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$311+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Aug 27 — Sep 31
Thu 8/27
Thu 9/3
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:52 pm
CLT
-
SCL
2 stops31h 22m
Multiple Airlines
Wed 9/211:00 pm
SCL
-
CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/27$714
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:43 pm
CLT
-
SCL
2 stops28h 07m
Multiple Airlines
Sun 8/3012:35 am
SCL
-
CLT
1 stop16h 11m
Multiple Airlines
Deal found 7/24$778
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:43 pm
CLT
-
SCL
2 stops28h 07m
Multiple Airlines
Wed 9/212:40 am
SCL
-
CLT
1 stop16h 06m
Multiple Airlines
Deal found 7/24$779
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:43 pm
CLT
-
SCL
2 stops49h 00m
Multiple Airlines
Sun 8/3012:35 am
SCL
-
CLT
1 stop16h 11m
Multiple Airlines
Deal found 7/24$791
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:43 pm
CLT
-
SCL
2 stops49h 00m
Multiple Airlines
Wed 9/212:40 am
SCL
-
CLT
1 stop16h 06m
Multiple Airlines
Deal found 7/24$792
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am
CLT
-
SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3012:35 am
SCL
-
CLT
1 stop16h 11m
Multiple Airlines
Deal found 7/25$793
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:43 pm
CLT
-
SCL
2 stops28h 07m
Multiple Airlines
Sun 8/3012:35 am
SCL
-
CLT
1 stop16h 11m
Multiple Airlines
Deal found 7/24$812
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:43 pm
CLT
-
SCL
2 stops28h 07m
Multiple Airlines
Wed 9/212:40 am
SCL
-
CLT
1 stop16h 06m
Multiple Airlines
Deal found 7/24$813
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:36 am
CLT
-
SCL
2 stops18h 24m
Multiple Airlines
Sun 8/3011:00 pm
SCL
-
CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/24$828
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:36 am
CLT
-
SCL
2 stops18h 24m
Multiple Airlines
Wed 9/212:40 am
SCL
-
CLT
1 stop16h 06m
Multiple Airlines
Deal found 7/24$829
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:24 pm
CLT
-
SCL
2 stops16h 50m
Multiple Airlines
Sun 8/3011:00 pm
SCL
-
CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/24$860
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:28 am
CHS
-
SCL
1 stop20h 07m
Multiple Airlines
Tue 9/14:14 am
SCL
-
CHS
2 stops28h 54m
Multiple Airlines
Deal found 7/28$889

Find flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 28, 2026.

Round-trip from

$714
(Kiwi.com)

One-way from

$311
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
Search Deals
One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 8/26

9:52 pm-5:14 am

2 stops31h 22m

Santiago Arturo Merino Benitez

Wed 9/2

11:00 pm-4:46 pm

1 stop17h 46m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 11/4

6:00 am-5:46 am

2 stops21h 46m

Santiago Arturo Merino Benitez

Fri 11/13

1:02 am-10:04 am

2 stops35h 02m

$902

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 9/10

7:05 am-6:55 am

2 stops22h 50m

Santiago Arturo Merino Benitez

Thu 9/17

9:30 am-10:08 am

3 stops25h 38m

$909

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 9/7

6:45 pm-6:25 pm

2 stops22h 40m

Santiago Arturo Merino Benitez

Mon 9/14

11:55 pm-7:13 pm

2 stops20h 18m

$909

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 9/7

10:20 am-8:05 am

2 stops20h 45m

Santiago Arturo Merino Benitez

Mon 9/14

9:30 pm-3:34 pm

1 stop19h 04m

$910

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 9/8

11:07 am-7:25 am

2 stops19h 18m

Santiago Arturo Merino Benitez

Tue 9/15

9:30 pm-3:34 pm

1 stop19h 04m

$910
Quickest round-trip

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 8/25

6:45 pm-7:15 am

1 stop12h 30m

Santiago Arturo Merino Benitez

Sun 8/30

7:55 pm-11:54 am

2 stops15h 59m

$915

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 8/24

12:47 pm-6:25 am

1 stop17h 38m

Santiago Arturo Merino Benitez

Tue 9/1

8:40 pm-11:54 am

1 stop15h 14m

$915

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 10/28

12:31 pm-5:30 pm

2 stops27h 59m

Santiago Arturo Merino Benitez

Sun 11/1

5:00 pm-5:14 pm

2 stops26h 14m

$915

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 8/24

8:10 am-5:55 am

2 stops21h 45m

Santiago Arturo Merino Benitez

Mon 8/31

8:40 pm-10:08 am

1 stop13h 28m

$915

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/24

Showing 1-10 of 42 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 20h 45m. Copa Airlines provides one of the quickest options available for as low as $910. The distance between South Carolina and Santiago is about 4616 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Greenville - Santiago Arturo Merino Benitez and Charleston - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from South Carolina to Santiago

Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$664Average$859FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$704Average$914FlexibilityNo cancel feeOn-time71%
DeltaCheapest$743Average$954FlexibilityNo cancel feeOn-timeN/A

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