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$54+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Kiwi.com)

One-way from

$54
(Frontier)

Popular in

February

Cheapest in

August

Average price

$396
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
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From South Carolina to Missouri
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One-way flight from South Carolina to Missouri
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:11 pmCHS - STL
2 stops29h 50mMultiple Airlines
Thu 11/2710:53 amSTL - CHS
1 stop10h 12mMultiple Airlines
Deal found 10/11$196
This Trip.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/275:34 pmCLT - STL
1 stop16h 33mFrontier
Thu 10/308:40 pmSTL - CLT
1 stop19h 37mFrontier
Deal found 10/13$213
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:07 pmCLT - STL
1 stop16h 00mFrontier
Mon 11/177:45 pmSTL - CLT
2 stops20h 00mFrontier
Deal found 10/12$214
This Cheapflightsfares deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:00 amCLT - STL
1 stop8h 02mSpirit Airlines
Sun 12/72:57 pmSTL - CLT
1 stop6h 12mSpirit Airlines
Deal found 10/13$216
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/59:58 pmCLT - STL
Nonstop2h 09mAmerican Airlines
Wed 11/126:04 pmSTL - CLT
Nonstop1h 56mAmerican Airlines
Deal found 10/14$217
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:07 pmCLT - STL
1 stop16h 00mMultiple Airlines
Mon 11/1710:25 amSTL - CLT
1 stop9h 08mMultiple Airlines
Deal found 10/12$226
This Frontier deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3011:37 amCLT - STL
1 stop6h 50mFrontier
Sun 11/22:12 pmSTL - CLT
1 stop6h 28mFrontier
Deal found 10/12$227
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:20 amCAE - STL
1 stop6h 27mUnited Airlines
Sat 11/1510:00 amSTL - CAE
1 stop5h 43mUnited Airlines
Deal found 10/13$230
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/412:55 pmCLT - STL
Nonstop2h 10mSouthwest
Thu 11/64:15 pmSTL - CLT
Nonstop1h 45mSouthwest
Deal found 10/12$231
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:44 pmCLT - MCI
1 stop24h 44mMultiple Airlines
Mon 11/108:28 pmMCI - CLT
2 stops19h 20mMultiple Airlines
Deal found 10/11$231
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/42:27 pmCLT - STL
2 stops19h 40mMultiple Airlines
Thu 11/67:02 pmSTL - CLT
1 stop13h 00mMultiple Airlines
Deal found 10/12$232
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/119:05 pmCLT - MCI
1 stop16h 23mMultiple Airlines
Thu 11/136:00 amMCI - CLT
1 stop8h 55mMultiple Airlines
Deal found 10/13$232

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

South Carolina

Fly to

Missouri

Route

Depart

Return

Price

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 11/18

6:11 pm-11:01 pm

2 stops29h 50m

Lambert-St Louis

Thu 11/27

10:53 am-10:05 pm

1 stop10h 12m

$196

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Wed 3/25

6:50 pm-11:40 pm

1 stop5h 50m

Lambert-St Louis

Sat 3/28

10:00 am-4:29 pm

1 stop5h 29m

$217

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Wed 2/18

5:40 am-9:04 am

1 stop4h 24m

Lambert-St Louis

Sat 2/21

7:00 am-3:07 pm

1 stop7h 07m

$217

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 12/13

6:45 am-9:40 am

1 stop3h 55m

Lambert-St Louis

Thu 12/18

4:15 pm-7:00 pm

Nonstop1h 45m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 10/30

11:37 am-5:27 pm

1 stop6h 50m

Lambert-St Louis

Sun 11/2

2:12 pm-9:40 pm

1 stop6h 28m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 11/10

6:25 pm-7:35 pm

Nonstop2h 10m

Lambert-St Louis

Tue 11/11

1:50 pm-8:50 pm

1 stop6h 00m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 11/4

12:55 pm-2:05 pm

Nonstop2h 10m

Lambert-St Louis

Thu 11/6

5:45 pm-11:10 pm

1 stop4h 25m

$227

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Tue 11/11

10:20 am-3:47 pm

1 stop6h 27m

Lambert-St Louis

Sat 11/15

10:00 am-4:43 pm

1 stop5h 43m

$230

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Tue 11/11

9:05 pm-12:28 pm

1 stop16h 23m

Kansas City

Thu 11/13

6:00 am-3:55 pm

1 stop8h 55m

$232

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 11/27

2:15 pm-6:35 pm

1 stop5h 20m

Lambert-St Louis

Thu 12/4

7:05 am-1:27 pm

1 stop5h 22m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

It’s optimal to fly from South Carolina to Missouri in the evening. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from South Carolina to Missouri?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 14, 2025.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,975 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,042 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,096 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this South Carolina to Missouri flight route?

    The South Carolina to Missouri flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Missouri?

    A quick flight from South Carolina to Missouri can take about 3h 55m. Delta provides one of the quickest options available for as low as $227. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Missouri one-way?

    One-way options have recently been found by users for as low as $84 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $85 and Southwest from $109 one-way.

  • Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

    Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

  • Can I find deals for business class flights from South Carolina to Missouri?

    Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Missouri?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to Missouri

Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$139Average$372FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$199Average$250FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$204Average$387FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$236Average$411FlexibilityNo cancel feeOn-time63%

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