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$161+ Cheap flights from Iowa to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Oct 30 — Nov 61
Thu 10/30
Thu 11/6
1 adult, Economy
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Cheap flight deals from Iowa to Greenville

Keep the following information in mind while searching for Iowa to Greenville flight deals. Data was last updated September 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$161
(Kiwi.com)

Popular in

November

Cheapest in

June

Average price

$335
Provider with most accurate pricing for Des Moines-Greenville flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
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From Iowa to Greenville
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One-way flight from Iowa to Greenville
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Highest demand for flights based on searches. 12% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Iowa to Greenville

Cheapest flights from Iowa to Greenville
Explore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2025.

This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amCID - GSP
1 stop5h 47mDelta
Sat 11/85:16 pmGSP - CID
1 stop6h 18mDelta
Deal found 9/30$249
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:46 amDSM - GSP
1 stop8h 47mDelta
Wed 11/1910:07 amGSP - DSM
1 stop4h 25mDelta
Deal found 9/28$251
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:15 pmDSM - GSP
1 stop5h 40mDelta
Tue 10/286:35 amGSP - DSM
1 stop4h 30mDelta
Deal found 9/28$254
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amCID - GSP
1 stop5h 47mDelta
Tue 11/115:35 amGSP - CID
2 stops7h 13mDelta
Deal found 9/30$254
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:30 amMLI - GSP
1 stop6h 06mUnited Airlines
Wed 10/229:35 amGSP - MLI
1 stop6h 30mUnited Airlines
Deal found 9/29$254
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:19 pmDSM - GSP
2 stops7h 41mAmerican Airlines
Wed 11/1912:06 pmGSP - DSM
1 stop5h 15mAmerican Airlines
Deal found 9/28$256
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:07 amDSM - GSP
1 stop5h 57mAmerican Airlines
Tue 10/286:00 amGSP - DSM
2 stops7h 19mAmerican Airlines
Deal found 9/28$259
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:55 pmCID - GSP
1 stop5h 29mAmerican Airlines
Fri 11/2810:55 amGSP - CID
1 stop5h 05mAmerican Airlines
Deal found 9/28$279
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:38 pmOMA - GSP
1 stop6h 05mAmerican Airlines
Fri 10/316:11 amGSP - OMA
1 stop7h 49mAmerican Airlines
Deal found 9/30$283
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/182:17 pmDSM - GSP
1 stop6h 08mDelta
Mon 11/246:45 amGSP - DSM
1 stop4h 57mDelta
Deal found 9/30$283
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/187:46 amDSM - GSP
1 stop8h 47mDelta
Tue 11/255:35 amGSP - DSM
1 stop6h 07mDelta
Deal found 9/30$284
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:38 pmCID - GSP
1 stop4h 17mDelta
Thu 11/135:35 amGSP - CID
2 stops7h 13mDelta
Deal found 9/30$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 30, 2025.
Use the filters below to find and compare flights from Iowa to Greenville that are best for you.

Fly from

Iowa

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 11/12

7:46 am-5:33 pm

1 stop8h 47m

Greenville

Wed 11/19

10:07 am-1:32 pm

1 stop4h 25m

$251

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Wed 10/15

6:30 am-1:36 pm

1 stop6h 06m

Greenville

Wed 10/22

9:35 am-3:05 pm

1 stop6h 30m

$254

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 10/25

5:15 pm-11:55 pm

1 stop5h 40m

Greenville

Tue 10/28

6:35 am-10:05 am

1 stop4h 30m

$254

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Tue 11/4

6:00 am-12:47 pm

1 stop5h 47m

Greenville

Wed 11/12

5:35 am-11:48 am

2 stops7h 13m

$254

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Tue 11/4

6:00 am-12:47 pm

1 stop5h 47m

Greenville

Tue 11/11

5:35 am-11:48 am

2 stops7h 13m

$254

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 11/12

2:19 pm-11:00 pm

2 stops7h 41m

Greenville

Wed 11/19

12:06 pm-4:21 pm

1 stop5h 15m

$256

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Sat 11/8

6:00 am-5:41 pm

2 stops10h 41m

Greenville

Thu 11/13

5:35 am-11:48 am

2 stops7h 13m

$259

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Mon 11/24

6:00 am-10:58 am

1 stop3h 58m

Greenville

Fri 11/28

10:55 am-3:00 pm

1 stop5h 05m

$279

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Wed 10/29

1:38 pm-8:43 pm

1 stop6h 05m

Greenville

Fri 10/31

6:11 am-1:00 pm

1 stop7h 49m

$283

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 11/19

7:48 am-2:44 pm

1 stop5h 56m

Greenville

Mon 11/24

11:42 am-4:19 pm

1 stop5h 37m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/28

Showing 1-10 of 56 results
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Best time to book a flight from Iowa to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Greenville

What is the cheapest month to book a flight from Iowa to Greenville?

Currently, August is the cheapest month in which you can book a flight from Iowa to Greenville (average of $321). Flying from Iowa to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to GSP?

Find hourly flight availability from Iowa to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 30, 2025.

When flying from Iowa to Greenville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Iowa?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly into when you book flights from Iowa to Greenville.

  • How long is the flight from Iowa to Greenville?

    There are many flights that can get you from Iowa to Greenville in 6h 06m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. There are 637 mi between Iowa and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Greenville one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $161. Users have also found prices from $194 and $194 on Delta and United Airlines, respectively.

  • What are the most popular routes from Iowa to Greenville?

    When deciding which route to take from Iowa to Greenville consider Des Moines - Greenville, Cedar Rapids - Greenville or Omaha Eppley Airfield - Greenville as they are the most popular.

  • Can I find deals for flights from Iowa to Greenville that include hotel bookings?

    Yes. In addition to deals on Iowa to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Greenville.

  • Can I find deals for business class flights from Iowa to Greenville?

    Yes. Cheapflights offers flight deals from Iowa to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Greenville (average of $321). Flying from Iowa to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 3 airlines flying from Iowa to Greenville

Discover the top 3 airlines that operate flights from Iowa to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$412FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$389FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$271Average$477FlexibilityNo cancel feeOn-time69%

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