$380+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jul 1 — Jul 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 1, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 1, 2026.
This LATAM Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:54 pm
CLT
- SCL
2 stops17h 31m
LATAM Airlines
Mon 8/3111:05 pm
SCL
- CLT
2 stops19h 37m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$678
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:24 pm
CLT
- SCL
2 stops16h 50m
Multiple Airlines
Mon 8/2411:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$703
This LATAM Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Fri 11/2011:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/30![LATAM Airlines logo]()
$821
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:02 pm
CLT
- SCL
2 stops30h 18m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$846
This Copa Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:00 am
CLT
- SCL
2 stops19h 38m
Copa Airlines
Thu 11/191:22 am
SCL
- CLT
2 stops34h 22m
Copa Airlines
Deal found 5/28![Copa Airlines logo]()
$858
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:17 pm
SAV
- SCL
1 stop10h 43m
American Airlines
Tue 12/1511:45 pm
SCL
- SAV
1 stop20h 42m
American Airlines
Deal found 5/29![American Airlines logo]()
$925
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:24 am
GSP
- SCL
1 stop20h 36m
American Airlines
Tue 12/110:15 pm
SCL
- GSP
1 stop13h 41m
American Airlines
Deal found 5/27![American Airlines logo]()
$925
This KAYAK deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:15 pm
GSP
- SCL
1 stop13h 35m
Multiple Airlines
Mon 11/3010:45 pm
SCL
- GSP
1 stop25h 01m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$934
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:15 pm
GSP
- SCL
1 stop13h 35m
United Airlines
Thu 12/310:45 pm
SCL
- GSP
1 stop25h 01m
United Airlines
Deal found 5/27![United Airlines logo]()
$935
This LATAM Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm
CHS
- SCL
1 stop11h 16m
LATAM Airlines
Sun 10/2511:25 pm
SCL
- CHS
2 stops20h 29m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$935
This KAYAK deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:23 pm
GSP
- SCL
2 stops16h 27m
Azul
Mon 11/3010:45 pm
SCL
- GSP
1 stop25h 01m
Azul
Deal found 5/27![Azul logo]()
$939
This KAYAK deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:49 pm
CLT
- SCL
1 stop16h 36m
LATAM Airlines
Mon 8/2410:55 pm
SCL
- CLT
1 stop19h 56m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$943
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 1, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 1, 2026.
This LATAM Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:12 pm
CLT
- SCL
3 stops23h 13m
LATAM Airlines
Mon 8/313:20 pm
SCL
- CLT
2 stops18h 53m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$682
This Copa Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:23 am
CLT
- SCL
2 stops31h 52m
Copa Airlines
Fri 11/2012:15 pm
SCL
- CLT
2 stops23h 29m
Copa Airlines
Deal found 5/27![Copa Airlines logo]()
$858
This Trip.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:48 pm
CLT
- SCL
2 stops42h 47m
Multiple Airlines
Sun 8/235:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$858
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:17 pm
SAV
- SCL
1 stop10h 43m
American Airlines
Tue 12/1511:45 pm
SCL
- SAV
1 stop20h 42m
American Airlines
Deal found 5/29![American Airlines logo]()
$925
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:15 pm
GSP
- SCL
1 stop13h 35m
United Airlines
Thu 12/310:45 pm
SCL
- GSP
1 stop25h 01m
United Airlines
Deal found 5/27![United Airlines logo]()
$935
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:05 pm
SAV
- SCL
2 stops21h 00m
Delta
Wed 7/2211:05 pm
SCL
- SAV
2 stops19h 54m
Delta
Deal found 5/30![Delta logo]()
$1,065
This LATAM Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm
CHS
- SCL
1 stop11h 16m
LATAM Airlines
Sun 10/2511:25 pm
SCL
- CHS
2 stops20h 29m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$935
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
SAV
- SCL
1 stop25h 50m
American Airlines
Thu 9/249:30 pm
SCL
- SAV
2 stops19h 10m
American Airlines
Deal found 5/30![American Airlines logo]()
$1,038
This KAYAK deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:49 pm
CLT
- SCL
1 stop16h 36m
LATAM Airlines
Sun 8/2312:40 am
SCL
- CLT
2 stops17h 38m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$947
This Travelocity deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm
CHS
- SCL
1 stop11h 16m
LATAM Airlines
Sun 10/2512:25 am
SCL
- CHS
2 stops19h 29m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$961
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/29:41 am
CHS
- SCL
2 stops20h 19m
Delta
Thu 7/97:55 pm
SCL
- CHS
2 stops22h 59m
Delta
Deal found 5/30![Delta logo]()
