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$367+ Cheap flights from Florence, SC (FLO) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — JAN
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Florence to Mississippi

Keep the following information in mind while searching for Florence to Mississippi flight deals. Data was last updated September 17, 2025.

Round-trip from

$387
(American Airlines)

One-way from

$367
(American Airlines)
From Florence to Mississippi
Search Deals
One-way flight from Florence to Mississippi
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Find flight deals from Florence to Mississippi

Cheapest flights from Florence to Mississippi
Explore the most affordable flight options available from Florence to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:11 amFLO - JAN
1 stop5h 52mAmerican Airlines
Wed 10/2910:00 amJAN - FLO
1 stop3h 54mAmerican Airlines
Deal found 9/15$387
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2311:11 amFLO - JAN
1 stop5h 52mAmerican Airlines
Tue 10/288:08 amJAN - FLO
1 stop5h 46mAmerican Airlines
Deal found 9/16$411
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/172:29 pmFLO - JAN
1 stop4h 49mAmerican Airlines
Sun 10/195:10 amJAN - FLO
1 stop4h 36mAmerican Airlines
Deal found 9/17$435
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:14 amFLO - JAN
1 stop4h 18mAmerican Airlines
Sun 10/126:43 pmJAN - FLO
1 stop4h 20mAmerican Airlines
Deal found 9/16$442
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2311:11 amFLO - JAN
2 stops11h 50mAmerican Airlines
Mon 10/277:20 amJAN - FLO
2 stops15h 43mAmerican Airlines
Deal found 9/17$452
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:14 amFLO - JAN
2 stops16h 47mAmerican Airlines
Tue 10/287:20 amJAN - FLO
2 stops14h 53mAmerican Airlines
Deal found 9/16$649

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Florence to Mississippi that are best for you.

Fly from

Florence

Fly to

Mississippi

Route

Depart

Return

Price

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Sat 10/25

11:11 am-4:03 pm

1 stop5h 52m

Jackson-Evers Intl

Tue 10/28

10:00 am-2:54 pm

1 stop3h 54m

$387

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Sat 10/25

11:11 am-4:03 pm

1 stop5h 52m

Jackson-Evers Intl

Wed 10/29

10:00 am-2:54 pm

1 stop3h 54m

$387

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Thu 10/23

11:11 am-4:03 pm

1 stop5h 52m

Jackson-Evers Intl

Tue 10/28

8:08 am-2:54 pm

1 stop5h 46m

$411

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Fri 10/24

3:19 pm-8:37 pm

1 stop6h 18m

Jackson-Evers Intl

Tue 10/28

8:08 am-2:54 pm

1 stop5h 46m

$411

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Fri 10/17

2:29 pm-6:18 pm

1 stop4h 49m

Jackson-Evers Intl

Sun 10/19

5:10 am-10:46 am

1 stop4h 36m

$435

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Sun 10/19

2:29 pm-6:18 pm

1 stop4h 49m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Florence to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Mississippi

What is the cheapest month to book a flight from Florence, South Carolina to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Mississippi (average of $371). Flying from Florence, South Carolina to Mississippi in March is currently the most expensive (average of $447). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Mississippi?

    For a flight from Florence to Mississippi, you will be flying from Florence. Florence (FLO) is just 2.3 mi from the center of the city.

  • How long is the flight from Florence, South Carolina to Mississippi?

    A quick flight from Florence, South Carolina to Mississippi can take about 5h 52m. American Airlines provides one of the quickest options available for as low as $387. The distance from Florence, South Carolina to Mississippi is about 611 mi.

  • What are the most popular routes from Florence, South Carolina to Mississippi?

    The most popular flight routes from Florence, South Carolina to Mississippi are Florence - Jackson-Evers Intl, Florence - Meridian Key Field and Florence - Laurel Hattiesburg-PineBelt.

  • Can I find deals for flights from Florence to Mississippi that include hotel bookings?

    Yes. In addition to deals on Florence to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Mississippi.

  • Can I find deals for business class flights from Florence to Mississippi?

    Yes. Cheapflights offers flight deals from Florence to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Mississippi (average of $371). Flying from Florence, South Carolina to Mississippi in March is currently the most expensive (average of $447). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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