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$79+ Cheap flights from Mississippi to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Mississippi to Iowa

Cheapest flights from Mississippi to Iowa
Explore the most affordable flight options available from Mississippi to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:12 amMEM - MLI
1 stop5h 27mAmerican Airlines
Sun 1/47:47 pmMLI - MEM
1 stop5h 57mAmerican Airlines
Deal found 12/16$244
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:12 amMEM - MLI
1 stop5h 27mAmerican Airlines
Mon 12/227:47 pmMLI - MEM
1 stop4h 10mAmerican Airlines
Deal found 12/16$309
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amMEM - DSM
1 stop8h 21mAmerican Airlines
Sun 12/286:52 pmDSM - MEM
1 stop5h 07mAmerican Airlines
Deal found 12/14$318
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:34 pmBTR - DSM
1 stop8h 03mAmerican Airlines
Tue 1/64:00 pmDSM - BTR
1 stop6h 56mAmerican Airlines
Deal found 12/16$319
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:00 amMEM - DSM
2 stops7h 54mAmerican Airlines
Sun 1/46:52 pmDSM - MEM
1 stop6h 52mAmerican Airlines
Deal found 12/16$378
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:32 amBTR - DSM
1 stop5h 17mAmerican Airlines
Thu 1/12:07 pmDSM - BTR
1 stop5h 50mAmerican Airlines
Deal found 12/16$394
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:55 amMEM - DSM
1 stop5h 33mDelta
Fri 1/26:30 pmDSM - MEM
1 stop4h 41mDelta
Deal found 12/14$407
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:00 amMEM - DSM
2 stops7h 54mAmerican Airlines
Fri 1/26:40 amDSM - MEM
1 stop4h 40mAmerican Airlines
Deal found 12/14$412
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:49 pmMEM - CID
1 stop6h 41mAmerican Airlines
Sun 1/46:00 amCID - MEM
1 stop5h 22mAmerican Airlines
Deal found 12/16$432
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:09 amBTR - DSM
1 stop6h 52mAmerican Airlines
Sun 1/45:07 amDSM - BTR
1 stop4h 32mAmerican Airlines
Deal found 12/16$439
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amMEM - OMA
1 stop4h 54mDelta
Fri 1/26:42 amOMA - MEM
1 stop4h 51mDelta
Deal found 12/16$447
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:00 amMEM - OMA
2 stops8h 38mAmerican Airlines
Fri 1/25:38 pmOMA - MEM
1 stop6h 18mAmerican Airlines
Deal found 12/16$452

Find flight deals from Mississippi to Iowa

Keep the following information in mind while searching for Mississippi to Iowa flight deals. Data was last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(Delta)

One-way from

$79
(Trip.com)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
Search Deals
From Mississippi to Iowa
Search Deals
One-way flight from Mississippi to Iowa
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Mississippi to Iowa that are best for you.

Fly from

Mississippi

Fly to

Iowa

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/7

5:50 am-10:19 am

1 stop4h 29m

Des Moines

Sat 2/14

5:24 am-11:01 am

1 stop5h 37m

$240

MemphisMoline

MEM - MLI

MEMMLI

Memphis

Wed 12/31

5:12 am-10:39 am

1 stop5h 27m

Moline Quad-City

Sun 1/4

7:47 pm-1:44 am

1 stop5h 57m

$244

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/7

8:37 am-4:24 pm

2 stops7h 47m

Des Moines

Sat 2/14

5:56 pm-11:09 pm

1 stop5h 13m

$245

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Fri 1/16

5:13 pm-10:30 pm

1 stop5h 17m

Des Moines

Mon 1/19

8:10 am-3:58 pm

1 stop7h 48m

$269

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Fri 1/16

5:31 am-10:50 am

1 stop5h 19m

Des Moines

Mon 1/19

1:16 pm-10:41 pm

2 stops9h 25m

$274

JacksonOmaha

JAN - OMA

JANOMA

Jackson-Evers Intl

Wed 1/28

5:14 pm-11:33 pm

1 stop6h 19m

Omaha Eppley Airfield

Sat 1/31

3:26 pm-11:50 pm

1 stop8h 24m

$294

MemphisMoline

MEM - MLI

MEMMLI

Memphis

Sat 1/17

7:00 am-10:58 am

1 stop3h 58m

Moline Quad-City

Mon 1/19

3:58 pm-10:51 pm

1 stop6h 53m

$296

JacksonOmaha

JAN - OMA

JANOMA

Jackson-Evers Intl

Wed 1/28

5:15 pm-10:21 pm

1 stop5h 06m

Omaha Eppley Airfield

Sat 1/31

5:52 am-4:02 pm

2 stops10h 10m

$299

MemphisMoline

MEM - MLI

MEMMLI

Memphis

Sat 2/21

9:55 am-4:47 pm

1 stop6h 52m

Moline Quad-City

Wed 2/25

6:30 am-10:57 am

1 stop4h 27m

$309

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 1/15

5:13 pm-10:30 pm

1 stop5h 17m

Des Moines

Sun 1/18

8:00 am-7:48 pm

2 stops11h 48m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 53 results
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Best time to book a flight from Mississippi to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Iowa

What is the cheapest time of day to fly from MS to IA?

Find hourly flight availability from Mississippi to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

When flying from Mississippi to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 38% versus a flight at noon.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 16, 2025.
Read through reviews of airlines operating flights from Mississippi to Iowa, such as Delta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Entertainment

7.9

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to Iowa?

    For as low as $240, Delta can have you in Iowa from Mississippi in 4h 29m. Airlines will cover a distance of 491 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to Iowa that include hotel bookings?

    Yes. In addition to deals on Mississippi to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Iowa.

  • Can I find deals for business class flights from Mississippi to Iowa?

    Yes. Cheapflights offers flight deals from Mississippi to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Iowa

Discover the top airline that operate flights from Mississippi to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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