$747+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Oct 31 — Nov 71
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
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Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:13 am -
2 stops17h 27m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/30![Delta logo]()
$1,085
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 pm -
1 stop13h 50m
Sun 11/110:45 pm -
1 stop19h 34m
Deal found 9/29![United Airlines logo]()
$1,105
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:54 am -
2 stops19h 51m
Thu 11/1910:30 pm -
2 stops19h 06m
Deal found 9/28![American Airlines logo]()
$1,113
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:52 pm -
3 stops26h 23m
Thu 10/88:20 am -
2 stops16h 39m
Deal found 9/30![LATAM Airlines logo]()
$1,120
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops24h 30m
Thu 11/1910:45 pm -
1 stop19h 43m
Deal found 9/28![United Airlines logo]()
$1,125
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 pm -
2 stops59h 50m
Sat 11/2110:45 pm -
2 stops38h 36m
Deal found 9/30![United Airlines logo]()
$1,130
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:12 pm -
1 stop17h 28m
Thu 11/1911:10 pm -
1 stop13h 57m
Deal found 9/28![Delta logo]()
$1,135
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:42 am -
1 stop19h 03m
Sat 11/2110:30 pm -
1 stop14h 22m
Deal found 9/30![American Airlines logo]()
$1,135
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:12 pm -
3 stops24h 08m
Thu 11/198:25 pm -
2 stops16h 42m
Deal found 9/28![LATAM Airlines logo]()
$1,143
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 pm -
1 stop12h 30m
Thu 10/89:30 pm -
1 stop27h 29m
Deal found 9/30![American Airlines logo]()
$1,147
This SmartFares deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:18 pm -
1 stop17h 22m
Sat 1/168:15 am -
3 stops28h 43m
Deal found 9/30![LATAM Airlines logo]()
$1,160
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2910:53 am -
1 stop20h 07m
Mon 2/111:45 pm -
1 stop18h 12m
Deal found 9/27![American Airlines logo]()
$1,075
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/136:00 am -
2 stops24h 50m
Thu 1/2810:45 pm -
2 stops25h 16m
Deal found 9/29![United Airlines logo]()
$1,080
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:12 pm -
1 stop17h 28m
Thu 11/1911:10 pm -
1 stop13h 57m
Deal found 9/28![Delta logo]()
$1,135
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:45 am -
3 stops25h 56m
Sun 3/74:35 pm -
2 stops28h 14m
Deal found 9/28![LATAM Airlines logo]()
$1,135
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/137:00 am -
1 stop22h 45m
Thu 1/2811:45 pm -
1 stop15h 19m
Deal found 9/29![American Airlines logo]()
$1,075
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops24h 30m
Thu 11/1910:45 pm -
1 stop19h 43m
Deal found 9/28![United Airlines logo]()
$1,125
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
This Cheapflightsfares deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/152:18 pm -
1 stop15h 22m
Sun 11/2211:10 pm -
1 stop12h 57m
Deal found 10/1![LATAM Airlines logo]()
$1,235
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:00 am -
1 stop23h 50m
Sun 3/710:45 pm -
1 stop18h 33m
Deal found 9/26![United Airlines logo]()
$1,135
This LATAM Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/292:15 pm -
1 stop17h 00m
Thu 4/14:50 am -
2 stops19h 45m
Deal found 9/26![LATAM Airlines logo]()
$1,571
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated October 1, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated October 1, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:13 am -
2 stops17h 27m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/30![Delta logo]()
$1,085
This LATAM Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:52 pm -
3 stops26h 23m
Thu 10/88:20 am -
2 stops16h 39m
Deal found 9/30![LATAM Airlines logo]()
$1,120
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 pm -
1 stop12h 30m
Thu 10/89:30 pm -
1 stop27h 29m
Deal found 9/30![American Airlines logo]()
$1,147
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 pm -
1 stop13h 50m
Sun 11/110:45 pm -
1 stop19h 34m
Deal found 9/29![United Airlines logo]()
