$99+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MCI
Aug 1 — Aug 81
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Sat 8/296:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Deal found 7/1![American Airlines logo]()
$197
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:56 pm
CLT
- STL
Nonstop2h 02m
American Airlines
Wed 8/56:54 am
STL
- CLT
Nonstop1h 56m
American Airlines
Deal found 7/1![American Airlines logo]()
$198
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Wed 7/293:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/30![Southwest logo]()
$199
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 8/41:40 pm
STL
- CLT
1 stop4h 20m
Southwest
Deal found 6/30![Southwest logo]()
$207
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:19 pm
CHS
- STL
1 stop6h 29m
Delta
Tue 10/136:00 am
STL
- CHS
1 stop5h 55m
Delta
Deal found 7/2![Delta logo]()
$209
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:08 pm
CHS
- STL
1 stop6h 20m
American Airlines
Wed 8/266:00 am
STL
- CHS
1 stop4h 33m
American Airlines
Deal found 6/27![American Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:45 am
CLT
- STL
2 stops8h 50m
Southwest
Tue 10/273:00 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/30![Southwest logo]()
$212
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:05 pm
CHS
- STL
1 stop7h 39m
American Airlines
Mon 9/145:00 am
STL
- CHS
1 stop7h 15m
American Airlines
Deal found 6/28![American Airlines logo]()
$213
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:50 am
CLT
- STL
1 stop3h 55m
Southwest
Wed 8/53:45 pm
STL
- CLT
1 stop4h 25m
Southwest
Deal found 7/1![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:30 am
CLT
- STL
2 stops9h 15m
Southwest
Wed 9/1610:45 am
STL
- CLT
2 stops9h 40m
Southwest
Deal found 7/1![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
CHS
- STL
1 stop7h 40m
Southwest
Thu 8/63:35 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/30![Southwest logo]()
$227
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
CHS
- STL
1 stop5h 14m
American Airlines
Thu 8/66:00 am
STL
- CHS
1 stop4h 33m
American Airlines
Deal found 6/30![American Airlines logo]()
$232
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:00 pm
CLT
- STL
1 stop4h 54m
Delta
Tue 9/226:00 am
STL
- CLT
1 stop6h 30m
Delta
Deal found 7/1![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:50 am
CLT
- STL
2 stops9h 00m
Southwest
Sat 9/2611:15 am
STL
- CLT
1 stop7h 05m
Southwest
Deal found 7/1![Southwest logo]()
$222
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
CLT
- STL
2 stops10h 46m
United Airlines
Tue 8/118:40 am
STL
- CLT
1 stop4h 38m
United Airlines
Deal found 6/27![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/128:44 pm
MYR
- STL
1 stop4h 13m
American Airlines
Tue 7/216:55 am
STL
- MYR
1 stop4h 31m
American Airlines
Deal found 6/27![American Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:30 am
CLT
- MCI
1 stop6h 47m
Delta
Sat 8/89:00 am
MCI
- CLT
1 stop5h 48m
Delta
Deal found 6/27![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:35 am
CLT
- STL
1 stop4h 35m
Southwest
Sat 12/125:50 am
STL
- CLT
2 stops10h 20m
Southwest
Deal found 7/1![Southwest logo]()
$246
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:05 am
CHS
- STL
1 stop3h 29m
Delta
Mon 9/147:05 am
STL
- CHS
1 stop5h 00m
Delta
Deal found 7/1![Delta logo]()
$255
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Fri 7/242:15 pm
STL
- CLT
1 stop5h 20m
Southwest
Deal found 7/1![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:10 pm
SAV
- MCI
2 stops8h 34m
United Airlines
Wed 8/267:30 am
MCI
- SAV
1 stop6h 34m
United Airlines
Deal found 6/29![United Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:40 pm
GSP
- STL
2 stops6h 25m
Southwest
Tue 9/81:40 pm
STL
- GSP
1 stop4h 45m
Southwest
Deal found 7/1![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Mon 8/101:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Deal found 6/28![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:43 am
SAV
- STL
1 stop4h 00m
Delta
Wed 7/226:58 pm
STL
- SAV
1 stop3h 55m
Delta
Deal found 6/29![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:50 am
CLT
- STL
2 stops9h 00m
Southwest
Fri 9/253:45 pm
STL
- CLT
1 stop5h 05m
Southwest
Deal found 7/1![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:43 pm
MYR
- STL
1 stop8h 15m
American Airlines
Wed 7/226:55 am
STL
- MYR
1 stop4h 27m
American Airlines
Deal found 6/27![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:59 pm
SAV
- STL
1 stop6h 01m
United Airlines
Wed 9/28:00 am
STL
- SAV
1 stop6h 04m
United Airlines
Deal found 6/28![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:56 pm
SAV
- MCI
2 stops7h 23m
American Airlines
Thu 8/66:00 am
MCI
- SAV
1 stop6h 31m
American Airlines
Deal found 6/27![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:30 pm
CLT
- STL
2 stops9h 10m
Southwest
Fri 8/288:30 am
STL
- CLT
2 stops8h 20m
Southwest
Deal found 7/1![Southwest logo]()
$280
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:49 am
GSP
- MCI
1 stop7h 04m
Delta
Wed 8/197:07 am
MCI
- GSP
1 stop5h 07m
Delta
Deal found 6/29![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:20 am
GSP
- STL
1 stop6h 53m
United Airlines
Wed 10/78:00 am
STL
- GSP
1 stop4h 35m
United Airlines
Deal found 7/1![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:41 pm
CHS
- MCI
1 stop7h 15m
American Airlines
Sun 9/205:03 am
MCI
- CHS
1 stop4h 36m
American Airlines
Deal found 6/27![American Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:28 pm
CHS
- STL
1 stop4h 47m
Delta
Thu 7/236:58 pm
STL
- CHS
1 stop4h 28m
Delta
Deal found 6/27![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:40 am
CLT
- STL
2 stops8h 40m
Southwest
Sun 8/96:00 am
STL
- CLT
2 stops9h 00m
Southwest
Deal found 6/27![Southwest logo]()
$304
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am
CHS
- STL
2 stops10h 53m
United Airlines
Mon 9/145:30 pm
STL
- CHS
1 stop4h 39m
United Airlines
Deal found 6/30![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:30 am
CLT
- STL
1 stop3h 49m
Delta
Fri 8/76:00 am
STL
- CLT
1 stop4h 03m
Delta
Deal found 6/29![Delta logo]()
$323
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:31 pm
SAV
- MCI
2 stops8h 14m
American Airlines
Thu 9/105:03 am
MCI
- SAV
1 stop4h 10m
American Airlines
Deal found 6/27![American Airlines logo]()
$411
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am
CHS
- STL
2 stops9h 38m
United Airlines
Wed 9/27:25 am
STL
- CHS
2 stops10h 45m
United Airlines
Deal found 7/1![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Thu 7/232:20 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/27![Southwest logo]()
$317
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:10 am
CLT
- MCI
1 stop6h 42m
Delta
Sun 8/1612:22 pm
MCI
- CLT
1 stop7h 03m
Delta
Deal found 6/27![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:41 pm
CAE
- STL
1 stop6h 48m
United Airlines
Tue 7/216:00 am
STL
- CAE
2 stops7h 16m
United Airlines
Deal found 6/28![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:35 am
CLT
- MCI
1 stop4h 05m
Southwest
Sat 8/16:50 am
MCI
- CLT
1 stop4h 35m
Southwest
Deal found 6/27![Southwest logo]()
$321
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated July 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated July 2, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:04 pm
CLT
- STL
1 stop22h 19m
Frontier
Fri 7/244:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Deal found 7/1![Frontier logo]()
$238
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:24 pm
CHS
- STL
1 stop5h 56m
Delta
Wed 7/296:58 pm
STL
- CHS
1 stop4h 28m
Delta
Deal found 6/30![Delta logo]()
$209
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Wed 7/293:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/30![Southwest logo]()
$199
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 8/41:40 pm
STL
- CLT
1 stop4h 20m
Southwest
Deal found 6/30![Southwest logo]()
$207
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:56 pm
CLT
- STL
Nonstop2h 02m
American Airlines
Wed 8/56:54 am
STL
- CLT
Nonstop1h 56m
American Airlines
Deal found 7/1![American Airlines logo]()
$198
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 am
CLT
- STL
1 stop5h 24m
Delta
Tue 8/115:23 pm
STL
- CLT
1 stop5h 34m
Delta
Deal found 7/1![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
CHS
- STL
1 stop7h 40m
Southwest
Thu 8/63:35 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/30![Southwest logo]()
$227
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
CHS
- STL
1 stop5h 14m
American Airlines
Thu 8/66:00 am
STL
- CHS
1 stop4h 33m
American Airlines
Deal found 6/30![American Airlines logo]()
$232
This CheapOair deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:04 pm
CLT
- STL
1 stop22h 19m
Frontier
Mon 8/104:09 pm
STL
- CLT
1 stop23h 29m
Frontier
Deal found 7/1![Frontier logo]()
$236
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:30 am
CLT
- MCI
1 stop6h 47m
Delta
Sat 8/89:00 am
MCI
- CLT
1 stop5h 48m
Delta
Deal found 6/27![Delta logo]()
$237
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:08 pm
CHS
- STL
1 stop6h 20m
American Airlines
Wed 8/266:00 am
STL
- CHS
1 stop4h 33m
American Airlines
Deal found 6/27![American Airlines logo]()
$211
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Sat 8/296:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Deal found 7/1![American Airlines logo]()
$197
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/30![Southwest logo]()
$99
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/30![Southwest logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:14 pm
SAV
- MCI
1 stop16h 32m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$103
This Frontier deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:47 am
CLT
- STL
1 stop6h 44m
Frontier
Deal found 6/30![Frontier logo]()
$105
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:20 am
CHS
- STL
1 stop5h 57m
Delta
Deal found 7/2![Delta logo]()
$105
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:20 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 6/29![Southwest logo]()
$107
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:39 pm
CLT
- STL
1 stop5h 36m
Delta
Deal found 7/1![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:30 pm
MYR
- STL
2 stops21h 52m
Frontier
Deal found 7/1![Frontier logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:19 pm
MYR
- STL
2 stops38h 21m
Frontier
Deal found 7/1![Frontier logo]()
$110
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:54 pm
CHS
- STL
2 stops9h 05m
United Airlines
Deal found 6/29![United Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am
CHS
- STL
2 stops28h 40m
Multiple Airlines
Deal found 7/1![Multiple Airlines logo]()
$113
This CheapOair deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/29![Frontier logo]()
$116
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated July 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (American Airlines) |
One-way from | $99 (Southwest) |
Popular in | December |
Cheapest in | August |
Average price | $467 |
Good round-trip deal | $336 or less |
Good one-way deal | $203 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 9/16
12:00 pm-3:54 pm
1 stop4h 54m
Lambert-St Louis
Tue 9/22
6:00 am-1:30 pm
1 stop6h 30m
$217
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 9/23
6:50 am-2:50 pm
2 stops9h 00m
Lambert-St Louis
Sat 9/26
11:15 am-7:20 pm
1 stop7h 05m
$222
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Wed 8/5
5:30 am-11:17 am
1 stop6h 47m
Kansas City
Sat 8/8
9:00 am-3:48 pm
1 stop5h 48m
$237
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Mon 8/17
6:35 am-10:10 am
1 stop4h 35m
Lambert-St Louis
Sat 12/12
5:50 am-5:10 pm
2 stops10h 20m
$246
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 9/10
7:05 am-9:34 am
1 stop3h 29m
Lambert-St Louis
Mon 9/14
7:05 am-1:05 pm
1 stop5h 00m
$255
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 7/22
1:25 pm-2:25 pm
Nonstop2h 00m
Lambert-St Louis
Fri 7/24
2:15 pm-8:35 pm
1 stop5h 20m
$273
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 9/3
4:40 pm-10:05 pm
2 stops6h 25m
Lambert-St Louis
Tue 9/8
1:40 pm-7:25 pm
1 stop4h 45m
$274
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 9/23
6:50 am-2:50 pm
2 stops9h 00m
Lambert-St Louis
Fri 9/25
3:45 pm-9:50 pm
1 stop5h 05m
$275
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Tue 8/25
1:30 pm-9:40 pm
2 stops9h 10m
Lambert-St Louis
Fri 8/28
8:30 am-5:50 pm
2 stops8h 20m
$280
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Wed 7/22
6:43 am-9:43 am
1 stop4h 00m
Lambert-St Louis
Wed 7/22
6:58 pm-11:53 pm
1 stop3h 55m
$297
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CLT-STL
MYR-STL
CLT-MCI
CHS-STL
SAV-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CLT-STL
MYR-STL
CLT-MCI
CHS-STL
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $154). Flying from South Carolina to Missouri in March is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2026.
It’s optimal to fly from South Carolina to Missouri in the evening. By choosing this option you can save up to 21% on the cost of your flight, compared to a flight at noon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 2, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Overall
7.9
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Overall
7.9
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Overall
7.9
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Overall
7.9
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Overall
7.9
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on July 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$177 | Average$407 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$206 | Average$419 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$413 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$403 | FlexibilityNo cancel fee | On-time69% |