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Florida Keys

$37+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This Expedia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:00 am
CLT
-
MIA
Nonstop2h 10m
Spirit Airlines
Sat 3/710:05 am
MIA
-
CLT
Nonstop2h 15m
Spirit Airlines
Deal found 2/11$78
This Super.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/232:28 pm
CLT
-
MIA
Nonstop2h 17m
Frontier
Mon 4/2711:17 am
MIA
-
CLT
Nonstop2h 26m
Frontier
Deal found 2/12$79
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:28 pm
CLT
-
MIA
Nonstop2h 17m
Frontier
Mon 4/2711:17 am
MIA
-
CLT
Nonstop2h 26m
Frontier
Deal found 2/10$80
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:27 pm
CLT
-
MIA
Nonstop2h 16m
Frontier
Sat 3/77:40 am
MIA
-
CLT
Nonstop2h 17m
Frontier
Deal found 2/13$81
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:00 am
CLT
-
MIA
Nonstop2h 10m
Spirit Airlines
Fri 3/610:05 am
MIA
-
CLT
Nonstop2h 15m
Spirit Airlines
Deal found 2/11$82
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:42 am
CLT
-
MIA
Nonstop2h 15m
Frontier
Fri 4/310:00 pm
MIA
-
CLT
Nonstop2h 25m
Frontier
Deal found 2/10$83
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
CLT
-
MIA
Nonstop2h 02m
Spirit Airlines
Thu 4/99:57 am
MIA
-
CLT
Nonstop2h 10m
Spirit Airlines
Deal found 2/10$84
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:00 am
CLT
-
MIA
Nonstop2h 10m
Multiple Airlines
Fri 3/67:30 am
MIA
-
CLT
Nonstop2h 17m
Multiple Airlines
Deal found 2/10$85
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/309:47 pm
CLT
-
MIA
Nonstop2h 12m
Frontier
Mon 4/610:00 pm
MIA
-
CLT
Nonstop2h 25m
Frontier
Deal found 2/10$86
This Cheapflightsfares deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:00 am
CLT
-
MIA
Nonstop2h 10m
Spirit Airlines
Fri 2/2710:05 am
MIA
-
CLT
Nonstop2h 15m
Spirit Airlines
Deal found 2/10$87
This Frontier deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/201:37 pm
CLT
-
MIA
Nonstop2h 16m
Frontier
Thu 2/263:30 pm
MIA
-
CLT
Nonstop2h 20m
Frontier
Deal found 2/12$88
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/279:32 pm
CLT
-
MIA
Nonstop2h 12m
Frontier
Fri 4/310:00 pm
MIA
-
CLT
Nonstop2h 25m
Frontier
Deal found 2/10$89

Find flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$78
(Expedia)

One-way from

$37
(Super.com)

Popular in

June

Cheapest in

October

Average price

$386
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.
Search Deals
From South Carolina to Florida Keys
Search Deals
One-way flight from South Carolina to Florida Keys
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 3/8

7:00 am-9:10 am

Nonstop2h 10m

Miami

Wed 3/11

7:30 am-9:47 am

Nonstop2h 17m

$104

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Thu 3/5

2:21 pm-4:36 pm

Nonstop2h 15m

Miami

Tue 3/10

10:29 pm-8:11 am

1 stop9h 42m

$114

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sun 2/22

3:01 pm-12:26 pm

1 stop21h 25m

Key West

Fri 2/27

9:49 am-9:53 pm

1 stop12h 04m

$165

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Tue 3/3

7:00 am-9:10 am

Nonstop2h 10m

Miami

Sun 3/8

10:05 am-12:20 pm

Nonstop2h 15m

$168

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Fri 4/17

6:39 pm-3:09 pm

1 stop20h 30m

Miami

Sat 4/25

10:13 am-5:14 pm

1 stop7h 01m

$171

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sun 2/22

3:01 pm-12:26 pm

1 stop21h 25m

Key West

Thu 2/26

11:01 am-9:59 pm

1 stop10h 58m

$171

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 4/15

9:42 am-7:22 pm

1 stop9h 40m

Miami

Tue 4/21

10:55 am-5:48 pm

1 stop6h 53m

$174

AugustaMiami

AGS - MIA

AGSMIA

Augusta Bush Field

Sun 4/5

11:35 am-1:27 pm

Nonstop1h 52m

Miami

Mon 4/13

9:00 am-10:49 am

Nonstop1h 49m

$177

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Thu 4/16

9:42 am-7:22 pm

1 stop9h 40m

Miami

Mon 4/20

7:00 am-5:44 pm

1 stop10h 44m

$178

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sat 3/7

9:53 am-9:32 pm

1 stop11h 39m

Miami

Tue 3/10

12:52 pm-2:55 pm

1 stop26h 03m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $92). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $229). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Florida Keys?

    Departing from South Carolina to Florida Keys will take you 2h 10m. South Carolina and Florida Keys are separated by a distance of 652 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $31 on Spirit Airlines. Other airlines that offer cheap prices include Allegiant Air from $39 and American Airlines from $78 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $92). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $229). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Florida Keys

Discover the top 3 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$95Average$211FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$125Average$451FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$467FlexibilityNo cancel feeOn-time71%

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