$1,185
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Mon 8/318:50 pm
SCL
- GSP
1 stop25h 09m
American Airlines
Deal found 5/30![American Airlines logo]()
$1,085
This Expedia deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:34 pm
CHS
- SCL
1 stop36h 51m
Multiple Airlines
Sun 7/56:40 am
SCL
- CHS
2 stops37h 16m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$1,207
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:35 pm
SAV
- SCL
1 stop15h 15m
United Airlines
Sun 11/110:45 pm
SCL
- SAV
1 stop20h 55m
United Airlines
Deal found 5/28![United Airlines logo]()
$1,285
This Expedia deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:00 am
CLT
- SCL
2 stops17h 25m
LATAM Airlines
Sat 11/285:00 pm
SCL
- CLT
2 stops32h 53m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$975
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:34 pm
CHS
- SCL
1 stop11h 26m
American Airlines
Wed 7/229:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 5/30![American Airlines logo]()
$1,125
This LATAM Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:00 pm
GSP
- SCL
2 stops15h 25m
LATAM Airlines
Sun 11/2911:25 pm
SCL
- GSP
2 stops21h 24m
LATAM Airlines
Deal found 5/27![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:54 pm
MYR
- SCL
2 stops24h 11m
Delta
Thu 7/28:40 pm
SCL
- MYR
1 stop16h 24m
Delta
Deal found 5/31![Delta logo]()
$1,325
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:13 pm
CHS
- SCL
1 stop10h 47m
American Airlines
Thu 7/239:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 5/29![American Airlines logo]()
$1,125
This LATAM Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:55 pm
GSP
- SCL
2 stops18h 30m
LATAM Airlines
Sun 11/111:05 pm
SCL
- GSP
2 stops26h 32m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$996
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:00 pm
GSP
- SCL
1 stop11h 00m
American Airlines
Mon 7/209:00 pm
SCL
- GSP
2 stops17h 04m
American Airlines
Deal found 5/29![American Airlines logo]()
$1,180
This Expedia deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am
SAV
- SCL
2 stops20h 35m
LATAM Airlines
Tue 12/1512:05 am
SCL
- SAV
2 stops18h 28m
LATAM Airlines
Deal found 5/29![LATAM Airlines logo]()
$1,041
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:57 pm
SAV
- SCL
1 stop13h 08m
American Airlines
Sat 8/228:50 pm
SCL
- SAV
1 stop23h 08m
American Airlines
Deal found 5/27![American Airlines logo]()
$1,235
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:53 pm
MYR
- SCL
2 stops18h 12m
American Airlines
Thu 7/29:00 pm
SCL
- MYR
2 stops23h 03m
American Airlines
Deal found 5/31![American Airlines logo]()
$1,250
This KAYAK deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1412:37 pm
SAV
- SCL
3 stops23h 48m
LATAM Airlines
Thu 9/247:50 am
SCL
- SAV
2 stops17h 05m
LATAM Airlines
Deal found 5/30![LATAM Airlines logo]()
$1,210
This LATAM Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/121:05 pm
CHS
- SCL
3 stops21h 44m
LATAM Airlines
Sun 7/194:50 pm
SCL
- CHS
2 stops19h 10m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$1,235
This KAYAK deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:17 pm
MYR
- SCL
3 stops21h 08m
LATAM Airlines
Wed 7/112:40 am
SCL
- MYR
2 stops21h 10m
LATAM Airlines
Deal found 5/31![LATAM Airlines logo]()
$1,330
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated June 1, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated June 1, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:14 pm
CLT
- SCL
1 stop16h 11m
LATAM Airlines
Mon 6/811:05 pm
SCL
- CLT
1 stop19h 41m
LATAM Airlines
Deal found 5/30![LATAM Airlines logo]()
$1,337
This KAYAK deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:18 am
CHS
- SCL
2 stops17h 45m
Copa Airlines
Thu 6/412:01 am
SCL
- CHS
2 stops21h 47m
Copa Airlines
Deal found 5/30![Copa Airlines logo]()
$1,145
This Expedia deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
CHS
- SCL
1 stop24h 25m
Multiple Airlines
Fri 6/56:40 am
SCL
- CHS
2 stops25h 59m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$1,382
This Cheapflightsfares deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:43 am
CHS
- SCL
1 stop20h 32m
LATAM Airlines
Fri 6/58:40 pm
SCL
- CHS
1 stop22h 15m
LATAM Airlines
Deal found 5/30![LATAM Airlines logo]()
$1,513
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:29 pm
CLT
- SCL
2 stops34h 14m
Multiple Airlines
Sat 6/278:30 am
SCL
- CLT
2 stops32h 44m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$1,093
This KAYAK deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/181:50 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Sat 6/2711:05 pm
SCL
- CLT
1 stop19h 41m
LATAM Airlines
Deal found 5/31![LATAM Airlines logo]()
$1,204
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:45 pm
CLT
- SCL
1 stop11h 30m
Delta
Thu 7/28:40 pm
SCL
- CLT
1 stop22h 26m
Delta
Deal found 5/28![Delta logo]()
$1,124
This Expedia deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/286:24 pm
CHS
- SCL
2 stops36h 31m
Multiple Airlines
Sat 7/412:30 am
SCL
- CHS
2 stops43h 26m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$1,183
This Cheapflightsfares deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2811:05 am
CHS
- SCL
1 stop20h 10m
LATAM Airlines
Sun 7/58:40 pm
SCL
- CHS
1 stop22h 14m
LATAM Airlines
Deal found 5/31![LATAM Airlines logo]()
$1,275
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:53 pm
MYR
- SCL
2 stops18h 12m
American Airlines
Thu 7/29:00 pm
SCL
- MYR
2 stops23h 03m
American Airlines
Deal found 5/31![American Airlines logo]()
$1,250
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:54 pm
MYR
- SCL
2 stops24h 11m
Delta
Thu 7/28:40 pm
SCL
- MYR
1 stop16h 24m
Delta
Deal found 5/31![Delta logo]()
$1,325
This KAYAK deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:17 pm
MYR
- SCL
3 stops21h 08m
LATAM Airlines
Wed 7/112:40 am
SCL
- MYR
2 stops21h 10m
LATAM Airlines
Deal found 5/31![LATAM Airlines logo]()
$1,330
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 1, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated June 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1512:29 pm
CLT
- SCL
2 stops16h 34m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:22 pm
CLT
- SCL
3 stops37h 38m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:00 pm
CHS
- SCL
3 stops53h 35m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$437
This Trip.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2612:29 pm
CLT
- SCL
2 stops26h 31m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$506
This Cheapflightsfares deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:45 pm
CLT
- SCL
1 stop11h 30m
LATAM Airlines
Deal found 5/31![LATAM Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1211:04 am
CHS
- SCL
1 stop19h 56m
American Airlines
Deal found 5/28![American Airlines logo]()
$628
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/134:44 pm
CLT
- SCL
1 stop14h 21m
American Airlines
Deal found 5/31![American Airlines logo]()
$678
This Cheapflightsfares deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/121:05 pm
CHS
- SCL
2 stops16h 55m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$1,327
This BusinessClass deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2312:15 pm
CHS
- SCL
2 stops15h 45m
LATAM Airlines
Deal found 5/27![LATAM Airlines logo]()
$1,701
This BusinessClass deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:27 am
CHS
- SCL
1 stop21h 33m
GOL
Deal found 5/27![GOL logo]()
$2,051
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated June 1, 2026.
Round-trip from | $678 (LATAM Airlines) |
|---|---|
One-way from | $380 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 1, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 8/27
2:12 pm-1:25 pm
3 stops23h 13m
Santiago Arturo Merino Benitez
Mon 8/31
3:20 pm-10:13 am
2 stops18h 53m
$682
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 11/9
10:23 am-8:15 pm
2 stops31h 52m
Santiago Arturo Merino Benitez
Fri 11/20
12:15 pm-9:44 am
2 stops23h 29m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/11
6:48 pm-1:35 pm
2 stops42h 47m
Santiago Arturo Merino Benitez
Sun 8/23
5:00 am-5:14 pm
2 stops36h 14m
$858
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
Thu 11/26
8:17 pm-9:00 am
1 stop10h 43m
Santiago Arturo Merino Benitez
Tue 12/15
11:45 pm-6:27 pm
1 stop20h 42m
$925
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 11/3
5:15 pm-8:50 am
1 stop13h 35m
Santiago Arturo Merino Benitez
Thu 12/3
10:45 pm-9:46 pm
1 stop25h 01m
$935
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Fri 10/16
7:59 pm-8:15 am
1 stop11h 16m
Santiago Arturo Merino Benitez
Sun 10/25
11:25 pm-6:54 pm
2 stops20h 29m
$935
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 8/12
1:49 pm-6:25 am
1 stop16h 36m
Santiago Arturo Merino Benitez
Sun 8/23
12:40 am-6:18 pm
2 stops17h 38m
$947
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Fri 10/16
7:59 pm-8:15 am
1 stop11h 16m
Santiago Arturo Merino Benitez
Sun 10/25
12:25 am-6:54 pm
2 stops19h 29m
$961
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 11/20
10:00 am-5:25 am
2 stops17h 25m
Santiago Arturo Merino Benitez
Sat 11/28
5:00 pm-11:53 pm
2 stops32h 53m
$975
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 11/3
12:00 pm-5:25 am
2 stops15h 25m
Santiago Arturo Merino Benitez
Sun 11/29
11:25 pm-6:49 pm
2 stops21h 24m
$995
Showing 1-10 of 36 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
MYR-SCL
SAV-SCL
GSP-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
MYR-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on June 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 1, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |