$140+ Cheap flights from Missouri to Greenville (GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GSP
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Greenville
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Cheapest flights from Missouri to GreenvilleExplore the most affordable flight options available from Missouri to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from Missouri to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:30 pm -
1 stop3h 20m
Mon 12/76:45 pm -
1 stop4h 15m
Deal found 10/22![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:30 pm -
1 stop5h 23m
Fri 11/205:40 am -
1 stop4h 20m
Deal found 10/26![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:54 pm -
1 stop5h 18m
Wed 11/117:00 am -
1 stop5h 05m
Deal found 10/21![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 am -
1 stop4h 27m
Fri 11/135:40 am -
1 stop4h 45m
Deal found 10/21![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:40 am -
1 stop4h 33m
Sun 12/65:40 am -
1 stop6h 25m
Deal found 10/22![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/31:45 pm -
1 stop5h 06m
Sun 12/68:31 pm -
1 stop4h 53m
Deal found 10/24![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:56 am -
1 stop4h 16m
Mon 11/306:27 pm -
1 stop6h 34m
Deal found 10/21![American Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 am -
1 stop6h 35m
Sun 11/155:40 am -
1 stop4h 47m
Deal found 10/21![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:35 am -
1 stop5h 31m
Sun 11/157:02 am -
1 stop4h 51m
Deal found 10/21![American Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:47 pm -
1 stop21h 30m
Tue 11/243:51 pm -
1 stop23h 34m
Deal found 10/23![Allegiant Air logo]()
$356
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:35 pm -
1 stop3h 52m
Wed 11/1810:52 am -
1 stop7h 12m
Deal found 10/21![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:10 am -
1 stop5h 05m
Fri 11/275:40 am -
1 stop6h 25m
Deal found 10/23![Delta logo]()
$366
Best flights from Missouri to GreenvilleDiscover carefully curated flight deals from Missouri to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from Missouri to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:54 pm -
1 stop5h 18m
Tue 11/1712:12 pm -
1 stop5h 14m
Deal found 10/21![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:56 am -
1 stop4h 16m
Mon 11/306:27 pm -
1 stop6h 34m
Deal found 10/21![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/63:19 pm -
1 stop4h 44m
Tue 2/95:29 pm -
1 stop5h 17m
Deal found 10/25![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:45 am -
2 stops8h 30m
Wed 11/117:05 am -
2 stops7h 40m
Deal found 10/23![Southwest logo]()
$400
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:10 am -
1 stop6h 35m
Thu 11/125:40 am -
1 stop4h 47m
Deal found 10/21![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:54 pm -
1 stop6h 04m
Sun 11/158:35 pm -
1 stop4h 23m
Deal found 10/22![American Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:39 am -
1 stop6h 27m
Sun 2/72:35 pm -
1 stop5h 34m
Deal found 10/24![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/161:08 pm -
2 stops9h 39m
Fri 11/206:20 am -
1 stop6h 50m
Deal found 10/26![United Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:35 pm -
2 stops7h 25m
Tue 11/106:45 pm -
1 stop4h 45m
Deal found 10/22![Southwest logo]()
$414
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/41:02 pm -
1 stop6h 22m
Tue 2/92:35 pm -
1 stop5h 34m
Deal found 10/23![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:32 pm -
1 stop4h 19m
Tue 11/178:11 am -
1 stop5h 04m
Deal found 10/21![Delta logo]()
$414
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/911:36 am -
2 stops10h 58m
Sat 1/166:30 am -
1 stop5h 16m
Deal found 10/23![United Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:35 pm -
1 stop3h 52m
Wed 11/1810:52 am -
1 stop7h 12m
Deal found 10/21![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:00 pm -
2 stops8h 00m
Mon 11/98:50 pm -
1 stop4h 05m
Deal found 10/23![Southwest logo]()
$490
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/93:12 pm -
1 stop4h 51m
Wed 1/136:30 am -
1 stop5h 17m
Deal found 10/25![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:00 am -
1 stop4h 30m
Tue 11/1711:58 am -
2 stops12h 00m
Deal found 10/23![United Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:08 pm -
2 stops9h 39m
Sun 11/156:20 am -
1 stop5h 12m
Deal found 10/23![United Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/87:12 am -
1 stop5h 59m
Mon 4/124:28 pm -
1 stop7h 14m
Deal found 10/21![American Airlines logo]()
$548
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1911:30 am -
2 stops10h 41m
Sat 2/276:30 am -
1 stop4h 58m
Deal found 10/21![United Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/17:13 am -
1 stop5h 48m
Mon 4/53:17 pm -
1 stop7h 33m
Deal found 10/25![American Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:00 am -
2 stops10h 01m
Tue 11/105:40 am -
2 stops16h 01m
Deal found 10/23![United Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:00 am -
2 stops8h 12m
Sat 1/212:13 pm -
2 stops10h 25m
Deal found 10/22![American Airlines logo]()
$666
Last-minute flights from Missouri to GreenvilleDiscover last-minute flight deals from Missouri to Greenville. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Greenville. Data last updated October 26, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
1 stop4h 15m
Wed 11/116:45 pm -
1 stop4h 15m
Deal found 10/23![Southwest logo]()
$390
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:54 pm -
1 stop5h 18m
Wed 11/117:00 am -
1 stop5h 05m
Deal found 10/21![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 am -
1 stop4h 27m
Fri 11/135:40 am -
1 stop4h 45m
Deal found 10/21![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 am -
1 stop6h 35m
Sun 11/155:40 am -
1 stop4h 47m
Deal found 10/21![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:36 am -
1 stop4h 54m
Mon 11/165:12 pm -
1 stop6h 18m
Deal found 10/21![United Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:35 pm -
1 stop3h 52m
Wed 11/1810:52 am -
1 stop7h 12m
Deal found 10/21![American Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:35 am -
1 stop5h 31m
Sun 11/157:02 am -
1 stop4h 51m
Deal found 10/21![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:30 pm -
1 stop5h 23m
Fri 11/205:40 am -
1 stop4h 20m
Deal found 10/26![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:56 am -
1 stop4h 16m
Mon 11/306:27 pm -
1 stop6h 34m
Deal found 10/21![American Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:47 pm -
1 stop21h 30m
Tue 11/243:51 pm -
1 stop23h 34m
Deal found 10/23![Allegiant Air logo]()
$356
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:10 am -
1 stop5h 05m
Fri 11/275:40 am -
1 stop6h 25m
Deal found 10/23![Delta logo]()
$366
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:00 am -
1 stop7h 58m
Fri 11/277:45 pm -
1 stop5h 39m
Deal found 10/25![American Airlines logo]()
$397
One-way flights from Missouri to GreenvilleSearch for one-way flight options from Missouri to Greenville. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
Search for one-way flight options from Missouri to Greenville. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:05 am -
1 stop4h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Southwest logo]()
$140
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:11 am -
1 stop5h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![American Airlines logo]()
$141
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/95:45 am -
2 stops10h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:32 pm -
3 stops46h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$198
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:30 am -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/811:01 am -
1 stop26h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$206
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1912:35 pm -
2 stops9h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/241:45 pm -
1 stop4h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/198:51 pm -
3 stops46h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:11 pm -
1 stop21h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Allegiant Air logo]()
$257
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:30 am -
1 stop3h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:13 pm -
1 stop17h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Allegiant Air logo]()
$283
Find flight deals from Missouri to Greenville
Keep the following information in mind while searching for Missouri to Greenville flight deals. Data was last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $263 (Southwest) |
One-way from | $140 (Southwest) |
Popular in | February |
Cheapest in | September |
Average price | $576 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from Missouri to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Sat 12/19
6:30 pm-11:59 pm
1 stop4h 29m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$140
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Wed 12/9
5:45 am-4:53 pm
2 stops10h 08m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Sun 11/22
8:30 am-4:10 pm
1 stop6h 40m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$199
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Sat 12/19
12:35 pm-11:05 pm
2 stops9h 30m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$207
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Wed 3/24
1:45 pm-7:05 pm
1 stop4h 20m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Sat 12/19
8:51 pm-8:12 pm
3 stops46h 21m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$239
SpringfieldGreenville
SGF Springfield-Branson - GSP Greenville
SGFGSP
Springfield-Branson
Tue 11/24
3:11 pm-1:43 pm
1 stop21h 32m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$257
Quickest round-trip
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Wed 11/4
6:30 am-11:19 am
1 stop3h 49m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$259
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Sun 11/8
1:37 pm-3:29 pm
3 stops48h 52m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$266
SpringfieldGreenville
SGF Springfield-Branson - GSP Greenville
SGFGSP
Springfield-Branson
Wed 12/23
8:13 pm-2:38 pm
1 stop17h 25m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$283
Showing 1-10 of 41 resultsSorted by cheapest first
Best time to book a flight from Missouri to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Missouri with our price prediction graph.
MCI-GSP
SGF-GSP
STL-GSP
COU-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Greenville
USMO-GSP
MCI-GSP
SGF-GSP
STL-GSP
COU-GSP
What is the cheapest month to book a flight from Missouri to Greenville?
Currently, September is the cheapest month in which you can book a flight from Missouri to Greenville (average of $293). Flying from Missouri to Greenville in May is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Greenville?
Airfare is below average for this route at the moment.
Missouri to Greenville flights typically cost between $325 and $590 in December.The cheapest round-trip price found within the last 5 days was $263 on Southwest (Dec 4-Dec 7).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Greenville
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Complete your trip
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Search flights from Missouri to Greenville by cabin class
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Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Missouri and Greenville flights
Browse other Missouri and Greenville flight options. Last updated on October 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Greenville flights
Consider these flights traveling from Missouri to Greenville.
Top 3 airlines flying from Missouri to Greenville
Discover the top 3 airlines that operate flights from Missouri to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$422 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$387 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$258 | Average$422 | FlexibilityNo cancel fee | On-time63% |