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Key West

$85+ Cheap flights from South Carolina to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
ene. 14 — ene. 211
mié. 1/14
mié. 1/21
1 adult, Economy
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Cheap flight deals from South Carolina to Key West

Cheapest flights from South Carolina to Key West
Explore the most affordable flight options available from South Carolina to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.

This Breeze Airways deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/234:43 pmGSP - EYW
1 stop14h 24mBreeze Airways
dom. 12/2810:59 amEYW - GSP
1 stop10h 15mBreeze Airways
Deal found 12/12$220
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/178:10 pmCHS - EYW
1 stop14h 09mBreeze Airways
dom. 12/218:55 amEYW - CHS
1 stop24h 02mBreeze Airways
Deal found 12/13$257
This Breeze Airways deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/188:53 pmCHS - EYW
1 stop12h 24mBreeze Airways
dom. 12/218:55 amEYW - CHS
1 stop24h 02mBreeze Airways
Deal found 12/14$263
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/319:15 amSAV - EYW
1 stop4h 15mMultiple Airlines
dom. 1/410:37 pmEYW - SAV
2 stops23h 07mMultiple Airlines
Deal found 12/15$270
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/249:34 pmCLT - EYW
1 stop10h 41mMultiple Airlines
lun. 12/292:30 pmEYW - CLT
1 stop6h 03mMultiple Airlines
Deal found 12/15$272
This Breeze Airways deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/185:17 pmGSP - EYW
1 stop16h 00mBreeze Airways
mar. 12/2310:59 amEYW - GSP
1 stop9h 41mBreeze Airways
Deal found 12/13$278
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/234:43 pmGSP - EYW
1 stop14h 24mMultiple Airlines
dom. 12/2810:37 pmEYW - GSP
2 stops19h 58mMultiple Airlines
Deal found 12/12$279
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/209:34 pmCLT - EYW
1 stop10h 41mMultiple Airlines
jue. 12/258:55 amEYW - CLT
1 stop11h 44mMultiple Airlines
Deal found 12/14$284
This Breeze Airways deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/199:23 pmCHS - EYW
1 stop9h 44mBreeze Airways
lun. 12/221:10 pmEYW - CHS
1 stop19h 27mBreeze Airways
Deal found 12/14$285
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/249:34 pmCLT - EYW
1 stop10h 41mMultiple Airlines
dom. 12/2810:37 pmEYW - CLT
2 stops21h 56mMultiple Airlines
Deal found 12/15$288
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/1910:04 pmGSP - EYW
1 stop9h 03mMultiple Airlines
dom. 12/2110:27 pmEYW - GSP
1 stop22h 47mMultiple Airlines
Deal found 12/15$294
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/219:34 pmCLT - EYW
1 stop14h 56mMultiple Airlines
jue. 12/258:55 amEYW - CLT
1 stop4h 32mMultiple Airlines
Deal found 12/13$301

Find flight deals from South Carolina to Key West

Keep the following information in mind while searching for South Carolina to Key West flight deals. Data was last updated diciembre 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$145
(Mytrip)

One-way from

$85
(Priceline)

Popular in

March

Cheapest in

September

Average price

$538
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From South Carolina to Key West
Search Deals
One-way flight from South Carolina to Key West
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

South Carolina

Fly to

Key West

Route

Depart

Return

Price

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

jue. 1/22

8:59 pm-9:09 am

1 stop12h 10m

Key West

lun. 1/26

1:06 pm-8:38 am

1 stop19h 32m

$160

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

vie. 2/6

6:00 am-1:30 pm

1 stop7h 30m

Key West

dom. 2/8

12:51 pm-6:48 pm

1 stop5h 57m

$169

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

dom. 2/8

4:13 pm-12:26 pm

1 stop20h 13m

Key West

jue. 2/12

9:46 am-2:43 pm

1 stop4h 57m

$181

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

dom. 2/22

8:59 pm-9:09 am

1 stop12h 10m

Key West

vie. 2/27

9:49 am-9:53 pm

1 stop12h 04m

$186

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

vie. 1/23

8:28 pm-10:09 am

1 stop13h 41m

Key West

dom. 1/25

10:06 am-8:43 am

1 stop22h 37m

$189

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

jue. 2/5

8:59 pm-9:09 am

1 stop12h 10m

Key West

dom. 2/8

9:46 am-8:43 am

1 stop22h 57m

$198

ColumbiaKey West

CAE - EYW

CAEEYW

Columbia Metropolitan

jue. 1/15

6:28 pm-1:30 pm

1 stop19h 02m

Key West

dom. 1/18

12:51 pm-5:38 pm

1 stop4h 47m

$202

SavannahKey West

SAV - EYW

SAVEYW

Savannah/Hilton Head

lun. 1/12

7:00 am-1:30 pm

1 stop6h 30m

Key West

lun. 1/19

2:25 pm-11:25 pm

1 stop9h 00m

$205

SavannahKey West

SAV - EYW

SAVEYW

Savannah/Hilton Head

vie. 1/9

7:00 am-1:30 pm

1 stop6h 30m

Key West

dom. 1/11

12:51 pm-5:05 pm

1 stop4h 14m

$205

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

mié. 1/28

12:05 pm-6:01 pm

1 stop5h 56m

Key West

mié. 2/4

1:33 pm-8:54 pm

2 stops7h 21m

$214

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Key West

What is the cheapest month to book a flight from South Carolina to Key West?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EYW?

Find hourly flight availability from South Carolina to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 15, 2025.

When flying from South Carolina to Key West, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 13% versus a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from South Carolina?

    For a flight from South Carolina to Key West, you will be flying into Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from South Carolina to Key West?

    For as low as $214, Breeze Airways can have you in Key West from South Carolina in 5h 56m. There are 653 mi between South Carolina and Key West. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Key West?

    When deciding which route to take from South Carolina to Key West consider Charlotte Douglas - Key West, Charleston - Key West or Myrtle Beach Intl - Key West as they are the most popular.

  • Can I find deals for flights from South Carolina to Key West that include hotel bookings?

    Yes. In addition to deals on South Carolina to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Key West.

  • Can I find deals for business class flights from South Carolina to Key West?

    Yes. Cheapflights offers flight deals from South Carolina to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Key West?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Key West

Discover the top 3 airlines that operate flights from South Carolina to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$110Average$220FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$223Average$455FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$469FlexibilityNo cancel feeOn-time71%

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