$105+ Cheap flights from Missouri to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SFO
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to San Francisco
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Cheapest flights from Missouri to San FranciscoExplore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:43 pm -
1 stop16h 34m
Mon 11/96:02 am -
1 stop11h 45m
Deal found 9/13![Frontier logo]()
$262
This Frontier deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:43 pm -
1 stop5h 32m
Tue 10/2712:20 pm -
1 stop5h 27m
Deal found 9/12![Frontier logo]()
$318
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:15 am -
Nonstop3h 52m
Sat 10/1710:53 am -
Nonstop3h 31m
Deal found 9/14![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:43 pm -
1 stop5h 32m
Tue 10/274:57 pm -
2 stops24h 50m
Deal found 9/12![Frontier logo]()
$341
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:43 pm -
1 stop16h 22m
Mon 10/197:13 pm -
1 stop22h 35m
Deal found 9/13![Frontier logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:43 pm -
1 stop5h 32m
Sat 10/173:21 pm -
1 stop6h 38m
Deal found 9/13![Multiple Airlines logo]()
$343
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:32 pm -
1 stop5h 42m
Mon 10/56:04 am -
1 stop11h 33m
Deal found 9/14![Frontier logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:43 pm -
1 stop5h 32m
Tue 10/2011:22 am -
2 stops30h 26m
Deal found 9/14![Frontier logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:53 pm -
2 stops9h 45m
Sun 10/257:59 pm -
1 stop13h 59m
Deal found 9/12![Frontier logo]()
$346
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:05 pm -
2 stops9h 00m
Fri 10/3011:45 am -
1 stop7h 35m
Deal found 9/13![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:00 pm -
1 stop8h 57m
Fri 10/1611:36 pm -
1 stop8h 22m
Deal found 9/11![American Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:53 pm -
1 stop6h 14m
Tue 10/274:57 pm -
2 stops24h 50m
Deal found 9/12![Frontier logo]()
$348
Best flights from Missouri to San FranciscoDiscover carefully curated flight deals from Missouri to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Missouri to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:38 am -
Nonstop3h 52m
Thu 10/154:15 pm -
Nonstop3h 37m
Deal found 9/10![United Airlines logo]()
$400
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/275:13 pm -
1 stop8h 15m
Mon 3/156:45 am -
1 stop7h 58m
Deal found 9/11![American Airlines logo]()
$403
This Alaska Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:02 am -
1 stop8h 24m
Tue 11/105:42 pm -
1 stop18h 43m
Deal found 9/10![Alaska Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:35 am -
2 stops7h 40m
Wed 10/1412:15 pm -
2 stops9h 00m
Deal found 9/9![Southwest logo]()
$558
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:35 pm -
2 stops10h 21m
Sun 11/15:50 am -
1 stop5h 42m
Deal found 9/14![Delta logo]()
$562
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:15 am -
1 stop7h 05m
Sun 10/412:35 am -
1 stop8h 04m
Deal found 9/13![United Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:03 pm -
Nonstop4h 07m
Fri 11/2711:33 am -
Nonstop3h 34m
Deal found 9/11![United Airlines logo]()
$407
This Alaska Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:02 am -
2 stops15h 31m
Wed 10/219:43 am -
1 stop12h 16m
Deal found 9/12![Alaska Airlines logo]()
$478
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
Nonstop4h 05m
Sun 12/612:35 pm -
Nonstop3h 33m
Deal found 9/11![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:59 am -
2 stops9h 03m
Sun 10/47:00 am -
1 stop9h 02m
Deal found 9/14![American Airlines logo]()
$506
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:08 am -
Nonstop4h 22m
Mon 10/1211:59 pm -
1 stop8h 11m
Deal found 9/14![United Airlines logo]()
$410
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:15 am -
Nonstop3h 52m
Thu 10/226:15 am -
1 stop8h 07m
Deal found 9/11![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:39 pm -
1 stop8h 30m
Fri 10/3012:15 pm -
Nonstop3h 50m
Deal found 9/14![United Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:22 am -
1 stop9h 32m
Sat 10/1010:53 am -
Nonstop3h 31m
Deal found 9/10![United Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:10 am -
1 stop7h 55m
Mon 10/512:45 pm -
Nonstop3h 58m
Deal found 9/10![United Airlines logo]()
$436
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
Nonstop4h 02m
Mon 11/164:51 pm -
Nonstop3h 24m
Deal found 9/12![United Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:15 am -
Nonstop3h 52m
Tue 10/2010:53 am -
Nonstop3h 31m
Deal found 9/14![United Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:00 am -
Nonstop4h 02m
Mon 11/1611:33 am -
Nonstop3h 34m
Deal found 9/12![United Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:08 am -
Nonstop4h 22m
Wed 10/2112:45 pm -
Nonstop3h 58m
Deal found 9/14![United Airlines logo]()
$451
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:02 am -
1 stop10h 33m
Tue 1/1212:40 am -
1 stop9h 39m
Deal found 9/10![United Airlines logo]()
$454
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:00 am -
Nonstop4h 02m
Tue 11/244:51 pm -
Nonstop3h 24m
Deal found 9/10![United Airlines logo]()
$461
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/309:00 am -
1 stop6h 09m
Wed 2/311:10 pm -
1 stop9h 45m
Deal found 9/14![United Airlines logo]()
$468
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:01 am -
1 stop9h 29m
Sat 11/1411:30 pm -
1 stop8h 29m
Deal found 9/13![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:55 pm -
1 stop7h 37m
Tue 12/85:00 am -
1 stop5h 51m
Deal found 9/13![United Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:08 am -
Nonstop4h 22m
Fri 10/1612:45 pm -
Nonstop3h 58m
Deal found 9/11![United Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:11 pm -
1 stop5h 40m
Mon 10/124:15 pm -
Nonstop3h 37m
Deal found 9/12![United Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:30 pm -
1 stop5h 53m
Sun 10/2510:45 pm -
1 stop9h 14m
Deal found 9/11![United Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:19 pm -
1 stop7h 56m
Sat 10/310:42 pm -
1 stop9h 57m
Deal found 9/14![United Airlines logo]()
$538
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:00 am -
Nonstop4h 36m
Sat 11/710:45 pm -
1 stop8h 10m
Deal found 9/11![United Airlines logo]()
$538
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:15 am -
1 stop10h 17m
Tue 10/2010:42 pm -
1 stop9h 57m
Deal found 9/13![United Airlines logo]()
$548
Last-minute flights from Missouri to San FranciscoDiscover last-minute flight deals from Missouri to San Francisco. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to San Francisco. Data last updated September 15, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2710:30 pm -
1 stop11h 44m
Fri 10/211:53 am -
1 stop5h 44m
Deal found 9/11![Frontier logo]()
$349
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:32 pm -
1 stop5h 42m
Mon 10/56:04 am -
1 stop11h 33m
Deal found 9/14![Frontier logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:43 pm -
1 stop5h 32m
Sat 10/173:21 pm -
1 stop6h 38m
Deal found 9/13![Multiple Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:00 pm -
1 stop8h 57m
Fri 10/1611:36 pm -
1 stop8h 22m
Deal found 9/11![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:15 am -
Nonstop3h 52m
Sat 10/1710:53 am -
Nonstop3h 31m
Deal found 9/14![United Airlines logo]()
$339
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:43 pm -
1 stop16h 22m
Mon 10/197:13 pm -
1 stop22h 35m
Deal found 9/13![Frontier logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:43 pm -
1 stop5h 32m
Tue 10/2011:22 am -
2 stops30h 26m
Deal found 9/14![Frontier logo]()
$345
This Frontier deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:43 pm -
1 stop5h 32m
Tue 10/2712:20 pm -
1 stop5h 27m
Deal found 9/12![Frontier logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:53 pm -
2 stops9h 45m
Sun 10/257:59 pm -
1 stop13h 59m
Deal found 9/12![Frontier logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:53 pm -
1 stop6h 14m
Tue 10/274:57 pm -
2 stops24h 50m
Deal found 9/12![Frontier logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:43 pm -
1 stop5h 32m
Tue 10/274:57 pm -
2 stops24h 50m
Deal found 9/12![Frontier logo]()
$341
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:05 pm -
2 stops9h 00m
Fri 10/3011:45 am -
1 stop7h 35m
Deal found 9/13![Southwest logo]()
$347
One-way flights from Missouri to San FranciscoSearch for one-way flight options from Missouri to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Missouri to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This Super.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:43 pm -
1 stop5h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$105
This Super.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:43 pm -
1 stop5h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$107
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:43 pm -
1 stop5h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$108
This Alaska Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:14 pm -
1 stop17h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Alaska Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:43 pm -
2 stops25h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Frontier logo]()
$118
This Super.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:32 pm -
1 stop5h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Frontier logo]()
$119
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:35 pm -
Nonstop3h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$120
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:32 pm -
1 stop5h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Frontier logo]()
$121
This CheapOair deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:43 pm -
1 stop5h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:43 pm -
2 stops25h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$124
This Super.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/148:36 pm -
1 stop25h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:26 pm -
2 stops33h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Frontier logo]()
$177
Find flight deals from Missouri to San Francisco
Keep the following information in mind while searching for Missouri to San Francisco flight deals. Data was last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $262 (Kiwi.com) |
One-way from | $105 (Super.com) |
Popular in | March |
Cheapest in | November |
Average price | $497 |
Good round-trip deal | $439 or less |
Good one-way deal | $269 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Missouri to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Tue 11/10
8:43 pm-12:20 am
1 stop5h 37m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$108
Quickest round-trip
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Sat 10/17
8:15 am-10:07 am
Nonstop3h 52m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$120
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Tue 10/13
7:38 am-9:30 am
Nonstop3h 52m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$164
St. LouisSan Francisco
STL Lambert-St Louis - SFO San Francisco
STLSFO
Lambert-St Louis
Tue 10/13
7:02 am-4:16 pm
2 stops11h 14m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$194
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Tue 10/6
11:57 am-7:31 pm
2 stops9h 34m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$209
St. LouisSan Francisco
STL Lambert-St Louis - SFO San Francisco
STLSFO
Lambert-St Louis
Thu 10/29
8:00 am-10:36 am
Nonstop4h 36m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$209
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Sat 10/10
8:15 am-10:07 am
Nonstop3h 52m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$214
Kansas CitySan Francisco
MCI Kansas City - SFO San Francisco
MCISFO
Kansas City
Wed 10/7
8:15 am-10:07 am
Nonstop3h 52m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$214
St. LouisSan Francisco
STL Lambert-St Louis - SFO San Francisco
STLSFO
Lambert-St Louis
Sat 12/12
7:08 am-5:16 pm
2 stops12h 08m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$217
St. LouisSan Francisco
STL Lambert-St Louis - SFO San Francisco
STLSFO
Lambert-St Louis
Thu 10/8
7:00 pm-11:56 pm
1 stop6h 56m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$219
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Missouri with our price prediction graph.
MCI-SFO
STL-SFO
COU-SFO
JLN-SFO
SGF-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to San Francisco
USMO-SFO
MCI-SFO
STL-SFO
COU-SFO
JLN-SFO
What is the cheapest month to book a flight from Missouri to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $387). Flying from Missouri to San Francisco in March is currently the most expensive (average of $503). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SFO?
Find hourly flight availability from Missouri to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2026.
It’s typically best to fly out from Missouri to San Francisco in the morning. Doing so could potentially save you 17% on the flight price compared to flying in the evening, which is usually more expensive.
How much does it cost to fly round-trip from Missouri to San Francisco?
Airfare is below average for this route at the moment.
Missouri to San Francisco flights typically cost between $397 and $616 in October.The cheapest round-trip price found within the last 5 days was $378 on Delta (Oct 31-Nov 3).
How far ahead should I book a flight from Missouri to San Francisco?
Booking 61 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Hayward
Cupertino
Newark
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to San Francisco by cabin class
Find flights from Missouri to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and San Francisco flights
Browse other Missouri and San Francisco flight options. Last updated on September 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
Missouri to San Francisco flights
Consider these flights traveling from Missouri to San Francisco.
Top 6 airlines flying from Missouri to San Francisco
Discover the top 6 airlines that operate flights from Missouri to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$144 | Average$281 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$182 | Average$456 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$397 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$322 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$278 | Average$462 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$284 | Average$490 | FlexibilityNo cancel fee | On-time63% |