$336+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jun 23 — Jun 301
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:48 pm
CLT
- SCL
2 stops34h 47m
Multiple Airlines
Mon 8/3111:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$708
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:48 pm
CLT
- SCL
2 stops31h 47m
Multiple Airlines
Mon 8/2411:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$726
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:24 pm
CLT
- SCL
2 stops16h 50m
Multiple Airlines
Mon 8/2411:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$735
This KAYAK deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Wed 10/2110:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$780
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/48:02 pm
CLT
- SCL
2 stops29h 48m
Multiple Airlines
Tue 8/1811:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$783
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:48 pm
CLT
- SCL
2 stops42h 47m
Multiple Airlines
Tue 8/2511:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$789
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:02 pm
CLT
- SCL
2 stops30h 18m
Multiple Airlines
Sun 8/2311:00 pm
SCL
- CLT
1 stop18h 14m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$798
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:02 pm
CLT
- SCL
2 stops30h 18m
Multiple Airlines
Fri 8/1411:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$801
This LATAM Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:45 am
CLT
- SCL
2 stops21h 50m
LATAM Airlines
Tue 10/2710:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$804
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:08 pm
CHS
- SCL
1 stop11h 52m
American Airlines
Wed 11/410:15 pm
SCL
- CHS
1 stop12h 26m
American Airlines
Deal found 5/22![American Airlines logo]()
$875
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:05 am
CHS
- SCL
2 stops24h 45m
United Airlines
Wed 11/410:45 pm
SCL
- CHS
2 stops22h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$880
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:15 pm
CHS
- SCL
3 stops20h 49m
LATAM Airlines
Wed 11/47:45 am
SCL
- CHS
2 stops18h 11m
LATAM Airlines
Deal found 5/22![LATAM Airlines logo]()
$885
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
This KAYAK deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Wed 10/2110:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$780
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:02 pm
CLT
- SCL
2 stops30h 18m
Multiple Airlines
Fri 8/1411:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$801
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:05 am
CHS
- SCL
2 stops24h 45m
United Airlines
Wed 11/410:45 pm
SCL
- CHS
2 stops22h 14m
United Airlines
Deal found 5/22![United Airlines logo]()
$880
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:40 pm
CLT
- SCL
2 stops14h 10m
American Airlines
Tue 9/229:30 pm
SCL
- CLT
2 stops17h 03m
American Airlines
Deal found 5/23![American Airlines logo]()
$904
This Copa Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:55 pm
CLT
- SCL
2 stops27h 27m
Copa Airlines
Thu 9/241:43 am
SCL
- CLT
2 stops33h 06m
Copa Airlines
Deal found 5/19![Copa Airlines logo]()
$938
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:20 am
CHS
- SCL
2 stops20h 30m
Delta
Thu 7/237:55 pm
SCL
- CHS
2 stops22h 59m
Delta
Deal found 5/19![Delta logo]()
$1,085
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:56 pm
CLT
- SCL
1 stop12h 59m
Multiple Airlines
Tue 9/229:20 pm
SCL
- CLT
2 stops43h 45m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$831
This KAYAK deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:49 pm
CLT
- SCL
1 stop16h 36m
LATAM Airlines
Tue 8/2510:55 pm
SCL
- CLT
1 stop19h 56m
LATAM Airlines
Deal found 5/19![LATAM Airlines logo]()
$942
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:27 pm
SAV
- SCL
1 stop14h 23m
American Airlines
Wed 9/309:30 pm
SCL
- SAV
1 stop18h 39m
American Airlines
Deal found 5/20![American Airlines logo]()
$975
