 pm -
1 stop22h 19m
Deal found 7/31![Multiple Airlines logo]()
$778
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:56 am -
2 stops37h 43m
Tue 9/811:55 pm -
1 stop15h 00m
Deal found 8/3![Multiple Airlines logo]()
$782
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:16 pm -
2 stops31h 40m
Sun 9/2011:55 pm -
1 stop22h 19m
Deal found 7/30![Multiple Airlines logo]()
$784
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:32 am -
2 stops17h 24m
Fri 9/1811:55 pm -
1 stop19h 27m
Deal found 7/30![Multiple Airlines logo]()
$794
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops17h 24m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/3![Multiple Airlines logo]()
$814
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:32 am -
2 stops28h 03m
Sun 9/2711:55 pm -
1 stop22h 19m
Deal found 7/31![Multiple Airlines logo]()
$850
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:59 pm -
2 stops23h 37m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$856
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:59 pm -
2 stops31h 36m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$857
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/279:59 pm -
2 stops31h 36m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$859
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:30 pm -
1 stop13h 55m
Tue 9/229:30 pm -
1 stop19h 04m
Deal found 8/1![American Airlines logo]()
$905
This oojo deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:43 pm -
2 stops17h 12m
Thu 9/2411:55 pm -
2 stops18h 52m
Deal found 8/3![LATAM Airlines logo]()
$909
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:40 am -
2 stops22h 00m
Tue 9/228:55 pm -
2 stops15h 43m
Deal found 8/1![Delta logo]()
$915
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 pm -
1 stop12h 40m
Thu 9/249:30 pm -
1 stop21h 38m
Deal found 8/3![American Airlines logo]()
$905
This Copa Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:47 pm -
2 stops22h 31m
Wed 1/275:13 am -
2 stops30h 31m
Deal found 8/2![Copa Airlines logo]()
$908
This Expedia deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:05 pm -
1 stop34h 35m
Sun 2/77:30 am -
2 stops32h 24m
Deal found 7/31![LATAM Airlines logo]()
$909
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:40 am -
2 stops22h 00m
Tue 9/228:55 pm -
2 stops15h 43m
Deal found 8/1![Delta logo]()
$915
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:30 am -
2 stops24h 20m
Tue 11/1010:45 pm -
2 stops26h 14m
Deal found 8/1![United Airlines logo]()
$940
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:33 pm -
2 stops37h 22m
Sun 11/1511:55 pm -
1 stop21h 21m
Deal found 8/1![Multiple Airlines logo]()
$1,018
This Copa Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
2 stops21h 46m
Tue 11/241:22 am -
2 stops34h 40m
Deal found 8/3![Copa Airlines logo]()
$908
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:43 pm -
2 stops36h 07m
Wed 11/410:45 pm -
1 stop19h 43m
Deal found 7/30![United Airlines logo]()
$970
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:00 pm -
1 stop16h 40m
Wed 11/411:10 pm -
1 stop20h 49m
Deal found 7/30![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:20 am -
1 stop19h 20m
Tue 12/228:13 am -
2 stops17h 46m
Deal found 8/3![Delta logo]()
$1,035
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:45 pm -
1 stop12h 30m
Thu 8/2711:22 am -
2 stops27h 22m
Deal found 8/2![Multiple Airlines logo]()
$1,099
This oojo deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:45 pm -
2 stops16h 10m
Tue 12/228:30 am -
3 stops28h 48m
Deal found 8/3![LATAM Airlines logo]()
$1,008
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:45 pm -
1 stop11h 15m
Sun 9/209:30 pm -
1 stop13h 50m
Deal found 7/30![American Airlines logo]()
$1,121
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:23 pm -
1 stop16h 02m
Wed 10/78:40 pm -
1 stop13h 21m
Deal found 7/31![Delta logo]()
$1,084
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:30 pm -
