HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$209+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Jul 1 — Jul 81
Wed 7/1
Wed 7/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Odessa to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 1, 2026.

This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:54 am
MAF
-
TYS
1 stop5h 23m
United Airlines
Wed 8/264:50 pm
TYS
-
MAF
1 stop6h 19m
United Airlines
Deal found 5/27$421
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:40 pm
MAF
-
TYS
2 stops5h 30m
Southwest
Mon 7/66:40 am
TYS
-
MAF
2 stops8h 15m
Southwest
Deal found 5/29$545
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/148:30 am
MAF
-
TYS
1 stop7h 13m
American Airlines
Fri 6/195:33 pm
TYS
-
MAF
1 stop7h 26m
American Airlines
Deal found 5/30$557
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:05 am
MAF
-
TYS
1 stop5h 05m
Southwest
Fri 6/196:40 am
TYS
-
MAF
2 stops7h 15m
Southwest
Deal found 5/30$602
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:05 am
MAF
-
TYS
1 stop12h 05m
Southwest
Mon 6/156:40 am
TYS
-
MAF
2 stops7h 15m
Southwest
Deal found 5/27$623

Find flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated June 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$421
(United Airlines)
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
Search Deals
From Odessa to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 1, 2026.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Tue 8/25

11:54 am-6:17 pm

1 stop5h 23m

Knoxville McGhee Tyson

Wed 8/26

4:50 pm-10:09 pm

1 stop6h 19m

$421
Cheapest one-way
Quickest one-way

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 7/5

5:13 pm-11:12 pm

1 stop4h 59m

$209

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 7/5

9:55 am-9:20 pm

2 stops10h 25m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/31

Sorted by cheapest first

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 0 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Odessa to Knoxville?

    For as low as $421, United Airlines can have you in Knoxville from Odessa in 5h 23m. Airlines will cover a distance of 1076 mi.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Odessa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Nashville flights
Hobby to Nashville flights
George Bush Intcntl to Nashville flights
Austin to Nashville flights
Dallas/Fort Worth to Memphis flights
Dallas/Fort Worth to Knoxville flights
George Bush Intcntl to Knoxville flights
Hobby to Knoxville flights
Love Field to Nashville flights
Hobby to Memphis flights
San Antonio to Nashville flights
George Bush Intcntl to Memphis flights
Love Field to Knoxville flights
Hobby to Chattanooga flights
Dallas/Fort Worth to Chattanooga flights
Love Field to Memphis flights
George Bush Intcntl to Chattanooga flights
Austin to Memphis flights
San Antonio to Knoxville flights
Austin to Knoxville flights
Dallas/Fort Worth to Blountville flights
El Paso to Nashville flights
Hobby to Blountville flights
San Antonio to Memphis flights
El Paso to Knoxville flights
Corpus Christi to Nashville flights
Austin to Chattanooga flights
San Antonio to Blountville flights
Corpus Christi to Knoxville flights
Brownsville to Nashville flights
McAllen to Knoxville flights
San Antonio to Chattanooga flights
Harlingen to Nashville flights
McAllen to Nashville flights
Austin to Blountville flights
Amarillo to Nashville flights
Midland to Nashville flights
Lubbock to Nashville flights
Laredo to Nashville flights
Killeen to Nashville flights
Amarillo to Knoxville flights
Amarillo to Memphis flights
Love Field to Chattanooga flights
Corpus Christi to Memphis flights
Tyler to Nashville flights
Midland to Knoxville flights
Longview to Knoxville flights
College Station to Nashville flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights