How popular is this South Carolina to Missouri flight route?

The South Carolina to Missouri flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines to fly from South Carolina to Missouri one-way?

One-way options have recently been found by users for as low as $95 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $114 and American Airlines from $128 one-way.

What is the cheapest month to fly from South Carolina to Missouri?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, February can be a great choice for travel to Missouri. Flights to Missouri from South Carolina in February are about $360 on average during February, but can be found for as low as $208.

Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Missouri?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

Can I find deals for business class flights from South Carolina to Missouri?

Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$95+ Flights from South Carolina to Missouri - Compare & Save Big

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Cheap flight deals from South Carolina to Missouri

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$180 (CheapOair)
One-way from	$95 (Frontier)
Popular in	December
Cheapest in	February
Average price	$340
Good round-trip deal	$400 or less
Good one-way deal	$164 or less

Provider with most accurate pricing for Myrtle Beach Intl-Kansas City flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Kansas City flights.

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From South Carolina to Missouri

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One-way flight from South Carolina to Missouri

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Highest demand for flights based on searches. 0% potential increase in price ($2 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

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Average for round-trip flights in May 2025

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Price to beat on a round-trip flight from South Carolina to Missouri.

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Price to beat on a one-way flight from South Carolina to Missouri.

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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Thu 5/1510:36 pmCLT - STL

1 stop26h 38mFrontier

Wed 5/215:45 pmSTL - CLT

1 stop15h 56mFrontier

Deal found 4/29

$180

Tue 6/35:44 amCAE - STL

1 stop4h 16mDelta

Tue 6/107:00 amSTL - CAE

1 stop6h 15mDelta

Deal found 4/30

$217

Sat 5/3111:23 amCLT - MCI

1 stop11h 07mSpirit Airlines

Tue 6/35:46 amMCI - CLT

1 stop9h 05mSpirit Airlines

Deal found 4/30

$218

Fri 5/233:14 pmCLT - STL

1 stop9h 38mMultiple Airlines

Sun 5/2510:10 amSTL - CLT

1 stop8h 47mMultiple Airlines

Deal found 4/29

$219

Thu 6/58:43 pmCAE - STL

1 stop4h 16mAmerican Airlines

Wed 6/115:37 amSTL - CAE

1 stop8h 10mAmerican Airlines

Deal found 4/30

$230

Tue 8/266:45 amGSP - SGF

1 stop5h 17mDelta

Sun 8/316:00 amSGF - GSP

1 stop4h 04mDelta

Deal found 4/29

$233

Thu 6/266:13 pmCLT - STL

1 stop23h 51mSpirit Airlines

Sun 6/296:12 pmSTL - CLT

1 stop15h 26mSpirit Airlines

Deal found 4/29

$235

Sun 6/82:32 pmCAE - MCI

1 stop20h 59mMultiple Airlines

Fri 6/1311:05 amMCI - CAE

1 stop28h 41mMultiple Airlines

Deal found 4/30

$244

Wed 7/232:43 pmSAV - SGF

1 stop4h 28mDelta

Sun 7/276:56 pmSGF - SAV

1 stop4h 03mDelta

Deal found 4/29

$249

Mon 6/27:59 pmCAE - MCI

1 stop5h 00mDelta

Sat 6/75:26 pmMCI - CAE

1 stop5h 32mDelta

Deal found 4/30

$249

Wed 6/1810:58 pmCLT - STL

Nonstop2h 01mAmerican Airlines

Tue 6/245:30 amSTL - CLT

Nonstop1h 55mAmerican Airlines

Deal found 4/29

$255

Sun 6/83:23 pmCAE - MCI

2 stops20h 25mSpirit Airlines

Fri 6/1311:05 amMCI - CAE

1 stop28h 41mSpirit Airlines

Deal found 4/30

$261

Best flights from South Carolina to Missouri
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Thu 5/1510:36 pmCLT - STL

