What is the cheapest airline to fly from San Francisco to Florence, South Carolina round-trip?

Flying on American Airlines is currently your cheapest option to Florence, South Carolina, with prices starting at $400.

What is the cheapest day to fly from San Francisco to Florence, South Carolina?

Travelers seeking maximum savings on their San Francisco to Florence, South Carolina flight should consider departing on Friday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Florence, South Carolina ranges from 2.5 - 5.4 inches per month. July is typically the wettest month, when rainfall can reach 5.4 in. November is typically the driest time to visit Florence, South Carolina when rainfall is around 2.5 in.

If weather is an important factor for your trip to Florence, South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

What is the cheapest day to fly round-trip from San Francisco to Florence, South Carolina?

Flying to your destination on a Friday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Florence, South Carolina. Check prices with Cheapflights to find a great deal for your trip.

What is the cheapest time of day to fly from SFO to FLO?

It’s optimal to fly from San Francisco to Florence, South Carolina in the morning. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight at noon.

Can I find deals for flights from San Francisco to Florence that include hotel bookings?

Yes. In addition to deals on San Francisco to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Florence?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Florence.

Can I find deals for business class flights from San Francisco to Florence?

Yes. Cheapflights offers flight deals from San Francisco to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$189+ Flights from San Francisco to Florence, SC

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One-way flights from San Francisco to Florence
Search for one-way flight options from San Francisco to Florence. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Tue 12/211:59 pmSFO - FLO

1 stop6h 51mAmerican Airlines

Deal found 9/10

$189

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 12/2

11:59 pm-9:50 am

1 stop6h 51m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from San Francisco to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Florence

What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $366). Flying from San Francisco to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get a feel of what it's like to fly with American Airlines from San Francisco to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

2.0

Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

What is the cheapest airline to fly from San Francisco to Florence, South Carolina round-trip?
Flying on American Airlines is currently your cheapest option to Florence, South Carolina, with prices starting at $400.
Can I find deals for flights from San Francisco to Florence that include hotel bookings?
Yes. In addition to deals on San Francisco to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Florence?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Florence.
Can I find deals for business class flights from San Francisco to Florence?
Yes. Cheapflights offers flight deals from San Francisco to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $366). Flying from San Francisco to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Sumter

Hartsville

Darlington

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Top airline flying from San Francisco to Florence

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$400	Average$512	FlexibilityNo cancel fee	On-time71%

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$189+ Cheap flights from San Francisco to Florence, SC (SFO - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Florence with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from San Francisco to Florence

One-way flights from San Francisco to FlorenceSearch for one-way flight options from San Francisco to Florence. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Search for one-way flight options from San Francisco to Florence. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Florence that are best for you.

Best time to book a flight from San Francisco to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Florence

What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

Reviews of airlines servicing Florence

Get a feel of what it's like to fly with American Airlines from San Francisco to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from San Francisco to Florence, South Carolina round-trip?

Can I find deals for flights from San Francisco to Florence that include hotel bookings?

How can I find direct flights from San Francisco to Florence?

Can I find deals for business class flights from San Francisco to Florence?

What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

Traveling to a place near Florence?

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Alternative routes for San Francisco to Florence

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Top airline flying from San Francisco to Florence

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One-way flights from San Francisco to Florence
Search for one-way flight options from San Francisco to Florence. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.