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$258+ Cheap flights from Panama City (PTY) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Panama City to Missouri

Cheapest flights from Panama City to Missouri
Explore the most affordable flight options available from Panama City to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:35 amPTY - MCI
2 stops22h 43mUnited Airlines
Wed 1/78:00 amMCI - PTY
2 stops10h 38mUnited Airlines
Deal found 10/29$418
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:41 pmPTY - MCI
2 stops17h 37mUnited Airlines
Thu 1/18:09 amMCI - PTY
1 stop7h 58mUnited Airlines
Deal found 10/30$451
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:55 amPTY - MCI
1 stop8h 43mUnited Airlines
Thu 12/1110:36 amMCI - PTY
1 stop27h 09mUnited Airlines
Deal found 10/30$469
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:43 pmPTY - MCI
2 stops21h 02mAmerican Airlines
Thu 12/116:39 pmMCI - PTY
2 stops20h 03mAmerican Airlines
Deal found 10/30$471
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:55 pmPTY - STL
2 stops18h 55mAmerican Airlines
Thu 1/16:35 pmSTL - PTY
2 stops20h 19mAmerican Airlines
Deal found 10/30$551
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/288:55 amPTY - MCI
1 stop14h 33mUnited Airlines
Fri 12/53:00 pmMCI - PTY
1 stop25h 07mUnited Airlines
Deal found 10/29$552
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:55 amPTY - STL
1 stop14h 27mUnited Airlines
Mon 11/246:43 pmSTL - PTY
2 stops23h 55mUnited Airlines
Deal found 10/30$601
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:41 pmPTY - STL
2 stops19h 10mUnited Airlines
Tue 11/1111:20 amSTL - PTY
1 stop7h 18mUnited Airlines
Deal found 10/29$657
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:53 pmPTY - STL
1 stop8h 42mAmerican Airlines
Sat 12/278:01 pmSTL - PTY
2 stops18h 53mAmerican Airlines
Deal found 10/29$671
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:41 pmPTY - SGF
2 stops23h 58mUnited Airlines
Mon 11/33:20 pmSGF - PTY
2 stops22h 25mUnited Airlines
Deal found 10/28$695
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/24:41 pmPTY - MCI
1 stop17h 48mUnited Airlines
Tue 11/44:35 pmMCI - PTY
1 stop26h 03mUnited Airlines
Deal found 10/29$695
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/272:55 amPTY - MCI
2 stops16h 41mMultiple Airlines
Fri 12/57:01 pmMCI - PTY
3 stops28h 59mMultiple Airlines
Deal found 10/29$751

Cheap flight deals from Panama City to Missouri

Keep the following information in mind while searching for Panama City to Missouri flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$418
(United Airlines)

One-way from

$258
(United Airlines)

Popular in

July

Cheapest in

February

Average price

$541
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama City Tocumen Intl to Missouri
Search Deals
One-way flight from Panama City Tocumen Intl to Missouri
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($1 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to Missouri that are best for you.

Fly from

Panama City

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 1/20

4:41 pm-2:27 pm

2 stops22h 46m

Kansas City

Tue 1/27

6:30 pm-8:02 pm

2 stops24h 32m

$418

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 12/23

11:35 am-9:18 am

2 stops22h 43m

Kansas City

Wed 1/7

6:30 pm-5:07 pm

2 stops21h 37m

$418

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Mon 1/19

4:41 pm-10:32 am

2 stops18h 51m

Kansas City

Mon 1/26

8:05 am-7:38 pm

1 stop10h 33m

$418

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Thu 4/2

7:55 am-3:53 pm

1 stop7h 58m

Springfield-Branson

Mon 4/6

8:50 am-4:12 pm

1 stop7h 22m

$548

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 12/20

4:55 pm-10:50 am

2 stops18h 55m

Lambert-St Louis

Thu 1/1

6:35 pm-3:54 pm

2 stops20h 19m

$551

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 11/20

4:41 pm-12:28 pm

2 stops20h 47m

Lambert-St Louis

Mon 11/24

5:24 pm-2:45 pm

2 stops20h 21m

$601

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/23

2:53 pm-10:35 pm

1 stop8h 42m

Lambert-St Louis

Sat 12/27

8:01 pm-3:54 pm

2 stops18h 53m

$671

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 1/5

4:55 pm-9:08 am

1 stop17h 13m

Lambert-St Louis

Thu 1/15

3:37 pm-1:27 pm

2 stops20h 50m

$700

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 11/19

2:55 am-11:57 pm

2 stops22h 02m

Lambert-St Louis

Mon 11/24

6:15 am-7:23 pm

1 stop12h 08m

$892

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 12/16

8:55 am-10:39 am

2 stops26h 44m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 22 results
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Best time to book a flight from Panama City to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Missouri

What is the cheapest month to book a flight from Panama City to Missouri?

Currently, August is the cheapest month in which you can book a flight from Panama City to Missouri (average of $237). Flying from Panama City to Missouri in January is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MO?

Find hourly flight availability from Panama City to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s typically best to fly out from Panama City to Missouri in the evening. Doing so could potentially save you 13% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown United Airlines from Panama City to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,998 reviews

Food

6.6

Comfort

7.3

Entertainment

7.1

Crew

8.1

Overall

7.4

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,998 reviews
United Airlines
7.4
Good
8,998 reviews

Food

6.6

Comfort

7.3

Entertainment

7.1

Crew

8.1

Overall

7.4

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Panama City to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Missouri?

    For a flight from Panama City to Missouri, you will be flying from Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city.

  • How long is the flight from Panama City to Missouri?

    United Airlines and American Airlines can get you from Panama City to Missouri in just under 18h 55m. Your travel time can differ by up to 3h 51m. Panama City and Missouri are separated by a distance of 2159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Missouri one-way?

    $258 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $258 and $317, respectively.

  • What are the most popular routes from Panama City to Missouri?

    The most popular flight routes from Panama City to Missouri are Panama City Tocumen Intl - Kansas City, Panama City Tocumen Intl - Lambert-St Louis and Panama City Tocumen Intl - Springfield-Branson.

  • Can I find deals for flights from Panama City to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama City to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Missouri.

  • Can I find deals for business class flights from Panama City to Missouri?

    Yes. Cheapflights offers flight deals from Panama City to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Panama City to Missouri (average of $237). Flying from Panama City to Missouri in January is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Panama City to Missouri

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Top airline flying from Panama City to Missouri

Discover the top airline that operate flights from Panama City to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$598FlexibilityNo cancel feeOn-time69%

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