What is the cheapest airline to fly from Columbia, Missouri to San Francisco round-trip?

Currently priced at $345, American Airlines will fly you from Columbia, Missouri to San Francisco and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. American Airlines is 37% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Columbia, Missouri to San Francisco?

Travelers seeking maximum savings on their Columbia, Missouri to San Francisco flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest day to fly round-trip from Columbia, Missouri to San Francisco?

Departing on a Friday is a good option for securing a great price. You can expect to save up to 31% when planning your travel around this day of the week.

What is the cheapest month to fly from Columbia, Missouri to San Francisco?

April is one of the best times of the year to fly to San Francisco from Columbia, Missouri. Prices for April average $551 per person but you can even find prices for as low as $353. The most expensive prices can be found in the month of August. Opting for a April flight can save you 55% on your journey compared to booking in August

Can I find deals for flights from Columbia to San Francisco that include hotel bookings?

Yes. In addition to deals on Columbia to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbia to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to San Francisco.

Can I find deals for business class flights from Columbia to San Francisco?

Yes. Cheapflights offers flight deals from Columbia to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$345+ Flights from Columbia, MO to San Francisco

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Cheap flight deals from Columbia to San Francisco

Round-trip from	$345 (American Airlines)
Popular in	August
Cheapest in	April
Average price	$558

From Columbia Regional to San Francisco

Search Deals

Highest demand for flights based on searches. 14% potential increase in price ($95 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($28 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Find flight deals from Columbia to San Francisco

Cheapest flights from Columbia to San Francisco
Explore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Sat 8/166:15 amCOU - SFO

1 stop6h 49mAmerican Airlines

Sat 8/238:00 amSFO - COU

1 stop6h 38mAmerican Airlines

Deal found 7/1

$345

Best flights from Columbia to San Francisco
Discover carefully curated flight deals from Columbia to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 3, 2025.

Sat 8/166:15 amCOU - SFO

1 stop6h 49mAmerican Airlines

Sat 8/238:00 amSFO - COU

1 stop6h 38mAmerican Airlines

Deal found 7/1

$345

Last-minute flights from Columbia to San Francisco
Discover last-minute flight deals from Columbia to San Francisco. Data last updated July 3, 2025 and is based on user searches.

Sat 8/166:15 amCOU - SFO

1 stop6h 49mAmerican Airlines

Sat 8/238:00 amSFO - COU

1 stop6h 38mAmerican Airlines

Deal found 7/1

$345

One-way flights from Columbia to San Francisco
Search for one-way flight options from Columbia to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 3, 2025.

Thu 7/175:15 pmCOU - SFO

1 stop8h 53mAmerican Airlines

Deal found 7/1

$443

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaSan Francisco

COU - SFO

COUSFO

Columbia Regional

Sat 8/16

6:15 am-11:04 am

1 stop6h 49m

San Francisco

Sat 8/23

8:00 am-4:38 pm

1 stop6h 38m

$345

ColumbiaSan Francisco

COU - SFO

COUSFO

Columbia Regional

Thu 7/17

5:15 pm-12:08 am

1 stop8h 53m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Columbia to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Columbia with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to San Francisco

What is the cheapest month to book a flight from Columbia, Missouri to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to San Francisco (average of $276). Flying from Columbia, Missouri to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from COU to SFO?

Unlike in the afternoon, when flights are generally more expensive, you can save up to 13% on flights from Columbia, Missouri to San Francisco by exploring options for tickets in the morning.

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with American Airlines from Columbia to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

8.0

Excellent

Douglas,Sep 2023

RNO - LAX

There was a maintenance issue that caused us to depart over 1 hour late.

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

8.0

Excellent

Douglas,Sep 2023

RNO - LAX

There was a maintenance issue that caused us to depart over 1 hour late.

Related info for your journey

What is the cheapest airline to fly from Columbia, Missouri to San Francisco round-trip?
Currently priced at $345, American Airlines will fly you from Columbia, Missouri to San Francisco and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. American Airlines is 37% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Columbia to San Francisco that include hotel bookings?
Yes. In addition to deals on Columbia to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbia to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to San Francisco.
Can I find deals for business class flights from Columbia to San Francisco?
Yes. Cheapflights offers flight deals from Columbia to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbia, Missouri to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to San Francisco (average of $276). Flying from Columbia, Missouri to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Columbia to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$377	Average$529	FlexibilityNo cancel fee	On-time71%

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$345+ Cheap flights from Columbia, MO to San Francisco (COU - SFO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbia to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Columbia to San Francisco

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Columbia to San Francisco

Cheapest flights from Columbia to San FranciscoExplore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Explore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to San Francisco that are best for you.

Best time to book a flight from Columbia to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Columbia with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbia to San Francisco

What is the cheapest month to book a flight from Columbia, Missouri to San Francisco?

What is the cheapest time of day to fly from COU to SFO?

Find hourly flight availability from Columbia to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Reviews of airlines servicing San Francisco

Get a feel of what it's like to fly with American Airlines from Columbia to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbia to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Columbia, Missouri to San Francisco round-trip?

Can I find deals for flights from Columbia to San Francisco that include hotel bookings?

How can I find direct flights from Columbia to San Francisco?

Can I find deals for business class flights from Columbia to San Francisco?

What is the cheapest month to book a flight from Columbia, Missouri to San Francisco?

Traveling to a place near Columbia?

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Alternative routes for Columbia to San Francisco

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Top airline flying from Columbia to San Francisco

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Cheapest flights from Columbia to San Francisco
Explore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.