$70+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Apr 27 — May 41
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Missouri with Cheapflights
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 3/27![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 3/27![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Mon 5/112:34 pm
MCI
- CLT
1 stop24h 51m
Frontier
Deal found 3/23![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Sat 5/238:08 pm
STL
- CLT
1 stop21h 06m
Frontier
Deal found 3/26![Frontier logo]()
$176
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Wed 6/36:51 pm
STL
- CLT
1 stop11h 34m
Frontier
Deal found 3/27![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/121:46 pm
CLT
- STL
1 stop19h 05m
Frontier
Mon 4/134:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/27![Frontier logo]()
$181
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:55 am
CLT
- STL
1 stop10h 11m
Frontier
Wed 6/104:10 pm
STL
- CLT
1 stop19h 07m
Frontier
Deal found 3/27![Frontier logo]()
$185
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Wed 5/136:54 pm
STL
- CLT
Nonstop2h 00m
American Airlines
Deal found 3/26![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Sat 5/26:53 pm
STL
- CLT
Nonstop1h 57m
American Airlines
Deal found 3/26![American Airlines logo]()
$190
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:45 pm
CLT
- STL
1 stop28h 34m
Frontier
Wed 4/154:59 pm
STL
- CLT
1 stop14h 34m
Frontier
Deal found 3/27![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:49 pm
CLT
- MCI
1 stop25h 09m
Frontier
Fri 4/172:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 3/23![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:31 am
CLT
- STL
1 stop14h 48m
Frontier
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Deal found 3/27![Frontier logo]()
$192
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:15 pm
CLT
- STL
1 stop5h 10m
Southwest
Sat 5/26:10 am
STL
- CLT
2 stops8h 00m
Southwest
Deal found 3/26![Southwest logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:21 pm
CHS
- STL
1 stop8h 58m
Multiple Airlines
Sun 4/194:59 pm
STL
- CHS
1 stop14h 44m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:35 am
CLT
- STL
1 stop3h 35m
Delta
Tue 5/196:00 am
STL
- CLT
1 stop4h 05m
Delta
Deal found 3/26![Delta logo]()
$264
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:09 am
CLT
- STL
2 stops11h 04m
United Airlines
Wed 5/137:09 pm
STL
- CLT
1 stop4h 36m
United Airlines
Deal found 3/26![United Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:20 pm
CHS
- MCI
1 stop5h 58m
American Airlines
Wed 5/136:28 pm
MCI
- CHS
1 stop4h 31m
American Airlines
Deal found 3/23![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:05 pm
GSP
- MCI
1 stop6h 35m
Southwest
Tue 4/284:15 pm
MCI
- GSP
1 stop4h 25m
Southwest
Deal found 3/24![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:20 pm
CLT
- MCI
1 stop4h 20m
Southwest
Tue 4/284:15 pm
MCI
- CLT
1 stop4h 25m
Southwest
Deal found 3/23![Southwest logo]()
$240
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:40 am
CAE
- STL
1 stop3h 39m
Delta
Sat 6/138:00 am
STL
- CAE
1 stop6h 09m
Delta
Deal found 3/27![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Mon 6/82:20 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 3/27![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:59 pm
SAV
- STL
1 stop4h 37m
Delta
Mon 5/49:59 am
STL
- SAV
1 stop3h 14m
Delta
Deal found 3/27![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Sun 6/76:55 pm
STL
- CLT
1 stop4h 50m
United Airlines
Deal found 3/28![United Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:10 am
CLT
- MCI
1 stop4h 50m
Southwest
Sat 5/27:10 am
MCI
- CLT
1 stop7h 00m
Southwest
Deal found 3/26![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:40 am
GSP
- MCI
2 stops11h 01m
United Airlines
Tue 5/55:15 pm
MCI
- GSP
1 stop4h 43m
United Airlines
Deal found 3/26![United Airlines logo]()
$332
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:32 pm
CHS
- MCI
1 stop6h 44m
American Airlines
Fri 5/85:52 pm
MCI
- CHS
1 stop5h 32m
American Airlines
Deal found 3/26![American Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:40 am
CAE
- STL
1 stop5h 04m
Delta
Tue 6/21:05 pm
STL
- CAE
1 stop8h 42m
Delta
Deal found 3/27![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:40 am
CHS
- STL
2 stops8h 35m
Southwest
Fri 4/244:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Deal found 3/25![Southwest logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:25 am
GSP
- MCI
1 stop10h 11m
Multiple Airlines
Sun 8/26:57 pm
MCI
- GSP
1 stop18h 28m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:40 pm
CAE
- STL
1 stop4h 46m
United Airlines
Sun 6/287:22 am
STL
- CAE
1 stop5h 24m
United Airlines
Deal found 3/24![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:30 pm
SAV
- STL
1 stop7h 10m
Southwest
Mon 5/42:10 pm
STL
- SAV
1 stop6h 05m
Southwest
Deal found 3/24![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:40 am
CAE
- MCI
1 stop6h 36m
Delta
Tue 6/93:38 pm
MCI
- CAE
1 stop7h 07m
Delta
Deal found 3/25![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:00 am
SAV
- STL
1 stop5h 22m
United Airlines
Sun 4/127:45 am
STL
- SAV
1 stop5h 55m
United Airlines
Deal found 3/24![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:40 am
CLT
- STL
2 stops8h 45m
Southwest
Tue 6/239:40 am
STL
- CLT
2 stops7h 00m
Southwest
Deal found 3/23![Southwest logo]()
$272
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:22 am
CHS
- STL
2 stops11h 30m
United Airlines
Fri 4/249:10 am
STL
- CHS
2 stops13h 49m
United Airlines
Deal found 3/26![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:45 am
CAE
- STL
1 stop4h 49m
Delta
Sun 4/267:25 am
STL
- CAE
1 stop4h 49m
Delta
Deal found 3/24![Delta logo]()
$357
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:21 pm
CAE
- MCI
1 stop6h 05m
American Airlines
Mon 6/14:11 pm
MCI
- CAE
1 stop5h 05m
American Airlines
Deal found 3/25![American Airlines logo]()
$483
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
MYR
- MCI
1 stop4h 29m
Delta
Mon 6/15:13 pm
MCI
- MYR
1 stop5h 45m
Delta
Deal found 3/26![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:30 pm
CLT
- STL
1 stop3h 45m
Southwest
Sun 5/311:40 am
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 3/24![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:22 am
CHS
- STL
2 stops11h 30m
United Airlines
Sun 4/266:30 am
STL
- CHS
1 stop6h 25m
United Airlines
Deal found 3/24![United Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:34 am
CAE
- MCI
1 stop4h 51m
Delta
Wed 4/228:10 am
MCI
- CAE
1 stop4h 04m
Delta
Deal found 3/27![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:25 pm
CLT
- STL
1 stop6h 32m
United Airlines
Sat 5/231:13 pm
STL
- CLT
2 stops9h 46m
United Airlines
Deal found 3/26![United Airlines logo]()
$365
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated March 28, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated March 28, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:52 am
CLT
- STL
1 stop12h 33m
Frontier
Fri 4/108:41 am
STL
- CLT
1 stop14h 55m
Frontier
Deal found 3/24![Frontier logo]()
$201
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:49 pm
CLT
- STL
1 stop25h 36m
Frontier
Sun 4/124:59 pm
STL
- CLT
1 stop15h 38m
Frontier
Deal found 3/27![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/121:46 pm
CLT
- STL
1 stop19h 05m
Frontier
Mon 4/134:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/27![Frontier logo]()
$181
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:49 pm
CLT
- MCI
1 stop25h 09m
Frontier
Fri 4/172:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 3/23![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:45 pm
CLT
- STL
1 stop28h 34m
Frontier
Wed 4/154:59 pm
STL
- CLT
1 stop14h 34m
Frontier
Deal found 3/27![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:31 am
CLT
- STL
1 stop14h 48m
Frontier
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Deal found 3/27![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Mon 5/112:34 pm
MCI
- CLT
1 stop24h 51m
Frontier
Deal found 3/23![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 3/27![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 3/27![Frontier logo]()
$171
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Sat 5/26:53 pm
STL
- CLT
Nonstop1h 57m
American Airlines
Deal found 3/26![American Airlines logo]()
$190
This Frontier deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:51 pm
CLT
- STL
1 stop26h 30m
Frontier
Mon 4/274:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/28![Frontier logo]()
$202
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Wed 5/136:54 pm
STL
- CLT
Nonstop2h 00m
American Airlines
Deal found 3/26![American Airlines logo]()
$189
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/27![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/25![Frontier logo]()
$76
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/25![Frontier logo]()
$82
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/24![Frontier logo]()
$82
This Frontier deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/28![Frontier logo]()
$90
This Trip.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:33 pm
CLT
- STL
1 stop8h 25m
Frontier
Deal found 3/26![Frontier logo]()
$93
This Priceline deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:55 am
CLT
- STL
1 stop10h 11m
Frontier
Deal found 3/27![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/24![Frontier logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:20 pm
CLT
- MCI
1 stop21h 29m
Frontier
Deal found 3/24![Frontier logo]()
$98
This Trip.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:49 pm
CLT
- STL
1 stop24h 32m
Frontier
Deal found 3/27![Frontier logo]()
$99
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:49 pm
CLT
- MCI
1 stop25h 09m
Frontier
Deal found 3/24![Frontier logo]()
$102
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:10 am
CLT
- STL
1 stop6h 50m
Southwest
Deal found 3/24![Southwest logo]()
$105
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated March 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $151 (CheapOair) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | August |
Average price | $494 |
Good round-trip deal | $366 or less |
Good one-way deal | $179 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 4/25
12:15 pm-4:25 pm
1 stop5h 10m
Lambert-St Louis
Sat 5/2
6:10 am-3:10 pm
2 stops8h 00m
$214
GreenvilleKansas City
GSP - MCI
GSPMCI
Greenville
Tue 4/21
5:05 pm-10:40 pm
1 stop6h 35m
Kansas City
Tue 4/28
4:15 pm-9:40 pm
1 stop4h 25m
$225
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Tue 4/21
7:20 pm-10:40 pm
1 stop4h 20m
Kansas City
Tue 4/28
4:15 pm-9:40 pm
1 stop4h 25m
$240
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Mon 6/1
7:55 pm-11:15 pm
1 stop4h 20m
Lambert-St Louis
Mon 6/8
2:20 pm-5:20 pm
Nonstop2h 00m
$249
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Fri 4/17
3:21 pm-11:19 pm
1 stop8h 58m
Lambert-St Louis
Sun 4/19
4:59 pm-8:43 am
1 stop14h 44m
$259
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Sat 4/25
8:10 am-12:00 pm
1 stop4h 50m
Kansas City
Sat 5/2
7:10 am-3:10 pm
1 stop7h 00m
$259
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 5/15
5:35 am-8:10 am
1 stop3h 35m
Lambert-St Louis
Tue 5/19
6:00 am-11:05 am
1 stop4h 05m
$264
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Wed 4/22
7:40 am-3:15 pm
2 stops8h 35m
Lambert-St Louis
Fri 4/24
4:00 pm-9:30 pm
1 stop4h 30m
$265
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Thu 4/30
4:30 pm-10:40 pm
1 stop7h 10m
Lambert-St Louis
Mon 5/4
2:10 pm-9:15 pm
1 stop6h 05m
$267
ColumbiaSt. Louis
CAE - STL
CAESTL
Columbia Metropolitan
Sat 6/6
5:40 am-8:19 am
1 stop3h 39m
Lambert-St Louis
Sat 6/13
8:00 am-3:09 pm
1 stop6h 09m
$271
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CLT-STL
SAV-STL
GSP-MCI
CAE-STL
CHS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CLT-STL
SAV-STL
GSP-MCI
CAE-STL
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2026.
It’s optimal to fly from South Carolina to Missouri in the afternoon. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight at noon.
What is the cheapest day to fly from South Carolina to Missouri?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Missouri. Price data was last updated on March 23, 2026.
Travelers seeking maximum savings on their South Carolina to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from South Carolina to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 28, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on March 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$177 | Average$397 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$226 | Average$421 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$353 | FlexibilityNo cancel fee | On-time69% |