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$279+ Cheap flights from Maine to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Maine to Florence

Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
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Provider most trusted by Cheapflights users for Portland-Florence flights.
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From Maine to Florence
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Find flight deals from Maine to Florence

Cheapest flights from Maine to Florence
Explore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:25 amBOS - FLO
1 stop5h 20mAmerican Airlines
Thu 1/86:15 amFLO - BOS
1 stop6h 43mAmerican Airlines
Deal found 10/29$299
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:52 amBOS - FLO
1 stop4h 59mAmerican Airlines
Sat 12/136:31 pmFLO - BOS
1 stop4h 13mAmerican Airlines
Deal found 10/28$329
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:52 amBOS - FLO
1 stop4h 59mAmerican Airlines
Mon 12/155:35 pmFLO - BOS
1 stop6h 40mAmerican Airlines
Deal found 10/28$349
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/610:47 amBOS - FLO
2 stops7h 18mAmerican Airlines
Fri 12/1210:28 amFLO - BOS
1 stop3h 58mAmerican Airlines
Deal found 10/28$354
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:13 pmBOS - FLO
1 stop6h 40mAmerican Airlines
Sun 12/1411:16 amFLO - BOS
1 stop5h 39mAmerican Airlines
Deal found 10/28$369
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:25 amBOS - FLO
1 stop5h 26mAmerican Airlines
Sun 12/145:15 amFLO - BOS
2 stops7h 50mAmerican Airlines
Deal found 10/28$374
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:53 amBOS - FLO
1 stop6h 33mAmerican Airlines
Sun 5/3111:16 amFLO - BOS
1 stop3h 53mAmerican Airlines
Deal found 10/28$389

Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Maine to Florence that are best for you.

Fly from

Maine

Fly to

Florence

Route

Depart

Return

Price

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Mon 1/19

11:21 am-5:09 pm

1 stop5h 48m

Florence

Sat 5/9

2:33 pm-8:09 pm

1 stop5h 36m

$279

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 1/24

6:23 pm-11:11 pm

1 stop4h 48m

Florence

Sat 5/16

2:33 pm-6:26 pm

1 stop3h 53m

$279

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 12/6

5:52 am-10:51 am

1 stop4h 59m

Florence

Sat 12/13

6:31 pm-10:44 pm

1 stop4h 13m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 12/10

6:19 pm-10:53 pm

1 stop4h 34m

Florence

Tue 12/16

11:15 am-3:53 pm

1 stop4h 38m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 12/9

6:19 pm-10:53 pm

1 stop4h 34m

Florence

Tue 12/16

11:15 am-3:53 pm

1 stop4h 38m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 12/6

12:00 pm-6:05 pm

1 stop6h 05m

Florence

Wed 12/10

6:15 am-12:34 pm

1 stop6h 19m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 12/6

1:45 pm-6:05 pm

1 stop4h 20m

Florence

Tue 12/16

6:15 am-12:34 pm

1 stop6h 19m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 12/10

6:19 pm-10:53 pm

1 stop4h 34m

Florence

Sat 12/13

11:16 am-10:16 pm

2 stops11h 00m

$334

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 12/9

2:08 pm-10:53 pm

2 stops8h 45m

Florence

Sat 12/13

11:16 am-10:16 pm

2 stops11h 00m

$339

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 3/25

7:50 am-2:05 pm

1 stop6h 15m

Florence

Sat 3/28

2:30 pm-10:32 pm

2 stops8h 02m

$536

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Best time to book a flight from Maine to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Florence

What is the cheapest month to book a flight from Maine to Florence, South Carolina?

Currently, March is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $88). Flying from Maine to Florence, South Carolina in December is currently the most expensive (average of $156). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Maine to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Maine?

    Most people fly into Florence (FLO) if they book a flight to Florence from Maine. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Maine to Florence, South Carolina in about 5h 48m. The time it takes to get you to your destination can typically vary by up to . The distance from Maine to Florence, South Carolina is about 735 mi.

  • Can I find deals for flights from Maine to Florence that include hotel bookings?

    Yes. In addition to deals on Maine to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Florence.

  • Can I find deals for business class flights from Maine to Florence?

    Yes. Cheapflights offers flight deals from Maine to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Maine to Florence, South Carolina?

    Currently, March is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $88). Flying from Maine to Florence, South Carolina in December is currently the most expensive (average of $156). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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