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$331+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$331
(American Airlines)

Popular in

December

Cheapest in

July

Average price

$321
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
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From Odessa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 32% potential increase in price ($227 potential increase over avg. RT price).
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Cheapest flight prices on average. 14% potential price decrease ($60 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 amMAF - TYS
1 stop6h 30mAmerican Airlines
Fri 5/151:20 pmTYS - MAF
1 stop5h 26mAmerican Airlines
Deal found 1/6$362
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/315:35 pmMAF - TYS
1 stop5h 09mUnited Airlines
Tue 2/311:10 amTYS - MAF
2 stops11h 44mUnited Airlines
Deal found 1/6$409
This Southwest deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:50 amMAF - TYS
2 stops10h 25mSouthwest
Sun 5/106:40 amTYS - MAF
2 stops10h 25mSouthwest
Deal found 1/6$423
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/21:53 pmMAF - TYS
1 stop7h 27mUnited Airlines
Sat 12/58:45 amTYS - MAF
1 stop8h 30mUnited Airlines
Deal found 1/5$427

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Odessa

Fly to

Knoxville

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sat 1/31

5:35 pm-11:44 pm

1 stop5h 09m

Knoxville McGhee Tyson

Tue 2/3

1:59 pm-9:54 pm

2 stops8h 55m

$409

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Wed 2/4

12:05 pm-7:50 pm

1 stop6h 45m

Knoxville McGhee Tyson

Sun 2/8

6:59 am-11:21 am

1 stop5h 22m

$572

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

What is the cheapest month to book a flight from Odessa to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $231). Flying from Odessa to Knoxville in November is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 7, 2026.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,088 reviews

Overall

7.2

Boarding

7.5

Entertainment

6.9

Crew

8.0

Comfort

7.2

Food

6.4

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
11,088 reviews
American Airlines
7.2
Good
11,088 reviews

Overall

7.2

Boarding

7.5

Entertainment

6.9

Crew

8.0

Comfort

7.2

Food

6.4

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Odessa to Knoxville?

    For as low as $409, United Airlines can have you in Knoxville from Odessa in 5h 09m. Airlines will cover a distance of 1076 mi.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $231). Flying from Odessa to Knoxville in November is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Odessa to Knoxville

Discover the top airline that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$243Average$447FlexibilityNo cancel feeOn-time71%

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