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Mississippi

$114+ Cheap flights from Iowa to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Apr 26 — May 31
Sun 4/26
Sun 5/3
1 adult, Economy
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Cheap flight deals from Iowa to Mississippi

Cheapest flights from Iowa to Mississippi
Explore the most affordable flight options available from Iowa to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 27, 2026.

This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:19 pm
OMA
-
MEM
1 stop22h 50m
Frontier
Fri 5/227:54 pm
MEM
-
OMA
1 stop23h 40m
Frontier
Deal found 3/25$162
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:44 am
DSM
-
MEM
1 stop6h 44m
American Airlines
Tue 4/215:40 am
MEM
-
DSM
1 stop5h 46m
American Airlines
Deal found 3/23$227
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:10 pm
DSM
-
MEM
1 stop4h 37m
United Airlines
Sat 4/189:50 am
MEM
-
DSM
1 stop4h 38m
United Airlines
Deal found 3/24$249
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:44 pm
DSM
-
MEM
1 stop6h 15m
Delta
Wed 4/227:21 am
MEM
-
DSM
1 stop6h 34m
Delta
Deal found 3/26$250
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:09 am
DSM
-
MEM
2 stops8h 38m
American Airlines
Sat 4/186:40 am
MEM
-
DSM
1 stop7h 06m
American Airlines
Deal found 3/24$254
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
-
MEM
2 stops10h 40m
Southwest
Tue 4/213:25 pm
MEM
-
DSM
2 stops6h 45m
Southwest
Deal found 3/23$269
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Wed 4/226:00 am
MEM
-
DSM
2 stops8h 05m
Southwest
Deal found 3/26$270
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
-
MEM
1 stop6h 05m
Southwest
Sat 5/165:00 am
MEM
-
DSM
1 stop6h 30m
Southwest
Deal found 3/25$271
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:51 am
DSM
-
MEM
1 stop5h 03m
Delta
Mon 5/45:59 pm
MEM
-
DSM
1 stop4h 35m
Delta
Deal found 3/25$272
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:01 pm
DSM
-
MEM
1 stop6h 58m
American Airlines
Thu 4/235:40 am
MEM
-
DSM
1 stop5h 46m
American Airlines
Deal found 3/26$273
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
DSM
-
MEM
2 stops8h 25m
Southwest
Mon 5/45:05 am
MEM
-
DSM
1 stop6h 40m
Southwest
Deal found 3/25$277
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:19 pm
OMA
-
MEM
1 stop6h 33m
American Airlines
Sat 4/186:40 am
MEM
-
OMA
1 stop5h 03m
American Airlines
Deal found 3/23$284

Find flight deals from Iowa to Mississippi

Keep the following information in mind while searching for Iowa to Mississippi flight deals. Data was last updated March 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$162
(Frontier)

One-way from

$114
(United Airlines)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Iowa to Mississippi
Search Deals
One-way flight from Iowa to Mississippi
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Iowa to Mississippi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 4/15

1:10 pm-5:47 pm

1 stop4h 37m

Memphis

Sat 4/18

9:50 am-2:28 pm

1 stop4h 38m

$249

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 4/22

5:30 am-11:45 am

1 stop6h 15m

Memphis

Mon 4/27

5:05 am-11:45 am

1 stop6h 40m

$250

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 5/2

11:51 am-4:54 pm

1 stop5h 03m

Memphis

Mon 5/4

5:59 pm-10:34 pm

1 stop4h 35m

$272

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 4/23

3:31 pm-10:04 pm

1 stop6h 33m

Memphis

Mon 4/27

6:45 pm-11:17 pm

1 stop4h 32m

$273

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 5/2

5:35 am-2:00 pm

2 stops8h 25m

Memphis

Mon 5/4

5:05 am-11:45 am

1 stop6h 40m

$277

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 4/15

6:55 am-5:35 pm

2 stops10h 40m

Memphis

Sat 4/18

5:25 am-1:30 pm

2 stops8h 05m

$278

OmahaGulfport

OMA - GPT

OMAGPT

Omaha Eppley Airfield

Tue 5/12

3:24 pm-11:26 pm

1 stop8h 02m

Gulfport Biloxi Regional

Sat 5/16

6:09 pm-12:22 am

1 stop6h 13m

$306

OmahaMemphis

OMA - MEM

OMAMEM

Omaha Eppley Airfield

Sat 5/9

6:20 am-4:50 pm

1 stop10h 30m

Memphis

Thu 5/14

5:40 am-10:15 am

1 stop4h 35m

$308

MolineMemphis

MLI - MEM

MLIMEM

Moline Quad-City

Thu 5/21

6:56 pm-10:55 pm

1 stop3h 59m

Memphis

Sun 5/24

5:48 pm-11:55 pm

1 stop6h 07m

$309

MolineMemphis

MLI - MEM

MLIMEM

Moline Quad-City

Thu 6/4

5:56 am-11:39 am

1 stop5h 43m

Memphis

Sun 6/7

5:54 pm-10:34 pm

1 stop4h 40m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Mississippi

What is the cheapest month to book a flight from Iowa to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Iowa to Mississippi (average of $248). Flying from Iowa to Mississippi in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated March 27, 2026.
Get a feel of what it's like to fly with American Airlines from Iowa to Mississippi by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,507 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Overall

7.1

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,507 reviews
American Airlines
7.1
Good
11,507 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Overall

7.1

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Iowa to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Mississippi?

    A quick flight from Iowa to Mississippi can take about 4h 37m. United Airlines provides one of the quickest options available for as low as $249. There are 491 mi between Iowa and Mississippi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to Mississippi that include hotel bookings?

    Yes. In addition to deals on Iowa to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Mississippi.

  • Can I find deals for business class flights from Iowa to Mississippi?

    Yes. Cheapflights offers flight deals from Iowa to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Mississippi (average of $248). Flying from Iowa to Mississippi in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Iowa to Mississippi

Discover the top airline that operate flights from Iowa to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$463FlexibilityNo cancel feeOn-time71%

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