HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$89+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — SAN
Jul 27 — Aug 31
Mon 7/27
Mon 8/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.

This CheapOair deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:58 pm
STL
-
SAN
1 stop5h 53m
Frontier
Mon 8/318:59 pm
SAN
-
STL
1 stop18h 51m
Frontier
Deal found 6/22$268
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:32 pm
MCI
-
SAN
2 stops9h 27m
Frontier
Thu 8/208:59 pm
SAN
-
MCI
1 stop17h 03m
Frontier
Deal found 6/22$274
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:35 am
STL
-
SAN
2 stops31h 06m
Frontier
Tue 10/136:25 am
SAN
-
STL
1 stop10h 50m
Frontier
Deal found 6/24$274
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:32 pm
MCI
-
SAN
1 stop23h 36m
Frontier
Wed 8/53:03 pm
SAN
-
MCI
1 stop22h 44m
Frontier
Deal found 6/26$276
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:19 pm
MCI
-
SAN
1 stop8h 07m
American Airlines
Fri 7/314:32 pm
SAN
-
MCI
1 stop5h 51m
American Airlines
Deal found 6/22$277
This Frontier deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:08 pm
STL
-
SAN
1 stop5h 43m
Frontier
Sat 7/186:35 am
SAN
-
STL
1 stop6h 21m
Frontier
Deal found 6/25$278
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:17 pm
MCI
-
SAN
1 stop27h 24m
Frontier
Sun 9/2710:36 am
SAN
-
MCI
1 stop24h 46m
Frontier
Deal found 6/23$279
This CheapOair deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:58 pm
MCI
-
SAN
1 stop8h 53m
Frontier
Thu 7/98:51 pm
SAN
-
MCI
1 stop16h 56m
Frontier
Deal found 6/23$280
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/161:45 pm
MCI
-
SAN
1 stop12h 06m
Frontier
Thu 7/308:51 pm
SAN
-
MCI
1 stop16h 56m
Frontier
Deal found 6/25$281
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/104:57 pm
STL
-
SAN
2 stops28h 03m
Frontier
Thu 8/138:51 pm
SAN
-
STL
1 stop19h 24m
Frontier
Deal found 6/24$281
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:05 pm
MCI
-
SAN
1 stop5h 15m
Southwest
Tue 7/141:15 pm
SAN
-
MCI
2 stops6h 50m
Southwest
Deal found 6/22$282
This Booking.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/164:32 pm
MCI
-
SAN
1 stop5h 34m
Frontier
Wed 8/193:45 pm
SAN
-
MCI
1 stop19h 35m
Frontier
Deal found 6/26$283

Find flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated June 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$274
(Kiwi.com)

One-way from

$89
(Trip.com)

Popular in

December

Cheapest in

September

Average price

$419

Good round-trip deal

$488 or less

Good one-way deal

$225 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 8/7

5:18 pm-11:00 pm

1 stop7h 42m

San Diego

Mon 8/10

9:30 pm-9:19 am

1 stop9h 49m

$277

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 8/27

5:10 am-9:05 am

1 stop5h 55m

San Diego

Sun 8/30

10:40 pm-8:39 am

1 stop7h 59m

$297

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Thu 9/10

6:49 pm-11:55 pm

1 stop7h 06m

San Diego

Sat 9/19

10:46 pm-10:08 am

1 stop9h 22m

$329

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 8/13

7:20 am-8:35 am

Nonstop3h 15m

San Diego

Thu 8/20

2:55 pm-11:05 pm

1 stop6h 10m

$336

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 9/10

7:20 am-8:35 am

Nonstop3h 15m

San Diego

Mon 9/14

3:55 pm-11:15 pm

1 stop5h 20m

$347

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Fri 9/4

10:55 am-7:55 pm

2 stops11h 00m

San Diego

Thu 9/10

2:15 pm-10:55 pm

1 stop6h 40m

$355

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 8/25

6:35 am-1:19 pm

1 stop8h 44m

San Diego

Wed 8/26

6:55 am-5:10 pm

1 stop8h 15m

$377

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 9/24

7:20 am-8:35 am

Nonstop3h 15m

San Diego

Sat 9/26

8:50 am-5:15 pm

1 stop6h 25m

$383

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Thu 10/1

5:34 pm-10:55 pm

1 stop7h 21m

San Diego

Sun 10/4

12:52 pm-10:08 pm

1 stop7h 16m

$394

JoplinSan Diego

JLN - SAN

JLNSAN

Joplin

Thu 7/9

1:57 pm-5:20 pm

1 stop5h 23m

San Diego

Mon 7/13

4:01 pm-11:44 pm

1 stop5h 43m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/24

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $56). Flying from Missouri to San Diego in May is currently the most expensive (average of $155). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 27, 2026.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 20% versus a flight at noon.

How much does it cost to fly round-trip from Missouri to San Diego?

How far ahead should I book a flight from Missouri to San Diego?

Booking 35 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on June 27, 2026.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 4 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    Delta, United Airlines, and American Airlines can get you from Missouri to San Diego in just under 5h 55m. Your travel time can differ by up to 1h 47m. The distance from Missouri to San Diego is about 1553 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $484, our data indicates the cheapest price to be $199. The most popular route (Kansas City - San Diego), is priced around $217.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $56). Flying from Missouri to San Diego in May is currently the most expensive (average of $155). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
National City
Chula Vista
Poway
Coronado
La Mesa
Santee
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Newark to San Francisco flights
John F Kennedy Intl to San Francisco flights
LaGuardia to San Francisco flights
Newark to Los Angeles flights
John F Kennedy Intl to Los Angeles flights
Seattle to Los Angeles flights
Dallas/Fort Worth to Las Vegas flights
Dallas/Fort Worth to Los Angeles flights
John F Kennedy Intl to Las Vegas flights
Newark to Las Vegas flights
Seattle to Las Vegas flights
Los Angeles to Las Vegas flights
Stewart to San Francisco flights
Seattle to Ontario flights
San Francisco to Las Vegas flights
Hobby to Las Vegas flights
Atlanta to Las Vegas flights
Santa Rosa to Las Vegas flights
Hobby to Los Angeles flights
O'Hare Intl to Los Angeles flights
San Francisco to Los Angeles flights
O'Hare Intl to Las Vegas flights
LaGuardia to Los Angeles flights
Dulles Intl to Las Vegas flights
George Bush Intcntl to Las Vegas flights
John F Kennedy Intl to Ontario flights
Los Angeles to San Francisco flights
Seattle to Santa Ana flights
Detroit to Las Vegas flights
Baltimore to Los Angeles flights
Reagan-National to Los Angeles flights
Seattle to San Francisco flights
Reagan-National to Las Vegas flights
O'Hare Intl to San Francisco flights
Dallas/Fort Worth to San Francisco flights
George Bush Intcntl to Los Angeles flights
San Francisco to Ontario flights
Orlando to Las Vegas flights
Boston to Las Vegas flights
Dallas/Fort Worth to Ontario flights
Dulles Intl to Los Angeles flights
LaGuardia to Las Vegas flights
Denver to Las Vegas flights
Ontario to San Francisco flights
Dallas/Fort Worth to San Diego flights
Baltimore to Las Vegas flights
Atlanta to Los Angeles flights
Newark to San Jose flights
Midway to Las Vegas flights
San Francisco to San Diego flights

Top 6 airlines flying from Missouri to San Diego

Discover the top 6 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$96Average$237FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$182Average$347FlexibilityNo cancel feeOn-time69%
DeltaCheapest$186Average$311FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$203Average$432FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$261Average$420FlexibilityNo cancel feeOn-time63%
Alaska AirlinesCheapest$418Average$438FlexibilityNo cancel feeOn-time75%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.