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Key Largo

$85+ Cheap flights from Des Moines (DSM) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
nov. 29 — déc. 61
sam. 11/29
sam. 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Key Largo are usually found in June or August, booked 39 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Find flight deals from Des Moines to Key Largo

Cheapest flights from Des Moines to Key Largo
Explore the most affordable flight options available from Des Moines to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octobre 30, 2025.

This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/26:15 amDSM - MIA
1 stop5h 10mSouthwest
jeu. 12/41:45 pmMIA - DSM
1 stop7h 10mSouthwest
Deal found 10/29$179
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/96:00 amDSM - MIA
Nonstop3h 28mAmerican Airlines
mar. 12/168:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 10/28$199
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/172:32 pmDSM - MIA
2 stops21h 56mMultiple Airlines
jeu. 11/2012:41 pmMIA - DSM
1 stop25h 14mMultiple Airlines
Deal found 10/27$205
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 12/612:31 pmDSM - MIA
1 stop8h 19mDelta
sam. 12/137:00 amMIA - DSM
1 stop8h 12mDelta
Deal found 10/28$217
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/108:40 amDSM - MIA
1 stop26h 27mMultiple Airlines
jeu. 11/137:30 amMIA - DSM
1 stop16h 33mMultiple Airlines
Deal found 10/28$225
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 12/42:08 pmDSM - MIA
1 stop7h 25mAmerican Airlines
mar. 12/98:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 10/28$230

Cheap flight deals from Des Moines to Key Largo

Keep the following information in mind while searching for Des Moines to Key Largo flight deals. Data was last updated octobre 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$179
(Southwest)

One-way from

$85
(Priceline)

Popular in

March

Cheapest in

June

Average price

$413
Provider with most accurate pricing for Des Moines-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Miami flights.
Search Deals
From Des Moines to Key Largo
Search Deals
One-way flight from Des Moines to Key Largo
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($51 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 30, 2025.
Use the filters below to find and compare flights from Des Moines to Key Largo that are best for you.

Fly from

Des Moines

Fly to

Key Largo

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

sam. 12/6

12:31 pm-9:50 pm

1 stop8h 19m

Miami

sam. 12/13

6:00 am-10:38 am

1 stop5h 38m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

dim. 12/14

11:01 am-5:34 pm

1 stop5h 33m

Miami

dim. 12/21

6:00 am-10:38 am

1 stop5h 38m

$252

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

mer. 1/14

5:16 pm-12:51 am

1 stop6h 35m

Miami

mer. 1/21

11:33 am-7:34 pm

1 stop9h 01m

$257

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

ven. 12/5

6:33 pm-12:46 am

1 stop5h 13m

Miami

sam. 12/13

6:00 am-10:38 am

1 stop5h 38m

$259

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

sam. 12/13

3:00 pm-9:10 pm

1 stop5h 10m

Miami

sam. 12/20

6:25 am-11:28 am

1 stop6h 03m

$298

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

mer. 12/3

2:16 pm-8:51 pm

1 stop5h 35m

Miami

dim. 12/7

6:00 am-10:38 am

1 stop5h 38m

$320

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

mar. 12/9

6:50 am-1:32 pm

1 stop5h 42m

Miami

dim. 12/14

6:00 am-10:38 am

1 stop5h 38m

$320

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

lun. 1/26

11:09 am-5:26 pm

1 stop5h 17m

$98

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

lun. 12/15

7:58 pm-12:42 pm

2 stops15h 44m

$122

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

mar. 1/27

8:35 am-4:30 pm

1 stop6h 55m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 15 results
1
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Best time to book a flight from Des Moines to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key Largo

How far ahead should I book a flight from Des Moines to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key Largo. Price data was last updated on October 24, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Key Largo, you should look to book at least 39 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Key Largo?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $82). Flying from Des Moines to Key Largo in September is currently the most expensive (average of $204). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KE9?

Find hourly flight availability from Des Moines to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octobre 30, 2025.

When flying from Des Moines to Key Largo, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 14% versus a flight in the morning.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated octobre 30, 2025.
Read through reviews of airlines operating flights from Des Moines to Key Largo, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,998 reviews
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,998 reviews
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,035 reviews
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
694 reviews
Southwest
8.0
Very good
4,243 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Key Largo. 5 airlines have flights from Des Moines to Key Largo on a regular basis. Booking flights from Des Moines to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Des Moines to Key Largo?

    For as low as $217, Delta can have you in Key Largo from Des Moines in 8h 19m. The distance between Des Moines and Key Largo is about 1328 mi.

  • What are the cheapest airlines to fly from Des Moines to Key Largo one-way?

    One-way options have recently been found by users for as low as $122 on Frontier. Other airlines that offer cheap prices include Southwest from $129 and Delta from $144 one-way.

  • What are the most reliable airlines from Des Moines to Key Largo?

    Consider American Airlines (100%), Qatar Airways (100%) or Republic Airways (100%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Key Largo.

  • What are the cheapest flights from Des Moines to Key Largo?

    The cheapest flight price from Des Moines to Key Largo is $146. On average you can expect to pay $464. The most popular route, (Des Moines - Miami), can usually be booked for $179.

  • Can I find deals for flights from Des Moines to Key Largo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key Largo.

  • Can I find deals for business class flights from Des Moines to Key Largo?

    Yes. Cheapflights offers flight deals from Des Moines to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key Largo?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $82). Flying from Des Moines to Key Largo in September is currently the most expensive (average of $204). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Des Moines to Key Largo

Discover the top 5 airlines that operate flights from Des Moines to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$178FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$407FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$226Average$473FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$228Average$455FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$268Average$468FlexibilityNo cancel feeOn-time71%

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