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$280+ Cheap flights from Panama to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Panama to San Francisco

Cheapest flights from Panama to San Francisco
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This Justfly.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am
PTY
-
SFO
1 stop9h 20m
Avianca
Fri 9/252:15 pm
SFO
-
PTY
1 stop9h 40m
Avianca
Deal found 2/17$486
This FlightHub deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:30 am
PTY
-
SFO
1 stop9h 20m
Avianca
Sat 4/252:15 pm
SFO
-
PTY
1 stop9h 40m
Avianca
Deal found 2/19$499
This Avianca deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
PTY
-
SFO
1 stop9h 20m
Avianca
Tue 4/1411:55 pm
SFO
-
PTY
2 stops15h 05m
Avianca
Deal found 2/18$500
This Avianca deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:45 am
PTY
-
SFO
2 stops15h 05m
Avianca
Thu 3/511:10 pm
SFO
-
PTY
1 stop8h 20m
Avianca
Deal found 2/17$501
This Justfly.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:50 pm
PTY
-
SFO
1 stop10h 30m
Avianca
Sun 2/2211:10 pm
SFO
-
PTY
1 stop8h 20m
Avianca
Deal found 2/16$504
This Justfly.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:50 pm
PTY
-
SFO
1 stop19h 10m
Avianca
Sat 3/142:35 am
SFO
-
PTY
1 stop14h 20m
Avianca
Deal found 2/16$506
This Avianca deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/179:45 am
PTY
-
SFO
2 stops15h 05m
Avianca
Mon 3/2312:10 am
SFO
-
PTY
2 stops14h 45m
Avianca
Deal found 2/16$511
This Mytrip deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:30 am
PTY
-
SFO
1 stop9h 20m
Avianca
Sun 5/3111:55 pm
SFO
-
PTY
1 stop8h 35m
Avianca
Deal found 2/17$519
This Avianca deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/65:30 am
PTY
-
SFO
1 stop19h 05m
Avianca
Tue 7/147:45 am
SFO
-
PTY
2 stops16h 10m
Avianca
Deal found 2/18$521
This Avianca deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:10 am
PTY
-
SFO
2 stops14h 25m
Avianca
Wed 4/152:15 pm
SFO
-
PTY
1 stop18h 15m
Avianca
Deal found 2/18$524
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:30 am
PTY
-
SFO
1 stop9h 20m
Avianca
Thu 5/212:15 pm
SFO
-
PTY
1 stop9h 40m
Avianca
Deal found 2/16$531

Find flight deals from Panama to San Francisco

Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$499
(FlightHub)

One-way from

$280
(Super.com)

Popular in

February

Cheapest in

August

Average price

$793

Good round-trip deal

$793 or less

Good one-way deal

$344 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.
Search Deals
From Panama to San Francisco
Search Deals
One-way flight from Panama to San Francisco
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Panama to San Francisco.
Search Deals
Price to beat on a one-way flight from Panama to San Francisco.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Panama

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

3:50 pm-11:55 pm

1 stop10h 05m

San Francisco

Tue 4/14

2:15 pm-1:55 am

1 stop9h 40m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 4/30

3:50 pm-11:55 pm

1 stop10h 05m

San Francisco

Mon 5/4

11:55 pm-10:30 am

1 stop8h 35m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 5/12

10:10 am-10:35 pm

2 stops14h 25m

San Francisco

Wed 5/20

2:15 pm-1:55 am

1 stop9h 40m

$501

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 5/9

10:10 am-11:55 pm

2 stops15h 45m

San Francisco

Mon 5/18

2:15 pm-1:55 am

1 stop9h 40m

$501

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 3/8

7:50 pm-1:00 pm

1 stop19h 10m

San Francisco

Sat 3/14

2:35 am-6:55 pm

1 stop14h 20m

$506

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 3/11

7:50 pm-1:00 pm

1 stop19h 10m

San Francisco

Sat 3/14

12:10 am-6:55 pm

1 stop16h 45m

$511

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 3/18

7:50 pm-1:00 pm

1 stop19h 10m

San Francisco

Wed 3/25

2:20 pm-10:30 am

1 stop18h 10m

$511

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 5/1

5:30 am-12:50 pm

1 stop9h 20m

San Francisco

Sun 5/31

11:55 pm-10:30 am

1 stop8h 35m

$519

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 6/1

3:50 pm-6:25 am

2 stops16h 35m

$290

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 3/24

9:45 am-10:50 pm

2 stops15h 05m

$290

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 15 results
1
2

Best time to book a flight from Panama to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Francisco

What is the cheapest month to book a flight from Panama to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Panama to San Francisco (average of $220). Flying from Panama to San Francisco in December is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SFO?

Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 19, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Francisco as you normally would.

Weekly flight availability from Panama to San Francisco

Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 19, 2026.

The most flights from PA0 to SFO are scheduled on a Monday (2 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 19, 2026.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines, United Airlines, and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,552 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.5
Good
1,552 reviews
Copa Airlines
7.5
Good
1,552 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
United Airlines
7.4
Good
9,325 reviews
Copa Airlines
7.5
Good
1,552 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,497 reviews
Copa Airlines
7.5
Good
1,552 reviews

Entertainment

6.8

Food

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Panama?

    If you book a flight to San Francisco from Panama, you will be flying to San Francisco, which is the city’s only airport. San Francisco (SFO) is located 11.8 mi from the center of San Francisco.

  • How popular is this Panama to San Francisco flight route?

    The Panama to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to San Francisco?

    Avianca can get you from Panama to San Francisco in just under 14h 25m. Your travel time can differ by up to . The distance between Panama and San Francisco is about 3318 mi.

  • What are the cheapest airlines to fly from Panama to San Francisco one-way?

    One-way options have recently been found by users for as low as $273 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $344 and United Airlines from $461 one-way.

  • What are the cheapest flights from Panama to San Francisco?

    The cheapest flight price from Panama to San Francisco is $344. On average you can expect to pay $622. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $501.

  • Can I find deals for flights from Panama to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Francisco.

  • Can I find deals for business class flights from Panama to San Francisco?

    Yes. Cheapflights offers flight deals from Panama to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Panama to San Francisco (average of $220). Flying from Panama to San Francisco in December is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Panama to San Francisco

Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$335Average$653FlexibilityNo cancel feeOn-time70%
AviancaCheapest$465Average$535FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$669FlexibilityNo cancel feeOn-time69%

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