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Florence

$324+ Cheap flights from Maine to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Maine to Florence

Cheapest flights from Maine to Florence
Explore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:40 pm
BOS
-
FLO
1 stop6h 12m
American Airlines
Sat 5/164:16 pm
FLO
-
BOS
1 stop5h 38m
American Airlines
Deal found 2/27$369
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/198:07 am
BOS
-
FLO
2 stops7h 25m
American Airlines
Wed 5/275:09 am
FLO
-
BOS
2 stops6h 53m
American Airlines
Deal found 2/24$379
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:55 pm
BOS
-
FLO
1 stop5h 02m
American Airlines
Sat 6/132:35 pm
FLO
-
BOS
1 stop5h 33m
American Airlines
Deal found 2/26$383
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:15 am
BOS
-
FLO
1 stop6h 56m
American Airlines
Fri 7/242:36 pm
FLO
-
BOS
1 stop6h 16m
American Airlines
Deal found 2/25$386
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:57 am
BOS
-
FLO
1 stop4h 24m
American Airlines
Sun 10/411:20 am
FLO
-
BOS
1 stop3h 55m
American Airlines
Deal found 2/25$389
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:57 am
BOS
-
FLO
1 stop4h 24m
American Airlines
Sun 10/411:20 am
FLO
-
BOS
1 stop3h 55m
American Airlines
Deal found 2/25$409
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/510:56 am
BOS
-
FLO
1 stop6h 54m
American Airlines
Mon 3/96:20 pm
FLO
-
BOS
1 stop4h 31m
American Airlines
Deal found 2/25$419
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:29 am
PWM
-
FLO
2 stops18h 28m
American Airlines
Wed 3/185:16 am
FLO
-
PWM
2 stops18h 39m
American Airlines
Deal found 2/27$528
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:58 am
PWM
-
FLO
2 stops6h 52m
American Airlines
Mon 3/166:20 pm
FLO
-
PWM
1 stop4h 30m
American Airlines
Deal found 2/25$664

Find flight deals from Maine to Florence

Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated February 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

Popular in

July

Cheapest in

March

Average price

$372
Provider with most accurate pricing for Boston Logan Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Boston Logan Intl-Florence flights.
Search Deals
From Maine to Florence
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Maine to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 3/24

4:10 pm-11:08 pm

1 stop6h 58m

Florence

Tue 3/31

6:15 am-2:44 pm

2 stops8h 29m

$324

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 5/19

5:40 pm-10:42 pm

1 stop5h 02m

Florence

Wed 5/27

2:35 pm-9:00 pm

1 stop6h 25m

$369

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 5/16

10:51 am-3:50 pm

1 stop4h 59m

Florence

Tue 5/19

4:02 pm-10:34 pm

2 stops6h 32m

$374

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Fri 3/13

5:30 pm-11:57 pm

1 stop6h 27m

Florence

Tue 3/17

6:15 am-1:59 pm

2 stops7h 44m

$394

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/5

12:26 pm-5:50 pm

1 stop5h 24m

Florence

Mon 3/9

6:20 pm-10:51 pm

1 stop4h 31m

$419

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 3/14

6:17 am-11:57 pm

2 stops17h 40m

Florence

Wed 3/18

6:20 pm-10:50 pm

1 stop4h 30m

$587

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 3/12

10:58 am-5:50 pm

2 stops6h 52m

Florence

Mon 3/16

6:20 pm-10:50 pm

1 stop4h 30m

$664

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/23

Sorted by cheapest first

Best time to book a flight from Maine to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Florence

What is the cheapest month to book a flight from Maine to Florence, South Carolina?

Currently, April is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $66). Flying from Maine to Florence, South Carolina in October is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Maine to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Maine?

    Most people fly into Florence (FLO) if they book a flight to Florence from Maine. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Maine to Florence, South Carolina in about 6h 58m. The time it takes to get you to your destination can typically vary by up to . The distance from Maine to Florence, South Carolina is about 735 mi.

  • Can I find deals for flights from Maine to Florence that include hotel bookings?

    Yes. In addition to deals on Maine to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Florence.

  • Can I find deals for business class flights from Maine to Florence?

    Yes. Cheapflights offers flight deals from Maine to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Maine to Florence, South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Maine to Florence, South Carolina (average of $66). Flying from Maine to Florence, South Carolina in October is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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