$64+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Mar 1 — Mar 81
1 adult, Economy
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Find cheap flights from South Carolina to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Missouri
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:28 am
CLT
- STL
1 stop15h 31m
Frontier
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 1/29![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Mon 3/94:51 pm
STL
- CLT
1 stop14h 12m
Frontier
Deal found 1/28![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Wed 3/45:18 pm
STL
- CLT
1 stop22h 00m
Frontier
Deal found 1/28![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:49 pm
CLT
- STL
1 stop7h 38m
Multiple Airlines
Tue 2/243:49 pm
STL
- CLT
1 stop21h 02m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:21 am
CLT
- STL
2 stops22h 30m
Multiple Airlines
Fri 2/273:49 pm
STL
- CLT
1 stop15h 44m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$163
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Wed 3/45:18 pm
STL
- CLT
1 stop22h 00m
Frontier
Deal found 1/28![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/214:49 pm
CLT
- STL
1 stop8h 10m
Frontier
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 1/27![Frontier logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Mon 3/28:22 pm
STL
- CLT
2 stops16h 29m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$168
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:24 pm
CLT
- MCI
1 stop22h 06m
Spirit Airlines
Sun 2/2211:26 am
MCI
- CLT
1 stop20h 00m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Multiple Airlines
Wed 3/48:17 pm
STL
- CLT
2 stops20h 33m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:00 am
CLT
- MCI
1 stop24h 30m
Multiple Airlines
Wed 3/44:39 pm
MCI
- CLT
1 stop22h 39m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:49 pm
CLT
- STL
1 stop7h 38m
Multiple Airlines
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$173
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 30, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:28 am
CLT
- STL
1 stop15h 31m
Frontier
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 1/29![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Mon 3/28:22 pm
STL
- CLT
2 stops16h 29m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$168
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:13 pm
CLT
- MCI
1 stop16h 17m
Spirit Airlines
Thu 3/511:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$210
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:25 am
CLT
- STL
Nonstop2h 10m
Southwest
Sat 2/283:05 pm
STL
- CLT
Nonstop1h 45m
Southwest
Deal found 1/27![Southwest logo]()
$231
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:35 am
CAE
- STL
1 stop4h 31m
Delta
Sun 2/226:56 pm
STL
- CAE
1 stop3h 51m
Delta
Deal found 1/28![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:03 pm
CHS
- STL
1 stop5h 05m
United Airlines
Sat 5/97:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Deal found 1/29![United Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:51 pm
SAV
- MCI
2 stops8h 09m
American Airlines
Wed 2/2512:36 pm
MCI
- SAV
2 stops7h 47m
American Airlines
Deal found 1/29![American Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2310:42 pm
CLT
- MCI
1 stop17h 47m
Multiple Airlines
Sun 3/111:26 am
MCI
- CLT
1 stop20h 00m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$188
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Thu 3/53:49 pm
STL
- CLT
1 stop24h 16m
Frontier
Deal found 1/29![Frontier logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/203:21 pm
CHS
- STL
1 stop10h 06m
Multiple Airlines
Mon 2/233:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Deal found 1/27![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
CHS
- MCI
1 stop29h 07m
Spirit Airlines
Sat 4/2512:12 pm
MCI
- CHS
1 stop9h 29m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Thu 2/2610:11 pm
STL
- CLT
2 stops17h 07m
Frontier
Deal found 1/28![Frontier logo]()
$207
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/211:10 pm
CLT
- STL
Nonstop2h 15m
Southwest
Mon 2/232:55 pm
STL
- CLT
Nonstop1h 45m
Southwest
Deal found 1/27![Southwest logo]()
$240
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:10 pm
CLT
- STL
Nonstop2h 15m
Southwest
Mon 3/22:55 pm
STL
- CLT
Nonstop1h 45m
Southwest
Deal found 1/29![Southwest logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:12 pm
CLT
- MCI
2 stops19h 44m
Multiple Airlines
Tue 3/34:24 pm
MCI
- CLT
1 stop16h 53m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$226
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:35 am
CAE
- STL
1 stop4h 18m
Delta
Fri 2/206:47 pm
STL
- CAE
1 stop4h 00m
Delta
Deal found 1/28![Delta logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/19:52 pm
CLT
- MCI
2 stops13h 01m
Frontier
Wed 3/44:39 pm
MCI
- CLT
1 stop22h 39m
Frontier
Deal found 1/30![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:01 pm
CLT
- MCI
1 stop22h 28m
Spirit Airlines
Fri 2/1311:26 am
MCI
- CLT
1 stop20h 00m
Spirit Airlines
Deal found 1/28![Spirit Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
CHS
- STL
1 stop5h 58m
United Airlines
Tue 3/39:55 am
STL
- CHS
2 stops8h 05m
United Airlines
Deal found 1/29![United Airlines logo]()
$301
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:35 am
CAE
- STL
1 stop4h 31m
Delta
Thu 2/196:30 am
STL
- CAE
1 stop8h 10m
Delta
Deal found 1/28![Delta logo]()
$274
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:25 am
CLT
- STL
Nonstop2h 10m
Southwest
Thu 2/263:10 pm
STL
- CLT
1 stop6h 20m
Southwest
Deal found 1/28![Southwest logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:20 pm
CLT
- MCI
2 stops25h 26m
Multiple Airlines
Mon 3/211:26 am
MCI
- CLT
1 stop11h 30m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$230
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:55 am
CLT
- MCI
1 stop27h 12m
Spirit Airlines
Mon 5/1112:12 pm
MCI
- CLT
1 stop19h 14m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$270
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:35 am
CAE
- STL
1 stop4h 31m
Delta
Wed 2/181:13 pm
STL
- CAE
1 stop6h 04m
Delta
Deal found 1/28![Delta logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:00 am
CLT
- MCI
1 stop24h 30m
Multiple Airlines
Sun 3/88:40 pm
MCI
- CLT
2 stops11h 36m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$232
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:26 pm
GSP
- MCI
1 stop7h 23m
American Airlines
Mon 3/95:00 am
MCI
- GSP
1 stop4h 56m
American Airlines
Deal found 1/28![American Airlines logo]()
$340
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:40 am
SAV
- MCI
1 stop5h 44m
United Airlines
Wed 2/2510:24 am
MCI
- SAV
2 stops7h 59m
United Airlines
Deal found 1/29![United Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:35 am
CAE
- STL
1 stop4h 18m
Delta
Thu 2/196:30 am
STL
- CAE
1 stop8h 10m
Delta
Deal found 1/28![Delta logo]()
$274
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:15 am
CHS
- STL
1 stop5h 15m
Southwest
Sat 5/95:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 1/29![Southwest logo]()
$286
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:35 pm
CHS
- MCI
1 stop15h 55m
Spirit Airlines
Wed 3/114:24 pm
MCI
- CHS
3 stops28h 49m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$287
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated January 30, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated January 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:01 pm
CLT
- STL
1 stop6h 32m
Multiple Airlines
Mon 2/95:42 pm
STL
- CLT
1 stop19h 09m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$174
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:24 pm
CLT
- MCI
1 stop22h 06m
Spirit Airlines
Sun 2/2211:26 am
MCI
- CLT
1 stop20h 00m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:49 pm
CLT
- STL
1 stop7h 38m
Multiple Airlines
Tue 2/243:49 pm
STL
- CLT
1 stop21h 02m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/214:49 pm
CLT
- STL
1 stop8h 10m
Frontier
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 1/27![Frontier logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:21 am
CLT
- STL
2 stops22h 30m
Multiple Airlines
Fri 2/273:49 pm
STL
- CLT
1 stop15h 44m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Wed 3/45:18 pm
STL
- CLT
1 stop22h 00m
Frontier
Deal found 1/28![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Multiple Airlines
Wed 3/48:17 pm
STL
- CLT
2 stops20h 33m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:00 am
CLT
- MCI
1 stop24h 30m
Multiple Airlines
Wed 3/44:39 pm
MCI
- CLT
1 stop22h 39m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:00 am
CLT
- MCI
1 stop24h 30m
Multiple Airlines
Mon 3/211:26 am
MCI
- CLT
1 stop20h 00m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:49 pm
CLT
- STL
1 stop7h 38m
Multiple Airlines
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:28 am
CLT
- STL
1 stop15h 31m
Frontier
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 1/29![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Mon 3/28:22 pm
STL
- CLT
2 stops16h 29m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$168
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated January 30, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated January 30, 2026.
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/29![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:42 pm
CLT
- STL
1 stop24h 45m
Frontier
Deal found 1/28![Frontier logo]()
$67
This Trip.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:38 pm
CLT
- STL
1 stop8h 21m
Frontier
Deal found 1/29![Frontier logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:49 pm
CLT
- STL
1 stop7h 38m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/99:56 pm
CLT
- STL
1 stop25h 31m
Frontier
Deal found 1/28![Frontier logo]()
$80
This Trip.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/248:56 am
CLT
- MCI
1 stop26h 27m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$83
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:13 pm
CLT
- MCI
1 stop27h 33m
Frontier
Deal found 1/29![Frontier logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:00 pm
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/510:46 pm
CLT
- STL
1 stop9h 16m
Frontier
Deal found 1/28![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:35 pm
CHS
- MCI
1 stop16h 55m
Spirit Airlines
Deal found 1/27![Spirit Airlines logo]()
$90
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/309:22 pm
CLT
- MCI
1 stop14h 01m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:24 pm
CLT
- MCI
1 stop22h 06m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$92
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated January 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $139 (Kiwi.com) |
One-way from | $64 (Priceline) |
Popular in | January |
Cheapest in | August |
Average price | $504 |
Good round-trip deal | $376 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
South Carolina
Fly to
Missouri
Route
Depart
Return
Price
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 2/28
9:28 am-11:59 pm
1 stop15h 31m
Lambert-St Louis
Mon 3/2
3:49 pm-1:51 pm
1 stop21h 02m
$139
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 2/28
5:49 pm-11:59 pm
1 stop7h 10m
Lambert-St Louis
Mon 3/2
8:22 pm-1:51 pm
2 stops16h 29m
$168
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Mon 2/23
10:42 pm-3:29 pm
1 stop17h 47m
Kansas City
Sun 3/1
11:26 am-8:26 am
1 stop20h 00m
$188
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 3/4
2:46 pm-10:27 pm
1 stop8h 41m
Lambert-St Louis
Thu 3/5
3:49 pm-5:05 pm
1 stop24h 16m
$190
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Fri 2/20
3:21 pm-12:27 am
1 stop10h 06m
Lambert-St Louis
Mon 2/23
3:49 pm-8:38 am
1 stop15h 49m
$191
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 2/25
2:46 pm-10:27 pm
1 stop8h 41m
Lambert-St Louis
Thu 2/26
10:11 pm-4:18 pm
2 stops17h 07m
$207
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Thu 2/26
7:13 pm-10:30 am
1 stop16h 17m
Kansas City
Thu 3/5
11:26 am-11:56 pm
1 stop11h 30m
$210
CharlestonKansas City
CHS - MCI
CHSMCI
Charleston
Thu 4/16
7:00 am-11:07 am
1 stop29h 07m
Kansas City
Sat 4/25
12:12 pm-10:41 pm
1 stop9h 29m
$217
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Thu 2/26
3:12 pm-9:56 am
2 stops19h 44m
Kansas City
Tue 3/3
4:24 pm-10:17 am
1 stop16h 53m
$226
CharlotteKansas City
CLT - MCI
CLTMCI
Charlotte Douglas
Fri 2/27
7:20 pm-7:46 pm
2 stops25h 26m
Kansas City
Mon 3/2
11:26 am-11:56 pm
1 stop11h 30m
$230
Showing 1-10 of 60 results
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CLT-STL
CLT-MCI
CHS-MCI
CHS-STL
GSP-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CLT-STL
CLT-MCI
CHS-MCI
CHS-STL
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, June is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $108). Flying from South Carolina to Missouri in December is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2026.
It’s optimal to fly from South Carolina to Missouri in the afternoon. By choosing this option you can save up to 22% on the cost of your flight, compared to a flight at noon.
What is the cheapest day to fly from South Carolina to Missouri?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Missouri. Price data was last updated on January 24, 2026.
Travelers seeking maximum savings on their South Carolina to Missouri flight should consider departing on Tuesday mornings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 30, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$350 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$174 | Average$382 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$204 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$226 | Average$437 | FlexibilityNo cancel fee | On-time63% |