$295+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
May 21 — May 281
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This eDestinos deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:58 pm
CLT
- SCL
3 stops34h 57m
Multiple Airlines
Tue 5/198:20 pm
SCL
- CLT
2 stops44h 53m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$696
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Wed 7/158:20 pm
SCL
- CLT
3 stops19h 51m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$705
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops21h 25m
Multiple Airlines
Wed 4/296:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$712
This Mytrip deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Mon 6/13:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$720
This Mytrip deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:00 am
CLT
- SCL
3 stops35h 11m
Multiple Airlines
Mon 6/83:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$737
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:06 pm
CLT
- SCL
3 stops43h 24m
Multiple Airlines
Sun 6/73:20 pm
SCL
- CLT
2 stops28h 42m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$749
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:56 pm
CLT
- SCL
1 stop12h 39m
Multiple Airlines
Tue 9/13:35 am
SCL
- CLT
2 stops33h 55m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$755
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Wed 6/36:40 am
SCL
- CLT
2 stops29h 03m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$760
This Mytrip deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:39 pm
MYR
- SCL
3 stops31h 51m
Multiple Airlines
Fri 6/1212:01 am
SCL
- MYR
2 stops33h 13m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$826
This KAYAK deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:55 pm
CHS
- SCL
1 stop13h 20m
LATAM Airlines
Sun 8/2311:05 pm
SCL
- CHS
2 stops34h 38m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:11 pm
CHS
- SCL
1 stop13h 39m
American Airlines
Wed 8/268:30 pm
SCL
- CHS
2 stops21h 20m
American Airlines
Deal found 4/16![American Airlines logo]()
$880
This LATAM Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:30 pm
CHS
- SCL
3 stops20h 55m
LATAM Airlines
Tue 8/2512:40 am
SCL
- CHS
2 stops18h 16m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$930
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This Mytrip deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Mon 6/13:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$720
This FlightHub deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:15 pm
CLT
- SCL
1 stop17h 10m
LATAM Airlines
Thu 9/310:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 4/20![LATAM Airlines logo]()
$801
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:11 pm
CHS
- SCL
1 stop13h 39m
American Airlines
Wed 8/268:30 pm
SCL
- CHS
2 stops21h 20m
American Airlines
Deal found 4/16![American Airlines logo]()
$880
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:09 pm
GSP
- SCL
1 stop18h 06m
Delta
Thu 8/68:40 pm
SCL
- GSP
1 stop15h 33m
Delta
Deal found 4/16![Delta logo]()
$1,115
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
SAV
- SCL
2 stops22h 03m
United Airlines
Wed 8/2611:22 am
SCL
- SAV
2 stops34h 31m
United Airlines
Deal found 4/15![United Airlines logo]()
$1,378
This LATAM Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:00 am
CLT
- SCL
2 stops20h 35m
LATAM Airlines
Thu 10/1510:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 4/19![LATAM Airlines logo]()
$823
This KAYAK deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:55 pm
CHS
- SCL
1 stop13h 20m
LATAM Airlines
Sun 8/2311:05 pm
SCL
- CHS
2 stops34h 38m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$875
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:15 pm
CHS
- SCL
1 stop29h 55m
Multiple Airlines
Sat 6/1311:17 am
SCL
- CHS
2 stops21h 21m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$996
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:54 pm
GSP
- SCL
2 stops18h 11m
American Airlines
Thu 8/68:30 pm
SCL
- GSP
2 stops16h 35m
American Airlines
Deal found 4/16![American Airlines logo]()
$1,030
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:39 pm
CLT
- SCL
1 stop13h 36m
Delta
Thu 7/168:40 pm
SCL
- CLT
1 stop16h 51m
Delta
Deal found 4/15![Delta logo]()
$1,125
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:54 pm
GSP
- SCL
2 stops18h 11m
American Airlines
Tue 6/169:00 pm
SCL
- GSP
2 stops22h 02m
American Airlines
Deal found 4/18![American Airlines logo]()
$1,080
This Cheapflightsfares deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:01 am
CLT
- SCL
2 stops29h 34m
LATAM Airlines
Mon 7/278:40 pm
SCL
- CLT
1 stop14h 46m
LATAM Airlines
Deal found 4/17![LATAM Airlines logo]()
$995
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:39 pm
CLT
- SCL
1 stop13h 36m
Delta
Wed 7/158:40 pm
SCL
- CLT
1 stop14h 46m
Delta
Deal found 4/15![Delta logo]()
$1,175
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:00 pm
GSP
- SCL
2 stops18h 05m
American Airlines
Mon 6/89:00 pm
SCL
- GSP
2 stops17h 18m
American Airlines
Deal found 4/17![American Airlines logo]()
$1,120
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:39 pm
CLT
- SCL
1 stop13h 36m
Delta
Mon 7/138:40 pm
SCL
- CLT
1 stop14h 46m
Delta
Deal found 4/15![Delta logo]()
$1,175
This KAYAK deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:09 pm
GSP
- SCL
3 stops24h 16m
LATAM Airlines
Thu 8/611:00 pm
SCL
- GSP
2 stops24h 54m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$1,112
This FlightHub deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:45 am
CLT
- SCL
1 stop20h 40m
LATAM Airlines
Sun 6/710:55 pm
SCL
- CLT
1 stop19h 51m
LATAM Airlines
Deal found 4/19![LATAM Airlines logo]()
$1,133
This KAYAK deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:35 pm
CHS
- SCL
1 stop14h 40m
LATAM Airlines
Wed 5/134:30 pm
SCL
- CHS
