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$413+ Cheap flights from Milwaukee to Florence, SC (MKE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — FLO
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Milwaukee to Florence

Cheapest flights from Milwaukee to Florence
Explore the most affordable flight options available from Milwaukee to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:37 pm
MKE
-
FLO
1 stop4h 20m
American Airlines
Fri 4/105:20 am
FLO
-
MKE
1 stop7h 10m
American Airlines
Deal found 3/22$413

Find flight deals from Milwaukee to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Milwaukee (MKE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$413
(American Airlines)
Provider with most accurate pricing for Milwaukee-Mitchell-Florence flight deals.
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Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Florence flights.
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From Milwaukee-Mitchell to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Milwaukee to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Mon 4/6

6:37 pm-11:57 pm

1 stop4h 20m

Florence

Fri 4/10

5:20 am-1:23 pm

2 stops9h 03m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/22

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Milwaukee-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Milwaukee-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Milwaukee-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Milwaukee-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Milwaukee-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Milwaukee to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to Florence

What is the cheapest month to book a flight from Milwaukee to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Milwaukee to Florence, South Carolina (average of $56). Flying from Milwaukee to Florence, South Carolina in March is currently the most expensive (average of $108). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Milwaukee to Florence, South Carolina?

    A quick flight from Milwaukee to Florence, South Carolina can take about 4h 20m. American Airlines provides one of the quickest options available for as low as $418. The distance from Milwaukee to Florence, South Carolina is about 748 mi.

  • Can I find deals for flights from Milwaukee to Florence that include hotel bookings?

    Yes. In addition to deals on Milwaukee to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to Florence.

  • Can I find deals for business class flights from Milwaukee to Florence?

    Yes. Cheapflights offers flight deals from Milwaukee to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Milwaukee to Florence, South Carolina (average of $56). Flying from Milwaukee to Florence, South Carolina in March is currently the most expensive (average of $108). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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