$90+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Jun 5 — Jun 121
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Missouri with Cheapflights
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Sat 5/236:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 5/1![Frontier logo]()
$160
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:12 pm
CLT
- STL
1 stop11h 45m
Frontier
Mon 6/811:38 am
STL
- CLT
1 stop22h 56m
Frontier
Deal found 5/4![Frontier logo]()
$181
This Frontier deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:08 pm
CLT
- STL
1 stop8h 23m
Frontier
Sat 5/306:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 5/2![Frontier logo]()
$185
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:20 pm
CLT
- STL
1 stop28h 14m
Frontier
Fri 6/54:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 5/1![Frontier logo]()
$191
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:45 pm
CLT
- STL
Nonstop1h 59m
American Airlines
Wed 6/176:13 pm
STL
- CLT
Nonstop2h 02m
American Airlines
Deal found 5/3![American Airlines logo]()
$197
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:00 pm
CLT
- STL
1 stop11h 57m
Frontier
Tue 6/94:17 pm
STL
- CLT
1 stop18h 17m
Frontier
Deal found 5/5![Frontier logo]()
$200
This CheapOair deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:14 pm
CLT
- STL
1 stop21h 39m
Frontier
Wed 6/174:17 pm
STL
- CLT
1 stop18h 17m
Frontier
Deal found 5/2![Frontier logo]()
$201
This CheapOair deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:14 pm
CLT
- MCI
1 stop15h 41m
Frontier
Wed 7/291:45 pm
MCI
- CLT
1 stop6h 38m
Frontier
Deal found 5/3![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:16 pm
CLT
- STL
2 stops25h 59m
Multiple Airlines
Tue 6/24:19 pm
STL
- CLT
1 stop24h 25m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$203
This Expedia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:20 pm
CLT
- STL
1 stop28h 14m
Frontier
Sun 5/319:06 pm
STL
- CLT
1 stop8h 53m
Frontier
Deal found 4/30![Frontier logo]()
$205
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:35 am
CLT
- STL
1 stop4h 55m
Southwest
Wed 6/104:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 5/3![Southwest logo]()
$207
This Frontier deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:58 pm
CLT
- STL
1 stop5h 16m
Frontier
Tue 9/16:58 pm
STL
- CLT
1 stop11h 17m
Frontier
Deal found 5/2![Frontier logo]()
$210
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:28 pm
GSP
- STL
1 stop28h 29m
Multiple Airlines
Sun 6/76:33 pm
STL
- GSP
2 stops16h 59m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:50 pm
GSP
- STL
1 stop4h 10m
Southwest
Wed 6/101:45 pm
STL
- GSP
1 stop4h 15m
Southwest
Deal found 5/5![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:35 am
CLT
- STL
1 stop3h 43m
Delta
Mon 6/87:12 pm
STL
- CLT
1 stop3h 47m
Delta
Deal found 5/4![Delta logo]()
$278
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:55 am
CHS
- STL
1 stop7h 43m
United Airlines
Wed 8/197:30 am
STL
- CHS
1 stop5h 25m
United Airlines
Deal found 5/2![United Airlines logo]()
$307
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:00 am
CHS
- STL
1 stop5h 10m
Southwest
Tue 6/233:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 5/2![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:10 pm
CLT
- STL
2 stops8h 40m
Southwest
Sat 6/275:40 am
STL
- CLT
1 stop4h 15m
Southwest
Deal found 5/3![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:52 am
GSP
- STL
1 stop4h 42m
Delta
Mon 6/227:12 pm
STL
- GSP
1 stop3h 47m
Delta
Deal found 5/1![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Wed 6/106:00 am
STL
- CLT
1 stop8h 09m
United Airlines
Deal found 5/5![United Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:00 pm
CLT
- STL
1 stop11h 57m
Multiple Airlines
Mon 5/255:27 pm
STL
- CLT
2 stops19h 44m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:05 pm
SAV
- STL
1 stop3h 55m
Southwest
Wed 6/109:40 am
STL
- SAV
2 stops7h 05m
Southwest
Deal found 5/4![Southwest logo]()
$296
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:30 am
GSP
- STL
1 stop6h 43m
United Airlines
Wed 8/195:00 am
STL
- GSP
1 stop7h 38m
United Airlines
Deal found 5/3![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/29:42 am
CLT
- STL
1 stop3h 52m
Delta
Sun 7/56:00 am
STL
- CLT
1 stop4h 32m
Delta
Deal found 5/5![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:00 am
GSP
- STL
2 stops6h 35m
Southwest
Mon 6/12:10 pm
STL
- GSP
1 stop7h 25m
Southwest
Deal found 5/2![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:40 am
GSP
- STL
1 stop3h 38m
Delta
Sun 6/76:00 am
STL
- GSP
1 stop3h 59m
Delta
Deal found 5/2![Delta logo]()
$336
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:43 pm
CHS
- STL
1 stop5h 17m
United Airlines
Sat 8/296:00 am
STL
- CHS
1 stop6h 55m
United Airlines
Deal found 5/1![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Mon 7/132:30 pm
STL
- CLT
1 stop3h 40m
Southwest
Deal found 5/1![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:36 am
SAV
- STL
1 stop6h 49m
Delta
Sat 5/307:05 pm
STL
- SAV
1 stop3h 35m
Delta
Deal found 5/5![Delta logo]()
$341
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2611:30 am
SAV
- STL
1 stop5h 16m
United Airlines
Thu 7/28:00 am
STL
- SAV
1 stop5h 16m
United Airlines
Deal found 5/2![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:08 pm
SAV
- STL
1 stop4h 45m
Delta
Mon 7/2710:51 am
STL
- SAV
1 stop4h 23m
Delta
Deal found 5/3![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:15 am
CLT
- STL
1 stop8h 00m
Southwest
Mon 5/2510:15 am
STL
- CLT
2 stops7h 30m
Southwest
Deal found 4/30![Southwest logo]()
$315
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Sat 6/271:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Deal found 5/4![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:30 am
CLT
- STL
1 stop6h 25m
Southwest
Fri 6/53:40 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 5/1![Southwest logo]()
$320
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:14 pm
SAV
- STL
1 stop7h 08m
United Airlines
Wed 8/196:00 am
STL
- SAV
1 stop7h 11m
United Airlines
Deal found 5/5![United Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:55 pm
MYR
- MCI
1 stop4h 54m
Delta
Mon 6/16:38 pm
MCI
- MYR
1 stop4h 20m
Delta
Deal found 5/1![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:25 am
GSP
- MCI
1 stop4h 10m
Southwest
Sat 6/66:50 am
MCI
- GSP
1 stop4h 25m
Southwest
Deal found 5/2![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
GSP
- MCI
2 stops9h 52m
United Airlines
Wed 8/196:00 am
MCI
- GSP
1 stop6h 38m
United Airlines
Deal found 5/1![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/177:00 am
GSP
- STL
2 stops8h 50m
Southwest
Mon 6/225:35 pm
STL
- GSP
1 stop4h 15m
Southwest
Deal found 5/1![Southwest logo]()
$322
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:30 am
GSP
- MCI
2 stops11h 11m
United Airlines
Tue 9/293:22 pm
MCI
- GSP
1 stop4h 49m
United Airlines
Deal found 5/1![United Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:35 am
CLT
- MCI
1 stop4h 54m
Delta
Mon 6/15:13 pm
MCI
- CLT
1 stop5h 40m
Delta
Deal found 5/4![Delta logo]()
$414
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:40 pm
CHS
- STL
1 stop4h 45m
Southwest
Wed 6/103:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 5/5![Southwest logo]()
$323
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated May 6, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated May 6, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Sat 5/236:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 5/4![Frontier logo]()
$206
This Frontier deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:08 pm
CLT
- STL
1 stop8h 23m
Frontier
Sat 5/306:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 5/2![Frontier logo]()
$185
This Priceline deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:08 pm
CLT
- STL
1 stop8h 23m
Frontier
Wed 5/276:51 pm
STL
- CLT
1 stop11h 08m
Frontier
Deal found 5/4![Frontier logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:34 pm
CHS
- STL
1 stop8h 23m
Multiple Airlines
Fri 5/294:19 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$236
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:20 pm
CLT
- STL
1 stop28h 14m
Frontier
Fri 6/54:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 5/1![Frontier logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:41 pm
CLT
- STL
2 stops23h 52m
Frontier
Mon 6/84:19 pm
STL
- CLT
1 stop18h 15m
Frontier
Deal found 5/2![Frontier logo]()
$211
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:00 pm
CLT
- STL
1 stop11h 57m
Frontier
Tue 6/94:17 pm
STL
- CLT
1 stop18h 17m
Frontier
Deal found 5/5![Frontier logo]()
$200
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:45 pm
CLT
- STL
Nonstop1h 59m
American Airlines
Wed 6/105:14 am
STL
- CLT
Nonstop1h 54m
American Airlines
Deal found 5/3![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:35 am
CLT
- STL
1 stop4h 55m
Southwest
Wed 6/104:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 5/3![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:40 am
CLT
- STL
2 stops7h 20m
Southwest
Wed 6/174:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 5/3![Southwest logo]()
$212
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:12 pm
CLT
- STL
1 stop11h 45m
Frontier
Mon 6/811:38 am
STL
- CLT
1 stop22h 56m
Frontier
Deal found 5/4![Frontier logo]()
$181
This CheapOair deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:14 pm
CLT
- STL
1 stop21h 39m
Frontier
Wed 6/174:17 pm
STL
- CLT
1 stop18h 17m
Frontier
Deal found 5/2![Frontier logo]()
$201
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
This Priceline deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:55 am
CLT
- STL
1 stop10h 11m
Frontier
Deal found 5/1![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:55 am
CLT
- STL
1 stop9h 39m
Frontier
Deal found 5/1![Frontier logo]()
$95
This Expedia deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:14 pm
CLT
- STL
1 stop25h 09m
Frontier
Deal found 5/3![Frontier logo]()
$96
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:00 pm
CLT
- STL
1 stop11h 57m
Frontier
Deal found 5/6![Frontier logo]()
$101
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:14 pm
CLT
- MCI
1 stop15h 41m
Frontier
Deal found 5/5![Frontier logo]()
$106
This CheapOair deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2812:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Deal found 5/2![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:26 pm
CLT
- MCI
2 stops24h 55m
Frontier
Deal found 5/5![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:58 pm
CLT
- STL
1 stop28h 59m
Frontier
Deal found 5/1![Frontier logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:43 pm
GSP
- MCI
2 stops44h 38m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$108
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:35 am
CLT
- STL
1 stop3h 43m
Delta
Deal found 5/1![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/301:52 pm
SAV
- STL
2 stops20h 05m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:26 pm
CLT
- MCI
2 stops24h 55m
Frontier
Deal found 5/5![Frontier logo]()
$109
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated May 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $160 (Frontier) |
One-way from | $90 (Priceline) |
Popular in | December |
Cheapest in | August |
Average price | $416 |
Good round-trip deal | $381 or less |
Good one-way deal | $175 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Mon 6/1
8:28 pm-11:57 pm
1 stop28h 29m
Lambert-St Louis
Sun 6/7
6:33 pm-12:32 pm
2 stops16h 59m
$245
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 6/9
7:50 pm-11:00 pm
1 stop4h 10m
Lambert-St Louis
Wed 6/10
1:45 pm-7:00 pm
1 stop4h 15m
$267
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 6/18
8:00 am-12:10 pm
1 stop5h 10m
Lambert-St Louis
Tue 6/23
3:15 pm-6:15 pm
Nonstop2h 00m
$277
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 6/5
5:35 am-8:18 am
1 stop3h 43m
Lambert-St Louis
Mon 6/8
7:12 pm-11:59 pm
1 stop3h 47m
$278
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 6/26
1:10 pm-8:50 pm
2 stops8h 40m
Lambert-St Louis
Sat 6/27
5:40 am-10:55 am
1 stop4h 15m
$288
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Wed 6/3
7:05 pm-10:00 pm
1 stop3h 55m
Lambert-St Louis
Wed 6/10
9:40 am-5:45 pm
2 stops7h 05m
$296
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 5/30
8:00 am-1:35 pm
2 stops6h 35m
Lambert-St Louis
Mon 6/1
2:10 pm-10:35 pm
1 stop7h 25m
$302
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 8/18
8:55 am-3:38 pm
1 stop7h 43m
Lambert-St Louis
Wed 8/19
7:30 am-1:55 pm
1 stop5h 25m
$307
Quickest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 7/8
1:25 pm-2:25 pm
Nonstop2h 00m
Lambert-St Louis
Mon 7/13
2:30 pm-7:10 pm
1 stop3h 40m
$309
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 5/21
6:15 am-1:15 pm
1 stop8h 00m
Lambert-St Louis
Mon 5/25
10:15 am-6:45 pm
2 stops7h 30m
$315
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
GSP-MCI
CHS-STL
CLT-STL
CLT-MCI
SAV-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
GSP-MCI
CHS-STL
CLT-STL
CLT-MCI
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in March is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 6, 2026.
It’s optimal to fly from South Carolina to Missouri in the afternoon. By choosing this option you can save up to 43% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from South Carolina to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 6, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on May 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$177 | Average$404 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$226 | Average$421 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$353 | FlexibilityNo cancel fee | On-time69% |