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$123+ Cheap flights from San Diego to Knoxville (SAN - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — TYS
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Knoxville McGhee Tyson are usually found in January or July, booked 21 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from San Diego to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2025.

Round-trip from

$256
(Mytrip)

One-way from

$123
(Mytrip)

Popular in

December

Cheapest in

January

Average price

$338
From San Diego to Knoxville McGhee Tyson
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One-way flight from San Diego to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 4% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Diego to Knoxville

Cheapest flights from San Diego to Knoxville
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:15 amSAN - TYS
1 stop13h 15mMultiple Airlines
Mon 9/228:30 amTYS - SAN
1 stop16h 56mMultiple Airlines
Deal found 7/27$256
This Gotogate deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/212:05 pmSAN - TYS
1 stop25h 24mFrontier
Sun 8/105:25 pmTYS - SAN
1 stop19h 27mFrontier
Deal found 7/27$267
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/96:15 amSAN - TYS
1 stop7h 04mAmerican Airlines
Tue 9/164:37 pmTYS - SAN
1 stop6h 43mAmerican Airlines
Deal found 7/26$276
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2610:40 pmSAN - TYS
1 stop9h 54mDelta
Wed 9/35:45 amTYS - SAN
1 stop6h 42mDelta
Deal found 7/28$277
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2710:54 amSAN - TYS
2 stops9h 50mUnited Airlines
Wed 9/37:20 amTYS - SAN
1 stop6h 35mUnited Airlines
Deal found 7/26$300
This Alaska Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/266:15 amSAN - TYS
1 stop8h 34mAlaska Airlines
Wed 9/312:51 pmTYS - SAN
2 stops13h 07mAlaska Airlines
Deal found 7/26$372

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

San Diego

Fly to

Knoxville

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 9/19

6:15 am-10:30 pm

1 stop13h 15m

Knoxville McGhee Tyson

Mon 9/22

8:30 am-10:26 pm

1 stop16h 56m

$256

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 8/2

12:05 pm-4:29 pm

1 stop25h 24m

Knoxville McGhee Tyson

Sun 8/10

5:25 pm-9:52 am

1 stop19h 27m

$267

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 9/9

6:15 am-4:19 pm

1 stop7h 04m

Knoxville McGhee Tyson

Tue 9/16

4:37 pm-8:20 pm

1 stop6h 43m

$276

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 8/26

10:40 pm-11:34 am

1 stop9h 54m

Knoxville McGhee Tyson

Wed 9/3

5:45 am-9:27 am

1 stop6h 42m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 8/27

10:54 am-11:44 pm

2 stops9h 50m

Knoxville McGhee Tyson

Wed 9/3

7:20 am-10:55 am

1 stop6h 35m

$300

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Mon 9/15

11:30 am-10:16 pm

1 stop7h 46m

Knoxville McGhee Tyson

Mon 9/22

4:37 pm-12:56 pm

2 stops23h 19m

$384

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 10/15

7:47 pm-3:28 pm

1 stop16h 41m

$123

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 9/11

6:35 am-7:50 pm

1 stop10h 15m

$145

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 8/1

7:45 am-8:57 pm

1 stop10h 12m

$316

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 8/1

10:15 pm-10:14 am

1 stop8h 59m

$420

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 11 results
1
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Best time to book a flight from San Diego to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Knoxville

How far ahead should I book a flight from San Diego to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Knoxville. Price data was last updated on July 25, 2025.

Booking 21 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $295). Flying from San Diego to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to TYS?

Find hourly flight availability from San Diego to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

It’s typically best to fly out from San Diego to Knoxville at noon. Doing so could potentially save you 22% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from San Diego to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 28, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,971 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,893 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,238 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Boarding

8.1

Entertainment

7.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from San Diego to Knoxville round-trip?

    Cheapflights users have booked flights from San Diego to Knoxville round-trip from $267. Other airlines that can offer you cheap pricing are American Airlines, from $276, and Delta, from $277. These flights start at 37% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from San Diego to Knoxville one-way?

    One-way options have recently been found by users for as low as $145 on Frontier. Other airlines that offer cheap prices include United Airlines from $316 and Delta from $420 one-way.

  • Can I find deals for flights from San Diego to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Diego to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Knoxville.

  • Can I find deals for business class flights from San Diego to Knoxville?

    Yes. Cheapflights offers flight deals from San Diego to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $295). Flying from San Diego to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Alcoa
Oak Ridge
Murphy

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Top 5 airlines flying from San Diego to Knoxville

Discover the top 5 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$84Average$290FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$228Average$441FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$280Average$468FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$378Average$798FlexibilityNo cancel feeOn-time75%

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