Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Greenville, North Carolina to San Diego as you normally would.
Departing on a Saturday is a good option for securing a great price. You can expect to save up to 32% when planning your travel around this day of the week.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, August can be a great choice for travel to San Diego. Flights to San Diego from Greenville, North Carolina in August are about $450 on average during August, but can be found for as low as $200.