HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$132+ Cheap flights from Iowa to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Greenville

Keep the following information in mind while searching for Iowa to Greenville flight deals. Data was last updated November 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$284
(Delta)

One-way from

$132
(Kiwi.com)

Popular in

January

Cheapest in

September

Average price

$581
Provider with most accurate pricing for Des Moines-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
Search Deals
From Iowa to Greenville
Search Deals
One-way flight from Iowa to Greenville
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Iowa to Greenville

Cheapest flights from Iowa to Greenville
Explore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This Delta deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:08 pmMLI - GSP
1 stop5h 32mDelta
Sun 12/147:36 pmGSP - MLI
1 stop3h 57mDelta
Deal found 11/14$249
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/212:22 pmCID - GSP
2 stops10h 18mDelta
Sat 12/65:17 pmGSP - CID
1 stop6h 02mDelta
Deal found 11/17$284
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2511:02 amMLI - GSP
1 stop7h 25mAmerican Airlines
Wed 12/34:35 pmGSP - MLI
1 stop7h 24mAmerican Airlines
Deal found 11/16$309
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:15 amOMA - GSP
1 stop6h 05mAmerican Airlines
Tue 12/28:14 pmGSP - OMA
1 stop4h 45mAmerican Airlines
Deal found 11/16$314
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:25 pmOMA - GSP
1 stop4h 24mUnited Airlines
Sat 12/65:28 pmGSP - OMA
1 stop5h 19mUnited Airlines
Deal found 11/17$317
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:17 pmDSM - GSP
1 stop5h 47mDelta
Sat 12/67:59 amGSP - DSM
1 stop7h 13mDelta
Deal found 11/17$317
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:17 pmDSM - GSP
2 stops7h 42mUnited Airlines
Sat 12/65:28 pmGSP - DSM
1 stop5h 09mUnited Airlines
Deal found 11/17$322
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:52 amMLI - GSP
2 stops12h 05mAmerican Airlines
Sun 12/148:14 pmGSP - MLI
1 stop4h 33mAmerican Airlines
Deal found 11/14$324
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:06 pmDSM - GSP
2 stops6h 40mAmerican Airlines
Sat 12/65:25 amGSP - DSM
2 stops7h 17mAmerican Airlines
Deal found 11/17$327
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/243:35 pmMLI - GSP
1 stop7h 49mAmerican Airlines
Mon 12/18:14 pmGSP - MLI
1 stop4h 26mAmerican Airlines
Deal found 11/17$338
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:52 pmCID - GSP
1 stop4h 57mUnited Airlines
Sat 12/65:28 pmGSP - CID
1 stop4h 51mUnited Airlines
Deal found 11/17$349
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:56 pmMLI - GSP
1 stop3h 53mUnited Airlines
Sat 12/65:28 pmGSP - MLI
1 stop4h 48mUnited Airlines
Deal found 11/16$349

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Iowa to Greenville that are best for you.

