$116+ Cheap flights from San Diego to Knoxville (SAN - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from San Diego to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from San Diego to Knoxville McGhee Tyson are usually found in July or January, booked 33 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday
Cheap flight deals from San Diego to Knoxville
Cheapest flights from San Diego to KnoxvilleExplore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Find flight deals from San Diego to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $148 (Frontier) |
One-way from | $116 (Frontier) |
Popular in | November |
Cheapest in | July |
Average price | $439 |
Cheapflights Fare Finder
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Fri 1/30
6:30 am-3:30 pm
1 stop6h 00m
Knoxville McGhee Tyson
Fri 2/6
4:25 pm-12:08 am
1 stop10h 43m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Mon 1/26
6:30 am-3:35 pm
1 stop6h 05m
Knoxville McGhee Tyson
Mon 2/2
4:30 pm-12:08 am
1 stop10h 38m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Sat 5/2
10:30 pm-10:10 am
1 stop8h 40m
Knoxville McGhee Tyson
Tue 5/5
11:30 am-6:23 pm
1 stop9h 53m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Tue 4/7
10:50 am-11:19 pm
2 stops9h 29m
Knoxville McGhee Tyson
Tue 4/14
7:00 am-11:25 am
1 stop7h 25m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Tue 5/5
10:55 am-11:40 pm
2 stops9h 45m
Knoxville McGhee Tyson
Sat 5/9
9:00 am-1:50 pm
1 stop7h 50m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Wed 5/20
6:20 am-6:14 pm
2 stops8h 54m
Knoxville McGhee Tyson
Wed 5/27
5:50 am-11:08 am
1 stop8h 18m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Sat 4/4
1:37 pm-11:40 pm
1 stop7h 03m
Knoxville McGhee Tyson
Tue 4/7
6:28 pm-9:53 pm
1 stop6h 25m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Mon 4/6
10:30 pm-9:16 am
1 stop7h 46m
Knoxville McGhee Tyson
Wed 4/15
5:15 pm-9:44 pm
1 stop7h 29m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Sat 2/14
1:53 pm-11:44 pm
1 stop6h 51m
Knoxville McGhee Tyson
Tue 2/24
10:55 am-8:49 pm
2 stops12h 54m
San DiegoKnoxville
SAN - TYS
SANTYS
San Diego
Sat 5/2
12:40 pm-10:23 pm
1 stop6h 43m
Knoxville McGhee Tyson
Tue 5/5
10:49 am-9:12 pm
2 stops13h 23m
Compare providers for flights from San Diego to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Knoxville in December.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Diego-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Diego-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Diego-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Knoxville
How far ahead should I book a flight from San Diego to Knoxville?
Booking 33 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Diego to Knoxville?
Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $42). Flying from San Diego to Knoxville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to TYS?
It’s typically best to fly out from San Diego to Knoxville at noon. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.
What is the cheapest day to fly from San Diego to Knoxville?
Travelers seeking maximum savings on their San Diego to Knoxville flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
How often are flights from San Diego to Knoxville delayed?
About 100% of weekly flights between San Diego and Knoxville have experienced delays in the past year, with the average delay time being 78 minutes.
What is the most punctual flight time for San Diego to Knoxville flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Entertainment
Comfort
Crew
Overall
Food
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Entertainment
Comfort
Crew
Overall
Food
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Entertainment
Comfort
Crew
Overall
Food
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Entertainment
Comfort
Crew
Overall
Food
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Entertainment
Comfort
Crew
Overall
Food
Reviews
Michael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for San Diego to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from San Diego to Knoxville
Discover the top 4 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$65 | Average$315 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$228 | Average$442 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$391 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$440 | FlexibilityNo cancel fee | On-time71% |