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Missouri

$47+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$119
(Mytrip)

One-way from

$47
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$324
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
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From South Carolina to Missouri
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One-way flight from South Carolina to Missouri
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:45 amCLT - STL
1 stop12h 48mFrontier
Tue 12/163:30 pmSTL - CLT
1 stop17h 20mFrontier
Deal found 11/4$119
This CheapOair deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:20 pmCLT - STL
1 stop26h 13mFrontier
Thu 12/113:30 pmSTL - CLT
1 stop5h 08mFrontier
Deal found 11/3$120
This Booking.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/310:45 amCLT - STL
1 stop12h 48mFrontier
Wed 12/103:30 pmSTL - CLT
1 stop21h 11mFrontier
Deal found 11/5$121
This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:33 pmCLT - STL
1 stop11h 26mFrontier
Fri 12/53:30 pmSTL - CLT
1 stop5h 08mFrontier
Deal found 11/6$124
This Frontier deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:33 pmCLT - STL
1 stop11h 26mFrontier
Mon 12/89:54 amSTL - CLT
1 stop9h 31mFrontier
Deal found 11/5$128
This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/68:52 amCLT - STL
1 stop14h 41mFrontier
Mon 12/89:54 amSTL - CLT
1 stop9h 31mFrontier
Deal found 11/6$129
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/210:45 amCLT - STL
1 stop12h 48mFrontier
Tue 12/93:30 pmSTL - CLT
1 stop17h 20mFrontier
Deal found 11/4$133
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/182:27 pmCLT - STL
1 stop20h 38mFrontier
Fri 11/214:13 pmSTL - CLT
1 stop20h 13mFrontier
Deal found 11/4$136
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:33 pmCLT - STL
1 stop11h 26mFrontier
Sun 12/149:54 amSTL - CLT
1 stop22h 43mFrontier
Deal found 11/4$137
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/182:27 pmCLT - STL
1 stop20h 38mFrontier
Sat 11/224:13 pmSTL - CLT
1 stop14h 46mFrontier
Deal found 11/4$138
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/251:54 pmCLT - STL
1 stop20h 35mFrontier
Thu 11/274:13 pmSTL - CLT
1 stop15h 26mFrontier
Deal found 11/4$148
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1210:33 pmCLT - STL
1 stop25h 00mFrontier
Sun 12/149:54 amSTL - CLT
1 stop22h 43mFrontier
Deal found 11/4$154

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

South Carolina

Fly to

Missouri

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 12/8

9:20 pm-10:33 pm

1 stop26h 13m

Lambert-St Louis

Thu 12/11

3:30 pm-9:38 pm

1 stop5h 08m

$120

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 12/11

12:55 pm-2:05 pm

Nonstop2h 10m

Lambert-St Louis

Sun 12/14

4:15 pm-7:00 pm

Nonstop1h 45m

$181

CharlestonKansas City

CHS - MCI

CHSMCI

Charleston

Thu 1/22

6:31 pm-10:31 am

1 stop17h 00m

Kansas City

Mon 1/26

4:28 pm-8:38 am

1 stop15h 10m

$202

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Wed 2/18

7:00 am-12:25 pm

1 stop6h 25m

Lambert-St Louis

Sat 2/21

10:13 am-4:22 pm

1 stop5h 09m

$211

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 12/12

6:25 pm-7:35 pm

Nonstop2h 10m

Lambert-St Louis

Wed 12/17

2:55 pm-5:40 pm

Nonstop1h 45m

$211

CharlestonKansas City

CHS - MCI

CHSMCI

Charleston

Fri 12/12

9:49 pm-5:56 pm

1 stop21h 07m

Kansas City

Mon 12/15

3:47 pm-8:37 am

1 stop15h 50m

$211

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Thu 12/4

7:00 am-1:52 pm

1 stop7h 52m

Lambert-St Louis

Sun 12/7

2:47 pm-11:18 pm

1 stop7h 31m

$229

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Tue 11/25

10:11 am-4:07 pm

1 stop6h 56m

Lambert-St Louis

Thu 11/27

6:00 am-12:06 pm

1 stop5h 06m

$230

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sun 12/7

5:50 am-10:25 am

1 stop5h 35m

Lambert-St Louis

Tue 12/9

2:55 pm-5:40 pm

Nonstop1h 45m

$232

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 12/12

6:25 pm-7:35 pm

Nonstop2h 10m

Lambert-St Louis

Mon 12/15

2:55 pm-5:40 pm

Nonstop1h 45m

$233

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from South Carolina to Missouri in the evening. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from South Carolina to Missouri?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 6, 2025.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,122 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this South Carolina to Missouri flight route?

    The South Carolina to Missouri flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Missouri?

    A quick flight from South Carolina to Missouri can take about 2h 10m. Frontier provides one of the quickest options available for as low as $181. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Missouri one-way?

    One-way options have recently been found by users for as low as $69 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $98 and United Airlines from $99 one-way.

  • Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

    Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

  • Can I find deals for business class flights from South Carolina to Missouri?

    Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Missouri?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to Missouri

Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$139Average$370FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$199Average$250FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$204Average$384FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$236Average$414FlexibilityNo cancel feeOn-time63%

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