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$76+ Cheap flights from San Diego to Knoxville (SAN - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — TYS
nov. 26 — dic. 31
mié. 11/26
mié. 12/3
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Knoxville McGhee Tyson are usually found in January or July, booked 90 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Find flight deals from San Diego to Knoxville

Cheapest flights from San Diego to Knoxville
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 27, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:47 pmSAN - TYS
1 stop20h 10mFrontier
lun. 12/154:52 pmTYS - SAN
1 stop10h 07mFrontier
Deal found 10/24$174
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:47 pmSAN - TYS
1 stop20h 10mFrontier
jue. 12/114:52 pmTYS - SAN
1 stop10h 07mFrontier
Deal found 10/24$175
This Frontier deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/86:34 amSAN - TYS
1 stop6h 23mFrontier
lun. 12/154:52 pmTYS - SAN
1 stop10h 07mFrontier
Deal found 10/24$176
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:47 pmSAN - TYS
1 stop20h 10mMultiple Airlines
dom. 12/146:30 amTYS - SAN
1 stop15h 45mMultiple Airlines
Deal found 10/24$190
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/410:57 amSAN - TYS
1 stop8h 25mMultiple Airlines
lun. 12/154:52 pmTYS - SAN
1 stop10h 07mMultiple Airlines
Deal found 10/24$191
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/410:57 amSAN - TYS
1 stop8h 25mMultiple Airlines
jue. 12/114:52 pmTYS - SAN
1 stop10h 07mMultiple Airlines
Deal found 10/24$193
This Frontier deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/86:34 amSAN - TYS
1 stop6h 23mFrontier
jue. 12/114:52 pmTYS - SAN
1 stop10h 07mFrontier
Deal found 10/24$196
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/410:57 amSAN - TYS
1 stop8h 25mMultiple Airlines
dom. 12/146:30 amTYS - SAN
1 stop15h 45mMultiple Airlines
Deal found 10/24$201
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/96:41 amSAN - TYS
1 stop8h 41mFrontier
jue. 11/137:17 pmTYS - SAN
1 stop19h 00mFrontier
Deal found 10/25$211
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:47 pmSAN - TYS
1 stop20h 10mMultiple Airlines
vie. 12/121:41 pmTYS - SAN
2 stops29h 11mMultiple Airlines
Deal found 10/24$212
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/410:57 amSAN - TYS
1 stop8h 25mMultiple Airlines
vie. 12/121:41 pmTYS - SAN
2 stops29h 11mMultiple Airlines
Deal found 10/24$223

Cheap flight deals from San Diego to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$174
(Kiwi.com)

One-way from

$76
(Booking.com)

Popular in

December

Cheapest in

January

Average price

$528
Provider with most accurate pricing for San Diego-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Knoxville McGhee Tyson flights.
Search Deals
From San Diego to Knoxville McGhee Tyson
Search Deals
One-way flight from San Diego to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

San Diego

Fly to

Knoxville

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dom. 12/7

6:34 am-3:57 pm

1 stop30h 23m

Knoxville McGhee Tyson

vie. 12/12

8:00 am-12:38 pm

1 stop7h 38m

$257

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

sáb. 1/24

10:26 am-7:50 pm

1 stop6h 24m

Knoxville McGhee Tyson

sáb. 1/31

11:07 am-3:36 pm

1 stop7h 29m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dom. 11/23

8:34 am-10:37 pm

1 stop11h 03m

Knoxville McGhee Tyson

lun. 11/24

12:33 pm-5:55 pm

1 stop8h 22m

$283

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dom. 11/9

10:15 am-6:23 pm

2 stops29h 08m

Knoxville McGhee Tyson

jue. 11/13

7:17 pm-11:17 am

1 stop19h 00m

$305

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

vie. 12/12

7:20 am-8:00 pm

1 stop9h 40m

Knoxville McGhee Tyson

mar. 12/16

5:40 am-9:54 am

1 stop7h 14m

$354

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

lun. 12/8

7:20 am-8:00 pm

1 stop9h 40m

Knoxville McGhee Tyson

sáb. 12/13

1:27 pm-6:18 pm

1 stop7h 51m

$354

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

jue. 11/6

9:14 am-10:58 pm

1 stop10h 44m

Knoxville McGhee Tyson

lun. 11/10

8:00 am-12:07 pm

2 stops31h 07m

$358

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

vie. 12/12

8:40 pm-10:13 am

2 stops10h 33m

Knoxville McGhee Tyson

mar. 12/16

7:05 am-11:01 am

1 stop6h 56m

$359

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

vie. 12/5

6:15 am-11:18 pm

2 stops14h 03m

Knoxville McGhee Tyson

sáb. 12/13

5:36 pm-9:18 pm

1 stop6h 42m

$361

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

sáb. 12/6

2:15 pm-10:30 am

2 stops17h 15m

Knoxville McGhee Tyson

sáb. 12/13

4:22 pm-10:13 am

2 stops20h 51m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 22 results
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Compare providers for flights from San Diego to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Diego-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Diego-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Diego-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Knoxville

How far ahead should I book a flight from San Diego to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Knoxville. Price data was last updated on October 24, 2025.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $42). Flying from San Diego to Knoxville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to TYS?

Find hourly flight availability from San Diego to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 27, 2025.

It’s typically best to fly out from San Diego to Knoxville at noon. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from San Diego to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Knoxville flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated octubre 27, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,192 reviews
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
7,996 reviews
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,999 reviews
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,031 reviews
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,123 reviews
Alaska Airlines
8.0
Very good
11,192 reviews

Overall

8.0

Crew

8.5

Food

7.1

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Knoxville?

    A quick flight from San Diego to Knoxville can take about 6h 24m. United Airlines provides one of the quickest options available for as low as $277. Airlines will cover a distance of 1897 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Diego to Knoxville round-trip?

    Cheapflights users have booked flights from San Diego to Knoxville round-trip from $84. Other airlines that can offer you cheap pricing are United Airlines, from $228, and Delta, from $276. These flights start at 80% lower than the current average price 3 months from now.

  • Can I find deals for flights from San Diego to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Diego to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Knoxville.

  • Can I find deals for business class flights from San Diego to Knoxville?

    Yes. Cheapflights offers flight deals from San Diego to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $42). Flying from San Diego to Knoxville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 5 airlines flying from San Diego to Knoxville

Discover the top 5 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$84Average$316FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$228Average$474FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$401FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$277Average$460FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$378Average$798FlexibilityNo cancel feeOn-time75%

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