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$376+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
May 12 — May 191
Tue 5/12
Tue 5/19
1 adult, Economy
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Cheap flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 12, 2026.

This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:00 am
MAF
-
TYS
1 stop6h 30m
American Airlines
Fri 5/156:54 pm
TYS
-
MAF
1 stop6h 12m
American Airlines
Deal found 4/8$376
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/138:25 am
MAF
-
TYS
2 stops7h 45m
Southwest
Thu 5/212:45 pm
TYS
-
MAF
2 stops9h 40m
Southwest
Deal found 4/7$384
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:45 pm
MAF
-
TYS
1 stop7h 38m
United Airlines
Wed 5/64:20 pm
TYS
-
MAF
1 stop6h 55m
United Airlines
Deal found 4/7$401
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:20 am
MAF
-
TYS
1 stop6h 46m
United Airlines
Wed 4/294:30 pm
TYS
-
MAF
1 stop6h 45m
United Airlines
Deal found 4/10$443
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:10 am
MAF
-
TYS
2 stops9h 20m
Southwest
Wed 4/297:05 am
TYS
-
MAF
2 stops8h 35m
Southwest
Deal found 4/10$453

Find flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated April 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$376
(American Airlines)
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
Search Deals
From Odessa to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Mon 5/11

5:00 am-12:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Fri 5/15

6:54 pm-12:06 am

1 stop6h 12m

$376

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Wed 5/13

8:25 am-5:10 pm

2 stops7h 45m

Knoxville McGhee Tyson

Thu 5/21

2:45 pm-11:25 pm

2 stops9h 40m

$384
Quickest round-trip

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Tue 5/5

7:00 am-1:34 pm

1 stop5h 34m

Knoxville McGhee Tyson

Wed 5/6

4:20 pm-10:15 pm

1 stop6h 55m

$401

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sat 4/25

8:10 am-6:30 pm

2 stops9h 20m

Knoxville McGhee Tyson

Wed 4/29

7:05 am-2:40 pm

2 stops8h 35m

$453

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/7

Sorted by cheapest first

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 12, 2026.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,570 reviews

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.1

Comfort

7.2

Crew

7.9

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.1
Good
11,570 reviews
American Airlines
7.1
Good
11,570 reviews

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.1

Comfort

7.2

Crew

7.9

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 1 airline. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Odessa to Knoxville?

    For as low as $401, American Airlines can have you in Knoxville from Odessa in 5h 34m. Airlines will cover a distance of 1076 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Odessa to Knoxville

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Top airline flying from Odessa to Knoxville

Discover the top airline that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$243Average$523FlexibilityNo cancel feeOn-time71%

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