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Key Largo

$90+ Cheap flights from Des Moines (DSM) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Key Largo are usually found in June or August, booked 39 days in advance, depart on a Thursday or Tuesday and return on a Wednesday

Cheap flight deals from Des Moines to Key Largo

Keep the following information in mind while searching for Des Moines to Key Largo flight deals. Data was last updated September 15, 2025.

Round-trip from

$179
(Southwest)

One-way from

$90
(Southwest)

Popular in

March

Cheapest in

June

Average price

$410
From Des Moines to Key Largo
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One-way flight from Des Moines to Key Largo
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Highest demand for flights based on searches. 9% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Key Largo

Cheapest flights from Des Moines to Key Largo
Explore the most affordable flight options available from Des Moines to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:50 pmDSM - MIA
1 stop4h 45mSouthwest
Wed 10/291:55 pmMIA - DSM
2 stops8h 55mSouthwest
Deal found 9/14$184
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/135:35 amDSM - MIA
1 stop9h 40mSouthwest
Thu 10/167:20 amMIA - DSM
2 stops17h 10mSouthwest
Deal found 9/14$211
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/212:25 pmDSM - MIA
1 stop9h 19mFrontier
Sun 9/286:00 amMIA - DSM
1 stop8h 40mFrontier
Deal found 9/14$215
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2211:06 amDSM - MIA
1 stop5h 47mDelta
Tue 10/286:15 pmMIA - DSM
1 stop5h 15mDelta
Deal found 9/13$217
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:47 pmDSM - MIA
1 stop13h 58mMultiple Airlines
Fri 10/176:00 amMIA - DSM
1 stop12h 14mMultiple Airlines
Deal found 9/14$222
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:25 pmDSM - MIA
1 stop9h 19mFrontier
Sun 10/56:00 amMIA - DSM
1 stop8h 40mFrontier
Deal found 9/14$228
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:08 pmDSM - MIA
1 stop5h 48mAmerican Airlines
Tue 12/98:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 9/14$230
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/287:06 amDSM - MIA
1 stop8h 17mAmerican Airlines
Tue 11/48:50 pmMIA - DSM
Nonstop3h 43mAmerican Airlines
Deal found 9/13$231
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:32 pmDSM - MIA
1 stop14h 47mMultiple Airlines
Mon 11/36:00 amMIA - DSM
1 stop7h 53mMultiple Airlines
Deal found 9/12$233
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:30 amDSM - MIA
2 stops16h 04mMultiple Airlines
Thu 11/1311:28 amMIA - DSM
1 stop9h 45mMultiple Airlines
Deal found 9/13$240
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/192:25 pmDSM - MIA
1 stop9h 19mFrontier
Sun 9/286:00 amMIA - DSM
1 stop8h 40mFrontier
Deal found 9/13$242
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:50 pmDSM - MIA
1 stop4h 45mSouthwest
Thu 11/65:25 pmMIA - DSM
2 stops7h 10mSouthwest
Deal found 9/13$245

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Des Moines to Key Largo that are best for you.

Fly from

Des Moines

Fly to

Key Largo

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 10/25

3:50 pm-9:35 pm

1 stop4h 45m

Miami

Wed 10/29

1:55 pm-9:50 pm

2 stops8h 55m

$184

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 10/22

11:06 am-5:53 pm

1 stop5h 47m

Miami

Tue 10/28

6:15 pm-10:30 pm

1 stop5h 15m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 11/6

7:30 am-12:34 am

2 stops16h 04m

Miami

Thu 11/13

11:28 am-8:13 pm

1 stop9h 45m

$240

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 11/13

2:32 pm-6:19 am

1 stop14h 47m

Miami

Sat 11/15

11:28 am-1:47 pm

2 stops27h 19m

$256

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 9/27

10:55 am-5:30 pm

1 stop5h 35m

Miami

Sat 10/4

6:00 am-10:40 am

1 stop5h 40m

$290

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 10/17

6:39 pm-12:29 am

1 stop4h 50m

Miami

Mon 10/27

6:00 am-10:05 am

1 stop5h 05m

$301

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 12/7

11:01 am-6:07 pm

1 stop6h 06m

Miami

Thu 12/18

6:00 am-10:43 am

1 stop5h 43m

$320

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 10/11

3:50 pm-9:35 pm

1 stop4h 45m

Miami

Tue 10/14

11:45 am-9:50 pm

2 stops11h 05m

$331

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 11/8

1:35 pm-9:59 pm

1 stop7h 24m

Miami

Sat 11/15

6:05 am-2:19 pm

2 stops9h 14m

$342

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 9/23

8:25 am-2:05 pm

1 stop4h 40m

Miami

Wed 9/24

2:50 pm-10:20 pm

1 stop8h 30m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 22 results
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Best time to book a flight from Des Moines to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key Largo

How far ahead should I book a flight from Des Moines to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key Largo. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Key Largo, you should look to book at least 39 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $232). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KE9?

Find hourly flight availability from Des Moines to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Des Moines to Key Largo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Des Moines to Key Largo, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,245 reviews
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,956 reviews
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,931 reviews
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
699 reviews
Southwest
8.0
Very good
4,245 reviews

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Key Largo. 5 airlines have flights from Des Moines to Key Largo on a regular basis. Booking flights from Des Moines to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Des Moines to Key Largo?

    For as low as $184, Southwest can have you in Key Largo from Des Moines in 4h 45m. The distance between Des Moines and Key Largo is about 1328 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Des Moines to Key Largo?

    Consider Qatar Airways (68%), American Airlines (67%) or Republic Airways (67%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Key Largo.

  • What are the cheapest flights from Des Moines to Key Largo?

    The cheapest flight price from Des Moines to Key Largo is $320. On average you can expect to pay $594. The most popular route, (Des Moines - Miami), can usually be booked for $179.

  • Can I find deals for flights from Des Moines to Key Largo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key Largo.

  • Can I find deals for business class flights from Des Moines to Key Largo?

    Yes. Cheapflights offers flight deals from Des Moines to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $232). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Des Moines to Key Largo

Discover the top 5 airlines that operate flights from Des Moines to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$177FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$214Average$482FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$404FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$244Average$459FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$268Average$466FlexibilityNo cancel feeOn-time71%

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