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Knoxville

$259+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Aug 16 — Aug 231
Sat 8/16
Sat 8/23
1 adult, Economy
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Cheap flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated August 11, 2025.

Round-trip from

$259
(American Airlines)

Popular in

October

Cheapest in

July

Average price

$378
From Odessa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($108 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
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Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2025.

This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/16:22 pmMAF - TYS
1 stop4h 28mAmerican Airlines
Sun 9/75:30 amTYS - MAF
1 stop6h 17mAmerican Airlines
Deal found 8/10$259
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/42:29 pmMAF - TYS
2 stops7h 34mAmerican Airlines
Mon 9/84:37 pmTYS - MAF
1 stop7h 27mAmerican Airlines
Deal found 8/9$264
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/52:29 pmMAF - TYS
2 stops7h 34mAmerican Airlines
Mon 9/83:09 pmTYS - MAF
2 stops8h 55mAmerican Airlines
Deal found 8/9$381
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/46:00 amMAF - TYS
2 stops13h 56mUnited Airlines
Mon 9/87:25 pmTYS - MAF
3 stops27h 30mUnited Airlines
Deal found 8/9$473
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/245:30 amMAF - TYS
2 stops9h 04mDelta
Thu 8/288:35 amTYS - MAF
2 stops9h 02mDelta
Deal found 8/9$493
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/58:00 amMAF - TYS
2 stops11h 56mUnited Airlines
Mon 9/84:40 pmTYS - MAF
3 stops30h 15mUnited Airlines
Deal found 8/9$546
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/15:30 amMAF - TYS
2 stops10h 49mDelta
Sun 9/74:19 pmTYS - MAF
2 stops8h 39mDelta
Deal found 8/11$589
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/246:00 amMAF - TYS
1 stop7h 50mUnited Airlines
Thu 8/287:20 amTYS - MAF
1 stop7h 42mUnited Airlines
Deal found 8/9$675

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2025.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Odessa

Fly to

Knoxville

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Mon 9/1

6:22 pm-11:50 pm

1 stop4h 28m

Knoxville McGhee Tyson

Sun 9/7

5:30 am-10:47 am

1 stop6h 17m

$259

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Thu 9/4

2:29 pm-11:03 pm

2 stops7h 34m

Knoxville McGhee Tyson

Mon 9/8

4:37 pm-11:04 pm

1 stop7h 27m

$264

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Fri 9/5

2:29 pm-11:03 pm

2 stops7h 34m

Knoxville McGhee Tyson

Mon 9/8

3:09 pm-11:04 pm

2 stops8h 55m

$381

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Thu 9/4

6:00 am-8:56 pm

2 stops13h 56m

Knoxville McGhee Tyson

Mon 9/8

7:25 pm-9:55 pm

3 stops27h 30m

$473

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 8/24

5:30 am-3:34 pm

2 stops9h 04m

Knoxville McGhee Tyson

Thu 8/28

8:35 am-4:37 pm

2 stops9h 02m

$493

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Fri 9/5

8:00 am-8:56 pm

2 stops11h 56m

Knoxville McGhee Tyson

Mon 9/8

4:40 pm-9:55 pm

3 stops30h 15m

$546

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Mon 9/1

5:30 am-5:19 pm

2 stops10h 49m

Knoxville McGhee Tyson

Sun 9/7

4:19 pm-11:58 pm

2 stops8h 39m

$589

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 8/24

6:00 am-2:50 pm

1 stop7h 50m

Knoxville McGhee Tyson

Thu 8/28

7:20 am-2:02 pm

1 stop7h 42m

$675

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/10

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 11, 2025.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,978 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,978 reviews
Delta
8.0
Very good
7,978 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,922 reviews
Delta
8.0
Very good
7,978 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,978 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $294). Flying from Odessa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Odessa to Knoxville

Discover the top 3 airlines that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$234Average$269FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$243Average$458FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$301Average$533FlexibilityNo cancel feeOn-time69%

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