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$287+ Cheap flights from Panama to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheap flight deals from Panama to San Francisco

Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$500
(Avianca)

One-way from

$287
(Cheapflightsfares)

Popular in

October

Cheapest in

August

Average price

$692

Good round-trip deal

$625 or less

Good one-way deal

$494 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.
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From Panama to San Francisco
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One-way flight from Panama to San Francisco
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Highest demand for flights based on searches. 1% potential increase in price ($10 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama to San Francisco.
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Price to beat on a one-way flight from Panama to San Francisco.
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Find flight deals from Panama to San Francisco

Cheapest flights from Panama to San Francisco
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/122:55 amPTY - SFO
2 stops21h 55mAvianca
lun. 11/171:20 pmSFO - PTY
1 stop18h 10mAvianca
Deal found 10/30$508
This Avianca deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/177:50 pmPTY - SFO
1 stop19h 10mAvianca
sáb. 1/31:35 amSFO - PTY
1 stop14h 20mAvianca
Deal found 10/29$510
This Priceline deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/313:50 pmPTY - SFO
1 stop23h 10mAvianca
dom. 11/211:10 pmSFO - PTY
2 stops30h 40mAvianca
Deal found 10/30$519
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/297:50 pmPTY - SFO
1 stop19h 10mAvianca
jue. 1/11:35 amSFO - PTY
1 stop14h 20mAvianca
Deal found 10/30$531
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/63:50 pmPTY - SFO
1 stop10h 30mMultiple Airlines
lun. 12/82:23 pmSFO - PTY
1 stop11h 57mMultiple Airlines
Deal found 10/29$561
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/209:45 amPTY - SFO
2 stops15h 05mAvianca
jue. 11/271:20 pmSFO - PTY
1 stop18h 10mAvianca
Deal found 10/30$565

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Panama

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

dom. 2/1

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

sáb. 2/28

11:10 pm-4:55 pm

2 stops14h 45m

$510

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

dom. 2/1

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

vie. 2/27

11:10 pm-6:55 pm

1 stop16h 45m

$510

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

sáb. 11/22

5:50 pm-12:00 pm

2 stops21h 10m

San Francisco

sáb. 11/29

11:10 pm-10:30 am

1 stop8h 20m

$630

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

vie. 12/19

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

sáb. 12/27

12:36 am-10:46 am

Nonstop7h 10m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

mié. 12/17

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

sáb. 1/3

12:30 am-7:38 pm

1 stop16h 08m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

dom. 2/1

6:27 pm-11:20 pm

Nonstop7h 53m

San Francisco

jue. 2/26

12:42 am-10:46 am

Nonstop7h 04m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

vie. 2/13

6:27 pm-11:20 pm

Nonstop7h 53m

San Francisco

lun. 2/23

12:42 am-10:46 am

Nonstop7h 04m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

sáb. 12/20

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

vie. 1/2

12:42 am-10:46 am

Nonstop7h 04m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

vie. 2/13

8:55 am-5:54 pm

1 stop11h 59m

San Francisco

lun. 2/23

12:43 am-2:45 pm

1 stop11h 02m

$655

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

lun. 1/19

5:50 pm-11:20 pm

2 stops32h 30m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 14 results
1
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Best time to book a flight from Panama to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Francisco

What is the cheapest month to book a flight from Panama to San Francisco?

Currently, April is the cheapest month in which you can book a flight from Panama to San Francisco (average of $176). Flying from Panama to San Francisco in September is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SFO?

Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to San Francisco in the evening. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated octubre 30, 2025.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines, United Airlines, and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,563 reviews
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,998 reviews
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Panama?

    If you book a flight to San Francisco from Panama, you will be flying to San Francisco, which is the city’s only airport. San Francisco (SFO) is located 11.8 mi from the center of San Francisco.

  • How popular is this Panama to San Francisco flight route?

    The Panama to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to San Francisco?

    Avianca and Copa Airlines can get you from Panama to San Francisco in just under 7h 50m. Your travel time can differ by up to 11h 20m. The distance between Panama and San Francisco is about 3318 mi. This flight may include one or multiple stops.

  • What are the cheapest flights from Panama to San Francisco?

    The cheapest flight price from Panama to San Francisco is $332. On average you can expect to pay $829. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $561.

  • Can I find deals for flights from Panama to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Francisco.

  • Can I find deals for business class flights from Panama to San Francisco?

    Yes. Cheapflights offers flight deals from Panama to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Francisco?

    Currently, April is the cheapest month in which you can book a flight from Panama to San Francisco (average of $176). Flying from Panama to San Francisco in September is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Watsonville
Sunnyvale
Santa Clara
Antioch
Manteca
Vallejo
Hollister
Vacaville
San Bruno
Foster City
Redwood City
Union City
Fairfield
Burlingame
Lodi

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Panama to San Francisco

Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$465Average$535FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$640FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$506Average$634FlexibilityNo cancel feeOn-time70%

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