2 stops31h 29m
LATAM Airlines
Deal found 4/18![LATAM Airlines logo]()
$1,217
This KAYAK deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:07 pm
MYR
- SCL
1 stop15h 08m
LATAM Airlines
Sat 6/134:50 pm
SCL
- MYR
2 stops20h 14m
LATAM Airlines
Deal found 4/19![LATAM Airlines logo]()
$1,287
This LATAM Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:02 pm
MYR
- SCL
1 stop12h 13m
LATAM Airlines
Mon 5/48:40 pm
SCL
- MYR
1 stop13h 00m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$1,365
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated April 21, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops21h 25m
Multiple Airlines
Wed 4/296:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$712
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:52 am
MYR
- SCL
3 stops35h 28m
Multiple Airlines
Wed 4/293:20 pm
SCL
- MYR
3 stops32h 09m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$1,070
This LATAM Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:44 pm
CHS
- SCL
1 stop11h 31m
LATAM Airlines
Fri 4/248:40 pm
SCL
- CHS
1 stop13h 29m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$1,425
This eDestinos deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:36 pm
SAV
- SCL
2 stops17h 24m
LATAM Airlines
Thu 4/304:10 am
SCL
- SAV
2 stops19h 49m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$1,424
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Wed 6/36:40 am
SCL
- CLT
2 stops29h 03m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$760
This LATAM Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:26 am
MYR
- SCL
2 stops19h 34m
LATAM Airlines
Mon 5/44:10 am
SCL
- MYR
2 stops20h 04m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$1,365
This eDestinos deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:58 pm
CLT
- SCL
3 stops34h 57m
Multiple Airlines
Tue 5/198:20 pm
SCL
- CLT
2 stops44h 53m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$696
This KAYAK deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:35 pm
CHS
- SCL
1 stop14h 40m
LATAM Airlines
Wed 5/134:30 pm
SCL
- CHS
2 stops31h 29m
LATAM Airlines
Deal found 4/18![LATAM Airlines logo]()
$1,217
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:07 pm
CLT
- SCL
3 stops30h 54m
Multiple Airlines
Sun 5/243:20 pm
SCL
- CLT
2 stops20h 23m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$781
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:12 am
CLT
- SCL
3 stops30h 18m
Multiple Airlines
Wed 7/158:20 pm
SCL
- CLT
3 stops19h 51m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$705
This Mytrip deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Mon 6/13:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$720
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:06 pm
CLT
- SCL
3 stops43h 24m
Multiple Airlines
Sun 6/73:20 pm
SCL
- CLT
2 stops28h 42m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$749
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:45 am
CLT
- SCL
2 stops31h 45m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:45 pm
CLT
- SCL
2 stops44h 45m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:28 pm
GSP
- SCL
3 stops55h 48m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/19:09 pm
SAV
- SCL
3 stops30h 46m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$446
This Cheapflightsfares deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:46 pm
CLT
- SCL
1 stop14h 29m
LATAM Airlines
Deal found 4/17![LATAM Airlines logo]()
$577
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
GSP
- SCL
1 stop25h 05m
American Airlines
Deal found 4/17![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:25 pm
SAV
- SCL
1 stop12h 25m
American Airlines
Deal found 4/17![American Airlines logo]()
$718
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated April 21, 2026.
Round-trip from | $696 (eDestinos) |
|---|---|
One-way from | $295 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 5/27
7:12 am-5:30 am
3 stops22h 18m
Santiago Arturo Merino Benitez
Mon 6/1
3:20 pm-11:40 pm
2 stops32h 20m
$720
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/25
1:15 pm-6:25 am
1 stop17h 10m
Santiago Arturo Merino Benitez
Thu 9/3
10:55 pm-1:52 pm
1 stop14h 57m
$801
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 10/5
8:00 am-5:35 am
2 stops20h 35m
Santiago Arturo Merino Benitez
Thu 10/15
10:55 pm-1:54 pm
1 stop15h 59m
$823
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sat 8/15
5:55 pm-7:15 am
1 stop13h 20m
Santiago Arturo Merino Benitez
Sun 8/23
11:05 pm-9:43 am
2 stops34h 38m
$875
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/13
5:11 pm-6:50 am
1 stop13h 39m
Santiago Arturo Merino Benitez
Wed 8/26
8:30 pm-5:50 pm
2 stops21h 20m
$880
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 7/20
8:01 am-1:35 pm
2 stops29h 34m
Santiago Arturo Merino Benitez
Mon 7/27
8:40 pm-11:26 am
1 stop14h 46m
$995
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sat 6/6
3:15 pm-9:10 pm
1 stop29h 55m
Santiago Arturo Merino Benitez
Sat 6/13
11:17 am-8:38 am
2 stops21h 21m
$996
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 6/25
12:54 pm-7:05 am
2 stops18h 11m
Santiago Arturo Merino Benitez
Thu 8/6
8:30 pm-1:05 pm
2 stops16h 35m
$1,030
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 6/9
12:54 pm-7:05 am
2 stops18h 11m
Santiago Arturo Merino Benitez
Tue 6/16
9:00 pm-7:02 pm
2 stops22h 02m
$1,080
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 6/25
1:09 pm-1:25 pm
3 stops24h 16m
Santiago Arturo Merino Benitez
Thu 8/6
11:00 pm-11:54 pm
2 stops24h 54m
$1,112
Showing 1-10 of 26 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
GSP-SCL
SAV-SCL
MYR-SCL
CHS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
GSP-SCL
SAV-SCL
MYR-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on April 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$753 | Average$948 | FlexibilityNo cancel fee | On-timeN/A |