$286+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Mar 24 — Mar 311
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:42 am
CLT
- SCL
2 stops50h 58m
Multiple Airlines
Wed 4/110:30 am
SCL
- CLT
1 stop14h 55m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:44 pm
CLT
- SCL
2 stops31h 46m
Multiple Airlines
Wed 4/2210:30 am
SCL
- CLT
1 stop33h 58m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$577
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:29 pm
CLT
- SCL
2 stops32h 01m
Multiple Airlines
Mon 4/1311:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$578
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:34 pm
CLT
- SCL
2 stops23h 31m
Multiple Airlines
Wed 4/1510:30 am
SCL
- CLT
1 stop27h 08m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$613
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:15 am
CLT
- SCL
2 stops23h 15m
Multiple Airlines
Wed 4/1511:00 pm
SCL
- CLT
1 stop14h 38m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$616
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
CLT
- SCL
2 stops30h 30m
Multiple Airlines
Tue 4/146:40 am
SCL
- CLT
3 stops29h 19m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$634
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:00 am
CLT
- SCL
2 stops38h 15m
Multiple Airlines
Sun 4/511:00 pm
SCL
- CLT
1 stop25h 25m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$635
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:07 am
CHS
- SCL
2 stops25h 32m
Multiple Airlines
Mon 3/308:33 pm
SCL
- CHS
3 stops26h 40m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$751
This LATAM Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:09 pm
CHS
- SCL
1 stop13h 06m
LATAM Airlines
Mon 4/134:50 pm
SCL
- CHS
2 stops18h 30m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$783
This LATAM Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:57 pm
CHS
- SCL
2 stops23h 28m
LATAM Airlines
Sun 5/34:30 pm
SCL
- CHS
2 stops26h 08m
LATAM Airlines
Deal found 2/21![LATAM Airlines logo]()
$797
This Gurufare deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:59 pm
CHS
- SCL
2 stops33h 36m
LATAM Airlines
Wed 5/138:40 pm
SCL
- CHS
1 stop13h 00m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$802
This LATAM Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:30 am
GSP
- SCL
2 stops21h 05m
LATAM Airlines
Tue 4/145:40 am
SCL
- GSP
2 stops18h 16m
LATAM Airlines
Deal found 2/20![LATAM Airlines logo]()
$807
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:44 pm
CLT
- SCL
2 stops31h 46m
Multiple Airlines
Wed 4/2210:30 am
SCL
- CLT
1 stop33h 58m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$577
This KAYAK deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:30 pm
CLT
- SCL
2 stops24h 55m
LATAM Airlines
Thu 7/2310:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:07 am
CLT
- SCL
2 stops19h 53m
Delta
Tue 7/218:40 pm
SCL
- CLT
1 stop19h 26m
Delta
Deal found 2/18![Delta logo]()
$775
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:14 am
MYR
- SCL
2 stops20h 46m
American Airlines
Tue 4/78:35 pm
SCL
- MYR
2 stops21h 25m
American Airlines
Deal found 2/19![American Airlines logo]()
$901
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:00 am
CLT
- SCL
1 stop22h 00m
Multiple Airlines
Tue 3/177:15 am
SCL
- CLT
2 stops27h 32m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$760
This KAYAK deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:30 pm
CLT
- SCL
2 stops24h 55m
LATAM Airlines
Wed 7/228:40 pm
SCL
- CLT
1 stop14h 24m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:07 am
CLT
- SCL
2 stops19h 53m
Delta
Sun 7/2610:55 pm
SCL
- CLT
1 stop23h 28m
Delta
Deal found 2/18![Delta logo]()
$815
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
- SCL
2 stops29h 30m
Multiple Airlines
Tue 3/177:15 am
SCL
- CLT
2 stops27h 32m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$760
This KAYAK deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/232:26 pm
CHS
- SCL
1 stop16h 14m
LATAM Airlines
Mon 3/307:45 pm
SCL
- CHS
2 stops16h 39m
LATAM Airlines
Deal found 2/21![LATAM Airlines logo]()
$783
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:30 am
CLT
- SCL
2 stops14h 15m
Delta
Sat 7/2510:55 pm
SCL
- CLT
2 stops19h 19m
Delta
Deal found 2/18![Delta logo]()
$820
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
- SCL
2 stops29h 30m
Multiple Airlines
Mon 3/167:15 am
SCL
- CLT
2 stops29h 52m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$762
This Gurufare deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:09 pm
CHS
- SCL
1 stop13h 06m
LATAM Airlines
Mon 4/1310:55 pm
SCL
- CHS
1 stop18h 11m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$783
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:30 am
CLT
- SCL
2 stops14h 15m
Delta
Sun 7/2610:55 pm
SCL
- CLT
1 stop19h 23m
Delta
Deal found 2/18![Delta logo]()
$820
This LATAM Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:57 pm
CHS
- SCL
2 stops20h 08m
LATAM Airlines
Sun 5/311:05 pm
SCL
- CHS
2 stops25h 17m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$797
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:45 am
CLT
- SCL
2 stops18h 15m
Delta
Sat 7/2511:00 pm
SCL
- CLT
2 stops19h 44m
Delta
Deal found 2/18![Delta logo]()
$820
This Gurufare deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:59 pm
CHS
- SCL
2 stops33h 36m
LATAM Airlines
Wed 5/138:40 pm
SCL
- CHS
1 stop13h 00m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$802
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/12:34 pm
GSP
- SCL
1 stop16h 41m
Delta
Wed 4/158:40 pm
SCL
- GSP
1 stop12h 29m
Delta
Deal found 2/21![Delta logo]()
$820
This LATAM Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:30 am
GSP
- SCL
2 stops21h 05m
LATAM Airlines
Tue 4/145:40 am
SCL
- GSP
2 stops18h 16m
LATAM Airlines
Deal found 2/20![LATAM Airlines logo]()
$807
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:09 am
MYR
- SCL
3 stops25h 06m
Multiple Airlines
Tue 4/73:20 pm
SCL
- MYR
2 stops26h 13m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$994
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:59 pm
GSP
- SCL
1 stop11h 16m
Delta
Wed 4/158:40 pm
SCL
- GSP
1 stop15h 41m
Delta
Deal found 2/21![Delta logo]()
$860
This FlightHub deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:45 am
GSP
- SCL
2 stops22h 50m
LATAM Airlines
Wed 4/1511:00 pm
SCL
- GSP
2 stops19h 55m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$810
This KAYAK deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:30 pm
CLT
- SCL
2 stops24h 55m
LATAM Airlines
Sat 7/2510:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$815
This FlightHub deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:41 pm
GSP
- SCL
1 stop12h 59m
LATAM Airlines
Mon 3/3012:25 am
SCL
- GSP
2 stops20h 12m
LATAM Airlines
Deal found 2/22![LATAM Airlines logo]()
$820
This KAYAK deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/312:29 pm
CHS
- SCL
2 stops25h 06m
LATAM Airlines
Mon 4/137:45 pm
SCL
- CHS
2 stops15h 35m
LATAM Airlines
Deal found 2/20![LATAM Airlines logo]()
$823
This KAYAK deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2211:56 am
GSP
- SCL
2 stops15h 34m
LATAM Airlines
Sun 3/298:55 pm
SCL
- GSP
2 stops22h 59m
LATAM Airlines
Deal found 2/20![LATAM Airlines logo]()
$860
This FlightHub deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:59 pm
GSP
- SCL
1 stop11h 16m
LATAM Airlines
Wed 4/157:15 am
SCL
- GSP
2 stops16h 41m
LATAM Airlines
Deal found 2/21![LATAM Airlines logo]()
$860
This KAYAK deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:54 pm
MYR
- SCL
1 stop11h 46m
LATAM Airlines
Tue 4/78:40 pm
SCL
- MYR
1 stop12h 53m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$903
This LATAM Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:00 pm
GSP
- SCL
1 stop19h 15m
LATAM Airlines
Thu 8/137:45 am
SCL
- GSP
2 stops15h 53m
LATAM Airlines
Deal found 2/18![LATAM Airlines logo]()
$1,095
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated February 22, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated February 22, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:00 am
CLT
- SCL
3 stops38h 50m
Multiple Airlines
Fri 2/2712:35 pm
SCL
- CLT
2 stops25h 45m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$797
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
- SCL
2 stops29h 30m
Multiple Airlines
Tue 3/177:15 am
SCL
- CLT
2 stops27h 32m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$760
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
- SCL
2 stops29h 30m
Multiple Airlines
Mon 3/167:15 am
SCL
- CLT
2 stops29h 52m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$762
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/79:23 pm
CLT
- SCL
2 stops32h 17m
Multiple Airlines
Sun 3/1510:30 am
SCL
- CLT
1 stop24h 42m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$792
This eDestinos deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:28 pm
CLT
- SCL
2 stops46h 17m
Multiple Airlines
Wed 3/259:05 pm
SCL
- CLT
2 stops38h 07m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$680
