What is the cheapest airline to fly from Florence, South Carolina to San Francisco round-trip?

Our cheapest airline available from Florence, South Carolina to San Francisco is American Airlines. Our recent data shows that you can find tickets from as low as $357 on this airline.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from FLO to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florence, South Carolina to San Francisco as you normally would.

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florence to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

Can I find deals for business class flights from Florence to San Francisco?

Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$209+ Flights from Florence, SC to San Francisco

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Cheap flight deals from Florence to San Francisco

Round-trip from	$357 (American Airlines)
One-way from	$209 (American Airlines)

From Florence to San Francisco

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One-way flight from Florence to San Francisco

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Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Tue 11/112:34 pmFLO - SFO

1 stop9h 08mAmerican Airlines

Wed 11/2610:46 pmSFO - FLO

1 stop8h 27mAmerican Airlines

Deal found 6/30

$357

Best flights from Florence to San Francisco
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Tue 11/112:34 pmFLO - SFO

1 stop9h 08mAmerican Airlines

Wed 11/2610:46 pmSFO - FLO

1 stop8h 27mAmerican Airlines

Deal found 6/30

$357

Last-minute flights from Florence to San Francisco
Discover last-minute flight deals from Florence to San Francisco. Data last updated July 1, 2025 and is based on user searches.

Fri 8/12:34 pmFLO - SFO

1 stop10h 08mAmerican Airlines

Sun 8/312:55 amSFO - FLO

2 stops10h 14mAmerican Airlines

Deal found 7/1

$422

One-way flights from Florence to San Francisco
Search for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Mon 8/183:30 pmFLO - SFO

1 stop9h 11mAmerican Airlines

Deal found 7/1

$209

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 11/11

2:34 pm-8:42 pm

1 stop9h 08m

San Francisco

Wed 11/26

10:46 pm-10:13 am

1 stop8h 27m

$357

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 8/18

3:30 pm-9:41 pm

1 stop9h 11m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

What is the cheapest airline to fly from Florence, South Carolina to San Francisco round-trip?
Our cheapest airline available from Florence, South Carolina to San Francisco is American Airlines. Our recent data shows that you can find tickets from as low as $357 on this airline.
Can I find deals for flights from Florence to San Francisco that include hotel bookings?
Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florence to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.
Can I find deals for business class flights from Florence to San Francisco?
Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Roseville

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Santa Cruz

Turlock

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Watsonville

Fairfield

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Hollister

Milpitas

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Newark

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Hayward

Daly City

Campbell

Capitola

Foster City

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Florence to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$326	Average$416	FlexibilityNo cancel fee	On-time71%

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$209+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florence to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florence to San Francisco

Round-trip from

One-way from

Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Florence, South Carolina to San Francisco round-trip?

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

How can I find direct flights from Florence to San Francisco?

Can I find deals for business class flights from Florence to San Francisco?

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Traveling to a place near Florence?

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Alternative routes for Florence to San Francisco

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Top airline flying from Florence to San Francisco

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Book with Flexibility

Travel Smart

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.