$330+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jul 16 — Jul 231
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/89:00 am
CLT
- SCL
2 stops21h 00m
Delta
Wed 8/128:40 pm
SCL
- CLT
1 stop21h 38m
Delta
Deal found 6/15![Delta logo]()
$653
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:56 pm
CLT
- SCL
2 stops20h 29m
Multiple Airlines
Mon 8/245:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$779
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:15 pm
CLT
- SCL
1 stop11h 45m
American Airlines
Sun 11/810:15 pm
SCL
- CLT
1 stop21h 12m
American Airlines
Deal found 6/13![American Airlines logo]()
$854
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:41 am
CHS
- SCL
1 stop21h 34m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/16![Delta logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:23 am
CLT
- SCL
2 stops35h 13m
Copa Airlines
Sat 11/145:07 am
SCL
- CLT
2 stops30h 37m
Copa Airlines
Deal found 6/11![Copa Airlines logo]()
$858
This LATAM Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:25 am
CHS
- SCL
2 stops17h 15m
LATAM Airlines
Wed 8/1211:00 pm
SCL
- CHS
2 stops19h 52m
LATAM Airlines
Deal found 6/13![LATAM Airlines logo]()
$860
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:43 pm
CLT
- SCL
2 stops31h 31m
Multiple Airlines
Wed 8/1911:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$885
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:30 pm
CLT
- SCL
1 stop13h 10m
Delta
Sat 11/147:45 am
SCL
- CLT
2 stops18h 08m
Delta
Deal found 6/11![Delta logo]()
$899
This oojo deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
3 stops27h 17m
LATAM Airlines
Thu 7/238:40 pm
SCL
- CHS
1 stop15h 20m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$899
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:36 am
CLT
- SCL
1 stop20h 24m
American Airlines
Sun 11/1510:15 pm
SCL
- CLT
2 stops16h 08m
American Airlines
Deal found 6/11![American Airlines logo]()
$904
This Copa Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:23 am
CLT
- SCL
2 stops36h 56m
Copa Airlines
Sat 11/141:02 am
SCL
- CLT
2 stops34h 42m
Copa Airlines
Deal found 6/11![Copa Airlines logo]()
$905
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:43 pm
CLT
- SCL
2 stops28h 37m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$918
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:50 am
CLT
- SCL
1 stop19h 25m
Delta
Wed 8/128:40 pm
SCL
- CLT
1 stop21h 38m
Delta
Deal found 6/15![Delta logo]()
$653
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:56 pm
CLT
- SCL
1 stop13h 59m
Multiple Airlines
Mon 8/245:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$779
This LATAM Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:15 pm
CHS
- SCL
2 stops23h 50m
LATAM Airlines
Mon 12/711:10 pm
SCL
- CHS
1 stop12h 32m
LATAM Airlines
Deal found 6/12![LATAM Airlines logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:47 pm
CLT
- SCL
2 stops23h 32m
Copa Airlines
Sat 11/71:22 am
SCL
- CLT
2 stops34h 22m
Copa Airlines
Deal found 6/13![Copa Airlines logo]()
$858
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am
GSP
- SCL
2 stops24h 30m
United Airlines
Wed 10/289:45 pm
SCL
- GSP
1 stop18h 33m
United Airlines
Deal found 6/13![United Airlines logo]()
$920
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:41 am
CHS
- SCL
1 stop21h 34m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/13![Delta logo]()
$855
This LATAM Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:20 am
CHS
- SCL
2 stops22h 40m
LATAM Airlines
Wed 7/228:40 pm
SCL
- CHS
1 stop15h 20m
LATAM Airlines
Deal found 6/11![LATAM Airlines logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:23 am
CLT
- SCL
2 stops35h 56m
Copa Airlines
Thu 11/193:48 am
SCL
- CLT
2 stops31h 56m
Copa Airlines
Deal found 6/14![Copa Airlines logo]()
$858
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:43 pm
CLT
- SCL
2 stops31h 31m
Multiple Airlines
Wed 8/1911:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$885
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:50 pm
CLT
- SCL
2 stops59h 00m
United Airlines
Sat 10/3110:45 pm
SCL
- CLT
2 stops26h 49m
United Airlines
Deal found 6/13![United Airlines logo]()
$921
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:45 pm
CHS
- SCL
1 stop12h 30m
Delta
Wed 8/1210:55 pm
SCL
- CHS
1 stop17h 32m
Delta
Deal found 6/13![Delta logo]()
$855
This oojo deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
3 stops27h 17m
LATAM Airlines
Thu 7/238:40 pm
SCL
- CHS
1 stop15h 20m
LATAM Airlines
Deal found 6/15![LATAM Airlines logo]()
$899
This Copa Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:23 am
CLT
- SCL
2 stops36h 56m
Copa Airlines
Sat 11/141:02 am
SCL
- CLT
2 stops34h 42m
Copa Airlines
Deal found 6/11![Copa Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:59 pm
CLT
- SCL
2 stops17h 06m
Delta
Sat 11/147:45 am
SCL
- CLT
2 stops18h 08m
Delta
Deal found 6/11![Delta logo]()
$899
This Copa Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Sat 11/143:19 am
SCL
- CLT
2 stops32h 25m
Copa Airlines
Deal found 6/11![Copa Airlines logo]()
$905
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:50 pm
SAV
- SCL
2 stops62h 00m
United Airlines
Tue 12/810:45 pm
SCL
- SAV
1 stop16h 15m
United Airlines
Deal found 6/13![United Airlines logo]()
$1,000
This LATAM Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:44 pm
GSP
- SCL
1 stop11h 31m
LATAM Airlines
Sun 7/194:50 pm
SCL
- GSP
2 stops18h 07m
LATAM Airlines
Deal found 6/13![LATAM Airlines logo]()
$945
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:05 pm
CLT
- SCL
2 stops17h 00m
Delta
Fri 11/1311:10 pm
SCL
- CLT
1 stop18h 54m
Delta
Deal found 6/11![Delta logo]()
$899
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:25 pm
MYR
- SCL
2 stops37h 25m
United Airlines
Mon 12/710:45 pm
SCL
- MYR
2 stops37h 52m
United Airlines
Deal found 6/15![United Airlines logo]()
$1,022
This LATAM Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:00 pm
GSP
- SCL
1 stop18h 40m
LATAM Airlines
Wed 10/2811:10 pm
SCL
- GSP
1 stop12h 48m
LATAM Airlines
Deal found 6/12![LATAM Airlines logo]()
$945
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:07 am
CLT
- SCL
1 stop19h 33m
Delta
Sun 11/157:45 am
SCL
- CLT
2 stops18h 08m
Delta
Deal found 6/11![Delta logo]()
$899
This Expedia deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:05 pm
GSP
- SCL
3 stops18h 25m
LATAM Airlines
Fri 12/189:40 am
SCL
- GSP
3 stops29h 28m
LATAM Airlines
Deal found 6/14![LATAM Airlines logo]()
$981
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:44 pm
GSP
- SCL
1 stop11h 31m
Delta
Sun 7/198:40 pm
SCL
- GSP
1 stop15h 34m
Delta
Deal found 6/13![Delta logo]()
$975
This Expedia deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:44 pm
GSP
- SCL
2 stops41h 51m
LATAM Airlines
Fri 7/318:30 am
SCL
- GSP
3 stops27h 48m
LATAM Airlines
Deal found 6/14![LATAM Airlines logo]()
$1,017
This LATAM Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:55 am
MYR
- SCL
1 stop18h 45m
LATAM Airlines
Mon 12/79:50 pm
SCL
- MYR
1 stop14h 18m
LATAM Airlines
Deal found 6/13![LATAM Airlines logo]()
$1,027
This LATAM Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:02 pm
MYR
- SCL
1 stop12h 13m
LATAM Airlines
Wed 9/911:05 pm
SCL
- MYR
2 stops23h 37m
LATAM Airlines
Deal found 6/15![LATAM Airlines logo]()
$1,027
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:45 am
SAV
- SCL
2 stops36h 51m
United Airlines
Wed 8/2612:06 am
SCL
- SAV
2 stops21h 53m
United Airlines
Deal found 6/12![United Airlines logo]()
$1,504
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:44 pm
GSP
- SCL
1 stop11h 31m
Delta
Tue 11/2411:25 pm
SCL
- GSP
2 stops22h 49m
Delta
Deal found 6/15![Delta logo]()
$1,132
This Travelocity deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am
SAV
- SCL
1 stop22h 25m
LATAM Airlines
Tue 12/812:55 am
SCL
- SAV
1 stop18h 00m
LATAM Airlines
Deal found 6/13![LATAM Airlines logo]()
$1,375
This LATAM Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:47 pm
SAV
- SCL
3 stops22h 02m
LATAM Airlines
Thu 8/278:40 pm
SCL
- SAV
1 stop22h 14m
LATAM Airlines
Deal found 6/15![LATAM Airlines logo]()
$1,421
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated June 16, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated June 16, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2810:03 am
GSP
- SCL
2 stops19h 32m
Multiple Airlines
Tue 7/2810:30 am
SCL
- GSP
2 stops24h 27m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$950
This Expedia deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:16 pm
GSP
- SCL
3 stops52h 29m
LATAM Airlines
Tue 7/288:30 am
SCL
- GSP
3 stops26h 27m
LATAM Airlines
Deal found 6/14![LATAM Airlines logo]()
$965
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/212:29 pm
CLT
- SCL
2 stops25h 06m
Multiple Airlines
Sat 7/116:00 pm
SCL
- CLT
2 stops23h 12m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$1,035
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:28 pm
CLT
- SCL
2 stops26h 52m
