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$273+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated November 13, 2025.

Round-trip from

$646
(Mytrip)

One-way from

$273
(Trip.com)
From South Carolina to Santiago Arturo Merino Benitez
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One-way flight from South Carolina to Santiago Arturo Merino Benitez
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Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:56 pmCLT - SCL
2 stops35h 34mMultiple Airlines
Thu 12/1111:25 pmSCL - CLT
1 stop21h 45mMultiple Airlines
Deal found 11/12$670
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:56 pmCLT - SCL
2 stops35h 34mMultiple Airlines
Sat 12/1311:25 pmSCL - CLT
1 stop15h 16mMultiple Airlines
Deal found 11/11$679
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:56 pmCLT - SCL
2 stops35h 34mMultiple Airlines
Fri 12/1211:25 pmSCL - CLT
1 stop21h 45mMultiple Airlines
Deal found 11/11$684
This FlightHub deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:38 amCLT - SCL
2 stops15h 57mLATAM Airlines
Tue 12/911:30 pmSCL - CLT
1 stop15h 58mLATAM Airlines
Deal found 11/12$689
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:44 pmCLT - SCL
3 stops57h 31mMultiple Airlines
Sat 12/1311:25 pmSCL - CLT
1 stop15h 16mMultiple Airlines
Deal found 11/11$703
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/211:32 amCLT - SCL
1 stop19h 18mUnited Airlines
Thu 12/1110:45 pmSCL - CLT
1 stop14h 06mUnited Airlines
Deal found 11/11$714
This KAYAK deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:12 pmCLT - SCL
3 stops22h 18mLATAM Airlines
Thu 12/117:15 amSCL - CLT
3 stops18h 27mLATAM Airlines
Deal found 11/12$719
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/139:19 amGSP - SCL
2 stops45h 31mUnited Airlines
Fri 12/1910:45 pmSCL - GSP
2 stops27h 04mUnited Airlines
Deal found 11/11$988
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:35 amGSP - SCL
1 stop22h 35mDelta
Fri 12/1911:10 pmSCL - GSP
1 stop18h 35mDelta
Deal found 11/11$1,374
This Priceline deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:00 pmGSP - SCL
2 stops22h 05mLATAM Airlines
Thu 12/184:32 amSCL - GSP
2 stops21h 10mLATAM Airlines
Deal found 11/11$1,380
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1910:00 amCHS - SCL
2 stops20h 50mUnited Airlines
Tue 11/2510:45 pmSCL - CHS
1 stop19h 31mUnited Airlines
Deal found 11/12$1,514
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:14 pmCHS - SCL
1 stop13h 11mAmerican Airlines
Sat 1/310:25 pmSCL - CHS
1 stop12h 22mAmerican Airlines
Deal found 11/11$1,735

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/9

1:24 pm-10:39 am

2 stops19h 15m

Santiago Arturo Merino Benitez

Tue 2/24

9:05 pm-12:22 pm

2 stops17h 17m

$653

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 12/2

3:56 pm-5:30 am

2 stops35h 34m

Santiago Arturo Merino Benitez

Thu 12/11

11:25 pm-7:10 pm

1 stop21h 45m

$670

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

5:18 pm-3:30 pm

2 stops20h 12m

Santiago Arturo Merino Benitez

Thu 2/5

6:30 pm-12:07 pm

2 stops19h 37m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

5:18 pm-3:30 pm

2 stops20h 12m

Santiago Arturo Merino Benitez

Thu 2/5

11:10 pm-9:24 am

1 stop12h 14m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

3:16 pm-8:15 am

1 stop14h 59m

Santiago Arturo Merino Benitez

Thu 2/5

11:55 pm-6:48 pm

1 stop20h 53m

$704

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 12/3

8:44 pm-8:15 am

3 stops57h 31m

Santiago Arturo Merino Benitez

Fri 12/12

11:25 pm-7:10 pm

1 stop21h 45m

$707

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 12/2

11:32 am-8:50 am

1 stop19h 18m

Santiago Arturo Merino Benitez

Thu 12/11

10:45 pm-10:51 am

1 stop14h 06m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/9

6:59 pm-3:30 pm

2 stops18h 31m

Santiago Arturo Merino Benitez

Mon 2/23

12:20 am-7:10 pm

2 stops20h 50m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 12/2

5:30 pm-7:40 am

1 stop12h 10m

Santiago Arturo Merino Benitez

Sun 12/14

4:35 am-11:42 pm

2 stops21h 07m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 12/2

4:51 pm-8:50 am

1 stop13h 59m

Santiago Arturo Merino Benitez

Mon 12/15

10:45 pm-3:49 pm

1 stop19h 04m

$714

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

One of the essential ways to save on airfare from South Carolina to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.

How much does it cost to fly round-trip from South Carolina to Santiago?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 14h 59m. Delta provides one of the quickest options available for as low as $704. The distance between South Carolina and Santiago is about 4616 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Santiago one-way?

    The cheapest airlines for a one-way flight from South Carolina to Santiago are LATAM Airlines ($510), United Airlines ($513), and American Airlines ($518).

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Myrtle Beach Intl - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$888FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$999FlexibilityNo cancel feeOn-time81%

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