$302+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Aug 18 — Aug 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
This Trip.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:56 am
CLT
- SCL
2 stops38h 24m
Multiple Airlines
Sat 9/191:30 am
SCL
- CLT
2 stops40h 08m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$680
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$792
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 am
CLT
- SCL
2 stops34h 36m
Multiple Airlines
Sun 9/2011:55 pm
SCL
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$793
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 am
CLT
- SCL
2 stops34h 36m
Multiple Airlines
Sat 9/1911:55 pm
SCL
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$794
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 am
CLT
- SCL
2 stops34h 36m
Multiple Airlines
Wed 9/1612:35 am
SCL
- CLT
1 stop16h 30m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$798
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:24 pm
CLT
- SCL
2 stops37h 26m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$805
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am
CLT
- SCL
2 stops18h 00m
Multiple Airlines
Sun 9/2011:55 pm
SCL
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$830
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:56 am
CLT
- SCL
2 stops16h 50m
Multiple Airlines
Sun 9/2011:55 pm
SCL
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$831
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am
CLT
- SCL
2 stops18h 00m
Multiple Airlines
Sat 9/1911:55 pm
SCL
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$832
This oojo deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:43 pm
CHS
- SCL
2 stops17h 12m
LATAM Airlines
Mon 9/289:30 am
SCL
- CHS
3 stops25h 36m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$893
This LATAM Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:59 pm
CHS
- SCL
2 stops18h 06m
LATAM Airlines
Mon 8/2411:05 pm
SCL
- CHS
2 stops19h 46m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$905
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:12 pm
CHS
- SCL
2 stops14h 48m
American Airlines
Mon 9/289:30 pm
SCL
- CHS
2 stops20h 20m
American Airlines
Deal found 7/15![American Airlines logo]()
$910
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
This Trip.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:56 am
CLT
- SCL
2 stops38h 24m
Multiple Airlines
Sat 9/191:30 am
SCL
- CLT
2 stops40h 08m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$680
This Copa Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/710:23 am
CLT
- SCL
2 stops39h 23m
Copa Airlines
Thu 1/2812:20 pm
SCL
- CLT
2 stops23h 24m
Copa Airlines
Deal found 7/16![Copa Airlines logo]()
$865
This LATAM Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:59 pm
CHS
- SCL
2 stops21h 26m
LATAM Airlines
Mon 8/246:45 pm
SCL
- CHS
2 stops17h 09m
LATAM Airlines
Deal found 7/16![LATAM Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:10 pm
CHS
- SCL
1 stop15h 05m
Delta
Mon 9/288:40 pm
SCL
- CHS
1 stop17h 25m
Delta
Deal found 7/15![Delta logo]()
$905
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
GSP
- SCL
2 stops24h 50m
United Airlines
Wed 11/410:45 pm
SCL
- GSP
1 stop19h 46m
United Airlines
Deal found 7/16![United Airlines logo]()
$970
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:49 pm
MYR
- SCL
2 stops18h 16m
American Airlines
Wed 9/99:30 pm
SCL
- MYR
2 stops20h 25m
American Airlines
Deal found 7/15![American Airlines logo]()
$1,002
This Copa Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/131:22 am
SCL
- CLT
2 stops34h 42m
Copa Airlines
Deal found 7/18![Copa Airlines logo]()
$902
This LATAM Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 pm
CHS
- SCL
2 stops22h 55m
LATAM Airlines
Sun 11/19:50 pm
SCL
- CHS
2 stops28h 09m
LATAM Airlines
Deal found 7/18![LATAM Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:10 am
GSP
- SCL
2 stops18h 50m
Delta
Mon 10/128:40 pm
SCL
- GSP
1 stop13h 45m
Delta
Deal found 7/17![Delta logo]()
$965
This Copa Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am
CLT
- SCL
2 stops17h 22m
Copa Airlines
Sun 11/11:22 am
SCL
- CLT
2 stops34h 42m
Copa Airlines
Deal found 7/18![Copa Airlines logo]()
$908
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:14 pm
MYR
- SCL
2 stops18h 51m
American Airlines
Wed 8/268:50 pm
SCL
- MYR
2 stops22h 01m
American Airlines
Deal found 7/16![American Airlines logo]()
$1,002
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:58 pm
CLT
- SCL
3 stops21h 07m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$1,025
This LATAM Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:25 am
CHS
- SCL
1 stop19h 50m
LATAM Airlines
Sat 9/128:40 pm
SCL
- CHS
1 stop22h 06m
LATAM Airlines
Deal found 7/16![LATAM Airlines logo]()
$935
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:28 pm
CLT
- SCL
2 stops37h 22m
United Airlines
Sun 12/2010:45 pm
SCL
- CLT
2 stops24h 10m
United Airlines
Deal found 7/18![United Airlines logo]()
$1,040
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:00 pm
GSP
- SCL
1 stop17h 15m
Delta
Tue 10/67:15 am
SCL
- GSP
2 stops17h 22m
Delta
Deal found 7/17![Delta logo]()
$965
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
SAV
- SCL
1 stop25h 05m
American Airlines
Wed 9/99:30 pm
SCL
- SAV
2 stops20h 12m
American Airlines
Deal found 7/19![American Airlines logo]()
$1,010
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:00 pm
GSP
- SCL
1 stop17h 15m
Delta
Thu 10/88:40 pm
SCL
- GSP
1 stop13h 45m
Delta
Deal found 7/17![Delta logo]()
$965
This LATAM Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:00 pm
GSP
- SCL
1 stop18h 40m
LATAM Airlines
Wed 11/411:10 pm
SCL
- GSP
1 stop13h 48m
LATAM Airlines
Deal found 7/16![LATAM Airlines logo]()
$995
This Copa Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:25 am
CLT
- SCL
2 stops36h 14m
Copa Airlines
Sat 9/191:06 am
SCL
- CLT
2 stops33h 38m
Copa Airlines
Deal found 7/15![Copa Airlines logo]()
$1,038
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:05 am
SAV
- SCL
2 stops16h 17m
United Airlines
Mon 9/73:14 am
SCL
- SAV
2 stops21h 08m
United Airlines
Deal found 7/18![United Airlines logo]()
$1,154
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:40 pm
GSP
- SCL
1 stop15h 35m
Delta
Thu 10/88:40 pm
SCL
- GSP
1 stop15h 18m
Delta
Deal found 7/17![Delta logo]()
$965
This Copa Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:25 am
CLT
- SCL
2 stops18h 45m
Copa Airlines
Tue 9/2912:22 pm
SCL
- CLT
2 stops46h 22m
Copa Airlines
Deal found 7/15![Copa Airlines logo]()
$1,040
This oojo deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:40 am
CLT
- SCL
1 stop19h 45m
LATAM Airlines
Tue 9/2911:55 pm
SCL
- CLT
1 stop14h 47m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$1,044
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:05 am
GSP
- SCL
2 stops20h 55m
Delta
Thu 10/88:40 pm
SCL
- GSP
1 stop13h 45m
Delta
Deal found 7/17![Delta logo]()
$965
This oojo deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:06 am
SAV
- SCL
2 stops22h 49m
LATAM Airlines
Tue 9/89:30 am
SCL
- SAV
3 stops27h 04m
LATAM Airlines
Deal found 7/18![LATAM Airlines logo]()
$1,076
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:25 pm
GSP
- SCL
1 stop12h 50m
Delta
Wed 10/78:40 pm
SCL
- GSP
1 stop13h 45m
Delta
Deal found 7/17![Delta logo]()
$995
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:00 am
SAV
- SCL
1 stop23h 50m
United Airlines
Thu 12/310:45 pm
SCL
- SAV
1 stop16h 15m
United Airlines
Deal found 7/15![United Airlines logo]()
$1,419
This LATAM Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:00 am
MYR
- SCL
2 stops31h 35m
LATAM Airlines
Wed 8/268:40 pm
SCL
- MYR
1 stop21h 27m
LATAM Airlines
Deal found 7/16![LATAM Airlines logo]()
$1,077
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:02 pm
MYR
- SCL
1 stop12h 13m
Delta
Wed 8/268:40 pm
SCL
- MYR
1 stop21h 27m
Delta
Deal found 7/16![Delta logo]()
$1,077
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:02 pm
MYR
- SCL
1 stop12h 13m
LATAM Airlines
Tue 9/812:05 am
SCL
- MYR
2 stops22h 37m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$1,077
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated July 19, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated July 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:59 pm
CLT
- SCL
2 stops31h 01m
Multiple Airlines
Fri 7/3111:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$984
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:24 pm
CLT
- SCL
2 stops17h 36m
Multiple Airlines
Mon 8/311:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$1,025
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/89:43 pm
CLT
- SCL
2 stops32h 12m
Multiple Airlines
Sat 8/1511:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$978
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:24 pm
CLT
- SCL
2 stops37h 26m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$805
