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$294+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 16 — Nov 231
Sun 11/16
Sun 11/23
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 17, 2025.

Round-trip from

$664
(United Airlines)

One-way from

$294
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
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One-way flight from South Carolina to Santiago Arturo Merino Benitez
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Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2025.

This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:05 pmCHS - SCL
1 stop13h 45mUnited Airlines
Mon 11/1710:45 pmSCL - CHS
1 stop19h 31mUnited Airlines
Deal found 10/15$664
This LATAM Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/17:18 pmCLT - SCL
2 stops16h 47mLATAM Airlines
Mon 12/159:30 pmSCL - CLT
1 stop15h 13mLATAM Airlines
Deal found 10/15$714
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:37 pmSAV - SCL
2 stops19h 48mDelta
Tue 10/2812:20 amSCL - SAV
2 stops21h 32mDelta
Deal found 10/15$714
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/194:56 pmGSP - SCL
1 stop13h 54mUnited Airlines
Wed 11/2610:45 pmSCL - GSP
1 stop18h 54mUnited Airlines
Deal found 10/16$714
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:40 amCLT - SCL
2 stops24h 10mUnited Airlines
Mon 12/110:45 pmSCL - CLT
2 stops24h 54mUnited Airlines
Deal found 10/16$719
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/199:10 amGSP - SCL
2 stops21h 40mUnited Airlines
Tue 11/2510:45 pmSCL - GSP
1 stop18h 54mUnited Airlines
Deal found 10/16$719
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:45 amCLT - SCL
1 stop24h 05mUnited Airlines
Mon 12/1510:45 pmSCL - CLT
2 stops25h 14mUnited Airlines
Deal found 10/16$728
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1912:30 pmGSP - SCL
2 stops18h 20mUnited Airlines
Mon 12/110:45 pmSCL - GSP
2 stops38h 59mUnited Airlines
Deal found 10/16$735
This Cheapflightsfares deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:12 pmCLT - SCL
1 stop15h 28mLATAM Airlines
Mon 12/84:35 amSCL - CLT
2 stops21h 14mLATAM Airlines
Deal found 10/15$746
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:28 pmGSP - SCL
2 stops37h 22mUnited Airlines
Mon 12/110:45 pmSCL - GSP
2 stops38h 59mUnited Airlines
Deal found 10/16$751
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/221:24 pmCLT - SCL
1 stop17h 36mAmerican Airlines
Tue 12/210:25 pmSCL - CLT
1 stop17h 14mAmerican Airlines
Deal found 10/15$754
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/224:56 pmGSP - SCL
1 stop13h 54mUnited Airlines
Tue 11/2510:45 pmSCL - GSP
1 stop18h 54mUnited Airlines
Deal found 10/16$754

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 11/13

5:05 pm-8:50 am

1 stop13h 45m

Santiago Arturo Merino Benitez

Mon 11/17

10:45 pm-4:16 pm

1 stop19h 31m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 11/13

8:00 am-5:50 am

2 stops19h 50m

Santiago Arturo Merino Benitez

Mon 11/17

11:10 pm-11:46 am

1 stop14h 36m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 11/13

12:51 pm-7:40 am

1 stop16h 49m

Santiago Arturo Merino Benitez

Mon 11/17

11:10 pm-1:25 pm

1 stop16h 15m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 3/17

4:50 pm-7:50 am

1 stop14h 00m

Santiago Arturo Merino Benitez

Fri 3/27

9:45 pm-3:57 pm

1 stop19h 12m

$704

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 12/1

6:45 pm-9:00 am

1 stop12h 15m

Santiago Arturo Merino Benitez

Mon 12/8

11:55 pm-11:31 am

1 stop13h 36m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 1/5

4:30 pm-6:10 am

1 stop11h 40m

Santiago Arturo Merino Benitez

Mon 1/19

6:30 pm-1:35 pm

2 stops21h 05m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 1/6

10:07 am-7:00 am

1 stop18h 53m

Santiago Arturo Merino Benitez

Tue 1/20

6:30 pm-1:35 pm

2 stops21h 05m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 11/19

4:56 pm-8:50 am

1 stop13h 54m

Santiago Arturo Merino Benitez

Tue 11/25

10:45 pm-3:39 pm

1 stop18h 54m

$714

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 1/5

7:40 am-6:10 am

1 stop20h 30m

Santiago Arturo Merino Benitez

Tue 1/20

11:15 pm-4:03 pm

1 stop18h 48m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 11/19

4:56 pm-8:50 am

1 stop13h 54m

Santiago Arturo Merino Benitez

Mon 12/1

10:45 pm-3:44 pm

1 stop18h 59m

$714

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 45 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 17, 2025.

One of the essential ways to save on airfare from South Carolina to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.

What is the cheapest day to fly from South Carolina to Santiago?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Santiago flight should consider departing on Thursday mornings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 13h 45m. United Airlines provides one of the quickest options available for as low as $664. The distance between South Carolina and Santiago is about 4616 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Santiago one-way?

    The cheapest airlines for a one-way flight from South Carolina to Santiago are Air Canada ($465), United Airlines ($513), and Delta ($518).

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Greenville - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Santiago

Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$900FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$983FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$702Average$722FlexibilityNo cancel feeOn-time71%

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