$38+ Cheap flights from Missouri to San Diego (SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Nov 2 — Nov 91
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to San Diego
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Cheapest flights from Missouri to San DiegoExplore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Tue 11/34:53 pm -
1 stop24h 54m
Deal found 9/29![Frontier logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Mon 11/210:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$111
This Cheapflightsfares deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:43 pm -
1 stop21h 15m
Sat 11/146:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$113
This Frontier deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:43 pm -
1 stop5h 14m
Sat 10/316:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$120
This Frontier deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:43 pm -
1 stop5h 14m
Tue 11/36:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Tue 11/310:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Mon 11/210:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:43 pm -
2 stops15h 20m
Sat 10/316:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$129
This Mytrip deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:26 pm -
2 stops33h 31m
Mon 11/26:25 am -
1 stop10h 49m
Deal found 9/30![Frontier logo]()
$297
Best flights from Missouri to San DiegoDiscover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
Discover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:35 pm -
Nonstop3h 30m
Sat 10/316:35 am -
1 stop7h 00m
Deal found 10/1![Southwest logo]()
$307
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:48 pm -
1 stop6h 11m
Mon 11/236:15 am -
1 stop8h 23m
Deal found 9/30![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:01 am -
1 stop8h 26m
Wed 1/64:10 pm -
1 stop5h 34m
Deal found 9/30![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:20 am -
2 stops13h 31m
Mon 11/235:13 pm -
1 stop5h 27m
Deal found 10/1![Delta logo]()
$357
This Alaska Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:04 am -
1 stop9h 19m
Wed 12/96:15 am -
1 stop8h 25m
Deal found 10/2![Alaska Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:35 pm -
Nonstop3h 30m
Wed 10/286:30 am -
1 stop7h 55m
Deal found 9/29![Southwest logo]()
$307
This Booking.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:40 am -
1 stop26h 23m
Sun 11/85:56 pm -
1 stop24h 54m
Deal found 10/2![Multiple Airlines logo]()
$660
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:45 pm -
1 stop5h 40m
Mon 10/266:20 pm -
Nonstop3h 10m
Deal found 9/28![Southwest logo]()
$307
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/25:11 pm -
1 stop7h 45m
Tue 2/97:15 am -
1 stop7h 22m
Deal found 10/1![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop7h 10m
Tue 10/272:08 pm -
1 stop6h 50m
Deal found 9/29![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:31 pm -
1 stop8h 07m
Tue 12/157:20 am -
2 stops12h 08m
Deal found 10/1![Delta logo]()
$386
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:10 am -
2 stops7h 10m
Fri 10/3012:45 pm -
2 stops6h 35m
Deal found 9/29![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop7h 10m
Thu 10/2911:21 am -
2 stops9h 37m
Deal found 9/29![United Airlines logo]()
$422
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:25 pm -
1 stop8h 37m
Sun 10/1812:38 pm -
1 stop7h 41m
Deal found 9/28![Delta logo]()
$429
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:20 am -
Nonstop3h 30m
Tue 10/2710:35 am -
Nonstop3h 05m
Deal found 9/29![Southwest logo]()
$376
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:19 pm -
1 stop9h 22m
Wed 10/2111:19 am -
2 stops9h 36m
Deal found 10/2![United Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:40 am -
1 stop9h 49m
Wed 12/21:36 pm -
1 stop5h 52m
Deal found 10/2![Delta logo]()
$432
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:35 pm -
1 stop6h 35m
Tue 12/82:30 pm -
Nonstop3h 05m
Deal found 9/29![Southwest logo]()
$386
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:00 am -
1 stop6h 17m
Mon 10/194:11 pm -
1 stop5h 31m
Deal found 9/30![United Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:26 pm -
1 stop6h 35m
Sat 11/284:40 pm -
1 stop5h 12m
Deal found 10/3![American Airlines logo]()
$536
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/219:00 am -
2 stops10h 26m
Mon 10/267:41 pm -
2 stops11h 17m
Deal found 9/29![United Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/18:28 am -
1 stop5h 47m
Mon 1/1111:43 am -
1 stop9h 19m
Deal found 9/30![American Airlines logo]()
$561
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:40 pm -
2 stops6h 45m
Thu 12/316:30 am -
1 stop5h 20m
Deal found 9/30![Southwest logo]()
$438
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/309:00 am -
1 stop5h 38m
Wed 2/311:20 am -
1 stop7h 10m
Deal found 9/29![United Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:49 pm -
1 stop5h 49m
Sun 10/1810:40 pm -
1 stop9h 22m
Deal found 9/29![American Airlines logo]()
$572
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:45 am -
Nonstop3h 55m
Mon 10/263:40 pm -
1 stop5h 45m
Deal found 10/2![Southwest logo]()
$440
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:33 pm -
1 stop5h 37m
Wed 2/34:10 pm -
1 stop5h 34m
Deal found 9/30![United Airlines logo]()
$464
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:25 am -
Nonstop3h 25m
Sat 11/1410:20 am -
Nonstop3h 10m
Deal found 10/2![Southwest logo]()
$449
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:30 am -
1 stop5h 35m
Tue 10/2010:11 am -
1 stop8h 23m
Deal found 10/1![United Airlines logo]()
$464
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:40 pm -
1 stop5h 40m
Mon 11/212:35 pm -
Nonstop3h 05m
Deal found 9/29![Southwest logo]()
$449
Last-minute flights from Missouri to San DiegoDiscover last-minute flight deals from Missouri to San Diego. Data last updated October 3, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to San Diego. Data last updated October 3, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:43 pm -
1 stop5h 14m
Tue 11/36:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:43 pm -
1 stop29h 14m
Tue 11/310:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$129
This Frontier deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:43 pm -
1 stop5h 14m
Sat 10/316:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$120
This Mytrip deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:26 pm -
2 stops33h 31m
Mon 11/26:25 am -
1 stop10h 49m
Deal found 9/30![Frontier logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Tue 11/310:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Mon 11/210:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$128
This Cheapflightsfares deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Tue 11/34:53 pm -
1 stop24h 54m
Deal found 9/29![Frontier logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Mon 11/210:56 am -
2 stops30h 51m
Deal found 9/29![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:43 pm -
1 stop5h 14m
Wed 11/46:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$111
This Cheapflightsfares deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:43 pm -
1 stop21h 15m
Sat 11/146:25 am -
1 stop11h 22m
Deal found 9/29![Frontier logo]()
$113
One-way flights from Missouri to San DiegoSearch for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
Search for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
This Frontier deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:59 pm -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$38
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$42
This Frontier deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:43 pm -
1 stop5h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$58
This Trip.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:43 pm -
2 stops18h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Frontier logo]()
$60
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:54 pm -
1 stop6h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Frontier logo]()
$61
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:43 pm -
2 stops15h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:58 pm -
2 stops18h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:43 pm -
1 stop29h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$65
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:59 pm -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$67
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:44 pm -
2 stops31h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$70
This Super.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:43 pm -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:29 pm -
1 stop5h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Frontier logo]()
$74
Find flight deals from Missouri to San Diego
Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated October 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $76 (Cheapflightsfares) |
One-way from | $38 (Frontier) |
Popular in | January |
Cheapest in | July |
Average price | $394 |
Good round-trip deal | $497 or less |
Good one-way deal | $229 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 3, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Wed 12/2
8:29 pm-11:57 pm
1 stop5h 28m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$140
Quickest round-trip
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Wed 10/28
7:20 am-8:50 am
Nonstop3h 30m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$149
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 10/29
7:45 am-12:25 pm
1 stop6h 40m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$181
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 12/31
6:20 am-2:33 pm
1 stop10h 13m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$181
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 10/22
5:10 am-9:20 am
1 stop6h 10m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$181
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Fri 12/25
11:50 am-3:25 pm
1 stop5h 35m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$184
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Tue 11/3
12:40 pm-5:25 pm
2 stops6h 45m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$186
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 10/29
8:30 am-10:25 am
Nonstop3h 55m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$205
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Tue 11/3
12:00 pm-7:36 pm
1 stop9h 36m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$210
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 12/10
8:25 am-10:20 am
Nonstop3h 55m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$218
Showing 1-10 of 59 resultsSorted by cheapest first
Best time to book a flight from Missouri to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
MCI-SAN
STL-SAN
SGF-SAN
COU-SAN
JLN-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to San Diego
USMO-SAN
MCI-SAN
STL-SAN
SGF-SAN
COU-SAN
What is the cheapest month to book a flight from Missouri to San Diego?
Currently, April is the cheapest month in which you can book a flight from Missouri to San Diego (average of $355). Flying from Missouri to San Diego in March is currently the most expensive (average of $428). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SAN?
Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 3, 2026.
When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 26% versus a flight in the evening.
How much does it cost to fly round-trip from Missouri to San Diego?
Airfare is below average for this route at the moment.
Missouri to San Diego flights typically cost between $343 and $508 in October.The cheapest round-trip price found within the last 5 days was $297 on Frontier (Oct 29-Nov 2).
How far ahead should I book a flight from Missouri to San Diego?
Booking 61 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to San Diego
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Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to San Diego by cabin class
Find flights from Missouri to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and San Diego flights
Browse other Missouri and San Diego flight options. Last updated on October 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 3, 2026.
Missouri to San Diego flights
Consider these flights traveling from Missouri to San Diego.
Top 7 airlines flying from Missouri to San Diego
Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$262 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$186 | Average$423 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$215 | Average$298 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$216 | Average$371 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$231 | Average$431 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$418 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$268 | Average$434 | FlexibilityNo cancel fee | On-time63% |