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Key West

$92+ Cheap flights from South Carolina to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from South Carolina to Key West

Keep the following information in mind while searching for South Carolina to Key West flight deals. Data was last updated September 11, 2025.

Round-trip from

$206
(Expedia)

One-way from

$92
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$398
From South Carolina to Key West
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One-way flight from South Carolina to Key West
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Highest demand for flights based on searches. 15% potential increase in price ($82 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from South Carolina to Key West

Cheapest flights from South Carolina to Key West
Explore the most affordable flight options available from South Carolina to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/171:20 pmCLT - EYW
1 stop19h 42mMultiple Airlines
Wed 10/2210:02 amEYW - CLT
2 stops27h 38mMultiple Airlines
Deal found 9/9$206
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/271:20 pmCLT - EYW
1 stop21h 45mMultiple Airlines
Thu 10/308:33 pmEYW - CLT
1 stop15h 47mMultiple Airlines
Deal found 9/11$210
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:20 pmCLT - EYW
1 stop19h 42mMultiple Airlines
Mon 11/38:55 amEYW - CLT
1 stop22h 52mMultiple Airlines
Deal found 9/9$213
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/62:16 pmCLT - EYW
1 stop20h 03mMultiple Airlines
Sat 12/1310:47 amEYW - CLT
1 stop26h 34mMultiple Airlines
Deal found 9/9$215
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:55 pmCLT - EYW
1 stop13h 12mMultiple Airlines
Thu 9/258:55 amEYW - CLT
1 stop9h 26mMultiple Airlines
Deal found 9/9$220
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:05 pmCLT - EYW
1 stop12h 02mMultiple Airlines
Fri 10/319:57 amEYW - CLT
2 stops11h 02mMultiple Airlines
Deal found 9/8$221
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/510:06 pmCLT - EYW
1 stop10h 09mMultiple Airlines
Thu 10/94:54 pmEYW - CLT
1 stop16h 21mMultiple Airlines
Deal found 9/9$223
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/273:34 pmCLT - EYW
1 stop24h 26mMultiple Airlines
Fri 10/32:18 pmEYW - CLT
2 stops19h 04mMultiple Airlines
Deal found 9/11$227
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/101:20 pmCLT - EYW
1 stop19h 42mMultiple Airlines
Fri 10/249:45 pmEYW - CLT
2 stops23h 14mMultiple Airlines
Deal found 9/10$230
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/258:10 pmCHS - EYW
1 stop14h 09mMultiple Airlines
Fri 10/318:45 pmEYW - CHS
1 stop13h 22mMultiple Airlines
Deal found 9/10$238
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:33 amGSP - EYW
1 stop4h 40mAmerican Airlines
Sat 12/1311:35 amEYW - GSP
1 stop6h 18mAmerican Airlines
Deal found 9/11$249
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:09 pmMYR - EYW
1 stop5h 43mAmerican Airlines
Sat 12/1311:35 amEYW - MYR
2 stops7h 49mAmerican Airlines
Deal found 9/10$254

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

South Carolina

Fly to

Key West

Route

Depart

Return

Price

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sun 10/5

10:06 pm-8:15 am

1 stop10h 09m

Key West

Thu 10/9

10:59 am-8:59 pm

2 stops10h 00m

$244

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sat 12/6

11:33 am-4:13 pm

1 stop4h 40m

Key West

Sat 12/13

11:35 am-5:53 pm

1 stop6h 18m

$249

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sat 1/10

2:35 pm-6:35 pm

1 stop4h 00m

Key West

Sat 1/17

7:57 pm-12:15 am

1 stop4h 18m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

4:20 pm-11:54 pm

2 stops7h 34m

$254

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Thu 11/6

5:45 am-1:30 pm

1 stop7h 45m

Key West

Sun 11/9

2:25 pm-12:59 am

1 stop10h 34m

$265

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sun 11/23

2:16 pm-3:23 pm

1 stop25h 07m

Key West

Fri 12/12

3:54 pm-1:21 pm

1 stop21h 27m

$269

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sat 10/25

6:25 am-8:15 am

2 stops25h 50m

Key West

Fri 10/31

8:45 pm-10:07 am

1 stop13h 22m

$283

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 11/10

2:14 pm-11:05 am

1 stop20h 51m

Key West

Fri 11/14

8:55 am-7:35 pm

1 stop10h 40m

$288

SavannahKey West

SAV - EYW

SAVEYW

Savannah/Hilton Head

Fri 10/17

11:02 am-7:55 pm

1 stop8h 53m

Key West

Wed 10/22

10:47 am-10:17 pm

2 stops35h 30m

$291

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sat 11/1

4:14 pm-8:06 pm

1 stop3h 52m

Key West

Sat 11/8

6:17 pm-11:59 pm

1 stop5h 42m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Key West

What is the cheapest month to book a flight from South Carolina to Key West?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Key West (average of $328). Flying from South Carolina to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EYW?

Find hourly flight availability from South Carolina to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Key West as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from South Carolina?

    For a flight from South Carolina to Key West, you will be flying into Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from South Carolina to Key West?

    For as low as $297, American Airlines can have you in Key West from South Carolina in 3h 52m. There are 585 mi between South Carolina and Key West. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Key West one-way?

    $126 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Breeze Airways and Allegiant Air, with prices starting from $130 and $134, respectively.

  • What are the most popular routes from South Carolina to Key West?

    When deciding which route to take from South Carolina to Key West consider Charlotte Douglas - Key West, Charleston - Key West or Myrtle Beach Intl - Key West as they are the most popular.

  • Can I find deals for flights from South Carolina to Key West that include hotel bookings?

    Yes. In addition to deals on South Carolina to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Key West.

  • Can I find deals for business class flights from South Carolina to Key West?

    Yes. Cheapflights offers flight deals from South Carolina to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Key West?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Key West (average of $328). Flying from South Carolina to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from South Carolina to Key West

Discover the top 2 airlines that operate flights from South Carolina to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$462FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$493FlexibilityNo cancel feeOn-time71%

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