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$316+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
feb. 13 — feb. 201
vie. 2/13
vie. 2/20
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated enero 14, 2026.

Round-trip from

$565
(Kiwi.com)

One-way from

$316
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
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One-way flight from South Carolina to Santiago Arturo Merino Benitez
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Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/67:00 am
CLT
-
SCL
2 stops23h 15m
Multiple Airlines
dom. 3/157:25 am
SCL
-
CLT
2 stops27h 47m
Multiple Airlines
Deal found 1/12$565
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/18:04 pm
CLT
-
SCL
2 stops41h 16m
Multiple Airlines
mié. 2/2511:25 pm
SCL
-
CLT
1 stop20h 25m
Multiple Airlines
Deal found 1/12$605
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 1/2111:35 am
CLT
-
SCL
2 stops18h 05m
Multiple Airlines
mié. 2/2511:25 pm
SCL
-
CLT
1 stop14h 55m
Multiple Airlines
Deal found 1/12$644
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/267:13 pm
CLT
-
SCL
2 stops48h 42m
Multiple Airlines
jue. 3/511:25 pm
SCL
-
CLT
1 stop14h 55m
Multiple Airlines
Deal found 1/12$648
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 1/2111:35 am
CLT
-
SCL
2 stops18h 05m
Multiple Airlines
lun. 2/2311:25 pm
SCL
-
CLT
1 stop14h 55m
Multiple Airlines
Deal found 1/12$656
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/275:55 am
CLT
-
SCL
2 stops38h 00m
Multiple Airlines
vie. 3/611:25 pm
SCL
-
CLT
1 stop12h 32m
Multiple Airlines
Deal found 1/13$661
This Mytrip deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/87:00 am
CLT
-
SCL
2 stops19h 55m
Multiple Airlines
dom. 2/2210:44 am
SCL
-
CLT
2 stops33h 34m
Multiple Airlines
Deal found 1/12$680
This Mytrip deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/99:07 pm
CLT
-
SCL
3 stops28h 53m
Multiple Airlines
lun. 2/239:05 pm
SCL
-
CLT
2 stops17h 15m
Multiple Airlines
Deal found 1/13$691
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/1810:30 am
CHS
-
SCL
1 stop20h 45m
Delta
mar. 9/88:40 pm
SCL
-
CHS
1 stop20h 00m
Delta
Deal found 1/13$725
This LATAM Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/712:45 pm
CHS
-
SCL
1 stop18h 05m
LATAM Airlines
vie. 8/2810:55 pm
SCL
-
CHS
1 stop17h 49m
LATAM Airlines
Deal found 1/13$771
This KAYAK deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/612:04 pm
CHS
-
SCL
1 stop18h 46m
LATAM Airlines
vie. 5/1510:55 pm
SCL
-
CHS
1 stop17h 49m
LATAM Airlines
Deal found 1/12$788
This Ovago deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/2612:34 pm
SAV
-
SCL
1 stop17h 06m
LATAM Airlines
jue. 3/511:10 pm
SCL
-
SAV
1 stop25h 35m
LATAM Airlines
Deal found 1/12$796

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 14, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

vie. 3/6

7:00 am-8:15 am

2 stops23h 15m

Santiago Arturo Merino Benitez

dom. 3/15

10:35 am-10:12 am

1 stop24h 37m

$567

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

jue. 2/26

7:13 pm-9:55 pm

2 stops48h 42m

Santiago Arturo Merino Benitez

jue. 3/5

11:25 pm-12:20 pm

1 stop14h 55m

$648

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

dom. 2/1

6:00 am-5:30 am

2 stops21h 30m

Santiago Arturo Merino Benitez

mié. 2/25

4:25 pm-12:20 pm

2 stops21h 55m

$654

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

dom. 2/8

7:00 am-4:55 am

2 stops19h 55m

Santiago Arturo Merino Benitez

dom. 2/22

10:44 am-6:18 pm

2 stops33h 34m

$680

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 2/9

9:56 pm-4:00 am

2 stops28h 04m

Santiago Arturo Merino Benitez

lun. 2/23

11:25 pm-12:20 pm

1 stop14h 55m

$696

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

vie. 2/27

5:55 am-5:14 am

2 stops21h 19m

Santiago Arturo Merino Benitez

jue. 3/5

4:20 am-9:57 am

2 stops31h 37m

$697

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

mar. 3/24

11:12 am-5:30 am

2 stops17h 18m

Santiago Arturo Merino Benitez

sáb. 4/11

2:30 pm-12:19 pm

2 stops21h 49m

$738

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

mar. 2/17

11:12 am-5:30 am

2 stops16h 18m

Santiago Arturo Merino Benitez

jue. 2/19

4:25 pm-12:20 pm

2 stops21h 55m

$751

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

jue. 2/12

5:55 am-5:30 am

2 stops21h 35m

Santiago Arturo Merino Benitez

jue. 2/19

4:25 pm-12:20 pm

2 stops21h 55m

$763

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

mié. 5/6

3:20 pm-6:50 am

1 stop15h 30m

Santiago Arturo Merino Benitez

vie. 5/15

10:30 am-10:10 am

2 stops23h 40m

$774

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 41 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

How much does it cost to fly round-trip from South Carolina to Santiago?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 16h 35m. LATAM Airlines provides one of the quickest options available for as low as $799. The distance between South Carolina and Santiago is about 4616 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Greenville - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Santiago

Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$571Average$901FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$703Average$845FlexibilityNo cancel feeOn-time71%
DeltaCheapest$793Average$948FlexibilityNo cancel feeOn-timeN/A

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