$269+ Cheap flights from South Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Aug 7 — Aug 141
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to SantiagoExplore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
This oojo deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:30 pm
CLT
- SCL
3 stops19h 00m
LATAM Airlines
Thu 12/311:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$824
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$835
This oojo deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:55 am
CLT
- SCL
2 stops20h 35m
LATAM Airlines
Thu 11/1211:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 7/3![LATAM Airlines logo]()
$840
This oojo deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:40 am
CHS
- SCL
2 stops20h 50m
LATAM Airlines
Thu 11/1211:05 pm
SCL
- CHS
2 stops19h 46m
LATAM Airlines
Deal found 7/4![LATAM Airlines logo]()
$845
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:02 pm
CLT
- SCL
2 stops30h 58m
Multiple Airlines
Tue 7/2110:25 am
SCL
- CLT
1 stop30h 47m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$846
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$850
This Copa Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Fri 11/133:19 am
SCL
- CLT
2 stops32h 45m
Copa Airlines
Deal found 7/7![Copa Airlines logo]()
$852
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:16 pm
CLT
- SCL
1 stop17h 44m
American Airlines
Thu 11/1210:15 pm
SCL
- CLT
1 stop12h 56m
American Airlines
Deal found 7/3![American Airlines logo]()
$854
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
1 stop12h 47m
Delta
Thu 7/2310:55 pm
SCL
- CHS
1 stop22h 35m
Delta
Deal found 7/3![Delta logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/133:48 am
SCL
- CLT
2 stops32h 16m
Copa Airlines
Deal found 7/7![Copa Airlines logo]()
$858
This oojo deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Sun 11/1512:40 pm
SCL
- CLT
2 stops37h 13m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$863
This LATAM Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:10 pm
CHS
- SCL
3 stops20h 15m
LATAM Airlines
Tue 9/227:50 am
SCL
- CHS
2 stops17h 07m
LATAM Airlines
Deal found 7/4![LATAM Airlines logo]()
$863
Best flights from South Carolina to SantiagoDiscover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
Discover carefully curated flight deals from South Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
This Copa Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
CLT
- SCL
2 stops21h 46m
Copa Airlines
Fri 11/133:19 am
SCL
- CLT
2 stops32h 45m
Copa Airlines
Deal found 7/7![Copa Airlines logo]()
$852
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:55 pm
CHS
- SCL
1 stop16h 30m
Delta
Tue 9/228:40 pm
SCL
- CHS
1 stop14h 26m
Delta
Deal found 7/4![Delta logo]()
$855
This LATAM Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:35 pm
CHS
- SCL
1 stop12h 05m
LATAM Airlines
Thu 11/1211:10 pm
SCL
- CHS
1 stop12h 32m
LATAM Airlines
Deal found 7/4![LATAM Airlines logo]()
$855
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:59 pm
CLT
- SCL
2 stops50h 51m
Multiple Airlines
Mon 8/1011:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$872
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
GSP
- SCL
1 stop23h 25m
American Airlines
Tue 8/258:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/4![American Airlines logo]()
$881
This Copa Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am
CLT
- SCL
2 stops15h 36m
Copa Airlines
Fri 11/133:48 am
SCL
- CLT
2 stops32h 16m
Copa Airlines
Deal found 7/7![Copa Airlines logo]()
$858
This oojo deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Sat 11/1411:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 7/7![LATAM Airlines logo]()
$868
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:15 am
CHS
- SCL
2 stops16h 45m
Delta
Sat 11/1411:55 pm
SCL
- CHS
1 stop18h 50m
Delta
Deal found 7/3![Delta logo]()
$885
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:37 pm
GSP
- SCL
2 stops17h 28m
American Airlines
Mon 8/178:50 pm
SCL
- GSP
2 stops17h 57m
American Airlines
Deal found 7/6![American Airlines logo]()
$920
This oojo deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:00 pm
CHS
- SCL
2 stops14h 55m
LATAM Airlines
Sat 11/148:30 am
SCL
- CHS
3 stops34h 21m
LATAM Airlines
Deal found 7/3![LATAM Airlines logo]()
$874
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:41 pm
CHS
- SCL
1 stop12h 34m
Delta
Sat 8/2912:20 pm
SCL
- CHS
2 stops20h 38m
Delta
Deal found 7/7![Delta logo]()
$915
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:00 am
CHS
- SCL
1 stop25h 05m
American Airlines
Sat 8/298:50 pm
SCL
- CHS
1 stop27h 09m
American Airlines
Deal found 7/7![American Airlines logo]()
$932
This LATAM Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:10 am
CHS
- SCL
3 stops26h 39m
LATAM Airlines
Sat 9/126:45 pm
SCL
- CHS
2 stops17h 53m
LATAM Airlines
Deal found 7/7![LATAM Airlines logo]()
$885
This Mytrip deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:55 am
CLT
- SCL
3 stops25h 45m
Multiple Airlines
Sat 11/1412:07 pm
SCL
- CLT
3 stops34h 59m
Multiple Airlines
Deal found 7/7![Multiple Airlines logo]()
$1,073
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:31 pm
SAV
- SCL
2 stops16h 34m
American Airlines
Fri 8/288:50 pm
SCL
- SAV
1 stop20h 36m
American Airlines
Deal found 7/7![American Airlines logo]()
$952
This Travelocity deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:15 pm
CLT
- SCL
1 stop16h 35m
LATAM Airlines
Sat 11/1412:55 am
SCL
- CLT
1 stop14h 59m
LATAM Airlines
Deal found 7/7![LATAM Airlines logo]()
$920
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:43 am
MYR
- SCL
1 stop19h 32m
Delta
Thu 8/278:40 pm
SCL
- MYR
1 stop21h 27m
Delta
Deal found 7/6![Delta logo]()
$1,027
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:28 pm
SAV
- SCL
1 stop10h 37m
American Airlines
Thu 8/278:50 pm
SCL
- SAV
2 stops15h 16m
American Airlines
Deal found 7/6![American Airlines logo]()
$952
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:33 am
CLT
- SCL
1 stop21h 42m
Delta
Wed 9/28:40 pm
SCL
- CLT
1 stop13h 31m
Delta
Deal found 7/4![Delta logo]()
$1,034
This LATAM Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:20 pm
GSP
- SCL
2 stops24h 05m
LATAM Airlines
Tue 8/188:40 pm
SCL
- GSP
1 stop14h 27m
LATAM Airlines
Deal found 7/4![LATAM Airlines logo]()
$945
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Sat 8/158:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/6![American Airlines logo]()
$1,004
This oojo deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/95:20 pm
GSP
- SCL
2 stops26h 25m
LATAM Airlines
Sun 8/168:30 am
SCL
- GSP
3 stops26h 10m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$946
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:17 pm
CHS
- SCL
1 stop16h 58m
Delta
Sat 9/1210:55 pm
SCL
- CHS
1 stop17h 48m
Delta
Deal found 7/4![Delta logo]()
$1,071
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/510:44 am
MYR
- SCL
2 stops20h 21m
American Airlines
Sat 9/199:30 pm
SCL
- MYR
2 stops19h 02m
American Airlines
Deal found 7/4![American Airlines logo]()
$1,012
This oojo deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:28 am
GSP
- SCL
2 stops22h 27m
LATAM Airlines
Sat 8/158:30 am
SCL
- GSP
3 stops26h 05m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$1,004
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:45 pm
CLT
- SCL
1 stop11h 20m
American Airlines
Fri 8/288:50 pm
SCL
- CLT
2 stops16h 38m
American Airlines
Deal found 7/7![American Airlines logo]()
$1,084
This LATAM Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:18 pm
MYR
- SCL
1 stop16h 57m
LATAM Airlines
Thu 8/274:15 am
SCL
- MYR
2 stops19h 15m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:52 am
GSP
- SCL
2 stops19h 48m
Delta
Mon 11/3011:48 pm
SCL
- GSP
2 stops21h 01m
Delta
Deal found 7/6![Delta logo]()
$1,338
This oojo deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:06 am
SAV
- SCL
2 stops22h 49m
LATAM Airlines
Thu 8/278:30 am
SCL
- SAV
3 stops27h 10m
LATAM Airlines
Deal found 7/6![LATAM Airlines logo]()
$1,028
This LATAM Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:00 am
SAV
- SCL
2 stops21h 00m
LATAM Airlines
Mon 9/215:40 am
SCL
- SAV
2 stops19h 15m
LATAM Airlines
Deal found 7/2![LATAM Airlines logo]()
$1,047
Last-minute flights from South Carolina to SantiagoDiscover last-minute flight deals from South Carolina to Santiago. Data last updated July 8, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Santiago. Data last updated July 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:02 pm
CLT
- SCL
2 stops30h 58m
Multiple Airlines
Tue 7/2110:25 am
SCL
- CLT
1 stop30h 47m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$846
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:28 pm
CHS
- SCL
1 stop12h 47m
Delta
Thu 7/2310:55 pm
SCL
- CHS
1 stop22h 35m
Delta
Deal found 7/3![Delta logo]()
$855
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:59 pm
CLT
- SCL
2 stops50h 51m
Multiple Airlines
Mon 8/1011:00 pm
SCL
- CLT
1 stop18h 12m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$872
This Expedia deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:25 am
CHS
- SCL
2 stops25h 55m
LATAM Airlines
Sat 8/811:05 pm
SCL
- CHS
2 stops35h 15m
LATAM Airlines
Deal found 7/7![LATAM Airlines logo]()
$886
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Sun 8/168:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/6![American Airlines logo]()
$915
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:40 pm
GSP
- SCL
1 stop12h 25m
American Airlines
Sun 8/168:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/6![American Airlines logo]()
$885
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
GSP
- SCL
1 stop23h 25m
American Airlines
Tue 8/258:50 pm
SCL
- GSP
1 stop21h 20m
American Airlines
Deal found 7/4![American Airlines logo]()
$881
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$850
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:56 am
CLT
- SCL
2 stops20h 18m
Multiple Airlines
Sat 8/2911:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$882
This LATAM Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:10 am
CHS
- SCL
3 stops26h 39m
LATAM Airlines
Sat 9/126:45 pm
SCL
- CHS
2 stops17h 53m
LATAM Airlines
Deal found 7/7![LATAM Airlines logo]()
$885
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:56 am
CLT
- SCL
2 stops16h 54m
Multiple Airlines
Sun 8/3011:00 pm
SCL
- CLT
1 stop17h 46m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$835
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:41 pm
CHS
- SCL
1 stop12h 34m
Delta
Sat 8/2912:20 pm
SCL
- CHS
2 stops20h 38m
Delta
Deal found 7/7![Delta logo]()
$915
One-way flights from South Carolina to SantiagoSearch for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
Search for one-way flight options from South Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:32 pm
GSP
- SCL
2 stops30h 24m
Multiple Airlines
Deal found 7/3![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:13 pm
CHS
- SCL
2 stops38h 57m
Multiple Airlines
Deal found 7/8![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:41 pm
MYR
- SCL
2 stops38h 29m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:23 pm
CHS
- SCL
2 stops15h 52m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$511
This oojo deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:00 am
CLT
- SCL
1 stop19h 50m
LATAM Airlines
Deal found 7/4![LATAM Airlines logo]()
$568
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:53 pm
CHS
- SCL
2 stops16h 22m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$580
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:52 pm
CHS
- SCL
1 stop16h 33m
LATAM Airlines
Deal found 7/8![LATAM Airlines logo]()
$592
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:25 am
CHS
- SCL
2 stops17h 25m
Delta
Deal found 7/6![Delta logo]()
$594
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:08 pm
GSP
- SCL
1 stop10h 42m
American Airlines
Deal found 7/3![American Airlines logo]()
$610
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:21 pm
CHS
- SCL
1 stop36h 04m
Delta
Deal found 7/6![Delta logo]()
$610
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/83:00 pm
CHS
- SCL
1 stop16h 15m
Delta
Deal found 7/6![Delta logo]()
$624
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:16 pm
CLT
- SCL
1 stop17h 44m
American Airlines
Deal found 7/4![American Airlines logo]()
$647
Find flight deals from South Carolina to Santiago
Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 8, 2026.
Round-trip from | $824 (oojo) |
|---|---|
One-way from | $269 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 11/6
6:00 am-5:46 am
2 stops21h 46m
Santiago Arturo Merino Benitez
Fri 11/13
3:19 am-10:04 am
2 stops32h 45m
$852
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Tue 9/15
12:55 pm-6:25 am
1 stop16h 30m
Santiago Arturo Merino Benitez
Tue 9/22
8:40 pm-10:06 am
1 stop14h 26m
$855
Quickest round-trip
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Tue 11/3
5:35 pm-7:40 am
1 stop12h 05m
Santiago Arturo Merino Benitez
Thu 11/12
11:10 pm-9:42 am
1 stop12h 32m
$855
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 11/5
6:00 am-11:36 pm
2 stops15h 36m
Santiago Arturo Merino Benitez
Fri 11/13
3:48 am-10:04 am
2 stops32h 16m
$858
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 11/5
1:15 pm-7:50 am
1 stop16h 35m
Santiago Arturo Merino Benitez
Sat 11/14
11:55 pm-1:54 pm
1 stop15h 59m
$868
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 8/3
10:59 pm-1:50 am
2 stops50h 51m
Santiago Arturo Merino Benitez
Mon 8/10
11:00 pm-5:12 pm
1 stop18h 12m
$872
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 11/4
2:00 pm-6:55 am
2 stops14h 55m
Santiago Arturo Merino Benitez
Sat 11/14
8:30 am-4:51 pm
3 stops34h 21m
$874
GreenvilleSantiago
GSP - SCL
GSPSCL
Greenville
Tue 8/18
7:00 am-6:25 am
1 stop23h 25m
Santiago Arturo Merino Benitez
Tue 8/25
8:50 pm-6:10 pm
1 stop21h 20m
$881
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Wed 11/4
11:15 am-6:00 am
2 stops16h 45m
Santiago Arturo Merino Benitez
Sat 11/14
11:55 pm-4:45 pm
1 stop18h 50m
$885
CharlestonSantiago
CHS - SCL
CHSSCL
Charleston
Thu 8/20
8:10 am-10:49 am
3 stops26h 39m
Santiago Arturo Merino Benitez
Sat 9/12
6:45 pm-11:38 am
2 stops17h 53m
$885
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
CLT-SCL
CHS-SCL
GSP-SCL
MYR-SCL
SAV-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Santiago
USSC-SCL
CLT-SCL
CHS-SCL
GSP-SCL
MYR-SCL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Santiago by cabin class
Find flights from South Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Santiago flights
Browse other South Carolina and Santiago flight options. Last updated on July 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 8, 2026.
South Carolina to Santiago flights
Consider these flights traveling from South Carolina to Santiago.
Top 2 airlines flying from South Carolina to Santiago
Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$859 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$703 | Average$883 | FlexibilityNo cancel fee | On-time71% |