$307+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Aug 1 — Aug 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:58 pm
CLT
- SCL
1 stop16h 57m
Multiple Airlines
Wed 9/23:20 pm
SCL
- CLT
2 stops28h 51m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$803
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:15 am
CHS
- SCL
1 stop25h 00m
Delta
Thu 8/68:40 pm
SCL
- CHS
1 stop13h 40m
Delta
Deal found 7/1![Delta logo]()
$843
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:20 am
CHS
- SCL
2 stops22h 25m
LATAM Airlines
Thu 8/65:40 am
SCL
- CHS
2 stops27h 18m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$852
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:06 pm
CHS
- SCL
1 stop14h 09m
Delta
Mon 8/314:15 am
SCL
- CHS
2 stops19h 44m
Delta
Deal found 6/27![Delta logo]()
$855
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/131:05 pm
CHS
- SCL
1 stop18h 10m
Delta
Thu 7/2311:00 pm
SCL
- CHS
2 stops21h 42m
Delta
Deal found 7/1![Delta logo]()
$860
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:21 pm
CHS
- SCL
1 stop36h 04m
Delta
Wed 9/27:55 pm
SCL
- CHS
2 stops18h 52m
Delta
Deal found 6/27![Delta logo]()
$864
This oojo deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:18 am
CHS
- SCL
2 stops18h 17m
LATAM Airlines
Wed 7/298:30 am
SCL
- CHS
3 stops25h 43m
LATAM Airlines
Deal found 6/28![LATAM Airlines logo]()
$865
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:00 am
CHS
- SCL
1 stop25h 05m
American Airlines
Mon 8/318:50 pm
SCL
- CHS
1 stop26h 08m
American Airlines
Deal found 6/27![American Airlines logo]()
$872
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:10 am
CHS
- SCL
2 stops14h 35m
Delta
Fri 8/78:40 pm
SCL
- CHS
1 stop12h 39m
Delta
Deal found 7/1![Delta logo]()
$873
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:18 am
CHS
- SCL
2 stops18h 27m
LATAM Airlines
Sat 8/87:50 am
SCL
- CHS
2 stops26h 30m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$882
This oojo deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Sun 11/1512:40 pm
SCL
- CLT
2 stops37h 13m
LATAM Airlines
Deal found 6/29![LATAM Airlines logo]()
$883
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 6/27![American Airlines logo]()
$885
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:58 pm
CLT
- SCL
1 stop16h 57m
Multiple Airlines
Wed 9/23:20 pm
SCL
- CLT
2 stops28h 51m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$803
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:47 pm
CHS
- SCL
1 stop17h 38m
Delta
Tue 9/158:40 pm
SCL
- CHS
1 stop14h 26m
Delta
Deal found 6/28![Delta logo]()
$855
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
GSP
- SCL
1 stop23h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 6/27![American Airlines logo]()
$894
This Copa Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Sat 11/143:19 am
SCL
- CLT
2 stops32h 45m
Copa Airlines
Deal found 6/27![Copa Airlines logo]()
$915
This LATAM Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:25 am
GSP
- SCL
3 stops26h 00m
LATAM Airlines
Tue 8/1811:00 pm
SCL
- GSP
2 stops19h 45m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$920
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:25 am
GSP
- SCL
2 stops32h 11m
United Airlines
Tue 8/1811:22 am
SCL
- GSP
2 stops23h 15m
United Airlines
Deal found 6/29![United Airlines logo]()
$1,108
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:17 pm
CHS
- SCL
1 stop16h 58m
Delta
Thu 9/38:40 pm
SCL
- CHS
1 stop15h 14m
Delta
Deal found 6/27![Delta logo]()
$855
This oojo deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:00 pm
GSP
- SCL
2 stops18h 55m
LATAM Airlines
Tue 8/188:30 am
SCL
- GSP
3 stops26h 37m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$922
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:41 am
CHS
- SCL
1 stop21h 34m
Delta
Thu 7/238:40 pm
SCL
- CHS
1 stop22h 14m
Delta
Deal found 6/27![Delta logo]()
$855
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:02 am
MYR
- SCL
2 stops20h 03m
American Airlines
Thu 8/208:50 pm
SCL
- MYR
2 stops22h 01m
American Airlines
Deal found 6/29![American Airlines logo]()
$952
This Copa Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:25 am
CLT
- SCL
2 stops18h 45m
Copa Airlines
Sat 12/512:20 pm
SCL
- CLT
2 stops23h 24m
Copa Airlines
Deal found 7/1![Copa Airlines logo]()
$1,032
This LATAM Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:20 pm
GSP
- SCL
2 stops24h 05m
LATAM Airlines
Tue 8/188:40 pm
SCL
- GSP
1 stop14h 27m
LATAM Airlines
