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$387+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
oct. 31 — nov. 71
vie. 10/31
vie. 11/7
1 adult, Economy
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Cheap flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated octubre 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$387
(American Airlines)

Popular in

March

Cheapest in

July

Average price

$576
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
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From Odessa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 6% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 1, 2025.

This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/154:14 pmMAF - TYS
1 stop7h 09mAmerican Airlines
dom. 10/196:00 amTYS - MAF
1 stop4h 43mAmerican Airlines
Deal found 9/30$500
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/234:29 pmMAF - TYS
1 stop6h 16mAmerican Airlines
dom. 12/285:23 amTYS - MAF
1 stop5h 26mAmerican Airlines
Deal found 9/29$580
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/512:06 pmMAF - TYS
1 stop6h 46mUnited Airlines
mar. 10/75:20 pmTYS - MAF
1 stop5h 53mUnited Airlines
Deal found 9/29$597
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/55:30 amMAF - TYS
2 stops6h 37mDelta
mar. 10/78:15 amTYS - MAF
2 stops9h 16mDelta
Deal found 9/29$607
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/36:57 pmMAF - TYS
1 stop4h 11mAmerican Airlines
jue. 11/66:18 pmTYS - MAF
1 stop6h 37mAmerican Airlines
Deal found 9/29$649
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/1512:33 pmMAF - TYS
2 stops9h 34mDelta
dom. 10/195:44 amTYS - MAF
2 stops7h 09mDelta
Deal found 9/30$670
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/134:12 pmMAF - TYS
1 stop6h 39mAmerican Airlines
mar. 10/146:43 pmTYS - MAF
1 stop4h 51mAmerican Airlines
Deal found 9/29$692
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/159:46 amMAF - TYS
2 stops12h 04mUnited Airlines
dom. 10/199:30 amTYS - MAF
1 stop14h 44mUnited Airlines
Deal found 9/30$775

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 1, 2025.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Odessa

Fly to

Knoxville

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

mié. 2/18

6:00 am-11:13 am

1 stop4h 13m

Knoxville McGhee Tyson

sáb. 2/21

6:26 pm-10:16 pm

1 stop4h 50m

$387

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

mié. 10/15

4:14 pm-12:23 am

1 stop7h 09m

Knoxville McGhee Tyson

dom. 10/19

6:00 am-9:43 am

1 stop4h 43m

$500

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

mié. 2/18

11:45 am-9:07 pm

2 stops8h 22m

Knoxville McGhee Tyson

sáb. 2/21

6:45 am-4:21 pm

2 stops10h 36m

$614

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

lun. 11/3

6:57 pm-12:08 am

1 stop4h 11m

Knoxville McGhee Tyson

jue. 11/6

6:18 pm-11:55 pm

1 stop6h 37m

$649

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/29

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

What is the cheapest month to book a flight from Odessa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $296). Flying from Odessa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated octubre 1, 2025.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,929 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Entertainment

7.1

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.
United Airlines
7.4
Good
8,929 reviews
United Airlines
7.4
Good
8,929 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Entertainment

7.1

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.
American Airlines
7.2
Good
11,030 reviews
United Airlines
7.4
Good
8,929 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Entertainment

7.1

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 2 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Odessa to Knoxville?

    For as low as $387, American Airlines can have you in Knoxville from Odessa in 4h 13m. Airlines will cover a distance of 1076 mi.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $296). Flying from Odessa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Odessa to Knoxville

Discover the top 2 airlines that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$243Average$458FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$538FlexibilityNo cancel feeOn-time69%

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