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Florida Keys

$53+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated July 31, 2025.

Round-trip from

$110
(FlightHub)

One-way from

$53
(Frontier)

Popular in

March

Cheapest in

October

Average price

$346
From South Carolina to Florida Keys
Search Deals
One-way flight from South Carolina to Florida Keys
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Highest demand for flights based on searches. 13% potential increase in price ($51 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This FlightHub deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/301:43 pmCLT - MIA
Nonstop2h 05mMultiple Airlines
Sun 9/76:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Deal found 7/31$110
This Frontier deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/149:02 amCLT - MIA
Nonstop2h 23mFrontier
Sun 8/176:00 amMIA - CLT
Nonstop2h 17mFrontier
Deal found 7/31$111
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/161:43 pmCLT - MIA
Nonstop2h 05mSpirit Airlines
Thu 8/2110:23 amMIA - CLT
Nonstop2h 15mSpirit Airlines
Deal found 7/29$116
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/252:43 pmSAV - MIA
1 stop6h 45mDelta
Wed 9/34:25 pmMIA - SAV
1 stop5h 12mDelta
Deal found 7/31$149
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/129:00 pmCHS - EYW
1 stop12h 22mBreeze Airways
Fri 8/151:47 pmEYW - CHS
1 stop19h 27mBreeze Airways
Deal found 7/29$150
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:50 pmCLT - MIA
Nonstop2h 09mAmerican Airlines
Tue 9/25:18 amMIA - CLT
Nonstop2h 08mAmerican Airlines
Deal found 7/30$161
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:50 amMYR - MIA
1 stop10h 26mSpirit Airlines
Wed 8/276:50 amMIA - MYR
1 stop5h 30mSpirit Airlines
Deal found 7/29$171
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/237:15 amCAE - MIA
Nonstop1h 51mAmerican Airlines
Sat 8/307:59 pmMIA - CAE
Nonstop1h 56mAmerican Airlines
Deal found 7/29$174
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/210:40 amMYR - MIA
1 stop9h 58mFrontier
Sat 8/912:20 pmMIA - MYR
1 stop26h 35mFrontier
Deal found 7/31$187
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:35 amCHS - MIA
2 stops9h 50mSouthwest
Sat 11/156:05 amMIA - CHS
1 stop10h 45mSouthwest
Deal found 7/31$189
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2310:10 amCHS - MIA
Nonstop1h 38mAmerican Airlines
Sun 9/289:46 pmMIA - CHS
Nonstop1h 51mAmerican Airlines
Deal found 7/29$194
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/109:19 amSAV - MIA
1 stop11h 18mFrontier
Sun 10/129:42 pmMIA - SAV
1 stop10h 42mFrontier
Deal found 7/29$198

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 8/30

1:43 pm-3:48 pm

Nonstop2h 05m

Miami

Sun 9/7

6:00 am-8:11 am

Nonstop2h 11m

$110

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Thu 8/14

9:02 am-11:25 am

Nonstop2h 23m

Miami

Sun 8/17

6:00 am-8:17 am

Nonstop2h 17m

$111

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 8/16

1:43 pm-3:48 pm

Nonstop2h 05m

Miami

Thu 8/21

10:23 am-12:38 pm

Nonstop2h 15m

$116

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

Mon 8/25

10:30 am-3:20 pm

1 stop4h 50m

Miami

Thu 9/4

7:30 am-1:38 pm

1 stop6h 08m

$149

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 8/12

9:00 pm-9:22 am

1 stop12h 22m

Key West

Fri 8/15

1:47 pm-9:14 am

1 stop19h 27m

$150

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 8/30

6:50 pm-8:59 pm

Nonstop2h 09m

Miami

Tue 9/2

5:18 am-7:26 am

Nonstop2h 08m

$161

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Thu 8/21

6:50 am-5:16 pm

1 stop10h 26m

Miami

Wed 8/27

6:50 am-12:20 pm

1 stop5h 30m

$171

ColumbiaMiami

CAE - MIA

CAEMIA

Columbia Metropolitan

Sat 8/23

7:15 am-9:06 am

Nonstop1h 51m

Miami

Sat 8/30

7:59 pm-9:55 pm

Nonstop1h 56m

$174

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 8/13

1:15 pm-6:52 pm

1 stop5h 37m

Miami

Sat 8/16

12:20 pm-2:55 pm

1 stop26h 35m

$187

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Tue 11/4

10:35 am-8:25 pm

2 stops9h 50m

Miami

Sat 11/15

6:05 am-4:50 pm

1 stop10h 45m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 60 results
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6

Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EOA?

Find hourly flight availability from South Carolina to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Florida Keys as you normally would.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated July 31, 2025.
Read through reviews of airlines operating flights from South Carolina to Florida Keys, such as Southwest, Delta, and Breeze Airways. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Breeze Airways
8.0
Very good
191 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $53 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $54 and Breeze Airways from $85 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Florida Keys

Discover the top 2 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$439FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$485FlexibilityNo cancel feeOn-time71%

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