$360+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Sep 11 — Sep 181
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
This Trip.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:11 pm -
2 stops32h 19m
Wed 11/41:35 am -
2 stops17h 03m
Deal found 8/10![Multiple Airlines logo]()
$577
This Trip.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:32 am -
2 stops37h 48m
Wed 9/161:30 am -
3 stops34h 44m
Deal found 8/10![Multiple Airlines logo]()
$717
This Trip.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops38h 24m
Wed 9/26:40 am -
2 stops25h 21m
Deal found 8/12![Multiple Airlines logo]()
$720
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:11 pm -
2 stops29h 35m
Wed 11/411:10 pm -
1 stop18h 30m
Deal found 8/10![Multiple Airlines logo]()
$779
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:02 pm -
2 stops27h 44m
Wed 11/411:10 pm -
1 stop18h 30m
Deal found 8/10![Multiple Airlines logo]()
$780
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:02 pm -
2 stops27h 44m
Wed 11/411:10 pm -
1 stop18h 30m
Deal found 8/10![Multiple Airlines logo]()
$781
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:59 pm -
2 stops28h 36m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/11![Multiple Airlines logo]()
$789
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops16h 14m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/9![Multiple Airlines logo]()
$800
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:07 am -
2 stops19h 18m
Mon 9/149:30 pm -
2 stops19h 12m
Deal found 8/9![American Airlines logo]()
$910
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:47 pm -
1 stop17h 38m
Thu 8/2710:55 pm -
1 stop17h 32m
Deal found 8/9![Delta logo]()
$915
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:06 pm -
2 stops13h 49m
Tue 8/2510:55 pm -
1 stop17h 32m
Deal found 8/9![Delta logo]()
$920
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:13 pm -
2 stops16h 52m
Wed 8/268:50 pm -
2 stops19h 45m
Deal found 8/11![American Airlines logo]()
$926
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:59 pm -
1 stop15h 56m
Mon 11/95:07 am -
2 stops16h 48m
Deal found 8/8![Multiple Airlines logo]()
$867
This Copa Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
2 stops19h 38m
Fri 11/131:22 am -
2 stops19h 26m
Deal found 8/8![Copa Airlines logo]()
$908
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:07 am -
2 stops19h 18m
Tue 9/159:30 pm -
1 stop19h 04m
Deal found 8/9![American Airlines logo]()
$910
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:59 pm -
1 stop32h 41m
Thu 12/2411:55 pm -
1 stop17h 49m
Deal found 8/9![Delta logo]()
$911
This LATAM Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:00 pm -
1 stop15h 40m
Sun 12/64:05 pm -
2 stops28h 04m
Deal found 8/10![LATAM Airlines logo]()
$965
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:45 am -
2 stops22h 25m
Mon 9/281:43 am -
2 stops20h 39m
Deal found 8/8![United Airlines logo]()
$1,154
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:00 am -
1 stop23h 25m
Mon 9/149:30 pm -
1 stop19h 04m
Deal found 8/9![American Airlines logo]()
$914
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:30 am -
2 stops21h 25m
Tue 12/2210:15 am -
2 stops15h 38m
Deal found 8/9![Delta logo]()
$954
This LATAM Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:06 am -
2 stops21h 49m
Mon 12/77:30 am -
2 stops17h 12m
Deal found 8/9![LATAM Airlines logo]()
$1,047
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:52 am -
2 stops17h 03m
Thu 12/2411:00 pm -
1 stop19h 04m
Deal found 8/9![Delta logo]()
$954
This oojo deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:20 am -
2 stops17h 15m
Tue 12/228:35 am -
3 stops28h 43m
Deal found 8/12![LATAM Airlines logo]()
$1,072
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:52 am -
2 stops17h 03m
Sun 12/2011:10 pm -
2 stops16h 21m
Deal found 8/9![Delta logo]()
$999
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:00 am -
1 stop23h 50m
Thu 2/410:45 pm -
1 stop18h 33m
Deal found 8/7![United Airlines logo]()
$1,309
This Expedia deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:37 pm -
2 stops59h 18m
Sat 9/1210:30 pm -
2 stops44h 01m
Deal found 8/8![LATAM Airlines logo]()
$1,099
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:30 am -
1 stop20h 30m
Tue 12/2210:15 pm -
1 stop15h 07m
Deal found 8/12![American Airlines logo]()
$1,247
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:59 pm -
1 stop11h 16m
Sun 12/138:25 pm -
2 stops22h 38m
Deal found 8/9![Delta logo]()
$1,047
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:05 pm -
1 stop14h 10m
Sun 12/64:50 am -
2 stops19h 52m
Deal found 8/9![Delta logo]()
$1,047
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/63:20 pm -
2 stops39h 30m
Tue 12/810:45 pm -
2 stops20h 04m
Deal found 8/7![United Airlines logo]()
$1,399
This LATAM Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/13:42 pm -
1 stop13h 58m
Thu 2/49:55 pm -
2 stops27h 42m
Deal found 8/7![LATAM Airlines logo]()
$1,197
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:15 am -
1 stop23h 10m
Tue 12/811:10 pm -
1 stop12h 07m
Deal found 8/9![Delta logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:10 pm -
2 stops32h 25m
Tue 12/811:10 pm -
1 stop14h 37m
Deal found 8/7![LATAM Airlines logo]()
$1,292
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:37 pm -
1 stop12h 38m
Fri 12/119:50 pm -
1 stop13h 27m
Deal found 8/9![Delta logo]()
$1,077
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:15 pm -
1 stop13h 35m
Sun 12/610:45 pm -
1 stop18h 33m
Deal found 8/10![United Airlines logo]()
$1,597
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:01 pm -
1 stop14h 14m
Mon 10/2610:55 pm -
1 stop15h 44m
Deal found 8/11![Delta logo]()
$1,084
This LATAM Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:11 pm -
2 stops23h 34m
Tue 9/17:55 pm -
2 stops15h 59m
Deal found 8/11![LATAM Airlines logo]()
$1,342
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:44 am -
2 stops19h 06m
Tue 10/277:30 am -
2 stops17h 24m
Deal found 8/11![Delta logo]()
$1,084
This LATAM Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:01 pm -
2 stops32h 34m
Tue 12/811:10 pm -
1 stop12h 57m
Deal found 8/7![LATAM Airlines logo]()
$1,406
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:23 pm -
1 stop16h 52m
Mon 10/2611:10 pm -
1 stop15h 28m
Deal found 8/11![Delta logo]()
$1,084
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:51 am -
1 stop18h 49m
Tue 11/311:55 pm -
1 stop15h 44m
Deal found 8/10![Delta logo]()
$1,084
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated August 12, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated August 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:24 pm -
2 stops16h 50m
Sat 8/228:30 am -
2 stops32h 16m
Deal found 8/11![Multiple Airlines logo]()
$825
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:01 pm -
2 stops17h 54m
Tue 8/257:50 am -
2 stops16h 09m
Deal found 8/9![Delta logo]()
$920
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:13 pm -
2 stops16h 52m
Wed 8/268:50 pm -
2 stops19h 45m
Deal found 8/11![American Airlines logo]()
$926
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/152:06 pm -
2 stops16h 59m
Wed 8/268:50 pm -
2 stops16h 26m
Deal found 8/9![American Airlines logo]()
$940
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:01 pm -
2 stops16h 54m
Thu 8/278:40 pm -
1 stop13h 40m
Deal found 8/9![Delta logo]()
$915
This Trip.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops38h 24m
Wed 9/26:40 am -
2 stops25h 21m
Deal found 8/12![Multiple Airlines logo]()
$720
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:58 pm -
2 stops15h 37m
Sun 8/3011:00 pm -
1 stop17h 46m
Deal found 8/11![Multiple Airlines logo]()
$912
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:56 am -
2 stops20h 59m
Sun 9/1311:55 pm -
1 stop22h 19m
Deal found 8/10![Multiple Airlines logo]()
$897
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:07 am -
2 stops19h 18m
Mon 9/149:30 pm -
2 stops19h 12m
Deal found 8/9![American Airlines logo]()
