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$144+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Diego are usually found in July or January, booked 67 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Find flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:52 pmTYS - SAN
1 stop10h 07mMultiple Airlines
Sun 12/74:33 pmSAN - TYS
1 stop23h 41mMultiple Airlines
Deal found 10/23$179
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:02 pmTYS - SAN
1 stop9h 03mAmerican Airlines
Sun 12/71:44 pmSAN - TYS
1 stop7h 13mAmerican Airlines
Deal found 10/23$253
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:26 pmTYS - SAN
1 stop10h 34mMultiple Airlines
Sun 1/46:25 amSAN - TYS
2 stops31h 30mMultiple Airlines
Deal found 10/21$275
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:00 amTYS - SAN
1 stop7h 38mMultiple Airlines
Sun 12/72:02 pmSAN - TYS
2 stops22h 55mMultiple Airlines
Deal found 10/23$306
This Frontier deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:17 pmTYS - SAN
1 stop6h 33mFrontier
Mon 10/276:41 amSAN - TYS
1 stop9h 51mFrontier
Deal found 10/21$312
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:00 amTYS - SAN
1 stop19h 50mMultiple Airlines
Mon 11/171:20 pmSAN - TYS
2 stops44h 37mMultiple Airlines
Deal found 10/23$338
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:55 pmTYS - SAN
1 stop6h 59mUnited Airlines
Sat 11/158:00 amSAN - TYS
1 stop7h 04mUnited Airlines
Deal found 10/21$381
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:26 pmTYS - SAN
1 stop29h 49mFrontier
Sun 12/284:47 pmSAN - TYS
1 stop20h 04mFrontier
Deal found 10/23$383

Cheap flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$179
(Kiwi.com)

One-way from

$144
(Delta)

Popular in

April

Cheapest in

July

Average price

$458
Provider with most accurate pricing for Knoxville McGhee Tyson-San Diego flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Diego flights.
Search Deals
From Knoxville McGhee Tyson to San Diego
Search Deals
One-way flight from Knoxville McGhee Tyson to San Diego
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-11:59 pm

1 stop10h 07m

San Diego

Sun 12/7

4:33 pm-7:14 pm

1 stop23h 41m

$179

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/8

12:14 pm-4:54 pm

1 stop7h 40m

San Diego

Wed 1/14

7:10 am-5:38 pm

1 stop7h 28m

$201

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-11:59 pm

1 stop10h 07m

San Diego

Sun 12/7

2:02 pm-3:57 pm

2 stops22h 55m

$218

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 12/5

8:00 am-12:38 pm

1 stop7h 38m

San Diego

Sun 12/7

2:02 pm-3:57 pm

2 stops22h 55m

$306

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 11/13

7:00 am-11:50 pm

1 stop19h 50m

San Diego

Mon 11/17

1:20 pm-12:57 pm

2 stops44h 37m

$338

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 12/21

4:26 pm-7:15 pm

1 stop29h 49m

San Diego

Sun 12/28

4:47 pm-3:51 pm

1 stop20h 04m

$383

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 11/12

1:52 pm-7:52 pm

2 stops9h 00m

San Diego

Sat 11/15

8:00 am-6:04 pm

1 stop7h 04m

$386

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 10/29

7:45 am-2:32 pm

1 stop9h 47m

San Diego

Tue 11/4

2:05 pm-11:22 pm

1 stop6h 17m

$391

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 11/7

12:50 pm-5:55 pm

1 stop8h 05m

San Diego

Tue 11/11

8:00 am-1:44 pm

2 stops50h 44m

$391

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 11/6

2:34 pm-7:47 am

1 stop20h 13m

San Diego

Mon 11/10

6:25 am-10:34 am

2 stops25h 09m

$405

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/21

Showing 1-10 of 20 results
1
2

Compare providers for flights from Knoxville to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on October 17, 2025.

The best time to book flights from Knoxville to San Diego is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, March is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $114). Flying from Knoxville to San Diego in June is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAN?

Find hourly flight availability from Knoxville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to San Diego in the evening. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Knoxville to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Diego flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 23, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,155 reviews
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
7,981 reviews
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,991 reviews
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,028 reviews
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,128 reviews
Alaska Airlines
8.0
Very good
11,155 reviews

Comfort

7.8

Entertainment

7.0

Food

7.1

Crew

8.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Diego?

    American Airlines and Frontier can get you from Knoxville to San Diego in just under 7h 40m. Your travel time can differ by up to 2h 27m. The distance between Knoxville and San Diego is about 1897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    Frontier, at $150, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Frontier is priced at 62% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $114). Flying from Knoxville to San Diego in June is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Imperial Beach
National City

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Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$150Average$219FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$258Average$415FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$439FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$371FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$503FlexibilityNo cancel feeOn-time75%

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