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$105+ Cheap flights from Missouri to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GSP
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Missouri to Greenville

Keep the following information in mind while searching for Missouri to Greenville flight deals. Data was last updated August 14, 2025.

Round-trip from

$209
(American Airlines)

One-way from

$105
(American Airlines)

Popular in

January

Cheapest in

August

Average price

$302
From Missouri to Greenville
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One-way flight from Missouri to Greenville
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Highest demand for flights based on searches. 18% potential increase in price ($93 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Missouri to Greenville

Cheapest flights from Missouri to Greenville
Explore the most affordable flight options available from Missouri to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/91:21 pmSTL - GSP
1 stop4h 53mAmerican Airlines
Tue 9/165:30 pmGSP - STL
1 stop5h 52mAmerican Airlines
Deal found 8/12$209
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:00 amMCI - GSP
1 stop8h 00mUnited Airlines
Wed 9/175:52 pmGSP - MCI
1 stop6h 33mUnited Airlines
Deal found 8/12$209
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amSTL - GSP
1 stop3h 56mAmerican Airlines
Tue 10/148:04 pmGSP - STL
1 stop4h 50mAmerican Airlines
Deal found 8/14$223
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:05 pmMCI - GSP
1 stop6h 50mSouthwest
Thu 10/28:00 pmGSP - MCI
1 stop5h 10mSouthwest
Deal found 8/13$223
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/12:15 pmSTL - GSP
1 stop4h 40mSouthwest
Wed 10/86:05 amGSP - STL
2 stops8h 45mSouthwest
Deal found 8/14$228
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/151:26 pmSTL - GSP
1 stop5h 59mDelta
Thu 9/186:35 amGSP - STL
1 stop4h 24mDelta
Deal found 8/13$237
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/92:15 pmSTL - GSP
1 stop4h 40mSouthwest
Tue 9/163:25 pmGSP - STL
2 stops7h 40mSouthwest
Deal found 8/12$242
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/87:05 amSTL - GSP
1 stop4h 45mDelta
Fri 10/105:30 amGSP - STL
1 stop3h 37mDelta
Deal found 8/13$244
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/145:32 amMCI - GSP
1 stop5h 25mAmerican Airlines
Wed 9/176:33 pmGSP - MCI
1 stop5h 34mAmerican Airlines
Deal found 8/14$245
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:00 amSTL - GSP
1 stop5h 20mDelta
Sun 9/75:30 amGSP - STL
1 stop4h 45mDelta
Deal found 8/13$254
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/53:36 pmSTL - GSP
1 stop4h 35mDelta
Fri 9/1211:24 amGSP - STL
1 stop6h 13mDelta
Deal found 8/14$271
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/58:10 amSTL - GSP
2 stops9h 42mUnited Airlines
Fri 9/124:59 pmGSP - STL
1 stop6h 09mUnited Airlines
Deal found 8/14$276

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Missouri to Greenville that are best for you.

Fly from

Missouri

Fly to

Greenville

Route

Depart

Return

Price

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 9/9

1:21 pm-7:14 pm

1 stop4h 53m

Greenville

Tue 9/16

5:30 pm-10:22 pm

1 stop5h 52m

$209

Kansas CityGreenville

MCI - GSP

MCIGSP

Kansas City

Wed 9/10

6:00 am-3:00 pm

1 stop8h 00m

Greenville

Wed 9/17

5:52 pm-11:25 pm

1 stop6h 33m

$209

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 10/1

6:29 am-1:42 pm

1 stop6h 13m

Greenville

Wed 10/8

4:46 pm-11:56 pm

1 stop8h 10m

$209

Kansas CityGreenville

MCI - GSP

MCIGSP

Kansas City

Wed 9/10

5:32 am-11:46 am

1 stop5h 14m

Greenville

Wed 9/17

6:33 pm-11:07 pm

1 stop5h 34m

$209

Kansas CityGreenville

MCI - GSP

MCIGSP

Kansas City

Wed 10/1

12:05 pm-7:55 pm

1 stop6h 50m

Greenville

Thu 10/2

8:00 pm-12:10 am

1 stop5h 10m

$223

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/11

8:49 am-5:05 pm

1 stop7h 16m

Greenville

Tue 10/14

5:52 pm-10:55 pm

1 stop6h 03m

$223

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 10/1

2:15 pm-7:55 pm

1 stop4h 40m

Greenville

Wed 10/8

6:05 am-1:50 pm

2 stops8h 45m

$228

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Mon 9/15

1:26 pm-8:25 pm

1 stop5h 59m

Greenville

Thu 9/18

6:35 am-9:59 am

1 stop4h 24m

$237

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 9/9

2:15 pm-7:55 pm

1 stop4h 40m

Greenville

Tue 9/16

3:25 pm-10:05 pm

2 stops7h 40m

$242

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 10/8

7:05 am-12:50 pm

1 stop4h 45m

Greenville

Fri 10/10

5:30 am-8:07 am

1 stop3h 37m

$244

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 36 results
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Best time to book a flight from Missouri to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Greenville

What is the cheapest month to book a flight from Missouri to Greenville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Greenville (average of $329). Flying from Missouri to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to GSP?

Find hourly flight availability from Missouri to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Greenville as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Missouri?

    Most people fly into Greenville (GSP) if they book a flight to Greenville from Missouri. Greenville is conveniently located just 10.4 mi from Greenville’s city center.

  • What are the cheapest airlines to fly from Missouri to Greenville one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $105. Delta flights start at $119 while deals on Southwest start at $124 one-way.

  • What are the most popular routes from Missouri to Greenville?

    The most popular flight routes from Missouri to Greenville are Lambert-St Louis - Greenville, Kansas City - Greenville and Springfield-Branson - Greenville.

  • Can I find deals for flights from Missouri to Greenville that include hotel bookings?

    Yes. In addition to deals on Missouri to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Greenville.

  • Can I find deals for business class flights from Missouri to Greenville?

    Yes. Cheapflights offers flight deals from Missouri to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Greenville (average of $329). Flying from Missouri to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 4 airlines flying from Missouri to Greenville

Discover the top 4 airlines that operate flights from Missouri to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$384FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$412FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$243Average$381FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$326Average$396FlexibilityNo cancel feeOn-time63%

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