Deal found 6/30![LATAM Airlines logo]()
$945
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:10 pm
CLT
- SCL
2 stops27h 25m
Multiple Airlines
Mon 11/1611:10 pm
SCL
- CLT
2 stops19h 16m
Multiple Airlines
Deal found 7/1![Multiple Airlines logo]()
$1,043
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:21 pm
CHS
- SCL
1 stop36h 04m
Delta
Tue 9/17:55 pm
SCL
- CHS
2 stops21h 43m
Delta
Deal found 6/27![Delta logo]()
$864
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:21 pm
CHS
- SCL
1 stop36h 04m
Delta
Wed 9/27:55 pm
SCL
- CHS
2 stops18h 52m
Delta
Deal found 6/27![Delta logo]()
$864
This Expedia deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:45 am
CLT
- SCL
1 stop17h 55m
LATAM Airlines
Sun 11/1512:55 am
SCL
- CLT
1 stop14h 59m
LATAM Airlines
Deal found 6/29![LATAM Airlines logo]()
$965
This LATAM Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:02 pm
MYR
- SCL
1 stop12h 13m
LATAM Airlines
Tue 8/188:40 pm
SCL
- MYR
1 stop21h 27m
LATAM Airlines
Deal found 6/28![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:18 pm
MYR
- SCL
2 stops23h 47m
Delta
Tue 8/188:40 pm
SCL
- MYR
1 stop14h 07m
Delta
Deal found 6/28![Delta logo]()
$1,027
This LATAM Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:02 pm
MYR
- SCL
1 stop12h 13m
LATAM Airlines
Thu 8/208:40 pm
SCL
- MYR
1 stop21h 27m
LATAM Airlines
Deal found 6/29![LATAM Airlines logo]()
$1,027
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:43 am
MYR
- SCL
2 stops17h 07m
LATAM Airlines
Wed 9/96:45 pm
SCL
- MYR
2 stops22h 59m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:50 am
CLT
- SCL
2 stops19h 05m
Delta
Wed 9/27:50 am
SCL
- CLT
2 stops16h 07m
Delta
Deal found 6/29![Delta logo]()
$1,028
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:11 pm
SAV
- SCL
1 stop16h 04m
Delta
Wed 9/168:40 pm
SCL
- SAV
1 stop15h 54m
Delta
Deal found 6/29![Delta logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:39 pm
SAV
- SCL
2 stops23h 56m
LATAM Airlines
Mon 9/217:50 am
SCL
- SAV
2 stops17h 05m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$1,047
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3112:05 pm
SAV
- SCL
1 stop18h 20m
Delta
Wed 9/97:55 pm
SCL
- SAV
2 stops19h 05m
Delta
Deal found 6/28![Delta logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:02 pm
MYR
- SCL
2 stops22h 23m
LATAM Airlines
Tue 8/2511:15 pm
SCL
- MYR
2 stops18h 52m
LATAM Airlines
Deal found 6/26![LATAM Airlines logo]()
$1,057
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:54 pm
SAV
- SCL
1 stop35h 31m
Delta
Mon 9/1410:55 pm
SCL
- SAV
1 stop23h 44m
Delta
Deal found 6/28![Delta logo]()
$1,057
This oojo deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:15 pm
CLT
- SCL
1 stop34h 10m
LATAM Airlines
Sun 10/189:30 pm
SCL
- CLT
2 stops27h 23m
LATAM Airlines
Deal found 6/30![LATAM Airlines logo]()
$1,124
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:54 pm
SAV
- SCL
1 stop35h 31m
Delta
Wed 9/97:55 pm
SCL
- SAV
2 stops19h 05m
Delta
Deal found 6/28![Delta logo]()
$1,057
This LATAM Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:45 am
GSP
- SCL
2 stops32h 15m
LATAM Airlines
Tue 11/2411:10 pm
SCL
- GSP
1 stop21h 39m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$1,132
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:11 pm
SAV
- SCL
1 stop16h 04m
Delta
Wed 9/168:40 pm
SCL
- SAV
1 stop15h 54m
Delta
Deal found 6/30![Delta logo]()
$1,077
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated July 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated July 2, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:15 am
CHS
- SCL
1 stop25h 00m
Delta
Thu 8/68:40 pm
SCL
- CHS
1 stop13h 40m
Delta
Deal found 7/1![Delta logo]()
$843
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:10 am
CHS
- SCL
2 stops14h 35m
Delta
Thu 7/2311:00 pm
SCL
- CHS
2 stops18h 16m
Delta
Deal found 6/30![Delta logo]()
$860
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:10 am
CHS
- SCL
2 stops14h 35m
Delta
Fri 8/78:40 pm
SCL
- CHS
1 stop12h 39m
Delta
Deal found 7/1![Delta logo]()
$873
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:20 am
CHS
- SCL
2 stops22h 25m
LATAM Airlines
Thu 8/65:40 am
SCL
- CHS
2 stops27h 18m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$852
This oojo deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:18 am
CHS
- SCL
2 stops18h 17m
LATAM Airlines
Wed 7/298:30 am
SCL
- CHS
3 stops25h 43m
LATAM Airlines
Deal found 6/28![LATAM Airlines logo]()
$865
