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Key Largo

$118+ Cheap flights from Des Moines (DSM) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Key Largo are usually found in June or September, booked 40 days in advance, depart on a Monday or Thursday and return on a Wednesday

Cheap flight deals from Des Moines to Key Largo

Keep the following information in mind while searching for Des Moines to Key Largo flight deals. Data was last updated June 12, 2025.

Round-trip from

$192
(Southwest)

One-way from

$143
(FlightHub)

Popular in

March

Cheapest in

June

Average price

$306
From Des Moines to Key Largo
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One-way flight from Des Moines to Key Largo
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Highest demand for flights based on searches. 9% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Key Largo

Cheapest flights from Des Moines to Key Largo
Explore the most affordable flight options available from Des Moines to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/75:25 amDSM - MIA
1 stop6h 45mSouthwest
Tue 7/86:50 amMIA - DSM
1 stop7h 10mSouthwest
Deal found 6/10$192
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/206:30 amDSM - MIA
1 stop27h 19mMultiple Airlines
Thu 7/2411:10 amMIA - DSM
1 stop12h 28mMultiple Airlines
Deal found 6/10$201
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:40 pmDSM - MIA
1 stop5h 07mDelta
Tue 7/156:55 amMIA - DSM
1 stop7h 44mDelta
Deal found 6/10$217
This FlightHub deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/283:23 pmDSM - MIA
1 stop14h 07mFrontier
Mon 9/86:00 amMIA - DSM
1 stop14h 56mFrontier
Deal found 6/12$275
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/88:00 amDSM - MIA
2 stops10h 39mUnited Airlines
Tue 7/154:16 pmMIA - DSM
1 stop7h 44mUnited Airlines
Deal found 6/12$301
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:54 amDSM - MIA
Nonstop3h 26mAmerican Airlines
Sat 11/89:00 pmMIA - DSM
Nonstop3h 45mAmerican Airlines
Deal found 6/12$320

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Key Largo that are best for you.

Fly from

Des Moines

Fly to

Key Largo

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 7/7

5:25 am-1:10 pm

1 stop6h 45m

Miami

Tue 7/8

6:50 am-1:00 pm

1 stop7h 10m

$192

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 7/20

6:30 am-10:49 am

1 stop27h 19m

Miami

Thu 7/24

11:10 am-10:38 pm

1 stop12h 28m

$201

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 7/8

6:40 pm-12:47 am

1 stop5h 07m

Miami

Tue 7/15

6:55 am-1:39 pm

1 stop7h 44m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 8/28

3:23 pm-6:30 am

1 stop14h 07m

Miami

Mon 9/8

6:00 am-7:56 pm

1 stop14h 56m

$275

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 7/8

8:00 am-7:39 pm

2 stops10h 39m

Miami

Tue 7/15

4:16 pm-11:00 pm

1 stop7h 44m

$301

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 11/2

5:54 am-10:20 am

Nonstop3h 26m

Miami

Sat 11/8

9:00 pm-11:45 pm

Nonstop3h 45m

$320

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 10/22

8:15 am-3:11 pm

1 stop5h 56m

$118

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 8/28

3:23 pm-6:30 am

1 stop14h 07m

$143

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 9/15

8:25 am-6:14 pm

2 stops32h 49m

$152

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Best time to book a flight from Des Moines to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key Largo

How far ahead should I book a flight from Des Moines to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key Largo. Price data was last updated on June 9, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Key Largo, you should look to book at least 40 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $228). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KE9?

Find hourly flight availability from Des Moines to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Des Moines to Key Largo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Des Moines to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Des Moines to Key Largo flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Key Largo by month

Plan your trip to Key Largo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key Largo ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Key Largo when rainfall is around 1.6 in.

Temperature in Key Largo by month

Plan your trip to Key Largo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key Largo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated June 12, 2025.
Read through reviews of airlines operating flights from Des Moines to Key Largo, such as Southwest, Delta and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,950 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Frontier
5.9
Fair
3,295 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Overall

8.0

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Key Largo. 5 airlines have flights from Des Moines to Key Largo on a regular basis. Booking flights from Des Moines to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • What are the most reliable airlines from Des Moines to Key Largo?

    Consider American Airlines (50%), Qatar Airways (50%) or Envoy Air (50%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Key Largo.

  • What are the cheapest flights from Des Moines to Key Largo?

    The cheapest flight price from Des Moines to Key Largo is $272. On average you can expect to pay $574. The most popular route, (Des Moines - Miami), can usually be booked for $192.

  • Can I find deals for flights from Des Moines to Key Largo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key Largo.

  • Can I find deals for business class flights from Des Moines to Key Largo?

    Yes. Cheapflights offers flight deals from Des Moines to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $228). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 5 airlines flying from Des Moines to Key Largo

Discover the top 5 airlines that operate flights from Des Moines to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$209FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$418FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$221Average$474FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$268Average$438FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$305Average$467FlexibilityNo cancel feeOn-time63%

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