Multiple Airlines
Tue 7/1412:40 am
SCL
- CLT
1 stop16h 32m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$1,002
This LATAM Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:44 pm
GSP
- SCL
1 stop11h 31m
LATAM Airlines
Sun 7/194:50 pm
SCL
- GSP
2 stops18h 07m
LATAM Airlines
Deal found 6/13![LATAM Airlines logo]()
$945
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:44 pm
GSP
- SCL
1 stop11h 31m
Delta
Sun 7/198:40 pm
SCL
- GSP
1 stop15h 34m
Delta
Deal found 6/13![Delta logo]()
$975
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:41 am
CHS
- SCL
1 stop21h 34m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/16![Delta logo]()
$855
This oojo deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
3 stops27h 17m
LATAM Airlines
Thu 7/238:40 pm
SCL
- CHS
1 stop15h 20m
LATAM Airlines
Deal found 6/16![LATAM Airlines logo]()
$899
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1710:59 pm
CLT
- SCL
2 stops48h 27m
Multiple Airlines
Wed 7/2911:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$1,027
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:00 pm
CLT
- SCL
1 stop13h 00m
American Airlines
Wed 7/299:00 pm
SCL
- CLT
1 stop18h 48m
American Airlines
Deal found 6/15![American Airlines logo]()
$1,124
This Expedia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:44 pm
GSP
- SCL
2 stops41h 51m
LATAM Airlines
Fri 7/318:40 pm
SCL
- GSP
1 stop22h 15m
LATAM Airlines
Deal found 6/12![LATAM Airlines logo]()
$1,008
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:44 pm
GSP
- SCL
1 stop11h 31m
Delta
Tue 11/2411:25 pm
SCL
- GSP
2 stops22h 49m
Delta
Deal found 6/15![Delta logo]()
$1,132
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:00 pm
CLT
- SCL
3 stops37h 20m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:02 pm
CLT
- SCL
2 stops29h 48m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:45 pm
GSP
- SCL
2 stops32h 29m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:48 pm
CLT
- SCL
3 stops42h 47m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:41 pm
CLT
- SCL
3 stops31h 09m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$459
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:43 am
CLT
- SCL
1 stop21h 32m
Delta
Deal found 6/15![Delta logo]()
$552
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:00 pm
GSP
- SCL
1 stop11h 00m
American Airlines
Deal found 6/12![American Airlines logo]()
$614
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated June 16, 2026.
Round-trip from | $653 (Delta) |
|---|---|
One-way from | $330 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 8/8
11:50 am-7:15 am
1 stop19h 25m
Santiago Arturo Merino Benitez
Wed 8/12
8:40 pm-6:18 pm
1 stop21h 38m
$653
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/18
4:56 pm-6:55 am
1 stop13h 59m
Santiago Arturo Merino Benitez
Mon 8/24
5:00 am-5:14 pm
2 stops36h 14m
$779
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 12/3
12:15 pm-2:05 pm
2 stops23h 50m
Santiago Arturo Merino Benitez
Mon 12/7
11:10 pm-9:42 am
1 stop12h 32m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
9:41 am-7:15 am
1 stop21h 34m
Santiago Arturo Merino Benitez
Thu 7/23
8:40 pm-6:54 pm
1 stop22h 14m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Tue 7/7
7:20 am-6:00 am
2 stops22h 40m
Santiago Arturo Merino Benitez
Wed 7/22
8:40 pm-12:00 pm
1 stop15h 20m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/6
6:45 pm-7:15 am
1 stop12h 30m
Santiago Arturo Merino Benitez
Wed 8/12
10:55 pm-4:27 pm
1 stop17h 32m
$855
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 10/27
7:47 pm-8:19 pm
2 stops23h 32m
Santiago Arturo Merino Benitez
Sat 11/7
1:22 am-9:44 am
2 stops34h 22m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 11/9
10:23 am-12:19 am
2 stops35h 56m
Santiago Arturo Merino Benitez
Thu 11/19
3:48 am-9:44 am
2 stops31h 56m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 8/5
9:43 pm-5:14 am
2 stops31h 31m
Santiago Arturo Merino Benitez
Wed 8/19
11:00 pm-5:14 pm
1 stop18h 14m
$885
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
6:28 pm-9:45 pm
3 stops27h 17m
Santiago Arturo Merino Benitez
Thu 7/23
8:40 pm-12:00 pm
1 stop15h 20m
$899
Showing 1-10 of 38 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
GSP-SCL
CHS-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
GSP-SCL
CHS-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on June 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 16, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |