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$182+ Cheap flights from Oregon to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — TYS
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Oregon to Knoxville

Keep the following information in mind while searching for Oregon to Knoxville flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(United Airlines)

One-way from

$182
(Booking.com)

Popular in

March

Cheapest in

August

Average price

$406
Provider with most accurate pricing for Portland-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Portland-Knoxville McGhee Tyson flights.
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From Oregon to Knoxville McGhee Tyson
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One-way flight from Oregon to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 5% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Oregon to Knoxville

Cheapest flights from Oregon to Knoxville
Explore the most affordable flight options available from Oregon to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 am
MFR
-
TYS
1 stop7h 06m
United Airlines
Tue 4/284:30 pm
TYS
-
MFR
1 stop8h 07m
United Airlines
Deal found 1/13$317
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:31 pm
MFR
-
TYS
2 stops12h 37m
United Airlines
Tue 4/284:30 pm
TYS
-
MFR
1 stop8h 07m
United Airlines
Deal found 1/13$328
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:59 am
PDX
-
TYS
1 stop11h 20m
American Airlines
Wed 5/137:33 pm
TYS
-
PDX
1 stop7h 08m
American Airlines
Deal found 1/11$363
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:35 pm
PDX
-
TYS
1 stop7h 12m
American Airlines
Sat 2/142:54 pm
TYS
-
PDX
1 stop8h 50m
American Airlines
Deal found 1/12$367
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:56 pm
PDX
-
TYS
2 stops20h 10m
Multiple Airlines
Sun 3/18:30 am
TYS
-
PDX
1 stop12h 36m
Multiple Airlines
Deal found 1/11$370
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:59 pm
PDX
-
TYS
1 stop7h 13m
United Airlines
Thu 3/124:18 pm
TYS
-
PDX
1 stop9h 42m
United Airlines
Deal found 1/13$372
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:00 am
BOI
-
TYS
1 stop8h 31m
American Airlines
Tue 3/174:29 pm
TYS
-
BOI
1 stop7h 54m
American Airlines
Deal found 1/13$379
This United Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:16 pm
BOI
-
TYS
1 stop6h 21m
United Airlines
Wed 2/186:45 am
TYS
-
BOI
1 stop7h 48m
United Airlines
Deal found 1/12$385
This United Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1711:59 pm
PDX
-
TYS
1 stop7h 20m
United Airlines
Wed 3/257:05 am
TYS
-
PDX
1 stop8h 30m
United Airlines
Deal found 1/12$385
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/281:16 pm
RDM
-
TYS
1 stop6h 15m
United Airlines
Sat 1/314:25 pm
TYS
-
RDM
1 stop7h 56m
United Airlines
Deal found 1/13$389
This United Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:25 am
BOI
-
TYS
2 stops12h 12m
United Airlines
Tue 2/176:45 am
TYS
-
BOI
1 stop7h 48m
United Airlines
Deal found 1/12$390
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/911:59 pm
PDX
-
TYS
1 stop7h 57m
American Airlines
Tue 4/213:58 pm
TYS
-
PDX
2 stops9h 34m
American Airlines
Deal found 1/12$390

Cheapflights Fare Finder

 
Customize your flight search to find flights from Oregon to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Oregon to Knoxville that are best for you.

Fly from

Oregon

Fly to

Knoxville

Route

Depart

Return

Price

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 4/21

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Tue 4/28

4:30 pm-9:37 pm

1 stop8h 07m

$317

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 4/20

6:31 pm-10:08 am

2 stops12h 37m

Knoxville McGhee Tyson

Tue 4/28

4:30 pm-9:37 pm

1 stop8h 07m

$328

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 2/11

12:35 pm-10:47 pm

1 stop7h 12m

Knoxville McGhee Tyson

Sat 2/14

2:54 pm-8:44 pm

1 stop8h 50m

$367

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 2/18

10:56 am-8:37 pm

1 stop6h 41m

Knoxville McGhee Tyson

Wed 2/25

6:45 am-11:55 am

1 stop8h 10m

$367

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 4/9

11:59 pm-10:56 am

1 stop7h 57m

Knoxville McGhee Tyson

Tue 4/21

4:09 pm-9:38 pm

1 stop8h 29m

$372

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 3/3

7:10 am-7:55 pm

1 stop9h 45m

Knoxville McGhee Tyson

Thu 3/12

7:00 am-11:51 am

1 stop7h 51m

$372

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Tue 2/24

7:00 am-5:31 pm

1 stop8h 31m

Knoxville McGhee Tyson

Tue 3/17

4:29 pm-10:23 pm

1 stop7h 54m

$379

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 4/8

12:30 am-4:43 pm

2 stops13h 13m

Knoxville McGhee Tyson

Tue 4/21

5:30 am-12:52 pm

2 stops10h 22m

$383

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Sat 2/14

1:41 pm-12:28 am

1 stop8h 47m

Knoxville McGhee Tyson

Tue 2/17

4:29 pm-10:22 pm

1 stop7h 53m

$385

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Sat 2/14

2:40 pm-10:30 pm

1 stop5h 50m

Knoxville McGhee Tyson

Tue 2/17

6:45 am-12:33 pm

1 stop7h 48m

$385

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/11

Showing 1-10 of 47 results
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Best time to book a flight from Oregon to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Oregon with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Oregon to Knoxville

What is the cheapest month to book a flight from Oregon to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Oregon to Knoxville (average of $128). Flying from Oregon to Knoxville in May is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Oregon to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Oregon?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Oregon.

  • How long is the flight from Oregon to Knoxville?

    Departing from Oregon to Knoxville will take you 7h 06m. Airlines will cover a distance of 2113 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Oregon to Knoxville one-way?

    $107 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $124 and $124, respectively.

  • What are the most popular routes from Oregon to Knoxville?

    The most popular flight routes from Oregon to Knoxville are Portland - Knoxville McGhee Tyson, Boise Air Term. Gowen Fld - Knoxville McGhee Tyson and Eugene - Knoxville McGhee Tyson.

  • Can I find deals for flights from Oregon to Knoxville that include hotel bookings?

    Yes. In addition to deals on Oregon to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Oregon to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Oregon to Knoxville.

  • Can I find deals for business class flights from Oregon to Knoxville?

    Yes. Cheapflights offers flight deals from Oregon to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Oregon to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Oregon to Knoxville (average of $128). Flying from Oregon to Knoxville in May is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from Oregon to Knoxville

Discover the top 4 airlines that operate flights from Oregon to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$240Average$290FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$278Average$567FlexibilityNo cancel feeOn-time69%
DeltaCheapest$278Average$435FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$291Average$483FlexibilityNo cancel feeOn-time71%

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