HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$334+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Mar 25 — Apr 11
Wed 3/25
Wed 4/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Odessa to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.

This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:00 am
MAF
-
TYS
1 stop4h 30m
American Airlines
Sat 4/114:09 pm
TYS
-
MAF
1 stop6h 58m
American Airlines
Deal found 2/22$334
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:16 pm
MAF
-
TYS
1 stop4h 40m
American Airlines
Fri 5/154:09 pm
TYS
-
MAF
1 stop6h 58m
American Airlines
Deal found 2/20$355
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:30 am
MAF
-
TYS
2 stops6h 25m
Southwest
Sat 4/113:55 pm
TYS
-
MAF
1 stop6h 05m
Southwest
Deal found 2/22$383
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:40 am
MAF
-
TYS
2 stops11h 57m
United Airlines
Wed 3/46:45 am
TYS
-
MAF
2 stops10h 49m
United Airlines
Deal found 2/19$473
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:50 am
MAF
-
TYS
2 stops9h 30m
Southwest
Mon 5/186:35 am
TYS
-
MAF
2 stops9h 25m
Southwest
Deal found 2/23$486
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:25 pm
MAF
-
TYS
1 stop5h 19m
United Airlines
Thu 3/127:00 am
TYS
-
MAF
2 stops10h 21m
United Airlines
Deal found 2/21$542
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:45 am
MAF
-
TYS
2 stops10h 00m
Southwest
Thu 3/123:45 pm
TYS
-
MAF
2 stops9h 35m
Southwest
Deal found 2/21$567

Find flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated February 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$334
(American Airlines)

Popular in

December

Cheapest in

July
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
Search Deals
From Odessa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 31% potential increase in price ($215 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 16% potential price decrease ($67 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Odessa

Fly to

Knoxville

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 4/5

6:00 am-11:30 am

1 stop4h 30m

Knoxville McGhee Tyson

Sat 4/11

4:09 pm-10:07 pm

1 stop6h 58m

$334

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Mon 5/11

6:16 pm-11:56 pm

1 stop4h 40m

Knoxville McGhee Tyson

Fri 5/15

4:09 pm-10:07 pm

1 stop6h 58m

$355

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 4/5

5:30 am-12:55 pm

2 stops6h 25m

Knoxville McGhee Tyson

Sat 4/11

3:55 pm-9:00 pm

1 stop6h 05m

$383

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 3/8

2:48 pm-11:44 pm

1 stop7h 56m

Knoxville McGhee Tyson

Thu 3/12

4:18 pm-10:15 pm

1 stop6h 57m

$537

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 3/8

7:45 am-6:45 pm

2 stops10h 00m

Knoxville McGhee Tyson

Thu 3/12

3:45 pm-12:20 am

2 stops9h 35m

$567

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Tue 3/10

12:23 pm-9:48 pm

2 stops8h 25m

Knoxville McGhee Tyson

Sat 3/14

6:21 pm-12:09 am

1 stop6h 48m

$574

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 3/8

5:00 am-11:30 am

1 stop5h 30m

Knoxville McGhee Tyson

Fri 3/13

12:21 pm-5:29 pm

1 stop6h 08m

$578

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Mon 5/11

7:00 pm-8:45 pm

3 stops24h 45m

Knoxville McGhee Tyson

Fri 5/15

8:45 am-4:26 pm

1 stop8h 41m

$593

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Fri 5/15

9:50 am-8:20 pm

2 stops9h 30m

Knoxville McGhee Tyson

Mon 5/18

2:45 pm-11:10 pm

1 stop9h 25m

$602

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/22

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

What is the cheapest month to book a flight from Odessa to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $243). Flying from Odessa to Knoxville in November is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 23, 2026.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,339 reviews

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
11,339 reviews
American Airlines
7.2
Good
11,339 reviews

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Odessa to Knoxville?

    For as low as $334, American Airlines can have you in Knoxville from Odessa in 4h 30m. Airlines will cover a distance of 1076 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $243). Flying from Odessa to Knoxville in November is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Nashville flights
Hobby to Nashville flights
George Bush Intcntl to Nashville flights
Austin to Nashville flights
Dallas/Fort Worth to Memphis flights
Dallas/Fort Worth to Knoxville flights
Love Field to Nashville flights
Hobby to Knoxville flights
Hobby to Memphis flights
George Bush Intcntl to Knoxville flights
San Antonio to Nashville flights
Dallas/Fort Worth to Chattanooga flights
George Bush Intcntl to Memphis flights
Austin to Knoxville flights
Love Field to Memphis flights
Love Field to Knoxville flights
Austin to Memphis flights
El Paso to Nashville flights
San Antonio to Knoxville flights
Hobby to Chattanooga flights
San Antonio to Memphis flights
Corpus Christi to Nashville flights
George Bush Intcntl to Chattanooga flights
Midland to Nashville flights
Dallas/Fort Worth to Blountville flights
El Paso to Knoxville flights
Austin to Chattanooga flights
McAllen to Nashville flights
Corpus Christi to Knoxville flights
Love Field to Chattanooga flights
San Antonio to Chattanooga flights
McAllen to Knoxville flights
Brownsville to Nashville flights
Midland to Knoxville flights
George Bush Intcntl to Blountville flights
Hobby to Blountville flights
El Paso to Chattanooga flights
Love Field to Blountville flights
Harlingen to Nashville flights
Corpus Christi to Memphis flights
Austin to Blountville flights
Tyler to Nashville flights
Lubbock to Nashville flights
Amarillo to Knoxville flights
Laredo to Nashville flights
Amarillo to Nashville flights
San Antonio to Blountville flights
Waco to Nashville flights
Killeen to Blountville flights
Amarillo to Memphis flights

Top airline flying from Odessa to Knoxville

Discover the top airline that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$243Average$447FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.