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$110+ Cheap flights from Knoxville to Key West (TYS - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Key West are usually found in June or March, booked 48 days in advance, depart on a Monday or Thursday and return on a Monday

Cheap flight deals from Knoxville to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$130
(Kiwi.com)

One-way from

$110
(Mytrip)

Popular in

September

Cheapest in

June

Average price

$354

Good round-trip deal

$140 or less
From Knoxville McGhee Tyson to Key West
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One-way flight from Knoxville McGhee Tyson to Key West
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Highest demand for flights based on searches. 3% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Knoxville McGhee Tyson to Key West.
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Find flight deals from Knoxville to Key West

Cheapest flights from Knoxville to Key West
Explore the most affordable flight options available from Knoxville to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Booking.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:44 pmTYS - EYW
Nonstop2h 11mAllegiant Air
Mon 11/33:05 pmEYW - TYS
Nonstop2h 15mAllegiant Air
Deal found 7/27$114
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/213:48 pmTYS - EYW
1 stop4h 18mDelta
Wed 10/296:17 pmEYW - TYS
1 stop4h 50mDelta
Deal found 7/28$249
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/218:15 amTYS - EYW
2 stops9h 01mAmerican Airlines
Wed 10/297:52 pmEYW - TYS
1 stop3h 43mAmerican Airlines
Deal found 7/27$254
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:44 pmTYS - EYW
Nonstop2h 11mMultiple Airlines
Mon 11/38:47 amEYW - TYS
2 stops25h 46mMultiple Airlines
Deal found 7/27$289

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Knoxville to Key West that are best for you.

Fly from

Knoxville

Fly to

Key West

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/24

6:44 pm-8:55 pm

Nonstop2h 11m

Key West

Mon 10/27

2:57 pm-5:12 pm

Nonstop2h 15m

$130

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Tue 10/21

3:48 pm-8:06 pm

1 stop4h 18m

Key West

Wed 10/29

6:17 pm-11:07 pm

1 stop4h 50m

$249

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Tue 10/21

8:15 am-5:16 pm

2 stops9h 01m

Key West

Wed 10/29

7:52 pm-11:35 pm

1 stop3h 43m

$254

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 8/11

6:00 am-1:07 pm

1 stop7h 07m

Key West

Fri 8/15

5:31 pm-10:23 pm

1 stop4h 52m

$294

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/3

9:54 pm-9:02 am

1 stop11h 08m

$110

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 8/16

10:54 am-9:22 am

2 stops22h 28m

$247

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/3

11:18 am-5:46 pm

1 stop6h 28m

$287

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 10/3

4:40 pm-2:29 pm

3 stops21h 49m

$1,793

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Knoxville to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Key West

How far ahead should I book a flight from Knoxville to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Key West. Price data was last updated on July 25, 2025.

To ensure you get the cheapest price possible for a flight from Knoxville to Key West, you should look to book at least 48 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to Key West?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Key West (average of $328). Flying from Knoxville to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EYW?

Find hourly flight availability from Knoxville to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Key West in the morning. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated July 29, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Key West have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,979 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Key West round-trip?

    According to our current data, Allegiant Air ($130), Delta ($249), and American Airlines ($254) offers the cheapest pricing from Knoxville to Key West. Allegiant Air is currently priced 66% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Knoxville to Key West one-way?

    $110 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $287 and $1,793, respectively.

  • What are the cheapest flights from Knoxville to Key West?

    Looking for the cheapest flight from Knoxville to Key West? While on average our users pay $140, our data indicates the cheapest price to be $100. The most popular route (Knoxville McGhee Tyson - Key West), is priced around $114.

  • Can I find deals for flights from Knoxville to Key West that include hotel bookings?

    Yes. In addition to deals on Knoxville to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Key West.

  • Can I find deals for business class flights from Knoxville to Key West?

    Yes. Cheapflights offers flight deals from Knoxville to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Key West?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Key West (average of $328). Flying from Knoxville to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Key West

Discover the top 3 airlines that operate flights from Knoxville to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$150FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$253Average$439FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$453FlexibilityNo cancel feeOn-timeN/A

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