$81+ Cheap flights from Missouri to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Sep 19 — Sep 261
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to San Diego
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Cheapest flights from Missouri to San DiegoExplore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:17 pm -
1 stop11h 42m
Tue 11/178:32 pm -
1 stop14h 50m
Deal found 8/15![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:32 pm -
1 stop29h 19m
Sat 9/266:25 am -
1 stop11h 12m
Deal found 8/18![Frontier logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:32 pm -
1 stop29h 19m
Tue 9/156:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:43 pm -
1 stop29h 13m
Wed 10/216:25 am -
1 stop11h 23m
Deal found 8/15![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:32 pm -
1 stop21h 26m
Wed 9/236:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:32 pm -
1 stop29h 19m
Tue 9/156:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:43 pm -
1 stop29h 13m
Thu 10/226:25 am -
1 stop11h 23m
Deal found 8/19![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:32 pm -
1 stop5h 19m
Wed 9/236:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:17 pm -
1 stop27h 24m
Mon 11/98:32 pm -
1 stop14h 50m
Deal found 8/15![Frontier logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:32 pm -
1 stop21h 26m
Mon 9/144:54 pm -
1 stop24h 43m
Deal found 8/18![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:10 pm -
1 stop29h 41m
Thu 9/177:04 pm -
2 stops38h 28m
Deal found 8/17![Frontier logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:35 am -
2 stops23h 44m
Wed 11/48:32 pm -
1 stop20h 43m
Deal found 8/15![Frontier logo]()
$263
Best flights from Missouri to San DiegoDiscover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
Discover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/410:45 am -
1 stop9h 42m
Sun 2/76:15 am -
1 stop9h 46m
Deal found 8/16![Delta logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:43 pm -
1 stop21h 25m
Sun 10/258:34 pm -
2 stops21h 14m
Deal found 8/19![Frontier logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:30 am -
1 stop5h 35m
Sat 9/126:15 am -
2 stops9h 47m
Deal found 8/15![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
Nonstop4h 00m
Wed 11/46:30 am -
1 stop5h 20m
Deal found 8/15![Southwest logo]()
$358
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:17 am -
2 stops12h 53m
Tue 10/209:20 am -
1 stop12h 39m
Deal found 8/18![Alaska Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:20 am -
2 stops13h 31m
Tue 10/206:57 pm -
2 stops11h 56m
Deal found 8/19![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:15 am -
2 stops10h 53m
Mon 10/52:07 pm -
1 stop6h 48m
Deal found 8/18![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:45 pm -
1 stop8h 30m
Tue 10/2012:05 pm -
Nonstop3h 40m
Deal found 8/19![Southwest logo]()
$362
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops12h 10m
Tue 9/299:31 am -
1 stop12h 28m
Deal found 8/18![Alaska Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:30 pm -
2 stops8h 38m
Wed 10/214:11 pm -
1 stop5h 33m
Deal found 8/15![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:22 pm -
2 stops10h 29m
Sat 10/317:45 am -
2 stops11h 24m
Deal found 8/15![Delta logo]()
$383
This Alaska Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:17 am -
2 stops13h 03m
Tue 10/206:53 am -
1 stop8h 25m
Deal found 8/15![Alaska Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:00 pm -
Nonstop3h 15m
Wed 10/78:30 am -
1 stop7h 45m
Deal found 8/16![Southwest logo]()
$399
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/83:12 pm -
1 stop8h 58m
Tue 9/1511:00 am -
2 stops9h 55m
Deal found 8/18![United Airlines logo]()
$408
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:53 pm -
1 stop7h 28m
Tue 9/157:00 am -
2 stops14h 59m
Deal found 8/18![Alaska Airlines logo]()
$416
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:15 am -
Nonstop3h 30m
Sat 10/317:20 am -
1 stop7h 10m
Deal found 8/18![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
2 stops8h 18m
Wed 9/166:30 am -
1 stop7h 41m
Deal found 8/19![United Airlines logo]()
$412
This Alaska Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:30 am -
2 stops13h 06m
Sat 9/196:15 am -
2 stops15h 15m
Deal found 8/19![Alaska Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:15 am -
Nonstop3h 30m
Sun 11/112:30 pm -
1 stop4h 30m
Deal found 8/19![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:25 am -
2 stops11h 20m
Mon 9/289:20 pm -
1 stop9h 28m
Deal found 8/17![United Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3110:53 am -
2 stops11h 52m
Sun 9/610:40 pm -
1 stop9h 32m
Deal found 8/17![United Airlines logo]()
$412
This Alaska Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:17 am -
2 stops14h 12m
Sun 10/257:50 am -
2 stops14h 09m
Deal found 8/19![Alaska Airlines logo]()
$500
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:30 am -
1 stop8h 32m
Sat 9/56:20 am -
2 stops10h 26m
Deal found 8/17![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/241:40 pm -
2 stops8h 44m
Tue 12/17:41 pm -
2 stops14h 25m
Deal found 8/15![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:53 am -
2 stops11h 09m
Sat 9/197:41 pm -
2 stops12h 31m
Deal found 8/19![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:40 pm -
2 stops8h 44m
Thu 11/126:20 am -
2 stops12h 39m
Deal found 8/15![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:01 am -
1 stop7h 54m
Wed 11/411:21 am -
1 stop7h 20m
Deal found 8/17![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:20 am -
1 stop9h 10m
Sat 9/1211:00 am -
1 stop7h 39m
Deal found 8/17![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
1 stop9h 12m
Tue 11/310:40 am -
1 stop8h 57m
Deal found 8/17![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:30 am -
2 stops14h 04m
Sun 9/61:21 pm -
2 stops8h 23m
Deal found 8/18![United Airlines logo]()
$419
Last-minute flights from Missouri to San DiegoDiscover last-minute flight deals from Missouri to San Diego. Data last updated August 20, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to San Diego. Data last updated August 20, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:58 pm -
1 stop5h 53m
Sun 9/139:03 pm -
1 stop12h 14m
Deal found 8/15![Frontier logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:27 pm -
2 stops32h 24m
Mon 9/146:25 am -
1 stop10h 52m
Deal found 8/15![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:32 pm -
1 stop29h 19m
Tue 9/156:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:32 pm -
1 stop29h 19m
Tue 9/156:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:32 pm -
1 stop21h 26m
Mon 9/144:54 pm -
1 stop24h 43m
Deal found 8/18![Frontier logo]()
$217
This Frontier deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:32 pm -
1 stop5h 19m
Wed 9/166:25 am -
1 stop11h 12m
Deal found 8/15![Frontier logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:10 pm -
1 stop29h 41m
Thu 9/177:04 pm -
2 stops38h 28m
Deal found 8/17![Frontier logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:32 pm -
1 stop5h 19m
Wed 9/236:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:32 pm -
1 stop21h 26m
Wed 9/236:25 am -
1 stop11h 12m
Deal found 8/19![Frontier logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:32 pm -
1 stop21h 26m
Fri 9/254:54 pm -
1 stop24h 43m
Deal found 8/19![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:32 pm -
1 stop29h 19m
Fri 9/254:54 pm -
1 stop24h 43m
Deal found 8/19![Frontier logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:32 pm -
1 stop29h 19m
Sat 9/266:25 am -
1 stop11h 12m
Deal found 8/18![Frontier logo]()
$196
One-way flights from Missouri to San DiegoSearch for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
Search for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/218:10 pm -
1 stop29h 41m
Deal found 8/18![Frontier logo]()
$81
This Trip.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/142:17 pm -
1 stop11h 42m
Deal found 8/15![Frontier logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:00 pm -
1 stop29h 56m
Deal found 8/19![Frontier logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:17 pm -
1 stop11h 42m
Deal found 8/15![Frontier logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:32 pm -
1 stop28h 21m
Deal found 8/17![Frontier logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:19 pm -
1 stop9h 37m
Deal found 8/15![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:42 pm -
1 stop6h 14m
Deal found 8/18![Frontier logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:17 pm -
1 stop11h 42m
Deal found 8/17![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:10 pm -
1 stop29h 41m
Deal found 8/16![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:32 pm -
1 stop29h 19m
Deal found 8/18![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:10 pm -
1 stop21h 31m
Deal found 8/18![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/218:32 pm -
1 stop21h 27m
Deal found 8/19![Frontier logo]()
$99
Find flight deals from Missouri to San Diego
Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated August 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (Kiwi.com) |
One-way from | $81 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $349 |
Good round-trip deal | $385 or less |
Good one-way deal | $233 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 2/4
10:45 am-6:27 pm
1 stop9h 42m
San Diego
Sun 2/7
6:15 am-6:01 pm
1 stop9h 46m
$307
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Thu 10/22
8:43 pm-4:08 pm
1 stop21h 25m
San Diego
Sun 10/25
8:34 pm-7:48 pm
2 stops21h 14m
$308
SpringfieldSan Diego
SGF Springfield-Branson - SAN San Diego
SGFSAN
Springfield-Branson
Sun 9/6
5:30 am-9:05 am
1 stop5h 35m
San Diego
Sat 9/12
6:15 am-6:02 pm
2 stops9h 47m
$344
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Sat 10/17
11:20 am-10:51 pm
2 stops13h 31m
San Diego
Tue 10/20
6:57 pm-8:53 am
2 stops11h 56m
$353
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Mon 11/2
8:30 am-10:30 am
Nonstop4h 00m
San Diego
Wed 11/4
6:30 am-1:50 pm
1 stop5h 20m
$358
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 10/2
11:15 am-8:08 pm
2 stops10h 53m
San Diego
Mon 10/5
2:07 pm-10:55 pm
1 stop6h 48m
$359
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Sat 10/17
1:45 pm-8:15 pm
1 stop8h 30m
San Diego
Tue 10/20
12:05 pm-5:45 pm
Nonstop3h 40m
$362
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Wed 10/14
6:17 am-5:10 pm
2 stops12h 53m
San Diego
Tue 10/20
9:20 am-11:59 pm
1 stop12h 39m
$371
Kansas CitySan Diego
MCI Kansas City - SAN San Diego
MCISAN
Kansas City
Wed 9/23
7:00 am-5:10 pm
2 stops12h 10m
San Diego
Tue 9/29
9:31 am-11:59 pm
1 stop12h 28m
$371
JoplinSan Diego
JLN Joplin - SAN San Diego
JLNSAN
Joplin
Fri 10/16
1:30 pm-8:08 pm
2 stops8h 38m
San Diego
Wed 10/21
4:11 pm-11:44 pm
1 stop5h 33m
$379
Showing 1-10 of 59 resultsSorted by cheapest first
Best time to book a flight from Missouri to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
MCI-SAN
STL-SAN
SGF-SAN
COU-SAN
JLN-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to San Diego
USMO-SAN
MCI-SAN
STL-SAN
SGF-SAN
COU-SAN
What is the cheapest month to book a flight from Missouri to San Diego?
Currently, September is the cheapest month in which you can book a flight from Missouri to San Diego (average of $328). Flying from Missouri to San Diego in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SAN?
Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2026.
When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 23% versus a flight at noon.
How much does it cost to fly round-trip from Missouri to San Diego?
Airfare is below average for this route at the moment.
Missouri to San Diego flights typically cost between $282 and $506 in September.The cheapest round-trip price found within the last 5 days was $262 on Frontier (Sep 12-Sep 17).
How far ahead should I book a flight from Missouri to San Diego?
Booking 35 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest day to fly from Missouri to San Diego?
Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on August 15, 2026.
Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Related info for your journey
Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Coronado
Poway
San Ysidro
La Mesa
Santee
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to San Diego
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Complete your trip
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Search flights from Missouri to San Diego by cabin class
Find flights from Missouri to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and San Diego flights
Browse other Missouri and San Diego flight options. Last updated on August 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 20, 2026.
Missouri to San Diego flights
Consider these flights traveling from Missouri to San Diego.
Top 6 airlines flying from Missouri to San Diego
Discover the top 6 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$96 | Average$245 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$182 | Average$360 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$216 | Average$295 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$231 | Average$429 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$430 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$418 | Average$438 | FlexibilityNo cancel fee | On-time75% |