$40+ Cheap flights from South Carolina to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
May 10 — May 171
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Florida Keys with Cheapflights
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Cheapest flights from South Carolina to Florida KeysExplore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Mon 4/279:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/10![Spirit Airlines logo]()
$83
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:28 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Fri 4/2411:17 am
MIA
- CLT
Nonstop2h 26m
Frontier
Deal found 4/6![Frontier logo]()
$84
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- MIA
Nonstop1h 59m
Multiple Airlines
Thu 5/72:59 pm
MIA
- CLT
Nonstop2h 14m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$85
This Cheapflightsfares deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
CLT
- MIA
Nonstop2h 02m
Spirit Airlines
Fri 4/179:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/8![Spirit Airlines logo]()
$86
This Mytrip deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
CLT
- MIA
Nonstop2h 02m
Spirit Airlines
Thu 4/169:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/5![Spirit Airlines logo]()
$87
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
CLT
- MIA
Nonstop2h 18m
Frontier
Fri 4/1711:17 am
MIA
- CLT
Nonstop2h 26m
Frontier
Deal found 4/8![Frontier logo]()
$88
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Thu 4/308:12 am
MIA
- CLT
1 stop8h 56m
Spirit Airlines
Deal found 4/10![Spirit Airlines logo]()
$89
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:33 pm
CLT
- MIA
Nonstop2h 13m
Frontier
Sat 5/232:59 pm
MIA
- CLT
Nonstop2h 14m
Frontier
Deal found 4/8![Frontier logo]()
$90
This Cheapflightsfares deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Fri 4/249:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/9![Spirit Airlines logo]()
$91
This Priceline deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Fri 4/248:12 am
MIA
- CLT
1 stop8h 56m
Spirit Airlines
Deal found 4/6![Spirit Airlines logo]()
$92
This Frontier deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:15 am
CLT
- MIA
Nonstop2h 18m
Frontier
Fri 4/1010:00 pm
MIA
- CLT
Nonstop2h 25m
Frontier
Deal found 4/7![Frontier logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:00 am
CLT
- MIA
Nonstop2h 02m
Multiple Airlines
Sat 4/1110:28 pm
MIA
- CLT
Nonstop2h 25m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$94
Best flights from South Carolina to Florida KeysDiscover carefully curated flight deals from South Carolina to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
Discover carefully curated flight deals from South Carolina to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
This Breeze Airways deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:20 pm
CHS
- EYW
1 stop16h 11m
Breeze Airways
Fri 8/2812:07 pm
EYW
- CHS
1 stop20h 41m
Breeze Airways
Deal found 4/9![Breeze Airways logo]()
$179
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1610:55 am
CHS
- MIA
2 stops8h 45m
Southwest
Sat 5/2311:50 am
MIA
- CHS
1 stop7h 20m
Southwest
Deal found 4/5![Southwest logo]()
$232
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/204:15 pm
AGS
- MIA
1 stop6h 36m
American Airlines
Wed 6/36:20 am
MIA
- AGS
1 stop5h 58m
American Airlines
Deal found 4/8![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:43 pm
MYR
- EYW
1 stop5h 57m
Delta
Wed 5/137:30 am
EYW
- MYR
1 stop5h 10m
Delta
Deal found 4/6![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:34 am
CAE
- MIA
1 stop5h 42m
United Airlines
Sat 5/96:10 pm
MIA
- CAE
1 stop5h 49m
United Airlines
Deal found 4/10![United Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:39 pm
MYR
- MIA
1 stop15h 25m
Spirit Airlines
Sun 5/1010:57 am
MIA
- MYR
1 stop22h 17m
Spirit Airlines
Deal found 4/10![Spirit Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/194:04 pm
MYR
- EYW
1 stop19h 03m
Multiple Airlines
Thu 7/237:56 pm
EYW
- MYR
