How popular is this South Carolina to Missouri flight route?

The South Carolina to Missouri flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from South Carolina to Missouri?

A quick flight from South Carolina to Missouri can take about 4h 10m. Southwest provides one of the quickest options available for as low as $143. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from South Carolina to Missouri one-way?

One-way options have recently been found by users for as low as $74 on Delta. Other airlines that offer cheap prices include American Airlines from $93 and Spirit Airlines from $94 one-way.

In terms of precipitation, rainfall in Missouri ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit Missouri when rainfall is around 2.2 in.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Missouri?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

Can I find deals for business class flights from South Carolina to Missouri?

Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$64+ Flights from South Carolina to Missouri

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheap flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.

Sat 12/209:02 pmCLT - STL

1 stop26h 31mFrontier

Mon 12/229:07 amSTL - CLT

1 stop6h 54mFrontier

Deal found 12/5

$175

Tue 12/309:00 amCLT - MCI

1 stop9h 10mMultiple Airlines

Sun 1/48:45 pmMCI - CLT

1 stop13h 37mMultiple Airlines

Deal found 12/5

$211

Wed 12/249:38 pmCLT - MCI

1 stop20h 32mMultiple Airlines

Thu 1/16:15 pmMCI - CLT

1 stop18h 57mMultiple Airlines

Deal found 12/4

$219

Fri 12/1210:33 pmCLT - STL

1 stop25h 00mFrontier

Sun 12/143:30 pmSTL - CLT

1 stop5h 08mFrontier

Deal found 12/5

$224

Tue 12/910:45 amCLT - STL

1 stop12h 48mFrontier

Tue 12/163:30 pmSTL - CLT

1 stop17h 20mFrontier

Deal found 12/6

$225

Thu 12/1110:33 pmCLT - STL

1 stop11h 26mFrontier

Mon 12/159:54 amSTL - CLT

1 stop9h 31mFrontier

Deal found 12/6

$234

Thu 12/1110:33 pmCLT - STL

1 stop11h 26mFrontier

Sat 12/137:43 pmSTL - CLT

1 stop20h 06mFrontier

Deal found 12/5

$246

Thu 12/1110:33 pmCLT - STL

1 stop11h 26mFrontier

Sun 12/143:30 pmSTL - CLT

1 stop17h 07mFrontier

Deal found 12/7

$251

Sat 12/206:26 pmCLT - STL

Nonstop2h 04mAmerican Airlines

Sat 1/37:05 amSTL - CLT

Nonstop2h 02mAmerican Airlines

Deal found 12/4

$252

Wed 12/244:11 pmCLT - MCI

1 stop25h 15mFrontier

Thu 1/15:11 pmMCI - CLT

1 stop23h 30mFrontier

Deal found 12/5

$252

Tue 12/1610:45 amCLT - STL

1 stop12h 48mMultiple Airlines

Tue 12/2310:48 amSTL - CLT

2 stops32h 21mMultiple Airlines

Deal found 12/7

$255

Tue 12/162:59 pmCHS - STL

1 stop8h 34mMultiple Airlines

Sun 12/2110:57 amSTL - CHS

2 stops33h 26mMultiple Airlines

Deal found 12/6

$258

Best flights from South Carolina to Missouri
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 7, 2025.

Wed 1/145:50 pmCLT - STL

1 stop4h 10mSouthwest

Sat 1/171:45 pmSTL - CLT

1 stop4h 30mSouthwest

Deal found 12/4

$143

Mon 2/210:32 amGSP - MCI

1 stop6h 42mAmerican Airlines

Wed 2/41:56 pmMCI - GSP

1 stop6h 00mAmerican Airlines

Deal found 12/4

$192

Tue 1/273:01 pmCHS - STL

1 stop9h 32mMultiple Airlines

Sat 1/318:22 pmSTL - CHS

2 stops18h 48mMultiple Airlines

Deal found 12/7

$195

Fri 5/15:30 amSAV - STL

1 stop3h 37mDelta

Mon 5/49:00 amSTL - SAV

1 stop7h 44mDelta

Deal found 12/5

$237

Mon 1/198:19 pmCLT - STL

1 stop28h 14mFrontier

Thu 1/225:42 pmSTL - CLT

1 stop14h 48mFrontier

Deal found 12/6

$244

Mon 1/262:55 pmGSP - MCI

1 stop6h 01mUnited Airlines

Thu 1/2911:29 amMCI - GSP

1 stop4h 23mUnited Airlines

Deal found 12/4

$285

Fri 12/1910:18 pmCHS - MCI

1 stop19h 52mSpirit Airlines

Sun 12/216:15 pmMCI - CHS

1 stop26h 08mSpirit Airlines

Deal found 12/6

$326

Mon 1/196:05 amGSP - STL

1 stop5h 46mAmerican Airlines

Wed 1/216:52 amSTL - GSP

1 stop5h 25mAmerican Airlines

Deal found 12/4

$198

Tue 1/2711:35 amCLT - MCI

1 stop29h 34mMultiple Airlines

Fri 1/3011:26 amMCI - CLT

1 stop8h 32mMultiple Airlines

Deal found 12/6

$217

Tue 1/135:50 pmCLT - STL

1 stop4h 10mSouthwest

Wed 1/142:30 pmSTL - CLT

Nonstop1h 45mSouthwest

Deal found 12/6

$227

Thu 2/195:25 amCLT - STL

1 stop4h 41mDelta

Wed 3/410:12 amSTL - CLT

1 stop4h 53mDelta

Deal found 12/6

$248

Tue 1/138:25 amCLT - STL

Nonstop2h 10mSouthwest

Mon 1/192:55 pmSTL - CLT

Nonstop1h 45mSouthwest

Deal found 12/5

$228

Tue 12/1610:45 amCLT - STL

1 stop12h 48mMultiple Airlines

Tue 12/2310:48 amSTL - CLT

2 stops32h 21mMultiple Airlines

Deal found 12/7

$255

Mon 3/167:59 pmSAV - STL

1 stop4h 43mDelta

Thu 3/196:00 amSTL - SAV

1 stop6h 02mDelta

Deal found 12/6

$258

Thu 1/84:46 pmSAV - STL

1 stop7h 12mUnited Airlines

Mon 1/123:11 pmSTL - SAV

1 stop5h 25mUnited Airlines

Deal found 12/4

$287

Tue 1/136:10 amCHS - STL

1 stop4h 30mAmerican Airlines

Tue 1/133:20 pmSTL - CHS

1 stop5h 23mAmerican Airlines

Deal found 12/5

$273

Tue 1/208:25 amCLT - STL

Nonstop2h 10mSouthwest

Fri 1/2310:35 amSTL - CLT

1 stop6h 55mSouthwest

Deal found 12/5

$250

Thu 12/252:30 pmCAE - MCI

1 stop6h 12mUnited Airlines

Thu 1/16:35 pmMCI - CAE

1 stop4h 51mUnited Airlines

Deal found 12/6

$293

Sat 1/35:30 amSAV - STL

1 stop4h 28mDelta

Tue 1/66:00 amSTL - SAV

1 stop6h 46mDelta

Deal found 12/4

$268

Mon 1/195:05 pmCLT - STL

Nonstop2h 10mSouthwest

Thu 1/222:30 pmSTL - CLT

Nonstop1h 45mSouthwest

Deal found 12/6

$251

Sun 12/2110:18 pmCHS - MCI

2 stops25h 41mSpirit Airlines

Sat 12/276:15 pmMCI - CHS

1 stop26h 08mSpirit Airlines

Deal found 12/4

$352

Tue 12/309:24 pmCLT - MCI

2 stops20h 46mMultiple Airlines

Sun 1/48:45 pmMCI - CLT

1 stop13h 37mMultiple Airlines

Deal found 12/5

$291

Tue 1/135:34 pmGSP - STL

1 stop6h 24mUnited Airlines

Wed 1/149:57 amSTL - GSP

2 stops8h 32mUnited Airlines

Deal found 12/6

$298

Thu 12/257:05 amCAE - MCI

2 stops10h 05mAmerican Airlines

Thu 1/16:36 pmMCI - CAE

1 stop4h 31mAmerican Airlines

Deal found 12/6

$300

Thu 3/55:07 pmCAE - MCI

1 stop5h 51mDelta

Sat 3/71:00 pmMCI - CAE

1 stop4h 25mDelta

Deal found 12/5

$277

Mon 1/196:40 pmGSP - STL

1 stop5h 00mSouthwest

Wed 1/218:20 amSTL - GSP

2 stops8h 15mSouthwest

Deal found 12/4

$253

Mon 12/228:54 amCLT - MCI

1 stop9h 16mMultiple Airlines

Tue 12/236:15 pmMCI - CLT

1 stop25h 18mMultiple Airlines

Deal found 12/5

$301

Fri 2/1310:25 pmCLT - MCI

Nonstop2h 34mAmerican Airlines

Sun 2/1512:16 pmMCI - CLT

Nonstop2h 21mAmerican Airlines

Deal found 12/6

$303

Sat 3/76:59 pmCLT - MCI

1 stop5h 55mDelta

Wed 3/116:35 amMCI - CLT

1 stop4h 22mDelta

Deal found 12/5

$283

Fri 5/111:26 amSAV - STL

1 stop4h 55mUnited Airlines

Mon 5/47:45 amSTL - SAV

2 stops10h 35mUnited Airlines

Deal found 12/6

$312

Last-minute flights from South Carolina to Missouri
Discover last-minute flight deals from South Carolina to Missouri. Data last updated December 7, 2025 and is based on user searches.

Sat 12/209:02 pmCLT - STL

1 stop26h 31mFrontier

Mon 12/229:07 amSTL - CLT

1 stop6h 54mFrontier

Deal found 12/5

$175

Fri 1/96:50 pmCLT - STL

1 stop16h 12mFrontier

Sun 1/115:11 pmSTL - CLT

1 stop14h 51mFrontier

Deal found 12/5

$174

Fri 1/911:12 amCLT - MCI

1 stop5h 57mSpirit Airlines

Mon 1/1211:26 amMCI - CLT

1 stop6h 22mSpirit Airlines

Deal found 12/5

$178

Tue 1/138:46 pmCLT - STL

1 stop26h 48mMultiple Airlines

Mon 1/195:11 pmSTL - CLT

1 stop22h 43mMultiple Airlines

Deal found 12/5

$194

Wed 1/1410:09 pmCLT - STL

Nonstop2h 03mAmerican Airlines

Sat 1/178:13 amSTL - CLT

Nonstop1h 58mAmerican Airlines

Deal found 12/4

$123

Wed 1/145:50 pmCLT - STL

1 stop4h 10mSouthwest

Sat 1/171:45 pmSTL - CLT

1 stop4h 30mSouthwest

Deal found 12/4

$143

Wed 1/145:04 pmCLT - STL

1 stop6h 30mFrontier

Wed 1/215:42 pmSTL - CLT

1 stop23h 17mFrontier

Deal found 12/5

$154

Wed 1/146:00 amCLT - STL

2 stops17h 34mMultiple Airlines

Wed 1/215:42 pmSTL - CLT

1 stop23h 17mMultiple Airlines

Deal found 12/5

$189

Wed 1/1410:09 pmCLT - STL

Nonstop2h 03mAmerican Airlines

Wed 1/218:13 amSTL - CLT

Nonstop1h 58mAmerican Airlines

Deal found 12/5

$193

Tue 1/2011:35 amCLT - STL

1 stop12h 58mFrontier

Fri 1/2311:18 amSTL - CLT

1 stop5h 49mFrontier

Deal found 12/5

$157

Tue 1/209:07 pmCLT - STL

2 stops27h 26mMultiple Airlines

Fri 1/235:42 pmSTL - CLT

1 stop15h 13mMultiple Airlines

Deal found 12/5

$196

Tue 1/273:01 pmCHS - STL

1 stop9h 32mMultiple Airlines

Sat 1/315:42 pmSTL - CHS

1 stop13h 56mMultiple Airlines

Deal found 12/7

$173

One-way flights from South Carolina to Missouri
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated December 7, 2025.

Thu 2/56:54 pmCLT - STL

1 stop5h 39mFrontier

Deal found 12/7

$64

Mon 3/212:12 pmCLT - MCI

1 stop8h 39mFrontier

Deal found 12/5

$64

Sat 2/79:59 pmCLT - STL

1 stop11h 05mFrontier

Deal found 12/7

$70

Fri 2/63:21 pmCHS - STL

1 stop9h 12mMultiple Airlines

Deal found 12/7

$72

Tue 2/33:01 pmCHS - STL

1 stop9h 32mMultiple Airlines

Deal found 12/5

$74

Tue 2/36:01 pmCLT - STL

1 stop6h 32mMultiple Airlines

Deal found 12/7

$75

Wed 2/43:05 pmSAV - STL

1 stop4h 29mAmerican Airlines

Deal found 12/4

$80

Wed 3/46:10 amCHS - STL

1 stop4h 33mAmerican Airlines

Deal found 12/4

$80

Wed 1/74:32 pmCLT - STL

1 stop7h 01mFrontier

Deal found 12/6

$81

Sat 3/712:17 pmCLT - MCI

1 stop8h 34mFrontier

Deal found 12/5

$81

Wed 12/312:51 pmCLT - STL

1 stop8h 42mFrontier

Deal found 12/5

$82

Wed 2/41:35 pmCLT - MCI

1 stop8h 35mSouthwest

Deal found 12/5

$84

Find flight deals from South Carolina to Missouri

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$123 (American Airlines)
One-way from	$64 (Frontier)
Popular in	December
Cheapest in	August
Average price	$529

Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.

