San Diego

$117+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Feb 20 — Feb 271
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Cheap flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Mytrip deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
-
SAN
1 stop6h 55m
Frontier
Thu 2/2611:59 am
SAN
-
TYS
1 stop27h 07m
Frontier
Deal found 1/21$189
This Trip.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:25 pm
TYS
-
SAN
1 stop10h 43m
Frontier
Mon 2/96:30 am
SAN
-
TYS
1 stop6h 05m
Frontier
Deal found 1/20$199
This Frontier deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/24:30 pm
TYS
-
SAN
1 stop10h 38m
Frontier
Fri 2/66:30 am
SAN
-
TYS
1 stop6h 00m
Frontier
Deal found 1/19$215
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:56 pm
TYS
-
SAN
2 stops33h 12m
Multiple Airlines
Thu 2/2611:59 am
SAN
-
TYS
1 stop27h 07m
Multiple Airlines
Deal found 1/21$270
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:25 pm
TYS
-
SAN
1 stop10h 43m
Multiple Airlines
Mon 2/99:46 am
SAN
-
TYS
2 stops45h 22m
Multiple Airlines
Deal found 1/21$272
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:45 am
TYS
-
SAN
1 stop9h 23m
American Airlines
Tue 2/246:20 am
SAN
-
TYS
1 stop7h 11m
American Airlines
Deal found 1/20$277
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
-
SAN
2 stops27h 11m
Multiple Airlines
Thu 2/266:25 am
SAN
-
TYS
1 stop7h 52m
Multiple Airlines
Deal found 1/21$308
This Priceline deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/274:20 pm
TYS
-
SAN
1 stop10h 49m
Frontier
Mon 3/306:25 am
SAN
-
TYS
1 stop6h 00m
Frontier
Deal found 1/21$310
This Expedia deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
-
SAN
1 stop6h 55m
Multiple Airlines
Sat 3/76:20 am
SAN
-
TYS
1 stop6h 17m
Multiple Airlines
Deal found 1/20$315
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:31 pm
TYS
-
SAN
1 stop9h 28m
American Airlines
Sat 5/3010:45 pm
SAN
-
TYS
1 stop9h 11m
American Airlines
Deal found 1/20$318

Find flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$189
(Mytrip)

One-way from

$117
(Frontier)

Popular in

December

Cheapest in

July

Average price

$444
Provider with most accurate pricing for Knoxville McGhee Tyson-San Diego flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Diego flights.
From Knoxville McGhee Tyson to San Diego
One-way flight from Knoxville McGhee Tyson to San Diego
Highest demand for flights based on searches. 11% potential increase in price ($51 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Average for round-trip flights in January 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 2/22

5:56 pm-12:08 am

2 stops33h 12m

San Diego

Thu 2/26

11:59 am-6:06 pm

1 stop27h 07m

$270

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 3/9

5:10 pm-11:09 pm

1 stop8h 59m

San Diego

Mon 3/16

10:10 pm-10:31 am

1 stop9h 21m

$331

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 2/14

4:29 pm-10:30 pm

1 stop9h 01m

San Diego

Thu 2/19

6:20 am-4:31 pm

1 stop7h 11m

$331

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 2/14

4:55 pm-10:00 pm

1 stop8h 05m

San Diego

Thu 2/19

11:05 am-10:30 pm

2 stops8h 25m

$336

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 3/7

6:21 pm-10:30 pm

1 stop7h 09m

San Diego

Wed 3/11

6:15 am-3:32 pm

1 stop6h 17m

$349

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 4/15

4:35 pm-11:10 pm

1 stop9h 35m

San Diego

Sun 4/19

10:10 pm-10:06 am

1 stop8h 56m

$354

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 2/22

5:47 pm-10:59 pm

1 stop8h 12m

San Diego

Sat 2/28

10:35 pm-10:45 am

1 stop9h 10m

$354

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 2/18

6:45 am-5:29 pm

2 stops13h 44m

San Diego

Wed 2/25

6:55 pm-10:49 am

2 stops12h 54m

$378

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 2/2

4:30 pm-12:08 am

1 stop10h 38m

San Diego

Wed 2/4

7:00 am-6:44 pm

2 stops32h 44m

$380

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 3/13

5:24 pm-10:59 pm

1 stop8h 35m

San Diego

Mon 3/16

10:10 pm-10:31 am

1 stop9h 21m

$381

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 19 results
1
2

Compare providers for flights from Knoxville to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on January 16, 2026.

The best time to book flights from Knoxville to San Diego is 7 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, March is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $114). Flying from Knoxville to San Diego in November is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated January 21, 2026.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Crew

8.5

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Knoxville to San Diego?

    Delta, American Airlines, and United Airlines can get you from Knoxville to San Diego in just under 8h 05m. Your travel time can differ by up to 56m. The distance between Knoxville and San Diego is about 1897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    Frontier, at $82, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Frontier is priced at 80% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Diego one-way?

    One-way options have recently been found by users for as low as $110 on Frontier. Other airlines that offer cheap prices include United Airlines from $114 and American Airlines from $138 one-way.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $114). Flying from Knoxville to San Diego in November is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for Knoxville to San Diego

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$82Average$259FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$258Average$431FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$449FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$355FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$449FlexibilityNo cancel feeOn-time75%

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