$315+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Santiago with Cheapflights
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:48 pm
CLT
- SCL
2 stops24h 42m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$796
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Fri 6/125:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$805
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Thu 10/1510:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$810
This LATAM Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm
CHS
- SCL
2 stops16h 06m
LATAM Airlines
Mon 11/234:50 pm
SCL
- CHS
2 stops18h 52m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$825
This FlightHub deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:20 pm
CLT
- SCL
2 stops13h 15m
LATAM Airlines
Mon 11/3011:05 pm
SCL
- CLT
2 stops21h 07m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$842
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:45 am
CLT
- SCL
1 stop25h 10m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$844
This FlightHub deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Fri 11/2011:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$845
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:34 pm
CLT
- SCL
2 stops18h 51m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops35h 11m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$846
This Orbitz deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:55 pm
CHS
- SCL
1 stop11h 45m
LATAM Airlines
Mon 11/2312:10 am
SCL
- CHS
1 stop11h 32m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$846
This eDestinos deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- SCL
2 stops27h 28m
Multiple Airlines
Thu 5/285:00 am
SCL
- CLT
2 stops36h 13m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$857
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:12 am
MYR
- SCL
2 stops18h 33m
American Airlines
Wed 12/910:15 pm
SCL
- MYR
2 stops17h 44m
American Airlines
Deal found 5/5![American Airlines logo]()
$880
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:20 pm
MYR
- SCL
2 stops39h 30m
United Airlines
Thu 12/1010:45 pm
SCL
- MYR
2 stops17h 48m
United Airlines
Deal found 5/5![United Airlines logo]()
$898
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:45 am
CLT
- SCL
1 stop25h 10m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$844
This Copa Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:44 pm
CLT
- SCL
2 stops33h 19m
Copa Airlines
Mon 11/303:50 am
SCL
- CLT
2 stops31h 54m
Copa Airlines
Deal found 5/1![Copa Airlines logo]()
$978
This KAYAK deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/212:19 pm
CLT
- SCL
2 stops17h 41m
LATAM Airlines
Mon 8/3111:05 pm
SCL
- CLT
2 stops19h 12m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$1,017
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/309:43 am
CLT
- SCL
2 stops20h 17m
Delta
Sat 8/810:55 pm
SCL
- CLT
1 stop24h 12m
Delta
Deal found 5/1![Delta logo]()
$1,025
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:15 am
GSP
- SCL
2 stops19h 35m
American Airlines
Fri 8/288:30 pm
SCL
- GSP
2 stops17h 39m
American Airlines
Deal found 5/1![American Airlines logo]()
$1,030
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:55 am
CHS
- SCL
2 stops18h 55m
United Airlines
Mon 11/210:45 pm
SCL
- CHS
2 stops21h 00m
United Airlines
Deal found 4/30![United Airlines logo]()
$1,150
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:45 am
CLT
- SCL
1 stop23h 50m
Multiple Airlines
Thu 8/278:20 pm
SCL
- CLT
2 stops43h 51m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$888
This KAYAK deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/131:05 pm
CHS
- SCL
2 stops17h 50m
LATAM Airlines
Thu 7/2311:00 pm
SCL
- CHS
2 stops19h 54m
LATAM Airlines
Deal found 5/5![LATAM Airlines logo]()
$1,022
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:18 pm
MYR
- SCL
1 stop16h 57m
Delta
Sun 8/238:40 pm
SCL
- MYR
1 stop14h 07m
Delta
Deal found 5/4![Delta logo]()
$1,095
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Sun 6/213:20 pm
SCL
- CLT
2 stops32h 23m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,007
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:54 pm
SAV
- SCL
2 stops16h 11m
American Airlines
Tue 6/239:00 pm
SCL
- SAV
2 stops23h 42m
American Airlines
Deal found 5/1![American Airlines logo]()
$1,127
This KAYAK deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:19 pm
CLT
- SCL
3 stops25h 06m
LATAM Airlines
Thu 7/167:25 am
SCL
- CLT
2 stops16h 33m
LATAM Airlines
Deal found 5/5![LATAM Airlines logo]()
$1,052
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:35 pm
SAV
- SCL
1 stop15h 15m
United Airlines
Mon 11/210:45 pm
SCL
- SAV
1 stop16h 15m
United Airlines
Deal found 5/4![United Airlines logo]()
$1,195
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:18 pm
MYR
- SCL
1 stop16h 57m
Delta
Sun 8/238:40 pm
SCL
- MYR
1 stop14h 07m
Delta
Deal found 5/4![Delta logo]()
$1,095
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:56 am
SAV
- SCL
2 stops20h 09m
American Airlines
Wed 6/249:00 pm
SCL
- SAV
2 stops17h 23m
American Airlines
Deal found 5/2![American Airlines logo]()
$1,130
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:29 pm
CLT
- SCL
2 stops17h 01m
Multiple Airlines
Tue 5/263:20 pm
SCL
- CLT
3 stops26h 24m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,029
This LATAM Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/110:03 am
GSP
- SCL
2 stops19h 57m
LATAM Airlines
Tue 12/111:10 pm
SCL
- GSP
1 stop13h 48m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$1,065
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:15 pm
GSP
- SCL
1 stop13h 35m
United Airlines
Mon 11/210:45 pm
SCL
- GSP
1 stop18h 33m
United Airlines
Deal found 4/30![United Airlines logo]()
$1,195
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:37 pm
GSP
- SCL
2 stops18h 28m
American Airlines
Tue 6/239:00 pm
SCL
- GSP
2 stops22h 02m
American Airlines
Deal found 5/2![American Airlines logo]()
$1,130
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 am
MYR
- SCL
2 stops24h 00m
Delta
Sat 8/2211:00 pm
SCL
- MYR
2 stops24h 30m
Delta
Deal found 5/4![Delta logo]()
$1,150
This Trip.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
CLT
- SCL
3 stops44h 35m
Multiple Airlines
Mon 6/295:00 am
SCL
- CLT
3 stops40h 35m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$1,052
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:00 pm
MYR
- SCL
2 stops17h 50m
United Airlines
Mon 11/210:45 pm
SCL
- MYR
2 stops17h 48m
United Airlines
Deal found 4/30![United Airlines logo]()
$1,200
This LATAM Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:15 pm
MYR
- SCL
2 stops15h 35m
LATAM Airlines
Mon 11/25:00 am
SCL
- MYR
2 stops38h 55m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$1,110
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
SAV
- SCL
1 stop25h 05m
American Airlines
Wed 6/249:00 pm
SCL
- SAV
1 stop20h 52m
American Airlines
Deal found 5/3![American Airlines logo]()
$1,134
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
- SCL
2 stops31h 02m
Multiple Airlines
Fri 6/1210:30 am
SCL
- CLT
1 stop30h 44m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$1,058
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/152:10 pm
MYR
- SCL
1 stop16h 15m
Delta
Mon 8/2410:55 pm
SCL
- MYR
1 stop35h 06m
Delta
Deal found 5/4![Delta logo]()
$1,204
This LATAM Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:25 pm
GSP
- SCL
2 stops15h 25m
LATAM Airlines
Mon 11/28:15 am
SCL
- GSP
2 stops28h 43m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$1,136
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:45 pm
CLT
- SCL
1 stop14h 10m
Multiple Airlines
Sun 5/2412:30 am
SCL
- CLT
2 stops37h 41m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,071
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:00 am
MYR
- SCL
1 stop19h 25m
Delta
Fri 8/2110:55 pm
SCL
- MYR
1 stop35h 06m
Delta
Deal found 5/4![Delta logo]()
$1,205
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:59 pm
CHS
- SCL
2 stops17h 06m
LATAM Airlines
Mon 11/211:10 pm
SCL
- CHS
1 stop19h 41m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$1,145
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated May 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:58 pm
CLT
- SCL
2 stops50h 45m
Multiple Airlines
Sat 6/66:00 pm
SCL
- CLT
2 stops23h 13m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$971
This eDestinos deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- SCL
2 stops27h 28m
Multiple Airlines
Thu 5/285:00 am
SCL
- CLT
2 stops36h 13m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$857
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:48 pm
CLT
- SCL
2 stops24h 42m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$796
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:29 pm
CLT
- SCL
2 stops17h 01m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$933
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Fri 6/125:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$805
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:03 pm
CLT
- SCL
2 stops31h 32m
Multiple Airlines
Mon 6/298:30 am
SCL
- CLT
2 stops24h 46m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$996
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Sun 6/213:20 pm
SCL
- CLT
2 stops32h 23m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,007
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:05 pm
SAV
- SCL
1 stop12h 10m
Multiple Airlines
Tue 6/233:20 pm
SCL
- SAV
2 stops43h 05m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,121
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:54 pm
SAV
- SCL
2 stops16h 11m
American Airlines
Tue 6/239:00 pm
SCL
- SAV
2 stops23h 42m
American Airlines
Deal found 5/1![American Airlines logo]()
$1,127
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:56 am
SAV
- SCL
2 stops20h 09m
American Airlines
Wed 6/249:00 pm
SCL
- SAV
2 stops17h 23m
American Airlines
Deal found 5/1![American Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:37 pm
GSP
- SCL
2 stops18h 28m
American Airlines
Tue 6/239:00 pm
SCL
- GSP
2 stops22h 02m
American Airlines
Deal found 5/2![American Airlines logo]()
$1,130
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:53 pm
MYR
- SCL
2 stops18h 12m
American Airlines
Thu 6/259:00 pm
SCL
- MYR
2 stops23h 01m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,130
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:58 pm
CLT
- SCL
2 stops50h 45m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:45 pm
CLT
- SCL
3 stops42h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:00 pm
CLT
- SCL
3 stops37h 35m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- SCL
2 stops26h 45m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:29 pm
CLT
- SCL
2 stops25h 06m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/101:12 pm
CLT
- SCL
2 stops37h 08m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$457
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:58 pm
CLT
- SCL
3 stops32h 47m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$459
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated May 5, 2026.
Round-trip from | $796 (Mytrip) |
|---|---|
One-way from | $315 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 8/6
5:45 am-6:55 am
1 stop25h 10m
Santiago Arturo Merino Benitez
Mon 8/31
5:00 am-5:14 pm
2 stops36h 14m
$844
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 8/11
5:45 am-5:35 am
1 stop23h 50m
Santiago Arturo Merino Benitez
Thu 8/27
8:20 pm-4:11 pm
2 stops43h 51m
$888
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sat 8/1
7:44 pm-5:03 am
2 stops33h 19m
Santiago Arturo Merino Benitez
Mon 11/30
3:50 am-9:44 am
2 stops31h 54m
$978
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 6/16
7:12 am-5:30 am
3 stops22h 18m
Santiago Arturo Merino Benitez
Sun 6/21
3:20 pm-11:43 pm
2 stops32h 23m
$1,007
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 8/2
12:19 pm-6:00 am
2 stops17h 41m
Santiago Arturo Merino Benitez
Mon 8/31
11:05 pm-6:17 pm
2 stops19h 12m
$1,017
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Mon 7/13
1:05 pm-6:55 am
2 stops17h 50m
Santiago Arturo Merino Benitez
Thu 7/23
11:00 pm-6:54 pm
2 stops19h 54m
$1,022
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 7/30
9:43 am-6:00 am
2 stops20h 17m
Santiago Arturo Merino Benitez
Sat 8/8
10:55 pm-11:07 pm
1 stop24h 12m
$1,025
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 5/22
12:29 pm-5:30 am
2 stops17h 01m
Santiago Arturo Merino Benitez
Tue 5/26
3:20 pm-5:44 pm
3 stops26h 24m
$1,029
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Thu 8/20
11:15 am-6:50 am
2 stops19h 35m
Santiago Arturo Merino Benitez
Fri 8/28
8:30 pm-2:09 pm
2 stops17h 39m
$1,030
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Tue 7/7
12:19 pm-1:25 pm
3 stops25h 06m
Santiago Arturo Merino Benitez
Thu 7/16
7:25 am-11:58 pm
2 stops16h 33m
$1,052
Showing 1-10 of 39 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
SAV-SCL
MYR-SCL
GSP-SCL
CHS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
SAV-SCL
MYR-SCL
GSP-SCL
How much does it cost to fly round-trip from South Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 3 airlines flying from South Carolina to Santiago
Discover the top 3 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$562 | Average$1,022 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$753 | Average$948 | FlexibilityNo cancel fee | On-timeN/A |