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$410+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Columbia to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$410
(American Airlines)
From Columbia Regional to Knoxville McGhee Tyson
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Find flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/211:49 pmCOU - TYS
1 stop6h 14mAmerican Airlines
Sat 10/257:05 amTYS - COU
1 stop5h 40mAmerican Airlines
Deal found 9/10$410
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/134:23 pmCOU - TYS
1 stop4h 53mAmerican Airlines
Tue 9/164:49 pmTYS - COU
1 stop4h 32mAmerican Airlines
Deal found 9/10$430
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:25 pmCOU - TYS
1 stop5h 58mAmerican Airlines
Fri 10/243:03 pmTYS - COU
1 stop7h 28mAmerican Airlines
Deal found 9/9$464
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:34 amCOU - TYS
2 stops8h 13mAmerican Airlines
Mon 11/175:10 amTYS - COU
2 stops9h 25mAmerican Airlines
Deal found 9/8$475
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/131:36 pmCOU - TYS
1 stop6h 24mAmerican Airlines
Mon 9/1512:51 pmTYS - COU
1 stop4h 53mAmerican Airlines
Deal found 9/10$498
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:05 amCOU - TYS
1 stop25h 12mUnited Airlines
Fri 12/265:35 pmTYS - COU
1 stop22h 00mUnited Airlines
Deal found 9/10$507

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Columbia

Fly to

Knoxville

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 10/21

1:49 pm-9:03 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 10/25

7:05 am-11:45 am

1 stop5h 40m

$410

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 10/15

5:25 pm-12:23 am

1 stop5h 58m

Knoxville McGhee Tyson

Fri 10/24

3:03 pm-9:31 pm

1 stop7h 28m

$464

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 11/15

7:09 am-3:35 pm

1 stop7h 26m

Knoxville McGhee Tyson

Mon 11/17

7:54 am-1:35 pm

1 stop6h 41m

$464

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 9/24

4:23 pm-12:21 am

1 stop6h 58m

Knoxville McGhee Tyson

Sun 9/28

7:14 am-1:06 pm

1 stop6h 52m

$498

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 12/19

8:05 am-10:17 am

1 stop25h 12m

Knoxville McGhee Tyson

Fri 12/26

5:35 pm-2:35 pm

1 stop22h 00m

$507

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 9/25

4:23 pm-11:51 pm

1 stop6h 28m

Knoxville McGhee Tyson

Sun 10/5

7:14 am-1:06 pm

1 stop6h 52m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.4

Overall

7.2

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.4

Overall

7.2

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to Knoxville?

    For as low as $410, American Airlines can have you in Knoxville from Columbia, Missouri in 6h 14m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi.

  • What is the cheapest airline to fly from Columbia, Missouri to Knoxville round-trip?

    Our cheapest airline available from Columbia, Missouri to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $434 on this airline.

  • Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

  • Can I find deals for business class flights from Columbia to Knoxville?

    Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to Knoxville (average of $294). Flying from Columbia, Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Columbia to Knoxville

Discover the top airline that operate flights from Columbia to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$434Average$609FlexibilityNo cancel feeOn-time71%

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