$336+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Oct 3 — Oct 101
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:32 am -
2 stops34h 00m
Tue 10/611:55 pm -
1 stop15h 00m
Deal found 8/30![Multiple Airlines logo]()
$727
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:40 pm -
2 stops53h 16m
Mon 10/511:55 pm -
1 stop22h 19m
Deal found 9/2![Multiple Airlines logo]()
$773
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
2 stops45h 52m
Tue 10/611:55 pm -
1 stop15h 00m
Deal found 9/3![Multiple Airlines logo]()
$814
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops27h 23m
Thu 10/112:23 pm -
2 stops27h 05m
Deal found 9/1![Multiple Airlines logo]()
$820
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:32 am -
2 stops17h 24m
Tue 9/159:30 am -
2 stops29h 25m
Deal found 8/29![Multiple Airlines logo]()
$822
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/810:18 pm -
2 stops22h 17m
Thu 11/1211:10 pm -
1 stop23h 36m
Deal found 9/1![Multiple Airlines logo]()
$835
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
2 stops45h 52m
Sun 10/411:55 pm -
1 stop22h 19m
Deal found 9/3![Multiple Airlines logo]()
$856
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:32 am -
2 stops17h 24m
Mon 11/211:50 pm -
1 stop25h 21m
Deal found 8/30![Multiple Airlines logo]()
$862
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:16 pm -
1 stop12h 29m
Sun 12/611:45 pm -
1 stop16h 54m
Deal found 8/29![American Airlines logo]()
$955
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:13 am -
2 stops17h 27m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/2![Delta logo]()
$965
This LATAM Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:00 pm -
3 stops23h 00m
Sun 12/67:00 pm -
2 stops18h 50m
Deal found 8/29![LATAM Airlines logo]()
$973
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:12 pm -
1 stop13h 38m
Mon 11/210:45 pm -
1 stop18h 29m
Deal found 9/1![United Airlines logo]()
$985
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
This FlightHub deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2410:00 am -
2 stops17h 20m
Mon 4/267:45 am -
2 stops16h 08m
Deal found 8/31![LATAM Airlines logo]()
$915
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/294:33 pm -
1 stop13h 12m
Mon 2/110:15 pm -
1 stop22h 33m
Deal found 8/29![American Airlines logo]()
$955
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:53 pm -
1 stop17h 32m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/1![Delta logo]()
$965
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:12 pm -
1 stop13h 38m
Mon 11/210:45 pm -
1 stop18h 29m
Deal found 8/31![United Airlines logo]()
$985
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 am -
2 stops19h 38m
Tue 11/1012:15 pm -
2 stops48h 27m
Deal found 8/31![Copa Airlines logo]()
$1,140
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:40 pm -
2 stops16h 05m
Sun 12/611:45 pm -
2 stops19h 13m
Deal found 8/29![American Airlines logo]()
$960
This LATAM Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/243:42 pm -
2 stops24h 18m
Sun 3/74:35 pm -
2 stops28h 14m
Deal found 9/2![LATAM Airlines logo]()
$1,015
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/198:30 am -
2 stops22h 20m
Wed 2/1710:45 pm -
2 stops44h 40m
Deal found 9/2![United Airlines logo]()
$1,019
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/147:16 pm -
2 stops17h 44m
Mon 12/218:25 pm -
2 stops19h 41m
Deal found 9/1![Delta logo]()
$1,044
This LATAM Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:45 am -
1 stop18h 55m
Mon 11/211:10 pm -
1 stop21h 47m
Deal found 9/2![LATAM Airlines logo]()
$1,015
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/101:00 pm -
1 stop16h 45m
Thu 12/1711:45 pm -
1 stop15h 10m
Deal found 9/1![American Airlines logo]()
$1,035
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:00 am -
2 stops20h 30m
Wed 11/116:30 pm -
2 stops18h 44m
Deal found 9/2![Delta logo]()
$1,134
This Expedia deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1912:26 pm -
2 stops16h 34m
Wed 2/175:40 am -
3 stops18h 52m
Deal found 9/2![LATAM Airlines logo]()
$1,058
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/112:02 pm -
1 stop18h 58m
Sun 1/3111:45 pm -
1 stop14h 17m
Deal found 9/2![American Airlines logo]()
$1,085
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:15 pm -
1 stop34h 25m
Thu 11/268:25 pm -
2 stops19h 07m
Deal found 8/29![Delta logo]()
$1,141
This LATAM Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:36 pm -
3 stops19h 44m
Thu 12/178:40 am -
2 stops16h 10m
