$351+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Sep 19 — Sep 261
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:56 am -
2 stops20h 59m
Wed 8/2611:00 pm -
1 stop17h 46m
Deal found 8/17![Multiple Airlines logo]()
$800
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops16h 14m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/15![Multiple Airlines logo]()
$805
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:32 am -
2 stops34h 00m
Thu 10/1511:55 pm -
1 stop22h 01m
Deal found 8/19![Multiple Airlines logo]()
$815
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops20h 59m
Wed 9/28:30 am -
2 stops32h 16m
Deal found 8/16![Multiple Airlines logo]()
$885
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 am -
2 stops28h 39m
Wed 9/212:35 am -
1 stop16h 11m
Deal found 8/18![Multiple Airlines logo]()
$920
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops20h 59m
Sun 8/3012:35 am -
1 stop16h 11m
Deal found 8/15![Multiple Airlines logo]()
$929
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:56 am -
2 stops20h 59m
Wed 8/2611:00 pm -
1 stop17h 46m
Deal found 8/18![Multiple Airlines logo]()
$934
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:41 am -
1 stop19h 19m
Tue 11/2410:15 pm -
1 stop14h 40m
Deal found 8/16![American Airlines logo]()
$955
This Copa Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:55 pm -
2 stops22h 20m
Mon 11/301:07 am -
2 stops34h 37m
Deal found 8/16![Copa Airlines logo]()
$958
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:00 am -
1 stop21h 40m
Mon 1/1110:15 am -
2 stops15h 38m
Deal found 8/19![Delta logo]()
$959
This LATAM Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:12 pm -
3 stops21h 13m
Tue 9/228:55 pm -
2 stops15h 43m
Deal found 8/18![LATAM Airlines logo]()
$970
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:49 am -
1 stop24h 01m
Tue 2/910:45 pm -
1 stop18h 33m
Deal found 8/17![United Airlines logo]()
$985
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/131:15 pm -
1 stop15h 35m
Mon 1/2511:55 pm -
1 stop15h 59m
Deal found 8/17![Delta logo]()
$954
This LATAM Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/411:45 am -
2 stops26h 03m
Mon 1/117:05 pm -
2 stops20h 49m
Deal found 8/15![LATAM Airlines logo]()
$954
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:41 am -
1 stop19h 19m
Tue 11/2410:15 pm -
1 stop14h 40m
Deal found 8/19![American Airlines logo]()
$955
This Copa Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:55 pm -
2 stops22h 20m
Mon 11/301:07 am -
2 stops34h 37m
Deal found 8/16![Copa Airlines logo]()
$958
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/146:30 am -
2 stops24h 20m
Wed 1/2010:45 pm -
2 stops17h 25m
Deal found 8/17![United Airlines logo]()
$990
This LATAM Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:07 am -
2 stops18h 53m
Mon 1/1110:15 am -
2 stops15h 38m
Deal found 8/19![LATAM Airlines logo]()
$959
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:00 am -
1 stop21h 40m
Mon 1/1110:15 am -
2 stops15h 38m
Deal found 8/19![Delta logo]()
$959
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/152:08 pm -
2 stops16h 17m
Tue 9/229:30 pm -
2 stops20h 20m
Deal found 8/18![American Airlines logo]()
$960
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/145:15 pm -
1 stop13h 35m
Tue 1/2610:45 pm -
2 stops26h 34m
Deal found 8/17![United Airlines logo]()
$990
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:47 pm -
2 stops36h 03m
Sun 11/810:45 pm -
2 stops17h 43m
Deal found 8/18![United Airlines logo]()
$990
This LATAM Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:05 am -
3 stops26h 36m
Wed 12/911:10 pm -
1 stop14h 37m
Deal found 8/16![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/163:30 pm -
1 stop14h 10m
Mon 1/2511:55 pm -
1 stop15h 59m
Deal found 8/17![Delta logo]()
$999
This Copa Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:25 am -
2 stops36h 14m
Sat 10/315:15 am -
2 stops31h 27m
Deal found 8/16![Copa Airlines logo]()
$1,138
This oojo deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/92:04 pm -
2 stops14h 56m
Tue 11/248:35 am -
3 stops27h 38m
Deal found 8/16![LATAM Airlines logo]()
$997
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/411:00 am -
1 stop18h 45m
Mon 1/1111:45 pm -
1 stop18h 34m
Deal found 8/15![American Airlines logo]()
$1,104
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:40 pm -
2 stops35h 10m
Wed 12/910:45 pm -
2 stops45h 00m
Deal found 8/18![United Airlines logo]()
$1,009
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/166:00 am -
1 stop22h 50m
Tue 1/2611:55 pm -
1 stop19h 15m
Deal found 8/17![Delta logo]()
$1,045
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:00 pm -
1 stop13h 00m
Mon 1/1111:45 pm -
1 stop21h 04m
Deal found 8/19![American Airlines logo]()
$1,104
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:15 pm -
1 stop13h 35m
Mon 1/2510:45 pm -
2 stops20h 15m
Deal found 8/17![United Airlines logo]()
$1,020
This Expedia deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:00 pm -
1 stop16h 40m
Sat 1/235:55 pm -
2 stops31h 42m
Deal found 8/18![LATAM Airlines logo]()
$1,039
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:00 pm -
1 stop17h 40m
Sat 1/2311:00 pm -
1 stop17h 49m
Deal found 8/19![Delta logo]()
$1,045
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:20 am -
2 stops48h 30m
Sun 11/810:45 pm -
1 stop19h 43m
Deal found 8/16![United Airlines logo]()
$1,038
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/153:42 pm -
1 stop12h 58m
Thu 1/2111:00 pm -
1 stop12h 25m
Deal found 8/17![Delta logo]()
$1,045
This LATAM Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:10 pm -
3 stops20h 50m
Sun 3/1411:10 pm -
2 stops19h 33m
Deal found 8/19![LATAM Airlines logo]()
$1,070
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:00 am -
1 stop23h 50m
Mon 12/1410:45 pm -
1 stop16h 15m
Deal found 8/17![United Airlines logo]()
$1,047
This LATAM Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:00 pm -
1 stop14h 15m
Sat 10/178:40 pm -
1 stop15h 20m
Deal found 8/19![LATAM Airlines logo]()
$1,075
This LATAM Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:01 pm -
2 stops20h 59m
Mon 12/78:25 pm -
2 stops15h 42m
Deal found 8/16![LATAM Airlines logo]()
$1,077
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:25 am -
2 stops22h 45m
Thu 10/85:15 am -
2 stops41h 07m
Deal found 8/17![United Airlines logo]()
$1,179
This Cheapflightsfares deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:23 pm -
1 stop16h 02m
Tue 9/2911:55 pm -
1 stop14h 47m
Deal found 8/19![LATAM Airlines logo]()
$1,218
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:56 pm -
2 stops37h 54m
Thu 11/1910:45 pm -
1 stop21h 06m
Deal found 8/19![United Airlines logo]()
$1,449
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated August 20, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated August 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:56 am -
2 stops20h 59m
Sun 8/238:30 am -
2 stops32h 16m
Deal found 8/17![Multiple Airlines logo]()
$979
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:56 am -
2 stops20h 59m
Wed 8/2611:00 pm -
1 stop17h 46m
Deal found 8/18![Multiple Airlines logo]()
$934
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops20h 59m
Wed 9/28:30 am -
2 stops32h 16m
Deal found 8/16![Multiple Airlines logo]()
$885
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:56 am -
2 stops20h 59m
Sun 8/3012:35 am -
1 stop16h 11m
Deal found 8/15![Multiple Airlines logo]()
$929
This LATAM Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:17 pm -
2 stops29h 28m
Tue 9/18:40 pm -
1 stop13h 28m
Deal found 8/15![LATAM Airlines logo]()
$1,342
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:56 am -
2 stops28h 39m
Wed 9/212:35 am -
1 stop16h 11m
Deal found 8/18![Multiple Airlines logo]()
$920
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:30 pm -
1 stop13h 55m
Tue 9/229:30 pm -
1 stop19h 04m
Deal found 8/18![American Airlines logo]()
$955
This LATAM Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:12 pm -
3 stops21h 13m
Tue 9/228:55 pm -
2 stops15h 43m
Deal found 8/18![LATAM Airlines logo]()
$970
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:32 am -
2 stops16h 14m
Tue 9/2911:55 pm -
1 stop15h 00m
Deal found 8/15![Multiple Airlines logo]()
$805
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:23 pm -
2 stops14h 37m
Wed 9/309:30 pm -
2 stops20h 25m
Deal found 8/19![American Airlines logo]()
$1,312
This Cheapflightsfares deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:56 pm -
2 stops25h 29m
Wed 9/308:40 pm -
1 stop14h 27m
Deal found 8/19![LATAM Airlines logo]()
$1,315
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
3 stops23h 15m
Deal found 8/15![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:27 pm -
3 stops36h 08m
Deal found 8/19![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:06 pm -
3 stops35h 29m
Deal found 8/19![Multiple Airlines logo]()
$373
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:10 pm -
2 stops24h 48m
Deal found 8/15![Multiple Airlines logo]()
$525
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/304:36 pm -
3 stops32h 59m
Deal found 8/15![Multiple Airlines logo]()
$547
This Expedia deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1911:45 am -
1 stop16h 55m
Deal found 8/15![LATAM Airlines logo]()
$595
This Cheapflightsfares deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:30 pm -
1 stop14h 20m
Deal found 8/15![LATAM Airlines logo]()
$600
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1010:40 am -
1 stop18h 10m
Deal found 8/16![Delta logo]()
$602
This Expedia deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:11 pm -
1 stop13h 29m
Deal found 8/15![LATAM Airlines logo]()
$640
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:00 pm -
1 stop13h 50m
Deal found 8/19![United Airlines logo]()
$644
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:01 pm -
1 stop10h 59m
Deal found 8/15![American Airlines logo]()
$691
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:25 pm -
2 stops37h 25m
Deal found 8/17![United Airlines logo]()
$693
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated August 20, 2026.
Round-trip from | $805 (Kiwi.com) |
|---|---|
One-way from | $351 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Wed 1/13
1:15 pm-6:50 am
1 stop15h 35m
Santiago Arturo Merino Benitez
Mon 1/25
11:55 pm-1:54 pm
1 stop15h 59m
$954
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Mon 1/4
11:45 am-3:48 pm
2 stops26h 03m
Santiago Arturo Merino Benitez
Mon 1/11
7:05 pm-1:54 pm
2 stops20h 49m
$954
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Mon 11/9
11:41 am-9:00 am
1 stop19h 19m
Santiago Arturo Merino Benitez
Tue 11/24
10:15 pm-10:55 am
1 stop14h 40m
$955
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Tue 11/17
7:55 pm-8:15 pm
2 stops22h 20m
Santiago Arturo Merino Benitez
Mon 11/30
1:07 am-9:44 am
2 stops34h 37m
$958
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Tue 12/29
10:07 am-7:00 am
2 stops18h 53m
Santiago Arturo Merino Benitez
Mon 1/11
10:15 am-11:53 pm
2 stops15h 38m
$959
CharlotteSantiago
CLT Charlotte Douglas - SCL Santiago Arturo Merino Benitez
CLTSCL
Charlotte Douglas
Tue 12/29
8:00 am-7:40 am
1 stop21h 40m
Santiago Arturo Merino Benitez
Mon 1/11
10:15 am-11:53 pm
2 stops15h 38m
$959
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Tue 9/15
2:08 pm-7:25 am
2 stops16h 17m
Santiago Arturo Merino Benitez
Tue 9/22
9:30 pm-4:50 pm
2 stops20h 20m
$960
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 1/14
6:30 am-8:50 am
2 stops24h 20m
Santiago Arturo Merino Benitez
Wed 1/20
10:45 pm-2:10 pm
2 stops17h 25m
$990
GreenvilleSantiago
GSP Greenville - SCL Santiago Arturo Merino Benitez
GSPSCL
Greenville
Thu 1/14
5:15 pm-8:50 am
1 stop13h 35m
Santiago Arturo Merino Benitez
Tue 1/26
10:45 pm-11:19 pm
2 stops26h 34m
$990
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Sun 11/1
6:47 pm-8:50 am
2 stops36h 03m
Santiago Arturo Merino Benitez
Sun 11/8
10:45 pm-2:28 pm
2 stops17h 43m
$990
Showing 1-10 of 42 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
MYR-SCL
GSP-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on August 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 20, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |