$354+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
May 26 — Jun 21
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This Mytrip deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:48 pm
CLT
- SCL
2 stops24h 42m
Multiple Airlines
Fri 6/53:20 pm
SCL
- CLT
2 stops28h 42m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$720
This Mytrip deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Mon 6/1512:30 am
SCL
- CLT
2 stops23h 10m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$727
This Mytrip deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:48 pm
CLT
- SCL
2 stops16h 42m
Multiple Airlines
Tue 6/23:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$754
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:34 pm
CLT
- SCL
2 stops18h 51m
Multiple Airlines
Tue 9/13:35 am
SCL
- CLT
2 stops37h 39m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$758
This eDestinos deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:58 pm
CLT
- SCL
3 stops34h 02m
Multiple Airlines
Mon 6/111:17 am
SCL
- CLT
2 stops29h 26m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$763
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Tue 5/193:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$776
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:33 pm
CLT
- SCL
1 stop35h 02m
Multiple Airlines
Tue 7/75:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$783
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:45 am
CLT
- SCL
1 stop23h 50m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$799
This LATAM Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:15 pm
CHS
- SCL
2 stops16h 45m
LATAM Airlines
Sat 10/246:00 pm
SCL
- CHS
2 stops18h 26m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:54 pm
GSP
- SCL
2 stops18h 11m
American Airlines
Thu 8/68:30 pm
SCL
- GSP
1 stop21h 40m
American Airlines
Deal found 4/22![American Airlines logo]()
$1,030
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
GSP
- SCL
1 stop25h 05m
American Airlines
Thu 8/68:30 pm
SCL
- GSP
1 stop21h 40m
American Airlines
Deal found 4/26![American Airlines logo]()
$1,035
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:03 am
GSP
- SCL
1 stop19h 32m
Multiple Airlines
Wed 5/272:22 am
SCL
- GSP
2 stops17h 17m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$1,040
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This FlightHub deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Thu 10/1510:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 4/25![LATAM Airlines logo]()
$819
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:08 pm
CHS
- SCL
1 stop10h 42m
American Airlines
Sat 10/249:30 pm
SCL
- CHS
1 stop13h 44m
American Airlines
Deal found 4/23![American Airlines logo]()
$875
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1112:48 pm
CLT
- SCL
3 stops24h 42m
Multiple Airlines
Wed 5/133:20 pm
SCL
- CLT
2 stops20h 23m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$880
This Copa Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:44 pm
CLT
- SCL
2 stops26h 59m
Copa Airlines
Mon 8/3111:22 am
SCL
- CLT
2 stops22h 20m
Copa Airlines
Deal found 4/22![Copa Airlines logo]()
$978
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2511:44 am
GSP
- SCL
1 stop19h 31m
Delta
Thu 8/68:40 pm
SCL
- GSP
1 stop17h 21m
Delta
Deal found 4/25![Delta logo]()
$1,115
This LATAM Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:15 pm
CHS
- SCL
2 stops16h 45m
LATAM Airlines
Sat 10/246:00 pm
SCL
- CHS
2 stops18h 26m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$875
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:58 pm
CLT
- SCL
2 stops47h 25m
Multiple Airlines
Thu 5/288:30 am
SCL
- CLT
2 stops27h 13m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$884
This Justfly.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:15 pm
CLT
- SCL
1 stop17h 10m
LATAM Airlines
Tue 8/1810:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 4/26![LATAM Airlines logo]()
$912
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:00 am
CLT
- SCL
2 stops22h 17m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$929
This Copa Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:44 pm
CLT
- SCL
2 stops33h 19m
Copa Airlines
Fri 8/142:27 am
SCL
- CLT
2 stops31h 15m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$1,028
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/151:37 pm
GSP
- SCL
2 stops17h 28m
American Airlines
Thu 8/68:30 pm
SCL
- GSP
2 stops17h 32m
American Airlines
Deal found 4/26![American Airlines logo]()
$1,030
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/612:19 pm
CLT
- SCL
2 stops17h 41m
Delta
Fri 2/57:45 pm
SCL
- CLT
2 stops17h 19m
Delta
Deal found 4/23![Delta logo]()
$1,125
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:54 pm
GSP
- SCL
2 stops18h 11m
American Airlines
Thu 8/68:30 pm
SCL
- GSP
2 stops16h 35m
American Airlines
Deal found 4/25![American Airlines logo]()
$1,030
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:30 am
CLT
- SCL
2 stops30h 45m
Multiple Airlines
Tue 5/193:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$986
This KAYAK deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2511:38 am
GSP
- SCL
3 stops23h 11m
LATAM Airlines
Thu 8/67:50 am
SCL
- GSP
2 stops16h 04m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$1,107
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/92:35 pm
GSP
- SCL
2 stops16h 30m
American Airlines
Tue 6/169:00 pm
SCL
- GSP
2 stops17h 07m
American Airlines
Deal found 4/21![American Airlines logo]()
$1,130
This LATAM Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:44 pm
GSP
- SCL
1 stop11h 31m
LATAM Airlines
Sun 7/1911:05 pm
SCL
- GSP
2 stops19h 50m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$1,165
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:18 pm
SAV
- SCL
1 stop10h 32m
American Airlines
Sat 8/298:30 pm
SCL
- SAV
2 stops17h 46m
American Airlines
Deal found 4/23![American Airlines logo]()
$1,300
This KAYAK deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:05 pm
GSP
- SCL
1 stop14h 10m
LATAM Airlines
Mon 5/254:50 pm
SCL
- GSP
2 stops17h 45m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$1,203
This LATAM Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:26 pm
SAV
- SCL
3 stops24h 59m
LATAM Airlines
Tue 8/257:20 am
SCL
- SAV
2 stops28h 00m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$1,290
This LATAM Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:30 pm
MYR
- SCL
1 stop17h 45m
LATAM Airlines
Sat 5/234:10 am
SCL
- MYR
2 stops19h 49m
LATAM Airlines
Deal found 4/24![LATAM Airlines logo]()
$1,365
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated April 26, 2026 and is based on user searches.
