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Knoxville

$127+ Cheap flights from Oregon to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — TYS
Jun 22 — Jun 291
Mon 6/22
Mon 6/29
1 adult, Economy
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Cheap flight deals from Oregon to Knoxville

Cheapest flights from Oregon to Knoxville
Explore the most affordable flight options available from Oregon to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.

This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:29 pm
MFR
-
TYS
2 stops14h 42m
Delta
Tue 9/15:30 am
TYS
-
MFR
2 stops10h 03m
Delta
Deal found 5/20$367
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:25 pm
BOI
-
TYS
1 stop5h 31m
Delta
Tue 9/86:45 am
TYS
-
BOI
1 stop9h 18m
Delta
Deal found 5/22$375
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:34 pm
PDX
-
TYS
1 stop15h 24m
Multiple Airlines
Sun 9/277:00 am
TYS
-
PDX
1 stop12h 35m
Multiple Airlines
Deal found 5/20$382
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:29 pm
MFR
-
TYS
2 stops14h 42m
Delta
Mon 8/315:30 am
TYS
-
MFR
2 stops9h 48m
Delta
Deal found 5/20$384
This Booking.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:16 pm
PDX
-
TYS
1 stop23h 08m
Frontier
Wed 7/298:19 pm
TYS
-
PDX
1 stop23h 32m
Frontier
Deal found 5/22$388
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:40 am
PDX
-
TYS
1 stop9h 22m
American Airlines
Tue 6/235:33 pm
TYS
-
PDX
1 stop10h 17m
American Airlines
Deal found 5/19$395
This Mytrip deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:33 pm
BOI
-
TYS
1 stop28h 00m
Frontier
Mon 6/88:32 pm
TYS
-
BOI
1 stop17h 58m
Frontier
Deal found 5/19$399
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:58 am
PDX
-
TYS
1 stop8h 20m
American Airlines
Sat 8/2912:52 pm
TYS
-
PDX
1 stop10h 34m
American Airlines
Deal found 5/21$404
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:18 am
EUG
-
TYS
2 stops14h 00m
American Airlines
Sat 9/261:40 pm
TYS
-
EUG
2 stops12h 13m
American Airlines
Deal found 5/19$412
This deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2911:15 pm
PDX
-
TYS
1 stop8h 12m
Delta
Sat 7/46:45 am
TYS
-
PDX
1 stop8h 55m
Delta
Deal found 5/21$413
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:30 pm
BOI
-
TYS
1 stop7h 41m
Delta
Tue 9/86:45 am
TYS
-
BOI
1 stop9h 18m
Delta
Deal found 5/22$416
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:35 am
PDX
-
TYS
1 stop7h 10m
American Airlines
Tue 9/221:40 pm
TYS
-
PDX
1 stop8h 21m
American Airlines
Deal found 5/20$416

Find flight deals from Oregon to Knoxville

Keep the following information in mind while searching for Oregon to Knoxville flight deals. Data was last updated May 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$354
(Kiwi.com)

One-way from

$127
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$512
Provider with most accurate pricing for Portland-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Knoxville McGhee Tyson flights.
Search Deals
From Oregon to Knoxville McGhee Tyson
Search Deals
One-way flight from Oregon to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Oregon to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Oregon to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

5:29 pm-11:11 am

2 stops14h 42m

Knoxville McGhee Tyson

Wed 9/2

2:30 pm-11:13 pm

2 stops11h 43m

$367

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

5:00 am-3:54 pm

1 stop7h 54m

Knoxville McGhee Tyson

Wed 9/2

7:00 am-5:58 pm

2 stops13h 58m

$422

EugeneKnoxville

EUG - TYS

EUGTYS

Eugene

Tue 9/22

12:25 pm-12:05 pm

2 stops20h 40m

Knoxville McGhee Tyson

Sat 9/26

1:55 pm-9:15 pm

1 stop10h 20m

$424

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Sat 7/4

2:04 pm-12:02 am

1 stop7h 58m

Knoxville McGhee Tyson

Wed 7/8

5:40 am-12:53 pm

1 stop9h 13m

$426

EugeneKnoxville

EUG - TYS

EUGTYS

Eugene

Tue 9/22

5:45 am-6:17 pm

2 stops9h 32m

Knoxville McGhee Tyson

Thu 9/24

5:30 am-12:01 pm

2 stops9h 31m

$433

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Thu 9/17

11:30 pm-9:11 am

1 stop7h 41m

Knoxville McGhee Tyson

Fri 9/25

6:45 am-2:03 pm

1 stop9h 18m

$439

EugeneKnoxville

EUG - TYS

EUGTYS

Eugene

Sat 10/17

6:15 am-3:35 pm

1 stop6h 20m

Knoxville McGhee Tyson

Mon 10/26

5:25 pm-10:45 pm

1 stop8h 20m

$446
Quickest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 7/15

1:45 pm-11:01 pm

1 stop6h 16m

Knoxville McGhee Tyson

Wed 7/22

6:36 pm-11:18 pm

1 stop7h 42m

$447

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 9/11

7:35 pm-11:55 am

2 stops13h 20m

Knoxville McGhee Tyson

Tue 9/15

5:30 pm-11:10 pm

2 stops8h 40m

$452

BoiseKnoxville

BOI - TYS

BOITYS

Boise Air Term. Gowen Fld

Sat 8/22

1:50 pm-12:25 pm

2 stops20h 35m

Knoxville McGhee Tyson

Sun 8/30

7:35 am-2:50 pm

2 stops9h 15m

$461

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/20

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Oregon to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Oregon with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Oregon to Knoxville

What is the cheapest month to book a flight from Oregon to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Oregon to Knoxville (average of $139). Flying from Oregon to Knoxville in May is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Oregon to Knoxville?

How far ahead should I book a flight from Oregon to Knoxville?

To ensure you get the cheapest price possible for a flight from Oregon to Knoxville, you should look to book at least 76 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

Related info for your journey

Find useful and relevant information for your journey from Oregon to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Oregon?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Oregon.

  • How long is the flight from Oregon to Knoxville?

    Departing from Oregon to Knoxville will take you 7h 54m. Airlines will cover a distance of 2113 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Oregon to Knoxville one-way?

    $107 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $125 and $125, respectively.

  • What are the most popular routes from Oregon to Knoxville?

    The most popular flight routes from Oregon to Knoxville are Portland - Knoxville McGhee Tyson, Eugene - Knoxville McGhee Tyson and Boise Air Term. Gowen Fld - Knoxville McGhee Tyson.

  • Can I find deals for flights from Oregon to Knoxville that include hotel bookings?

    Yes. In addition to deals on Oregon to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Oregon to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Oregon to Knoxville.

  • Can I find deals for business class flights from Oregon to Knoxville?

    Yes. Cheapflights offers flight deals from Oregon to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Oregon to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Oregon to Knoxville (average of $139). Flying from Oregon to Knoxville in May is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top 4 airlines flying from Oregon to Knoxville

Discover the top 4 airlines that operate flights from Oregon to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$256Average$476FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$264Average$343FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$279Average$562FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$308Average$457FlexibilityNo cancel feeOn-time71%

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