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$228+ Cheap flights from Knoxville to Gainesville (TYS - GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GNV
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$387
(Delta)

One-way from

$228
(Delta)

Popular in

October

Cheapest in

September

Average price

$263
From Knoxville McGhee Tyson to Gainesville Regional
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One-way flight from Knoxville McGhee Tyson to Gainesville Regional
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Highest demand for flights based on searches. 6% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Gainesville

Cheapest flights from Knoxville to Gainesville
Explore the most affordable flight options available from Knoxville to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:45 amTYS - GNV
1 stop3h 40mDelta
Sun 9/281:16 pmGNV - TYS
1 stop3h 47mDelta
Deal found 9/10$387
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:05 amTYS - GNV
1 stop4h 54mDelta
Mon 10/133:44 pmGNV - TYS
1 stop3h 21mDelta
Deal found 9/10$423
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:43 pmTYS - GNV
1 stop3h 43mAmerican Airlines
Mon 10/277:44 pmGNV - TYS
1 stop4h 06mAmerican Airlines
Deal found 9/10$453
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:25 amTYS - GNV
1 stop3h 59mDelta
Sun 12/1410:11 amGNV - TYS
1 stop4h 40mDelta
Deal found 9/10$459
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:00 amTYS - GNV
1 stop5h 09mAmerican Airlines
Sat 10/119:18 amGNV - TYS
1 stop5h 09mAmerican Airlines
Deal found 9/10$493
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:07 pmTYS - GNV
1 stop6h 52mAmerican Airlines
Sun 11/238:00 pmGNV - TYS
1 stop3h 51mAmerican Airlines
Deal found 9/11$523
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:25 amTYS - GNV
1 stop4h 01mDelta
Sun 11/307:04 pmGNV - TYS
1 stop4h 48mDelta
Deal found 9/10$692

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Gainesville that are best for you.

Fly from

Knoxville

Fly to

Gainesville

Route

Depart

Return

Price

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/26

5:45 am-9:25 am

1 stop3h 40m

Gainesville Regional

Sun 9/28

1:16 pm-5:03 pm

1 stop3h 47m

$387

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/10

10:05 am-2:59 pm

1 stop4h 54m

Gainesville Regional

Sun 10/12

7:07 pm-11:46 pm

1 stop4h 39m

$423

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/10

10:05 am-2:59 pm

1 stop4h 54m

Gainesville Regional

Mon 10/13

3:44 pm-7:05 pm

1 stop3h 21m

$423

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/24

8:15 am-2:19 pm

1 stop6h 04m

Gainesville Regional

Mon 10/27

7:44 pm-11:50 pm

1 stop4h 06m

$453

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Wed 10/8

5:00 am-10:09 am

1 stop5h 09m

Gainesville Regional

Sat 10/11

6:00 am-12:27 pm

2 stops6h 27m

$498

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 11/21

5:07 pm-11:59 pm

1 stop6h 52m

Gainesville Regional

Sun 11/23

8:00 pm-11:51 pm

1 stop3h 51m

$523

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Tue 11/25

5:25 am-9:26 am

1 stop4h 01m

Gainesville Regional

Sun 11/30

7:04 pm-11:52 pm

1 stop4h 48m

$692

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-11:10 pm

1 stop3h 11m

$228

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/10

8:37 pm-12:17 am

1 stop3h 40m

$228

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Thu 10/9

8:37 pm-12:17 am

1 stop3h 40m

$228

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 16 results
1
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Best time to book a flight from Knoxville to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Gainesville

What is the cheapest month to book a flight from Knoxville to Gainesville?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Gainesville (average of $359). Flying from Knoxville to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to GNV?

Find hourly flight availability from Knoxville to Gainesville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Knoxville to Gainesville in the morning. By choosing this option you can save up to 3% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Gainesville

Get insights into the airlines that provide service to Gainesville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Gainesville. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta and American Airlines from Knoxville to Gainesville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Gainesville?

    For as low as $387, Delta can have you in Gainesville from Knoxville in 3h 40m. There are 434 mi between Knoxville and Gainesville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Gainesville round-trip?

    According to our current data, Delta ($228), and American Airlines ($268) offers the cheapest pricing from Knoxville to Gainesville. Delta is priced at 51% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to Gainesville that include hotel bookings?

    Yes. In addition to deals on Knoxville to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Gainesville.

  • Can I find deals for business class flights from Knoxville to Gainesville?

    Yes. Cheapflights offers flight deals from Knoxville to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Gainesville?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Gainesville (average of $359). Flying from Knoxville to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Top 2 airlines flying from Knoxville to Gainesville

Discover the top 2 airlines that operate flights from Knoxville to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$228Average$488FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$657FlexibilityNo cancel feeOn-time71%

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