$300+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Aug 12 — Aug 191
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$701
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$714
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:02 pm
CLT
- SCL
2 stops27h 44m
Multiple Airlines
Sun 9/2010:30 am
SCL
- CLT
1 stop30h 35m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$724
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops20h 18m
Multiple Airlines
Sat 8/2911:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$794
This FlightHub deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:15 pm
CLT
- SCL
1 stop15h 35m
LATAM Airlines
Mon 12/711:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 7/13![LATAM Airlines logo]()
$821
This eDestinos deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:53 pm
CHS
- SCL
2 stops36h 07m
Multiple Airlines
Sat 8/1512:43 am
SCL
- CHS
2 stops38h 01m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$821
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:25 am
CHS
- SCL
2 stops19h 30m
LATAM Airlines
Mon 8/318:30 am
SCL
- CHS
3 stops25h 38m
LATAM Airlines
Deal found 7/9![LATAM Airlines logo]()
$845
This Copa Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/131:22 am
SCL
- CLT
2 stops34h 42m
Copa Airlines
Deal found 7/8![Copa Airlines logo]()
$852
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:55 am
CLT
- SCL
1 stop22h 05m
American Airlines
Fri 12/1111:45 pm
SCL
- CLT
1 stop22h 42m
American Airlines
Deal found 7/10![American Airlines logo]()
$854
This LATAM Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:25 am
CHS
- SCL
1 stop19h 50m
LATAM Airlines
Mon 8/248:40 pm
SCL
- CHS
1 stop15h 14m
LATAM Airlines
Deal found 7/9![LATAM Airlines logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/133:48 am
SCL
- CLT
2 stops32h 16m
Copa Airlines
Deal found 7/8![Copa Airlines logo]()
$858
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/8![American Airlines logo]()
$885
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 13, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 13, 2026.
This eDestinos deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:53 pm
CHS
- SCL
2 stops38h 21m
Multiple Airlines
Sun 8/164:14 am
SCL
- CHS
2 stops53h 23m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$839
This Copa Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Sat 11/141:02 am
SCL
- CLT
2 stops35h 02m
Copa Airlines
Deal found 7/11![Copa Airlines logo]()
$852
This LATAM Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:45 pm
CHS
- SCL
1 stop12h 30m
LATAM Airlines
Mon 8/248:40 pm
SCL
- CHS
1 stop22h 11m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$855
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:25 am
CHS
- SCL
1 stop19h 50m
Delta
Mon 8/318:40 pm
SCL
- CHS
1 stop15h 14m
Delta
Deal found 7/9![Delta logo]()
$855
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/8![American Airlines logo]()
$885
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/43:28 pm
SAV
- SCL
1 stop15h 22m
United Airlines
Fri 1/1510:45 pm
SCL
- SAV
2 stops26h 40m
United Airlines
Deal found 7/13![United Airlines logo]()
$1,082
This Copa Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Sat 11/143:19 am
SCL
- CLT
2 stops32h 45m
Copa Airlines
Deal found 7/9![Copa Airlines logo]()
$858
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Mon 11/2311:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 7/9![LATAM Airlines logo]()
$868
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 pm
CLT
- SCL
1 stop12h 30m
American Airlines
Sun 11/1510:15 pm
SCL
- CLT
2 stops16h 08m
American Airlines
Deal found 7/11![American Airlines logo]()
$904
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:48 am
CHS
- SCL
2 stops20h 07m
Delta
Sun 8/1610:55 pm
SCL
- CHS
1 stop17h 32m
Delta
Deal found 7/12![Delta logo]()
$915
This Copa Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/133:48 am
SCL
- CLT
2 stops32h 16m
Copa Airlines
Deal found 7/8![Copa Airlines logo]()
$858
This oojo deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:45 pm
CHS
- SCL
3 stops26h 30m
LATAM Airlines
Fri 8/218:40 am
SCL
- CHS
3 stops27h 14m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$887
This Kiwi.com deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:19 pm
CLT
- SCL
1 stop15h 36m
Multiple Airlines
Fri 9/183:14 am
SCL
- CLT
2 stops35h 37m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$991
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:51 pm
CHS
- SCL
1 stop12h 24m
Delta
Fri 10/167:45 am
SCL
- CHS
2 stops17h 14m
Delta
Deal found 7/10![Delta logo]()
$915
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2311:03 am
SAV
- SCL
2 stops20h 02m
American Airlines
Sun 8/308:50 pm
SCL
- SAV
2 stops15h 16m
American Airlines
Deal found 7/9![American Airlines logo]()
$952
This oojo deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1412:00 pm
GSP
- SCL
2 stops15h 35m
LATAM Airlines
Tue 1/1210:20 am
SCL
- GSP
2 stops15h 17m
LATAM Airlines
Deal found 7/11![LATAM Airlines logo]()
$902
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:01 pm
CHS
- SCL
2 stops16h 54m
Delta
Fri 8/2110:55 pm
SCL
- CHS
1 stop22h 25m
Delta
Deal found 7/12![Delta logo]()
$915
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:56 pm
MYR
- SCL
2 stops16h 29m
American Airlines
Wed 10/79:30 pm
SCL
- MYR
2 stops22h 21m
American Airlines
Deal found 7/13![American Airlines logo]()
$952
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:20 pm
GSP
- SCL
3 stops27h 55m
LATAM Airlines
Tue 8/188:30 am
SCL
- GSP
3 stops26h 37m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$931
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:05 pm
CLT
- SCL
2 stops17h 00m
Delta
Fri 12/117:25 pm
SCL
- CLT
2 stops20h 06m
Delta
Deal found 7/10![Delta logo]()
$944
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
SAV
- SCL
1 stop24h 25m
American Airlines
Tue 8/188:50 pm
SCL
- SAV
2 stops22h 20m
American Airlines
Deal found 7/12![American Airlines logo]()
$960
This Travelocity deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:17 pm
CLT
- SCL
2 stops14h 38m
LATAM Airlines
Sat 11/1412:10 am
SCL
- CLT
1 stop12h 54m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$975
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/155:40 am
GSP
- SCL
2 stops21h 50m
Delta
Tue 12/2911:48 pm
SCL
- GSP
2 stops25h 49m
Delta
Deal found 7/12![Delta logo]()
$1,020
This LATAM Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:18 pm
MYR
- SCL
1 stop16h 57m
LATAM Airlines
Tue 10/612:05 am
SCL
- MYR
2 stops18h 58m
LATAM Airlines
Deal found 7/13![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:00 pm
CLT
- SCL
1 stop19h 15m
Delta
Mon 9/218:40 pm
SCL
- CLT
1 stop15h 31m
Delta
Deal found 7/9![Delta logo]()
$1,034
This oojo deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:06 am
SAV
- SCL
2 stops22h 49m
LATAM Airlines
Tue 8/188:30 am
SCL
- SAV
3 stops27h 10m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$1,028
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:00 am
CLT
- SCL
2 stops18h 40m
Delta
Mon 9/217:55 pm
SCL
- CLT
2 stops16h 16m
Delta
Deal found 7/9![Delta logo]()
$1,034
This LATAM Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:39 pm
SAV
- SCL
2 stops16h 21m
LATAM Airlines
Mon 9/218:40 pm
SCL
- SAV
1 stop15h 54m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$1,047
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/55:35 pm
SAV
- SCL
1 stop12h 05m
Delta
Sun 1/1711:48 pm
SCL
- SAV
2 stops19h 55m
Delta
Deal found 7/13![Delta logo]()
$1,047
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:47 pm
SAV
- SCL
1 stop18h 28m
Delta
Tue 8/1810:55 pm
SCL
- SAV
1 stop18h 16m
Delta
Deal found 7/12![Delta logo]()
$1,047
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated July 13, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated July 13, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2512:59 pm
CHS
- SCL
2 stops32h 56m
LATAM Airlines
Sun 8/211:05 pm
SCL
- CHS
2 stops24h 54m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$888
This eDestinos deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:53 pm
CHS
- SCL
2 stops36h 07m
Multiple Airlines
Sat 8/1512:43 am
SCL
- CHS
2 stops38h 01m
Multiple Airlines
Deal found 7/10![Multiple Airlines logo]()
$821
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:43 pm
CLT
- SCL
2 stops28h 07m
Multiple Airlines
Sun 8/1610:25 am
SCL
- CLT
1 stop30h 47m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$865
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:48 am
CHS
- SCL
2 stops20h 07m
Delta
Sun 8/1610:55 pm
SCL
- CHS
1 stop17h 32m
Delta
Deal found 7/12![Delta logo]()
$915
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Tue 8/188:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/8![American Airlines logo]()
$885
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:28 pm
GSP
- SCL
2 stops17h 27m
LATAM Airlines
Tue 8/188:30 am
SCL
- GSP
3 stops26h 37m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$902
This oojo deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:45 pm
CHS
- SCL
3 stops26h 30m
LATAM Airlines
Fri 8/218:40 am
SCL
- CHS
3 stops27h 14m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$887
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$714
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops20h 18m
Multiple Airlines
Sat 8/2911:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$794
This LATAM Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:45 pm
CHS
- SCL
1 stop12h 30m
LATAM Airlines
Mon 8/248:40 pm
SCL
- CHS
1 stop22h 11m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$855
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$701
This oojo deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:25 am
CHS
- SCL
2 stops19h 30m
LATAM Airlines
Mon 8/318:30 am
SCL
- CHS
3 stops25h 38m
LATAM Airlines
Deal found 7/9![LATAM Airlines logo]()
$845
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 13, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:33 pm
CLT
- SCL
2 stops15h 37m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:43 pm
CLT
- SCL
2 stops29h 17m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:24 pm
CLT
- SCL
2 stops38h 36m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/48:02 pm
CLT
- SCL
2 stops54h 58m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:33 pm
CLT
- SCL
2 stops36h 05m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:02 pm
CLT
- SCL
2 stops24h 17m
Multiple Airlines
Deal found 7/11![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/158:11 pm
CLT
- SCL
2 stops31h 35m
Multiple Airlines
Deal found 7/9![Multiple Airlines logo]()
$342
This eDestinos deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:02 pm
CLT
- SCL
2 stops41h 18m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:45 pm
GSP
- SCL
2 stops33h 15m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:13 pm
GSP
- SCL
2 stops26h 30m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:40 pm
GSP
- SCL
2 stops35h 20m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:45 pm
GSP
- SCL
2 stops40h 50m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$494
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 13, 2026.
Round-trip from | $701 (Kiwi.com) |
|---|---|
One-way from | $300 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Sun 8/9
2:53 pm-5:14 am
2 stops38h 21m
Santiago Arturo Merino Benitez
Sun 8/16
4:14 am-9:37 am
2 stops53h 23m
$839
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 11/6
6:00 am-5:46 am
2 stops21h 46m
Santiago Arturo Merino Benitez
Sat 11/14
1:02 am-10:04 am
2 stops35h 02m
$852
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/20
6:45 pm-7:15 am
1 stop12h 30m
Santiago Arturo Merino Benitez
Mon 8/24
8:40 pm-6:51 pm
1 stop22h 11m
$855
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 8/24
11:25 am-7:15 am
1 stop19h 50m
Santiago Arturo Merino Benitez
Mon 8/31
8:40 pm-11:54 am
1 stop15h 14m
$855
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 11/7
6:00 am-5:46 am
2 stops21h 46m
Santiago Arturo Merino Benitez
Sat 11/14
3:19 am-10:04 am
2 stops32h 45m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 11/5
6:00 am-11:36 pm
2 stops15h 36m
Santiago Arturo Merino Benitez
Fri 11/13
3:48 am-10:04 am
2 stops32h 16m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 11/6
1:15 pm-7:50 am
1 stop16h 35m
Santiago Arturo Merino Benitez
Mon 11/23
11:55 pm-1:54 pm
1 stop15h 59m
$868
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 8/13
6:40 pm-7:05 am
1 stop12h 25m
Santiago Arturo Merino Benitez
Tue 8/18
8:50 pm-6:10 pm
1 stop21h 20m
$885
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Fri 8/14
6:45 pm-9:15 pm
3 stops26h 30m
Santiago Arturo Merino Benitez
Fri 8/21
8:40 am-11:54 am
3 stops27h 14m
$887
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Mon 12/14
12:00 pm-5:35 am
2 stops15h 35m
Santiago Arturo Merino Benitez
Tue 1/12
10:20 am-11:37 pm
2 stops15h 17m
$902
Showing 1-10 of 50 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
MYR-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
SAV-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on July 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 13, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$743 | Average$954 | FlexibilityNo cancel fee | On-timeN/A |