$284+ Cheap flights from Des Moines to Roanoke (DSM - ROA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ROA
Oct 31 — Nov 71
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Roanoke with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Roanoke
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Best
Last-minute
One-way
Cheapest flights from Des Moines to RoanokeExplore the most affordable flight options available from Des Moines to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
Explore the most affordable flight options available from Des Moines to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:23 am -
1 stop5h 59m
Tue 12/86:32 pm -
1 stop5h 58m
Deal found 9/29![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:07 pm -
1 stop4h 50m
Tue 10/206:38 pm -
1 stop4h 55m
Deal found 9/28![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:00 am -
1 stop5h 27m
Sat 10/176:10 pm -
1 stop6h 48m
Deal found 9/28![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
1 stop4h 26m
Sun 11/16:30 am -
1 stop5h 02m
Deal found 9/27![United Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:11 pm -
2 stops7h 33m
Sat 10/176:49 am -
1 stop4h 42m
Deal found 9/28![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:29 am -
2 stops9h 16m
Tue 10/206:15 am -
2 stops8h 15m
Deal found 10/1![American Airlines logo]()
$426
Best flights from Des Moines to RoanokeDiscover carefully curated flight deals from Des Moines to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
Discover carefully curated flight deals from Des Moines to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:38 am -
1 stop5h 06m
Tue 12/812:26 pm -
2 stops7h 35m
Deal found 9/29![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:07 pm -
1 stop4h 50m
Tue 10/206:38 pm -
1 stop4h 55m
Deal found 9/28![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
1 stop4h 26m
Sun 11/16:30 am -
1 stop5h 02m
Deal found 9/27![United Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:00 am -
1 stop5h 27m
Sat 10/176:10 pm -
1 stop6h 48m
Deal found 9/28![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:02 pm -
1 stop7h 03m
Wed 2/310:35 am -
1 stop4h 59m
Deal found 9/30![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:29 am -
2 stops9h 16m
Tue 10/206:15 am -
2 stops8h 15m
Deal found 10/1![American Airlines logo]()
$426
Last-minute flights from Des Moines to RoanokeDiscover last-minute flight deals from Des Moines to Roanoke. Data last updated October 1, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Roanoke. Data last updated October 1, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:11 pm -
1 stop6h 48m
Tue 10/135:51 pm -
1 stop4h 32m
Deal found 9/29![United Airlines logo]()
$797
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:00 am -
1 stop5h 27m
Sat 10/176:10 pm -
1 stop6h 48m
Deal found 9/28![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:11 pm -
2 stops7h 33m
Sat 10/176:49 am -
1 stop4h 42m
Deal found 9/28![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 am -
1 stop6h 43m
Mon 10/196:10 pm -
1 stop6h 48m
Deal found 9/30![American Airlines logo]()
$605
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:07 pm -
1 stop4h 50m
Tue 10/206:38 pm -
1 stop4h 55m
Deal found 9/28![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:29 am -
2 stops9h 16m
Tue 10/206:15 am -
2 stops8h 15m
Deal found 10/1![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
1 stop4h 26m
Sun 11/16:30 am -
1 stop5h 02m
Deal found 9/27![United Airlines logo]()
$373
One-way flights from Des Moines to RoanokeSearch for one-way flight options from Des Moines to Roanoke. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
Search for one-way flight options from Des Moines to Roanoke. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:07 pm -
1 stop4h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Delta logo]()
$284
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:00 am -
2 stops10h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:54 pm -
1 stop4h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Delta logo]()
$369
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:54 pm -
1 stop4h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Delta logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:11 pm -
2 stops7h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:10 am -
3 stops29h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Allegiant Air logo]()
$391
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:11 pm -
1 stop6h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:23 am -
2 stops8h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:30 pm -
3 stops41h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$416
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
2 stops34h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:30 pm -
3 stops41h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$445
Find flight deals from Des Moines to Roanoke
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Roanoke (ROA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (American Airlines) |
One-way from | $284 (Delta) |
Popular in | September |
Cheapest in | October |
Average price | $308 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Fri 11/6
4:07 pm-9:57 pm
1 stop4h 50m
Roanoke
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$284
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Fri 12/4
11:38 am-5:44 pm
1 stop5h 06m
Roanoke
Tue 12/8
12:26 pm-7:01 pm
2 stops7h 35m
$344
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Sat 10/17
4:07 pm-9:57 pm
1 stop4h 50m
Roanoke
Tue 10/20
6:38 pm-10:33 pm
1 stop4h 55m
$354
Quickest round-trip
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Fri 10/16
6:54 pm-12:27 am
1 stop4h 33m
Roanoke
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$369
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Tue 10/13
7:00 am-1:27 pm
1 stop5h 27m
Roanoke
Sat 10/17
6:10 pm-11:58 pm
1 stop6h 48m
$369
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Fri 10/23
6:54 pm-12:27 am
1 stop4h 33m
Roanoke
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$373
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Thu 10/29
8:00 am-1:26 pm
1 stop4h 26m
Roanoke
Sun 11/1
6:30 am-10:32 am
1 stop5h 02m
$373
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Thu 10/15
3:11 pm-10:59 pm
1 stop6h 48m
Roanoke
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$403
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Fri 11/6
7:23 am-5:05 pm
2 stops8h 42m
Roanoke
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$408
Des MoinesRoanoke
DSM Des Moines - ROA Roanoke
DSMROA
Des Moines
Sat 10/17
7:29 am-5:45 pm
2 stops9h 16m
Roanoke
Tue 10/20
6:15 am-1:30 pm
2 stops8h 15m
$426
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Roanoke
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Roanoke in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Roanoke flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Roanoke flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Roanoke flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Roanoke flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Roanoke flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Roanoke
Have a flexible travel schedule? Discover the best time to fly to Roanoke from Des Moines with our price prediction graph.
DSM-ROA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Roanoke
Get insights into the airlines that provide service to Roanoke. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Roanoke. Reviews last updated October 1, 2026.
Read through reviews of airlines operating flights from Des Moines to Roanoke, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.0
Boarding
7.4
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Overall
7.0
Boarding
7.4
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Roanoke?
Book flights to Roanoke if you plan to visit one of these locationsSalem
Blacksburg
Christiansburg
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Des Moines and Roanoke flights
Browse other Des Moines and Roanoke flight options. Last updated on October 1, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
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Other flights to Roanoke
Explore flights to Roanoke departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Top airline flying from Des Moines to Roanoke
Discover the top airline that operate flights from Des Moines to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$381 | FlexibilityNo cancel fee | On-time71% |