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$131+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Diego are usually found in July or January, booked 67 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$210
(Frontier)

One-way from

$131
(Kiwi.com)

Popular in

April

Cheapest in

July

Average price

$366
From Knoxville McGhee Tyson to San Diego
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One-way flight from Knoxville McGhee Tyson to San Diego
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Highest demand for flights based on searches. 13% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:17 pmTYS - SAN
1 stop6h 33mFrontier
Mon 10/276:41 amSAN - TYS
1 stop9h 51mFrontier
Deal found 9/16$210
This Priceline deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:17 pmTYS - SAN
1 stop6h 33mFrontier
Mon 10/276:41 amSAN - TYS
1 stop9h 51mFrontier
Deal found 9/17$216
This Priceline deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - SAN
1 stop6h 33mFrontier
Mon 10/206:41 amSAN - TYS
1 stop9h 51mFrontier
Deal found 9/17$271
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/214:40 pmTYS - SAN
1 stop6h 45mUnited Airlines
Sat 10/2510:46 amSAN - TYS
1 stop9h 04mUnited Airlines
Deal found 9/17$277
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/267:00 amTYS - SAN
1 stop29h 57mMultiple Airlines
Thu 10/3010:14 amSAN - TYS
2 stops32h 16mMultiple Airlines
Deal found 9/16$294
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:26 pmTYS - SAN
2 stops42h 00mMultiple Airlines
Sat 10/252:24 pmSAN - TYS
1 stop20h 09mMultiple Airlines
Deal found 9/16$301
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/228:35 pmTYS - SAN
1 stop28h 49mFrontier
Fri 9/267:11 pmSAN - TYS
2 stops42h 07mFrontier
Deal found 9/16$307
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:55 pmTYS - SAN
1 stop6h 59mUnited Airlines
Wed 11/1911:20 amSAN - TYS
2 stops9h 39mUnited Airlines
Deal found 9/16$310

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 11/5

5:10 am-9:56 am

1 stop7h 46m

San Diego

Wed 11/19

6:19 am-5:46 pm

1 stop8h 27m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 10/21

10:51 am-5:17 pm

2 stops9h 26m

San Diego

Sat 10/25

10:15 am-7:52 pm

1 stop6h 37m

$302

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 11/5

4:55 pm-8:54 pm

1 stop6h 59m

San Diego

Wed 11/19

11:20 am-11:59 pm

2 stops9h 39m

$310

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 10/25

4:32 pm-6:28 pm

2 stops28h 56m

San Diego

Sun 11/2

1:20 pm-6:12 pm

1 stop25h 52m

$331

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 10/14

7:00 am-11:40 am

1 stop7h 40m

San Diego

Tue 10/21

11:08 am-10:28 pm

2 stops8h 20m

$334

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 10/15

4:26 pm-7:26 am

2 stops42h 00m

San Diego

Wed 10/22

6:41 am-1:33 pm

1 stop27h 52m

$353

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:40 am

1 stop7h 40m

San Diego

Sun 11/2

10:30 pm-10:05 am

1 stop8h 35m

$354

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 12/10

12:02 pm-6:05 pm

1 stop9h 03m

San Diego

Wed 12/17

7:21 am-5:27 pm

1 stop7h 06m

$367

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 12/9

6:05 am-11:52 am

1 stop8h 47m

San Diego

Wed 12/17

6:15 am-5:12 pm

1 stop7h 57m

$367

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 10/22

8:50 am-3:50 pm

1 stop10h 00m

San Diego

Tue 10/28

5:55 pm-10:05 am

2 stops13h 10m

$372

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 20 results
1
2

Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on September 12, 2025.

The best time to book flights from Knoxville to San Diego is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAN?

Find hourly flight availability from Knoxville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to San Diego in the evening. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Knoxville to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Diego flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
8.0
Very good
7,961 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,926 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,173 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Boarding

8.1

Crew

8.5

Comfort

7.8

Food

7.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Diego?

    American Airlines and United Airlines can get you from Knoxville to San Diego in just under 7h 46m. Your travel time can differ by up to 1h 40m. The distance between Knoxville and San Diego is about 1897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    Frontier, at $150, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include United Airlines and American Airlines. Frontier is priced at 61% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City

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Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$150Average$203FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$255Average$431FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$421FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$373FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$503FlexibilityNo cancel feeOn-time75%

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