$274+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jul 22 — Jul 291
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 22, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 22, 2026.
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:05 pm
CLT
- SCL
2 stops18h 00m
Delta
Wed 10/2811:10 pm
SCL
- CLT
1 stop17h 54m
Delta
Deal found 6/21![Delta logo]()
$613
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:50 am
CLT
- SCL
2 stops19h 05m
Delta
Mon 8/3111:00 pm
SCL
- CLT
2 stops19h 42m
Delta
Deal found 6/20![Delta logo]()
$618
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:00 am
CLT
- SCL
1 stop22h 15m
Delta
Tue 9/88:40 pm
SCL
- CLT
1 stop17h 50m
Delta
Deal found 6/20![Delta logo]()
$824
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:24 pm
CLT
- SCL
2 stops17h 36m
Multiple Airlines
Tue 8/411:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$833
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:59 pm
CLT
- SCL
2 stops31h 01m
Multiple Airlines
Mon 8/311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$850
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
1 stop12h 47m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/19![Delta logo]()
$855
This LATAM Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:45 am
CLT
- SCL
3 stops24h 40m
LATAM Airlines
Wed 10/287:40 am
SCL
- CLT
2 stops17h 13m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$859
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/131:00 pm
CHS
- SCL
2 stops18h 00m
American Airlines
Thu 7/239:00 pm
SCL
- CHS
2 stops18h 16m
American Airlines
Deal found 6/19![American Airlines logo]()
$860
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:24 pm
CLT
- SCL
2 stops38h 36m
Multiple Airlines
Mon 8/311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$864
This oojo deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
3 stops27h 17m
LATAM Airlines
Thu 7/237:25 am
SCL
- CHS
2 stops15h 54m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$865
This Orbitz deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Wed 10/2812:10 am
SCL
- CLT
1 stop11h 54m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$875
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:54 pm
CLT
- SCL
1 stop11h 21m
Delta
Thu 8/1310:55 pm
SCL
- CLT
1 stop24h 03m
Delta
Deal found 6/20![Delta logo]()
$878
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 22, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 22, 2026.
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:05 pm
CLT
- SCL
2 stops17h 00m
Delta
Fri 11/1311:25 pm
SCL
- CLT
2 stops20h 47m
Delta
Deal found 6/17![Delta logo]()
$613
This LATAM Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:15 pm
CHS
- SCL
2 stops23h 50m
LATAM Airlines
Mon 12/711:10 pm
SCL
- CHS
1 stop12h 32m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$855
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:56 pm
GSP
- SCL
1 stop15h 04m
American Airlines
Sat 11/710:15 pm
SCL
- GSP
1 stop13h 37m
American Airlines
Deal found 6/17![American Airlines logo]()
$915
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:23 pm
GSP
- SCL
2 stops16h 27m
United Airlines
Sat 11/710:45 pm
SCL
- GSP
1 stop18h 33m
United Airlines
Deal found 6/17![United Airlines logo]()
$915
This Ovago deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:40 pm
SAV
- SCL
2 stops31h 03m
Copa Airlines
Sun 8/911:22 am
SCL
- SAV
2 stops31h 00m
Copa Airlines
Deal found 6/17![Copa Airlines logo]()
$1,175
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:15 pm
CLT
- SCL
1 stop16h 10m
Delta
Wed 10/2811:10 pm
SCL
- CLT
1 stop22h 08m
Delta
Deal found 6/21![Delta logo]()
$613
This Ovago deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/410:56 am
SAV
- SCL
1 stop19h 29m
Multiple Airlines
Tue 8/1110:55 pm
SCL
- SAV
1 stop19h 25m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$1,313
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:50 am
CLT
- SCL
2 stops19h 05m
Delta
Mon 8/3111:00 pm
SCL
- CLT
2 stops19h 42m
Delta
Deal found 6/20![Delta logo]()
$618
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:00 pm
CLT
- SCL
2 stops17h 55m
Delta
Wed 9/308:40 pm
SCL
- CLT
1 stop20h 31m
Delta
Deal found 6/21![Delta logo]()
$618
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:07 am
CLT
- SCL
2 stops19h 48m
Delta
Sun 10/1810:55 pm
SCL
- CLT
1 stop15h 59m
Delta
Deal found 6/21![Delta logo]()
$618
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:25 am
CHS
- SCL
3 stops23h 24m
LATAM Airlines
Sun 8/3011:05 pm
SCL
- CHS
2 stops18h 46m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$855
