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$44+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$90
(Cheapflightsfares)

One-way from

$44
(Frontier)

Popular in

April

Cheapest in

October

Average price

$366
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
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From South Carolina to Florida Keys
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One-way flight from South Carolina to Florida Keys
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Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:01 pmCLT - MIA
Nonstop2h 15mSpirit Airlines
Sat 12/64:56 pmMIA - CLT
Nonstop2h 14mSpirit Airlines
Deal found 11/1$90
This Frontier deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - MIA
Nonstop2h 12mFrontier
Sun 11/167:38 pmMIA - CLT
Nonstop2h 19mFrontier
Deal found 11/1$91
This Frontier deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/910:42 pmCLT - MIA
Nonstop2h 12mFrontier
Mon 11/107:38 pmMIA - CLT
Nonstop2h 19mFrontier
Deal found 11/1$92
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
Mon 11/105:45 amMIA - CLT
Nonstop2h 02mMultiple Airlines
Deal found 11/1$93
This CheapOair deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:59 amCLT - MIA
1 stop11h 50mFrontier
Mon 11/246:55 amMIA - CLT
Nonstop2h 14mFrontier
Deal found 11/2$94
This Trip.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:42 pmCLT - MIA
Nonstop2h 12mFrontier
Thu 11/209:59 pmMIA - CLT
1 stop9h 55mFrontier
Deal found 10/31$95
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:57 pmCLT - MIA
Nonstop2h 04mMultiple Airlines
Tue 12/910:25 amMIA - CLT
Nonstop2h 16mMultiple Airlines
Deal found 10/31$97
This CheapOair deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:42 pmCLT - MIA
Nonstop2h 12mFrontier
Mon 11/178:00 amMIA - CLT
1 stop12h 03mFrontier
Deal found 11/1$98
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:42 pmCLT - MIA
Nonstop2h 13mFrontier
Sun 12/710:25 amMIA - CLT
Nonstop2h 16mFrontier
Deal found 11/1$99
This Cheapflightsfares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:52 pmCLT - MIA
Nonstop2h 12mSpirit Airlines
Mon 11/246:46 amMIA - CLT
Nonstop2h 03mSpirit Airlines
Deal found 11/2$100
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/79:38 pmCLT - MIA
Nonstop2h 13mSpirit Airlines
Sun 11/95:45 amMIA - CLT
Nonstop2h 02mSpirit Airlines
Deal found 10/31$101
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:57 pmCLT - MIA
Nonstop2h 13mSpirit Airlines
Sun 11/165:45 amMIA - CLT
Nonstop2h 02mSpirit Airlines
Deal found 10/31$102

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Thu 11/20

8:59 am-8:49 pm

1 stop11h 50m

Miami

Mon 11/24

6:55 am-9:09 am

Nonstop2h 14m

$94

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 11/9

10:42 pm-12:54 am

Nonstop2h 12m

Miami

Wed 11/12

10:55 am-1:00 pm

Nonstop2h 05m

$107

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 11/8

9:57 pm-12:10 am

Nonstop2h 13m

Miami

Tue 11/11

10:55 am-1:00 pm

Nonstop2h 05m

$115

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 11/22

6:24 pm-8:35 pm

Nonstop2h 11m

Miami

Sat 11/29

3:16 pm-5:29 pm

Nonstop2h 13m

$123

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 11/8

9:57 pm-12:10 am

Nonstop2h 13m

Miami

Wed 11/12

10:55 am-1:00 pm

Nonstop2h 05m

$124

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 12/10

10:35 am-4:10 pm

1 stop5h 35m

Miami

Wed 12/17

1:30 pm-7:55 pm

1 stop6h 25m

$151

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 2/4

6:30 am-10:40 am

1 stop4h 10m

Miami

Wed 2/11

8:15 am-2:06 pm

1 stop5h 51m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Thu 12/11

5:25 am-9:27 am

1 stop4h 02m

Miami

Sat 12/13

8:05 am-1:05 pm

1 stop5h 00m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Tue 12/16

8:00 am-1:06 pm

1 stop5h 06m

Miami

Thu 12/18

7:00 am-1:23 pm

1 stop6h 23m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Sat 1/10

5:25 am-10:40 am

1 stop5h 15m

Miami

Sat 1/17

7:15 am-1:37 pm

1 stop6h 22m

$157

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/31

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, February is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $64). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EOA?

Find hourly flight availability from South Carolina to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

When flying from South Carolina to Florida Keys, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 13% versus a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Florida Keys?

    Departing from South Carolina to Florida Keys will take you 2h 13m. South Carolina and Florida Keys are separated by a distance of 652 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $44 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $49 and American Airlines from $66 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, February is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $64). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Florida Keys

Discover the top 3 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$110Average$220FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$223Average$457FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$484FlexibilityNo cancel feeOn-time71%

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