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Key West

$66+ Cheap flights from South Carolina to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from South Carolina to Key West

Cheapest flights from South Carolina to Key West
Explore the most affordable flight options available from South Carolina to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Breeze Airways deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:01 pm
CHS
-
EYW
1 stop21h 25m
Breeze Airways
Fri 2/279:49 am
EYW
-
CHS
1 stop12h 04m
Breeze Airways
Deal found 1/27$168
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:16 pm
CHS
-
EYW
1 stop17h 05m
Breeze Airways
Fri 2/209:49 am
EYW
-
CHS
1 stop12h 04m
Breeze Airways
Deal found 1/27$170
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:07 pm
CLT
-
EYW
1 stop21h 19m
Multiple Airlines
Thu 2/269:46 am
EYW
-
CLT
1 stop5h 43m
Multiple Airlines
Deal found 1/28$174
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/79:23 pm
CLT
-
EYW
1 stop10h 43m
Multiple Airlines
Wed 3/1111:51 am
EYW
-
CLT
1 stop20h 12m
Multiple Airlines
Deal found 1/27$181
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:01 pm
CHS
-
EYW
1 stop21h 25m
Breeze Airways
Mon 3/91:06 pm
EYW
-
CHS
1 stop19h 32m
Breeze Airways
Deal found 1/28$187
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/79:23 pm
CLT
-
EYW
1 stop17h 01m
Multiple Airlines
Thu 3/129:46 am
EYW
-
CLT
1 stop22h 12m
Multiple Airlines
Deal found 1/27$189
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:16 pm
CHS
-
EYW
1 stop22h 26m
Breeze Airways
Mon 3/91:06 pm
EYW
-
CHS
1 stop19h 32m
Breeze Airways
Deal found 1/27$190
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:46 pm
CLT
-
EYW
1 stop24h 37m
Multiple Airlines
Wed 3/412:40 pm
EYW
-
CLT
2 stops19h 46m
Multiple Airlines
Deal found 1/28$192
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:55 am
CLT
-
EYW
1 stop7h 35m
Spirit Airlines
Mon 3/92:25 pm
EYW
-
CLT
1 stop9h 31m
Spirit Airlines
Deal found 1/27$195
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/319:59 pm
CLT
-
EYW
1 stop11h 27m
Multiple Airlines
Fri 2/61:06 pm
EYW
-
CLT
1 stop5h 01m
Multiple Airlines
Deal found 1/27$202
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:01 pm
CHS
-
EYW
1 stop21h 25m
Multiple Airlines
Fri 2/271:06 pm
EYW
-
CHS
2 stops26h 59m
Multiple Airlines
Deal found 1/27$203
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:55 am
CLT
-
EYW
1 stop7h 35m
Multiple Airlines
Thu 3/129:46 am
EYW
-
CLT
1 stop22h 12m
Multiple Airlines
Deal found 1/27$203

Find flight deals from South Carolina to Key West

Keep the following information in mind while searching for South Carolina to Key West flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$168
(Breeze Airways)

One-way from

$66
(Orbitz)

Popular in

February

Cheapest in

September

Average price

$499
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From South Carolina to Key West
Search Deals
One-way flight from South Carolina to Key West
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($84 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

South Carolina

Fly to

Key West

Route

Depart

Return

Price

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sun 2/22

3:01 pm-12:26 pm

1 stop21h 25m

Key West

Fri 2/27

9:49 am-9:53 pm

1 stop12h 04m

$168

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sun 2/22

3:07 pm-12:26 pm

1 stop21h 19m

Key West

Thu 2/26

9:46 am-3:29 pm

1 stop5h 43m

$174

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 3/24

3:01 pm-11:11 am

1 stop20h 10m

Key West

Fri 3/27

9:49 am-9:53 pm

1 stop12h 04m

$211

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 2/14

5:49 pm-9:06 am

1 stop15h 17m

Key West

Tue 2/17

1:01 pm-8:26 am

2 stops19h 25m

$218

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 3/21

2:45 pm-9:06 am

1 stop18h 21m

Key West

Wed 3/25

12:40 pm-9:16 am

1 stop20h 36m

$218

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 3/4

5:00 pm-9:06 am

2 stops16h 06m

Key West

Mon 3/9

1:06 pm-8:38 am

1 stop19h 32m

$223

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 2/25

5:00 pm-9:06 am

2 stops16h 06m

Key West

Sun 3/1

2:25 pm-5:40 pm

1 stop27h 15m

$225

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Mon 2/16

8:28 pm-12:21 pm

1 stop15h 53m

Key West

Thu 2/19

11:01 am-9:59 pm

1 stop10h 58m

$228

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 2/26

6:35 pm-1:30 pm

1 stop18h 55m

Key West

Mon 3/2

1:06 pm-4:05 pm

2 stops26h 59m

$231

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 3/21

2:45 pm-9:06 am

1 stop18h 21m

Key West

Thu 3/26

10:33 pm-9:26 am

1 stop10h 53m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Key West

What is the cheapest month to book a flight from South Carolina to Key West?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Key West?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from South Carolina?

    For a flight from South Carolina to Key West, you will be flying into Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from South Carolina to Key West?

    For as low as $269, Breeze Airways can have you in Key West from South Carolina in 4h 12m. There are 714 mi between South Carolina and Key West. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Key West?

    When deciding which route to take from South Carolina to Key West consider Charlotte Douglas - Key West, Charleston - Key West or Greenville - Key West as they are the most popular.

  • Can I find deals for flights from South Carolina to Key West that include hotel bookings?

    Yes. In addition to deals on South Carolina to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Key West.

  • Can I find deals for business class flights from South Carolina to Key West?

    Yes. Cheapflights offers flight deals from South Carolina to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Key West?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Key West (average of $64). Flying from South Carolina to Key West in April is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Key West

Discover the top 3 airlines that operate flights from South Carolina to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$95Average$211FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$223Average$454FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$467FlexibilityNo cancel feeOn-time71%

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