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$284+ Cheap flights from Panama to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Panama to San Francisco

Cheapest flights from Panama to San Francisco
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:45 amPTY - SFO
2 stops16h 35mAvianca
Thu 1/111:10 pmSFO - PTY
2 stops22h 30mAvianca
Deal found 12/17$556
This Expedia deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:55 pmPTY - SFO
2 stops24h 05mMultiple Airlines
Tue 12/2311:07 pmSFO - PTY
2 stops38h 48mMultiple Airlines
Deal found 12/16$748
This Cheapflightsfares deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:50 pmPTY - SFO
1 stop10h 30mAvianca
Tue 12/3011:10 pmSFO - PTY
2 stops14h 45mAvianca
Deal found 12/17$775
This Copa Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:27 pmPTY - SFO
Nonstop7h 50mCopa Airlines
Mon 12/2912:36 amSFO - PTY
Nonstop7h 10mCopa Airlines
Deal found 12/16$861
This Travelocity deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:50 pmPTY - SFO
2 stops18h 48mMultiple Airlines
Tue 12/3011:07 pmSFO - PTY
2 stops22h 33mMultiple Airlines
Deal found 12/17$872
This Expedia deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:50 pmPTY - SFO
2 stops45h 10mAvianca
Tue 1/61:20 pmSFO - PTY
1 stop18h 10mAvianca
Deal found 12/17$896
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:55 pmPTY - SFO
1 stop21h 14mAmerican Airlines
Tue 1/610:59 pmSFO - PTY
1 stop11h 28mAmerican Airlines
Deal found 12/17$943
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:53 pmPTY - SFO
2 stops21h 59mAmerican Airlines
Fri 1/25:00 pmSFO - PTY
2 stops17h 53mAmerican Airlines
Deal found 12/16$948

Find flight deals from Panama to San Francisco

Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$500
(Avianca)

One-way from

$284
(FlightHub)

Popular in

March

Cheapest in

August

Average price

$693

Good round-trip deal

$519 or less

Good one-way deal

$519 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.
Search Deals
From Panama to San Francisco
Search Deals
One-way flight from Panama to San Francisco
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Panama to San Francisco.
Search Deals
Price to beat on a one-way flight from Panama to San Francisco.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Panama

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 1/31

3:50 pm-11:20 pm

1 stop10h 30m

San Francisco

Sat 2/7

11:10 pm-10:30 am

1 stop8h 20m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Tue 4/14

2:20 pm-10:25 am

1 stop18h 05m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 1/30

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Thu 2/5

1:35 am-6:55 pm

1 stop14h 20m

$519

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 2/1

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Sun 2/8

11:10 pm-6:55 pm

1 stop16h 45m

$520

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 1/15

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Mon 1/19

1:20 pm-8:50 am

2 stops16h 30m

$586

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

5:53 pm-11:40 pm

Nonstop7h 47m

San Francisco

Mon 4/13

1:23 am-10:27 am

Nonstop7h 04m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 5/31

12:38 pm-6:14 pm

Nonstop7h 36m

San Francisco

Sun 6/21

8:06 pm-5:35 am

Nonstop7h 29m

$689

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 1/29

2:55 am-7:59 pm

3 stops20h 04m

San Francisco

Fri 2/6

1:20 pm-8:50 am

2 stops16h 30m

$692

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 3/24

5:50 pm-1:00 pm

2 stops21h 10m

$286

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 1/19

5:50 pm-9:50 pm

2 stops31h 00m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Francisco

What is the cheapest month to book a flight from Panama to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Panama to San Francisco (average of $213). Flying from Panama to San Francisco in February is currently the most expensive (average of $538). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SFO?

Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to San Francisco in the evening. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight in the morning.

Weekly flight availability from Panama to San Francisco

Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 18, 2025.

The most flights from PA0 to SFO are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines, United Airlines, and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,556 reviews

Food

6.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,556 reviews
Copa Airlines
7.6
Good
1,556 reviews

Food

6.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
9,091 reviews
Copa Airlines
7.6
Good
1,556 reviews

Food

6.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,490 reviews
Copa Airlines
7.6
Good
1,556 reviews

Food

6.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Panama?

    If you book a flight to San Francisco from Panama, you will be flying to San Francisco, which is the city’s only airport. San Francisco (SFO) is located 11.8 mi from the center of San Francisco.

  • How popular is this Panama to San Francisco flight route?

    The Panama to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to San Francisco?

    Avianca can get you from Panama to San Francisco in just under 10h 30m. Your travel time can differ by up to . The distance between Panama and San Francisco is about 3318 mi.

  • What are the cheapest airlines to fly from Panama to San Francisco one-way?

    One-way options have recently been found by users for as low as $273 on Avianca. Other airlines that offer cheap prices include American Airlines from $329 and United Airlines from $425 one-way.

  • What are the cheapest flights from Panama to San Francisco?

    The cheapest flight price from Panama to San Francisco is $299. On average you can expect to pay $999. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $564.

  • Can I find deals for flights from Panama to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Francisco.

  • Can I find deals for business class flights from Panama to San Francisco?

    Yes. Cheapflights offers flight deals from Panama to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Panama to San Francisco (average of $213). Flying from Panama to San Francisco in February is currently the most expensive (average of $538). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Redwood City
Sunnyvale
Santa Clara
San Bruno
Daly City
San Carlos
Vallejo
Hollister
San Ramon
Foster City
Union City
Davis
Emeryville

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to San Francisco

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Top 3 airlines flying from Panama to San Francisco

Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$474Average$534FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$664FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$506Average$652FlexibilityNo cancel feeOn-time70%

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