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$128+ Cheap flights from Iowa to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Iowa to Mississippi

Cheapest flights from Iowa to Mississippi
Explore the most affordable flight options available from Iowa to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:08 pmOMA - AEX
1 stop5h 27mDelta
Thu 1/14:44 pmAEX - OMA
1 stop5h 08mDelta
Deal found 12/17$308
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:40 amDSM - MEM
1 stop4h 49mAmerican Airlines
Sat 1/35:00 amMEM - DSM
1 stop8h 14mAmerican Airlines
Deal found 12/17$348
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:35 pmOMA - BTR
1 stop6h 58mAmerican Airlines
Tue 12/235:53 pmBTR - OMA
1 stop5h 06mAmerican Airlines
Deal found 12/16$354
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:15 amOMA - BTR
1 stop7h 32mUnited Airlines
Mon 12/2212:11 pmBTR - OMA
1 stop7h 08mUnited Airlines
Deal found 12/16$369
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/181:18 pmDSM - MOB
2 stops10h 38mAmerican Airlines
Sat 12/205:13 amMOB - DSM
1 stop5h 34mAmerican Airlines
Deal found 12/14$374
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:12 amOMA - AEX
2 stops11h 26mAmerican Airlines
Thu 1/16:19 pmAEX - OMA
1 stop4h 40mAmerican Airlines
Deal found 12/17$379
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:35 amOMA - BTR
1 stop4h 13mAmerican Airlines
Sun 1/42:18 pmBTR - OMA
1 stop4h 18mAmerican Airlines
Deal found 12/16$394
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:05 amOMA - BTR
2 stops10h 18mUnited Airlines
Sun 12/2812:11 pmBTR - OMA
1 stop7h 08mUnited Airlines
Deal found 12/17$414
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:09 pmDSM - MEM
1 stop6h 04mAmerican Airlines
Sun 1/47:05 amMEM - DSM
2 stops7h 48mAmerican Airlines
Deal found 12/16$419
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:44 pmOMA - MOB
1 stop7h 00mAmerican Airlines
Sat 1/36:45 pmMOB - OMA
1 stop5h 14mAmerican Airlines
Deal found 12/17$427
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:09 pmDSM - MOB
1 stop5h 21mAmerican Airlines
Sun 1/46:45 pmMOB - DSM
1 stop5h 52mAmerican Airlines
Deal found 12/16$437
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:04 amOMA - AEX
1 stop4h 32mAmerican Airlines
Mon 1/56:19 pmAEX - OMA
1 stop4h 17mAmerican Airlines
Deal found 12/15$447

Find flight deals from Iowa to Mississippi

Keep the following information in mind while searching for Iowa to Mississippi flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$250
(Delta)

One-way from

$128
(United Airlines)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Iowa to Mississippi
Search Deals
One-way flight from Iowa to Mississippi
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Iowa to Mississippi that are best for you.

Fly from

Iowa

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/18

6:54 am-11:43 am

1 stop4h 49m

Memphis

Thu 1/22

10:32 am-5:08 pm

1 stop6h 36m

$250

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 1/31

1:03 pm-7:28 pm

1 stop6h 25m

Memphis

Sat 2/7

6:00 am-12:15 pm

1 stop6h 15m

$251

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/18

5:01 pm-11:07 pm

1 stop6h 06m

Memphis

Thu 1/22

6:35 am-4:24 pm

2 stops9h 49m

$255

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 1/31

11:42 am-5:15 pm

1 stop5h 33m

Memphis

Sat 2/7

8:37 am-4:24 pm

2 stops7h 47m

$257

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Wed 4/1

11:17 am-6:52 pm

1 stop7h 35m

Mobile

Wed 4/8

5:28 am-11:57 am

1 stop6h 29m

$269

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Tue 3/24

5:20 pm-11:02 pm

1 stop5h 42m

Mobile

Tue 3/31

6:00 am-10:39 am

1 stop4h 39m

$269

OmahaBaton Rouge

OMA - BTR

OMABTR

Omaha Eppley Airfield

Thu 1/8

5:30 am-1:30 pm

1 stop8h 00m

Baton Rouge Ryan

Mon 1/12

2:19 pm-7:10 pm

1 stop4h 51m

$269

OmahaMobile

OMA - MOB

OMAMOB

Omaha Eppley Airfield

Wed 1/28

11:00 am-6:16 pm

1 stop7h 16m

Mobile

Sat 2/7

6:00 am-11:00 am

1 stop5h 00m

$269

OmahaMobile

OMA - MOB

OMAMOB

Omaha Eppley Airfield

Tue 2/10

5:30 am-11:45 am

1 stop6h 15m

Mobile

Thu 2/19

6:58 pm-11:57 pm

1 stop4h 59m

$269

OmahaMobile

OMA - MOB

OMAMOB

Omaha Eppley Airfield

Wed 1/28

5:04 pm-11:16 pm

1 stop6h 12m

Mobile

Sat 2/7

6:33 am-4:50 pm

2 stops10h 17m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 53 results
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Best time to book a flight from Iowa to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Mississippi

What is the cheapest month to book a flight from Iowa to Mississippi?

Currently, July is the cheapest month in which you can book a flight from Iowa to Mississippi (average of $248). Flying from Iowa to Mississippi in June is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated December 18, 2025.
Get a feel of what it's like to fly with American Airlines from Iowa to Mississippi by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,055 reviews

Crew

8.0

Boarding

7.5

Food

6.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,055 reviews
American Airlines
7.2
Good
11,055 reviews

Crew

8.0

Boarding

7.5

Food

6.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Iowa to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to Mississippi?

    A quick flight from Iowa to Mississippi can take about 4h 49m. Delta provides one of the quickest options available for as low as $250. There are 491 mi between Iowa and Mississippi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to Mississippi that include hotel bookings?

    Yes. In addition to deals on Iowa to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Mississippi.

  • Can I find deals for business class flights from Iowa to Mississippi?

    Yes. Cheapflights offers flight deals from Iowa to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Mississippi?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Mississippi (average of $248). Flying from Iowa to Mississippi in June is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Iowa to Mississippi

Discover the top airline that operate flights from Iowa to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$328FlexibilityNo cancel feeOn-time71%

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