$142+ Cheap flights from Knoxville to San Diego (TYS - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Sep 30 — Oct 71
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to San DiegoExplore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 31, 2026.
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 31, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:00 am -
1 stop19h 51m
Thu 10/19:03 pm -
1 stop21h 11m
Deal found 8/27![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:03 pm -
1 stop21h 46m
Wed 10/214:53 pm -
1 stop17h 18m
Deal found 8/30![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am -
1 stop20h 26m
Wed 10/214:53 pm -
1 stop17h 18m
Deal found 8/30![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop20h 27m
Sun 11/156:25 am -
2 stops28h 06m
Deal found 8/31![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:51 pm -
2 stops35h 00m
Sat 9/266:25 am -
1 stop28h 19m
Deal found 8/27![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:54 pm -
1 stop22h 05m
Sat 10/105:44 pm -
2 stops20h 37m
Deal found 8/28![Multiple Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:01 pm -
1 stop6h 59m
Wed 12/168:00 am -
1 stop6h 30m
Deal found 8/28![Delta logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am -
1 stop20h 26m
Tue 10/206:25 am -
2 stops30h 14m
Deal found 8/30![Multiple Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:45 am -
2 stops9h 32m
Tue 11/109:40 pm -
1 stop10h 04m
Deal found 8/27![United Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am -
1 stop20h 26m
Mon 10/192:01 pm -
2 stops25h 51m
Deal found 8/30![Multiple Airlines logo]()
$369
Best flights from Knoxville to San DiegoDiscover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 31, 2026.
Discover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 31, 2026.
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:45 am -
1 stop9h 50m
Sat 9/2610:30 pm -
1 stop7h 59m
Deal found 8/27![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:50 am -
2 stops8h 15m
Sat 9/265:10 pm -
2 stops14h 45m
Deal found 8/27![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:45 am -
1 stop7h 42m
Wed 11/186:45 am -
2 stops11h 09m
Deal found 8/27![United Airlines logo]()
$468
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:40 am -
1 stop7h 02m
Mon 10/1910:00 pm -
1 stop9h 20m
Deal found 8/31![Delta logo]()
$445
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:10 am -
1 stop8h 10m
Fri 11/277:15 am -
2 stops8h 30m
Deal found 8/31![Southwest logo]()
$461
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:00 am -
2 stops13h 55m
Sat 9/196:35 am -
2 stops13h 14m
Deal found 8/27![United Airlines logo]()
$497
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:39 am -
1 stop8h 26m
Fri 10/910:00 pm -
1 stop9h 39m
Deal found 8/29![Delta logo]()
$456
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:53 pm -
2 stops9h 41m
Tue 9/156:30 am -
1 stop6h 24m
Deal found 8/29![United Airlines logo]()
$497
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:45 am -
1 stop9h 10m
Tue 10/206:57 pm -
2 stops11h 37m
Deal found 8/31![Delta logo]()
$489
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:42 am -
2 stops13h 03m
Fri 10/307:41 pm -
2 stops11h 26m
Deal found 8/27![United Airlines logo]()
$498
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop7h 02m
Fri 10/306:57 pm -
2 stops12h 42m
Deal found 8/29![Delta logo]()
$513
Last-minute flights from Knoxville to San DiegoDiscover last-minute flight deals from Knoxville to San Diego. Data last updated August 31, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Diego. Data last updated August 31, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:46 pm -
1 stop9h 08m
Sat 9/1911:15 am -
1 stop9h 07m
Deal found 8/30![American Airlines logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:49 pm -
1 stop28h 10m
Sun 9/276:25 am -
2 stops12h 30m
Deal found 8/31![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:51 pm -
2 stops35h 00m
Sat 9/266:25 am -
1 stop28h 19m
Deal found 8/27![Multiple Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:45 am -
1 stop9h 50m
Sat 9/2610:30 pm -
1 stop7h 59m
Deal found 8/27![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:50 am -
2 stops8h 15m
Sat 9/265:10 pm -
2 stops14h 45m
Deal found 8/27![Southwest logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:30 am -
1 stop16h 47m
Thu 9/246:25 am -
2 stops12h 31m
Deal found 8/28![Multiple Airlines logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:00 am -
1 stop19h 51m
Thu 10/19:03 pm -
1 stop21h 11m
Deal found 8/27![Multiple Airlines logo]()
$272
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:40 am -
1 stop8h 45m
Mon 10/510:30 pm -
1 stop8h 04m
Deal found 8/28![Delta logo]()
$445
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:35 pm -
1 stop7h 13m
Sun 10/49:25 pm -
1 stop8h 07m
Deal found 8/30![American Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:00 pm -
2 stops9h 05m
Sun 10/46:30 am -
1 stop9h 35m
Deal found 8/30![Southwest logo]()
$444
One-way flights from Knoxville to San DiegoSearch for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated August 31, 2026.
Search for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated August 31, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am -
1 stop12h 38m
Deal found 8/27![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:30 am -
1 stop20h 26m
Deal found 8/27![Multiple Airlines logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am -
1 stop12h 38m
Deal found 8/27![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:42 pm -
2 stops39h 29m
Deal found 8/27![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:54 pm -
1 stop22h 05m
Deal found 8/30![Multiple Airlines logo]()
$161
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:15 pm -
1 stop8h 55m
Deal found 8/27![Southwest logo]()
$182
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
2 stops8h 15m
Deal found 8/31![Southwest logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
3 stops54h 37m
Deal found 8/31![Multiple Airlines logo]()
$200
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:40 pm -
1 stop8h 45m
Deal found 8/28![United Airlines logo]()
$206
Find flight deals from Knoxville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 31, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $272 (Kiwi.com) |
One-way from | $142 (Kiwi.com) |
Popular in | July |
Cheapest in | February |
Average price | $391 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 31, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 9/19
11:45 am-6:35 pm
1 stop9h 50m
San Diego
Sat 9/26
10:30 pm-9:29 am
1 stop7h 59m
$363
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 9/19
6:50 am-12:05 pm
2 stops8h 15m
San Diego
Sat 9/26
5:10 pm-10:55 am
2 stops14h 45m
$379
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 10/15
5:40 am-9:42 am
1 stop7h 02m
San Diego
Mon 10/19
10:00 pm-10:20 am
1 stop9h 20m
$445
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 10/3
11:39 am-5:05 pm
1 stop8h 26m
San Diego
Fri 10/9
10:00 pm-10:39 am
1 stop9h 39m
$456
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Fri 11/20
8:10 am-1:20 pm
1 stop8h 10m
San Diego
Fri 11/27
7:15 am-6:45 pm
2 stops8h 30m
$461
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Wed 11/11
6:45 am-11:27 am
1 stop7h 42m
San Diego
Wed 11/18
6:45 am-8:54 pm
2 stops11h 09m
$468
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Tue 10/6
11:45 am-5:55 pm
1 stop9h 10m
San Diego
Tue 10/20
6:57 pm-9:34 am
2 stops11h 37m
$489
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sun 9/6
9:00 am-7:55 pm
2 stops13h 55m
San Diego
Sat 9/19
6:35 am-10:49 pm
2 stops13h 14m
$497
Quickest round-trip
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Wed 9/9
1:53 pm-8:34 pm
2 stops9h 41m
San Diego
Tue 9/15
6:30 am-3:54 pm
1 stop6h 24m
$497
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 10/24
10:42 am-8:45 pm
2 stops13h 03m
San Diego
Fri 10/30
7:41 pm-10:07 am
2 stops11h 26m
$498
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
TYS-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Diego
Prices
More
How far ahead should I book a flight from Knoxville to San Diego?
The best time to book flights from Knoxville to San Diego is 29 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Diego?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $303). Flying from Knoxville to San Diego in July is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Diego?
Airfare is below average for this route at the moment.
Knoxville to San Diego flights typically cost between $362 and $519 in September.The cheapest round-trip price found within the last 5 days was $272 on Multiple Airlines (Sep 24-Oct 1).
What’s the top layover airport for flights from Knoxville to San Diego?
Share of 1-stop round-trip flights from Knoxville to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 75% of 1-stop itineraries from Knoxville to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Diego?
Average round-trip fare for 1-stop flights from Knoxville to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $250.
What’s the fastest layover option from Knoxville to San Diego?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 56m.
Which airport typically offers the quickest layover for flights from Knoxville to San Diego?
Average layover duration for 1-stop one-way flights from Knoxville to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 54m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 31, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Coronado
Poway
San Ysidro
La Mesa
Santee
Julian
Lemon Grove
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Knoxville and San Diego flights
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Top 6 airlines flying from Knoxville to San Diego
Discover the top 6 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 31, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$145 | Average$250 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$218 | Average$436 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$250 | Average$413 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$430 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$277 | Average$493 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$354 | Average$406 | FlexibilityNo cancel fee | On-time63% |