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$390+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$650
(Avianca Connect)
Provider with most accurate pricing for Myrtle Beach Intl-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santiago Arturo Merino Benitez flights.
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From South Carolina to Santiago Arturo Merino Benitez
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Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Avianca Connect deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/296:00 amMYR - SCL
2 stops22h 35mMultiple Airlines
Wed 6/41:55 amSCL - MYR
2 stops19h 10mMultiple Airlines
Deal found 4/29$615
This Avianca Connect deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2811:23 amCLT - SCL
2 stops16h 52mMultiple Airlines
Wed 6/42:30 pmSCL - CLT
2 stops20h 33mMultiple Airlines
Deal found 4/30$650
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/12:30 pmCLT - SCL
1 stop16h 15mLATAM Airlines
Tue 10/1410:50 pmSCL - CLT
1 stop16h 02mLATAM Airlines
Deal found 4/30$750
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:46 pmGSP - SCL
1 stop11h 19mAmerican Airlines
Mon 10/2711:45 pmSCL - GSP
1 stop18h 56mAmerican Airlines
Deal found 4/30$754
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/238:14 pmSAV - SCL
1 stop10h 51mAmerican Airlines
Tue 10/79:55 pmSCL - SAV
2 stops17h 30mAmerican Airlines
Deal found 4/30$758
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:55 pmGSP - SCL
1 stop11h 05mDelta
Sun 10/2612:25 amSCL - GSP
2 stops19h 24mDelta
Deal found 4/30$794
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/19:41 amCLT - SCL
2 stops19h 59mDelta
Mon 7/74:55 pmSCL - CLT
2 stops22h 08mDelta
Deal found 4/29$804
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/276:40 pmCLT - SCL
1 stop12h 25mAmerican Airlines
Mon 12/159:30 pmSCL - CLT
1 stop14h 40mAmerican Airlines
Deal found 4/30$829
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:00 amSAV - SCL
2 stops29h 25mLATAM Airlines
Tue 10/76:30 amSCL - SAV
2 stops18h 29mLATAM Airlines
Deal found 4/30$874
This SmartFares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:59 pmGSP - SCL
2 stops32h 56mLATAM Airlines
Sat 1/1712:25 amSCL - GSP
2 stops22h 57mLATAM Airlines
Deal found 4/30$904
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/293:42 pmMYR - SCL
1 stop15h 18mLATAM Airlines
Thu 6/58:40 pmSCL - MYR
1 stop13h 28mLATAM Airlines
Deal found 4/29$1,066
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/293:42 pmMYR - SCL
1 stop15h 18mDelta
Wed 6/412:30 amSCL - MYR
2 stops23h 29mDelta
Deal found 4/29$1,094

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Thu 5/29

6:00 am-4:35 am

2 stops22h 35m

Santiago Arturo Merino Benitez

Wed 6/4

1:55 am-9:05 pm

2 stops19h 10m

$615

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 5/28

11:23 am-4:15 am

2 stops16h 52m

Santiago Arturo Merino Benitez

Wed 6/4

2:30 pm-11:03 am

2 stops20h 33m

$650

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

7:46 pm-8:05 am

1 stop11h 19m

Santiago Arturo Merino Benitez

Mon 10/27

11:45 pm-5:41 pm

1 stop18h 56m

$754

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Tue 9/23

8:14 pm-8:05 am

1 stop10h 51m

Santiago Arturo Merino Benitez

Tue 10/7

9:55 pm-2:25 pm

2 stops17h 30m

$758

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

7:55 pm-8:00 am

1 stop11h 05m

Santiago Arturo Merino Benitez

Sun 10/26

12:25 am-6:49 pm

2 stops19h 24m

$794

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 7/1

6:01 pm-7:00 am

1 stop12h 59m

Santiago Arturo Merino Benitez

Mon 7/7

10:55 pm-1:23 pm

1 stop14h 28m

$796

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 7/1

9:41 am-5:40 am

2 stops19h 59m

Santiago Arturo Merino Benitez

Mon 7/7

4:55 pm-3:03 pm

2 stops22h 08m

$804

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sun 7/27

6:40 pm-7:05 am

1 stop12h 25m

Santiago Arturo Merino Benitez

Mon 12/15

9:30 pm-10:10 am

1 stop14h 40m

$829

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Mon 9/22

7:00 am-1:25 pm

2 stops29h 25m

Santiago Arturo Merino Benitez

Tue 10/7

9:40 pm-6:44 pm

1 stop22h 04m

$874

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/1

7:55 pm-8:00 am

1 stop11h 05m

Santiago Arturo Merino Benitez

Mon 10/13

12:25 am-6:49 pm

2 stops19h 24m

$914

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 15 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest month to book a flight from South Carolina to Santiago?

Currently, April is the cheapest month in which you can book a flight from South Carolina to Santiago (average of $752). Flying from South Carolina to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South Carolina to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated May 1, 2025.
To help decide which airline to fly from South Carolina to Santiago, see what other customers have to say about Delta, LATAM Airlines and Qantas Airways. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Qantas Airways
7.5
Good
829 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,414 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Savannah/Hilton Head - Santiago Arturo Merino Benitez and Greenville - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santiago?

    Currently, April is the cheapest month in which you can book a flight from South Carolina to Santiago (average of $752). Flying from South Carolina to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$603Average$878FlexibilityNo cancel feeOn-time81%
DeltaCheapest$617Average$942FlexibilityNo cancel feeOn-timeN/A

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