Deal found 9/1![LATAM Airlines logo]()
$1,060
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am -
1 stop22h 55m
Fri 11/2711:50 pm -
1 stop15h 49m
Deal found 8/29![Delta logo]()
$1,179
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:56 pm -
2 stops37h 54m
Thu 11/1910:45 pm -
2 stops20h 55m
Deal found 8/29![United Airlines logo]()
$1,449
This LATAM Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:46 pm -
1 stop11h 29m
Mon 11/211:50 pm -
1 stop15h 49m
Deal found 8/30![LATAM Airlines logo]()
$1,134
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:01 pm -
1 stop10h 44m
Fri 11/1310:30 pm -
1 stop13h 31m
Deal found 8/31![American Airlines logo]()
$1,421
This LATAM Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:40 am -
2 stops22h 00m
Mon 10/512:05 am -
2 stops19h 56m
Deal found 8/30![LATAM Airlines logo]()
$1,224
This LATAM Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:51 am -
2 stops17h 49m
Mon 11/28:25 pm -
2 stops19h 13m
Deal found 9/2![LATAM Airlines logo]()
$1,243
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated September 3, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated September 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:32 am -
2 stops17h 24m
Tue 9/159:30 am -
2 stops29h 25m
Deal found 8/29![Multiple Airlines logo]()
$822
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
2 stops45h 52m
Tue 10/611:55 pm -
1 stop15h 00m
Deal found 9/3![Multiple Airlines logo]()
$814
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
2 stops45h 52m
Sun 10/411:55 pm -
1 stop22h 19m
Deal found 9/3![Multiple Airlines logo]()
$856
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:40 pm -
2 stops53h 16m
Mon 10/511:55 pm -
1 stop22h 19m
Deal found 9/2![Multiple Airlines logo]()
$773
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops27h 23m
Thu 10/112:23 pm -
2 stops27h 05m
Deal found 9/1![Multiple Airlines logo]()
$820
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:42 pm -
2 stops21h 13m
Wed 10/2812:23 pm -
2 stops27h 44m
Deal found 8/31![Multiple Airlines logo]()
$960
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:32 am -
2 stops34h 00m
Tue 10/611:55 pm -
1 stop15h 00m
Deal found 8/30![Multiple Airlines logo]()
$727
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:13 am -
2 stops17h 27m
Thu 10/811:55 pm -
1 stop22h 17m
Deal found 9/2![Delta logo]()
$965
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:32 am -
2 stops17h 24m
Mon 11/211:50 pm -
1 stop25h 21m
Deal found 8/30![Multiple Airlines logo]()
$862
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 pm -
1 stop13h 50m
Sun 11/110:45 pm -
1 stop19h 34m
Deal found 9/1![United Airlines logo]()
$985
This LATAM Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:40 pm -
2 stops17h 50m
Sun 11/111:10 pm -
1 stop20h 14m
Deal found 9/2![LATAM Airlines logo]()
$995
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:12 pm -
1 stop13h 38m
Mon 11/210:45 pm -
1 stop18h 29m
Deal found 9/1![United Airlines logo]()
$985
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/159:18 am -
2 stops36h 18m
Deal found 8/30![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:13 pm -
2 stops29h 19m
Deal found 9/1![Multiple Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:27 pm -
2 stops32h 28m
Deal found 9/2![Multiple Airlines logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:06 pm -
3 stops35h 29m
Deal found 8/30![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:34 pm -
3 stops37h 22m
Deal found 9/2![Multiple Airlines logo]()
$388
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:53 pm -
3 stops39h 07m
Deal found 9/3![Multiple Airlines logo]()
$522
This SmartFares deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/286:59 pm -
1 stop33h 56m
Deal found 8/29![LATAM Airlines logo]()
$596
This Copa Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
2 stops19h 38m
Deal found 8/30![Copa Airlines logo]()
$604
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/286:19 pm -
2 stops36h 31m
Deal found 8/29![United Airlines logo]()
$608
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/303:43 pm -
3 stops37h 17m
Deal found 9/2![Multiple Airlines logo]()
$631
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:45 am -
2 stops14h 23m
Deal found 8/29![Multiple Airlines logo]()
$641
This Expedia deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:59 pm -
1 stop11h 41m
Deal found 9/3![LATAM Airlines logo]()
$643
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated September 3, 2026.
Round-trip from | $727 (Kiwi.com) |
|---|---|
One-way from | $336 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Wed 2/24
10:00 am-5:20 am
2 stops17h 20m
Santiago Arturo Merino Benitez
Mon 4/26
7:45 am-11:53 pm
2 stops16h 08m
$915
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 1/29
4:33 pm-7:45 am
1 stop13h 12m
Santiago Arturo Merino Benitez
Mon 2/1
10:15 pm-6:48 pm
1 stop22h 33m
$955
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 11/17
2:40 pm-8:45 am
2 stops16h 05m
Santiago Arturo Merino Benitez
Sun 12/6
11:45 pm-4:58 pm
2 stops19h 13m
$960
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Thu 10/1
12:53 pm-7:25 am
1 stop17h 32m
Santiago Arturo Merino Benitez
Thu 10/8
11:55 pm-9:12 pm
1 stop22h 17m
$965
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 10/29
5:12 pm-7:50 am
1 stop13h 38m
Santiago Arturo Merino Benitez
Mon 11/2
10:45 pm-3:14 pm
1 stop18h 29m
$985
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Wed 2/24
3:42 pm-6:00 pm
2 stops24h 18m
Santiago Arturo Merino Benitez
Sun 3/7
4:35 pm-6:49 pm
2 stops28h 14m
$1,015
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 10/29
11:45 am-7:40 am
1 stop18h 55m
Santiago Arturo Merino Benitez
Mon 11/2
11:10 pm-6:57 pm
1 stop21h 47m
$1,015
SavannahSantiago
SAV Savannah/Hilton Head - SCL Santiago Arturo Merino Benitez
SAVSCL
Savannah/Hilton Head
Tue 1/19
8:30 am-8:50 am
2 stops22h 20m
Santiago Arturo Merino Benitez
Wed 2/17
10:45 pm-5:25 pm
2 stops44h 40m
$1,019
SavannahSantiago
SAV Savannah/Hilton Head - SCL Santiago Arturo Merino Benitez
SAVSCL
Savannah/Hilton Head
Thu 12/10
1:00 pm-7:45 am
1 stop16h 45m
Santiago Arturo Merino Benitez
Thu 12/17
11:45 pm-12:55 pm
1 stop15h 10m
$1,035
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Mon 12/14
7:16 pm-3:00 pm
2 stops17h 44m
Santiago Arturo Merino Benitez
Mon 12/21
8:25 pm-2:06 pm
2 stops19h 41m
$1,044
Showing 1-10 of 45 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
GSP-SCL
CHS-SCL
CLT-SCL
MYR-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
GSP-SCL
CHS-SCL
CLT-SCL
MYR-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
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Alternative routes for South Carolina to Santiago
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Complete your trip
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Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on September 3, 2026.
Popular flight searches
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 3, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |