How popular is this San Francisco to Panama City flight route?

This flight path from San Francisco to Panama City Tocumen Intl was viewed by 106 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from San Francisco to Panama City?

Departing from San Francisco to Panama City will take you 11h 45m. Airlines will cover a distance of 3318 mi.

What are the cheapest airlines flying from San Francisco to Panama City round-trip?

Our cheapest airline available from San Francisco to Panama City is Delta. Our recent data shows that you can find tickets from as low as $387 on this airline. Additional options worth looking into are Avianca and Copa Airlines, starting at $404 and $504 round-trip. You may be able to fly from San Francisco to Panama City for 41% less than the average price by searching for these airlines.

Weekly flight availability from San Francisco to Panama City

The most flights from SFO to PTY are scheduled on a Monday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (5 on average).

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the cheapest flights from San Francisco to Panama City?

While on average a flight from San Francisco to Panama City is generally $733, our data shows the cheapest flight currently is $224. When looking at the most popular route, (San Francisco - Panama City Tocumen Intl), you can expect to pay $478 for that flight.

What are the most reliable airlines from San Francisco to Panama City?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from San Francisco to Panama City on time: EVA Air (84%), Copa Airlines (77%), United Airlines (77%).

What are the most popular airlines that fly from San Francisco to Panama City?

The most popular airlines flying from San Francisco to Panama City are American Airlines, Avianca and Copa Airlines. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from San Francisco to Panama City?

Flights from San Francisco to Panama City are found to be more expensive on Friday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City.

How far in advance should I book a flight from San Francisco to Panama City?

Travelers have found it’s best to book a flight 27 days in advance to save up to 41% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 27 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from San Francisco to Panama City 1-2 weeks in advance for as low as $525, or $980 for flights within the next 24 hours.

What is the cheapest month to fly from San Francisco to Panama City?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, August can be a great choice for travel to Panama City. Flights to Panama City from San Francisco in August are about $659 on average during August, but can be found for as low as $449.

What airports do I use to fly from San Francisco to Panama City?

To fly from San Francisco to Panama City, you need to book a flight from San Francisco (SFO) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from San Francisco take 7h 04m on average. When it comes time to book airfare, you have a few options: there are 5 outbound flights from San Francisco to Tocumen Intl offered by 5 different airlines.

Can I find deals for flights from San Francisco to Panama City that include hotel bookings?

Yes. In addition to deals on San Francisco to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Panama City.

Can I find deals for business class flights from San Francisco to Panama City?

Yes. Cheapflights offers flight deals from San Francisco to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$209+ Flights from San Francisco to Panama City

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from San Francisco to Panama City Tocumen Intl are usually found in August or May, booked 26 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from San Francisco to Panama City

Round-trip from	$484 (Priceline)
One-way from	$209 (FlightHub)
Popular in	December
Cheapest in	August
Average price	$631
Good round-trip deal	$492 or less
Good one-way deal	$323 or less

From San Francisco to Panama City Tocumen Intl

Search Deals

One-way flight from San Francisco to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($90 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

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Price to beat on a round-trip flight from San Francisco to Panama City Tocumen Intl.

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Price to beat on a one-way flight from San Francisco to Panama City Tocumen Intl.

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Find flight deals from San Francisco to Panama City

Cheapest flights from San Francisco to Panama City
Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Thu 10/22:30 amSFO - PTY

2 stops16h 40mAvianca

Tue 10/78:10 pmPTY - SFO

1 stop18h 25mAvianca

Deal found 9/10

$484

Mon 9/1512:05 amSFO - PTY

1 stop8h 20mAvianca

Fri 9/193:25 amPTY - SFO

2 stops21h 20mAvianca

Deal found 9/9

$489

Thu 9/112:20 pmSFO - PTY

1 stop18h 05mAvianca

Thu 9/183:40 pmPTY - SFO

1 stop9h 05mAvianca

Deal found 9/10

$494

Fri 10/172:20 pmSFO - PTY

2 stops24h 10mAvianca

Fri 10/312:55 amPTY - SFO

2 stops23h 25mAvianca

Deal found 9/10

$496

Tue 10/2112:05 amSFO - PTY

2 stops22h 40mAvianca

Mon 10/275:55 pmPTY - SFO

2 stops21h 05mAvianca

Deal found 9/10

$498

Mon 9/152:20 pmSFO - PTY

1 stop18h 05mAvianca

Mon 9/298:10 pmPTY - SFO

1 stop18h 25mAvianca

Deal found 9/11

$499

Sat 11/291:35 amSFO - PTY

1 stop14h 20mAvianca

Thu 12/113:35 pmPTY - SFO

1 stop9h 15mAvianca

Deal found 9/11

$501

Fri 10/1012:05 amSFO - PTY

1 stop32h 20mAvianca

Sat 10/183:40 pmPTY - SFO

1 stop10h 15mAvianca

Deal found 9/11

$506

Best flights from San Francisco to Panama City
Discover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Thu 10/92:30 amSFO - PTY

1 stop11h 45mAvianca

Mon 10/133:25 amPTY - SFO

2 stops21h 20mAvianca

Deal found 9/11

$484

Thu 11/2712:36 amSFO - PTY

Nonstop7h 10mCopa Airlines

Tue 12/26:27 pmPTY - SFO

Nonstop7h 50mCopa Airlines

Deal found 9/11

$637

Wed 2/188:45 amSFO - PTY

Nonstop7h 04mUnited Airlines

Mon 3/24:00 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Deal found 9/10

$659

Fri 2/2712:42 amSFO - PTY

Nonstop7h 04mCopa Airlines

Sat 3/76:27 pmPTY - SFO

Nonstop7h 49mCopa Airlines

Deal found 9/11

$637

Thu 1/88:45 amSFO - PTY

Nonstop7h 04mUnited Airlines

Sun 1/183:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Deal found 9/11

$659

Wed 1/2112:42 amSFO - PTY

Nonstop7h 04mCopa Airlines

Mon 1/266:27 pmPTY - SFO

Nonstop7h 53mCopa Airlines

Deal found 9/10

$637

Tue 12/168:45 amSFO - PTY

Nonstop7h 04mUnited Airlines

Thu 1/83:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Deal found 9/11

$659

Sat 1/2412:43 amSFO - PTY

1 stop11h 02mUnited Airlines

Thu 2/53:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Deal found 9/10

$663

Last-minute flights from San Francisco to Panama City
Discover last-minute flight deals from San Francisco to Panama City. Data last updated September 11, 2025 and is based on user searches.

Thu 9/112:20 pmSFO - PTY

1 stop18h 05mAvianca

Thu 9/183:40 pmPTY - SFO

1 stop9h 05mAvianca

Deal found 9/10

$494

Mon 9/1512:05 amSFO - PTY

1 stop8h 20mAvianca

Fri 9/193:25 amPTY - SFO

2 stops21h 20mAvianca

Deal found 9/9

$489

Mon 9/152:20 pmSFO - PTY

1 stop18h 05mAvianca

Mon 9/298:10 pmPTY - SFO

1 stop18h 25mAvianca

Deal found 9/11

$499

Thu 10/22:30 amSFO - PTY

2 stops16h 40mAvianca

Tue 10/78:10 pmPTY - SFO

1 stop18h 25mAvianca

Deal found 9/10

$484

Wed 10/812:05 amSFO - PTY

2 stops19h 05mAvianca

Thu 10/163:20 amPTY - SFO

2 stops21h 25mAvianca

Deal found 9/11

$501

Fri 10/1012:05 amSFO - PTY

1 stop32h 20mAvianca

Sat 10/183:40 pmPTY - SFO

1 stop10h 15mAvianca

Deal found 9/11

$506

Fri 10/172:20 pmSFO - PTY

2 stops24h 10mAvianca

Fri 10/312:55 amPTY - SFO

2 stops23h 25mAvianca

Deal found 9/10

$496

Tue 10/2112:05 amSFO - PTY

2 stops22h 40mAvianca

Mon 10/275:55 pmPTY - SFO

2 stops21h 05mAvianca

Deal found 9/10

$498

One-way flights from San Francisco to Panama City
Search for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Mon 10/1312:05 amSFO - PTY

1 stop8h 20mAvianca

Deal found 9/10

$209

Sun 9/2812:05 amSFO - PTY

1 stop14h 10mAvianca

Deal found 9/10

$210

Wed 10/222:20 pmSFO - PTY

1 stop18h 05mAvianca

Deal found 9/10

$219

Fri 10/102:20 pmSFO - PTY

1 stop18h 05mAvianca

Deal found 9/10

$220

Tue 11/181:35 amSFO - PTY

2 stops20h 05mAvianca

Deal found 9/10

$221

Thu 10/305:45 amSFO - PTY

3 stops30h 15mMultiple Airlines

Deal found 9/10

$225

Fri 10/312:20 pmSFO - PTY

1 stop18h 00mAvianca

Deal found 9/10

$230

Mon 12/111:10 pmSFO - PTY

1 stop8h 10mAvianca

Deal found 9/9

$231

Sun 11/3011:10 pmSFO - PTY

2 stops22h 30mAvianca

Deal found 9/10

$232

Wed 10/2912:10 amSFO - PTY

1 stop32h 10mAvianca

Deal found 9/10

$234

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 10/9

2:30 am-4:15 pm

1 stop11h 45m

Panama City Tocumen Intl

Mon 10/13

3:25 am-10:45 pm

2 stops21h 20m

$484

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 11/27

12:36 am-10:46 am

Nonstop7h 10m

Panama City Tocumen Intl

Tue 12/2

6:27 pm-11:17 pm

Nonstop7h 50m

$637

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Fri 2/27

12:42 am-10:46 am

Nonstop7h 04m

Panama City Tocumen Intl

Sat 3/7

6:27 pm-11:16 pm

Nonstop7h 49m

$637

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/21

12:42 am-10:46 am

Nonstop7h 04m

Panama City Tocumen Intl

Mon 1/26

6:27 pm-11:20 pm

Nonstop7h 53m

$637

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 2/18

8:45 am-6:49 pm

Nonstop7h 04m

Panama City Tocumen Intl

Mon 3/2

4:00 pm-8:54 pm

Nonstop7h 54m

$659

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 1/8

8:45 am-6:49 pm

Nonstop7h 04m

Panama City Tocumen Intl

Sun 1/18

3:35 pm-8:29 pm

Nonstop7h 54m

$659

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Tue 12/16

8:45 am-6:49 pm

Nonstop7h 04m

Panama City Tocumen Intl

Thu 1/8

3:35 pm-8:29 pm

Nonstop7h 54m

$659

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 1/24

12:43 am-2:45 pm

1 stop11h 02m

Panama City Tocumen Intl

Thu 2/5

3:35 pm-8:29 pm

Nonstop7h 54m

$663

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 10/27

12:10 am-10:20 am

1 stop8h 10m

$210

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 9/29

10:37 pm-9:10 pm

3 stops44h 33m

$210

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 14 results

The best insider tips for San Francisco to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your San Francisco to Panama City trip

Airports

SFO

Save time by ordering meals for pickup through the SFO2Go program during busy times.

PTY

Use Uber for quick and cost-effective transport from PTY to Panama City, generally cheaper than taxis.

Our travel experts

Taryn White

Expert on PTY

Harriet Baskas

Expert on SFO

Best time to book a flight from San Francisco to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Panama City

Prices

Airlines

How far ahead should I book a flight from San Francisco to Panama City?

The best time to book flights from San Francisco to Panama City is 26 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from San Francisco to Panama City?

Currently, October is the cheapest month in which you can book a flight from San Francisco to Panama City (average of $478). Flying from San Francisco to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to PTY?

It’s optimal to fly from San Francisco to Panama City at noon. By choosing this option you can save up to 35% on the cost of your flight, compared to a flight in the afternoon.

What is the cheapest day to fly from San Francisco to Panama City?

Travelers seeking maximum savings on their San Francisco to Panama City flight should consider departing on Saturday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, Copa Airlines, and United Airlines from San Francisco to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,960 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.6

Good

1,531 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,937 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Avianca

6.7

Okay

2,436 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What airports do I use to fly from San Francisco to Panama City?
To fly from San Francisco to Panama City, you need to book a flight from San Francisco (SFO) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from San Francisco take 7h 04m on average. When it comes time to book airfare, you have a few options: there are 5 outbound flights from San Francisco to Tocumen Intl offered by 5 different airlines.
How popular is this San Francisco to Panama City flight route?
This flight path from San Francisco to Panama City Tocumen Intl was viewed by 106 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from San Francisco to Panama City?
Departing from San Francisco to Panama City will take you 11h 45m. Airlines will cover a distance of 3318 mi.
What are the cheapest airlines flying from San Francisco to Panama City round-trip?
Our cheapest airline available from San Francisco to Panama City is Delta. Our recent data shows that you can find tickets from as low as $387 on this airline. Additional options worth looking into are Avianca and Copa Airlines, starting at $404 and $504 round-trip. You may be able to fly from San Francisco to Panama City for 41% less than the average price by searching for these airlines.
What are the most reliable airlines from San Francisco to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from San Francisco to Panama City on time: EVA Air (84%), Copa Airlines (77%), United Airlines (77%).
What are the cheapest flights from San Francisco to Panama City?
While on average a flight from San Francisco to Panama City is generally $733, our data shows the cheapest flight currently is $224. When looking at the most popular route, (San Francisco - Panama City Tocumen Intl), you can expect to pay $478 for that flight.
Can I find deals for flights from San Francisco to Panama City that include hotel bookings?
Yes. In addition to deals on San Francisco to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Panama City.
Can I find deals for business class flights from San Francisco to Panama City?
Yes. Cheapflights offers flight deals from San Francisco to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Panama City?
Currently, October is the cheapest month in which you can book a flight from San Francisco to Panama City (average of $478). Flying from San Francisco to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for San Francisco to Panama City

Complete your trip

Panama City car rentals

Panama City Tocumen Intl Airport car rentals

Casco Viejo car rentals

San Francisco car rentals

Bella Vista car rentals

Ancón car rentals

Calidonia car rentals

Parque Lefevre car rentals

Bethania car rentals

Santa Ana car rentals

Juan Diaz car rentals

Pueblo Nuevo car rentals

Other flights from San Francisco

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San Francisco to San Diego flights

San Francisco to Los Angeles flights

San Francisco to San Bernardino flights

Other flights to Panama City

Top 5 airlines flying from San Francisco to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$387	Average$547	FlexibilityNo cancel fee	On-timeN/A
Avianca	Cheapest$404	Average$555	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$504	Average$647	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$533	Average$700	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$544	Average$590	FlexibilityNo cancel fee	On-time71%

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$209+ Cheap flights from San Francisco (SFO) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Panama City Tocumen Intl are usually found in August or May, booked 26 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from San Francisco to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from San Francisco to Panama City

Cheapest flights from San Francisco to Panama CityExplore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.

The best insider tips for San Francisco to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your San Francisco to Panama City trip

Airports

SFO

PTY

Our travel experts

Best time to book a flight from San Francisco to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Panama City

How far ahead should I book a flight from San Francisco to Panama City?

What is the cheapest month to book a flight from San Francisco to Panama City?

What is the cheapest time of day to fly from SFO to PTY?

What is the cheapest day to fly from San Francisco to Panama City?

Weekly flight availability from San Francisco to Panama City

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, Copa Airlines, and United Airlines from San Francisco to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from San Francisco to Panama City?

How popular is this San Francisco to Panama City flight route?

How long is the flight from San Francisco to Panama City?

What are the cheapest airlines flying from San Francisco to Panama City round-trip?

What are the most reliable airlines from San Francisco to Panama City?

What are the cheapest flights from San Francisco to Panama City?

Can I find deals for flights from San Francisco to Panama City that include hotel bookings?

How can I find direct flights from San Francisco to Panama City?

Can I find deals for business class flights from San Francisco to Panama City?

What is the cheapest month to book a flight from San Francisco to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Francisco to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from San Francisco to Panama City

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Travel Smart

Cheapest flights from San Francisco to Panama City
Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.