HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$228+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Columbia to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Columbia to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$228
(United Airlines)
Provider with most accurate pricing for Columbia Regional-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Knoxville McGhee Tyson flights.
Search Deals
From Columbia Regional to Knoxville McGhee Tyson
Search Deals

Find flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:02 pmCOU - TYS
1 stop6h 53mUnited Airlines
Sat 11/158:26 amTYS - COU
1 stop7h 00mUnited Airlines
Deal found 10/26$228
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:02 pmCOU - TYS
1 stop6h 53mUnited Airlines
Sat 11/18:26 amTYS - COU
1 stop7h 00mUnited Airlines
Deal found 10/26$288
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:37 pmCOU - TYS
1 stop16h 06mAmerican Airlines
Mon 11/172:59 pmTYS - COU
1 stop7h 56mAmerican Airlines
Deal found 10/24$357
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:02 pmCOU - TYS
2 stops7h 57mUnited Airlines
Mon 11/178:26 amTYS - COU
1 stop7h 00mUnited Airlines
Deal found 10/24$502
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:32 amCOU - TYS
1 stop10h 10mAmerican Airlines
Sun 11/309:56 pmTYS - COU
1 stop16h 39mAmerican Airlines
Deal found 10/26$602
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:02 pmCOU - TYS
1 stop6h 53mUnited Airlines
Sat 11/2910:50 amTYS - COU
1 stop4h 36mUnited Airlines
Deal found 10/26$783

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Columbia

Fly to

Knoxville

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 11/11

3:02 pm-10:55 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 11/15

8:26 am-2:26 pm

1 stop7h 00m

$228

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 10/30

3:02 pm-10:55 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 11/1

8:26 am-2:26 pm

1 stop7h 00m

$288

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 11/14

7:37 pm-12:43 pm

1 stop16h 06m

Knoxville McGhee Tyson

Mon 11/17

2:59 pm-9:55 pm

1 stop7h 56m

$357

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 11/14

3:02 pm-11:59 pm

2 stops7h 57m

Knoxville McGhee Tyson

Mon 11/17

8:26 am-2:26 pm

1 stop7h 00m

$502

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 11/27

6:32 am-5:42 pm

1 stop10h 10m

Knoxville McGhee Tyson

Sun 11/30

9:56 pm-1:35 pm

1 stop16h 39m

$602

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 11/26

3:02 pm-10:55 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 11/29

10:50 am-2:26 pm

1 stop4h 36m

$783

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Compare providers for flights from Columbia to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 27, 2025.
See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,033 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Food

6.4

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,033 reviews
American Airlines
7.2
Good
11,033 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Food

6.4

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to Knoxville?

    For as low as $228, United Airlines can have you in Knoxville from Columbia, Missouri in 6h 53m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi.

  • What is the cheapest airline to fly from Columbia, Missouri to Knoxville round-trip?

    Our cheapest airline available from Columbia, Missouri to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $430 on this airline.

  • Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

  • Can I find deals for business class flights from Columbia to Knoxville?

    Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Columbia to Knoxville

Discover the top airline that operate flights from Columbia to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$430Average$539FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.