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Key West

$95+ Cheap flights from South Carolina to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from South Carolina to Key West

Cheapest flights from South Carolina to Key West
Explore the most affordable flight options available from South Carolina to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:23 pmCHS - EYW
1 stop12h 44mBreeze Airways
Mon 11/38:55 amEYW - CHS
1 stop23h 42mBreeze Airways
Deal found 10/27$143
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:23 pmCHS - EYW
1 stop13h 42mBreeze Airways
Wed 11/1210:47 amEYW - CHS
1 stop3h 42mBreeze Airways
Deal found 10/27$165
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:23 pmCHS - EYW
1 stop12h 44mBreeze Airways
Mon 11/178:55 amEYW - CHS
1 stop23h 42mBreeze Airways
Deal found 10/27$187
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/159:23 pmCHS - EYW
1 stop13h 42mBreeze Airways
Thu 12/188:55 amEYW - CHS
1 stop24h 02mBreeze Airways
Deal found 10/27$198
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:17 pmGSP - EYW
1 stop16h 00mBreeze Airways
Fri 12/128:55 amEYW - GSP
1 stop10h 28mBreeze Airways
Deal found 10/27$202
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:01 pmCHS - EYW
1 stop18h 06mBreeze Airways
Sat 11/1510:47 amEYW - CHS
1 stop3h 42mBreeze Airways
Deal found 10/27$208
This Breeze Airways deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/44:01 pmCHS - EYW
1 stop18h 06mBreeze Airways
Sat 11/810:47 amEYW - CHS
1 stop3h 42mBreeze Airways
Deal found 10/29$215
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2811:56 amCLT - EYW
1 stop26h 55mMultiple Airlines
Fri 12/53:54 pmEYW - CLT
2 stops23h 33mMultiple Airlines
Deal found 10/29$216
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:59 pmCHS - EYW
1 stop17h 16mBreeze Airways
Mon 11/248:55 amEYW - CHS
1 stop23h 42mBreeze Airways
Deal found 10/27$217
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:10 pmCHS - EYW
1 stop14h 09mBreeze Airways
Sat 11/1510:47 amEYW - CHS
1 stop3h 42mBreeze Airways
Deal found 10/27$221
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/79:34 amCLT - EYW
1 stop24h 33mMultiple Airlines
Fri 11/149:57 amEYW - CLT
1 stop22h 42mMultiple Airlines
Deal found 10/28$222
This Breeze Airways deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:53 pmCHS - EYW
1 stop12h 24mBreeze Airways
Mon 11/179:57 amEYW - CHS
1 stop4h 27mBreeze Airways
Deal found 10/27$223

Cheap flight deals from South Carolina to Key West

Keep the following information in mind while searching for South Carolina to Key West flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$165
(Kiwi.com)

One-way from

$95
(Priceline)

Popular in

March

Cheapest in

November

Average price

$477
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From South Carolina to Key West
Search Deals
One-way flight from South Carolina to Key West
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($89 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

South Carolina

Fly to

Key West

Route

Depart

Return

Price

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Mon 11/10

9:23 pm-11:05 am

1 stop13h 42m

Key West

Wed 11/12

10:47 am-2:29 pm

1 stop3h 42m

$165

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Fri 11/14

9:23 pm-10:07 am

1 stop12h 44m

Key West

Mon 11/17

8:55 am-8:37 am

1 stop23h 42m

$187

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Mon 12/15

9:23 pm-11:05 am

1 stop13h 42m

Key West

Thu 12/18

8:55 am-8:57 am

1 stop24h 02m

$198

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sun 12/7

5:17 pm-9:17 am

1 stop16h 00m

Key West

Fri 12/12

8:55 am-7:23 pm

1 stop10h 28m

$202

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 11/11

4:01 pm-10:07 am

1 stop18h 06m

Key West

Sat 11/15

10:47 am-2:29 pm

1 stop3h 42m

$208

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 11/4

4:01 pm-10:07 am

1 stop18h 06m

Key West

Sat 11/8

10:47 am-2:29 pm

1 stop3h 42m

$215

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sun 1/25

5:45 am-1:30 pm

1 stop7h 45m

Key West

Fri 1/30

2:25 pm-8:41 pm

1 stop6h 16m

$217

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 11/20

2:59 pm-8:15 am

1 stop17h 16m

Key West

Mon 11/24

8:55 am-8:37 am

1 stop23h 42m

$217

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 11/12

8:10 pm-10:19 am

1 stop14h 09m

Key West

Sat 11/15

10:47 am-2:29 pm

1 stop3h 42m

$221

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 11/13

8:53 pm-9:17 am

1 stop12h 24m

Key West

Mon 11/17

9:57 am-2:24 pm

1 stop4h 27m

$223

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Key West

What is the cheapest month to book a flight from South Carolina to Key West?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EYW?

Find hourly flight availability from South Carolina to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

When flying from South Carolina to Key West, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 13% versus a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from South Carolina?

    For a flight from South Carolina to Key West, you will be flying into Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from South Carolina to Key West?

    For as low as $249, Breeze Airways can have you in Key West from South Carolina in 4h 06m. There are 653 mi between South Carolina and Key West. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Key West one-way?

    $95 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Breeze Airways and American Airlines, with prices starting from $106 and $126, respectively.

  • What are the most popular routes from South Carolina to Key West?

    When deciding which route to take from South Carolina to Key West consider Charlotte Douglas - Key West, Charleston - Key West or Myrtle Beach Intl - Key West as they are the most popular.

  • Can I find deals for flights from South Carolina to Key West that include hotel bookings?

    Yes. In addition to deals on South Carolina to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Key West.

  • Can I find deals for business class flights from South Carolina to Key West?

    Yes. Cheapflights offers flight deals from South Carolina to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Key West?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Key West

Discover the top 3 airlines that operate flights from South Carolina to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$110Average$220FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$223Average$458FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$486FlexibilityNo cancel feeOn-time71%

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