This LATAM Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/82:20 pm
CLT
- SCL
3 stops22h 05m
LATAM Airlines
Tue 9/2211:00 pm
SCL
- CLT
2 stops20h 17m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$949
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:27 pm
SAV
- SCL
1 stop14h 23m
American Airlines
Fri 9/259:30 pm
SCL
- SAV
1 stop18h 39m
American Airlines
Deal found 5/20![American Airlines logo]()
$1,025
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:20 pm
CLT
- SCL
1 stop31h 15m
Multiple Airlines
Mon 6/2212:55 am
SCL
- CLT
3 stops32h 21m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$1,050
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:50 pm
SAV
- SCL
2 stops17h 15m
Delta
Fri 9/2510:55 pm
SCL
- SAV
1 stop19h 03m
Delta
Deal found 5/22![Delta logo]()
$1,155
This LATAM Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:05 pm
GSP
- SCL
2 stops23h 25m
LATAM Airlines
Mon 11/211:05 pm
SCL
- GSP
2 stops26h 32m
LATAM Airlines
Deal found 5/21![LATAM Airlines logo]()
$966
This KAYAK deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:40 pm
GSP
- SCL
2 stops27h 46m
Copa Airlines
Tue 6/911:17 am
SCL
- GSP
2 stops22h 38m
Copa Airlines
Deal found 5/21![Copa Airlines logo]()
$1,238
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:15 pm
GSP
- SCL
1 stop13h 35m
United Airlines
Mon 11/210:45 pm
SCL
- GSP
1 stop18h 33m
United Airlines
Deal found 5/21![United Airlines logo]()
$1,245
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:02 pm
CLT
- SCL
2 stops47h 34m
Multiple Airlines
Sun 7/1911:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$1,067
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1311:04 am
CHS
- SCL
1 stop19h 56m
American Airlines
Thu 7/239:00 pm
SCL
- CHS
1 stop13h 22m
American Airlines
Deal found 5/19![American Airlines logo]()
$1,075
This United Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:45 am
SAV
- SCL
1 stop19h 05m
United Airlines
Sun 11/110:45 pm
SCL
- SAV
2 stops24h 25m
United Airlines
Deal found 5/19![United Airlines logo]()
$1,290
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:57 pm
MYR
- SCL
2 stops18h 08m
Delta
Wed 7/158:40 pm
SCL
- MYR
1 stop14h 07m
Delta
Deal found 5/20![Delta logo]()
$1,305
This Orbitz deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:50 pm
SAV
- SCL
2 stops14h 05m
LATAM Airlines
Wed 9/309:30 am
SCL
- SAV
3 stops26h 50m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$1,141
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:59 pm
CHS
- SCL
1 stop11h 01m
American Airlines
Wed 11/1110:15 pm
SCL
- CHS
1 stop12h 26m
American Airlines
Deal found 5/21![American Airlines logo]()
$1,195
This LATAM Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 pm
MYR
- SCL
2 stops20h 45m
LATAM Airlines
Mon 11/1611:05 pm
SCL
- MYR
2 stops20h 50m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$1,160
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/611:19 am
MYR
- SCL
2 stops19h 41m
American Airlines
Wed 7/159:00 pm
SCL
- MYR
2 stops18h 31m
American Airlines
Deal found 5/20![American Airlines logo]()
$1,230
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:15 pm
CHS
- SCL
2 stops16h 45m
LATAM Airlines
Sun 11/111:25 pm
SCL
- CHS
2 stops26h 31m
LATAM Airlines
Deal found 5/22![LATAM Airlines logo]()
$1,205
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:56 am
SAV
- SCL
2 stops20h 09m
American Airlines
Mon 6/229:00 pm
SCL
- SAV
2 stops23h 42m
American Airlines
Deal found 5/19![American Airlines logo]()
$1,250
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:15 am
GSP
- SCL
2 stops19h 50m
American Airlines
Thu 7/29:00 pm
SCL
- GSP
2 stops17h 04m
American Airlines
Deal found 5/23![American Airlines logo]()
$1,280
This Cheapflightsfares deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:46 pm
MYR
- SCL
1 stop14h 29m
LATAM Airlines
Wed 7/158:40 pm
SCL
- MYR
1 stop16h 20m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$1,294
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated May 24, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated May 24, 2026 and is based on user searches.
