What are the cheapest airlines to fly from Spartanburg to Panama City one-way?

The cheapest airlines for a one-way flight from Spartanburg to Panama City are United Airlines ($241), American Airlines ($294), and Avianca ($905).

What is the cheapest day to fly from Spartanburg to Panama City?

Travelers seeking maximum savings on their Spartanburg to Panama City flight should consider departing on Friday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from Spartanburg to Panama City?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Spartanburg to Panama City.

How far in advance should I book a flight from Spartanburg to Panama City?

To save up to 43% on this flight, we recommend booking at least 53 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Spartanburg to Panama City from $513 1-2 weeks out and tickets from $706 for flights departing within the next 72 hours.

What is the cheapest month to fly from Spartanburg to Panama City?

September is one of the best times of the year to fly to Panama City from Spartanburg. Prices for September average $575 per person but you can even find prices for as low as $467. The most expensive prices can be found in the month of December. Opting for a September flight can save you 54% on your journey compared to booking in December

What airport do you fly into for flights to Panama City from Spartanburg?

Panama City Tocumen Intl (PTY) is the airport you will fly into if you book a flight from Spartanburg to Panama City. You should not have trouble finding flights to Tocumen Intl from Spartanburg; the airport handles an average of 0 inbound flights from Spartanburg per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Panama City airport from Spartanburg. It is only a 11.4 mi journey from Tocumen Intl (PTY) to Panama City’s city center.

Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?

Yes. In addition to deals on Spartanburg to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Spartanburg to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama City.

Can I find deals for business class flights from Spartanburg to Panama City?

Yes. Cheapflights offers flight deals from Spartanburg to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$224+ Flights from Spartanburg to Panama City

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Spartanburg to Panama City Tocumen Intl are usually found in September or May, booked 52 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Panama City

Round-trip from	$455 (Avianca Connect)
One-way from	$224 (Kiwi.com)
Popular in	December
Cheapest in	September
Average price	$569

From Spartanburg to Panama City Tocumen Intl

Search Deals

One-way flight from Spartanburg to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($111 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in June 2025

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Find flight deals from Spartanburg to Panama City

Cheapest flights from Spartanburg to Panama City
Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.

Wed 8/66:00 amCLT - PTY

2 stops19h 45mMultiple Airlines

Tue 8/123:20 amPTY - CLT

2 stops18h 10mMultiple Airlines

Deal found 6/25

$455

Thu 9/257:00 amCLT - PTY

1 stop12h 37mUnited Airlines

Mon 9/299:45 amPTY - CLT

1 stop10h 27mUnited Airlines

Deal found 6/25

$467

Thu 8/2810:25 pmCLT - PTY

1 stop17h 05mAmerican Airlines

Tue 9/23:30 pmPTY - CLT

2 stops15h 20mAmerican Airlines

Deal found 6/26

$472

Wed 12/107:00 amCLT - PTY

1 stop6h 52mDelta

Fri 12/193:17 pmPTY - CLT

1 stop8h 37mDelta

Deal found 6/25

$567

Wed 12/246:00 amCLT - PTY

1 stop7h 28mCopa Airlines

Wed 12/3110:29 pmPTY - CLT

1 stop11h 15mCopa Airlines

Deal found 6/26

$727

Thu 7/36:00 amCLT - PTY

2 stops33h 45mAvianca

Tue 7/83:40 pmPTY - CLT

2 stops17h 08mAvianca

Deal found 6/25

$1,125

Best flights from Spartanburg to Panama City
Discover carefully curated flight deals from Spartanburg to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 26, 2025.

Wed 8/66:00 amCLT - PTY

2 stops19h 45mMultiple Airlines

Mon 8/113:25 amPTY - CLT

2 stops17h 51mMultiple Airlines

Deal found 6/25

$455

Thu 9/257:00 amCLT - PTY

1 stop12h 37mUnited Airlines

Mon 9/299:45 amPTY - CLT

1 stop10h 27mUnited Airlines

Deal found 6/25

$467

Thu 8/2810:25 pmCLT - PTY

1 stop17h 05mAmerican Airlines

Tue 9/23:30 pmPTY - CLT

2 stops15h 20mAmerican Airlines

Deal found 6/26

$472

Wed 12/107:00 amCLT - PTY

1 stop6h 52mDelta

Fri 12/193:17 pmPTY - CLT

1 stop8h 37mDelta

Deal found 6/25

$567

Fri 9/1910:33 amCLT - PTY

2 stops29h 12mAvianca

Fri 9/263:25 amPTY - CLT

2 stops38h 32mAvianca

Deal found 6/26

$1,324

Last-minute flights from Spartanburg to Panama City
Discover last-minute flight deals from Spartanburg to Panama City. Data last updated June 26, 2025 and is based on user searches.

Thu 7/36:00 amCLT - PTY

2 stops33h 45mAvianca

Tue 7/83:40 pmPTY - CLT

2 stops17h 08mAvianca

Deal found 6/25

$1,125

Fri 7/49:41 amCLT - PTY

1 stop10h 21mDelta

Mon 7/72:28 pmPTY - CLT

1 stop8h 30mDelta

Deal found 6/26

$627

Sat 7/59:01 amCLT - PTY

1 stop12h 18mMultiple Airlines

Thu 7/1012:03 pmPTY - CLT

1 stop9h 13mMultiple Airlines

Deal found 6/25

$517

Sat 7/511:47 amCLT - PTY

1 stop7h 50mUnited Airlines

Wed 8/133:30 pmPTY - CLT

1 stop18h 30mUnited Airlines

Deal found 6/25

$577

Sat 7/56:00 amCLT - PTY

2 stops9h 15mAmerican Airlines

Wed 8/133:30 pmPTY - CLT

2 stops13h 59mAmerican Airlines

Deal found 6/25

$582

Thu 7/247:00 amCLT - PTY

1 stop10h 12mUnited Airlines

Mon 7/283:30 pmPTY - CLT

1 stop18h 30mUnited Airlines

Deal found 6/26

$507

Fri 7/255:17 amCLT - PTY

1 stop9h 58mAmerican Airlines

Sun 7/271:55 pmPTY - CLT

1 stop16h 31mAmerican Airlines

Deal found 6/26

$527

Sun 7/276:00 amCLT - PTY

2 stops16h 10mMultiple Airlines

Wed 8/63:20 amPTY - CLT

2 stops17h 56mMultiple Airlines

Deal found 6/25

$472

One-way flights from Spartanburg to Panama City
Search for one-way flight options from Spartanburg to Panama City. Find affordable one-way fares based on user searches. Data last updated June 26, 2025.

Thu 7/178:21 pmCLT - PTY

2 stops25h 49mMultiple Airlines

Deal found 6/25

$224

Thu 7/176:26 amCLT - PTY

1 stop8h 24mUnited Airlines

Deal found 6/25

$241

Sat 7/56:00 amCLT - PTY

2 stops9h 15mAmerican Airlines

Deal found 6/25

$294

Fri 12/1210:15 amCLT - PTY

2 stops34h 45mAvianca

Deal found 6/26

$905

Cheapflights Fare Finder

Use the filters below to find and compare flights from Spartanburg to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 8/6

6:00 am-12:45 am

2 stops19h 45m

Panama City Tocumen Intl

Tue 8/12

3:20 am-10:30 pm

2 stops18h 10m

$455

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 9/25

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 9/29

9:45 am-9:12 pm

1 stop10h 27m

$467

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 8/18

5:35 am-12:50 pm

1 stop8h 15m

Panama City Tocumen Intl

Mon 8/25

2:05 pm-12:59 pm

1 stop21h 54m

$470

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 8/28

10:25 pm-2:30 pm

1 stop17h 05m

Panama City Tocumen Intl

Tue 9/2

3:30 pm-7:50 am

2 stops15h 20m

$472

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 9/19

10:33 am-2:45 pm

2 stops29h 12m

Panama City Tocumen Intl

Fri 9/26

3:25 am-6:57 pm

2 stops38h 32m

$1,324

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/17

8:21 pm-9:10 pm

2 stops25h 49m

$224

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/17

6:26 am-1:50 pm

1 stop8h 24m

$241

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 7/5

6:00 am-2:15 pm

2 stops9h 15m

$294

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 12/12

10:15 am-9:00 pm

2 stops34h 45m

$905

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/25

Best time to book a flight from Spartanburg to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Spartanburg with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama City

How far ahead should I book a flight from Spartanburg to Panama City?

The best time to book flights from Spartanburg to Panama City is 52 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Spartanburg to Panama City?

Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Panama City as you normally would.

How much does it cost to fly round-trip from Spartanburg to Panama City?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,963 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,963 reviews

Delta

8.0

Very good

7,963 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,838 reviews

Delta

8.0

Very good

7,963 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,963 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Avianca

6.7

Okay

2,355 reviews

Delta

8.0

Very good

7,963 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Panama City from Spartanburg?
Panama City Tocumen Intl (PTY) is the airport you will fly into if you book a flight from Spartanburg to Panama City. You should not have trouble finding flights to Tocumen Intl from Spartanburg; the airport handles an average of 0 inbound flights from Spartanburg per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Panama City airport from Spartanburg. It is only a 11.4 mi journey from Tocumen Intl (PTY) to Panama City’s city center.
What are the cheapest airlines to fly from Spartanburg to Panama City one-way?
The cheapest airlines for a one-way flight from Spartanburg to Panama City are United Airlines ($241), American Airlines ($294), and Avianca ($905).
Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?
Yes. In addition to deals on Spartanburg to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Spartanburg to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama City.
Can I find deals for business class flights from Spartanburg to Panama City?
Yes. Cheapflights offers flight deals from Spartanburg to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Spartanburg to Panama City?
Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Spartanburg to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$285	Average$461	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$341	Average$562	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$352	Average$575	FlexibilityNo cancel fee	On-time71%

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$224+ Cheap flights from Spartanburg, SC to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Spartanburg to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Spartanburg to Panama City Tocumen Intl are usually found in September or May, booked 52 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Panama City

Keep the following information in mind while searching for Spartanburg to Panama City flight deals. Data was last updated June 26, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Spartanburg to Panama City

Cheapest flights from Spartanburg to Panama CityExplore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.

Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Spartanburg to Panama City that are best for you.

Best time to book a flight from Spartanburg to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Spartanburg with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama City

How far ahead should I book a flight from Spartanburg to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Panama City. Price data was last updated on June 20, 2025.

What is the cheapest month to book a flight from Spartanburg to Panama City?

What is the cheapest time of day to fly from SB1 to PTY?

Find hourly flight availability from Spartanburg to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 26, 2025.

How much does it cost to fly round-trip from Spartanburg to Panama City?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Spartanburg?

What are the cheapest airlines to fly from Spartanburg to Panama City one-way?

Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?

How can I find direct flights from Spartanburg to Panama City?

Can I find deals for business class flights from Spartanburg to Panama City?

What is the cheapest month to book a flight from Spartanburg to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Spartanburg to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Spartanburg to Panama City

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Cheapest flights from Spartanburg to Panama City
Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.