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$320+ Cheap flights from Milwaukee to Florence, SC (MKE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Milwaukee to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Milwaukee (MKE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$320
(American Airlines)
From Milwaukee-Mitchell to Florence
Search Deals

Find flight deals from Milwaukee to Florence

Cheapest flights from Milwaukee to Florence
Explore the most affordable flight options available from Milwaukee to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:47 pmMKE - FLO
1 stop6h 29mAmerican Airlines
Tue 9/305:37 pmFLO - MKE
1 stop6h 23mAmerican Airlines
Deal found 9/11$320
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:20 pmMKE - FLO
1 stop4h 53mAmerican Airlines
Mon 9/2912:27 pmFLO - MKE
1 stop3h 48mAmerican Airlines
Deal found 9/9$437

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Milwaukee to Florence that are best for you.

Fly from

Milwaukee

Fly to

Florence

Route

Depart

Return

Price

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Fri 9/26

3:47 pm-11:16 pm

1 stop6h 29m

Florence

Tue 9/30

5:37 pm-11:00 pm

1 stop6h 23m

$320

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Thu 9/25

6:20 pm-12:13 am

1 stop4h 53m

Florence

Mon 9/29

12:27 pm-3:15 pm

1 stop3h 48m

$437

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Thu 9/25

6:20 pm-12:13 am

1 stop4h 53m

Florence

Sun 9/28

5:14 am-1:57 pm

2 stops9h 43m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Milwaukee to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to Florence

What is the cheapest month to book a flight from Milwaukee to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Milwaukee to Florence, South Carolina (average of $366). Flying from Milwaukee to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Milwaukee to Florence, South Carolina?

    A quick flight from Milwaukee to Florence, South Carolina can take about 6h 29m. American Airlines provides one of the quickest options available for as low as $320. The distance from Milwaukee to Florence, South Carolina is about 748 mi.

  • Can I find deals for flights from Milwaukee to Florence that include hotel bookings?

    Yes. In addition to deals on Milwaukee to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to Florence.

  • Can I find deals for business class flights from Milwaukee to Florence?

    Yes. Cheapflights offers flight deals from Milwaukee to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Milwaukee to Florence, South Carolina (average of $366). Flying from Milwaukee to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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