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$52+ Cheap flights from Iowa to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Iowa to San Diego

Cheapest flights from Iowa to San Diego
Explore the most affordable flight options available from Iowa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:25 amCID - SAN
1 stop7h 05mDelta
Wed 1/143:00 pmSAN - CID
1 stop5h 45mDelta
Deal found 12/26$439
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:53 pmOMA - SAN
1 stop5h 47mAmerican Airlines
Mon 12/296:15 amSAN - OMA
1 stop5h 39mAmerican Airlines
Deal found 12/26$451
This Frontier deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:35 pmDSM - SAN
1 stop11h 24mFrontier
Sat 1/36:25 amSAN - DSM
1 stop11h 19mFrontier
Deal found 12/26$482
This Frontier deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:29 pmDSM - SAN
1 stop5h 30mFrontier
Sat 1/36:25 amSAN - DSM
1 stop11h 19mFrontier
Deal found 12/26$502
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:35 amOMA - SAN
1 stop5h 13mAmerican Airlines
Mon 1/56:15 amSAN - OMA
1 stop5h 39mAmerican Airlines
Deal found 12/26$505
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:21 pmCID - SAN
2 stops9h 38mDelta
Tue 3/33:10 pmSAN - CID
1 stop5h 33mDelta
Deal found 12/26$523
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:15 pmOMA - SAN
1 stop5h 32mUnited Airlines
Mon 1/511:50 amSAN - OMA
2 stops9h 40mUnited Airlines
Deal found 12/26$536
This Southwest deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:30 pmOMA - SAN
1 stop5h 55mSouthwest
Thu 1/111:30 amSAN - OMA
2 stops7h 40mSouthwest
Deal found 12/26$584
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:30 pmCID - SAN
1 stop8h 45mAmerican Airlines
Tue 3/312:05 pmSAN - CID
1 stop9h 04mAmerican Airlines
Deal found 12/26$605
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:57 pmOMA - SAN
1 stop7h 19mUnited Airlines
Sat 1/34:10 pmSAN - OMA
1 stop5h 12mUnited Airlines
Deal found 12/26$715
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:46 amDSM - SAN
1 stop24h 11mMultiple Airlines
Sat 1/39:32 amSAN - DSM
1 stop28h 08mMultiple Airlines
Deal found 12/26$752
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:20 pmDSM - SAN
1 stop16h 28mAmerican Airlines
Tue 12/309:50 amSAN - DSM
1 stop12h 39mAmerican Airlines
Deal found 12/26$765

Find flight deals from Iowa to San Diego

Keep the following information in mind while searching for Iowa to San Diego flight deals. Data was last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$131
(Kiwi.com)

One-way from

$52
(Trip.com)

Popular in

March

Cheapest in

June

Average price

$419
Provider with most accurate pricing for Des Moines-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-San Diego flights.
Search Deals
From Iowa to San Diego
Search Deals
One-way flight from Iowa to San Diego
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Iowa to San Diego that are best for you.

Fly from

Iowa

Fly to

San Diego

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 2/13

7:17 pm-11:28 am

1 stop18h 11m

San Diego

Fri 2/20

8:35 am-6:19 pm

1 stop7h 44m

$131

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 2/19

11:32 am-11:39 pm

2 stops38h 07m

San Diego

Mon 2/23

6:25 am-6:34 pm

1 stop10h 09m

$195

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 1/8

8:30 am-1:29 pm

1 stop6h 59m

San Diego

Mon 1/12

6:36 am-7:22 pm

1 stop10h 46m

$239

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 2/26

3:11 pm-9:49 pm

1 stop8h 38m

San Diego

Mon 3/2

11:30 am-6:34 pm

1 stop5h 04m

$246

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Fri 1/9

1:11 pm-2:34 pm

1 stop27h 23m

San Diego

Sat 1/17

2:57 pm-6:54 pm

2 stops25h 57m

$279

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Fri 2/6

5:29 pm-10:33 pm

1 stop7h 04m

San Diego

Sat 2/14

11:30 am-8:54 pm

1 stop7h 24m

$280

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Wed 2/11

12:16 pm-10:31 pm

2 stops12h 15m

San Diego

Wed 2/18

3:10 pm-10:43 pm

1 stop5h 33m

$282

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Sat 2/14

2:50 pm-10:49 pm

2 stops9h 59m

San Diego

Tue 2/17

10:10 pm-11:38 am

2 stops11h 28m

$287

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 1/21

5:50 pm-11:48 pm

1 stop7h 58m

San Diego

Tue 1/27

6:30 am-4:47 pm

1 stop8h 17m

$287

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 1/20

9:00 am-10:42 pm

2 stops15h 42m

San Diego

Tue 1/27

9:55 am-4:52 pm

1 stop4h 57m

$291

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 57 results
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Best time to book a flight from Iowa to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Diego

What is the cheapest month to book a flight from Iowa to San Diego?

Currently, August is the cheapest month in which you can book a flight from Iowa to San Diego (average of $100). Flying from Iowa to San Diego in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Iowa?

    San Diego (SAN) is the airport you will fly into if you book a flight from Iowa to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How popular is this Iowa to San Diego flight route?

    Within the past month, 1 users have taken a look at flights from Iowa to San Diego.

  • How long is the flight from Iowa to San Diego?

    A quick flight from Iowa to San Diego can take about 7h 04m. Frontier provides one of the quickest options available for as low as $280. The distance from Iowa to San Diego is about 1580 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to San Diego?

    The most popular route from Iowa to San Diego is Des Moines - San Diego. You may also consider Cedar Rapids - San Diego or Omaha Eppley Airfield - San Diego.

  • Can I find deals for flights from Iowa to San Diego that include hotel bookings?

    Yes. In addition to deals on Iowa to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Diego.

  • Can I find deals for business class flights from Iowa to San Diego?

    Yes. Cheapflights offers flight deals from Iowa to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Iowa to San Diego (average of $100). Flying from Iowa to San Diego in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for Iowa to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Iowa to San Diego

Discover the top 6 airlines that operate flights from Iowa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$104Average$170FlexibilityNo cancel feeOn-time88%
FrontierCheapest$116Average$269FlexibilityNo cancel feeOn-time62%
DeltaCheapest$148Average$352FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$395FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$253Average$414FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$303Average$468FlexibilityNo cancel feeOn-time63%

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