Fly from

Iowa

Fly to

Greenville

Route

Depart

Return

Price

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Sat 12/13

5:08 pm-11:41 pm

1 stop5h 33m

Greenville

Sun 12/14

7:36 pm-10:33 pm

1 stop3h 57m

$249

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Fri 12/12

5:08 pm-11:40 pm

1 stop5h 32m

Greenville

Sun 12/14

7:36 pm-10:33 pm

1 stop3h 57m

$249

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Sat 12/13

5:08 pm-11:41 pm

1 stop5h 33m

Greenville

Mon 12/15

7:36 pm-10:33 pm

1 stop3h 57m

$249

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Fri 12/12

5:08 pm-10:33 pm

1 stop4h 25m

Greenville

Mon 12/15

7:36 pm-10:33 pm

1 stop3h 57m

$249

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Tue 12/2

12:22 pm-11:40 pm

2 stops10h 18m

Greenville

Sat 12/6

5:17 pm-10:19 pm

1 stop6h 02m

$284

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Fri 11/28

3:35 pm-11:55 pm

1 stop7h 20m

Greenville

Tue 12/2

8:14 pm-11:40 pm

1 stop4h 26m

$309

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Mon 1/5

10:47 am-11:56 pm

2 stops12h 09m

Greenville

Tue 2/3

10:51 am-4:54 pm

1 stop7h 03m

$312

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Tue 12/2

3:25 pm-8:49 pm

1 stop4h 24m

Greenville

Sat 12/6

5:28 pm-9:47 pm

1 stop5h 19m

$317

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Tue 12/2

6:12 pm-11:40 pm

1 stop4h 28m

Greenville

Sat 12/6

5:35 am-10:11 am

1 stop5h 36m

$317

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 12/2

3:17 pm-10:04 pm

1 stop5h 47m

Greenville

Sat 12/6

7:59 am-2:12 pm

1 stop7h 13m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 40 results
1
2
3
4

Best time to book a flight from Iowa to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Greenville

What is the cheapest month to book a flight from Iowa to Greenville?

Currently, September is the cheapest month in which you can book a flight from Iowa to Greenville (average of $198). Flying from Iowa to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Iowa?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly into when you book flights from Iowa to Greenville.

  • How long is the flight from Iowa to Greenville?

    There are many flights that can get you from Iowa to Greenville in 4h 24m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. There are 863 mi between Iowa and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Greenville one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $132. Users have also found prices from $159 and $274 on Delta and United Airlines, respectively.

  • What are the most popular routes from Iowa to Greenville?

    When deciding which route to take from Iowa to Greenville consider Cedar Rapids - Greenville, Moline Quad-City - Greenville or Des Moines - Greenville as they are the most popular.

  • Can I find deals for flights from Iowa to Greenville that include hotel bookings?

    Yes. In addition to deals on Iowa to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Greenville.

  • Can I find deals for business class flights from Iowa to Greenville?

    Yes. Cheapflights offers flight deals from Iowa to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Greenville?

    Currently, September is the cheapest month in which you can book a flight from Iowa to Greenville (average of $198). Flying from Iowa to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Charlotte flights
Newark to Charlotte flights
Boston to Charlotte flights
LaGuardia to Charlotte flights
LaGuardia to Charleston flights
John F Kennedy Intl to Savannah flights
Denver to Charlotte flights
Newark to Charleston flights
Dallas/Fort Worth to Charlotte flights
John F Kennedy Intl to Charleston flights
O'Hare Intl to Charlotte flights
O'Hare Intl to Charleston flights
Boston to Charleston flights
Newark to Savannah flights
Hobby to Charlotte flights
Dulles Intl to Charlotte flights
Boston to Savannah flights
LaGuardia to Savannah flights
O'Hare Intl to Savannah flights
Los Angeles to Charlotte flights
Seattle to Charlotte flights
George Bush Intcntl to Charlotte flights
Fort Lauderdale to Charlotte flights
Reagan-National to Charlotte flights
Baltimore to Charlotte flights
Philadelphia to Charlotte flights
San Francisco to Charlotte flights
Philadelphia to Charleston flights
Newark to Greenville flights
John F Kennedy Intl to Myrtle Beach flights
Minneapolis to Charleston flights
Minneapolis to Charlotte flights
Dulles Intl to Savannah flights
Newark to Myrtle Beach flights
Dulles Intl to Charleston flights
LaGuardia to Myrtle Beach flights
Cleveland to Charlotte flights
Baltimore to Charleston flights
Denver to Charleston flights
Detroit to Charlotte flights
Reagan-National to Charleston flights
Sky Harbor Intl to Charlotte flights
Salt Lake City to Charlotte flights
Love Field to Charlotte flights
Denver to Savannah flights
Miami to Charlotte flights
Dallas/Fort Worth to Charleston flights
LaGuardia to Columbia flights
Detroit to Charleston flights
LaGuardia to Greenville flights

Top 3 airlines flying from Iowa to Greenville

Discover the top 3 airlines that operate flights from Iowa to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$413FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$386FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$271Average$477FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.