$201+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Mar 16 — Mar 231
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Fri 4/312:35 pm
SCL
- CLT
2 stops24h 32m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$523
This Mytrip deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$528
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
2 stops22h 40m
Multiple Airlines
Mon 4/611:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$540
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:37 pm
CLT
- SCL
3 stops37h 23m
Multiple Airlines
Mon 3/2311:25 pm
SCL
- CLT
1 stop35h 22m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$553
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
CLT
- SCL
2 stops22h 30m
Multiple Airlines
Thu 4/1611:00 pm
SCL
- CLT
1 stop14h 43m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$556
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:15 am
CLT
- SCL
2 stops23h 15m
Multiple Airlines
Mon 4/1311:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$559
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:08 pm
CLT
- SCL
2 stops29h 57m
Multiple Airlines
Thu 5/2111:00 pm
SCL
- CLT
1 stop21h 28m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$561
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
CLT
- SCL
2 stops23h 15m
Multiple Airlines
Thu 4/1611:00 pm
SCL
- CLT
1 stop14h 43m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$578
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
CLT
- SCL
2 stops23h 15m
Multiple Airlines
Mon 4/1311:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$582
This Mytrip deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:00 am
CLT
- SCL
2 stops22h 40m
Multiple Airlines
Tue 3/241:35 am
SCL
- CLT
3 stops35h 32m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$601
This FlightHub deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
GSP
- SCL
2 stops21h 05m
LATAM Airlines
Wed 4/1511:00 pm
SCL
- GSP
2 stops19h 55m
LATAM Airlines
Deal found 2/11![LATAM Airlines logo]()
$766
This Ovago deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
LATAM Airlines
Wed 4/18:40 pm
SCL
- SAV
1 stop28h 16m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$788
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 14, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 14, 2026.
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Fri 4/312:35 pm
SCL
- CLT
2 stops24h 32m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$523
This Ovago deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
LATAM Airlines
Wed 4/18:40 pm
SCL
- SAV
1 stop28h 16m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$788
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
SAV
- SCL
1 stop23h 00m
American Airlines
Wed 4/19:25 pm
SCL
- SAV
1 stop22h 39m
American Airlines
Deal found 2/13![American Airlines logo]()
$828
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
2 stops22h 40m
Multiple Airlines
Mon 4/68:30 am
SCL
- CLT
2 stops27h 37m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$550
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:17 am
CLT
- SCL
2 stops27h 23m
Multiple Airlines
Sat 4/48:30 am
SCL
- CLT
2 stops17h 23m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$615
This LATAM Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:25 pm
CHS
- SCL
1 stop18h 50m
LATAM Airlines
Sun 5/311:05 pm
SCL
- CHS
2 stops19h 33m
LATAM Airlines
Deal found 2/11![LATAM Airlines logo]()
$797
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:18 am
CLT
- SCL
1 stop19h 37m
Multiple Airlines
Mon 3/2311:25 pm
SCL
- CLT
1 stop35h 22m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$676
This Ovago deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:41 pm
GSP
- SCL
1 stop13h 34m
LATAM Airlines
Wed 4/158:40 pm
SCL
- GSP
1 stop13h 40m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$798
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/284:30 pm
GSP
- SCL
1 stop14h 30m
American Airlines
Sat 4/49:25 pm
SCL
- GSP
1 stop22h 31m
American Airlines
Deal found 2/11![American Airlines logo]()
$900
This Avianca Connect deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:12 am
CLT
- SCL
2 stops17h 33m
Multiple Airlines
Sat 5/912:30 am
SCL
- CLT
2 stops19h 58m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$705
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:59 pm
SAV
- SCL
1 stop13h 01m
American Airlines
Sat 4/49:25 pm
SCL
- SAV
2 stops23h 30m
American Airlines
Deal found 2/11![American Airlines logo]()
$905
This Ovago deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:59 pm
GSP
- SCL
1 stop11h 16m
LATAM Airlines
Sun 4/58:40 pm
SCL
- GSP
1 stop14h 25m
LATAM Airlines
Deal found 2/12![LATAM Airlines logo]()
$849
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
- SCL
2 stops29h 30m
Multiple Airlines
Mon 3/306:00 am
SCL
- CLT
2 stops31h 07m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$715
This LATAM Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:30 am
GSP
- SCL
2 stops20h 05m
LATAM Airlines
Sat 4/48:45 pm
SCL
- GSP
2 stops15h 20m
LATAM Airlines
Deal found 2/11![LATAM Airlines logo]()
$866
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/198:55 am
CLT
- SCL
2 stops19h 01m
Multiple Airlines
Sun 5/2411:00 pm
SCL
- CLT
1 stop34h 17m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$720
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:25 pm
CLT
- SCL
1 stop13h 30m
Multiple Airlines
Mon 3/239:05 pm
SCL
- CLT
2 stops37h 42m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$728
This Gurufare deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:05 pm
MYR
- SCL
2 stops17h 45m
LATAM Airlines
Wed 7/110:55 pm
SCL
- MYR
2 stops20h 09m
LATAM Airlines
Deal found 2/13![LATAM Airlines logo]()
$1,100
This Expedia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/283:13 pm
SAV
- SCL
2 stops38h 12m
Multiple Airlines
Sat 4/410:10 pm
SCL
- SAV
2 stops45h 51m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$885
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated February 14, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated February 14, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:00 am
CLT
- SCL
2 stops22h 40m
Multiple Airlines
Tue 3/241:35 am
SCL
- CLT
3 stops35h 32m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$601
This Mytrip deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$528
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:37 pm
CLT
- SCL
3 stops37h 23m
Multiple Airlines
Mon 3/2311:25 pm
SCL
- CLT
1 stop35h 22m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$553
This Ovago deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:57 pm
SAV
- SCL
1 stop13h 43m
LATAM Airlines
Wed 4/18:40 pm
SCL
- SAV
1 stop28h 16m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$788
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:00 am
SAV
- SCL
1 stop23h 00m
American Airlines
Wed 4/19:25 pm
SCL
- SAV
1 stop22h 39m
American Airlines
Deal found 2/13![American Airlines logo]()
$828
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Fri 4/312:35 pm
SCL
- CLT
2 stops24h 32m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$523
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:17 am
CLT
- SCL
2 stops27h 23m
Multiple Airlines
Sat 4/48:30 am
SCL
- CLT
2 stops17h 23m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$615
This LATAM Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:30 am
GSP
- SCL
2 stops20h 05m
LATAM Airlines
Sat 4/48:45 pm
SCL
- GSP
2 stops15h 20m
LATAM Airlines
Deal found 2/11![LATAM Airlines logo]()
$866
This Expedia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/283:13 pm
SAV
- SCL
2 stops38h 12m
Multiple Airlines
Sat 4/410:10 pm
SCL
- SAV
2 stops45h 51m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$885
This Ovago deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:59 pm
GSP
- SCL
1 stop11h 16m
LATAM Airlines
Sun 4/58:40 pm
SCL
- GSP
1 stop14h 25m
LATAM Airlines
Deal found 2/12![LATAM Airlines logo]()
$849
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
2 stops22h 40m
Multiple Airlines
Mon 4/611:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$540
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
CLT
- SCL
2 stops19h 35m
Multiple Airlines
Mon 4/611:00 pm
SCL
- CLT
1 stop13h 07m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$613
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 14, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:00 am
CLT
- SCL
2 stops54h 40m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:34 pm
CLT
- SCL
2 stops23h 31m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$259
This BusinessClass deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:15 am
CLT
- SCL
1 stop18h 40m
LATAM Airlines
Deal found 2/12![LATAM Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:03 am
CLT
- SCL
1 stop20h 37m
Delta
Deal found 2/10![Delta logo]()
$398
This LATAM Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/33:26 pm
CLT
- SCL
1 stop15h 24m
LATAM Airlines
Deal found 2/11![LATAM Airlines logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:27 pm
SAV
- SCL
3 stops48h 13m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$430
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:55 pm
SAV
- SCL
2 stops19h 35m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$466
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated February 14, 2026.
Round-trip from | $523 (Mytrip) |
|---|---|
One-way from | $201 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
South Carolina
Fly to
Santiago
Route
Depart
Return
Price
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 3/27
7:00 am-2:40 pm
2 stops30h 40m
Santiago Arturo Merino Benitez
Fri 4/3
12:35 pm-12:07 pm
2 stops24h 32m
$523
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 3/30
7:00 am-6:40 am
2 stops22h 40m
Santiago Arturo Merino Benitez
Mon 4/6
8:30 am-12:07 pm
2 stops27h 37m
$550
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 3/28
10:17 am-2:40 pm
2 stops27h 23m
Santiago Arturo Merino Benitez
Sat 4/4
8:30 am-12:53 am
2 stops17h 23m
$615
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 3/16
9:18 am-5:55 am
1 stop19h 37m
Santiago Arturo Merino Benitez
Mon 3/23
11:25 pm-9:47 am
1 stop35h 22m
$676
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 5/5
11:12 am-4:45 am
2 stops17h 33m
Santiago Arturo Merino Benitez
Sat 5/9
12:30 am-8:28 pm
2 stops19h 58m
$705
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/4
7:00 am-2:30 pm
2 stops29h 30m
Santiago Arturo Merino Benitez
Mon 3/30
6:00 am-12:07 pm
2 stops31h 07m
$715
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 5/19
8:55 am-3:56 am
2 stops19h 01m
Santiago Arturo Merino Benitez
Sun 5/24
11:00 pm-9:17 am
1 stop34h 17m
$720
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 3/12
3:25 pm-5:55 am
1 stop13h 30m
Santiago Arturo Merino Benitez
Mon 3/23
9:05 pm-9:47 am
2 stops37h 42m
$728
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
Mon 3/23
4:57 pm-7:40 am
1 stop13h 43m
Santiago Arturo Merino Benitez
Wed 4/1
8:40 pm-11:56 pm
1 stop28h 16m
$788
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 4/29
12:25 pm-7:15 am
1 stop18h 50m
Santiago Arturo Merino Benitez
Sun 5/3
11:05 pm-6:38 pm
2 stops19h 33m
$797
Showing 1-10 of 26 results
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
SAV-SCL
GSP-SCL
CHS-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
SAV-SCL
GSP-SCL
CHS-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
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Alternative routes for South Carolina to Santiago
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Complete your trip
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South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on February 14, 2026.
Popular flight searches
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 14, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$532 | Average$888 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$562 | Average$901 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$845 | FlexibilityNo cancel fee | On-time71% |