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$297+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
dic. 26 — ene. 21
vie. 12/26
vie. 1/2
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated noviembre 26, 2025.

Round-trip from

$592
(Mytrip)

One-way from

$297
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
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One-way flight from South Carolina to Santiago Arturo Merino Benitez
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Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 26, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/310:45 amCLT - SCL
2 stops17h 25mMultiple Airlines
sáb. 1/1710:35 amSCL - CLT
1 stop23h 43mMultiple Airlines
Deal found 11/24$683
This Delta deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/65:00 pmCHS - SCL
1 stop12h 40mDelta
mié. 12/1011:10 pmSCL - CHS
1 stop12h 17mDelta
Deal found 11/25$704
This Delta deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/49:51 amCLT - SCL
2 stops18h 44mDelta
mar. 12/98:15 amSCL - CLT
2 stops17h 27mDelta
Deal found 11/24$714
This LATAM Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/22:12 pmCLT - SCL
2 stops14h 48mLATAM Airlines
lun. 1/264:35 amSCL - CLT
2 stops21h 19mLATAM Airlines
Deal found 11/24$719
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:00 pmMYR - SCL
1 stop13h 40mDelta
mié. 12/1011:10 pmSCL - MYR
1 stop12h 37mDelta
Deal found 11/23$754
This LATAM Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/65:10 pmCLT - SCL
1 stop12h 30mLATAM Airlines
mar. 12/94:35 amSCL - CLT
2 stops21h 07mLATAM Airlines
Deal found 11/25$754
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/63:09 pmSAV - SCL
1 stop14h 31mDelta
mié. 12/1011:10 pmSCL - SAV
1 stop12h 33mDelta
Deal found 11/23$754
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/86:50 amGSP - SCL
1 stop24h 00mUnited Airlines
dom. 12/1410:45 pmSCL - GSP
1 stop18h 59mUnited Airlines
Deal found 11/25$754
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/96:00 amGSP - SCL
1 stop23h 45mAmerican Airlines
dom. 12/1411:15 pmSCL - GSP
1 stop18h 19mAmerican Airlines
Deal found 11/25$756
This Mytrip deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/25:35 amCLT - SCL
3 stops20h 25mMultiple Airlines
mar. 1/2712:35 pmSCL - CLT
2 stops24h 23mMultiple Airlines
Deal found 11/24$761
This Ovago deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/211:38 amCLT - SCL
2 stops16h 57mLATAM Airlines
mar. 12/94:35 amSCL - CLT
2 stops21h 07mLATAM Airlines
Deal found 11/24$811
This Expedia deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/103:23 pmGSP - SCL
3 stops21h 07mLATAM Airlines
dom. 12/1410:25 pmSCL - GSP
2 stops26h 08mLATAM Airlines
Deal found 11/25$819

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

sáb. 2/7

9:59 pm-4:55 am

2 stops28h 56m

Santiago Arturo Merino Benitez

mar. 2/17

11:25 pm-12:22 pm

1 stop14h 57m

$648

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

sáb. 2/21

7:00 am-9:59 am

2 stops24h 59m

Santiago Arturo Merino Benitez

dom. 3/8

1:35 am-12:22 pm

3 stops35h 47m

$654

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

jue. 2/5

8:38 pm-10:15 pm

2 stops23h 37m

Santiago Arturo Merino Benitez

mar. 2/17

11:25 pm-12:22 pm

1 stop14h 57m

$660

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 2/9

3:15 pm-10:15 pm

3 stops29h 00m

Santiago Arturo Merino Benitez

vie. 2/20

12:40 am-12:40 am

2 stops26h 00m

$672

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

sáb. 2/7

9:59 pm-4:55 am

2 stops28h 56m

Santiago Arturo Merino Benitez

vie. 2/13

11:25 pm-12:22 pm

1 stop14h 57m

$680

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

jue. 2/5

8:38 pm-10:15 pm

2 stops23h 37m

Santiago Arturo Merino Benitez

dom. 2/15

10:35 am-8:15 am

1 stop23h 40m

$692

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

dom. 2/8

9:19 pm-2:40 pm

2 stops39h 21m

Santiago Arturo Merino Benitez

lun. 2/16

11:25 pm-12:22 pm

1 stop14h 57m

$692

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

jue. 5/7

4:30 pm-6:55 am

2 stops14h 25m

Santiago Arturo Merino Benitez

jue. 5/21

11:00 pm-6:55 pm

2 stops19h 55m

$694

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

vie. 2/6

3:15 pm-10:15 pm

3 stops29h 00m

Santiago Arturo Merino Benitez

dom. 2/15

12:35 pm-12:22 pm

2 stops25h 47m

$698

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

mié. 2/4

7:00 am-8:29 pm

2 stops35h 29m

Santiago Arturo Merino Benitez

mar. 2/17

11:25 pm-12:22 pm

1 stop14h 57m

$698

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 44 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 26, 2025.

One of the essential ways to save on airfare from South Carolina to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 14h 25m. LATAM Airlines provides one of the quickest options available for as low as $694. The distance between South Carolina and Santiago is about 4616 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Greenville - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$888FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$1,002FlexibilityNo cancel feeOn-time81%

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