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Key Largo

$96+ Cheap flights from Des Moines (DSM) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Key Largo are usually found in September or August, booked 14 days in advance, depart on a Monday or Tuesday and return on a Wednesday

Cheap flight deals from Des Moines to Key Largo

Keep the following information in mind while searching for Des Moines to Key Largo flight deals. Data was last updated May 1, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$208
(Frontier)

One-way from

$96
(Mytrip)

Popular in

March

Cheapest in

September

Average price

$412
Provider with most accurate pricing for Des Moines-Miami flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Miami flights.
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From Des Moines to Key Largo
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One-way flight from Des Moines to Key Largo
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Highest demand for flights based on searches. 4% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Des Moines to Key Largo

Cheapest flights from Des Moines to Key Largo
Explore the most affordable flight options available from Des Moines to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:20 pmDSM - MIA
1 stop9h 02mFrontier
Wed 5/216:00 amMIA - DSM
1 stop13h 30mFrontier
Deal found 4/30$208
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/276:47 pmDSM - MIA
1 stop5h 10mDelta
Wed 7/25:50 pmMIA - DSM
1 stop6h 13mDelta
Deal found 4/30$217
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/46:25 amDSM - MIA
1 stop7h 49mUnited Airlines
Sat 6/76:30 amMIA - DSM
1 stop8h 45mUnited Airlines
Deal found 4/30$257
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/410:31 amDSM - MIA
2 stops32h 27mMultiple Airlines
Sat 6/78:52 pmMIA - DSM
1 stop15h 57mMultiple Airlines
Deal found 4/30$272
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/41:12 pmDSM - MIA
1 stop8h 34mAmerican Airlines
Sat 6/77:41 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 4/30$300
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:25 amDSM - MIA
1 stop4h 40mSouthwest
Tue 10/77:55 amMIA - DSM
2 stops14h 00mSouthwest
Deal found 4/30$311

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Des Moines to Key Largo that are best for you.

Fly from

Des Moines

Fly to

Key Largo

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/16

7:20 pm-5:22 am

1 stop9h 02m

Miami

Wed 5/21

6:00 am-6:30 pm

1 stop13h 30m

$208

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 6/27

6:47 pm-12:57 am

1 stop5h 10m

Miami

Wed 7/2

5:50 pm-11:03 pm

1 stop6h 13m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 6/4

6:25 am-3:14 pm

1 stop7h 49m

Miami

Sat 6/7

6:30 am-2:15 pm

1 stop8h 45m

$257

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 6/4

10:31 am-7:58 pm

2 stops32h 27m

Miami

Sat 6/7

8:52 pm-11:49 am

1 stop15h 57m

$272

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 6/4

1:12 pm-10:46 pm

1 stop8h 34m

Miami

Sat 6/7

7:41 pm-10:20 pm

Nonstop3h 39m

$300

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 9/30

8:25 am-2:05 pm

1 stop4h 40m

Miami

Tue 10/7

7:55 am-8:55 pm

2 stops14h 00m

$311

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 6/14

1:15 pm-11:37 am

1 stop21h 22m

$96

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/30

1:07 pm-10:55 pm

1 stop8h 48m

$109

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 8/2

6:45 am-11:09 am

Nonstop3h 24m

$139

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 5/20

5:45 am-3:54 pm

2 stops9h 09m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 12 results
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Best time to book a flight from Des Moines to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key Largo

How far ahead should I book a flight from Des Moines to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key Largo. Price data was last updated on April 25, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Key Largo, you should look to book at least 14 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $228). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KE9?

Find hourly flight availability from Des Moines to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Des Moines to Key Largo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Des Moines to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Des Moines to Key Largo flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Key Largo by month

Plan your trip to Key Largo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key Largo ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Key Largo when rainfall is around 1.6 in.

Temperature in Key Largo by month

Plan your trip to Key Largo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key Largo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated May 1, 2025.
Read through reviews of airlines operating flights from Des Moines to Key Largo, such as Southwest, Delta and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Frontier
6.0
Okay
3,287 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Entertainment

7.6

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Key Largo. 6 airlines have flights from Des Moines to Key Largo on a regular basis. Booking flights from Des Moines to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • What are the cheapest airlines to fly from Des Moines to Key Largo one-way?

    One-way options have recently been found by users for as low as $109 on Delta. Other airlines that offer cheap prices include American Airlines from $139 and United Airlines from $159 one-way.

  • What are the most reliable airlines from Des Moines to Key Largo?

    Consider American Airlines (44%), Qatar Airways (44%) or Envoy Air (44%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Key Largo.

  • What are the cheapest flights from Des Moines to Key Largo?

    The cheapest flight price from Des Moines to Key Largo is $225. On average you can expect to pay $401. The most popular route, (Des Moines - Miami), can usually be booked for $217.

  • Can I find deals for flights from Des Moines to Key Largo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key Largo.

  • Can I find deals for business class flights from Des Moines to Key Largo?

    Yes. Cheapflights offers flight deals from Des Moines to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $228). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 6 airlines flying from Des Moines to Key Largo

Discover the top 6 airlines that operate flights from Des Moines to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$70Average$223FlexibilityNo cancel feeOn-time88%
FrontierCheapest$216Average$271FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$221Average$470FlexibilityNo cancel feeOn-time69%
DeltaCheapest$221Average$415FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$267Average$437FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$305Average$470FlexibilityNo cancel feeOn-time63%

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