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$80+ Cheap flights from Mississippi to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Mar 27 — Apr 31
Fri 3/27
Fri 4/3
1 adult, Economy
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Cheap flight deals from Mississippi to Iowa

Cheapest flights from Mississippi to Iowa
Explore the most affordable flight options available from Mississippi to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 25, 2026.

This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:45 pm
MEM
-
DSM
1 stop6h 42m
United Airlines
Thu 4/91:32 pm
DSM
-
MEM
1 stop7h 17m
United Airlines
Deal found 2/23$257
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:33 pm
BTR
-
OMA
1 stop7h 42m
American Airlines
Sun 3/295:19 am
OMA
-
BTR
1 stop4h 35m
American Airlines
Deal found 2/23$269
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
MOB
-
DSM
1 stop5h 05m
Delta
Tue 5/55:45 am
DSM
-
MOB
1 stop6h 18m
Delta
Deal found 2/21$269
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:37 pm
MEM
-
DSM
1 stop4h 25m
United Airlines
Thu 4/96:20 am
DSM
-
MEM
1 stop4h 34m
United Airlines
Deal found 2/23$274
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:00 am
BTR
-
MLI
2 stops8h 54m
United Airlines
Tue 5/196:35 am
MLI
-
BTR
2 stops8h 56m
United Airlines
Deal found 2/23$279
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:36 pm
MEM
-
OMA
1 stop27h 28m
Multiple Airlines
Mon 4/278:58 pm
OMA
-
MEM
2 stops13h 09m
Multiple Airlines
Deal found 2/22$281
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:20 am
BTR
-
OMA
2 stops9h 06m
United Airlines
Sun 8/304:45 pm
OMA
-
BTR
1 stop6h 01m
United Airlines
Deal found 2/23$284
This Southwest deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:20 pm
MEM
-
DSM
2 stops8h 55m
Southwest
Thu 4/94:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Deal found 2/23$288
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:42 pm
JAN
-
OMA
1 stop5h 33m
American Airlines
Tue 4/74:19 pm
OMA
-
JAN
1 stop6h 51m
American Airlines
Deal found 2/24$296
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/59:50 am
MEM
-
DSM
1 stop4h 35m
United Airlines
Thu 4/96:20 am
DSM
-
MEM
1 stop4h 34m
United Airlines
Deal found 2/23$299
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:39 pm
JAN
-
OMA
1 stop5h 43m
American Airlines
Sat 4/115:07 pm
OMA
-
JAN
1 stop6h 52m
American Airlines
Deal found 2/23$303
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:57 pm
GPT
-
MLI
1 stop4h 33m
Delta
Tue 4/145:11 pm
MLI
-
GPT
1 stop5h 02m
Delta
Deal found 2/22$304

Find flight deals from Mississippi to Iowa

Keep the following information in mind while searching for Mississippi to Iowa flight deals. Data was last updated February 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$257
(United Airlines)

One-way from

$80
(Priceline)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
Search Deals
From Mississippi to Iowa
Search Deals
One-way flight from Mississippi to Iowa
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Mississippi to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 4/7

2:45 pm-9:27 pm

1 stop6h 42m

Des Moines

Thu 4/9

1:32 pm-8:49 pm

1 stop7h 17m

$257

Baton RougeMoline

BTR - MLI

BTRMLI

Baton Rouge Ryan

Wed 5/13

5:00 am-1:54 pm

2 stops8h 54m

Moline Quad-City

Tue 5/19

6:35 am-3:31 pm

2 stops8h 56m

$279

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 4/11

5:37 pm-10:38 pm

1 stop5h 01m

Des Moines

Fri 4/17

10:56 am-5:58 pm

1 stop7h 02m

$299

JacksonOmaha

JAN - OMA

JANOMA

Jackson-Evers Intl

Thu 4/9

6:39 pm-12:22 am

1 stop5h 43m

Omaha Eppley Airfield

Sat 4/11

5:07 pm-11:59 pm

1 stop6h 52m

$303

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 4/11

6:12 pm-11:59 pm

1 stop5h 47m

Des Moines

Fri 4/17

11:09 am-7:47 pm

2 stops8h 38m

$304

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 4/22

9:00 am-2:22 pm

1 stop5h 22m

Des Moines

Tue 5/5

8:00 am-6:05 pm

2 stops10h 05m

$309

MemphisOmaha

MEM - OMA

MEMOMA

Memphis

Thu 4/23

11:35 am-7:06 pm

1 stop7h 31m

Omaha Eppley Airfield

Mon 4/27

1:52 pm-8:49 pm

1 stop6h 57m

$321

GulfportMoline

GPT - MLI

GPTMLI

Gulfport Biloxi Regional

Tue 3/31

5:57 pm-10:30 pm

1 stop4h 33m

Moline Quad-City

Wed 4/15

5:11 pm-10:13 pm

1 stop5h 02m

$324

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 4/7

3:25 pm-10:10 pm

2 stops6h 45m

Des Moines

Thu 4/9

5:25 am-4:40 pm

2 stops11h 15m

$329

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 3/11

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Mon 5/11

11:55 am-6:24 pm

1 stop6h 29m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 60 resultsSorted by cheapest first
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2
3
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6

Best time to book a flight from Mississippi to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Iowa
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated February 25, 2026.
Read through reviews of airlines operating flights from Mississippi to Iowa, such as Delta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,237 reviews

Food

7.2

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,237 reviews
Delta
7.9
Good
8,237 reviews

Food

7.2

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to Iowa?

    For as low as $299, United Airlines can have you in Iowa from Mississippi in 5h 01m. Airlines will cover a distance of 491 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to Iowa that include hotel bookings?

    Yes. In addition to deals on Mississippi to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Iowa.

  • Can I find deals for business class flights from Mississippi to Iowa?

    Yes. Cheapflights offers flight deals from Mississippi to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Iowa

Discover the top airline that operate flights from Mississippi to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$258FlexibilityNo cancel feeOn-timeN/A

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