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$262+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This KAYAK deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:33 amCLT - SCL
2 stops22h 27mLATAM Airlines
Thu 12/2511:10 pmSCL - CLT
1 stop13h 43mLATAM Airlines
Deal found 12/1$719
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:00 amSAV - SCL
3 stops28h 20mMultiple Airlines
Wed 2/411:24 amSCL - SAV
2 stops31h 49mMultiple Airlines
Deal found 12/2$727
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:57 pmCLT - SCL
2 stops23h 23mMultiple Airlines
Mon 12/810:35 amSCL - CLT
1 stop28h 06mMultiple Airlines
Deal found 12/2$788
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:57 pmCLT - SCL
2 stops16h 18mMultiple Airlines
Fri 12/126:00 amSCL - CLT
2 stops19h 59mMultiple Airlines
Deal found 12/4$800
This Delta deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1112:30 pmSAV - SCL
2 stops16h 30mDelta
Wed 2/411:30 pmSCL - SAV
1 stop19h 16mDelta
Deal found 12/2$818
This Delta deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:38 amCLT - SCL
1 stop18h 02mDelta
Thu 12/2511:10 pmSCL - CLT
1 stop18h 15mDelta
Deal found 12/1$875
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:38 pmCHS - SCL
2 stops38h 12mUnited Airlines
Wed 12/1710:45 pmSCL - CHS
1 stop19h 25mUnited Airlines
Deal found 12/3$918
This Mytrip deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:57 pmCLT - SCL
2 stops23h 23mMultiple Airlines
Thu 12/257:53 pmSCL - CLT
2 stops15h 46mMultiple Airlines
Deal found 12/1$964
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:55 pmCLT - SCL
3 stops45h 49mMultiple Airlines
Wed 12/313:52 pmSCL - CLT
3 stops19h 47mMultiple Airlines
Deal found 12/2$965
This LATAM Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:00 pmCHS - SCL
2 stops20h 30mLATAM Airlines
Wed 12/179:30 pmSCL - CHS
1 stop16h 15mLATAM Airlines
Deal found 12/2$974
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:05 amCLT - SCL
2 stops20h 30mDelta
Wed 12/316:30 pmSCL - CLT
2 stops18h 23mDelta
Deal found 12/3$989
This LATAM Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/82:40 pmMYR - SCL
1 stop15h 00mLATAM Airlines
Thu 12/118:10 amSCL - MYR
2 stops17h 33mLATAM Airlines
Deal found 12/2$1,304

Find flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated December 4, 2025.

Round-trip from

$593
(Mytrip)

One-way from

$262
(Mytrip)
From South Carolina to Santiago Arturo Merino Benitez
Search Deals
One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Thu 1/22

3:15 pm-10:15 pm

3 stops29h 00m

Santiago Arturo Merino Benitez

Mon 1/26

12:35 pm-10:55 am

2 stops24h 20m

$696

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 3/2

2:10 pm-6:55 am

1 stop14h 45m

Santiago Arturo Merino Benitez

Mon 3/16

4:35 am-11:50 pm

2 stops20h 15m

$699

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

5:18 pm-3:30 pm

2 stops20h 12m

Santiago Arturo Merino Benitez

Thu 2/5

6:30 pm-9:26 am

2 stops16h 56m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

7:32 am-8:15 am

1 stop22h 43m

Santiago Arturo Merino Benitez

Thu 2/5

10:30 pm-2:25 pm

1 stop17h 55m

$704

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Fri 1/30

7:00 am-2:40 pm

2 stops29h 40m

Santiago Arturo Merino Benitez

Sat 2/7

11:24 am-5:13 pm

2 stops31h 49m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 2/20

7:00 pm-3:30 pm

2 stops18h 30m

Santiago Arturo Merino Benitez

Tue 3/3

8:50 am-11:56 pm

2 stops17h 06m

$704

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Thu 1/22

6:00 am-6:55 am

1 stop22h 55m

Santiago Arturo Merino Benitez

Mon 1/26

6:30 pm-10:50 am

2 stops18h 20m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/23

7:00 am-10:39 am

2 stops25h 39m

Santiago Arturo Merino Benitez

Sun 3/8

1:35 am-12:22 pm

3 stops35h 47m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/23

6:59 pm-3:30 pm

2 stops18h 31m

Santiago Arturo Merino Benitez

Mon 3/9

6:30 pm-4:24 pm

2 stops22h 54m

$714

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Mon 3/9

6:58 pm-2:05 pm

2 stops18h 07m

Santiago Arturo Merino Benitez

Mon 3/16

5:15 am-11:59 pm

2 stops19h 44m

$714

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 42 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

One of the essential ways to save on airfare from South Carolina to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.

How much does it cost to fly round-trip from South Carolina to Santiago?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 14h 45m. LATAM Airlines provides one of the quickest options available for as low as $699. The distance between South Carolina and Santiago is about 4783 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Myrtle Beach Intl - Santiago Arturo Merino Benitez and Charleston - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$571Average$1,002FlexibilityNo cancel feeOn-time81%
DeltaCheapest$793Average$948FlexibilityNo cancel feeOn-timeN/A

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