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Roanoke

$274+ Cheap flights from Des Moines to Roanoke (DSM - ROA)

DSM — ROA
Sep 19 — Sep 261
Sat 9/19
Sat 9/26
1 adult, Economy
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Cheap flight deals from Des Moines to Roanoke

Cheapest flights from Des Moines to Roanoke

Sat 10/109:26 am -
1 stop5h 52m
Sat 10/176:10 pm -
1 stop6h 48m
Deal found 8/16$319
Tue 10/203:11 pm -
1 stop6h 48m
Sat 10/245:51 pm -
1 stop6h 44m
Deal found 8/19$399
Fri 10/93:11 pm -
1 stop6h 48m
Sun 10/116:49 am -
1 stop4h 42m
Deal found 8/16$460
Tue 10/61:14 pm -
1 stop6h 29m
Thu 10/86:41 am -
1 stop5h 01m
Deal found 8/16$547
Tue 9/292:46 pm -
2 stops8h 13m
Tue 10/66:38 pm -
1 stop4h 55m
Deal found 8/15$548
Tue 10/63:11 pm -
2 stops7h 33m
Thu 10/86:49 am -
1 stop6h 45m
Deal found 8/16$552

Find flight deals from Des Moines to Roanoke

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Delta)

One-way from

$274
(American Airlines)

Popular in

June

Cheapest in

September

Average price

$323
Provider with most accurate pricing for Des Moines-Roanoke flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Roanoke flights.
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From Des Moines to Roanoke
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One-way flight from Des Moines to Roanoke
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Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in August 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Tue 9/29

6:54 pm-11:59 pm

1 stop4h 05m

Roanoke

Tue 10/6

6:00 am-10:42 am

1 stop5h 42m

$319

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Sat 10/10

2:01 pm-11:44 pm

2 stops8h 43m

Roanoke

Sat 10/17

6:10 pm-11:58 pm

1 stop6h 48m

$339

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Tue 10/20

3:11 pm-10:59 pm

1 stop6h 48m

Roanoke

Sat 10/24

5:51 pm-11:35 pm

1 stop6h 44m

$399

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Fri 10/9

3:11 pm-10:59 pm

1 stop6h 48m

Roanoke

Sun 10/11

6:49 am-10:31 am

1 stop4h 42m

$460
Cheapest one-way
Quickest one-way

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Wed 10/21

11:22 am-5:45 pm

1 stop5h 23m

$274

Des MoinesRoanoke

DSM Des Moines - ROA Roanoke

DSMROA

Des Moines

Wed 10/21

6:00 am-7:07 pm

2 stops12h 07m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Sorted by cheapest first

Compare providers for flights from Des Moines to Roanoke

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Roanoke in August.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Roanoke flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Roanoke flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Roanoke flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Roanoke flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Roanoke flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Des Moines with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Roanoke

How much does it cost to fly round-trip from Des Moines to Roanoke?

Airfare is typical for this route at the moment.

Des Moines to Roanoke flights typically cost between $308 and $344 in October.
The cheapest round-trip price found within the last 5 days was $319 on American Airlines (Oct 10-Oct 17).

Reviews of airlines servicing Roanoke

Read through reviews of airlines operating flights from Des Moines to Roanoke, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,969 reviews

Boarding

7.5

Comfort

7.2

Overall

7.1

Entertainment

6.8

Crew

7.9

Food

6.4

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,969 reviews
American Airlines
7.1
Good
11,969 reviews

Boarding

7.5

Comfort

7.2

Overall

7.1

Entertainment

6.8

Crew

7.9

Food

6.4

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

  • How long is the flight from Des Moines to Roanoke?

    Airlines like Delta, American Airlines, and United Airlines fly from Des Moines to Roanoke in about 4h 05m. The time it takes to get you to your destination can typically vary by up to 4h 38m. There are 784 mi between Des Moines and Roanoke. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Des Moines to Roanoke round-trip?

    Our cheapest airline available from Des Moines to Roanoke is American Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. American Airlines is currently priced 27% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Roanoke that include hotel bookings?

    Yes. In addition to deals on Des Moines to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Roanoke.

  • Can I find deals for business class flights from Des Moines to Roanoke?

    Yes. Cheapflights offers flight deals from Des Moines to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Salem
Radford
Blacksburg
Christiansburg

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Des Moines to Roanoke

AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$381FlexibilityNo cancel feeOn-time71%

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