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$337+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated September 15, 2025.

Round-trip from

$591
(Mytrip)

One-way from

$337
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
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One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:50 pmCLT - SCL
2 stops23h 55mMultiple Airlines
Thu 10/23:30 pmSCL - CLT
3 stops32h 29mMultiple Airlines
Deal found 9/15$591
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:42 pmCLT - SCL
2 stops21h 33mMultiple Airlines
Sun 11/2310:50 amSCL - CLT
1 stop31h 11mMultiple Airlines
Deal found 9/15$637
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - SCL
2 stops21h 33mMultiple Airlines
Sun 11/1611:25 pmSCL - CLT
1 stop24h 32mMultiple Airlines
Deal found 9/15$644
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/41:50 pmCLT - SCL
2 stops31h 25mMultiple Airlines
Wed 10/811:00 amSCL - CLT
1 stop26h 39mMultiple Airlines
Deal found 9/14$645
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2710:11 pmCLT - SCL
2 stops29h 19mMultiple Airlines
Sat 12/610:35 amSCL - CLT
1 stop23h 40mMultiple Airlines
Deal found 9/15$661
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1412:50 pmCHS - SCL
1 stop15h 55mDelta
Mon 10/2010:55 pmSCL - CHS
1 stop19h 56mDelta
Deal found 9/14$664
This LATAM Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:55 pmCHS - SCL
2 stops16h 55mLATAM Airlines
Mon 9/296:35 amSCL - CHS
2 stops18h 13mLATAM Airlines
Deal found 9/13$668
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/11:11 pmCLT - SCL
1 stop17h 34mLATAM Airlines
Tue 10/1410:55 pmSCL - CLT
1 stop15h 28mLATAM Airlines
Deal found 9/15$684
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2710:11 pmCLT - SCL
2 stops29h 19mMultiple Airlines
Sun 12/710:35 amSCL - CLT
1 stop23h 40mMultiple Airlines
Deal found 9/15$687
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:13 pmGSP - SCL
2 stops19h 12mLATAM Airlines
Tue 10/1410:55 pmSCL - GSP
2 stops21h 01mLATAM Airlines
Deal found 9/14$703
This LATAM Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1212:54 pmCHS - SCL
1 stop17h 06mLATAM Airlines
Thu 10/239:40 pmSCL - CHS
1 stop13h 40mLATAM Airlines
Deal found 9/14$704
This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:54 pmCHS - SCL
2 stops16h 56mLATAM Airlines
Thu 10/2312:10 amSCL - CHS
2 stops18h 50mLATAM Airlines
Deal found 9/15$708

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 9/29

1:50 pm-2:45 pm

2 stops23h 55m

Santiago Arturo Merino Benitez

Thu 10/2

3:30 pm-10:59 pm

3 stops32h 29m

$591

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 9/25

12:55 pm-7:00 am

1 stop17h 05m

Santiago Arturo Merino Benitez

Mon 9/29

5:55 pm-11:48 am

2 stops18h 53m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 10/16

12:54 pm-5:45 am

2 stops15h 51m

Santiago Arturo Merino Benitez

Mon 10/20

10:55 pm-5:51 pm

1 stop19h 56m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 10/15

6:40 am-6:45 am

2 stops23h 05m

Santiago Arturo Merino Benitez

Tue 10/21

5:55 pm-10:20 am

2 stops17h 25m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 10/13

8:10 am-5:45 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Wed 10/22

10:55 pm-9:00 pm

1 stop23h 05m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 10/29

12:54 pm-5:50 am

2 stops15h 56m

Santiago Arturo Merino Benitez

Tue 11/4

6:40 am-11:59 pm

2 stops19h 19m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 10/13

9:30 am-5:45 am

2 stops19h 15m

Santiago Arturo Merino Benitez

Mon 10/20

10:55 pm-5:51 pm

1 stop19h 56m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 10/29

11:25 am-5:50 am

2 stops17h 25m

Santiago Arturo Merino Benitez

Wed 11/5

5:15 am-11:59 pm

2 stops20h 44m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Mon 10/13

8:10 am-5:45 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Tue 10/21

8:50 am-11:59 pm

2 stops16h 09m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 10/14

12:54 pm-7:00 am

1 stop17h 06m

Santiago Arturo Merino Benitez

Thu 10/23

8:15 am-11:59 pm

2 stops16h 44m

$664

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 42 results
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Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from South Carolina to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • How long is the flight from South Carolina to Santiago?

    A quick flight from South Carolina to Santiago can take about 14h 14m. LATAM Airlines provides one of the quickest options available for as low as $714. The distance between South Carolina and Santiago is about 4773 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Charleston - Santiago Arturo Merino Benitez and Savannah/Hilton Head - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santiago?

    Currently, April is the cheapest month in which you can book a flight from South Carolina to Santiago (average of $752). Flying from South Carolina to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$920FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$898FlexibilityNo cancel feeOn-time81%

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