This KAYAK deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:40 pm
CHS
- SCL
2 stops23h 43m
Copa Airlines
Mon 4/2711:25 am
SCL
- CHS
2 stops22h 58m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$1,180
This Mytrip deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:48 pm
CLT
- SCL
2 stops16h 42m
Multiple Airlines
Tue 6/23:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$754
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1112:48 pm
CLT
- SCL
3 stops24h 42m
Multiple Airlines
Wed 5/133:20 pm
SCL
- CLT
3 stops32h 20m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$838
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Tue 5/193:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$776
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:03 am
GSP
- SCL
1 stop19h 32m
Multiple Airlines
Wed 5/272:22 am
SCL
- GSP
2 stops17h 17m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$1,040
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:58 pm
CLT
- SCL
2 stops47h 25m
Multiple Airlines
Thu 5/288:30 am
SCL
- CLT
2 stops27h 13m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$884
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:48 pm
CLT
- SCL
1 stop18h 07m
Multiple Airlines
Thu 5/285:00 am
SCL
- CLT
2 stops30h 43m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$893
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:00 pm
GSP
- SCL
2 stops18h 05m
American Airlines
Mon 5/259:00 pm
SCL
- GSP
2 stops17h 07m
American Airlines
Deal found 4/22![American Airlines logo]()
$1,200
This KAYAK deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:05 pm
GSP
- SCL
1 stop14h 10m
LATAM Airlines
Mon 5/254:50 pm
SCL
- GSP
2 stops17h 45m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$1,203
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:48 pm
CLT
- SCL
2 stops16h 42m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$844
This FlightHub deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:05 pm
GSP
- SCL
2 stops13h 50m
LATAM Airlines
Thu 5/2811:00 pm
SCL
- GSP
2 stops19h 53m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$1,212
This eDestinos deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:58 pm
CLT
- SCL
3 stops34h 02m
Multiple Airlines
Mon 6/111:17 am
SCL
- CLT
2 stops29h 26m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$763
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:44 pm
CHS
- SCL
2 stops35h 16m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:49 pm
CLT
- SCL
3 stops36h 06m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:57 pm
CLT
- SCL
3 stops45h 59m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:07 am
CLT
- SCL
2 stops21h 28m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:28 pm
GSP
- SCL
3 stops30h 57m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$414
This Cheapflightsfares deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:14 pm
CLT
- SCL
1 stop16h 11m
LATAM Airlines
Deal found 4/22![LATAM Airlines logo]()
$577
This FlightHub deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:38 am
GSP
- SCL
1 stop19h 37m
LATAM Airlines
Deal found 4/25![LATAM Airlines logo]()
$648
This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:03 pm
CHS
- SCL
1 stop13h 12m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$648
This Expedia deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:52 pm
CHS
- SCL
2 stops37h 23m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$1,323
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:26 pm
CHS
- SCL
3 stops55h 59m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$1,489
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated April 26, 2026.
Round-trip from | $720 (Mytrip) |
|---|---|
One-way from | $354 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 10/5
1:15 pm-6:25 am
1 stop16h 10m
Santiago Arturo Merino Benitez
Thu 10/15
10:55 pm-1:54 pm
1 stop15h 59m
$819
Quickest round-trip
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 10/15
8:08 pm-7:50 am
1 stop10h 42m
Santiago Arturo Merino Benitez
Sat 10/24
9:30 pm-10:14 am
1 stop13h 44m
$875
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 10/15
12:15 pm-6:00 am
2 stops16h 45m
Santiago Arturo Merino Benitez
Sat 10/24
6:00 pm-11:26 am
2 stops18h 26m
$875
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 5/11
12:48 pm-1:30 pm
3 stops24h 42m
Santiago Arturo Merino Benitez
Wed 5/13
3:20 pm-11:43 am
2 stops20h 23m
$880
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 5/19
7:58 pm-7:23 pm
2 stops47h 25m
Santiago Arturo Merino Benitez
Thu 5/28
8:30 am-11:43 am
2 stops27h 13m
$884
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 8/10
1:15 pm-6:25 am
1 stop17h 10m
Santiago Arturo Merino Benitez
Tue 8/18
10:55 pm-1:52 pm
1 stop14h 57m
$912
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 5/22
6:00 am-4:17 am
2 stops22h 17m
Santiago Arturo Merino Benitez
Mon 5/25
3:20 pm-11:40 pm
2 stops32h 20m
$929
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/4
7:44 pm-10:43 pm
2 stops26h 59m
Santiago Arturo Merino Benitez
Mon 8/31
11:22 am-9:42 am
2 stops22h 20m
$978
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 5/12
7:30 am-2:15 pm
2 stops30h 45m
Santiago Arturo Merino Benitez
Tue 5/19
3:20 pm-11:40 pm
2 stops32h 20m
$986
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 8/7
7:44 pm-5:03 am
2 stops33h 19m
Santiago Arturo Merino Benitez
Fri 8/14
2:27 am-9:42 am
2 stops31h 15m
$1,028
Showing 1-10 of 30 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CHS-SCL
CLT-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CHS-SCL
CLT-SCL
GSP-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on April 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$753 | Average$948 | FlexibilityNo cancel fee | On-timeN/A |