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$253+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Avianca Connect deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:55 amCLT - SCL
2 stops18h 35mMultiple Airlines
Tue 3/313:30 pmSCL - CLT
2 stops21h 49mMultiple Airlines
Deal found 12/13$857
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:57 amCLT - SCL
1 stop22h 28mAmerican Airlines
Wed 12/3110:25 pmSCL - CLT
1 stop14h 26mAmerican Airlines
Deal found 12/12$984
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:45 pmCLT - SCL
1 stop14h 05mUnited Airlines
Fri 12/2610:45 pmSCL - CLT
1 stop13h 52mUnited Airlines
Deal found 12/15$1,165
This FlightHub deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:38 amCLT - SCL
1 stop16h 32mLATAM Airlines
Tue 3/3111:55 pmSCL - CLT
1 stop15h 50mLATAM Airlines
Deal found 12/13$1,206
This FlightHub deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:51 pmCLT - SCL
3 stops19h 39mLATAM Airlines
Wed 12/3111:30 pmSCL - CLT
1 stop19h 43mLATAM Airlines
Deal found 12/12$1,208
This Expedia deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:12 pmCLT - SCL
1 stop15h 28mMultiple Airlines
Fri 12/198:25 amSCL - CLT
2 stops38h 32mMultiple Airlines
Deal found 12/13$1,249
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:15 pmCLT - SCL
1 stop11h 40mAmerican Airlines
Fri 12/2611:15 pmSCL - CLT
1 stop23h 16mAmerican Airlines
Deal found 12/13$1,264
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:55 pmCLT - SCL
2 stops28h 48mMultiple Airlines
Sun 12/217:15 amSCL - CLT
2 stops34h 41mMultiple Airlines
Deal found 12/13$1,285
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:14 pmCHS - SCL
1 stop13h 11mAmerican Airlines
Sat 1/310:25 pmSCL - CHS
1 stop12h 22mAmerican Airlines
Deal found 12/13$1,910
This oojo deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:03 pmCHS - SCL
2 stops48h 47mMultiple Airlines
Fri 1/212:45 amSCL - CHS
2 stops43h 21mMultiple Airlines
Deal found 12/13$2,292
This Ovago deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:23 pmCHS - SCL
2 stops14h 07mLATAM Airlines
Sat 1/37:15 amSCL - CHS
3 stops18h 43mLATAM Airlines
Deal found 12/13$3,288

Find flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated December 15, 2025.

Round-trip from

$599
(Kiwi.com)

One-way from

$253
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
Search Deals
One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/16

7:00 am-6:40 am

2 stops21h 40m

Santiago Arturo Merino Benitez

Thu 2/26

10:35 am-3:30 pm

1 stop30h 55m

$599

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sun 1/18

3:00 pm-5:35 am

1 stop12h 35m

Santiago Arturo Merino Benitez

Fri 1/23

5:50 am-10:55 am

2 stops31h 05m

$649

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 3/2

2:10 pm-6:55 am

1 stop14h 45m

Santiago Arturo Merino Benitez

Mon 3/16

10:30 pm-2:45 pm

1 stop17h 15m

$654

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 1/12

1:53 pm-7:00 am

1 stop15h 07m

Santiago Arturo Merino Benitez

Fri 1/23

12:35 pm-10:55 am

2 stops24h 20m

$656

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 2/3

6:00 am-5:30 am

2 stops21h 30m

Santiago Arturo Merino Benitez

Sat 2/7

4:25 pm-12:22 pm

2 stops21h 57m

$690

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 1/27

6:00 am-2:40 pm

2 stops30h 40m

Santiago Arturo Merino Benitez

Tue 2/3

12:35 pm-4:54 pm

3 stops30h 19m

$694

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

7:32 am-8:15 am

1 stop22h 43m

Santiago Arturo Merino Benitez

Thu 2/5

10:30 pm-2:25 pm

1 stop17h 55m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

3:20 pm-11:25 pm

2 stops30h 05m

Santiago Arturo Merino Benitez

Thu 2/5

11:10 pm-5:53 pm

1 stop20h 43m

$704

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Mon 1/12

2:19 pm-7:40 am

1 stop15h 21m

Santiago Arturo Merino Benitez

Mon 1/19

9:30 pm-9:46 am

1 stop14h 16m

$732

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Fri 1/23

12:36 pm-2:20 pm

2 stops23h 44m

Santiago Arturo Merino Benitez

Tue 1/27

11:10 pm-9:26 am

1 stop12h 16m

$754

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 41 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

One of the essential ways to save on airfare from South Carolina to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 14h 45m. LATAM Airlines provides one of the quickest options available for as low as $654. The distance between South Carolina and Santiago is about 4783 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Greenville - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$571Average$1,032FlexibilityNo cancel feeOn-time81%
DeltaCheapest$793Average$948FlexibilityNo cancel feeOn-timeN/A

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