What are the cheapest airlines flying from Des Moines to Fort Myers round-trip?

Cheapflights users have booked flights from Des Moines to Fort Myers round-trip from $285. Other airlines that can offer you cheap pricing are American Airlines, from $290, and Southwest, from $357. Delta is currently priced 29% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Des Moines to Fort Myers one-way?

One-way options have recently been found by users for as low as $143 on Southwest. Other airlines that offer cheap prices include American Airlines from $148 and Delta from $224 one-way.

What is the cheapest day to fly from Des Moines to Fort Myers?

Travelers seeking maximum savings on their Des Moines to Fort Myers flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Des Moines to Fort Myers?

When booking a flight from Des Moines to Fort Myers, you may want to consider flying on American Airlines, Delta or Allegiant Air as they are the most popular for this route.

What is the cheapest day to fly round-trip from Des Moines to Fort Myers?

Flying to your destination on a Saturday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Fort Myers. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from Des Moines to Fort Myers?

Users have found that booking a flight from Des Moines to Fort Myers at least 10 days early can save you up to 5% on average compared to booking a flight this week. If booking 10 days before your flight isn’t an option for you, users have found flights from Des Moines to Fort Myers for as little as $296 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $812 for flights departing within the next 3 days.

What is the cheapest month to fly from Des Moines to Fort Myers?

August can be a great time to fly to Fort Myers from Des Moines with a flight ticket averaging about $402. Cheapflights users have found deals in the month of August for as cheap as $271. The most expensive prices can be found in the month of March.

Can I find deals for flights from Des Moines to Fort Myers that include hotel bookings?

Yes. In addition to deals on Des Moines to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Fort Myers?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Fort Myers.

Can I find deals for business class flights from Des Moines to Fort Myers?

Yes. Cheapflights offers flight deals from Des Moines to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$143+ Flights from Des Moines to Fort Myers

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to Fort Myers with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Fort Myers SW Florida Intl are usually found in August or September, booked 87 days in advance, depart on a Tuesday or Wednesday and return on a Friday

Cheap flight deals from Des Moines to Fort Myers

Round-trip from	$285 (Delta)
One-way from	$143 (Southwest)
Popular in	March
Cheapest in	August
Average price	$383

From Des Moines to Fort Myers SW Florida Intl

Search Deals

One-way flight from Des Moines to Fort Myers SW Florida Intl

Search Deals

Highest demand for flights based on searches. 15% potential increase in price ($74 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in June 2025

Search Deals

Find flight deals from Des Moines to Fort Myers

Cheapest flights from Des Moines to Fort Myers
Explore the most affordable flight options available from Des Moines to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

mar. 8/262:12 pmDSM - RSW

1 stop6h 05mDelta

mar. 9/26:32 amRSW - DSM

1 stop8h 37mDelta

Deal found 6/10

$285

mar. 8/265:12 amDSM - RSW

2 stops11h 26mAmerican Airlines

mar. 9/211:03 amRSW - DSM

1 stop6h 45mAmerican Airlines

Deal found 6/11

$290

dom. 9/73:42 pmDSM - RSW

2 stops19h 53mMultiple Airlines

mié. 9/107:55 pmRSW - DSM

3 stops22h 04mMultiple Airlines

Deal found 6/9

$334

vie. 11/76:15 pmDSM - RSW

1 stop4h 20mSouthwest

vie. 11/147:30 amRSW - DSM

1 stop4h 30mSouthwest

Deal found 6/10

$357

mar. 8/56:24 amDSM - RSW

1 stop7h 38mUnited Airlines

jue. 8/74:36 pmRSW - DSM

1 stop6h 11mUnited Airlines

Deal found 6/10

$365

Best flights from Des Moines to Fort Myers
Discover carefully curated flight deals from Des Moines to Fort Myers that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 12, 2025.

mar. 8/262:12 pmDSM - RSW

1 stop6h 05mDelta

mar. 9/26:32 amRSW - DSM

1 stop8h 37mDelta

Deal found 6/10

$285

mar. 8/265:12 amDSM - RSW

2 stops11h 26mAmerican Airlines

mar. 9/211:03 amRSW - DSM

1 stop6h 45mAmerican Airlines

Deal found 6/11

$290

dom. 9/73:42 pmDSM - RSW

2 stops19h 53mMultiple Airlines

mié. 9/107:55 pmRSW - DSM

3 stops22h 04mMultiple Airlines

Deal found 6/9

$334

vie. 11/76:15 pmDSM - RSW

1 stop4h 20mSouthwest

vie. 11/147:30 amRSW - DSM

1 stop4h 30mSouthwest

Deal found 6/10

$357

mar. 8/56:24 amDSM - RSW

1 stop7h 38mUnited Airlines

jue. 8/74:36 pmRSW - DSM

1 stop6h 11mUnited Airlines

Deal found 6/10

$365

Last-minute flights from Des Moines to Fort Myers
Discover last-minute flight deals from Des Moines to Fort Myers. Data last updated junio 12, 2025 and is based on user searches.

vie. 6/206:00 amDSM - RSW

2 stops36h 04mMultiple Airlines

mié. 6/258:09 pmRSW - DSM

2 stops27h 28mMultiple Airlines

Deal found 6/10

$504

vie. 6/208:00 amDSM - RSW

1 stop26h 35mUnited Airlines

mié. 6/2512:14 pmRSW - DSM

1 stop6h 45mUnited Airlines

Deal found 6/10

$621

vie. 6/206:25 amDSM - RSW

2 stops11h 10mSouthwest

mié. 6/257:25 pmRSW - DSM

1 stop4h 50mSouthwest

Deal found 6/10

$632

dom. 6/226:10 amDSM - RSW

2 stops8h 10mAmerican Airlines

mar. 6/248:03 amRSW - DSM

2 stops8h 07mAmerican Airlines

Deal found 6/11

$802

vie. 6/276:00 amDSM - RSW

1 stop8h 24mUnited Airlines

mar. 7/16:00 amRSW - DSM

2 stops9h 41mUnited Airlines

Deal found 6/12

$387

jue. 7/35:25 amDSM - RSW

2 stops13h 55mSouthwest

dom. 7/66:00 amRSW - DSM

2 stops12h 55mSouthwest

Deal found 6/11

$499

sáb. 7/261:13 pmDSM - RSW

2 stops28h 12mMultiple Airlines

sáb. 8/25:58 pmRSW - DSM

2 stops29h 40mMultiple Airlines

Deal found 6/11

$414

mié. 7/302:39 pmDSM - RSW

1 stop7h 23mDelta

mar. 8/58:21 amRSW - DSM

1 stop6h 18mDelta

Deal found 6/12

$319

mié. 7/303:59 pmDSM - RSW

1 stop7h 43mAmerican Airlines

mar. 8/54:07 pmRSW - DSM

2 stops8h 37mAmerican Airlines

Deal found 6/11

$324

One-way flights from Des Moines to Fort Myers
Search for one-way flight options from Des Moines to Fort Myers. Find affordable one-way fares based on user searches. Data last updated junio 12, 2025.

jue. 10/95:35 amDSM - RSW

1 stop4h 30mSouthwest

Deal found 6/11

$143

lun. 7/142:00 pmDSM - RSW

2 stops29h 29mMultiple Airlines

Deal found 6/11

$145

mar. 8/126:00 amDSM - RSW

2 stops10h 38mAmerican Airlines

Deal found 6/10

$148

vie. 10/102:37 pmDSM - RSW

1 stop7h 21mDelta

Deal found 6/11

$224

mar. 10/2111:28 amDSM - RSW

3 stops27h 28mUnited Airlines

Deal found 6/10

$458

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

mar. 8/26

2:12 pm-9:17 pm

1 stop6h 05m

Fort Myers SW Florida Intl

mar. 9/2

6:32 am-2:09 pm

1 stop8h 37m

$285

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

mar. 8/26

5:12 am-5:38 pm

2 stops11h 26m

Fort Myers SW Florida Intl

mar. 9/2

11:03 am-4:48 pm

1 stop6h 45m

$290

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

dom. 9/7

3:42 pm-12:35 pm

2 stops19h 53m

Fort Myers SW Florida Intl

mié. 9/10

7:55 pm-4:59 pm

3 stops22h 04m

$334

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

vie. 11/7

6:15 pm-11:35 pm

1 stop4h 20m

Fort Myers SW Florida Intl

vie. 11/14

7:30 am-11:00 am

1 stop4h 30m

$357

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

mar. 8/5

6:24 am-3:02 pm

1 stop7h 38m

Fort Myers SW Florida Intl

jue. 8/7

4:36 pm-9:47 pm

1 stop6h 11m

$365

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

jue. 10/9

5:35 am-11:05 am

1 stop4h 30m

$143

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

lun. 7/14

2:00 pm-8:29 pm

2 stops29h 29m

$145

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

mar. 8/12

6:00 am-5:38 pm

2 stops10h 38m

$148

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

vie. 10/10

2:37 pm-10:58 pm

1 stop7h 21m

$224

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

mar. 10/21

11:28 am-3:56 pm

3 stops27h 28m

$458

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Des Moines to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Fort Myers

How far ahead should I book a flight from Des Moines to Fort Myers?

The price you pay for your flight from Des Moines to Fort Myers may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Fort Myers?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Fort Myers (average of $205). Flying from Des Moines to Fort Myers in June is currently the most expensive (average of $297). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to RSW?

A simple way to save on the total cost of your ticket is to fly from Des Moines to Fort Myers at noon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the morning.

Rainfall in Fort Myers by month

In terms of precipitation, rainfall in Fort Myers ranges from 1.7 - 10.1 inches per month. June is typically the wettest month, when rainfall can reach 10.1 in. December is typically the driest time to visit Fort Myers when rainfall is around 1.7 in.

Temperature in Fort Myers by month

If weather is an important factor for your trip to Fort Myers, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 64.4 F).

Reviews of airlines servicing Fort Myers

Read through reviews of airlines operating flights from Des Moines to Fort Myers, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,950 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Des Moines to Fort Myers round-trip?
Cheapflights users have booked flights from Des Moines to Fort Myers round-trip from $285. Other airlines that can offer you cheap pricing are American Airlines, from $290, and Southwest, from $357. Delta is currently priced 29% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Des Moines to Fort Myers one-way?
One-way options have recently been found by users for as low as $143 on Southwest. Other airlines that offer cheap prices include American Airlines from $148 and Delta from $224 one-way.
Can I find deals for flights from Des Moines to Fort Myers that include hotel bookings?
Yes. In addition to deals on Des Moines to Fort Myers flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Fort Myers?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Fort Myers.
Can I find deals for business class flights from Des Moines to Fort Myers?
Yes. Cheapflights offers flight deals from Des Moines to Fort Myers by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Fort Myers?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Fort Myers (average of $205). Flying from Des Moines to Fort Myers in June is currently the most expensive (average of $297). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

North Fort Myers

Sanibel

Estero

Lehigh Acres

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Des Moines to Fort Myers

Omaha to Orlando flights

Cedar Rapids to Orlando flights

Omaha to Miami flights

Omaha to Fort Lauderdale flights

Des Moines to Orlando flights

Moline to Orlando flights

Des Moines to Fort Lauderdale flights

Omaha to Tampa flights

Des Moines to Miami flights

Cedar Rapids to Sarasota flights

Cedar Rapids to Miami flights

Omaha to Panama City flights

Cedar Rapids to Fort Myers flights

Cedar Rapids to Tampa flights

Moline to Fort Myers flights

Des Moines to Key West flights

Moline to Tampa flights

Des Moines to Tampa flights

Moline to Miami flights

Des Moines to Sarasota flights

Omaha to Fort Myers flights

Moline to Pensacola flights

Omaha to Orlando Sanford Intl flights

Moline to Sarasota flights

Cedar Rapids to Jacksonville flights

Des Moines to West Palm Beach flights

Des Moines to Orlando Sanford Intl flights

Omaha to West Palm Beach flights

Omaha to Pensacola flights

Omaha to Jacksonville flights

Cedar Rapids to Pensacola flights

Cedar Rapids to Orlando Sanford Intl flights

Des Moines to Pensacola flights

Cedar Rapids to Fort Lauderdale flights

Moline to Key West flights

Omaha to Sarasota flights

Omaha to Key West flights

Cedar Rapids to Panama City flights

Des Moines to St Petersburg flights

Des Moines to Panama City flights

Cedar Rapids to Key West flights

Omaha to Valparaiso flights

Moline to St Petersburg flights

Cedar Rapids to St Petersburg flights

Cedar Rapids to Punta Gorda flights

Cedar Rapids to West Palm Beach flights

Des Moines to Valparaiso flights

Mason City to Orlando flights

Moline to Jacksonville flights

Complete your trip

Fort Myers car rentals

Fort Myers SW Florida Intl Airport car rentals

Sarasota Bradenton Intl Airport car rentals

Punta Gorda Airport car rentals

Naples Airport car rentals

Orlando car rentals

Miami car rentals

Fort Lauderdale car rentals

Tampa car rentals

Jacksonville car rentals

West Palm Beach car rentals

Pensacola car rentals

Top 5 airlines flying from Des Moines to Fort Myers

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$107	Average$296	FlexibilityNo cancel fee	On-time88%
United Airlines	Cheapest$276	Average$449	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$286	Average$405	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$306	Average$387	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$338	Average$464	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$143+ Cheap flights from Des Moines to Fort Myers (DSM - RSW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Fort Myers with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Fort Myers SW Florida Intl are usually found in August or September, booked 87 days in advance, depart on a Tuesday or Wednesday and return on a Friday

Cheap flight deals from Des Moines to Fort Myers

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Fort Myers

Cheapest flights from Des Moines to Fort MyersExplore the most affordable flight options available from Des Moines to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Explore the most affordable flight options available from Des Moines to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Fort Myers that are best for you.

Best time to book a flight from Des Moines to Fort Myers

Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Fort Myers

How far ahead should I book a flight from Des Moines to Fort Myers?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Fort Myers. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Des Moines to Fort Myers?

What is the cheapest time of day to fly from DSM to RSW?

Find hourly flight availability from Des Moines to Fort Myers. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Rainfall in Fort Myers by month

Plan your trip to Fort Myers by taking into account the average rainfall totals by month.

Temperature in Fort Myers by month

Plan your trip to Fort Myers by taking into account the average temperature totals by month.

Reviews of airlines servicing Fort Myers

Read through reviews of airlines operating flights from Des Moines to Fort Myers, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Fort Myers round-trip?

What are the cheapest airlines to fly from Des Moines to Fort Myers one-way?

Can I find deals for flights from Des Moines to Fort Myers that include hotel bookings?

How can I find direct flights from Des Moines to Fort Myers?

Can I find deals for business class flights from Des Moines to Fort Myers?

What is the cheapest month to book a flight from Des Moines to Fort Myers?

Traveling to a place near Des Moines?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Fort Myers

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Des Moines to Fort Myers

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Fort Myers
Explore the most affordable flight options available from Des Moines to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.