1 stop26h 38mFrontier

Wed 5/215:45 pmSTL - CLT

1 stop15h 56mFrontier

Deal found 4/29

$180

Tue 6/35:44 amCAE - STL

1 stop4h 16mDelta

Tue 6/107:00 amSTL - CAE

1 stop6h 15mDelta

Deal found 4/30

$217

Sat 5/3111:23 amCLT - MCI

1 stop11h 07mSpirit Airlines

Tue 6/35:46 amMCI - CLT

1 stop9h 05mSpirit Airlines

Deal found 4/30

$218

Fri 5/233:14 pmCLT - STL

1 stop9h 38mMultiple Airlines

Sun 5/2510:10 amSTL - CLT

1 stop8h 47mMultiple Airlines

Deal found 4/29

$219

Thu 6/58:43 pmCAE - STL

1 stop4h 16mAmerican Airlines

Wed 6/115:37 amSTL - CAE

1 stop8h 10mAmerican Airlines

Deal found 4/30

$230

Tue 6/35:55 pmCHS - STL

Nonstop2h 20mSouthwest

Mon 6/911:10 amSTL - CHS

Nonstop1h 50mSouthwest

Deal found 4/30

$271

Tue 6/32:44 pmCHS - STL

2 stops9h 01mUnited Airlines

Mon 6/98:10 amSTL - CHS

1 stop4h 52mUnited Airlines

Deal found 4/30

$286

Tue 8/266:45 amGSP - SGF

1 stop5h 17mDelta

Sun 8/316:00 amSGF - GSP

1 stop4h 04mDelta

Deal found 4/29

$233

Thu 6/266:13 pmCLT - STL

1 stop23h 51mSpirit Airlines

Sun 6/296:12 pmSTL - CLT

1 stop15h 26mSpirit Airlines

Deal found 4/29

$235

Sun 6/82:32 pmCAE - MCI

1 stop20h 59mMultiple Airlines

Fri 6/1311:05 amMCI - CAE

1 stop28h 41mMultiple Airlines

Deal found 4/30

$244

Wed 6/1810:58 pmCLT - STL

Nonstop2h 01mAmerican Airlines

Tue 6/245:30 amSTL - CLT

Nonstop1h 55mAmerican Airlines

Deal found 4/29

$255

Sun 6/85:34 pmCLT - MCI

1 stop26h 32mFrontier

Wed 6/118:00 pmMCI - CLT

1 stop19h 33mFrontier

Deal found 4/30

$271

Last-minute flights from South Carolina to Missouri
Discover last-minute flight deals from South Carolina to Missouri. Data last updated May 1, 2025 and is based on user searches.

Mon 5/54:21 pmCLT - STL

1 stop8h 45mFrontier

Fri 5/95:55 pmSTL - CLT

1 stop22h 57mFrontier

Deal found 4/30

$200

Tue 5/67:00 amCAE - STL

1 stop5h 45mDelta

Sat 5/107:05 amSTL - CAE

1 stop4h 58mDelta

Deal found 4/30

$289

Tue 5/610:36 amCAE - STL

1 stop6h 11mUnited Airlines

Sat 5/106:30 amSTL - CAE

2 stops6h 42mUnited Airlines

Deal found 4/30

$364

Tue 5/68:22 amCLT - MCI

1 stop6h 04mDelta

Tue 5/135:45 amMCI - CLT

1 stop5h 49mDelta

Deal found 4/30

$403

Tue 5/610:24 amCLT - MCI

2 stops10h 30mUnited Airlines

Wed 5/143:30 pmMCI - CLT

1 stop4h 51mUnited Airlines

Deal found 4/30

$478

Wed 5/77:00 amCLT - MCI

1 stop6h 50mSouthwest

Wed 5/1412:45 pmMCI - CLT

1 stop7h 35mSouthwest

Deal found 4/30

$342

Wed 5/71:35 pmCLT - MCI

Nonstop2h 26mAmerican Airlines

Wed 5/146:15 amMCI - CLT

Nonstop2h 23mAmerican Airlines

Deal found 4/30

$383

Wed 5/72:37 pmCAE - STL

1 stop5h 46mAmerican Airlines

Tue 5/136:47 pmSTL - CAE

1 stop4h 07mAmerican Airlines

Deal found 4/30

$404

Wed 5/711:05 amCLT - MCI

3 stops27h 45mMultiple Airlines

Wed 5/142:45 pmMCI - CLT

2 stops25h 02mMultiple Airlines

Deal found 4/30

$450

Wed 5/79:12 amCLT - SGF

Nonstop2h 39mAmerican Airlines

Wed 5/147:05 amSGF - CLT

Nonstop2h 13mAmerican Airlines

Deal found 4/29

$481

Fri 5/96:40 amSAV - SGF

1 stop5h 04mAmerican Airlines

Mon 5/126:39 pmSGF - SAV

1 stop4h 17mAmerican Airlines

Deal found 4/30

$309

Fri 5/91:00 pmSAV - SGF

2 stops11h 30mUnited Airlines

Mon 5/125:45 amSGF - SAV

1 stop8h 24mUnited Airlines

Deal found 4/30

$384

One-way flights from South Carolina to Missouri
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Fri 5/164:21 pmCLT - STL

1 stop8h 53mFrontier

Deal found 4/30

$95

Wed 6/119:45 pmCLT - STL

1 stop20h 19mSpirit Airlines

Deal found 4/30

$114

Mon 6/161:10 pmCHS - STL

1 stop6h 08mSpirit Airlines

Deal found 4/30

$115

Tue 7/17:19 amCLT - STL

Nonstop1h 54mAmerican Airlines

Deal found 5/1

$128

Tue 7/17:45 pmCHS - STL

Nonstop2h 05mSouthwest

Deal found 5/1

$128

Mon 6/24:32 pmCLT - STL

2 stops27h 09mMultiple Airlines

Deal found 4/30

$131

Tue 7/16:20 amCHS - STL

1 stop3h 55mDelta

Deal found 4/29

$133

Tue 9/211:29 amGSP - MCI

1 stop5h 10mAmerican Airlines

Deal found 4/30

$136

Sun 6/85:34 pmCLT - MCI

1 stop26h 32mFrontier

Deal found 4/30

$137

Tue 7/15:10 pmCLT - STL

1 stop4h 20mDelta

Deal found 5/1

$138

Wed 6/46:00 amCHS - STL

2 stops10h 30mUnited Airlines

Deal found 4/30

$138

Tue 9/23:25 pmGSP - MCI

2 stops8h 00mSouthwest

Deal found 4/30

$141

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 5/15

10:36 pm-12:14 am

1 stop26h 38m

Lambert-St Louis

Wed 5/21

5:45 pm-10:41 am

1 stop15h 56m

$180

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Tue 6/3

5:44 am-9:00 am

1 stop4h 16m

Lambert-St Louis

Tue 6/10

7:00 am-2:15 pm

1 stop6h 15m

$217

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Sat 5/31

11:23 am-9:30 pm

1 stop11h 07m

Kansas City

Tue 6/3

5:46 am-3:51 pm

1 stop9h 05m

$218

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 5/23

3:14 pm-11:52 pm

1 stop9h 38m

Lambert-St Louis

Sun 5/25

10:10 am-7:57 pm

1 stop8h 47m

$219

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Thu 6/5

8:43 pm-11:59 pm

1 stop4h 16m

Lambert-St Louis

Wed 6/11

5:37 am-2:47 pm

1 stop8h 10m

$230

GreenvilleSpringfield

GSP - SGF

GSPSGF

Greenville

Tue 8/26

6:45 am-11:02 am

1 stop5h 17m

Springfield-Branson

Sun 8/31

6:00 am-11:04 am

1 stop4h 04m

$233

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 6/26

6:13 pm-5:04 pm

1 stop23h 51m

Lambert-St Louis

Sun 6/29

6:12 pm-10:38 am

1 stop15h 26m

$235

ColumbiaKansas City

CAE - MCI

CAEMCI

Columbia Metropolitan

Sun 6/8

2:32 pm-10:31 am

1 stop20h 59m

Kansas City

Fri 6/13

11:05 am-4:46 pm

1 stop28h 41m

$244

SavannahSpringfield

SAV - SGF

SAVSGF

Savannah/Hilton Head

Wed 7/23

2:43 pm-6:11 pm

1 stop4h 28m

Springfield-Branson

Sun 7/27

6:56 pm-11:59 pm

1 stop4h 03m

$249

ColumbiaKansas City

CAE - MCI

CAEMCI

Columbia Metropolitan

Mon 6/2

7:59 pm-11:59 pm

1 stop5h 00m

Kansas City

Sat 6/7

5:26 pm-11:58 pm

1 stop5h 32m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 59 results

...

Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Missouri as you normally would.

Rainfall in Missouri by month

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from South Carolina to Missouri to help guide your decision. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Southwest

8.0

Very good

4,294 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Delta

8.0

Very good

7,934 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

United Airlines

7.4

Good

8,696 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Spirit Airlines

6.3

Okay

7,963 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

How popular is this South Carolina to Missouri flight route?
The South Carolina to Missouri flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines to fly from South Carolina to Missouri one-way?
One-way options have recently been found by users for as low as $95 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $114 and American Airlines from $128 one-way.
Can I find deals for flights from South Carolina to Missouri that include hotel bookings?
Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Missouri?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.
Can I find deals for business class flights from South Carolina to Missouri?
Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from South Carolina to Missouri

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$139	Average$359	FlexibilityNo cancel fee	On-timeN/A
Spirit Airlines	Cheapest$149	Average$256	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$170	Average$384	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$174	Average$374	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$286	Average$389	FlexibilityNo cancel fee	On-time63%

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$95+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Missouri with Cheapflights

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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated May 1, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

Reviews of airlines servicing Missouri

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this South Carolina to Missouri flight route?

What are the cheapest airlines to fly from South Carolina to Missouri one-way?

Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

How can I find direct flights from South Carolina to Missouri?

Can I find deals for business class flights from South Carolina to Missouri?

What is the cheapest month to book a flight from South Carolina to Missouri?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from South Carolina to Missouri

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Travel Smart

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.