$271+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
jul. 10 — jul. 171
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 10, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 10, 2026.
This FlightHub deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/97:05 pm
CLT
- SCL
2 stops17h 00m
LATAM Airlines
vie. 11/2011:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$840
This Copa Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/96:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
jue. 11/191:22 am
SCL
- CLT
2 stops34h 22m
Copa Airlines
Deal found 6/5![Copa Airlines logo]()
$858
This LATAM Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/191:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
dom. 11/811:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$862
This LATAM Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/196:30 am
CHS
- SCL
2 stops21h 30m
LATAM Airlines
mar. 12/111:10 pm
SCL
- CHS
1 stop19h 41m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/244:40 pm
GSP
- SCL
2 stops14h 25m
American Airlines
lun. 9/79:50 pm
SCL
- GSP
2 stops19h 20m
American Airlines
Deal found 6/9![American Airlines logo]()
$890
This LATAM Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/186:59 pm
CLT
- SCL
2 stops24h 56m
LATAM Airlines
sáb. 11/2811:25 pm
SCL
- CLT
2 stops26h 28m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$899
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/186:24 pm
CHS
- SCL
1 stop12h 51m
LATAM Airlines
sáb. 7/259:30 pm
SCL
- CHS
2 stops38h 30m
LATAM Airlines
Deal found 6/10![LATAM Airlines logo]()
$911
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/185:00 pm
CHS
- SCL
1 stop14h 15m
Delta
sáb. 7/2510:55 pm
SCL
- CHS
1 stop22h 35m
Delta
Deal found 6/10![Delta logo]()
$915
This Orbitz deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/191:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
dom. 11/812:10 am
SCL
- CLT
1 stop12h 54m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$920
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/228:02 pm
CLT
- SCL
2 stops30h 58m
Multiple Airlines
mié. 7/2911:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$923
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/310:56 am
SAV
- SCL
1 stop20h 04m
American Airlines
mié. 11/1810:15 pm
SCL
- SAV
1 stop14h 02m
American Airlines
Deal found 6/7![American Airlines logo]()
$925
This LATAM Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/2012:15 pm
CHS
- SCL
2 stops15h 45m
LATAM Airlines
mar. 12/15:40 am
SCL
- CHS
2 stops20h 16m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$925
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 10, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 10, 2026.
This FlightHub deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/91:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
vie. 11/2011:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 6/5![LATAM Airlines logo]()
$840
This Copa Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/96:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
jue. 11/191:22 am
SCL
- CLT
2 stops34h 22m
Copa Airlines
Deal found 6/5![Copa Airlines logo]()
$858
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/246:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
lun. 9/79:50 pm
SCL
- GSP
2 stops17h 27m
American Airlines
Deal found 6/9![American Airlines logo]()
$890
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/185:00 pm
CHS
- SCL
1 stop14h 15m
Delta
sáb. 7/2510:55 pm
SCL
- CHS
1 stop22h 35m
Delta
Deal found 6/10![Delta logo]()
$915
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/186:50 am
CHS
- SCL
2 stops39h 53m
United Airlines
vie. 7/242:14 am
SCL
- CHS
2 stops30h 37m
United Airlines
Deal found 6/10![United Airlines logo]()
$1,088
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/1010:03 am
GSP
- SCL
1 stop19h 32m
Multiple Airlines
dom. 7/196:40 am
SCL
- GSP
2 stops32h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$1,183
This Copa Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/197:50 pm
CLT
- SCL
2 stops30h 26m
Copa Airlines
sáb. 11/73:19 am
SCL
- CLT
2 stops32h 25m
Copa Airlines
Deal found 6/7![Copa Airlines logo]()
$858
This LATAM Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/1811:45 am
CLT
- SCL
2 stops16h 15m
LATAM Airlines
sáb. 11/2811:25 pm
SCL
- CLT
2 stops35h 15m
LATAM Airlines
Deal found 6/5![LATAM Airlines logo]()
$899
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/310:56 am
SAV
- SCL
1 stop20h 04m
American Airlines
mié. 11/1810:15 pm
SCL
- SAV
1 stop14h 02m
American Airlines
Deal found 6/7![American Airlines logo]()
$925
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/206:30 am
CHS
- SCL
2 stops21h 30m
Delta
sáb. 11/2811:25 pm
SCL
- CHS
2 stops36h 17m
Delta
Deal found 6/7![Delta logo]()
$975
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/186:24 pm
CHS
- SCL
1 stop12h 51m
LATAM Airlines
sáb. 7/259:30 pm
SCL
- CHS
2 stops38h 30m
LATAM Airlines
Deal found 6/10![LATAM Airlines logo]()
$911
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/3010:28 am
SAV
- SCL
2 stops21h 22m
American Airlines
mié. 10/149:30 pm
SCL
- SAV
1 stop13h 30m
American Airlines
Deal found 6/6![American Airlines logo]()
$980
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/45:05 pm
GSP
- SCL
1 stop12h 35m
LATAM Airlines
mar. 12/811:10 pm
SCL
- GSP
1 stop12h 15m
LATAM Airlines
Deal found 6/9![LATAM Airlines logo]()
$945
This KAYAK deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/107:49 pm
GSP
- SCL
2 stops23h 47m
Copa Airlines
dom. 7/194:21 am
SCL
- GSP
2 stops29h 34m
Copa Airlines
Deal found 6/5![Copa Airlines logo]()
$1,085
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/3010:14 am
SAV
- SCL
1 stop21h 01m
Delta
mié. 10/147:15 am
SCL
- SAV
2 stops17h 44m
Delta
Deal found 6/5![Delta logo]()
$1,105
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/77:34 pm
CHS
- SCL
1 stop11h 26m
American Airlines
mié. 7/229:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 6/8![American Airlines logo]()
$1,041
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/23:35 pm
SAV
- SCL
1 stop15h 15m
United Airlines
dom. 12/610:45 pm
SCL
- SAV
1 stop20h 55m
United Airlines
Deal found 6/8![United Airlines logo]()
$1,285
This LATAM Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/2112:15 pm
CHS
- SCL
2 stops15h 45m
LATAM Airlines
sáb. 11/2811:25 pm
SCL
- CHS
2 stops26h 31m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$975
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/136:28 pm
CHS
- SCL
2 stops19h 37m
Delta
jue. 7/237:55 pm
SCL
- CHS
2 stops16h 05m
Delta
Deal found 6/7![Delta logo]()
$1,175
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/411:25 am
MYR
- SCL
2 stops19h 25m
United Airlines
mar. 12/810:45 pm
SCL
- MYR
2 stops20h 04m
United Airlines
Deal found 6/6![United Airlines logo]()
$1,340
This FlightHub deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/122:12 pm
CLT
- SCL
2 stops16h 43m
LATAM Airlines
lun. 8/2411:00 pm
SCL
- CLT
2 stops19h 42m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$1,016
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/241:37 pm
GSP
- SCL
2 stops17h 28m
American Airlines
lun. 8/318:50 pm
SCL
- GSP
2 stops17h 57m
American Airlines
Deal found 6/7![American Airlines logo]()
$1,130
This Expedia deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/35:35 pm
SAV
- SCL
1 stop12h 05m
LATAM Airlines
mié. 11/1812:10 am
SCL
- SAV
1 stop13h 08m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$1,026
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/2111:42 am
GSP
- SCL
2 stops18h 18m
Delta
mar. 7/287:55 pm
SCL
- GSP
2 stops15h 02m
Delta
Deal found 6/8![Delta logo]()
$1,255
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/1411:36 am
CLT
- SCL
1 stop19h 14m
American Airlines
dom. 10/189:30 pm
SCL
- CLT
1 stop14h 06m
American Airlines
Deal found 6/9![American Airlines logo]()
$1,143
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/46:45 pm
MYR
- SCL
2 stops25h 10m
LATAM Airlines
mar. 12/811:25 pm
SCL
- MYR
2 stops26h 10m
LATAM Airlines
Deal found 6/9![LATAM Airlines logo]()
$1,057
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/138:13 pm
CHS
- SCL
1 stop10h 47m
American Airlines
jue. 7/239:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 6/9![American Airlines logo]()
$1,168
This Cheapflightsfares deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/222:16 pm
CLT
- SCL
1 stop16h 59m
LATAM Airlines
mié. 7/298:40 pm
SCL
- CLT
1 stop21h 39m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,122
This Expedia deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/3012:37 pm
SAV
- SCL
2 stops16h 23m
LATAM Airlines
mié. 10/1412:05 am
SCL
- SAV
2 stops18h 38m
LATAM Airlines
Deal found 6/5![LATAM Airlines logo]()
$1,143
This LATAM Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/146:59 pm
CLT
- SCL
2 stops17h 06m
LATAM Airlines
dom. 10/1811:05 pm
SCL
- CLT
2 stops25h 48m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$1,143
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated junio 10, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated junio 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/1012:29 pm
CLT
- SCL
2 stops17h 31m
Multiple Airlines
mar. 6/1610:30 am
SCL
- CLT
1 stop22h 46m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$1,159
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/2512:29 pm
CLT
- SCL
2 stops17h 31m
Multiple Airlines
jue. 7/210:30 am
SCL
- CLT
1 stop30h 44m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$1,079
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/77:34 pm
CHS
- SCL
1 stop11h 26m
American Airlines
mié. 7/229:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 6/8![American Airlines logo]()
$1,041
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/812:24 pm
CLT
- SCL
2 stops16h 50m
Multiple Airlines
mar. 7/1412:40 am
SCL
- CLT
1 stop16h 32m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$1,004
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/85:39 pm
CLT
- SCL
1 stop13h 36m
LATAM Airlines
mié. 7/158:40 pm
SCL
- CLT
1 stop14h 41m
LATAM Airlines
Deal found 6/9![LATAM Airlines logo]()
$1,124
This KAYAK deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/107:49 pm
GSP
- SCL
2 stops23h 47m
Copa Airlines
dom. 7/194:21 am
SCL
- GSP
2 stops29h 34m
Copa Airlines
Deal found 6/5![Copa Airlines logo]()
$1,085
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/186:24 pm
CHS
- SCL
1 stop12h 51m
LATAM Airlines
sáb. 7/259:30 pm
SCL
- CHS
2 stops38h 30m
LATAM Airlines
Deal found 6/10![LATAM Airlines logo]()
$911
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/185:00 pm
CHS
- SCL
1 stop14h 15m
Delta
sáb. 7/2510:55 pm
SCL
- CHS
1 stop22h 35m
Delta
Deal found 6/10![Delta logo]()
$915
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/186:50 am
CHS
- SCL
2 stops39h 53m
United Airlines
vie. 7/242:14 am
SCL
- CHS
2 stops30h 37m
United Airlines
Deal found 6/10![United Airlines logo]()
$1,088
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/2111:07 am
GSP
- SCL
2 stops14h 43m
Multiple Airlines
mar. 7/288:40 pm
SCL
- GSP
1 stop14h 17m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$1,151
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/228:02 pm
CLT
- SCL
2 stops30h 58m
Multiple Airlines
mié. 7/2911:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$923
This Cheapflightsfares deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/222:16 pm
CLT
- SCL
1 stop16h 59m
LATAM Airlines
mié. 7/298:40 pm
SCL
- CLT
1 stop21h 39m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,122
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated junio 10, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated junio 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/248:45 pm
GSP
- SCL
2 stops30h 15m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/132:19 pm
CLT
- SCL
3 stops44h 46m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/142:19 pm
CLT
- SCL
2 stops36h 16m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/1612:10 pm
CLT
- SCL
3 stops38h 46m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/233:27 pm
CHS
- SCL
2 stops36h 19m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/1012:10 pm
CLT
- SCL
3 stops34h 29m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/158:02 pm
CLT
- SCL
2 stops33h 12m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$426
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/127:41 pm
CLT
- SCL
3 stops33h 54m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/158:11 pm
CLT
- SCL
2 stops26h 28m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/111:33 pm
CLT
- SCL
2 stops15h 27m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$499
This KAYAK deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/232:25 pm
CHS
- SCL
3 stops21h 05m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/246:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Deal found 6/9![American Airlines logo]()
$610
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated junio 10, 2026.
Round-trip from | $840 (FlightHub) |
|---|---|
One-way from | $271 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 10, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
lun. 11/9
1:15 pm-7:50 am
1 stop16h 35m
Santiago Arturo Merino Benitez
vie. 11/20
11:55 pm-1:54 pm
1 stop15h 59m
$840
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
lun. 11/9
6:00 am-11:36 pm
2 stops15h 36m
Santiago Arturo Merino Benitez
jue. 11/19
1:22 am-9:44 am
2 stops34h 22m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
lun. 10/19
7:50 pm-3:16 am
2 stops30h 26m
Santiago Arturo Merino Benitez
sáb. 11/7
3:19 am-9:44 am
2 stops32h 25m
$858
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
lun. 8/24
6:40 pm-7:05 am
1 stop12h 25m
Santiago Arturo Merino Benitez
lun. 9/7
9:50 pm-2:17 pm
2 stops17h 27m
$890
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
mié. 11/18
11:45 am-6:00 am
2 stops16h 15m
Santiago Arturo Merino Benitez
sáb. 11/28
11:25 pm-8:40 am
2 stops35h 15m
$899
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
sáb. 7/18
6:24 pm-7:15 am
1 stop12h 51m
Santiago Arturo Merino Benitez
sáb. 7/25
9:30 pm-12:00 pm
2 stops38h 30m
$911
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
sáb. 7/18
5:00 pm-7:15 am
1 stop14h 15m
Santiago Arturo Merino Benitez
sáb. 7/25
10:55 pm-9:30 pm
1 stop22h 35m
$915
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
mar. 11/3
10:56 am-9:00 am
1 stop20h 04m
Santiago Arturo Merino Benitez
mié. 11/18
10:15 pm-10:17 am
1 stop14h 02m
$925
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
vie. 12/4
5:05 pm-7:40 am
1 stop12h 35m
Santiago Arturo Merino Benitez
mar. 12/8
11:10 pm-9:25 am
1 stop12h 15m
$945
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
vie. 11/20
6:30 am-6:00 am
2 stops21h 30m
Santiago Arturo Merino Benitez
sáb. 11/28
11:25 pm-9:42 am
2 stops36h 17m
$975
Showing 1-10 of 44 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
GSP-SCL
CLT-SCL
CHS-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
GSP-SCL
CLT-SCL
CHS-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on junio 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on junio 10, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |