$474+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 28 — Dec 51
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:12 pm -
1 stop13h 38m
Thu 12/1710:45 pm -
1 stop19h 49m
Deal found 10/25![United Airlines logo]()
$1,156
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Thu 12/179:50 pm -
1 stop15h 23m
Deal found 10/25![Delta logo]()
$1,172
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:00 pm -
2 stops37h 50m
Sun 12/2010:45 pm -
2 stops38h 08m
Deal found 10/29![United Airlines logo]()
$1,180
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:49 am -
1 stop24h 01m
Thu 12/1710:45 pm -
1 stop19h 49m
Deal found 10/25![United Airlines logo]()
$1,186
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:20 am -
2 stops24h 30m
Fri 12/1810:45 pm -
2 stops24h 06m
Deal found 10/25![United Airlines logo]()
$1,190
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:12 pm -
1 stop17h 28m
Sat 12/199:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:12 pm -
2 stops16h 48m
Sat 12/1911:10 pm -
2 stops14h 49m
Deal found 10/25![LATAM Airlines logo]()
$1,200
This Cheapflightsfares deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:18 pm -
1 stop12h 22m
Fri 12/189:50 pm -
1 stop12h 53m
Deal found 10/26![LATAM Airlines logo]()
$1,200
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Fri 12/189:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,202
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:16 pm -
1 stop11h 09m
Fri 12/1811:20 pm -
1 stop16h 03m
Deal found 10/25![American Airlines logo]()
$1,206
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Sat 12/1911:10 pm -
2 stops20h 46m
Deal found 10/25![Delta logo]()
$1,207
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:10 am -
1 stop24h 30m
Sun 12/209:50 pm -
1 stop19h 36m
Deal found 10/29![Delta logo]()
$1,211
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2912:20 pm -
2 stops19h 05m
Mon 2/111:15 pm -
2 stops17h 53m
Deal found 10/28![American Airlines logo]()
$1,130
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/204:58 pm -
1 stop13h 52m
Tue 3/910:45 pm -
1 stop19h 27m
Deal found 10/26![United Airlines logo]()
$1,156
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/13:42 pm -
1 stop13h 58m
Wed 3/318:40 pm -
1 stop19h 09m
Deal found 10/29![Delta logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/243:42 pm -
1 stop12h 58m
Sun 3/76:05 pm -
2 stops26h 44m
Deal found 10/28![LATAM Airlines logo]()
$1,166
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/12:23 pm -
1 stop15h 22m
Wed 3/319:35 pm -
2 stops18h 56m
Deal found 10/28![American Airlines logo]()
$1,160
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/206:00 am -
1 stop22h 55m
Tue 3/911:10 pm -
1 stop21h 44m
Deal found 10/29![Delta logo]()
$1,176
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:00 pm -
2 stops37h 50m
Sun 12/2010:45 pm -
2 stops38h 08m
Deal found 10/29![United Airlines logo]()
$1,180
This Cheapflightsfares deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/155:03 pm -
1 stop12h 37m
Sun 1/2411:00 pm -
1 stop21h 17m
Deal found 10/27![LATAM Airlines logo]()
$1,200
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:10 pm -
1 stop12h 30m
Fri 12/189:50 pm -
1 stop16h 14m
Deal found 10/25![Delta logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/112:04 pm -
1 stop14h 36m
Fri 12/188:40 am -
2 stops17h 24m
Deal found 10/26![LATAM Airlines logo]()
$1,206
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:12 pm -
1 stop17h 28m
Sat 12/199:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,196
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Fri 12/189:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,202
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/155:03 pm -
2 stops19h 57m
Sun 1/248:25 pm -
2 stops15h 48m
Deal found 10/27![Delta logo]()
$1,206
This LATAM Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/296:45 pm -
2 stops19h 20m
Thu 4/17:00 pm -
2 stops23h 55m
Deal found 10/26![LATAM Airlines logo]()
$1,612
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/272:00 pm -
1 stop15h 40m
Sat 12/199:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,226
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated October 29, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated October 29, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:12 pm -
1 stop13h 38m
Thu 12/1710:45 pm -
1 stop19h 49m
Deal found 10/25![United Airlines logo]()
$1,156
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:20 am -
2 stops24h 30m
Fri 12/1810:45 pm -
2 stops24h 06m
Deal found 10/25![United Airlines logo]()
$1,190
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:12 pm -
1 stop17h 28m
Sat 12/199:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:12 pm -
2 stops16h 48m
Sat 12/1911:10 pm -
2 stops14h 49m
Deal found 10/25![LATAM Airlines logo]()
$1,200
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:49 am -
1 stop24h 01m
Thu 12/1710:45 pm -
1 stop19h 49m
Deal found 10/25![United Airlines logo]()
$1,186
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:16 pm -
1 stop11h 09m
Fri 12/1811:20 pm -
1 stop16h 03m
Deal found 10/25![American Airlines logo]()
$1,206
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:00 am -
2 stops24h 50m
Fri 12/1810:45 pm -
2 stops24h 06m
Deal found 10/25![United Airlines logo]()
$1,220
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Thu 12/177:40 am -
2 stops16h 42m
Deal found 10/25![Delta logo]()
$1,172
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Fri 12/189:50 pm -
1 stop13h 34m
Deal found 10/25![Delta logo]()
$1,202
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:19 pm -
1 stop34h 21m
Sat 12/1911:10 pm -
2 stops20h 46m
Deal found 10/25![Delta logo]()
$1,207
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
This eDestinos deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:08 pm -
3 stops36h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2912:08 pm -
3 stops39h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$507
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:03 pm -
3 stops33h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$533
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:21 pm -
2 stops36h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$594
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1511:28 am -
3 stops30h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$664
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:16 pm -
1 stop12h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$729
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/155:00 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$745
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/298:10 pm -
1 stop11h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$756
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:30 am -
2 stops19h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$772
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![LATAM Airlines logo]()
$775
This LATAM Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:18 pm -
3 stops21h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![LATAM Airlines logo]()
$903
This AranGrant deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/205:25 pm -
2 stops37h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Azul logo]()
$1,329
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 29, 2026.
Round-trip from | $1,126 (American Airlines) |
|---|---|
One-way from | $474 (eDestinos) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 11/3
4:03 pm-3:38 am
3 stops33h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$533
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 11/3
1:21 pm-3:38 am
2 stops36h 17m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$594
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Tue 12/15
11:28 am-8:11 pm
3 stops30h 43m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$664
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 11/3
6:16 pm-8:45 am
1 stop12h 29m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$729
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Tue 12/15
5:00 pm-8:50 am
1 stop13h 50m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$745
Quickest round-trip
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sun 11/29
8:10 pm-9:25 am
1 stop11h 15m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$756
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
11:30 am-8:50 am
2 stops19h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$772
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$775
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 1/29
12:20 pm-9:25 am
2 stops19h 05m
Santiago Arturo Merino Benitez
Mon 2/1
11:15 pm-3:08 pm
2 stops17h 53m
$1,130
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sat 2/20
4:58 pm-8:50 am
1 stop13h 52m
Santiago Arturo Merino Benitez
Tue 3/9
10:45 pm-4:12 pm
1 stop19h 27m
$1,156
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CHS-SCL
GSP-SCL
MYR-SCL
Estimated round-trip price
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Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CHS-SCL
GSP-SCL
MYR-SCL
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Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
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South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on October 29, 2026.
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 29, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$704 | Average$975 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$745 | Average$1,134 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$763 | Average$974 | FlexibilityNo cancel fee | On-timeN/A |