$304+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Sep 25 — Oct 21
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:52 pm -
2 stops29h 04m
Tue 9/229:30 am -
2 stops29h 25m
Deal found 8/25![Multiple Airlines logo]()
$721
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:40 pm -
2 stops28h 06m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/23![Multiple Airlines logo]()
$758
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:32 am -
2 stops28h 03m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/23![Multiple Airlines logo]()
$797
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:32 am -
2 stops16h 14m
Wed 10/1411:55 pm -
1 stop22h 01m
Deal found 8/22![Multiple Airlines logo]()
$837
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/411:27 am -
2 stops16h 28m
Sun 10/1111:55 pm -
1 stop22h 01m
Deal found 8/21![Multiple Airlines logo]()
$876
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:30 pm -
2 stops15h 40m
Thu 10/1511:55 pm -
1 stop22h 01m
Deal found 8/23![Multiple Airlines logo]()
$877
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 am -
2 stops20h 59m
Wed 9/211:00 pm -
1 stop17h 46m
Deal found 8/24![Multiple Airlines logo]()
$881
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:45 pm -
2 stops39h 15m
Wed 10/711:55 pm -
1 stop22h 01m
Deal found 8/25![Multiple Airlines logo]()
$889
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:32 am -
2 stops17h 24m
Sat 10/2411:55 pm -
1 stop22h 01m
Deal found 8/22![Multiple Airlines logo]()
$896
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:41 am -
1 stop19h 04m
Tue 11/2410:30 pm -
1 stop14h 22m
Deal found 8/25![American Airlines logo]()
$955
This LATAM Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:50 am -
2 stops22h 25m
Sun 11/19:55 pm -
2 stops28h 04m
Deal found 8/24![LATAM Airlines logo]()
$965
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:00 am -
1 stop23h 50m
Mon 2/110:45 pm -
1 stop18h 33m
Deal found 8/25![United Airlines logo]()
$985
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:40 pm -
2 stops39h 15m
Tue 9/296:00 am -
2 stops32h 55m
Deal found 8/23![Multiple Airlines logo]()
$911
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/111:15 pm -
1 stop15h 40m
Wed 1/208:13 am -
2 stops17h 40m
Deal found 8/24![Delta logo]()
$954
This LATAM Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:05 pm -
2 stops23h 55m
Sun 11/14:05 pm -
2 stops27h 19m
Deal found 8/25![LATAM Airlines logo]()
$965
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 pm -
1 stop13h 50m
Sun 11/110:45 pm -
1 stop19h 34m
Deal found 8/21![United Airlines logo]()
$985
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:39 am -
2 stops20h 31m
Tue 10/139:30 pm -
2 stops17h 01m
Deal found 8/22![American Airlines logo]()
$1,046
This Copa Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:55 pm -
2 stops22h 20m
Tue 11/1712:15 pm -
2 stops48h 27m
Deal found 8/24![Copa Airlines logo]()
$1,199
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:30 am -
2 stops24h 20m
Mon 2/2210:45 pm -
2 stops26h 34m
Deal found 8/25![United Airlines logo]()
$990
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
1 stop22h 55m
Thu 12/249:50 pm -
1 stop14h 43m
Deal found 8/21![Delta logo]()
$1,015
This LATAM Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:45 am -
1 stop18h 55m
Mon 11/211:10 pm -
1 stop21h 47m
Deal found 8/23![LATAM Airlines logo]()
$1,015
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:10 pm -
2 stops18h 50m
Wed 9/169:30 pm -
2 stops15h 07m
Deal found 8/21![American Airlines logo]()
$1,052
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:50 am -
2 stops25h 00m
Mon 11/210:45 pm -
2 stops20h 11m
Deal found 8/22![United Airlines logo]()
$990
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:05 am -
1 stop20h 35m
Thu 2/2511:50 pm -
1 stop24h 26m
Deal found 8/25![Delta logo]()
$1,044
This LATAM Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:58 pm -
1 stop12h 17m
Tue 10/138:40 pm -
1 stop14h 27m
Deal found 8/22![LATAM Airlines logo]()
$1,077
This Copa Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
2 stops20h 56m
Sat 10/245:22 am -
2 stops30h 20m
Deal found 8/22![Copa Airlines logo]()
$1,222
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:47 am -
2 stops19h 28m
Tue 12/811:10 pm -
1 stop14h 03m
Deal found 8/25![Delta logo]()
$1,044
This LATAM Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 pm -
1 stop13h 30m
Wed 9/168:50 am -
2 stops15h 38m
Deal found 8/21![LATAM Airlines logo]()
$1,077
This Copa Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:25 am -
2 stops36h 57m
Tue 10/271:31 am -
2 stops34h 11m
Deal found 8/24![Copa Airlines logo]()
$1,240
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:54 am -
1 stop20h 21m
Wed 9/168:40 pm -
1 stop14h 27m
Deal found 8/21![Delta logo]()
$1,077
This Trip.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:46 pm -
2 stops32h 19m
Wed 1/67:30 am -
2 stops27h 20m
Deal found 8/25![Multiple Airlines logo]()
$1,441
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
2 stops24h 00m
Tue 10/138:40 pm -
1 stop14h 27m
Deal found 8/22![Delta logo]()
$1,077
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:56 pm -
2 stops37h 54m
Thu 11/1910:45 pm -
2 stops26h 45m
Deal found 8/23![United Airlines logo]()
$1,449
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:00 pm -
2 stops18h 00m
Tue 9/298:40 pm -
1 stop17h 50m
Deal found 8/22![Delta logo]()
$1,279
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:40 am -
1 stop19h 45m
Tue 9/228:40 pm -
1 stop22h 44m
Deal found 8/25![Delta logo]()
$1,279
This Travelocity deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:01 pm -
2 stops24h 49m
Wed 1/611:00 pm -
1 stop13h 08m
Deal found 8/25![LATAM Airlines logo]()
$1,732
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2410:46 am -
1 stop17h 54m
Mon 1/410:15 am -
2 stops15h 20m
Deal found 8/23![Delta logo]()
$1,560
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:05 pm -
1 stop16h 35m
Tue 1/511:00 pm -
1 stop13h 08m
Deal found 8/23![Delta logo]()
$1,665
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated August 26, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated August 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:56 am -
2 stops21h 29m
Sat 8/298:40 am -
2 stops32h 06m
Deal found 8/23![Multiple Airlines logo]()
$1,016
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 am -
2 stops20h 59m
Wed 9/211:00 pm -
1 stop17h 46m
Deal found 8/24![Multiple Airlines logo]()
$881
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:45 pm -
2 stops39h 15m
Wed 10/711:55 pm -
1 stop22h 01m
Deal found 8/25![Multiple Airlines logo]()
$889
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:15 am -
2 stops20h 50m
Tue 9/89:50 pm -
2 stops24h 18m
Deal found 8/21![American Airlines logo]()
$1,052
This LATAM Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:18 pm -
2 stops16h 37m
Tue 9/812:05 am -
2 stops22h 36m
Deal found 8/21![LATAM Airlines logo]()
$1,082
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:52 pm -
2 stops29h 04m
Tue 9/229:30 am -
2 stops29h 25m
Deal found 8/25![Multiple Airlines logo]()
$721
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/83:13 pm -
2 stops35h 43m
Fri 9/116:10 am -
2 stops27h 28m
Deal found 8/25![Multiple Airlines logo]()
$1,201
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:54 am -
1 stop20h 21m
Wed 9/168:40 pm -
1 stop14h 27m
Deal found 8/21![Delta logo]()
$1,077
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:32 am -
2 stops28h 03m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/23![Multiple Airlines logo]()
$797
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:59 pm -
2 stops31h 36m
Mon 9/2811:55 pm -
1 stop22h 19m
Deal found 8/22![Multiple Airlines logo]()
$925
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:40 pm -
2 stops28h 06m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/23![Multiple Airlines logo]()
$758
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:40 pm -
2 stops18h 50m
Sun 9/278:55 pm -
2 stops21h 25m
Deal found 8/24![Delta logo]()
$1,045
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 26, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/83:13 pm -
2 stops35h 43m
Deal found 8/25![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:40 pm -
2 stops28h 06m
Deal found 8/23![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:52 pm -
2 stops29h 04m
Deal found 8/23![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:59 pm -
3 stops47h 37m
Deal found 8/23![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:06 pm -
3 stops35h 29m
Deal found 8/23![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:59 pm -
3 stops39h 36m
Deal found 8/23![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
3 stops33h 13m
Deal found 8/23![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:32 am -
2 stops17h 24m
Deal found 8/25![Multiple Airlines logo]()
$390
This eDestinos deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:32 am -
3 stops27h 53m
Deal found 8/23![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:40 pm -
3 stops43h 45m
Deal found 8/23![Multiple Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/278:43 am -
2 stops17h 00m
Deal found 8/21![Multiple Airlines logo]()
$559
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:43 pm -
1 stop18h 32m
Deal found 8/25![Delta logo]()
$649
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated August 26, 2026.
Round-trip from | $721 (Kiwi.com) |
|---|---|
One-way from | $304 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Tue 9/15
9:40 pm-1:55 pm
2 stops39h 15m
Santiago Arturo Merino Benitez
Tue 9/29
6:00 am-1:55 pm
2 stops32h 55m
$911
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Mon 1/11
1:15 pm-6:55 am
1 stop15h 40m
Santiago Arturo Merino Benitez
Wed 1/20
8:13 am-11:53 pm
2 stops17h 40m
$954
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Wed 10/28
2:05 pm-3:00 pm
2 stops23h 55m
Santiago Arturo Merino Benitez
Sun 11/1
4:05 pm-5:24 pm
2 stops27h 19m
$965
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Wed 10/28
5:00 pm-7:50 am
1 stop13h 50m
Santiago Arturo Merino Benitez
Sun 11/1
10:45 pm-4:19 pm
1 stop19h 34m
$985
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 12/9
6:30 am-8:50 am
2 stops24h 20m
Santiago Arturo Merino Benitez
Mon 2/22
10:45 pm-11:19 pm
2 stops26h 34m
$990
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 10/29
5:50 am-7:50 am
2 stops25h 00m
Santiago Arturo Merino Benitez
Mon 11/2
10:45 pm-4:56 pm
2 stops20h 11m
$990
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 12/3
6:00 am-6:55 am
1 stop22h 55m
Santiago Arturo Merino Benitez
Thu 12/24
9:50 pm-10:33 am
1 stop14h 43m
$1,015
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 10/29
11:45 am-7:40 am
1 stop18h 55m
Santiago Arturo Merino Benitez
Mon 11/2
11:10 pm-6:57 pm
1 stop21h 47m
$1,015
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Wed 12/9
8:05 am-6:40 am
1 stop20h 35m
Santiago Arturo Merino Benitez
Thu 2/25
11:50 pm-10:16 pm
1 stop24h 26m
$1,044
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Mon 11/30
9:47 am-7:15 am
2 stops19h 28m
Santiago Arturo Merino Benitez
Tue 12/8
11:10 pm-11:13 am
1 stop14h 03m
$1,044
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
GSP-SCL
MYR-SCL
CHS-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
GSP-SCL
MYR-SCL
CHS-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on August 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 26, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |