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$287+ Cheap flights from Panama to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from Panama to San Francisco

Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated septiembre 15, 2025.

Round-trip from

$496
(Mytrip)

One-way from

$287
(Cheapflightsfares)

Popular in

October

Cheapest in

August

Average price

$625

Good round-trip deal

$582 or less

Good one-way deal

$423 or less
From Panama to San Francisco
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One-way flight from Panama to San Francisco
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Highest demand for flights based on searches. 4% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama to San Francisco.
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Price to beat on a one-way flight from Panama to San Francisco.
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Find flight deals from Panama to San Francisco

Cheapest flights from Panama to San Francisco
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Gotogate deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/113:35 pmPTY - SFO
1 stop10h 45mAvianca
mar. 11/181:20 pmSFO - PTY
2 stops16h 30mAvianca
Deal found 9/14$496
This Trip.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/293:35 pmPTY - SFO
1 stop9h 15mAvianca
mar. 11/41:35 amSFO - PTY
1 stop14h 20mAvianca
Deal found 9/13$498
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/2710:05 pmPTY - SFO
2 stops16h 30mAvianca
lun. 10/62:20 pmSFO - PTY
2 stops16h 35mAvianca
Deal found 9/13$499
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:20 amPTY - SFO
2 stops21h 25mAvianca
mar. 10/142:20 pmSFO - PTY
2 stops24h 10mAvianca
Deal found 9/14$502
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/302:55 amPTY - SFO
2 stops21h 55mAvianca
dom. 11/211:10 pmSFO - PTY
1 stop8h 10mAvianca
Deal found 9/14$506
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/119:55 amPTY - SFO
2 stops16h 00mAvianca
sáb. 10/182:20 pmSFO - PTY
2 stops17h 50mAvianca
Deal found 9/15$510
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/293:25 amPTY - SFO
2 stops21h 20mAvianca
mié. 10/82:20 pmSFO - PTY
2 stops16h 35mAvianca
Deal found 9/15$514
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/213:20 amPTY - SFO
2 stops21h 25mAvianca
sáb. 9/2712:05 amSFO - PTY
2 stops22h 05mAvianca
Deal found 9/14$516
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/93:40 pmPTY - SFO
1 stop9h 05mAvianca
vie. 10/242:20 pmSFO - PTY
2 stops24h 10mAvianca
Deal found 9/13$519
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/203:20 amPTY - SFO
2 stops21h 25mAvianca
dom. 9/282:20 pmSFO - PTY
1 stop18h 05mAvianca
Deal found 9/14$522

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.

Fly from

Panama

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

dom. 9/21

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

sáb. 9/27

12:05 am-10:25 am

1 stop32h 20m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

mar. 9/30

10:05 pm-12:35 pm

2 stops16h 30m

San Francisco

mar. 10/7

12:05 am-10:25 am

1 stop32h 20m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

sáb. 10/11

9:55 am-10:45 pm

2 stops14h 50m

San Francisco

mar. 10/14

12:05 am-9:10 pm

2 stops19h 05m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

jue. 11/13

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

dom. 11/16

1:20 pm-10:20 am

1 stop18h 00m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

sáb. 9/27

10:05 pm-12:35 pm

2 stops16h 30m

San Francisco

lun. 10/6

2:20 pm-8:55 am

2 stops16h 35m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

vie. 10/31

2:55 am-10:50 pm

2 stops21h 55m

San Francisco

mar. 11/4

1:35 am-8:50 am

2 stops28h 15m

$502

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

lun. 11/10

3:35 pm-9:50 pm

1 stop9h 15m

San Francisco

lun. 11/17

1:20 pm-10:20 am

1 stop18h 00m

$512

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

sáb. 11/1

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

sáb. 11/29

1:35 am-6:55 pm

1 stop14h 20m

$575

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

dom. 10/5

3:40 pm-10:45 pm

1 stop9h 05m

$287

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

lun. 10/13

3:25 am-11:55 pm

2 stops22h 30m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 16 results
1
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Best time to book a flight from Panama to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Francisco

What is the cheapest month to book a flight from Panama to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama to San Francisco (average of $276). Flying from Panama to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SFO?

Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to San Francisco in the morning. If you’re flexible enough to do this you can expect to save up to 24% on your trip compared to booking a flight at noon.

Weekly flight availability from Panama to San Francisco

Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated septiembre 15, 2025.

The most flights from PA0 to SFO are scheduled on a Monday (4 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (3 on average).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated septiembre 15, 2025.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines, United Airlines, and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Comfort

7.4

Food

6.8

Entertainment

6.8

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Comfort

7.4

Food

6.8

Entertainment

6.8

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,929 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Comfort

7.4

Food

6.8

Entertainment

6.8

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Comfort

7.4

Food

6.8

Entertainment

6.8

Overall

7.6

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Panama?

    If you book a flight to San Francisco from Panama, you will be flying to San Francisco, which is the city’s only airport. San Francisco (SFO) is located 11.8 mi from the center of San Francisco.

  • How popular is this Panama to San Francisco flight route?

    The Panama to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama to San Francisco?

    Avianca can get you from Panama to San Francisco in just under 9h 05m. Your travel time can differ by up to . The distance between Panama and San Francisco is about 3318 mi.

  • What are the cheapest flights from Panama to San Francisco?

    The cheapest flight price from Panama to San Francisco is $348. On average you can expect to pay $892. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $499.

  • Can I find deals for flights from Panama to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Francisco.

  • Can I find deals for business class flights from Panama to San Francisco?

    Yes. Cheapflights offers flight deals from Panama to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Panama to San Francisco (average of $276). Flying from Panama to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Panama to San Francisco

Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$366Average$631FlexibilityNo cancel feeOn-time70%
AviancaCheapest$474Average$584FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$633FlexibilityNo cancel feeOn-time69%

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