$200+ Cheap flights from Odessa, TX to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Oct 10 — Oct 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Odessa to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Odessa to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Odessa to KnoxvilleExplore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:10 am -
2 stops8h 45m
Tue 10/205:15 pm -
2 stops6h 40m
Deal found 9/9![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:13 pm -
1 stop6h 42m
Tue 10/275:05 pm -
1 stop6h 10m
Deal found 9/7![United Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:55 am -
2 stops6h 00m
Tue 10/273:20 pm -
2 stops7h 50m
Deal found 9/7![Southwest logo]()
$409
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:15 am -
2 stops9h 40m
Mon 10/265:30 pm -
1 stop5h 50m
Deal found 9/7![Southwest logo]()
$514
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:50 am -
1 stop7h 15m
Sat 1/21:55 pm -
1 stop10h 10m
Deal found 9/7![Southwest logo]()
$631
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:55 am -
2 stops8h 15m
Sun 9/2711:35 am -
1 stop7h 10m
Deal found 9/7![Southwest logo]()
$1,153
Best flights from Odessa to KnoxvilleDiscover carefully curated flight deals from Odessa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Odessa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:10 am -
2 stops8h 45m
Tue 10/205:15 pm -
2 stops6h 40m
Deal found 9/9![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:34 am -
2 stops10h 27m
Tue 10/275:05 pm -
1 stop6h 10m
Deal found 9/7![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/305:00 am -
1 stop5h 02m
Wed 2/35:20 pm -
1 stop7h 17m
Deal found 9/9![United Airlines logo]()
$423
Last-minute flights from Odessa to KnoxvilleDiscover last-minute flight deals from Odessa to Knoxville. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to Knoxville. Data last updated September 10, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:55 am -
2 stops8h 15m
Sun 9/2711:35 am -
1 stop7h 10m
Deal found 9/7![Southwest logo]()
$1,153
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:00 am -
1 stop27h 17m
Sun 9/276:00 am -
2 stops18h 27m
Deal found 9/7![United Airlines logo]()
$1,399
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:20 pm -
1 stop15h 57m
Sun 9/276:00 am -
1 stop4h 45m
Deal found 9/7![American Airlines logo]()
$1,409
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:10 am -
2 stops8h 45m
Tue 10/205:15 pm -
2 stops6h 40m
Deal found 9/9![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:13 pm -
1 stop6h 42m
Tue 10/275:05 pm -
1 stop6h 10m
Deal found 9/7![United Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:55 am -
2 stops6h 00m
Tue 10/273:20 pm -
2 stops7h 50m
Deal found 9/7![Southwest logo]()
$409
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:15 am -
2 stops9h 40m
Mon 10/265:30 pm -
1 stop5h 50m
Deal found 9/7![Southwest logo]()
$514
One-way flights from Odessa to KnoxvilleSearch for one-way flight options from Odessa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Odessa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:31 am -
1 stop5h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$200
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:05 pm -
2 stops7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$205
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am -
1 stop6h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:54 am -
2 stops11h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:30 am -
3 stops12h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$1,304
Find flight deals from Odessa to Knoxville
Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $388 (Southwest) |
One-way from | $200 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MidlandKnoxville
MAF Midland Intl - TYS Knoxville McGhee Tyson
MAFTYS
Midland Intl
Mon 10/5
2:05 pm-10:45 pm
2 stops7h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$205
MidlandKnoxville
MAF Midland Intl - TYS Knoxville McGhee Tyson
MAFTYS
Midland Intl
Sat 10/17
8:10 am-5:55 pm
2 stops8h 45m
Knoxville McGhee Tyson
Tue 10/20
5:15 pm-10:55 pm
2 stops6h 40m
$388
MidlandKnoxville
MAF Midland Intl - TYS Knoxville McGhee Tyson
MAFTYS
Midland Intl
Tue 9/15
11:54 am-12:23 am
2 stops11h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$399
MidlandKnoxville
MAF Midland Intl - TYS Knoxville McGhee Tyson
MAFTYS
Midland Intl
Sat 10/24
9:34 am-9:01 pm
2 stops10h 27m
Knoxville McGhee Tyson
Tue 10/27
5:05 pm-10:15 pm
1 stop6h 10m
$404
MidlandKnoxville
MAF Midland Intl - TYS Knoxville McGhee Tyson
MAFTYS
Midland Intl
Sat 1/30
5:00 am-11:02 am
1 stop5h 02m
Knoxville McGhee Tyson
Wed 2/3
5:20 pm-11:37 pm
1 stop7h 17m
$423
Sorted by cheapest first
Best time to book a flight from Odessa to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
MAF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to Knoxville
OD3-TYS
MAF-TYS
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Popular flights
Top destinations