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$126+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Diego are usually found in January or July, booked 67 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$154
(Priceline)

One-way from

$126
(Frontier)

Popular in

April

Cheapest in

January

Average price

$416
From Knoxville McGhee Tyson to San Diego
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One-way flight from Knoxville McGhee Tyson to San Diego
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Highest demand for flights based on searches. 14% potential increase in price ($69 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Priceline deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/48:40 pmTYS - SAN
1 stop6h 13mFrontier
dom. 9/76:35 amSAN - TYS
1 stop6h 43mFrontier
Deal found 8/14$154
This Priceline deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/188:40 pmTYS - SAN
1 stop6h 13mFrontier
dom. 9/216:35 amSAN - TYS
1 stop6h 43mFrontier
Deal found 8/14$201
This FlightHub deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/65:14 pmTYS - SAN
1 stop9h 36mFrontier
sáb. 11/154:16 pmSAN - TYS
1 stop20h 58mFrontier
Deal found 8/13$245
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/77:00 amTYS - SAN
1 stop7h 09mMultiple Airlines
sáb. 9/137:15 amSAN - TYS
1 stop27h 28mMultiple Airlines
Deal found 8/12$246
This Booking.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/75:08 pmTYS - SAN
1 stop21h 01mFrontier
sáb. 9/1310:16 amSAN - TYS
2 stops27h 02mFrontier
Deal found 8/14$250
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/168:17 pmTYS - SAN
1 stop6h 33mFrontier
lun. 10/206:41 amSAN - TYS
1 stop9h 51mFrontier
Deal found 8/12$274
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/242:07 pmTYS - SAN
1 stop6h 56mAmerican Airlines
mié. 10/112:38 pmSAN - TYS
1 stop8h 43mAmerican Airlines
Deal found 8/14$277
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/264:37 pmTYS - SAN
1 stop6h 43mAmerican Airlines
sáb. 10/49:19 pmSAN - TYS
1 stop8h 18mAmerican Airlines
Deal found 8/12$283
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/712:08 pmTYS - SAN
1 stop8h 57mAmerican Airlines
lun. 11/1012:25 pmSAN - TYS
1 stop8h 20mAmerican Airlines
Deal found 8/14$289
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/2711:54 amTYS - SAN
1 stop8h 59mDelta
dom. 8/316:15 amSAN - TYS
1 stop9h 07mDelta
Deal found 8/12$308

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 9/4

8:40 pm-11:53 pm

1 stop6h 13m

San Diego

dom. 9/7

6:35 am-4:18 pm

1 stop6h 43m

$154

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 9/18

8:40 pm-11:53 pm

1 stop6h 13m

San Diego

dom. 9/21

6:35 am-4:18 pm

1 stop6h 43m

$201

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 11/6

5:14 pm-11:50 pm

1 stop9h 36m

San Diego

sáb. 11/15

4:16 pm-4:14 pm

1 stop20h 58m

$245

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

dom. 9/7

7:00 am-11:09 am

1 stop7h 09m

San Diego

sáb. 9/13

7:15 am-1:43 pm

1 stop27h 28m

$246

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

dom. 9/7

5:08 pm-11:09 am

1 stop21h 01m

San Diego

sáb. 9/13

10:16 am-4:18 pm

2 stops27h 02m

$250

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 10/16

8:17 pm-11:50 pm

1 stop6h 33m

San Diego

lun. 10/20

6:41 am-7:32 pm

1 stop9h 51m

$274

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

mié. 9/24

2:07 pm-6:03 pm

1 stop6h 56m

San Diego

mié. 10/1

12:38 pm-12:21 am

1 stop8h 43m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 9/4

8:40 pm-11:53 pm

1 stop6h 13m

$126

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

dom. 9/7

7:35 pm-10:26 pm

2 stops29h 51m

$133

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

jue. 10/16

6:30 am-11:24 pm

1 stop19h 54m

$133

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 16 results
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Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on August 8, 2025.

The best time to book flights from Knoxville to San Diego is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAN?

Find hourly flight availability from Knoxville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to San Diego in the evening. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Knoxville to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Diego flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated agosto 14, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)
Delta
8.0
Very good
7,980 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)
United Airlines
7.4
Good
8,916 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)
Frontier
5.8
Fair
3,217 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Food

7.1

Overall

8.0

Entertainment

7.0

Comfort

7.8

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOI - LAX

flying in first class, my husband froze the entire flight and was miserable. first class does not offer blankets or any entertainment. (TV etc)

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    Frontier, at $139, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Frontier is priced at 65% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
National City
Lemon Grove
Imperial Beach
Alpine

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Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$139Average$270FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$258Average$444FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$430FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$373FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$503FlexibilityNo cancel feeOn-time75%

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