How long is the flight from Odessa to Knoxville?

For as low as $416, American Airlines can have you in Knoxville from Odessa in 4h 20m. Airlines will cover a distance of 1076 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from OD3 to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Odessa to Knoxville as you normally would.

What airport do you fly into for flights to Knoxville from Odessa?

Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Odessa to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

Can I find deals for business class flights from Odessa to Knoxville?

Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$416+ Cheap Flights from Odessa to Knoxville

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Odessa to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Sun 12/77:00 amMAF - TYS

1 stop5h 49mUnited Airlines

Fri 12/124:59 pmTYS - MAF

1 stop7h 14mUnited Airlines

Deal found 11/14

$477

Sun 12/75:00 amMAF - TYS

2 stops8h 29mAmerican Airlines

Fri 12/126:00 amTYS - MAF

2 stops8h 59mAmerican Airlines

Deal found 11/14

$517

Sun 11/306:05 amMAF - TYS

1 stop4h 19mAmerican Airlines

Thu 12/44:22 pmTYS - MAF

1 stop7h 08mAmerican Airlines

Deal found 11/15

$823

Tue 11/256:05 amMAF - TYS

1 stop4h 17mAmerican Airlines

Sun 11/306:22 pmTYS - MAF

1 stop5h 16mAmerican Airlines

Deal found 11/14

$899

Wed 11/2610:15 amMAF - TYS

1 stop6h 13mAmerican Airlines

Sun 11/306:22 pmTYS - MAF

1 stop5h 16mAmerican Airlines

Deal found 11/14

$922

Wed 11/261:55 pmMAF - TYS

2 stops9h 04mUnited Airlines

Sun 11/307:20 pmTYS - MAF

2 stops27h 22mUnited Airlines

Deal found 11/14

$1,243

Best flights from Odessa to Knoxville
Discover carefully curated flight deals from Odessa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 17, 2025.

Fri 1/210:19 amMAF - TYS

1 stop4h 20mAmerican Airlines

Tue 1/64:41 pmTYS - MAF

1 stop5h 08mAmerican Airlines

Deal found 11/15

$416

Sun 12/77:00 amMAF - TYS

1 stop5h 49mUnited Airlines

Fri 12/124:59 pmTYS - MAF

1 stop7h 14mUnited Airlines

Deal found 11/14

$477

Sun 12/75:00 amMAF - TYS

2 stops8h 29mAmerican Airlines

Fri 12/126:00 amTYS - MAF

2 stops8h 59mAmerican Airlines

Deal found 11/14

$517

Sun 11/306:05 amMAF - TYS

1 stop4h 19mAmerican Airlines

Thu 12/44:22 pmTYS - MAF

1 stop7h 08mAmerican Airlines

Deal found 11/15

$823

Tue 11/256:05 amMAF - TYS

1 stop4h 17mAmerican Airlines

Sun 11/305:05 amTYS - MAF

2 stops7h 48mAmerican Airlines

Deal found 11/16

$1,109

Last-minute flights from Odessa to Knoxville
Discover last-minute flight deals from Odessa to Knoxville. Data last updated November 17, 2025 and is based on user searches.

Tue 11/256:05 amMAF - TYS

1 stop4h 17mAmerican Airlines

Sun 11/305:05 amTYS - MAF

2 stops7h 48mAmerican Airlines

Deal found 11/16

$1,109

Sun 11/306:05 amMAF - TYS

1 stop4h 19mAmerican Airlines

Thu 12/44:22 pmTYS - MAF

1 stop7h 08mAmerican Airlines

Deal found 11/15

$823

Sun 12/77:00 amMAF - TYS

1 stop5h 49mUnited Airlines

Fri 12/124:59 pmTYS - MAF

1 stop7h 14mUnited Airlines

Deal found 11/14

$477

Sun 12/75:00 amMAF - TYS

2 stops8h 29mAmerican Airlines

Fri 12/126:00 amTYS - MAF

2 stops8h 59mAmerican Airlines

Deal found 11/14

$517

Cheap flight deals from Odessa to Knoxville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$416 (American Airlines)
Popular in	March
Cheapest in	July

Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.

Search Deals

Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.

Search Deals

From Odessa to Knoxville McGhee Tyson

Search Deals

Highest demand for flights based on searches. 11% potential increase in price ($52 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Fri 1/2

10:19 am-3:39 pm

1 stop4h 20m

Knoxville McGhee Tyson

Tue 1/6

4:41 pm-8:49 pm

1 stop5h 08m

$416

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 12/7

7:00 am-1:49 pm

1 stop5h 49m

Knoxville McGhee Tyson

Fri 12/12

4:59 pm-11:13 pm

1 stop7h 14m

$477

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 12/7

5:00 am-2:29 pm

2 stops8h 29m

Knoxville McGhee Tyson

Fri 12/12

6:00 am-1:59 pm

2 stops8h 59m

$517

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 11/30

6:05 am-11:24 am

1 stop4h 19m

Knoxville McGhee Tyson

Thu 12/4

4:22 pm-10:30 pm

1 stop7h 08m

$823

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Tue 11/25

6:05 am-11:22 am

1 stop4h 17m

Knoxville McGhee Tyson

Sun 11/30

5:05 am-11:53 am

2 stops7h 48m

$1,109

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/15

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Odessa to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,050 reviews

Reviews

1 / 20

6.0

Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

American Airlines

7.2

Good

11,050 reviews

American Airlines

7.2

Good

11,050 reviews

Reviews

1 / 20

6.0

Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

What airport do you fly into for flights to Knoxville from Odessa?
Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.
How long is the flight from Odessa to Knoxville?
For as low as $416, American Airlines can have you in Knoxville from Odessa in 4h 20m. Airlines will cover a distance of 1076 mi. This flight may include one or multiple stops.
Can I find deals for flights from Odessa to Knoxville that include hotel bookings?
Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Odessa to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.
Can I find deals for business class flights from Odessa to Knoxville?
Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Morristown

Cherokee

Crossville

Corbin

Bryson City

Alcoa

Oak Ridge

Murphy

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Odessa to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$243	Average$447	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$416+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Odessa to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to KnoxvilleExplore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

Cheap flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated November 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Cheapflights Fare Finder

Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Odessa to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from Odessa?

How long is the flight from Odessa to Knoxville?

Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

How can I find direct flights from Odessa to Knoxville?

Can I find deals for business class flights from Odessa to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Odessa to Knoxville

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.