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From South Carolina to Missouri

Search Deals

One-way flight from South Carolina to Missouri

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 1/14

5:50 pm-9:00 pm

1 stop4h 10m

Lambert-St Louis

Sat 1/17

1:45 pm-7:15 pm

1 stop4h 30m

$143

GreenvilleKansas City

GSP - MCI

GSPMCI

Greenville

Mon 2/2

10:32 am-4:14 pm

1 stop6h 42m

Kansas City

Wed 2/4

1:56 pm-8:56 pm

1 stop6h 00m

$192

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 1/27

3:01 pm-11:33 pm

1 stop9h 32m

Lambert-St Louis

Sat 1/31

8:22 pm-4:10 pm

2 stops18h 48m

$195

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Mon 1/19

6:05 am-10:51 am

1 stop5h 46m

Lambert-St Louis

Wed 1/21

6:52 am-1:17 pm

1 stop5h 25m

$198

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Tue 1/27

11:35 am-4:09 pm

1 stop29h 34m

Kansas City

Fri 1/30

11:26 am-8:58 pm

1 stop8h 32m

$217

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 1/13

5:50 pm-9:00 pm

1 stop4h 10m

Lambert-St Louis

Wed 1/14

2:30 pm-5:15 pm

Nonstop1h 45m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 1/13

8:25 am-9:35 am

Nonstop2h 10m

Lambert-St Louis

Mon 1/19

2:55 pm-5:40 pm

Nonstop1h 45m

$228

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Fri 5/1

5:30 am-8:07 am

1 stop3h 37m

Lambert-St Louis

Mon 5/4

9:00 am-5:44 pm

1 stop7h 44m

$237

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 1/19

8:19 pm-11:33 pm

1 stop28h 14m

Lambert-St Louis

Thu 1/22

5:42 pm-9:30 am

1 stop14h 48m

$244

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 2/19

5:25 am-9:06 am

1 stop4h 41m

Lambert-St Louis

Wed 3/4

10:12 am-4:05 pm

1 stop4h 53m

$248

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

It’s optimal to fly from South Carolina to Missouri in the evening. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from South Carolina to Missouri?

Travelers seeking maximum savings on their South Carolina to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,252 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,013 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,076 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,042 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Spirit Airlines

6.3

Okay

8,169 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How popular is this South Carolina to Missouri flight route?
The South Carolina to Missouri flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from South Carolina to Missouri?
A quick flight from South Carolina to Missouri can take about 4h 10m. Southwest provides one of the quickest options available for as low as $143. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from South Carolina to Missouri one-way?
One-way options have recently been found by users for as low as $74 on Delta. Other airlines that offer cheap prices include American Airlines from $93 and Spirit Airlines from $94 one-way.
Can I find deals for flights from South Carolina to Missouri that include hotel bookings?
Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Missouri?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.
Can I find deals for business class flights from South Carolina to Missouri?
Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from South Carolina to Missouri

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$139	Average$357	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$174	Average$318	FlexibilityNo cancel fee	On-time69%
Spirit Airlines	Cheapest$199	Average$254	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$204	Average$386	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$226	Average$431	FlexibilityNo cancel fee	On-time63%

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$64+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Missouri with Cheapflights

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Cheap flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.

Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.

Find flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated December 7, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 7, 2025.

What is the cheapest day to fly from South Carolina to Missouri?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Missouri. Price data was last updated on December 16, 2024.

Reviews of airlines servicing Missouri

Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this South Carolina to Missouri flight route?

How long is the flight from South Carolina to Missouri?

What are the cheapest airlines to fly from South Carolina to Missouri one-way?

Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

How can I find direct flights from South Carolina to Missouri?

Can I find deals for business class flights from South Carolina to Missouri?

What is the cheapest month to book a flight from South Carolina to Missouri?

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Alternative routes for South Carolina to Missouri

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Top 5 airlines flying from South Carolina to Missouri

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Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.