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$401+ Cheap flights from Orlando (ORL) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
ORL — FLO
Jun 7 — Jun 141
Sun 6/7
Sun 6/14
1 adult, Economy
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Cheap flight deals from Orlando to Florence

Cheapest flights from Orlando to Florence
Explore the most affordable flight options available from Orlando to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 8, 2026.

This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:45 am
MCO
-
FLO
1 stop5h 24m
American Airlines
Tue 10/272:17 pm
FLO
-
MCO
1 stop3h 42m
American Airlines
Deal found 5/6$447
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:00 am
MCO
-
FLO
1 stop6h 10m
American Airlines
Wed 5/272:35 pm
FLO
-
MCO
1 stop5h 25m
American Airlines
Deal found 5/7$507
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:05 pm
MCO
-
FLO
2 stops7h 42m
American Airlines
Tue 5/124:02 pm
FLO
-
MCO
1 stop5h 14m
American Airlines
Deal found 5/7$1,448

Find flight deals from Orlando to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Orlando (ORL) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$447
(American Airlines)

One-way from

$401
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
Search Deals
From Orlando (ORL) to Florence
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One-way flight from Orlando (ORL) to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Orlando to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Orlando to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 10/21

8:45 am-2:09 pm

1 stop5h 24m

Florence

Tue 10/27

2:17 pm-5:59 pm

1 stop3h 42m

$447

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 5/23

8:00 am-2:10 pm

1 stop6h 10m

Florence

Wed 5/27

2:35 pm-8:00 pm

1 stop5h 25m

$507
Cheapest one-way

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 5/19

3:49 pm-10:42 pm

1 stop6h 53m

$401

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 5/22

3:32 pm-10:00 pm

1 stop6h 28m

$426

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sun 6/7

9:00 am-2:10 pm

1 stop5h 10m

$427

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sun 5/17

11:39 am-3:50 pm

1 stop4h 11m

$427

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Mon 5/18

7:00 am-3:50 pm

2 stops8h 50m

$431

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 5/21

10:58 am-10:00 pm

2 stops11h 02m

$461
Quickest one-way

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 10/9

10:43 am-2:09 pm

1 stop3h 26m

$477

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/7

Sorted by cheapest first

Compare providers for flights from Orlando to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Orlando to Florence in May.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Orlando-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Orlando-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Orlando-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Orlando-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Orlando-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Orlando to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Orlando with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Orlando to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Orlando to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Orlando?

    If you book a flight to Florence from Orlando, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence. There are 0 flights from Orlando to Florence per day from 0 different airlines.

  • How long is the flight from Orlando to Florence, South Carolina?

    Airlines like American Airlines fly from Orlando to Florence, South Carolina in about 5h 24m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 408 mi.

  • Can I find deals for flights from Orlando to Florence that include hotel bookings?

    Yes. In addition to deals on Orlando to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Orlando to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Orlando to Florence.

  • Can I find deals for business class flights from Orlando to Florence?

    Yes. Cheapflights offers flight deals from Orlando to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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