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$284+ Cheap flights from Maine to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Jan 31 — Feb 71
Sat 1/31
Sat 2/7
1 adult, Economy
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Cheap flight deals from Maine to Florence

Best flights from Maine to Florence
Discover carefully curated flight deals from Maine to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 1, 2026.

This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:05 amBOS - FLO
2 stops9h 45mAmerican Airlines
Tue 3/106:15 amFLO - BOS
1 stop4h 42mAmerican Airlines
Deal found 12/30$284
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/275:20 pmBOS - FLO
1 stop5h 23mAmerican Airlines
Tue 2/35:36 pmFLO - BOS
1 stop6h 15mAmerican Airlines
Deal found 12/30$299
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2812:21 pmBOS - FLO
1 stop4h 48mAmerican Airlines
Wed 2/46:15 amFLO - BOS
1 stop6h 43mAmerican Airlines
Deal found 12/31$299
This American Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/136:23 pmBOS - FLO
1 stop4h 20mAmerican Airlines
Sat 1/175:36 pmFLO - BOS
1 stop4h 46mAmerican Airlines
Deal found 12/28$339
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:52 pmBOS - FLO
1 stop5h 05mAmerican Airlines
Fri 2/205:16 amFLO - BOS
2 stops9h 28mAmerican Airlines
Deal found 12/31$374
This American Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/155:20 amPWM - FLO
2 stops11h 49mAmerican Airlines
Mon 1/196:15 amFLO - PWM
2 stops10h 22mAmerican Airlines
Deal found 12/31$438
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:48 amPWM - FLO
2 stops13h 05mAmerican Airlines
Wed 4/225:24 amFLO - PWM
2 stops18h 30mAmerican Airlines
Deal found 12/30$819

Find flight deals from Maine to Florence

Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated January 1, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
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Provider most trusted by Cheapflights users for Portland-Florence flights.
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From Maine to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 1, 2026.
Use the filters below to find and compare flights from Maine to Florence that are best for you.

Fly from

Maine

Fly to

Florence

Route

Depart

Return

Price

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sun 3/1

8:05 am-5:50 pm

2 stops9h 45m

Florence

Tue 3/10

6:15 am-10:57 am

1 stop4h 42m

$284

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 1/27

5:20 pm-10:43 pm

1 stop5h 23m

Florence

Tue 2/3

5:36 pm-11:51 pm

1 stop6h 15m

$299

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 1/28

12:21 pm-5:09 pm

1 stop4h 48m

Florence

Wed 2/4

6:15 am-12:58 pm

1 stop6h 43m

$299

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 1/13

6:23 pm-10:43 pm

1 stop4h 20m

Florence

Sat 1/17

5:36 pm-10:22 pm

1 stop4h 46m

$339

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Fri 2/13

6:52 pm-11:57 pm

1 stop5h 05m

Florence

Fri 2/20

5:16 am-2:44 pm

2 stops9h 28m

$374

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 1/15

5:20 am-5:09 pm

2 stops11h 49m

Florence

Mon 1/19

6:15 am-4:37 pm

2 stops10h 22m

$438

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Fri 4/17

10:48 am-11:53 pm

2 stops13h 05m

Florence

Wed 4/22

5:24 am-11:54 pm

2 stops18h 30m

$819

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 1/13

9:51 am-10:43 pm

2 stops12h 52m

$368

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Mon 1/12

5:59 pm-10:43 pm

2 stops28h 44m

$368

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/30

Best time to book a flight from Maine to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Florence

What is the cheapest month to book a flight from Maine to Florence, South Carolina?

Currently, March is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $88). Flying from Maine to Florence, South Carolina in December is currently the most expensive (average of $158). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Maine to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Maine?

    Most people fly into Florence (FLO) if they book a flight to Florence from Maine. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Maine to Florence, South Carolina in about 9h 45m. The time it takes to get you to your destination can typically vary by up to . The distance from Maine to Florence, South Carolina is about 735 mi.

  • Can I find deals for flights from Maine to Florence that include hotel bookings?

    Yes. In addition to deals on Maine to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Florence.

  • Can I find deals for business class flights from Maine to Florence?

    Yes. Cheapflights offers flight deals from Maine to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Maine to Florence, South Carolina?

    Currently, March is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $88). Flying from Maine to Florence, South Carolina in December is currently the most expensive (average of $158). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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