$377+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 14 — Nov 211
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 15, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 15, 2026.
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:10 pm -
1 stop11h 15m
Wed 2/2411:45 pm -
1 stop16h 59m
Deal found 10/14![American Airlines logo]()
$1,126
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
2 stops24h 50m
Wed 2/2410:45 pm -
1 stop19h 27m
Deal found 10/14![United Airlines logo]()
$1,130
This Expedia deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:34 pm -
1 stop12h 06m
Wed 2/2411:10 pm -
1 stop12h 32m
Deal found 10/14![LATAM Airlines logo]()
$1,131
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:01 am -
2 stops20h 24m
Fri 12/410:30 pm -
2 stops20h 08m
Deal found 10/13![American Airlines logo]()
$1,156
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:49 am -
1 stop24h 01m
Thu 12/310:45 pm -
1 stop18h 32m
Deal found 10/12![United Airlines logo]()
$1,156
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 pm -
1 stop16h 40m
Thu 11/511:10 pm -
1 stop12h 51m
Deal found 10/10![LATAM Airlines logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:00 am -
3 stops25h 20m
Thu 12/311:10 pm -
2 stops21h 10m
Deal found 10/12![LATAM Airlines logo]()
$1,170
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:56 pm -
2 stops34h 54m
Sun 12/2010:45 pm -
2 stops21h 05m
Deal found 10/13![United Airlines logo]()
$1,190
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 pm -
2 stops24h 00m
Tue 11/37:05 pm -
2 stops16h 56m
Deal found 10/10![LATAM Airlines logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:00 pm -
2 stops16h 00m
Thu 11/58:40 am -
2 stops16h 11m
Deal found 10/10![LATAM Airlines logo]()
$1,200
This Cheapflightsfares deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:01 pm -
1 stop13h 39m
Sun 12/2011:00 pm -
1 stop13h 20m
Deal found 10/13![LATAM Airlines logo]()
$1,200
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:52 am -
1 stop19h 23m
Sun 12/2011:20 pm -
1 stop21h 12m
Deal found 10/13![American Airlines logo]()
$1,206
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 15, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 15, 2026.
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1610:55 am -
1 stop18h 45m
Mon 3/19:50 pm -
1 stop14h 18m
Deal found 10/11![Delta logo]()
$1,086
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/412:54 pm -
1 stop17h 21m
Thu 2/2511:45 pm -
1 stop21h 01m
Deal found 10/14![American Airlines logo]()
$1,126
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
2 stops24h 50m
Wed 2/2410:45 pm -
1 stop19h 27m
Deal found 10/14![United Airlines logo]()
$1,130
This LATAM Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/148:08 am -
2 stops20h 52m
Wed 2/245:40 am -
3 stops20h 16m
Deal found 10/14![LATAM Airlines logo]()
$1,150
This KAYAK deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:00 am -
2 stops15h 29m
Sun 3/712:30 pm -
2 stops23h 16m
Deal found 10/14![Copa Airlines logo]()
$1,204
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/156:45 pm -
2 stops18h 10m
Wed 3/38:25 pm -
2 stops15h 43m
Deal found 10/11![Delta logo]()
$1,086
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop23h 15m
Mon 12/1410:30 pm -
1 stop21h 04m
Deal found 10/11![American Airlines logo]()
$1,126
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
2 stops23h 50m
Mon 12/1410:45 pm -
2 stops18h 47m
Deal found 10/11![United Airlines logo]()
$1,130
This Expedia deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/187:55 pm -
2 stops24h 55m
Thu 3/259:50 pm -
1 stop17h 59m
Deal found 10/11![LATAM Airlines logo]()
$1,156
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/1510:55 am -
2 stops18h 35m
Tue 3/28:40 am -
2 stops16h 55m
Deal found 10/11![Delta logo]()
$1,086
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2911:16 am -
2 stops19h 44m
Mon 2/110:15 pm -
2 stops18h 51m
Deal found 10/10![American Airlines logo]()
$1,130
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:49 am -
1 stop24h 01m
Thu 12/310:45 pm -
1 stop18h 32m
Deal found 10/12![United Airlines logo]()
$1,156
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:00 pm -
1 stop12h 40m
Sun 11/84:35 pm -
2 stops27h 39m
Deal found 10/10![LATAM Airlines logo]()
$1,196
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/2110:55 am -
1 stop17h 45m
Wed 3/311:10 pm -
1 stop12h 58m
Deal found 10/11![Delta logo]()
$1,126
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:01 am -
2 stops20h 24m
Fri 12/410:30 pm -
2 stops20h 08m
Deal found 10/13![American Airlines logo]()
$1,156
This LATAM Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:53 am -
2 stops18h 37m
Sun 12/2011:00 pm -
1 stop13h 20m
Deal found 10/13![LATAM Airlines logo]()
$1,206
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/245:05 pm -
2 stops19h 55m
Sun 3/711:10 pm -
1 stop18h 59m
Deal found 10/13![Delta logo]()
$1,196
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:52 am -
1 stop19h 23m
Sun 12/2011:20 pm -
1 stop21h 12m
Deal found 10/13![American Airlines logo]()
$1,206
This Cheapflightsfares deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:52 am -
1 stop18h 48m
Fri 12/411:10 pm -
1 stop12h 57m
Deal found 10/13![LATAM Airlines logo]()
$1,288
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1611:30 am -
2 stops19h 20m
Fri 3/510:45 pm -
2 stops20h 04m
Deal found 10/11![United Airlines logo]()
$1,467
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:00 am -
1 stop22h 45m
Sun 3/711:45 pm -
1 stop15h 59m
Deal found 10/14![American Airlines logo]()
$1,281
This LATAM Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/296:45 pm -
2 stops19h 20m
Thu 4/17:00 pm -
2 stops23h 55m
Deal found 10/12![LATAM Airlines logo]()
$1,612
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated October 15, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated October 15, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 pm -
1 stop16h 40m
Thu 11/511:10 pm -
1 stop12h 51m
Deal found 10/10![LATAM Airlines logo]()
$1,166
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 pm -
2 stops24h 00m
Tue 11/37:05 pm -
2 stops16h 56m
Deal found 10/10![LATAM Airlines logo]()
$1,196
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 pm -
2 stops24h 00m
Fri 11/67:40 am -
2 stops17h 11m
Deal found 10/10![LATAM Airlines logo]()
$1,226
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:00 pm -
2 stops16h 00m
Thu 11/58:40 am -
2 stops16h 11m
Deal found 10/10![LATAM Airlines logo]()
$1,200
This BusinessClass deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:08 pm -
1 stop15h 27m
Thu 11/510:30 pm -
1 stop23h 12m
Deal found 10/10![GOL logo]()
$1,218
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:00 pm -
2 stops16h 00m
Sat 11/77:40 am -
2 stops17h 11m
Deal found 10/10![LATAM Airlines logo]()
$1,230
This BusinessClass deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:49 am -
1 stop24h 01m
Wed 11/410:45 pm -
1 stop19h 25m
Deal found 10/10![Multiple Airlines logo]()
$1,234
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:00 pm -
1 stop12h 40m
Sat 11/712:15 pm -
2 stops23h 17m
Deal found 10/10![Multiple Airlines logo]()
$1,210
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:00 pm -
1 stop12h 40m
Fri 11/65:07 am -
2 stops17h 05m
Deal found 10/10![Multiple Airlines logo]()
$1,221
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:49 am -
1 stop24h 01m
Thu 12/310:45 pm -
1 stop18h 32m
Deal found 10/12![United Airlines logo]()
$1,156
This LATAM Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:00 am -
3 stops25h 20m
Thu 12/311:10 pm -
2 stops21h 10m
Deal found 10/12![LATAM Airlines logo]()
$1,170
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:01 am -
2 stops20h 24m
Fri 12/410:30 pm -
2 stops20h 08m
Deal found 10/13![American Airlines logo]()
$1,156
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 15, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated October 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:08 pm -
3 stops35h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:58 pm -
3 stops45h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![Multiple Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:41 am -
1 stop19h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![American Airlines logo]()
$729
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:30 am -
2 stops22h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![United Airlines logo]()
$759
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:30 am -
2 stops19h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![United Airlines logo]()
$772
This Cheapflightsfares deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![LATAM Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:52 am -
1 stop18h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Delta logo]()
$786
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:00 am -
3 stops39h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$2,497
This Cheapflightsfares deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:29 pm -
2 stops21h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![LATAM Airlines logo]()
$3,194
This BusinessClass deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:05 am -
2 stops21h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![LATAM Airlines logo]()
$3,220
This BusinessClass deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:00 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![Copa Airlines logo]()
$3,294
This BusinessClass deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/254:29 pm -
2 stops30h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Copa Airlines logo]()
$3,428
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated October 15, 2026.
Round-trip from | $1,086 (LATAM Airlines) |
|---|---|
One-way from | $377 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 15, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 11/3
4:08 pm-5:35 am
3 stops35h 27m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$377
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 11/6
11:41 am-8:45 am
1 stop19h 04m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$729
CharlestonSantiago
CHS Charleston - SCL Santiago Arturo Merino Benitez
CHSSCL
Charleston
Fri 11/6
8:30 am-8:50 am
2 stops22h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$759
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
11:30 am-8:50 am
2 stops19h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$772
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$775
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 11/3
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$786
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 12/8
10:52 am-7:40 am
1 stop18h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$786
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Tue 2/16
10:55 am-7:40 am
1 stop18h 45m
Santiago Arturo Merino Benitez
Mon 3/1
9:50 pm-10:08 am
1 stop14h 18m
$1,086
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Mon 2/15
6:45 pm-2:55 pm
2 stops18h 10m
Santiago Arturo Merino Benitez
Wed 3/3
8:25 pm-10:08 am
2 stops15h 43m
$1,086
Myrtle BeachSantiago
MYR Myrtle Beach Intl - SCL Santiago Arturo Merino Benitez
MYRSCL
Myrtle Beach Intl
Mon 2/15
10:55 am-7:30 am
2 stops18h 35m
Santiago Arturo Merino Benitez
Tue 3/2
8:40 am-11:35 pm
2 stops16h 55m
$1,086
Showing 1-10 of 34 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
MYR-SCL
CHS-SCL
GSP-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
MYR-SCL
CHS-SCL
GSP-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on October 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 15, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$1,134 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$704 | Average$914 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$763 | Average$974 | FlexibilityNo cancel fee | On-timeN/A |