This KAYAK deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2211:56 am
GSP
- SCL
2 stops15h 34m
LATAM Airlines
Sun 3/298:55 pm
SCL
- GSP
2 stops22h 59m
LATAM Airlines
Deal found 2/20![LATAM Airlines logo]()
$860
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:07 am
CHS
- SCL
2 stops25h 32m
Multiple Airlines
Mon 3/308:33 pm
SCL
- CHS
3 stops26h 40m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$751
This KAYAK deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:51 pm
CHS
- SCL
2 stops21h 39m
LATAM Airlines
Mon 3/307:45 pm
SCL
- CHS
2 stops16h 39m
LATAM Airlines
Deal found 2/21![LATAM Airlines logo]()
$783
This FlightHub deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:41 pm
GSP
- SCL
2 stops19h 24m
LATAM Airlines
Tue 3/315:10 am
SCL
- GSP
2 stops19h 44m
LATAM Airlines
Deal found 2/22![LATAM Airlines logo]()
$813
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:26 pm
GSP
- SCL
1 stop12h 39m
American Airlines
Tue 3/319:25 pm
SCL
- GSP
1 stop22h 31m
American Airlines
Deal found 2/22![American Airlines logo]()
$820
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:42 am
CLT
- SCL
2 stops50h 58m
Multiple Airlines
Wed 4/110:30 am
SCL
- CLT
1 stop14h 55m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:00 am
CLT
- SCL
2 stops38h 15m
Multiple Airlines
Sun 4/511:00 pm
SCL
- CLT
1 stop25h 25m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$635
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:09 pm
CLT
- SCL
3 stops38h 21m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1410:52 am
CLT
- SCL
3 stops48h 08m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:57 am
CLT
- SCL
1 stop22h 08m
American Airlines
Deal found 2/18![American Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/292:28 pm
MYR
- SCL
3 stops47h 07m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$438
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/143:25 pm
CLT
- SCL
1 stop13h 30m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$455
This eDestinos deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:50 pm
MYR
- SCL
1 stop11h 25m
LATAM Airlines
Deal found 2/19![LATAM Airlines logo]()
$579
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated February 22, 2026.
Round-trip from | $577 (Kiwi.com) |
|---|---|
One-way from | $286 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
South Carolina
Fly to
Santiago
Route
Depart
Return
Price
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 4/13
9:44 pm-5:30 am
2 stops31h 46m
Santiago Arturo Merino Benitez
Wed 4/22
10:30 am-8:28 pm
1 stop33h 58m
$577
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 3/5
7:00 am-7:00 am
1 stop22h 00m
Santiago Arturo Merino Benitez
Tue 3/17
7:15 am-9:47 am
2 stops27h 32m
$760
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/4
7:00 am-2:30 pm
2 stops29h 30m
Santiago Arturo Merino Benitez
Tue 3/17
7:15 am-9:47 am
2 stops27h 32m
$760
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/4
7:00 am-2:30 pm
2 stops29h 30m
Santiago Arturo Merino Benitez
Mon 3/16
7:15 am-12:07 pm
2 stops29h 52m
$762
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/14
4:30 pm-5:25 pm
2 stops24h 55m
Santiago Arturo Merino Benitez
Thu 7/23
10:55 pm-1:52 pm
1 stop14h 57m
$775
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/14
10:07 am-6:00 am
2 stops19h 53m
Santiago Arturo Merino Benitez
Tue 7/21
8:40 pm-4:06 pm
1 stop19h 26m
$775
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/14
4:30 pm-5:25 pm
2 stops24h 55m
Santiago Arturo Merino Benitez
Wed 7/22
8:40 pm-11:04 am
1 stop14h 24m
$775
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 3/23
2:26 pm-7:40 am
1 stop16h 14m
Santiago Arturo Merino Benitez
Mon 3/30
7:45 pm-11:24 am
2 stops16h 39m
$783
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 4/6
6:09 pm-7:15 am
1 stop13h 06m
Santiago Arturo Merino Benitez
Mon 4/13
10:55 pm-5:06 pm
1 stop18h 11m
$783
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 4/29
5:57 pm-2:05 pm
2 stops20h 08m
Santiago Arturo Merino Benitez
Sun 5/3
11:05 pm-12:22 am
2 stops25h 17m
$797
Showing 1-10 of 34 results
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
MYR-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on February 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 22, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$532 | Average$888 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$562 | Average$901 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$845 | FlexibilityNo cancel fee | On-time71% |