This KAYAK deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:40 pm
GSP
- SCL
2 stops27h 46m
Copa Airlines
Tue 6/911:17 am
SCL
- GSP
2 stops22h 38m
Copa Airlines
Deal found 5/21![Copa Airlines logo]()
$1,238
This KAYAK deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/109:57 am
CLT
- SCL
1 stop20h 28m
LATAM Airlines
Wed 6/177:50 am
SCL
- CLT
2 stops16h 09m
LATAM Airlines
Deal found 5/21![LATAM Airlines logo]()
$1,159
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:29 pm
CLT
- SCL
2 stops16h 34m
Multiple Airlines
Tue 6/2310:30 am
SCL
- CLT
1 stop22h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$895
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:13 pm
CHS
- SCL
2 stops35h 47m
Multiple Airlines
Tue 6/2311:25 pm
SCL
- CHS
1 stop21h 14m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$1,008
This LATAM Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:50 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Tue 6/2311:05 pm
SCL
- CLT
1 stop19h 41m
LATAM Airlines
Deal found 5/19![LATAM Airlines logo]()
$1,023
This KAYAK deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:18 am
CHS
- SCL
2 stops17h 45m
Copa Airlines
Mon 6/222:22 am
SCL
- CHS
2 stops32h 13m
Copa Airlines
Deal found 5/20![Copa Airlines logo]()
$1,166
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:34 pm
CHS
- SCL
1 stop11h 31m
American Airlines
Tue 6/239:00 pm
SCL
- CHS
1 stop22h 29m
American Airlines
Deal found 5/20![American Airlines logo]()
$1,235
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/177:58 pm
CLT
- SCL
2 stops31h 02m
Multiple Airlines
Wed 6/2410:30 am
SCL
- CLT
1 stop30h 44m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$900
This LATAM Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1712:19 pm
CLT
- SCL
3 stops22h 30m
LATAM Airlines
Wed 6/2411:05 pm
SCL
- CLT
2 stops19h 14m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$1,124
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:29 pm
CLT
- SCL
2 stops16h 34m
Multiple Airlines
Thu 6/258:30 am
SCL
- CLT
2 stops32h 44m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$995
This LATAM Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:19 pm
CLT
- SCL
3 stops22h 30m
LATAM Airlines
Thu 6/256:00 pm
SCL
- CLT
3 stops24h 19m
LATAM Airlines
Deal found 5/21![LATAM Airlines logo]()
$1,174
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/221:11 pm
CHS
- SCL
1 stop18h 04m
LATAM Airlines
Sun 6/2811:05 pm
SCL
- CHS
2 stops18h 34m
LATAM Airlines
Deal found 5/22![LATAM Airlines logo]()
$1,205
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:31 pm
CLT
- SCL
2 stops34h 04m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:24 pm
CLT
- SCL
2 stops16h 50m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:10 pm
CLT
- SCL
3 stops34h 22m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1910:02 pm
CLT
- SCL
2 stops28h 58m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:44 pm
CLT
- SCL
3 stops29h 51m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$448
This KAYAK deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Deal found 5/21![LATAM Airlines logo]()
$501
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Deal found 5/22![LATAM Airlines logo]()
$535
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated May 24, 2026.
Round-trip from | $708 (Kiwi.com) |
|---|---|
One-way from | $336 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 10/6
1:15 pm-6:25 am
1 stop16h 10m
Santiago Arturo Merino Benitez
Wed 10/21
10:55 pm-1:54 pm
1 stop15h 59m
$780
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 8/9
8:02 pm-2:20 am
2 stops30h 18m
Santiago Arturo Merino Benitez
Fri 8/14
11:00 pm-5:12 pm
1 stop18h 12m
$801
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 9/8
4:56 pm-6:55 am
1 stop12h 59m
Santiago Arturo Merino Benitez
Tue 9/22
9:20 pm-4:05 pm
2 stops43h 45m
$831
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 10/28
6:05 am-7:50 am
2 stops24h 45m
Santiago Arturo Merino Benitez
Wed 11/4
10:45 pm-6:59 pm
2 stops22h 14m
$880
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 9/8
4:40 pm-7:50 am
2 stops14h 10m
Santiago Arturo Merino Benitez
Tue 9/22
9:30 pm-1:33 pm
2 stops17h 03m
$904
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 9/5
7:55 pm-11:22 pm
2 stops27h 27m
Santiago Arturo Merino Benitez
Thu 9/24
1:43 am-9:49 am
2 stops33h 06m
$938
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/11
1:49 pm-6:25 am
1 stop16h 36m
Santiago Arturo Merino Benitez
Tue 8/25
10:55 pm-6:51 pm
1 stop19h 56m
$942
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 9/8
2:20 pm-1:25 pm
3 stops22h 05m
Santiago Arturo Merino Benitez
Tue 9/22
11:00 pm-6:17 pm
2 stops20h 17m
$949
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 10/29
5:05 pm-5:30 pm
2 stops23h 25m
Santiago Arturo Merino Benitez
Mon 11/2
11:05 pm-11:37 pm
2 stops26h 32m
$966
SavannahSantiago
SAV - SCL
SAVSCL
Savannah/Hilton Head
Mon 9/14
5:27 pm-8:50 am
1 stop14h 23m
Santiago Arturo Merino Benitez
Wed 9/30
9:30 pm-3:09 pm
1 stop18h 39m
$975
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on May 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 24, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |