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Missouri

$62+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated septiembre 11, 2025.

Round-trip from

$196
(Southwest)

One-way from

$62
(Southwest)

Popular in

June

Cheapest in

February

Average price

$325

Good round-trip deal

$318 or less

Good one-way deal

$178 or less
From South Carolina to Missouri
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One-way flight from South Carolina to Missouri
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Highest demand for flights based on searches. 12% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from South Carolina to Missouri.
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Price to beat on a one-way flight from South Carolina to Missouri.
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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/295:25 pmCLT - MCI
1 stop5h 50mSouthwest
mié. 12/171:30 pmMCI - CLT
1 stop6h 40mSouthwest
Deal found 9/9$187
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/311:20 pmCLT - MCI
2 stops46h 57mMultiple Airlines
dom. 12/144:35 pmMCI - CLT
1 stop19h 46mMultiple Airlines
Deal found 9/9$195
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/127:00 amCLT - MCI
1 stop5h 55mSouthwest
sáb. 11/1511:25 amMCI - CLT
1 stop6h 45mSouthwest
Deal found 9/10$200
This Cheapflightsfares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/69:49 amCLT - MCI
1 stop8h 14mSpirit Airlines
sáb. 12/136:08 pmMCI - CLT
1 stop5h 51mSpirit Airlines
Deal found 9/9$203
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/316:07 pmCLT - MCI
1 stop26h 31mMultiple Airlines
lun. 12/1511:51 amMCI - CLT
2 stops19h 46mMultiple Airlines
Deal found 9/9$205
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:45 pmSAV - MCI
1 stop5h 40mSouthwest
sáb. 11/16:25 amMCI - SAV
1 stop7h 25mSouthwest
Deal found 9/10$206
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/41:36 pmCLT - MCI
1 stop8h 11mAmerican Airlines
mié. 10/86:00 amMCI - CLT
1 stop9h 00mAmerican Airlines
Deal found 9/11$207
This Cheapflightsfares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/610:11 pmCLT - MCI
1 stop11h 53mSpirit Airlines
lun. 11/1012:13 pmMCI - CLT
1 stop11h 46mSpirit Airlines
Deal found 9/9$210
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/17:59 pmCLT - MCI
2 stops16h 18mMultiple Airlines
dom. 12/144:35 pmMCI - CLT
1 stop19h 46mMultiple Airlines
Deal found 9/9$212
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/111:06 amCHS - STL
1 stop6h 01mUnited Airlines
sáb. 10/48:00 amSTL - CHS
1 stop5h 07mUnited Airlines
Deal found 9/10$213
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/136:05 amSAV - MCI
1 stop4h 30mSouthwest
dom. 11/167:15 amMCI - SAV
1 stop4h 20mSouthwest
Deal found 9/11$216
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/292:40 pmCLT - MCI
1 stop7h 05mMultiple Airlines
dom. 12/144:35 pmMCI - CLT
1 stop19h 46mMultiple Airlines
Deal found 9/9$217

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

South Carolina

Fly to

Missouri

Route

Depart

Return

Price

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mié. 10/1

11:06 am-4:07 pm

1 stop6h 01m

Lambert-St Louis

sáb. 10/4

8:00 am-2:07 pm

1 stop5h 07m

$213

SavannahKansas City

SAV - MCI

SAVMCI

Savannah/Hilton Head

jue. 11/13

6:05 am-9:35 am

1 stop4h 30m

Kansas City

dom. 11/16

7:15 am-12:35 pm

1 stop4h 20m

$216

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/18

4:00 pm-8:57 pm

1 stop5h 57m

Lambert-St Louis

sáb. 2/21

10:00 am-2:11 pm

1 stop3h 11m

$217

CharlestonKansas City

CHS - MCI

CHSMCI

Charleston

vie. 10/24

10:11 am-4:16 pm

1 stop7h 05m

Kansas City

lun. 10/27

11:37 am-6:41 pm

2 stops30h 04m

$218

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mar. 9/30

7:10 am-1:20 pm

1 stop7h 10m

Lambert-St Louis

mar. 10/7

6:00 am-1:25 pm

1 stop6h 25m

$221

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mar. 10/14

7:05 pm-10:04 pm

1 stop3h 59m

Lambert-St Louis

mar. 10/21

1:35 pm-9:03 pm

1 stop6h 28m

$221

SavannahKansas City

SAV - MCI

SAVMCI

Savannah/Hilton Head

mié. 10/8

7:10 am-4:16 pm

2 stops10h 06m

Kansas City

mié. 10/15

3:23 pm-9:47 pm

1 stop5h 24m

$224

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

mar. 11/25

6:00 am-9:46 am

1 stop4h 46m

Lambert-St Louis

jue. 11/27

6:40 am-2:50 pm

1 stop7h 10m

$224

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mar. 9/30

2:59 pm-8:32 pm

2 stops6h 33m

Lambert-St Louis

mar. 10/7

7:00 am-1:36 pm

1 stop5h 36m

$226

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

jue. 10/9

8:03 pm-11:41 pm

1 stop4h 38m

Lambert-St Louis

mar. 10/14

1:30 pm-8:51 pm

1 stop6h 21m

$226

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated septiembre 11, 2025.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,023 reviews
Southwest
8.0
Very good
4,248 reviews

Crew

8.6

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this South Carolina to Missouri flight route?

    The South Carolina to Missouri flight path was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Missouri?

    A quick flight from South Carolina to Missouri can take about 4h 30m. United Airlines provides one of the quickest options available for as low as $216. Airlines will cover a distance of 903 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Missouri one-way?

    One-way options have recently been found by users for as low as $62 on Southwest. Other airlines that offer cheap prices include Delta from $103 and United Airlines from $114 one-way.

  • Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

    Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

  • Can I find deals for business class flights from South Carolina to Missouri?

    Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Missouri?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to Missouri

Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$139Average$353FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$199Average$246FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$204Average$384FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$226Average$393FlexibilityNo cancel feeOn-time63%

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