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$64+ Cheap flights from San Diego (SAN) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Jan 26 — Feb 21
Mon 1/26
Mon 2/2
1 adult, Economy
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Cheap flight deals from San Diego to Missouri

Cheapest flights from San Diego to Missouri
Explore the most affordable flight options available from San Diego to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:14 pmSAN - STL
1 stop20h 33mFrontier
Wed 12/314:27 pmSTL - SAN
2 stops19h 30mFrontier
Deal found 12/24$344
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:00 amSAN - MCI
1 stop5h 07mUnited Airlines
Fri 1/25:07 pmMCI - SAN
1 stop7h 25mUnited Airlines
Deal found 12/26$397
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:14 pmSAN - STL
1 stop20h 33mFrontier
Fri 1/28:42 pmSTL - SAN
1 stop14h 05mFrontier
Deal found 12/24$399
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:50 amSAN - MCI
1 stop5h 10mAmerican Airlines
Sat 1/38:02 pmMCI - SAN
1 stop5h 57mAmerican Airlines
Deal found 12/25$419
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:20 amSAN - MCI
1 stop7h 37mDelta
Sun 1/45:59 pmMCI - SAN
1 stop7h 56mDelta
Deal found 12/25$425
This Expedia deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:47 pmSAN - STL
1 stop15h 15mFrontier
Sat 1/37:43 pmSTL - SAN
1 stop6h 16mFrontier
Deal found 12/24$432
This Kiwi.com deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:14 pmSAN - STL
1 stop20h 33mFrontier
Thu 1/15:19 pmSTL - SAN
2 stops41h 28mFrontier
Deal found 12/25$436
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:50 amSAN - STL
1 stop9h 38mAmerican Airlines
Sat 1/32:42 pmSTL - SAN
1 stop5h 55mAmerican Airlines
Deal found 12/24$438
This United Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2710:56 amSAN - STL
1 stop8h 47mUnited Airlines
Wed 12/3111:05 amSTL - SAN
1 stop9h 36mUnited Airlines
Deal found 12/25$451
This Southwest deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:15 pmSAN - STL
1 stop4h 50mSouthwest
Sat 1/35:35 amSTL - SAN
2 stops7h 35mSouthwest
Deal found 12/24$452
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:06 pmSAN - STL
2 stops18h 34mFrontier
Sun 1/410:10 pmSTL - SAN
1 stop16h 28mFrontier
Deal found 12/24$455
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:00 amSAN - SGF
1 stop8h 27mUnited Airlines
Sun 1/411:24 amSGF - SAN
1 stop9h 17mUnited Airlines
Deal found 12/24$459

Find flight deals from San Diego to Missouri

Keep the following information in mind while searching for San Diego to Missouri flight deals. Data was last updated December 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$136
(Kiwi.com)

One-way from

$64
(Frontier)

Popular in

December

Cheapest in

September

Average price

$498

Good round-trip deal

$352 or less

Good one-way deal

$129 or less
Provider with most accurate pricing for San Diego-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Lambert-St Louis flights.
Search Deals
From San Diego to Missouri
Search Deals
One-way flight from San Diego to Missouri
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from San Diego to Missouri.
Search Deals
Price to beat on a one-way flight from San Diego to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from San Diego to Missouri that are best for you.

Fly from

San Diego

Fly to

Missouri

Route

Depart

Return

Price

San DiegoKansas City

SAN - MCI

SANMCI

San Diego

Mon 2/9

11:49 am-7:51 pm

1 stop6h 02m

Kansas City

Sat 2/14

8:36 pm-12:08 am

1 stop5h 32m

$181

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 1/10

9:44 am-11:39 am

1 stop23h 55m

Lambert-St Louis

Wed 1/14

3:43 pm-10:55 am

1 stop21h 12m

$183

San DiegoKansas City

SAN - MCI

SANMCI

San Diego

Sat 1/17

2:57 pm-11:04 am

1 stop18h 07m

Kansas City

Sun 1/18

8:27 pm-7:36 pm

1 stop25h 09m

$193

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 1/28

7:00 am-9:06 pm

2 stops36h 06m

Lambert-St Louis

Sun 2/1

9:32 pm-8:51 am

1 stop13h 19m

$203

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sun 1/18

9:16 am-9:14 pm

1 stop9h 58m

Lambert-St Louis

Tue 1/27

5:42 pm-11:31 pm

2 stops31h 49m

$214

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 1/29

2:56 pm-8:48 pm

1 stop27h 52m

Lambert-St Louis

Sun 2/1

12:03 pm-12:08 am

1 stop14h 05m

$218

San DiegoKansas City

SAN - MCI

SANMCI

San Diego

Fri 1/23

6:30 am-7:51 pm

1 stop11h 21m

Kansas City

Thu 1/29

7:00 am-2:01 pm

1 stop9h 01m

$227

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 1/30

6:30 am-6:44 pm

1 stop10h 14m

Lambert-St Louis

Sun 2/1

12:03 pm-7:21 pm

1 stop9h 18m

$252

San DiegoKansas City

SAN - MCI

SANMCI

San Diego

Sun 1/25

2:20 pm-11:51 pm

1 stop7h 31m

Kansas City

Wed 2/4

1:22 pm-6:51 pm

1 stop7h 29m

$269

San DiegoKansas City

SAN - MCI

SANMCI

San Diego

Tue 3/3

7:26 pm-1:55 pm

1 stop16h 29m

Kansas City

Tue 3/10

2:49 pm-9:49 pm

1 stop9h 00m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Showing 1-10 of 52 results
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Best time to book a flight from San Diego to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Missouri

What is the cheapest month to book a flight from San Diego to Missouri?

Currently, September is the cheapest month in which you can book a flight from San Diego to Missouri (average of $71). Flying from San Diego to Missouri in March is currently the most expensive (average of $192). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to MO?

Find hourly flight availability from San Diego to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 27, 2025.

One of the essential ways to save on airfare from San Diego to Missouri is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 16% on airfare.

What is the cheapest day to fly from San Diego to Missouri?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Missouri flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 27, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from San Diego to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Southwest
8.0
Very good
4,258 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Delta
7.9
Good
8,018 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
United Airlines
7.4
Good
9,116 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
American Airlines
7.2
Good
11,068 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Frontier
5.8
Fair
3,071 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to Missouri?

    Most people fly from San Diego (SAN) if they book a flight from San Diego to Missouri. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • How popular is this San Diego to Missouri flight route?

    Within the past month, 3 users have taken a look at flights from San Diego to Missouri.

  • How long is the flight from San Diego to Missouri?

    A quick flight from San Diego to Missouri can take about 6h 02m. Frontier provides one of the quickest options available for as low as $181. Airlines will cover a distance of 1330 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from San Diego to Missouri one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $57. However, be on the lookout for offers from Frontier and United Airlines, as they are both options that can get you from San Diego to Missouri for a low price.

  • What are the most popular routes from San Diego to Missouri?

    The most popular flight routes from San Diego to Missouri are San Diego - Kansas City, San Diego - Lambert-St Louis and San Diego - Springfield-Branson.

  • What are the cheapest flights from San Diego to Missouri?

    The cheapest flight price from San Diego to Missouri is $128. On average you can expect to pay $368. The most popular route, (San Diego - Kansas City), can usually be booked for $163.

  • Can I find deals for flights from San Diego to Missouri that include hotel bookings?

    Yes. In addition to deals on San Diego to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Missouri.

  • Can I find deals for business class flights from San Diego to Missouri?

    Yes. Cheapflights offers flight deals from San Diego to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Missouri?

    Currently, September is the cheapest month in which you can book a flight from San Diego to Missouri (average of $71). Flying from San Diego to Missouri in March is currently the most expensive (average of $192). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 6 airlines flying from San Diego to Missouri

Discover the top 6 airlines that operate flights from San Diego to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$96Average$216FlexibilityNo cancel feeOn-time65%
FrontierCheapest$104Average$239FlexibilityNo cancel feeOn-time62%
DeltaCheapest$138Average$284FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$221Average$377FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$227Average$402FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$268Average$482FlexibilityNo cancel feeOn-time63%

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