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Key Largo

$89+ Cheap flights from Des Moines (DSM) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Key Largo are usually found in June or September, booked 39 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Des Moines to Key Largo

Keep the following information in mind while searching for Des Moines to Key Largo flight deals. Data was last updated July 29, 2025.

Round-trip from

$178
(Southwest)

One-way from

$89
(Southwest)

Popular in

March

Cheapest in

June

Average price

$462
From Des Moines to Key Largo
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One-way flight from Des Moines to Key Largo
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Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Key Largo

Cheapest flights from Des Moines to Key Largo
Explore the most affordable flight options available from Des Moines to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/215:25 pmDSM - MIA
1 stop5h 40mSouthwest
Fri 9/266:55 pmMIA - DSM
1 stop4h 55mSouthwest
Deal found 7/27$178
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:30 pmDSM - MIA
1 stop4h 54mDelta
Wed 9/177:30 amMIA - DSM
1 stop6h 50mDelta
Deal found 7/27$217
This Trip.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/122:25 pmDSM - MIA
1 stop9h 19mFrontier
Mon 9/156:00 amMIA - DSM
1 stop8h 40mFrontier
Deal found 7/28$253
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/267:59 amDSM - MIA
1 stop7h 34mAmerican Airlines
Sat 8/307:51 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 7/27$261
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/106:30 amDSM - MIA
1 stop12h 34mMultiple Airlines
Fri 8/2210:23 amMIA - DSM
2 stops11h 18mMultiple Airlines
Deal found 7/29$274
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/161:20 pmDSM - MIA
1 stop7h 35mUnited Airlines
Fri 9/194:53 pmMIA - DSM
1 stop6h 35mUnited Airlines
Deal found 7/28$277

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Des Moines to Key Largo that are best for you.

Fly from

Des Moines

Fly to

Key Largo

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 9/21

5:25 pm-12:05 am

1 stop5h 40m

Miami

Fri 9/26

6:55 pm-10:50 pm

1 stop4h 55m

$178

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 9/10

6:30 pm-12:24 am

1 stop4h 54m

Miami

Wed 9/17

7:30 am-1:20 pm

1 stop6h 50m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 9/12

2:25 pm-12:44 am

1 stop9h 19m

Miami

Mon 9/15

6:00 am-1:40 pm

1 stop8h 40m

$253

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 8/26

7:59 am-4:33 pm

1 stop7h 34m

Miami

Sat 8/30

7:51 pm-10:30 pm

Nonstop3h 39m

$261

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 9/16

1:20 pm-9:55 pm

1 stop7h 35m

Miami

Fri 9/19

4:53 pm-10:28 pm

1 stop6h 35m

$277

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 9/7

3:42 pm-6:04 pm

2 stops25h 22m

Miami

Thu 9/25

6:00 am-4:59 pm

2 stops11h 59m

$279

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 8/26

8:25 am-2:05 pm

1 stop4h 40m

$89

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 12/12

8:15 pm-5:08 am

1 stop7h 53m

$123

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 11/1

1:05 pm-11:59 pm

2 stops9h 54m

$134

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 9/7

3:42 pm-6:04 pm

2 stops25h 22m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 12 results
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Best time to book a flight from Des Moines to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key Largo

How far ahead should I book a flight from Des Moines to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key Largo. Price data was last updated on July 25, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Key Largo, you should look to book at least 39 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $232). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to KE9?

Find hourly flight availability from Des Moines to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from Des Moines to Key Largo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Des Moines to Key Largo?

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Des Moines to Key Largo, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,899 reviews
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,238 reviews
Southwest
8.0
Very good
4,238 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Key Largo. 5 airlines have flights from Des Moines to Key Largo on a regular basis. Booking flights from Des Moines to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • What are the cheapest airlines to fly from Des Moines to Key Largo one-way?

    One-way options have recently been found by users for as low as $89 on Southwest. Other airlines that offer cheap prices include Frontier from $123 and United Airlines from $134 one-way.

  • What are the most reliable airlines from Des Moines to Key Largo?

    Consider American Airlines (67%), Republic Airways (67%) or Qatar Airways (67%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Key Largo.

  • What are the cheapest flights from Des Moines to Key Largo?

    The cheapest flight price from Des Moines to Key Largo is $330. On average you can expect to pay $589. The most popular route, (Des Moines - Miami), can usually be booked for $178.

  • Can I find deals for flights from Des Moines to Key Largo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key Largo.

  • Can I find deals for business class flights from Des Moines to Key Largo?

    Yes. Cheapflights offers flight deals from Des Moines to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Key Largo (average of $232). Flying from Des Moines to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 5 airlines flying from Des Moines to Key Largo

Discover the top 5 airlines that operate flights from Des Moines to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$178FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$403FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$221Average$484FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$268Average$440FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$268Average$461FlexibilityNo cancel feeOn-time63%

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