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:24 pm
CLT
- SCL
2 stops16h 50m
Multiple Airlines
Sun 8/1610:25 am
SCL
- CLT
1 stop30h 47m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$1,029
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:14 pm
MYR
- SCL
2 stops18h 51m
American Airlines
Wed 8/268:50 pm
SCL
- MYR
2 stops22h 01m
American Airlines
Deal found 7/16![American Airlines logo]()
$1,002
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:43 pm
CLT
- SCL
2 stops31h 31m
Multiple Airlines
Sat 8/2211:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$928
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:43 pm
CLT
- SCL
2 stops28h 07m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$849
This LATAM Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:59 pm
CHS
- SCL
2 stops18h 06m
LATAM Airlines
Mon 8/2411:05 pm
SCL
- CHS
2 stops19h 46m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$905
This LATAM Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:25 am
CHS
- SCL
1 stop19h 50m
LATAM Airlines
Sat 9/128:40 pm
SCL
- CHS
1 stop22h 06m
LATAM Airlines
Deal found 7/16![LATAM Airlines logo]()
$935
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 9/611:55 pm
SCL
- CLT
1 stop17h 51m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$929
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$792
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:58 pm
MYR
- SCL
2 stops35h 58m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:38 pm
CLT
- SCL
3 stops37h 22m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:44 pm
CHS
- SCL
2 stops58h 06m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:11 pm
CLT
- SCL
2 stops30h 27m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:06 pm
MYR
- SCL
3 stops35h 29m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:48 pm
CLT
- SCL
3 stops58h 47m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:45 pm
GSP
- SCL
2 stops33h 10m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:28 pm
CLT
- SCL
3 stops55h 48m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:40 pm
MYR
- SCL
3 stops55h 42m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/121:59 pm
CLT
- SCL
2 stops38h 27m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:05 am
CHS
- SCL
3 stops42h 33m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:31 pm
CLT
- SCL
2 stops29h 04m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$421
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 19, 2026.
Round-trip from | $680 (Trip.com) |
|---|---|
One-way from | $302 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 9/6
8:56 am-12:20 am
2 stops38h 24m
Santiago Arturo Merino Benitez
Sat 9/19
1:30 am-4:38 pm
2 stops40h 08m
$680
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 1/7
10:23 am-3:46 am
2 stops39h 23m
Santiago Arturo Merino Benitez
Thu 1/28
12:20 pm-9:44 am
2 stops23h 24m
$865
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 11/6
6:00 am-11:36 pm
2 stops15h 36m
Santiago Arturo Merino Benitez
Fri 11/13
1:22 am-10:04 am
2 stops34h 42m
$902
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/20
7:59 pm-5:25 pm
2 stops21h 26m
Santiago Arturo Merino Benitez
Mon 8/24
6:45 pm-11:54 am
2 stops17h 09m
$905
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 9/16
4:10 pm-8:15 am
1 stop15h 05m
Santiago Arturo Merino Benitez
Mon 9/28
8:40 pm-1:05 pm
1 stop17h 25m
$905
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 10/28
5:35 pm-5:30 pm
2 stops22h 55m
Santiago Arturo Merino Benitez
Sun 11/1
9:50 pm-11:59 pm
2 stops28h 09m
$905
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 10/22
6:00 am-12:22 am
2 stops17h 22m
Santiago Arturo Merino Benitez
Sun 11/1
1:22 am-10:04 am
2 stops34h 42m
$908
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/20
11:25 am-7:15 am
1 stop19h 50m
Santiago Arturo Merino Benitez
Sat 9/12
8:40 pm-5:46 pm
1 stop22h 06m
$935
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Wed 9/30
10:10 am-6:00 am
2 stops18h 50m
Santiago Arturo Merino Benitez
Mon 10/12
8:40 pm-9:25 am
1 stop13h 45m
$965
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Wed 9/30
2:00 pm-8:15 am
1 stop17h 15m
Santiago Arturo Merino Benitez
Tue 10/6
7:15 am-11:37 pm
2 stops17h 22m
$965
Showing 1-10 of 57 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on July 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 19, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |