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$40+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Feb 1 — Feb 81
Sun 2/1
Sun 2/8
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:50 pmCLT - MIA
1 stop11h 00mAmerican Airlines
Thu 1/110:09 amMIA - CLT
Nonstop2h 20mAmerican Airlines
Deal found 12/31$265
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:07 pmCHS - MIA
Nonstop1h 53mAmerican Airlines
Sat 1/37:00 amMIA - CHS
Nonstop1h 47mAmerican Airlines
Deal found 12/30$309
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:07 pmCHS - MIA
Nonstop1h 53mAmerican Airlines
Sun 1/47:00 amMIA - CHS
Nonstop1h 47mAmerican Airlines
Deal found 12/31$384
This Delta deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:51 pmCLT - MIA
1 stop4h 06mDelta
Thu 1/112:45 pmMIA - CLT
1 stop6h 25mDelta
Deal found 12/31$387
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:27 pmCHS - MIA
1 stop4h 21mAmerican Airlines
Mon 1/510:56 pmMIA - CHS
Nonstop1h 49mAmerican Airlines
Deal found 12/31$394
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:00 pmGSP - EYW
1 stop6h 44mAmerican Airlines
Sun 1/48:09 pmEYW - GSP
1 stop4h 42mAmerican Airlines
Deal found 12/31$414
This American Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:08 pmMYR - MIA
1 stop10h 48mAmerican Airlines
Thu 1/19:59 amMIA - MYR
1 stop9h 13mAmerican Airlines
Deal found 12/29$415
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:15 pmCLT - MIA
Nonstop2h 08mAmerican Airlines
Mon 1/57:00 pmMIA - CLT
Nonstop2h 25mAmerican Airlines
Deal found 12/31$421
This Kiwi.com deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:04 pmCLT - EYW
1 stop11h 11mMultiple Airlines
Tue 1/612:20 pmEYW - CLT
1 stop8h 13mMultiple Airlines
Deal found 12/30$431
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmCLT - MIA
Nonstop2h 19mAmerican Airlines
Fri 1/24:53 pmMIA - CLT
1 stop4h 31mAmerican Airlines
Deal found 12/31$431
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:45 pmCLT - MIA
Nonstop2h 02mAmerican Airlines
Thu 1/16:00 amMIA - CLT
Nonstop2h 11mAmerican Airlines
Deal found 12/30$438
This Kiwi.com deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:09 pmCHS - EYW
1 stop13h 10mMultiple Airlines
Fri 1/22:30 pmEYW - CHS
1 stop6h 53mMultiple Airlines
Deal found 12/31$443

Find flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated January 2, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$85
(Flightnetwork)

One-way from

$40
(Frontier)

Popular in

April

Cheapest in

October

Average price

$342
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.
Search Deals
From South Carolina to Florida Keys
Search Deals
One-way flight from South Carolina to Florida Keys
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 2/1

9:19 pm-11:29 pm

Nonstop2h 10m

Miami

Wed 2/4

6:02 am-8:12 pm

1 stop14h 10m

$125

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

Sat 2/14

5:48 pm-7:36 pm

Nonstop1h 48m

Miami

Fri 2/20

10:19 pm-11:59 pm

Nonstop1h 40m

$140

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sat 1/31

10:00 am-11:16 pm

1 stop13h 16m

Miami

Sat 2/7

6:00 am-2:42 pm

1 stop8h 42m

$145

GreenvilleMiami

GSP - MIA

GSPMIA

Greenville

Sat 1/31

7:45 am-2:50 pm

1 stop7h 05m

Miami

Sat 2/7

7:50 am-3:35 pm

1 stop7h 45m

$148

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 2/5

8:59 pm-9:09 am

1 stop12h 10m

Key West

Mon 2/9

1:06 pm-8:38 am

1 stop19h 32m

$150

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Thu 1/29

11:40 am-9:00 pm

1 stop9h 20m

Miami

Sun 2/1

7:35 am-12:15 pm

1 stop4h 40m

$156

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Mon 1/19

7:00 pm-12:51 am

1 stop5h 51m

Miami

Thu 1/29

7:25 pm-11:55 pm

1 stop4h 30m

$157

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

Tue 2/17

8:40 am-2:13 pm

1 stop5h 33m

Miami

Wed 2/25

7:25 pm-11:57 pm

1 stop4h 32m

$159

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Sun 2/1

3:39 pm-9:35 pm

1 stop29h 56m

Miami

Sat 2/7

12:56 pm-9:04 pm

1 stop8h 08m

$165

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Wed 2/11

3:15 pm-11:59 pm

1 stop8h 44m

Miami

Mon 2/16

10:05 am-12:20 pm

Nonstop2h 15m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/31

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $64). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Florida Keys?

    Departing from South Carolina to Florida Keys will take you 1h 48m. South Carolina and Florida Keys are separated by a distance of 441 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $39 on Spirit Airlines. Other airlines that offer cheap prices include Allegiant Air from $39 and Southwest from $74 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $64). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Florida Keys

Discover the top 3 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$110Average$220FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$223Average$453FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$467FlexibilityNo cancel feeOn-time71%

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