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:02 am
CLT
- SCL
1 stop24h 23m
Delta
Wed 9/211:00 pm
SCL
- CLT
2 stops17h 12m
Delta
Deal found 6/21![Delta logo]()
$618
This LATAM Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
2 stops26h 27m
LATAM Airlines
Thu 7/235:40 am
SCL
- CHS
2 stops17h 39m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$855
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:15 am
MYR
- SCL
2 stops20h 50m
American Airlines
Wed 8/268:50 pm
SCL
- MYR
2 stops22h 01m
American Airlines
Deal found 6/17![American Airlines logo]()
$952
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:25 am
MYR
- SCL
2 stops19h 25m
United Airlines
Sun 12/610:45 pm
SCL
- MYR
2 stops37h 52m
United Airlines
Deal found 6/19![United Airlines logo]()
$1,001
This LATAM Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:42 pm
GSP
- SCL
3 stops19h 48m
LATAM Airlines
Sun 12/2011:25 pm
SCL
- GSP
2 stops21h 24m
LATAM Airlines
Deal found 6/19![LATAM Airlines logo]()
$920
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/187:08 pm
GSP
- SCL
2 stops55h 52m
United Airlines
Fri 7/2412:06 am
SCL
- GSP
2 stops34h 31m
United Airlines
Deal found 6/20![United Airlines logo]()
$1,137
This LATAM Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:16 pm
GSP
- SCL
3 stops20h 09m
LATAM Airlines
Mon 7/136:00 pm
SCL
- GSP
3 stops25h 10m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$950
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:30 am
GSP
- SCL
2 stops40h 56m
United Airlines
Fri 7/314:21 am
SCL
- GSP
2 stops30h 16m
United Airlines
Deal found 6/18![United Airlines logo]()
$1,137
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
1 stop12h 47m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/21![Delta logo]()
$855
This oojo deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:45 am
GSP
- SCL
2 stops22h 05m
LATAM Airlines
Sat 11/78:40 am
SCL
- GSP
3 stops28h 18m
LATAM Airlines
Deal found 6/17![LATAM Airlines logo]()
$952
This LATAM Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:15 pm
MYR
- SCL
1 stop15h 25m
LATAM Airlines
Sun 12/611:25 pm
SCL
- MYR
2 stops26h 10m
LATAM Airlines
Deal found 6/19![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:03 am
GSP
- SCL
2 stops19h 32m
Delta
Mon 7/1311:00 pm
SCL
- GSP
2 stops21h 15m
Delta
Deal found 6/20![Delta logo]()
$950
This LATAM Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:18 pm
MYR
- SCL
1 stop16h 57m
LATAM Airlines
Wed 8/264:10 am
SCL
- MYR
2 stops19h 20m
LATAM Airlines
Deal found 6/17![LATAM Airlines logo]()
$1,027
This LATAM Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:02 pm
MYR
- SCL
2 stops19h 03m
LATAM Airlines
Tue 8/254:30 pm
SCL
- MYR
2 stops25h 37m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$1,057
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:47 pm
SAV
- SCL
2 stops17h 13m
Delta
Tue 8/1110:55 pm
SCL
- SAV
1 stop18h 16m
Delta
Deal found 6/20![Delta logo]()
$1,120
This Expedia deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:37 pm
SAV
- SCL
2 stops35h 08m
LATAM Airlines
Tue 8/115:40 am
SCL
- SAV
2 stops18h 41m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$1,078
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:42 pm
GSP
- SCL
1 stop13h 58m
Delta
Sun 12/206:45 pm
SCL
- GSP
2 stops16h 46m
Delta
Deal found 6/19![Delta logo]()
$1,120
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:44 pm
GSP
- SCL
1 stop11h 31m
Delta
Tue 11/2411:25 pm
SCL
- GSP
2 stops22h 49m
Delta
Deal found 6/18![Delta logo]()
$1,132
This LATAM Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:47 pm
SAV
- SCL
3 stops22h 02m
LATAM Airlines
Thu 8/278:40 pm
SCL
- SAV
1 stop22h 14m
LATAM Airlines
Deal found 6/18![LATAM Airlines logo]()
$1,315
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated June 22, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated June 22, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:44 am
GSP
- SCL
2 stops18h 16m
LATAM Airlines
Fri 7/104:10 am
SCL
- GSP
2 stops19h 44m
LATAM Airlines
Deal found 6/17![LATAM Airlines logo]()
$975
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:03 am
GSP
- SCL
2 stops19h 32m
Delta
Mon 7/1311:00 pm
SCL
- GSP
2 stops21h 15m
Delta
Deal found 6/20![Delta logo]()
$950
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:40 pm
GSP
- SCL
1 stop11h 20m
American Airlines
Mon 7/139:00 pm
SCL
- GSP
2 stops22h 03m
American Airlines
Deal found 6/20![American Airlines logo]()
$1,049
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:59 pm
CLT
- SCL
2 stops31h 01m
Multiple Airlines
Mon 8/311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$850
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:24 pm
CLT
- SCL
2 stops17h 36m
Multiple Airlines
Tue 8/411:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$833
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
1 stop12h 47m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/19![Delta logo]()
$855
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/131:00 pm
CHS
- SCL
2 stops18h 00m
American Airlines
Thu 7/239:00 pm
SCL
- CHS
2 stops18h 16m
American Airlines
Deal found 6/19![American Airlines logo]()
$860
This oojo deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
3 stops27h 17m
LATAM Airlines
Thu 7/237:25 am
SCL
- CHS
2 stops15h 54m
LATAM Airlines
Deal found 6/20![LATAM Airlines logo]()
$865
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:24 pm
CLT
- SCL
2 stops18h 51m
Multiple Airlines
Wed 7/2911:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$984
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1910:59 pm
CLT
- SCL
2 stops26h 51m
Multiple Airlines
Thu 7/2311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$944
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:24 pm
CLT
- SCL
2 stops38h 36m
Multiple Airlines
Mon 8/311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$864
This Expedia deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:44 pm
GSP
- SCL
2 stops41h 51m
LATAM Airlines
Fri 7/318:40 am
SCL
- GSP
3 stops34h 15m
LATAM Airlines
Deal found 6/18![LATAM Airlines logo]()
$1,017
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 22, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:53 pm
CHS
- SCL
2 stops35h 27m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:45 pm
GSP
- SCL
2 stops29h 05m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:07 am
GSP
- SCL
2 stops14h 43m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:59 pm
CLT
- SCL
2 stops38h 36m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:56 am
CLT
- SCL
2 stops20h 18m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:40 pm
GSP
- SCL
2 stops35h 20m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/268:28 pm
GSP
- SCL
2 stops33h 32m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:59 pm
CLT
- SCL
2 stops31h 01m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:23 pm
CHS
- SCL
2 stops31h 20m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:35 am
GSP
- SCL
3 stops39h 45m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$481
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:44 pm
CLT
- SCL
3 stops41h 01m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$484
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated June 22, 2026.
Round-trip from | $613 (Delta) |
|---|---|
One-way from | $274 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 11/9
7:05 pm-2:05 pm
2 stops17h 00m
Santiago Arturo Merino Benitez
Fri 11/13
11:25 pm-6:12 pm
2 stops20h 47m
$613
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 10/21
1:15 pm-6:25 am
1 stop16h 10m
Santiago Arturo Merino Benitez
Wed 10/28
11:10 pm-8:18 pm
1 stop22h 08m
$613
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 8/24
11:50 am-6:55 am
2 stops19h 05m
Santiago Arturo Merino Benitez
Mon 8/31
11:00 pm-6:42 pm
2 stops19h 42m
$618
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 9/16
12:00 pm-6:55 am
2 stops17h 55m
Santiago Arturo Merino Benitez
Wed 9/30
8:40 pm-4:11 pm
1 stop20h 31m
$618
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 10/14
10:07 am-6:55 am
2 stops19h 48m
Santiago Arturo Merino Benitez
Sun 10/18
10:55 pm-1:54 pm
1 stop15h 59m
$618
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 8/26
6:02 am-6:25 am
1 stop24h 23m
Santiago Arturo Merino Benitez
Wed 9/2
11:00 pm-4:12 pm
2 stops17h 12m
$618
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 12/3
12:15 pm-2:05 pm
2 stops23h 50m
Santiago Arturo Merino Benitez
Mon 12/7
11:10 pm-9:42 am
1 stop12h 32m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 8/26
11:25 am-10:49 am
3 stops23h 24m
Santiago Arturo Merino Benitez
Sun 8/30
11:05 pm-5:51 pm
2 stops18h 46m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
6:28 pm-8:55 pm
2 stops26h 27m
Santiago Arturo Merino Benitez
Thu 7/23
5:40 am-11:19 pm
2 stops17h 39m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
6:28 pm-7:15 am
1 stop12h 47m
Santiago Arturo Merino Benitez
Thu 7/23
8:40 pm-6:54 pm
1 stop22h 14m
$855
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on June 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 22, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |