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$106+ Cheap flights from San Diego to Knoxville (SAN - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Knoxville McGhee Tyson are usually found in January or July, booked 90 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from San Diego to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$241
(Kiwi.com)

One-way from

$106
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$423
From San Diego to Knoxville McGhee Tyson
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One-way flight from San Diego to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Diego to Knoxville

Cheapest flights from San Diego to Knoxville
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 amSAN - TYS
1 stop10h 15mMultiple Airlines
Sun 10/55:44 pmTYS - SAN
2 stops33h 09mMultiple Airlines
Deal found 9/9$241
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:29 pmSAN - TYS
1 stop6h 54mAmerican Airlines
Sat 11/16:47 pmTYS - SAN
1 stop6h 14mAmerican Airlines
Deal found 9/10$243
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:25 amSAN - TYS
1 stop13h 05mMultiple Airlines
Mon 9/298:35 pmTYS - SAN
1 stop28h 49mMultiple Airlines
Deal found 9/10$255
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:24 pmSAN - TYS
1 stop24h 58mMultiple Airlines
Mon 11/1712:50 pmTYS - SAN
2 stops27h 38mMultiple Airlines
Deal found 9/10$258
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/182:24 pmSAN - TYS
1 stop26h 08mMultiple Airlines
Sat 10/258:40 amTYS - SAN
2 stops52h 17mMultiple Airlines
Deal found 9/10$260
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:52 amSAN - TYS
1 stop8h 30mMultiple Airlines
Fri 12/121:41 pmTYS - SAN
2 stops45h 24mMultiple Airlines
Deal found 9/10$261
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:38 pmSAN - TYS
1 stop27h 36mMultiple Airlines
Thu 1/810:00 amTYS - SAN
1 stop26h 57mMultiple Airlines
Deal found 9/9$276
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/251:18 pmSAN - TYS
2 stops30h 03mMultiple Airlines
Sun 9/287:00 amTYS - SAN
1 stop7h 09mMultiple Airlines
Deal found 9/8$277
This Frontier deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:41 amSAN - TYS
1 stop9h 51mFrontier
Mon 10/278:17 pmTYS - SAN
1 stop6h 33mFrontier
Deal found 9/11$281
This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 amSAN - TYS
1 stop10h 15mFrontier
Sun 10/55:08 pmTYS - SAN
1 stop9h 45mFrontier
Deal found 9/9$283

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

San Diego

Fly to

Knoxville

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 10/18

2:29 pm-12:23 am

1 stop6h 54m

Knoxville McGhee Tyson

Sat 10/25

5:00 am-10:56 am

1 stop8h 56m

$243

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 9/26

6:25 am-10:30 pm

1 stop13h 05m

Knoxville McGhee Tyson

Mon 9/29

8:35 pm-10:24 pm

1 stop28h 49m

$255

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 12/4

12:38 pm-7:14 pm

1 stop27h 36m

Knoxville McGhee Tyson

Thu 1/8

10:00 am-9:57 am

1 stop26h 57m

$276

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 2/24

10:30 pm-10:17 am

1 stop8h 47m

Knoxville McGhee Tyson

Sat 2/28

2:30 pm-8:56 pm

1 stop9h 26m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 11/1

10:31 pm-9:34 am

1 stop8h 03m

Knoxville McGhee Tyson

Sat 11/15

4:27 pm-8:20 pm

1 stop6h 53m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 10/24

6:41 am-7:32 pm

1 stop9h 51m

Knoxville McGhee Tyson

Mon 10/27

8:17 pm-11:50 pm

1 stop6h 33m

$297

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 9/30

6:15 am-6:10 pm

2 stops8h 55m

Knoxville McGhee Tyson

Tue 10/7

4:40 pm-8:25 pm

1 stop6h 45m

$300

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 12/25

6:15 am-3:23 pm

1 stop6h 08m

Knoxville McGhee Tyson

Wed 12/31

12:18 pm-3:48 pm

1 stop6h 30m

$329

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 10/8

10:46 am-10:50 pm

1 stop9h 04m

Knoxville McGhee Tyson

Sat 10/11

10:51 am-8:49 pm

2 stops12h 58m

$338

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 10/25

10:30 pm-10:05 am

1 stop8h 35m

Knoxville McGhee Tyson

Sat 11/1

8:26 am-3:00 pm

2 stops9h 34m

$338

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 17 results
1
2

Best time to book a flight from San Diego to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Knoxville

How far ahead should I book a flight from San Diego to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Knoxville. Price data was last updated on August 29, 2025.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $294). Flying from San Diego to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to TYS?

Find hourly flight availability from San Diego to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from San Diego to Knoxville at noon. Doing so could potentially save you 22% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from San Diego to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
8.0
Very good
7,960 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,937 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,177 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Knoxville?

    A quick flight from San Diego to Knoxville can take about 6h 54m. American Airlines provides one of the quickest options available for as low as $243. Airlines will cover a distance of 1897 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Diego to Knoxville round-trip?

    Cheapflights users have booked flights from San Diego to Knoxville round-trip from $84. Other airlines that can offer you cheap pricing are United Airlines, from $228, and Delta, from $276. These flights start at 80% lower than the current average price 3 months from now.

  • Can I find deals for flights from San Diego to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Diego to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Knoxville.

  • Can I find deals for business class flights from San Diego to Knoxville?

    Yes. Cheapflights offers flight deals from San Diego to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $294). Flying from San Diego to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 5 airlines flying from San Diego to Knoxville

Discover the top 5 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$84Average$316FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$228Average$505FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$404FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$468FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$378Average$798FlexibilityNo cancel feeOn-time75%

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