$101+ Cheap flights from Knoxville to San Diego (TYS - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Mar 5 — Mar 121
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to San DiegoExplore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Priceline deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
- SAN
1 stop6h 55m
Frontier
Mon 3/96:25 am
SAN
- TYS
1 stop6h 00m
Frontier
Deal found 2/2![Frontier logo]()
$225
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SAN
1 stop10h 33m
Frontier
Sun 4/266:25 am
SAN
- TYS
1 stop6h 08m
Frontier
Deal found 2/2![Frontier logo]()
$245
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:13 pm
TYS
- SAN
1 stop28h 28m
Frontier
Thu 2/1911:59 am
SAN
- TYS
1 stop28h 28m
Frontier
Deal found 2/2![Frontier logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:21 pm
TYS
- SAN
2 stops29h 20m
Multiple Airlines
Mon 3/94:29 pm
SAN
- TYS
1 stop22h 05m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:00 pm
TYS
- SAN
1 stop8h 19m
Delta
Tue 8/182:00 pm
SAN
- TYS
1 stop6h 47m
Delta
Deal found 2/2![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
TYS
- SAN
2 stops8h 57m
United Airlines
Tue 3/171:53 pm
SAN
- TYS
1 stop6h 51m
United Airlines
Deal found 2/2![United Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:30 am
TYS
- SAN
1 stop7h 17m
Multiple Airlines
Wed 3/48:45 am
SAN
- TYS
2 stops23h 49m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:15 pm
TYS
- SAN
1 stop7h 11m
United Airlines
Mon 4/276:20 am
SAN
- TYS
1 stop7h 32m
United Airlines
Deal found 2/2![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:26 pm
TYS
- SAN
1 stop8h 40m
Delta
Mon 4/279:45 pm
SAN
- TYS
1 stop8h 39m
Delta
Deal found 2/2![Delta logo]()
$304
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:30 am
TYS
- SAN
1 stop7h 51m
United Airlines
Wed 6/106:40 am
SAN
- TYS
1 stop7h 21m
United Airlines
Deal found 2/3![United Airlines logo]()
$308
Best flights from Knoxville to San DiegoDiscover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Priceline deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
- SAN
1 stop6h 55m
Frontier
Mon 3/96:25 am
SAN
- TYS
1 stop6h 00m
Frontier
Deal found 2/2![Frontier logo]()
$225
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:05 pm
TYS
- SAN
1 stop7h 45m
United Airlines
Sat 5/3010:40 pm
SAN
- TYS
1 stop8h 24m
United Airlines
Deal found 2/2![United Airlines logo]()
$277
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:02 am
TYS
- SAN
1 stop10h 17m
Delta
Sat 4/1810:10 pm
SAN
- TYS
1 stop9h 11m
Delta
Deal found 2/1![Delta logo]()
$277
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SAN
1 stop10h 33m
Frontier
Sun 4/266:25 am
SAN
- TYS
1 stop6h 08m
Frontier
Deal found 2/2![Frontier logo]()
$245
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:13 pm
TYS
- SAN
1 stop28h 28m
Frontier
Thu 2/1911:59 am
SAN
- TYS
1 stop28h 28m
Frontier
Deal found 2/2![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:26 pm
TYS
- SAN
1 stop8h 40m
Delta
Tue 4/286:15 am
SAN
- TYS
1 stop7h 27m
Delta
Deal found 2/2![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:15 pm
TYS
- SAN
1 stop7h 11m
United Airlines
Mon 4/276:20 am
SAN
- TYS
1 stop7h 32m
United Airlines
Deal found 2/2![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:50 am
TYS
- SAN
1 stop9h 30m
Delta
Tue 4/286:15 am
SAN
- TYS
1 stop7h 27m
Delta
Deal found 2/2![Delta logo]()
$277
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:26 pm
TYS
- SAN
1 stop8h 40m
Delta
Mon 4/279:45 pm
SAN
- TYS
1 stop8h 39m
Delta
Deal found 2/2![Delta logo]()
$304
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:50 am
TYS
- SAN
1 stop9h 30m
Delta
Mon 4/209:45 pm
SAN
- TYS
1 stop8h 39m
Delta
Deal found 2/1![Delta logo]()
$304
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:54 pm
TYS
- SAN
1 stop8h 31m
Delta
Mon 4/209:45 pm
SAN
- TYS
1 stop8h 39m
Delta
Deal found 2/1![Delta logo]()
$304
Last-minute flights from Knoxville to San DiegoDiscover last-minute flight deals from Knoxville to San Diego. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Diego. Data last updated February 3, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:25 pm
TYS
- SAN
1 stop10h 43m
Frontier
Sun 2/88:16 pm
SAN
- TYS
1 stop16h 19m
Frontier
Deal found 2/2![Frontier logo]()
$341
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:13 pm
TYS
- SAN
1 stop28h 28m
Frontier
Thu 2/1911:59 am
SAN
- TYS
1 stop28h 28m
Frontier
Deal found 2/2![Frontier logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/161:40 pm
TYS
- SAN
2 stops33h 44m
Multiple Airlines
Thu 2/196:25 am
SAN
- TYS
1 stop7h 57m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:30 am
TYS
- SAN
1 stop7h 17m
Multiple Airlines
Wed 3/48:45 am
SAN
- TYS
2 stops23h 49m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$294
This Priceline deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
- SAN
1 stop6h 55m
Frontier
Mon 3/96:25 am
SAN
- TYS
1 stop6h 00m
Frontier
Deal found 2/2![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:21 pm
TYS
- SAN
2 stops29h 20m
Multiple Airlines
Mon 3/94:29 pm
SAN
- TYS
1 stop22h 05m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/58:30 am
TYS
- SAN
1 stop12h 01m
Multiple Airlines
Mon 3/94:29 pm
SAN
- TYS
1 stop22h 05m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
TYS
- SAN
1 stop10h 48m
Frontier
Sun 3/156:25 am
SAN
- TYS
1 stop30h 00m
Frontier
Deal found 2/1![Frontier logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:00 am
TYS
- SAN
1 stop8h 31m
Multiple Airlines
Sun 3/159:18 pm
SAN
- TYS
1 stop15h 07m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
TYS
- SAN
1 stop7h 38m
United Airlines
Tue 3/171:53 pm
SAN
- TYS
1 stop6h 51m
United Airlines
Deal found 2/2![United Airlines logo]()
$277
One-way flights from Knoxville to San DiegoSearch for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SAN
1 stop10h 33m
Frontier
Deal found 2/2![Frontier logo]()
$101
This Priceline deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
- SAN
1 stop6h 55m
Frontier
Deal found 2/2![Frontier logo]()
$116
This Trip.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:28 pm
TYS
- SAN
1 stop10h 33m
Frontier
Deal found 2/2![Frontier logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:54 pm
TYS
- SAN
2 stops30h 14m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$129
This WAYA deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
TYS
- SAN
1 stop10h 48m
Frontier
Deal found 2/1![Frontier logo]()
$131
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:13 am
TYS
- SAN
1 stop10h 15m
Delta
Deal found 2/3![Delta logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:36 pm
TYS
- SAN
3 stops27h 05m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:00 am
TYS
- SAN
1 stop15h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$154
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/94:30 pm
TYS
- SAN
1 stop10h 38m
Frontier
Deal found 2/3![Frontier logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:14 pm
TYS
- SAN
2 stops47h 29m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:54 pm
TYS
- SAN
2 stops30h 14m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$164
Find flight deals from Knoxville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $225 (Priceline) |
One-way from | $101 (Frontier) |
Popular in | December |
Cheapest in | July |
Average price | $313 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.
Fly from
Knoxville
Fly to
San Diego
Route
Depart
Return
Price
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Mon 3/2
8:13 pm-12:08 am
1 stop6h 55m
San Diego
Mon 3/9
6:25 am-3:25 pm
1 stop6h 00m
$225
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Thu 4/23
4:28 pm-12:01 am
1 stop10h 33m
San Diego
Sun 4/26
6:25 am-3:33 pm
1 stop6h 08m
$245
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Mon 2/16
8:13 pm-9:41 pm
1 stop28h 28m
San Diego
Thu 2/19
11:59 am-7:27 pm
1 stop28h 28m
$246
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Sat 5/23
3:05 pm-7:50 pm
1 stop7h 45m
San Diego
Sat 5/30
10:40 pm-10:04 am
1 stop8h 24m
$277
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 4/14
11:02 am-6:19 pm
1 stop10h 17m
San Diego
Sat 4/18
10:10 pm-10:21 am
1 stop9h 11m
$277
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 4/22
5:26 pm-11:06 pm
1 stop8h 40m
San Diego
Tue 4/28
6:15 am-4:42 pm
1 stop7h 27m
$277
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 4/21
7:50 am-2:20 pm
1 stop9h 30m
San Diego
Tue 4/28
6:15 am-4:42 pm
1 stop7h 27m
$277
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 4/22
5:15 pm-9:26 pm
1 stop7h 11m
San Diego
Mon 4/27
6:20 am-4:52 pm
1 stop7h 32m
$299
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 4/21
5:26 pm-11:06 pm
1 stop8h 40m
San Diego
Mon 4/27
9:45 pm-9:24 am
1 stop8h 39m
$304
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 4/15
7:50 am-2:20 pm
1 stop9h 30m
San Diego
Mon 4/20
9:45 pm-9:24 am
1 stop8h 39m
$304
Showing 1-10 of 23 results
Compare providers for flights from Knoxville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
TYS-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Diego
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How far ahead should I book a flight from Knoxville to San Diego?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on January 30, 2026.
The best time to book flights from Knoxville to San Diego is 7 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Diego?
Currently, March is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $143). Flying from Knoxville to San Diego in November is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Diego?
What’s the top layover airport for flights from Knoxville to San Diego?
Share of 1-stop round-trip flights from Knoxville to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 67% of 1-stop itineraries from Knoxville to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Diego?
Average round-trip fare for 1-stop flights from Knoxville to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $250.
What’s the fastest layover option from Knoxville to San Diego?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 56m.
Which airport typically offers the quickest layover for flights from Knoxville to San Diego?
Average layover duration for 1-stop one-way flights from Knoxville to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 54m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated February 3, 2026.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Entertainment
7.0
Crew
8.5
Comfort
7.8
Food
7.1
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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Knoxville and San Diego flights
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Top 5 airlines flying from Knoxville to San Diego
Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$82 | Average$259 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$255 | Average$431 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$258 | Average$444 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$352 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$448 | FlexibilityNo cancel fee | On-time75% |