How long is the flight from Columbia, Missouri to Knoxville?

For as low as $238, United Airlines can have you in Knoxville from Columbia, Missouri in 4h 42m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from COU to TYS?

When flying from Columbia, Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbia to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

Can I find deals for business class flights from Columbia to Knoxville?

Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$238+ Flights from Columbia, MO to Knoxville

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1. Tell us where you want to go

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2. Select your favorite providers

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Cheap flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Fri 12/266:34 pmCOU - TYS

2 stops28h 25mUnited Airlines

Tue 12/305:45 amTYS - COU

2 stops9h 50mUnited Airlines

Deal found 12/10

$458

Fri 12/2610:09 amCOU - TYS

1 stop4h 47mAmerican Airlines

Tue 12/3011:21 amTYS - COU

1 stop4h 28mAmerican Airlines

Deal found 12/10

$509

Best flights from Columbia to Knoxville
Discover carefully curated flight deals from Columbia to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Sat 1/243:10 pmCOU - TYS

1 stop4h 42mUnited Airlines

Sun 1/256:45 amTYS - COU

1 stop4h 57mUnited Airlines

Deal found 12/10

$238

Sat 1/246:00 amCOU - TYS

2 stops11h 46mAmerican Airlines

Sun 1/2511:33 amTYS - COU

2 stops10h 37mAmerican Airlines

Deal found 12/10

$436

Sat 1/243:10 pmCOU - TYS

1 stop4h 42mUnited Airlines

Wed 1/2811:10 amTYS - COU

1 stop4h 25mUnited Airlines

Deal found 12/9

$278

Last-minute flights from Columbia to Knoxville
Discover last-minute flight deals from Columbia to Knoxville. Data last updated December 12, 2025 and is based on user searches.

Fri 12/266:34 pmCOU - TYS

2 stops28h 25mUnited Airlines

Tue 12/305:45 amTYS - COU

2 stops9h 50mUnited Airlines

Deal found 12/10

$458

Fri 12/2610:09 amCOU - TYS

1 stop4h 47mAmerican Airlines

Tue 12/3011:21 amTYS - COU

1 stop4h 28mAmerican Airlines

Deal found 12/10

$509

Sat 1/243:10 pmCOU - TYS

1 stop4h 42mUnited Airlines

Sun 1/256:45 amTYS - COU

1 stop4h 57mUnited Airlines

Deal found 12/10

$238

Sat 1/243:10 pmCOU - TYS

1 stop4h 42mUnited Airlines

Wed 1/2811:10 amTYS - COU

1 stop4h 25mUnited Airlines

Deal found 12/9

$278

Sat 1/246:00 amCOU - TYS

2 stops11h 46mAmerican Airlines

Sun 1/2511:33 amTYS - COU

2 stops10h 37mAmerican Airlines

Deal found 12/10

$436

One-way flights from Columbia to Knoxville
Search for one-way flight options from Columbia to Knoxville. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Sat 12/207:35 amCOU - TYS

1 stop7h 16mAmerican Airlines

Deal found 12/10

$398

Find flight deals from Columbia to Knoxville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$238 (United Airlines)

Provider with most accurate pricing for Columbia Regional-Knoxville McGhee Tyson flight deals.

Search Deals

Provider most trusted by Cheapflights users for Columbia Regional-Knoxville McGhee Tyson flights.

Search Deals

From Columbia Regional to Knoxville McGhee Tyson

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 1/24

3:10 pm-8:52 pm

1 stop4h 42m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-10:42 am

1 stop4h 57m

$238

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 1/24

3:10 pm-8:52 pm

1 stop4h 42m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-2:35 pm

1 stop4h 25m

$278

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 1/24

6:00 am-6:46 pm

2 stops11h 46m

Knoxville McGhee Tyson

Sun 1/25

11:33 am-9:10 pm

2 stops10h 37m

$436

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 12/20

7:35 am-3:51 pm

1 stop7h 16m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Columbia to Knoxville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,050 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

American Airlines

7.2

Good

11,050 reviews

American Airlines

7.2

Good

11,050 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

How long is the flight from Columbia, Missouri to Knoxville?
For as low as $238, United Airlines can have you in Knoxville from Columbia, Missouri in 4h 42m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi.
Can I find deals for flights from Columbia to Knoxville that include hotel bookings?
Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbia to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.
Can I find deals for business class flights from Columbia to Knoxville?
Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Cherokee

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Corbin

Morristown

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Murphy

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Other flights to Knoxville

Top airline flying from Columbia to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$430	Average$567	FlexibilityNo cancel fee	On-time71%

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$238+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbia to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Columbia to Knoxville

Cheapest flights from Columbia to KnoxvilleExplore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from Columbia to Knoxville

Most accurate provider

Most trusted provider

Round-trip from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Compare providers for flights from Columbia to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in December.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.

Reviews of airlines servicing Knoxville

See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Columbia, Missouri to Knoxville?

Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

How can I find direct flights from Columbia to Knoxville?

Can I find deals for business class flights from Columbia to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbia to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Columbia to Knoxville

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Book with Flexibility

Travel Smart

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.