2 stops13h 54m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$340
This Breeze Airways deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/139:44 pm
CHS
- EYW
1 stop14h 50m
Breeze Airways
Wed 7/1511:46 am
EYW
- CHS
1 stop3h 42m
Breeze Airways
Deal found 4/6![Breeze Airways logo]()
$199
This Breeze Airways deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:56 pm
CHS
- EYW
1 stop22h 20m
Breeze Airways
Mon 7/2712:07 pm
EYW
- CHS
1 stop20h 31m
Breeze Airways
Deal found 4/10![Breeze Airways logo]()
$216
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:25 pm
CHS
- MIA
1 stop6h 45m
Southwest
Thu 5/281:45 pm
MIA
- CHS
2 stops7h 45m
Southwest
Deal found 4/5![Southwest logo]()
$263
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:14 am
MYR
- EYW
2 stops8h 16m
American Airlines
Wed 5/134:20 pm
EYW
- MYR
1 stop6h 04m
American Airlines
Deal found 4/6![American Airlines logo]()
$296
This Breeze Airways deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:49 pm
CHS
- EYW
1 stop10h 20m
Breeze Airways
Sun 5/39:46 am
EYW
- CHS
1 stop6h 39m
Breeze Airways
Deal found 4/6![Breeze Airways logo]()
$252
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/44:01 pm
CAE
- MIA
1 stop4h 47m
Delta
Sun 5/106:00 am
MIA
- CAE
1 stop5h 11m
Delta
Deal found 4/10![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:45 pm
CHS
- MIA
1 stop6h 15m
Southwest
Sat 6/66:20 am
MIA
- CHS
2 stops9h 05m
Southwest
Deal found 4/6![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:03 pm
CHS
- MIA
1 stop6h 45m
Delta
Mon 6/17:39 pm
MIA
- CHS
1 stop4h 20m
Delta
Deal found 4/6![Delta logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:47 pm
MYR
- EYW
2 stops17h 11m
Multiple Airlines
Wed 6/311:46 am
EYW
- MYR
1 stop24h 33m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:34 pm
AGS
- MIA
1 stop4h 22m
American Airlines
Sun 5/247:40 am
MIA
- AGS
1 stop6h 37m
American Airlines
Deal found 4/8![American Airlines logo]()
$332
This Breeze Airways deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:53 pm
CHS
- EYW
1 stop20h 34m
Breeze Airways
Thu 6/412:05 pm
EYW
- CHS
1 stop20h 40m
Breeze Airways
Deal found 4/10![Breeze Airways logo]()
$283
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:00 am
CHS
- MIA
1 stop5h 36m
United Airlines
Tue 5/1912:50 pm
MIA
- CHS
1 stop9h 09m
United Airlines
Deal found 4/6![United Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:43 pm
AGS
- MIA
1 stop7h 00m
Delta
Sun 5/246:00 am
MIA
- AGS
1 stop5h 10m
Delta
Deal found 4/9![Delta logo]()
$332
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:54 pm
AGS
- MIA
1 stop5h 48m
American Airlines
Mon 5/187:45 am
MIA
- AGS
1 stop4h 42m
American Airlines
Deal found 4/9![American Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1212:00 pm
CHS
- MIA
2 stops9h 55m
Southwest
Thu 5/146:20 am
MIA
- CHS
2 stops12h 00m
Southwest
Deal found 4/5![Southwest logo]()
$339
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:45 pm
AGS
- MIA
1 stop5h 03m
Delta
Sun 10/46:00 am
MIA
- AGS
1 stop4h 57m
Delta
Deal found 4/9![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/224:10 pm
CHS
- MIA
1 stop7h 05m
Southwest
Thu 6/253:05 pm
MIA
- CHS
1 stop6h 50m
Southwest
Deal found 4/6![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
MYR
- EYW
1 stop4h 46m
Delta
Sat 4/256:18 pm
EYW
- MYR
1 stop5h 56m
Delta
Deal found 4/6![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:15 pm
AGS
- MIA
1 stop6h 36m
American Airlines
Sat 5/26:54 am
MIA
- AGS
1 stop5h 33m
American Airlines
Deal found 4/7![American Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:45 pm
CHS
- MIA
1 stop6h 15m
Southwest
Sun 5/176:45 am
MIA
- CHS
1 stop9h 15m
Southwest
Deal found 4/10![Southwest logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/73:53 pm
MYR
- EYW
1 stop19h 34m
Breeze Airways
Thu 6/1112:05 pm
EYW
- MYR
1 stop21h 00m
Breeze Airways
Deal found 4/5![Breeze Airways logo]()
$354
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:38 pm
CAE
- MIA
2 stops26h 55m
United Airlines
Sat 5/166:10 pm
MIA
- CAE
1 stop5h 49m
United Airlines
Deal found 4/9![United Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:15 pm
AGS
- MIA
1 stop6h 36m
American Airlines
Thu 5/145:30 pm
MIA
- AGS
1 stop6h 28m
American Airlines
Deal found 4/7![American Airlines logo]()
$383
Last-minute flights from South Carolina to Florida KeysDiscover last-minute flight deals from South Carolina to Florida Keys. Data last updated April 10, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Florida Keys. Data last updated April 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:00 am
CLT
- MIA
Nonstop2h 02m
Multiple Airlines
Sat 4/1110:28 pm
MIA
- CLT
Nonstop2h 25m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$94
This Priceline deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:00 am
CLT
- MIA
Nonstop2h 02m
Spirit Airlines
Fri 4/179:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/7![Spirit Airlines logo]()
$93
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
CLT
- MIA
Nonstop2h 18m
Frontier
Fri 4/1711:17 am
MIA
- CLT
Nonstop2h 26m
Frontier
Deal found 4/8![Frontier logo]()
$88
This Cheapflightsfares deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
CLT
- MIA
Nonstop2h 02m
Spirit Airlines
Fri 4/179:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/8![Spirit Airlines logo]()
$86
This Flightnetwork deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
CLT
- MIA
Nonstop2h 02m
Spirit Airlines
Thu 4/169:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/5![Spirit Airlines logo]()
$87
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:28 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Fri 4/2411:17 am
MIA
- CLT
Nonstop2h 26m
Frontier
Deal found 4/6![Frontier logo]()
$84
This Cheapflightsfares deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Fri 4/249:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/9![Spirit Airlines logo]()
$91
This Cheapflightsfares deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Mon 4/279:34 am
MIA
- CLT
Nonstop2h 11m
Spirit Airlines
Deal found 4/10![Spirit Airlines logo]()
$83
This Priceline deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Fri 4/248:12 am
MIA
- CLT
1 stop8h 56m
Spirit Airlines
Deal found 4/6![Spirit Airlines logo]()
$92
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Thu 4/308:12 am
MIA
- CLT
1 stop8h 56m
Spirit Airlines
Deal found 4/10![Spirit Airlines logo]()
$89
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- MIA
Nonstop1h 59m
Multiple Airlines
Thu 5/72:59 pm
MIA
- CLT
Nonstop2h 14m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$85
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:33 pm
CLT
- MIA
Nonstop2h 13m
Frontier
Sat 5/232:59 pm
MIA
- CLT
Nonstop2h 14m
Frontier
Deal found 4/8![Frontier logo]()
$90
One-way flights from South Carolina to Florida KeysSearch for one-way flight options from South Carolina to Florida Keys. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
Search for one-way flight options from South Carolina to Florida Keys. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:33 pm
CLT
- MIA
Nonstop2h 13m
Frontier
Deal found 4/6![Frontier logo]()
$40
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:23 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Deal found 4/6![Frontier logo]()
$41
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Deal found 4/6![Spirit Airlines logo]()
$43
This CheapOair deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- MIA
Nonstop1h 59m
Spirit Airlines
Deal found 4/5![Spirit Airlines logo]()
$44
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/712:48 pm
CLT
- MIA
Nonstop2h 06m
Spirit Airlines
Deal found 4/6![Spirit Airlines logo]()
$45
This iWofly deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure iWofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:45 pm
CLT
- MIA
Nonstop2h 13m
Frontier
Deal found 4/6![Frontier logo]()
$48
This iWofly deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure iWofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:33 pm
CLT
- MIA
Nonstop2h 23m
Frontier
Deal found 4/8![Frontier logo]()
$49
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:56 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Deal found 4/8![Frontier logo]()
$50
This Frontier deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:56 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Deal found 4/7![Frontier logo]()
$51
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:56 pm
CLT
- MIA
Nonstop2h 17m
Frontier
Deal found 4/6![Frontier logo]()
$55
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:15 pm
MYR
- MIA
1 stop27h 19m
Frontier
Deal found 4/8![Frontier logo]()
$83
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:50 am
CLT
- EYW
1 stop7h 58m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$83
Find flight deals from South Carolina to Florida Keys
Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated April 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $83 (Trip.com) |
One-way from | $40 (Frontier) |
Popular in | February |
Cheapest in | August |
Average price | $380 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKey West
CHS - EYW
CHSEYW
Charleston
Sun 8/23
8:20 pm-12:31 pm
1 stop16h 11m
Key West
Fri 8/28
12:07 pm-8:48 am
1 stop20h 41m
$179
CharlestonKey West
CHS - EYW
CHSEYW
Charleston
Mon 7/13
9:44 pm-12:34 pm
1 stop14h 50m
Key West
Wed 7/15
11:46 am-3:28 pm
1 stop3h 42m
$199
CharlestonKey West
CHS - EYW
CHSEYW
Charleston
Wed 7/22
8:56 pm-7:16 pm
1 stop22h 20m
Key West
Mon 7/27
12:07 pm-8:38 am
1 stop20h 31m
$216
CharlestonMiami
CHS - MIA
CHSMIA
Charleston
Sat 5/16
10:55 am-7:40 pm
2 stops8h 45m
Miami
Sat 5/23
11:50 am-7:10 pm
1 stop7h 20m
$232
CharlestonKey West
CHS - EYW
CHSEYW
Charleston
Thu 4/30
10:49 pm-9:09 am
1 stop10h 20m
Key West
Sun 5/3
9:46 am-4:25 pm
1 stop6h 39m
$252
CharlestonMiami
CHS - MIA
CHSMIA
Charleston
Wed 5/27
2:25 pm-9:10 pm
1 stop6h 45m
Miami
Thu 5/28
1:45 pm-9:30 pm
2 stops7h 45m
$263
AugustaMiami
AGS - MIA
AGSMIA
Augusta Bush Field
Wed 5/20
4:15 pm-10:51 pm
1 stop6h 36m
Miami
Wed 6/3
6:20 am-12:18 pm
1 stop5h 58m
$281
CharlestonKey West
CHS - EYW
CHSEYW
Charleston
Sun 5/31
2:53 pm-11:27 am
1 stop20h 34m
Key West
Thu 6/4
12:05 pm-8:45 am
1 stop20h 40m
$283
Myrtle BeachKey West
MYR - EYW
MYREYW
Myrtle Beach Intl
Tue 5/5
1:43 pm-7:40 pm
1 stop5h 57m
Key West
Wed 5/13
7:30 am-12:40 pm
1 stop5h 10m
$291
Myrtle BeachKey West
MYR - EYW
MYREYW
Myrtle Beach Intl
Tue 5/5
8:14 am-4:30 pm
2 stops8h 16m
Key West
Wed 5/13
4:20 pm-10:24 pm
1 stop6h 04m
$296
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
CLT-MIA
CHS-MIA
CHS-EYW
CAE-MIA
MYR-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Florida Keys
USSC-zzEOA
CLT-MIA
CHS-MIA
CHS-EYW
CAE-MIA
What is the cheapest month to book a flight from South Carolina to Florida Keys?
Currently, June is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $91). Flying from South Carolina to Florida Keys in April is currently the most expensive (average of $307). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Top destinations
Alternative routes for South Carolina to Florida Keys
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Florida Keys by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Florida Keys by cabin class
Find flights from South Carolina to Florida Keys, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Florida Keys flights
Browse other South Carolina and Florida Keys flight options. Last updated on April 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Florida Keys
Find the right flight back to South Carolina after your stay in Florida Keys
South Carolina to Florida Keys flights
Consider these flights traveling from South Carolina to Florida Keys.
Top 3 airlines flying from South Carolina to Florida Keys
Discover the top 3 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$110 | Average$220 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$125 | Average$452 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$468 | FlexibilityNo cancel fee | On-time71% |