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$57+ Cheap flights from Mississippi to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SAN
Oct 8 — Oct 151
Wed 10/8
Wed 10/15
1 adult, Economy
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Cheap flight deals from Mississippi to San Diego

Keep the following information in mind while searching for Mississippi to San Diego flight deals. Data was last updated September 8, 2025.

Round-trip from

$170
(Booking.com)

One-way from

$57
(Cheapflightsfares)

Popular in

December

Cheapest in

August

Average price

$427
From Mississippi to San Diego
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One-way flight from Mississippi to San Diego
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Highest demand for flights based on searches. 7% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mississippi to San Diego

Cheapest flights from Mississippi to San Diego
Explore the most affordable flight options available from Mississippi to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2025.

This Booking.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/223:01 pmMEM - SAN
1 stop9h 25mSpirit Airlines
Fri 9/266:15 amSAN - MEM
2 stops15h 35mSpirit Airlines
Deal found 9/7$170
This Priceline deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:10 pmMEM - SAN
1 stop5h 40mFrontier
Mon 11/176:41 amSAN - MEM
1 stop10h 41mFrontier
Deal found 9/7$185
This Frontier deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:33 pmMEM - SAN
1 stop7h 20mFrontier
Mon 10/66:35 amSAN - MEM
1 stop8h 52mFrontier
Deal found 9/7$195
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/13:01 pmMEM - SAN
1 stop10h 33mMultiple Airlines
Wed 10/88:00 amSAN - MEM
1 stop28h 02mMultiple Airlines
Deal found 9/8$201
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/73:52 pmMEM - SAN
1 stop9h 56mMultiple Airlines
Sun 11/98:30 amSAN - MEM
1 stop26h 01mMultiple Airlines
Deal found 9/6$202
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/201:45 pmMEM - SAN
1 stop11h 19mMultiple Airlines
Mon 10/273:23 pmSAN - MEM
1 stop20h 39mMultiple Airlines
Deal found 9/6$204
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:57 pmMEM - SAN
1 stop8h 23mMultiple Airlines
Thu 11/133:59 pmSAN - MEM
1 stop18h 32mMultiple Airlines
Deal found 9/7$209
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2612:43 pmMEM - SAN
1 stop11h 43mMultiple Airlines
Thu 10/28:25 amSAN - MEM
1 stop25h 40mMultiple Airlines
Deal found 9/8$211
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:48 pmMEM - SAN
1 stop24h 43mMultiple Airlines
Fri 10/36:15 amSAN - MEM
2 stops15h 35mMultiple Airlines
Deal found 9/7$216
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:57 pmMEM - SAN
1 stop8h 23mMultiple Airlines
Wed 10/228:00 amSAN - MEM
1 stop28h 02mMultiple Airlines
Deal found 9/7$217
This KAYAK deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/243:01 pmMEM - SAN
1 stop10h 33mSpirit Airlines
Wed 10/16:15 amSAN - MEM
1 stop5h 42mSpirit Airlines
Deal found 9/8$222
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/173:40 pmBTR - SAN
1 stop7h 40mDelta
Fri 10/249:48 pmSAN - BTR
1 stop9h 49mDelta
Deal found 9/7$289

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 8, 2025.
Use the filters below to find and compare flights from Mississippi to San Diego that are best for you.

Fly from

Mississippi

Fly to

San Diego

Route

Depart

Return

Price

MemphisSan Diego

MEM - SAN

MEMSAN

Memphis

Thu 11/13

8:10 pm-11:50 pm

1 stop5h 40m

San Diego

Mon 11/17

6:25 am-7:22 pm

2 stops10h 57m

$228

MemphisSan Diego

MEM - SAN

MEMSAN

Memphis

Mon 10/20

1:45 pm-11:04 pm

1 stop11h 19m

San Diego

Tue 10/28

9:00 am-2:02 pm

2 stops27h 02m

$256

MemphisSan Diego

MEM - SAN

MEMSAN

Memphis

Thu 10/16

8:10 pm-11:50 pm

1 stop5h 40m

San Diego

Sun 10/19

6:41 am-7:23 pm

1 stop10h 42m

$268

MemphisSan Diego

MEM - SAN

MEMSAN

Memphis

Wed 11/12

2:42 pm-8:13 pm

1 stop7h 31m

San Diego

Wed 11/19

6:20 am-6:01 pm

1 stop9h 41m

$287

Baton RougeSan Diego

BTR - SAN

BTRSAN

Baton Rouge Ryan

Sat 11/8

12:10 pm-4:25 pm

1 stop6h 15m

San Diego

Mon 11/10

10:20 am-5:28 pm

1 stop5h 08m

$289

Baton RougeSan Diego

BTR - SAN

BTRSAN

Baton Rouge Ryan

Fri 10/17

3:40 pm-9:20 pm

1 stop7h 40m

San Diego

Fri 10/24

10:30 pm-9:37 am

1 stop9h 07m

$289

Baton RougeSan Diego

BTR - SAN

BTRSAN

Baton Rouge Ryan

Sat 10/4

2:00 pm-6:10 pm

1 stop6h 10m

San Diego

Sat 10/11

8:00 am-3:24 pm

1 stop5h 24m

$289

GulfportSan Diego

GPT - SAN

GPTSAN

Gulfport Biloxi Regional

Tue 9/30

2:00 pm-6:10 pm

1 stop6h 10m

San Diego

Sat 10/11

8:00 am-4:12 pm

1 stop6h 12m

$289

GulfportSan Diego

GPT - SAN

GPTSAN

Gulfport Biloxi Regional

Sat 11/1

1:24 pm-8:02 pm

2 stops8h 38m

San Diego

Thu 11/6

2:39 pm-11:07 pm

1 stop6h 28m

$294

GulfportSan Diego

GPT - SAN

GPTSAN

Gulfport Biloxi Regional

Sat 11/8

12:10 pm-6:24 pm

2 stops8h 14m

San Diego

Sat 11/15

7:21 am-5:40 pm

1 stop8h 19m

$294

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/7

Showing 1-10 of 50 results
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Best time to book a flight from Mississippi to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to San Diego

What is the cheapest month to book a flight from Mississippi to San Diego?

Currently, August is the cheapest month in which you can book a flight from Mississippi to San Diego (average of $286). Flying from Mississippi to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to SAN?

Find hourly flight availability from Mississippi to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 8, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to San Diego as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Mississippi?

    For a flight from Mississippi to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How long is the flight from Mississippi to San Diego?

    Frontier, Delta, and United Airlines can get you from Mississippi to San Diego in just under 5h 40m. Your travel time can differ by up to 1h 51m. Mississippi and San Diego are separated by a distance of 1563 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mississippi to San Diego one-way?

    One-way options have recently been found by users for as low as $154 on Delta. Other airlines that offer cheap prices include United Airlines from $238 and American Airlines from $294 one-way.

  • What are the most popular routes from Mississippi to San Diego?

    The most popular flight routes from Mississippi to San Diego are Memphis - San Diego, Gulfport Biloxi Regional - San Diego and Baton Rouge Ryan - San Diego.

  • Can I find deals for flights from Mississippi to San Diego that include hotel bookings?

    Yes. In addition to deals on Mississippi to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to San Diego.

  • Can I find deals for business class flights from Mississippi to San Diego?

    Yes. Cheapflights offers flight deals from Mississippi to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to San Diego (average of $286). Flying from Mississippi to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

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Alternative routes for Mississippi to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Mississippi to San Diego

Discover the top 4 airlines that operate flights from Mississippi to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 8, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$273Average$507FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$276Average$451FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$366FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$371Average$521FlexibilityNo cancel feeOn-time63%

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