This LATAM Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:18 am
CHS
- SCL
2 stops18h 27m
LATAM Airlines
Sat 8/87:50 am
SCL
- CHS
2 stops26h 30m
LATAM Airlines
Deal found 7/1![LATAM Airlines logo]()
$882
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 6/27![American Airlines logo]()
$885
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:21 pm
CHS
- SCL
1 stop36h 04m
Delta
Wed 9/27:55 pm
SCL
- CHS
2 stops18h 52m
Delta
Deal found 6/27![Delta logo]()
$864
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:00 am
CHS
- SCL
1 stop25h 05m
American Airlines
Mon 8/318:50 pm
SCL
- CHS
1 stop26h 08m
American Airlines
Deal found 6/27![American Airlines logo]()
$872
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:06 pm
CHS
- SCL
1 stop14h 09m
Delta
Mon 8/314:15 am
SCL
- CHS
2 stops19h 44m
Delta
Deal found 6/27![Delta logo]()
$855
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:58 pm
CLT
- SCL
1 stop16h 57m
Multiple Airlines
Wed 9/23:20 pm
SCL
- CLT
2 stops28h 51m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$803
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:00 pm
CHS
- SCL
1 stop16h 15m
Delta
Tue 9/158:40 pm
SCL
- CHS
1 stop13h 06m
Delta
Deal found 6/28![Delta logo]()
$885
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:13 pm
MYR
- SCL
2 stops34h 47m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$307
This Trip.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:52 pm
CLT
- SCL
2 stops29h 08m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:45 pm
GSP
- SCL
2 stops50h 41m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:56 am
CLT
- SCL
2 stops18h 00m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:42 pm
MYR
- SCL
2 stops36h 18m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:24 pm
CLT
- SCL
2 stops35h 02m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:43 pm
CLT
- SCL
2 stops29h 17m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:08 pm
CLT
- SCL
3 stops28h 52m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:02 pm
CLT
- SCL
2 stops27h 24m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:07 am
GSP
- SCL
2 stops14h 43m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/222:13 pm
CHS
- SCL
2 stops34h 35m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:40 pm
GSP
- SCL
2 stops31h 03m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$410
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 2, 2026.
Round-trip from | $803 (Kiwi.com) |
|---|---|
One-way from | $307 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 8/20
1:58 pm-6:55 am
1 stop16h 57m
Santiago Arturo Merino Benitez
Wed 9/2
3:20 pm-8:11 pm
2 stops28h 51m
$803
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 9/2
12:47 pm-6:25 am
1 stop17h 38m
Santiago Arturo Merino Benitez
Tue 9/15
8:40 pm-10:06 am
1 stop14h 26m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 8/17
2:17 pm-7:15 am
1 stop16h 58m
Santiago Arturo Merino Benitez
Thu 9/3
8:40 pm-11:54 am
1 stop15h 14m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
9:41 am-7:15 am
1 stop21h 34m
Santiago Arturo Merino Benitez
Thu 7/23
8:40 pm-6:54 pm
1 stop22h 14m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sun 8/16
6:21 pm-6:25 am
1 stop36h 04m
Santiago Arturo Merino Benitez
Tue 9/1
7:55 pm-5:38 pm
2 stops21h 43m
$864
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sun 8/16
6:21 pm-6:25 am
1 stop36h 04m
Santiago Arturo Merino Benitez
Wed 9/2
7:55 pm-2:47 pm
2 stops18h 52m
$864
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 8/11
7:00 am-6:25 am
1 stop23h 25m
Santiago Arturo Merino Benitez
Tue 8/18
8:50 pm-6:10 pm
1 stop21h 20m
$894
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 11/7
6:00 am-5:46 am
2 stops21h 46m
Santiago Arturo Merino Benitez
Sat 11/14
3:19 am-10:04 am
2 stops32h 45m
$915
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 8/13
11:25 am-1:25 pm
3 stops26h 00m
Santiago Arturo Merino Benitez
Tue 8/18
11:00 pm-6:45 pm
2 stops19h 45m
$920
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 8/11
12:00 pm-6:55 am
2 stops18h 55m
Santiago Arturo Merino Benitez
Tue 8/18
8:30 am-11:07 am
3 stops26h 37m
$922
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
MYR-SCL
CLT-SCL
GSP-SCL
CHS-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
MYR-SCL
CLT-SCL
GSP-SCL
CHS-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on July 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 2, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |