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$285+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Feb 21 — Feb 281
Sat 2/21
Sat 2/28
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:00 am
CLT
-
SCL
2 stops38h 15m
Multiple Airlines
Mon 3/3011:00 pm
SCL
-
CLT
1 stop14h 19m
Multiple Airlines
Deal found 1/20$575
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/128:56 am
CLT
-
SCL
2 stops39h 13m
Multiple Airlines
Mon 3/238:25 am
SCL
-
CLT
2 stops28h 54m
Multiple Airlines
Deal found 1/20$675
This Avianca Connect deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:30 am
CLT
-
SCL
2 stops21h 45m
Multiple Airlines
Sun 5/3111:55 pm
SCL
-
CLT
2 stops20h 34m
Multiple Airlines
Deal found 1/20$678
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/311:35 am
CLT
-
SCL
2 stops16h 25m
Multiple Airlines
Sun 2/810:35 am
SCL
-
CLT
1 stop33h 01m
Multiple Airlines
Deal found 1/21$715
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:08 pm
CLT
-
SCL
1 stop15h 47m
Multiple Airlines
Fri 4/248:15 pm
SCL
-
CLT
2 stops24h 14m
Multiple Airlines
Deal found 1/20$726
This Avianca Connect deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/96:00 am
CLT
-
SCL
2 stops21h 30m
Multiple Airlines
Thu 2/194:25 pm
SCL
-
CLT
2 stops21h 55m
Multiple Airlines
Deal found 1/20$729
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:15 pm
CLT
-
SCL
1 stop17h 35m
LATAM Airlines
Wed 7/810:55 pm
SCL
-
CLT
1 stop14h 57m
LATAM Airlines
Deal found 1/21$738
This Expedia deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:59 pm
CHS
-
SCL
2 stops23h 46m
LATAM Airlines
Sun 8/234:30 pm
SCL
-
CHS
2 stops31h 27m
LATAM Airlines
Deal found 1/21$760
This FlightHub deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:00 am
CLT
-
SCL
1 stop20h 50m
LATAM Airlines
Sun 6/77:45 pm
SCL
-
CLT
2 stops18h 07m
LATAM Airlines
Deal found 1/22$762
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:06 am
CHS
-
SCL
1 stop20h 24m
American Airlines
Wed 3/1110:15 pm
SCL
-
CHS
1 stop21h 13m
American Airlines
Deal found 1/21$783
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
GSP
-
SCL
2 stops21h 05m
LATAM Airlines
Wed 4/1511:00 pm
SCL
-
GSP
2 stops19h 55m
LATAM Airlines
Deal found 1/21$795
This LATAM Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:20 pm
CHS
-
SCL
3 stops21h 44m
LATAM Airlines
Sun 5/39:10 pm
SCL
-
CHS
2 stops27h 11m
LATAM Airlines
Deal found 1/19$797

Find flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated January 22, 2026.

Round-trip from

$575
(Kiwi.com)

One-way from

$285
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
Search Deals
One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 3/24

7:00 am-10:15 pm

2 stops38h 15m

Santiago Arturo Merino Benitez

Mon 3/30

11:00 pm-12:19 pm

1 stop14h 19m

$575

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Thu 3/12

8:56 am-1:09 am

2 stops39h 13m

Santiago Arturo Merino Benitez

Mon 3/23

8:25 am-12:19 pm

2 stops28h 54m

$675

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 5/1

6:30 am-4:15 am

2 stops21h 45m

Santiago Arturo Merino Benitez

Sun 5/31

11:55 pm-8:29 pm

2 stops20h 34m

$678

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 2/3

11:35 am-6:00 am

2 stops16h 25m

Santiago Arturo Merino Benitez

Sun 2/8

10:35 am-5:36 pm

1 stop33h 01m

$715

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 4/20

3:08 pm-6:55 am

1 stop15h 47m

Santiago Arturo Merino Benitez

Fri 4/24

8:15 pm-8:29 pm

2 stops24h 14m

$726

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 2/9

6:00 am-5:30 am

2 stops21h 30m

Santiago Arturo Merino Benitez

Thu 2/19

4:25 pm-12:20 pm

2 stops21h 55m

$729

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 7/1

1:15 pm-6:50 am

1 stop17h 35m

Santiago Arturo Merino Benitez

Wed 7/8

10:55 pm-1:52 pm

1 stop14h 57m

$738

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 5/29

10:00 am-6:50 am

1 stop20h 50m

Santiago Arturo Merino Benitez

Sun 6/7

7:45 pm-1:52 pm

2 stops18h 07m

$762

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 7/1

6:30 pm-2:05 pm

2 stops19h 35m

Santiago Arturo Merino Benitez

Wed 7/8

10:55 pm-6:18 pm

1 stop19h 23m

$775

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 3/4

11:06 am-9:30 am

1 stop20h 24m

Santiago Arturo Merino Benitez

Wed 3/11

10:15 pm-6:28 pm

1 stop21h 13m

$783

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 33 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 18h 07m. American Airlines provides one of the quickest options available for as low as $820. The distance between South Carolina and Santiago is about 4574 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Greenville - Santiago Arturo Merino Benitez and Myrtle Beach Intl - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Santiago

Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$888FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$562Average$901FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$703Average$845FlexibilityNo cancel feeOn-time71%

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