$910
This Trip.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:32 am -
2 stops37h 48m
Wed 9/161:30 am -
3 stops34h 44m
Deal found 8/10![Multiple Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:59 pm -
2 stops28h 36m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/11![Multiple Airlines logo]()
$789
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops16h 14m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/9![Multiple Airlines logo]()
$800
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/229:39 pm -
2 stops20h 36m
Deal found 8/9![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:58 pm -
2 stops21h 17m
Deal found 8/8![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:23 pm -
3 stops55h 09m
Deal found 8/7![Multiple Airlines logo]()
$382
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:47 pm -
3 stops46h 28m
Deal found 8/9![Multiple Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/304:03 pm -
2 stops28h 32m
Deal found 8/8![Multiple Airlines logo]()
$438
This oojo deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:52 am -
2 stops17h 08m
Deal found 8/11![LATAM Airlines logo]()
$570
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:55 am -
2 stops17h 50m
Deal found 8/7![Multiple Airlines logo]()
$608
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:00 pm -
1 stop13h 50m
Deal found 8/8![United Airlines logo]()
$619
This Cheapflightsfares deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:04 pm -
1 stop15h 36m
Deal found 8/9![LATAM Airlines logo]()
$649
This Expedia deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/298:30 pm -
2 stops26h 00m
Deal found 8/11![Multiple Airlines logo]()
$651
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:25 am -
2 stops19h 25m
Deal found 8/10![United Airlines logo]()
$662
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/293:50 pm -
3 stops24h 10m
Deal found 8/11![LATAM Airlines logo]()
$664
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated August 12, 2026.
Round-trip from | $577 (Trip.com) |
|---|---|
One-way from | $360 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Mon 10/26
1:59 pm-6:55 am
1 stop15h 56m
Santiago Arturo Merino Benitez
Mon 11/9
5:07 am-7:55 pm
2 stops16h 48m
$867
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Fri 11/6
6:00 am-3:38 am
2 stops19h 38m
Santiago Arturo Merino Benitez
Fri 11/13
1:22 am-6:48 pm
2 stops19h 26m
$908
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 9/8
11:07 am-7:25 am
2 stops19h 18m
Santiago Arturo Merino Benitez
Tue 9/15
9:30 pm-3:34 pm
1 stop19h 04m
$910
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Sun 12/13
7:59 pm-6:40 am
1 stop32h 41m
Santiago Arturo Merino Benitez
Thu 12/24
11:55 pm-3:44 pm
1 stop17h 49m
$911
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 9/8
7:00 am-7:25 am
1 stop23h 25m
Santiago Arturo Merino Benitez
Mon 9/14
9:30 pm-3:34 pm
1 stop19h 04m
$914
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Sat 12/12
7:30 am-6:55 am
2 stops21h 25m
Santiago Arturo Merino Benitez
Tue 12/22
10:15 am-11:53 pm
2 stops15h 38m
$954
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Fri 12/11
11:52 am-6:55 am
2 stops17h 03m
Santiago Arturo Merino Benitez
Thu 12/24
11:00 pm-4:04 pm
1 stop19h 04m
$954
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 12/2
2:00 pm-7:40 am
1 stop15h 40m
Santiago Arturo Merino Benitez
Sun 12/6
4:05 pm-6:09 pm
2 stops28h 04m
$965
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Fri 12/11
11:52 am-6:55 am
2 stops17h 03m
Santiago Arturo Merino Benitez
Sun 12/20
11:10 pm-1:31 pm
2 stops16h 21m
$999
SavannahSantiago
SAV Savannah/Hilton Head - SCL Santiago Arturo Merino Benitez
SAVSCL
Savannah/Hilton Head
Thu 8/27
8:06 am-5:55 am
2 stops21h 49m
Santiago Arturo Merino Benitez
Mon 12/7
7:30 am-10:42 pm
2 stops17h 12m
$1,047
Showing 1-10 of 47 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on August 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 12, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |