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San Diego

$82+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Jun 10 — Jun 171
Wed 6/10
Wed 6/17
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.

This CheapOair deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/162:52 pm
STL
-
SAN
1 stop6h 39m
Frontier
Sun 8/239:53 pm
SAN
-
STL
1 stop19h 43m
Frontier
Deal found 5/10$260
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:08 pm
STL
-
SAN
1 stop14h 57m
Frontier
Sun 8/168:29 pm
SAN
-
STL
1 stop15h 38m
Frontier
Deal found 5/7$261
This Expedia deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:06 pm
STL
-
SAN
1 stop13h 42m
Frontier
Mon 6/156:25 am
SAN
-
STL
1 stop9h 53m
Frontier
Deal found 5/11$264
This Trip.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/229:06 pm
STL
-
SAN
1 stop26h 06m
Frontier
Sat 5/306:25 am
SAN
-
STL
1 stop11h 06m
Frontier
Deal found 5/7$266
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:21 am
STL
-
SAN
1 stop8h 56m
Delta
Fri 7/105:01 pm
SAN
-
STL
1 stop5h 40m
Delta
Deal found 5/6$267
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:22 pm
STL
-
SAN
1 stop8h 17m
American Airlines
Wed 5/273:10 pm
SAN
-
STL
1 stop6h 49m
American Airlines
Deal found 5/7$268
This Gotogate deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/121:45 pm
MCI
-
SAN
1 stop20h 57m
Frontier
Mon 6/1510:04 am
SAN
-
MCI
1 stop24h 56m
Frontier
Deal found 5/6$270
This Frontier deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:10 pm
STL
-
SAN
1 stop5h 49m
Frontier
Sun 9/139:19 am
SAN
-
STL
1 stop6h 25m
Frontier
Deal found 5/10$270
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:52 pm
STL
-
SAN
2 stops30h 06m
Frontier
Wed 8/510:04 am
SAN
-
STL
1 stop7h 19m
Frontier
Deal found 5/6$271
This Booking.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:34 pm
MCI
-
SAN
1 stop11h 16m
Frontier
Sun 6/76:25 am
SAN
-
MCI
1 stop5h 24m
Frontier
Deal found 5/6$272
This Booking.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:38 pm
STL
-
SAN
1 stop6h 15m
Frontier
Thu 6/2510:04 am
SAN
-
STL
1 stop6h 49m
Frontier
Deal found 5/7$272
This Expedia deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
-
SAN
1 stop20h 08m
Multiple Airlines
Sat 6/67:00 am
SAN
-
MCI
1 stop7h 57m
Multiple Airlines
Deal found 5/7$274

Find flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated May 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$260
(CheapOair)

One-way from

$82
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$381

Good round-trip deal

$478 or less

Good one-way deal

$253 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 7/24

6:30 pm-9:05 pm

1 stop4h 35m

San Diego

Mon 7/27

6:55 pm-1:30 am

1 stop4h 35m

$272

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 7/13

6:00 pm-11:50 pm

1 stop7h 50m

San Diego

Fri 7/17

10:15 pm-9:44 am

1 stop9h 29m

$277

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 9/25

6:00 am-9:50 am

1 stop5h 50m

San Diego

Mon 9/28

2:15 pm-11:15 pm

1 stop7h 00m

$277

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 6/11

8:15 pm-11:25 pm

1 stop5h 10m

San Diego

Fri 6/12

2:45 pm-11:20 pm

2 stops6h 35m

$282

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 7/15

3:55 pm-7:17 pm

1 stop5h 22m

San Diego

Fri 7/17

10:15 pm-9:44 am

1 stop9h 29m

$298

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Thu 10/1

5:00 am-10:11 am

1 stop7h 11m

San Diego

Mon 10/5

2:09 pm-12:33 am

1 stop8h 24m

$318

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Thu 7/16

6:32 pm-11:26 pm

1 stop6h 54m

San Diego

Mon 7/20

10:45 pm-10:01 am

1 stop9h 16m

$328

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 6/29

6:30 pm-9:05 pm

1 stop4h 35m

San Diego

Tue 7/7

8:45 am-5:00 pm

2 stops6h 15m

$329

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Sat 8/22

11:38 am-7:22 pm

1 stop9h 44m

San Diego

Tue 8/25

6:15 am-6:13 pm

1 stop9h 58m

$339

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 6/12

1:45 pm-11:53 pm

1 stop12h 08m

San Diego

Mon 6/15

9:43 am-1:00 pm

2 stops25h 17m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/6

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

How far ahead should I book a flight from Missouri to San Diego?

Booking 63 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $56). Flying from Missouri to San Diego in October is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 11, 2026.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight at noon.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on May 9, 2026.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Missouri to San Diego?

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 4 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    Southwest, Delta, and United Airlines can get you from Missouri to San Diego in just under 4h 35m. Your travel time can differ by up to 2h 36m. The distance from Missouri to San Diego is about 1330 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Kansas City - San Diego or Springfield-Branson - San Diego, Lambert-St Louis - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $445, our data indicates the cheapest price to be $224. The most popular route (Lambert-St Louis - San Diego), is priced around $224.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $56). Flying from Missouri to San Diego in October is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$69Average$203FlexibilityNo cancel feeOn-time65%
FrontierCheapest$88Average$230FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$124Average$341FlexibilityNo cancel feeOn-time75%
DeltaCheapest$136Average$318FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$182Average$356FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$211Average$421FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$258Average$428FlexibilityNo cancel feeOn-time63%

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