1 stop11h 30m
Tue 9/299:30 pm -
1 stop13h 50m
Deal found 7/31![American Airlines logo]()
$1,129
This LATAM Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:28 pm -
1 stop17h 47m
Thu 8/2711:05 pm -
2 stops20h 04m
Deal found 8/3![LATAM Airlines logo]()
$1,055
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1912:47 pm -
1 stop18h 28m
Mon 8/318:40 pm -
1 stop14h 55m
Deal found 7/31![Delta logo]()
$1,087
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:18 pm -
2 stops25h 42m
Tue 11/1711:10 pm -
1 stop16h 23m
Deal found 7/30![LATAM Airlines logo]()
$1,057
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:59 pm -
1 stop11h 16m
Tue 9/17:50 am -
2 stops16h 31m
Deal found 7/31![Delta logo]()
$1,087
This Expedia deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:20 am -
1 stop18h 20m
Fri 1/227:30 am -
2 stops18h 29m
Deal found 8/3![LATAM Airlines logo]()
$1,068
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:37 pm -
1 stop12h 38m
Thu 9/38:40 pm -
1 stop17h 24m
Deal found 7/31![Delta logo]()
$1,087
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:11 pm -
1 stop16h 04m
Fri 8/288:40 pm -
1 stop12h 36m
Deal found 7/31![Delta logo]()
$1,117
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:37 pm -
1 stop12h 38m
Mon 8/318:40 pm -
1 stop12h 36m
Deal found 8/1![Delta logo]()
$1,117
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:01 pm -
1 stop18h 14m
Thu 8/278:40 pm -
1 stop15h 14m
Deal found 7/30![LATAM Airlines logo]()
$1,287
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:28 am -
1 stop18h 57m
Wed 9/210:55 pm -
1 stop22h 56m
Deal found 7/31![Delta logo]()
$1,117
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:15 am -
1 stop23h 10m
Fri 8/2810:55 pm -
1 stop18h 16m
Deal found 7/31![Delta logo]()
$1,117
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:37 pm -
2 stops19h 28m
Mon 8/248:40 pm -
1 stop17h 24m
Deal found 7/31![Delta logo]()
$1,117
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:11 pm -
1 stop16h 04m
Fri 8/288:40 pm -
1 stop14h 57m
Deal found 7/31![Delta logo]()
$1,117
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:02 pm -
1 stop14h 13m
Tue 12/111:10 pm -
1 stop19h 07m
Deal found 8/3![Delta logo]()
$1,129
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:07 am -
1 stop24h 18m
Mon 11/3011:55 pm -
1 stop21h 01m
Deal found 8/3![Delta logo]()
$1,129
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated August 4, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated August 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:56 am -
2 stops37h 43m
Tue 9/811:55 pm -
1 stop15h 00m
Deal found 8/3![Multiple Airlines logo]()
$782
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:32 am -
2 stops17h 24m
Fri 9/1811:55 pm -
1 stop19h 27m
Deal found 7/30![Multiple Airlines logo]()
$794
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:16 pm -
2 stops31h 40m
Sun 9/2011:55 pm -
1 stop22h 19m
Deal found 7/30![Multiple Airlines logo]()
$784
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:32 am -
2 stops17h 24m
Mon 9/2111:55 pm -
1 stop22h 19m
Deal found 7/31![Multiple Airlines logo]()
$778
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:30 pm -
1 stop13h 55m
Tue 9/229:30 pm -
1 stop19h 04m
Deal found 8/1![American Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:40 am -
2 stops22h 00m
Tue 9/228:55 pm -
2 stops15h 43m
Deal found 8/1![Delta logo]()
$915
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops17h 24m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/3![Multiple Airlines logo]()
$814
This oojo deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:43 pm -
2 stops17h 12m
Thu 9/2411:55 pm -
2 stops18h 52m
Deal found 8/3![LATAM Airlines logo]()
$909
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:32 am -
2 stops28h 03m
Sun 9/2711:55 pm -
1 stop22h 19m
Deal found 7/31![Multiple Airlines logo]()
$850
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/279:59 pm -
2 stops31h 36m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$859
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:59 pm -
2 stops31h 36m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$857
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:00 pm -
2 stops30h 36m
Sun 11/2911:10 pm -
1 stop17h 58m
Deal found 8/3![Multiple Airlines logo]()
$860
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:22 am -
3 stops43h 33m
Deal found 8/1![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:06 pm -
3 stops35h 29m
Deal found 7/30![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:36 am -
2 stops18h 24m
Deal found 8/3![Multiple Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:39 pm -
2 stops20h 36m
Deal found 8/4![Multiple Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:00 am -
2 stops36h 15m
Deal found 8/4![Multiple Airlines logo]()
$485
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/244:49 pm -
3 stops35h 49m
Deal found 7/30![Multiple Airlines logo]()
$525
This oojo deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:28 pm -
1 stop14h 22m
Deal found 8/1![LATAM Airlines logo]()
$556
This LATAM Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:42 am -
2 stops19h 13m
Deal found 7/31![Multiple Airlines logo]()
$577
This oojo deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:45 pm -
1 stop34h 40m
Deal found 8/3![LATAM Airlines logo]()
$614
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:01 am -
2 stops19h 59m
Deal found 8/2![American Airlines logo]()
$635
This SmartFares deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:43 pm -
1 stop11h 57m
Deal found 8/4![LATAM Airlines logo]()
$636
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:25 am -
2 stops19h 25m
Deal found 7/30![United Airlines logo]()
$662
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated August 4, 2026.
Round-trip from | $778 (Kiwi.com) |
|---|---|
One-way from | $333 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 9/17
6:20 pm-8:00 am
1 stop12h 40m
Santiago Arturo Merino Benitez
Thu 9/24
9:30 pm-6:08 pm
1 stop21h 38m
$905
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 1/17
7:47 pm-8:18 pm
2 stops22h 31m
Santiago Arturo Merino Benitez
Wed 1/27
5:13 am-9:44 am
2 stops30h 31m
$908
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 11/15
6:00 am-5:46 am
2 stops21h 46m
Santiago Arturo Merino Benitez
Tue 11/24
1:22 am-10:02 am
2 stops34h 40m
$908
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 1/17
7:05 pm-7:40 am
1 stop34h 35m
Santiago Arturo Merino Benitez
Sun 2/7
7:30 am-1:54 pm
2 stops32h 24m
$909
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Tue 9/15
6:40 am-5:40 am
2 stops22h 00m
Santiago Arturo Merino Benitez
Tue 9/22
8:55 pm-11:38 am
2 stops15h 43m
$915
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 11/3
6:30 am-8:50 am
2 stops24h 20m
Santiago Arturo Merino Benitez
Tue 11/10
10:45 pm-10:59 pm
2 stops26h 14m
$940
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Sat 10/31
7:43 pm-8:50 am
2 stops36h 07m
Santiago Arturo Merino Benitez
Wed 11/4
10:45 pm-4:28 pm
1 stop19h 43m
$970
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Sat 10/31
2:00 pm-7:40 am
1 stop16h 40m
Santiago Arturo Merino Benitez
Wed 11/4
11:10 pm-5:59 pm
1 stop20h 49m
$995
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
Wed 12/2
12:45 pm-6:55 am
2 stops16h 10m
Santiago Arturo Merino Benitez
Tue 12/22
8:30 am-11:18 am
3 stops28h 48m
$1,008
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 11/7
1:33 pm-4:55 am
2 stops37h 22m
Santiago Arturo Merino Benitez
Sun 11/15
11:55 pm-7:16 pm
1 stop21h 21m
$1,018
Showing 1-10 of 45 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
MYR-SCL
CHS-SCL
SAV-SCL
GSP-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
MYR-SCL
CHS-SCL
SAV-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on August 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 4, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |