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Florida Keys

$48+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$81
(Kiwi.com)

One-way from

$48
(Kiwi.com)

Popular in

April

Cheapest in

October

Average price

$338
From South Carolina to Florida Keys
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One-way flight from South Carolina to Florida Keys
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Highest demand for flights based on searches. 6% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/310:20 pmCLT - MIA
Nonstop2h 22mFrontier
dom. 10/56:00 amMIA - CLT
Nonstop2h 11mFrontier
Deal found 9/15$81
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/127:24 pmCLT - MIA
Nonstop2h 12mFrontier
lun. 10/134:21 pmMIA - CLT
Nonstop2h 13mFrontier
Deal found 9/17$82
This CheapOair deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/137:29 pmCLT - MIA
Nonstop2h 12mFrontier
lun. 10/204:21 pmMIA - CLT
Nonstop2h 13mFrontier
Deal found 9/17$83
This Flightnetwork deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/31:50 pmCLT - MIA
Nonstop2h 15mSpirit Airlines
lun. 10/610:24 amMIA - CLT
Nonstop2h 15mSpirit Airlines
Deal found 9/16$85
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/177:24 pmCLT - MIA
Nonstop2h 12mFrontier
vie. 10/244:16 pmMIA - CLT
Nonstop2h 13mFrontier
Deal found 9/17$87
This Frontier deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/177:24 pmCLT - MIA
Nonstop2h 12mFrontier
lun. 10/204:21 pmMIA - CLT
Nonstop2h 13mFrontier
Deal found 9/17$88
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/137:29 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
jue. 10/1610:24 amMIA - CLT
Nonstop2h 15mMultiple Airlines
Deal found 9/17$89
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/131:49 pmCLT - MIA
Nonstop2h 04mSpirit Airlines
vie. 10/1710:24 amMIA - CLT
Nonstop2h 15mSpirit Airlines
Deal found 9/16$90
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/177:24 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
jue. 10/2310:24 amMIA - CLT
Nonstop2h 15mMultiple Airlines
Deal found 9/15$91
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/207:29 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
jue. 10/2310:24 amMIA - CLT
Nonstop2h 15mMultiple Airlines
Deal found 9/15$92
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/21:50 pmCLT - MIA
Nonstop2h 15mMultiple Airlines
vie. 10/103:53 pmMIA - CLT
Nonstop2h 09mMultiple Airlines
Deal found 9/15$93
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/310:20 pmCLT - MIA
Nonstop2h 22mFrontier
lun. 10/66:00 amMIA - CLT
Nonstop2h 11mFrontier
Deal found 9/16$95

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

vie. 10/17

6:00 am-7:37 am

Nonstop1h 37m

Miami

dom. 10/19

7:18 am-9:01 am

Nonstop1h 43m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

vie. 11/14

7:57 pm-9:39 pm

Nonstop1h 42m

Miami

lun. 11/17

7:00 am-8:42 am

Nonstop1h 42m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

sáb. 11/8

9:22 am-11:08 am

Nonstop1h 46m

Miami

sáb. 11/15

7:00 am-8:42 am

Nonstop1h 42m

$168

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

jue. 10/2

10:21 am-5:05 pm

1 stop6h 44m

Miami

lun. 10/6

6:15 pm-11:59 pm

1 stop5h 44m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

sáb. 10/11

6:55 pm-12:29 am

1 stop5h 34m

Miami

dom. 10/12

6:00 am-10:20 am

1 stop4h 20m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

lun. 10/27

8:03 pm-12:29 am

1 stop4h 26m

Miami

mar. 10/28

7:10 am-11:46 am

1 stop4h 36m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

mié. 10/15

5:35 am-11:04 am

1 stop5h 29m

Miami

mié. 10/22

6:00 am-10:20 am

1 stop4h 20m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

vie. 10/3

5:10 am-9:20 am

1 stop4h 10m

Miami

lun. 10/6

6:15 pm-11:59 pm

1 stop5h 44m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

mié. 10/1

6:20 am-11:01 am

1 stop4h 41m

Miami

mié. 10/22

6:00 am-10:20 am

1 stop4h 20m

$177

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

sáb. 10/25

6:55 pm-12:29 am

1 stop5h 34m

Miami

lun. 10/27

6:00 am-10:20 am

1 stop4h 20m

$177

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EOA?

Find hourly flight availability from South Carolina to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Florida Keys as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Florida Keys?

    Departing from South Carolina to Florida Keys will take you 1h 37m. South Carolina and Florida Keys are separated by a distance of 490 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $49 on Spirit Airlines. Other airlines that offer cheap prices include American Airlines from $79 and Southwest from $84 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Florida Keys

Discover the top 2 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$223Average$460FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$495FlexibilityNo cancel feeOn-time71%

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