$1,105
This LATAM Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:45 am -
1 stop17h 55m
Fri 11/1311:10 pm -
1 stop21h 04m
Deal found 9/27![LATAM Airlines logo]()
$1,165
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:54 am -
2 stops19h 51m
Thu 11/1910:30 pm -
2 stops19h 06m
Deal found 9/28![American Airlines logo]()
$1,113
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops24h 30m
Thu 11/1910:45 pm -
1 stop19h 43m
Deal found 9/28![United Airlines logo]()
$1,125
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:12 pm -
1 stop17h 28m
Thu 11/1911:10 pm -
1 stop13h 57m
Deal found 9/28![Delta logo]()
$1,135
This LATAM Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:12 pm -
3 stops24h 08m
Thu 11/198:25 pm -
2 stops16h 42m
Deal found 9/28![LATAM Airlines logo]()
$1,143
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 pm -
2 stops59h 50m
Sat 11/2110:45 pm -
2 stops38h 36m
Deal found 9/30![United Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:42 am -
1 stop19h 03m
Sat 11/2110:30 pm -
1 stop14h 22m
Deal found 9/30![American Airlines logo]()
$1,135
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:47 pm -
2 stops17h 58m
Sun 11/2210:30 pm -
2 stops21h 46m
Deal found 10/1![American Airlines logo]()
$1,095
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:30 am -
2 stops19h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![United Airlines logo]()
$747
This Cheapflightsfares deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![LATAM Airlines logo]()
$756
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:05 am -
3 stops50h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![LATAM Airlines logo]()
$1,905
This BusinessClass deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:42 am -
2 stops36h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Copa Airlines logo]()
$2,485
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
1 stop25h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$3,615
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 1, 2026.
Round-trip from | $1,075 (American Airlines) |
|---|---|
One-way from | $747 (United Airlines) |
Popular in | December |
Cheapest in | March |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
11:30 am-8:50 am
2 stops19h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$747
Quickest round-trip
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
2:18 pm-7:40 am
1 stop15h 22m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$756
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 1/29
10:53 am-9:00 am
1 stop20h 07m
Santiago Arturo Merino Benitez
Mon 2/1
11:45 pm-3:57 pm
1 stop18h 12m
$1,075
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Wed 1/13
7:00 am-7:45 am
1 stop22h 45m
Santiago Arturo Merino Benitez
Thu 1/28
11:45 pm-1:04 pm
1 stop15h 19m
$1,075
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Wed 1/13
6:00 am-8:50 am
2 stops24h 50m
Santiago Arturo Merino Benitez
Thu 1/28
10:45 pm-10:01 pm
2 stops25h 16m
$1,080
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Sun 11/15
12:47 pm-8:45 am
2 stops17h 58m
Santiago Arturo Merino Benitez
Sun 11/22
10:30 pm-6:16 pm
2 stops21h 46m
$1,095
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 11/12
6:20 am-8:50 am
2 stops24h 30m
Santiago Arturo Merino Benitez
Thu 11/19
10:45 pm-4:28 pm
1 stop19h 43m
$1,125
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 11/12
12:12 pm-7:40 am
1 stop17h 28m
Santiago Arturo Merino Benitez
Thu 11/19
11:10 pm-11:07 am
1 stop13h 57m
$1,135
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 2/24
7:45 am-11:41 am
3 stops25h 56m
Santiago Arturo Merino Benitez
Sun 3/7
4:35 pm-6:49 pm
2 stops28h 14m
$1,135
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 2/24
7:00 am-8:50 am
1 stop23h 50m
Santiago Arturo Merino Benitez
Sun 3/7
10:45 pm-3:18 pm
1 stop18h 33m
$1,135
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CHS-SCL
MYR-SCL
GSP-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CHS-SCL
MYR-SCL
GSP-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on October 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$1,134 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% |