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San Diego

$66+ Cheap flights from Iowa to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Iowa to San Diego

Cheapest flights from Iowa to San Diego
Explore the most affordable flight options available from Iowa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
-
SAN
2 stops30h 20m
Frontier
Thu 3/56:25 am
SAN
-
DSM
1 stop10h 17m
Frontier
Deal found 2/9$192
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:30 am
DSM
-
SAN
1 stop10h 01m
Multiple Airlines
Wed 3/258:25 am
SAN
-
DSM
1 stop8h 51m
Multiple Airlines
Deal found 2/11$203
This Priceline deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:59 pm
DSM
-
SAN
1 stop6h 09m
Frontier
Thu 3/56:25 am
SAN
-
DSM
1 stop10h 17m
Frontier
Deal found 2/9$204
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:17 pm
DSM
-
SAN
1 stop28h 24m
Frontier
Thu 2/266:25 am
SAN
-
DSM
1 stop10h 17m
Frontier
Deal found 2/8$211
This Priceline deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:07 pm
CID
-
SAN
1 stop6h 01m
Frontier
Sun 3/16:25 am
SAN
-
CID
1 stop10h 16m
Frontier
Deal found 2/9$211
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:32 pm
DSM
-
SAN
1 stop23h 41m
Multiple Airlines
Wed 3/258:25 am
SAN
-
DSM
1 stop8h 51m
Multiple Airlines
Deal found 2/11$213
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:20 pm
OMA
-
SAN
1 stop6h 10m
American Airlines
Wed 2/2511:56 am
SAN
-
OMA
1 stop8h 34m
American Airlines
Deal found 2/10$217
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
-
SAN
1 stop26h 12m
Frontier
Mon 4/66:25 am
SAN
-
DSM
1 stop10h 49m
Frontier
Deal found 2/10$220
This eDestinos deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
-
SAN
1 stop26h 12m
Multiple Airlines
Tue 3/102:08 pm
SAN
-
DSM
1 stop23h 54m
Multiple Airlines
Deal found 2/10$221
This CheapOair deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:20 pm
DSM
-
SAN
1 stop11h 41m
Frontier
Thu 4/2312:36 pm
SAN
-
DSM
1 stop22h 53m
Frontier
Deal found 2/8$222
This CheapOair deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:07 pm
CID
-
SAN
1 stop6h 01m
Frontier
Sat 2/2812:23 pm
SAN
-
CID
1 stop28h 18m
Frontier
Deal found 2/10$222
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
OMA
-
SAN
1 stop5h 15m
United Airlines
Sun 5/106:20 am
SAN
-
OMA
2 stops8h 00m
United Airlines
Deal found 2/11$222

Find flight deals from Iowa to San Diego

Keep the following information in mind while searching for Iowa to San Diego flight deals. Data was last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$169
(Kiwi.com)

One-way from

$66
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$382
Provider with most accurate pricing for Des Moines-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-San Diego flights.
Search Deals
From Iowa to San Diego
Search Deals
One-way flight from Iowa to San Diego
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($76 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Iowa to San Diego that are best for you.

Fly from

Iowa

Fly to

San Diego

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 3/1

7:27 pm-11:47 pm

2 stops30h 20m

San Diego

Thu 3/5

6:25 am-6:42 pm

1 stop10h 17m

$192

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 2/25

1:50 pm-5:40 pm

1 stop5h 50m

San Diego

Sat 2/28

6:30 am-4:19 pm

1 stop7h 49m

$217

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Sat 4/4

5:40 am-9:30 am

1 stop5h 50m

San Diego

Wed 4/8

7:55 am-3:40 pm

1 stop5h 45m

$217

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 5/27

1:50 pm-5:14 pm

1 stop5h 24m

San Diego

Thu 6/4

10:40 pm-10:27 am

1 stop9h 47m

$217

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Sat 5/23

6:00 am-9:05 am

1 stop5h 05m

San Diego

Tue 5/26

6:35 am-4:21 pm

1 stop7h 46m

$217

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 8/4

5:23 pm-8:46 pm

1 stop5h 23m

San Diego

Tue 8/11

6:30 am-4:09 pm

2 stops7h 39m

$222

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 2/24

9:00 am-5:29 pm

2 stops10h 29m

San Diego

Wed 2/25

4:10 pm-11:04 pm

1 stop4h 54m

$222

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 3/10

5:50 pm-11:48 pm

1 stop7h 58m

San Diego

Wed 3/18

6:15 am-4:51 pm

1 stop8h 36m

$227

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 3/10

5:37 am-12:58 pm

1 stop9h 21m

San Diego

Mon 3/23

10:30 pm-10:27 am

1 stop9h 57m

$227

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 3/10

5:37 am-12:58 pm

1 stop9h 21m

San Diego

Tue 3/17

10:30 pm-10:27 am

1 stop9h 57m

$227

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Diego

What is the cheapest month to book a flight from Iowa to San Diego?

Currently, August is the cheapest month in which you can book a flight from Iowa to San Diego (average of $100). Flying from Iowa to San Diego in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Iowa?

    San Diego (SAN) is the airport you will fly into if you book a flight from Iowa to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How popular is this Iowa to San Diego flight route?

    Within the past month, 1 users have taken a look at flights from Iowa to San Diego.

  • How long is the flight from Iowa to San Diego?

    A quick flight from Iowa to San Diego can take about 5h 50m. Frontier provides one of the quickest options available for as low as $217. The distance from Iowa to San Diego is about 1310 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to San Diego one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $60. However, be on the lookout for offers from Frontier and United Airlines, as they are both options that can get you from Iowa to San Diego for a low price.

  • What are the most popular routes from Iowa to San Diego?

    The most popular route from Iowa to San Diego is Des Moines - San Diego. You may also consider Omaha Eppley Airfield - San Diego or Cedar Rapids - San Diego.

  • Can I find deals for flights from Iowa to San Diego that include hotel bookings?

    Yes. In addition to deals on Iowa to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Diego.

  • Can I find deals for business class flights from Iowa to San Diego?

    Yes. Cheapflights offers flight deals from Iowa to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Iowa to San Diego (average of $100). Flying from Iowa to San Diego in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Iowa to San Diego

Discover the top 6 airlines that operate flights from Iowa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$100Average$263FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$101Average$169FlexibilityNo cancel feeOn-time88%
DeltaCheapest$118Average$340FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$385FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$253Average$408FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$303Average$467FlexibilityNo cancel feeOn-time63%

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