HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$543+ Cheap flights from Iowa to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
Aug 27 — Sep 31
Thu 8/27
Thu 9/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Florence

Cheapest flights from Iowa to Florence
Explore the most affordable flight options available from Iowa to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.

This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:09 am
MLI
-
FLO
1 stop5h 47m
American Airlines
Sat 8/153:22 pm
FLO
-
MLI
1 stop6h 51m
American Airlines
Deal found 7/24$543
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/94:21 pm
MLI
-
FLO
1 stop6h 37m
American Airlines
Sat 8/153:22 pm
FLO
-
MLI
1 stop6h 51m
American Airlines
Deal found 7/24$598
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:09 am
MLI
-
FLO
1 stop5h 47m
American Airlines
Sun 8/165:05 am
FLO
-
MLI
2 stops7h 08m
American Airlines
Deal found 7/24$603
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:00 am
MLI
-
FLO
1 stop6h 12m
American Airlines
Sun 8/165:05 am
FLO
-
MLI
2 stops7h 08m
American Airlines
Deal found 7/24$610
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:17 am
CID
-
FLO
1 stop6h 53m
American Airlines
Wed 8/53:22 pm
FLO
-
CID
1 stop4h 44m
American Airlines
Deal found 7/23$629
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:17 am
CID
-
FLO
1 stop6h 53m
American Airlines
Tue 7/282:35 pm
FLO
-
CID
2 stops10h 14m
American Airlines
Deal found 7/23$657
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:00 am
CID
-
FLO
2 stops16h 59m
American Airlines
Sat 8/156:22 am
FLO
-
CID
2 stops18h 56m
American Airlines
Deal found 7/24$693
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:44 am
CID
-
FLO
1 stop6h 28m
American Airlines
Sun 8/162:37 pm
FLO
-
CID
2 stops9h 43m
American Airlines
Deal found 7/24$777
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/91:43 pm
CID
-
FLO
2 stops9h 15m
American Airlines
Sat 8/153:22 pm
FLO
-
CID
2 stops9h 56m
American Airlines
Deal found 7/24$805

Find flight deals from Iowa to Florence

Keep the following information in mind while searching for Iowa to Florence flight deals. Data was last updated July 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$543
(American Airlines)
Provider with most accurate pricing for Des Moines-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Florence flights.
Search Deals
From Iowa to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Iowa to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

4:05 pm-10:59 pm

1 stop5h 54m

Florence

Sat 8/15

3:22 pm-12:08 am

2 stops9h 46m

$548

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

11:43 am-10:59 pm

2 stops10h 16m

Florence

Sun 8/16

5:05 am-11:13 am

2 stops7h 08m

$608
Quickest round-trip

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sun 8/9

6:44 am-2:12 pm

1 stop6h 28m

Florence

Sat 8/15

3:22 pm-9:42 pm

1 stop7h 20m

$629

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sat 8/8

1:31 pm-10:59 pm

2 stops8h 28m

Florence

Sat 8/15

3:22 pm-9:42 pm

1 stop7h 20m

$657

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sun 8/9

11:43 am-11:58 pm

2 stops11h 15m

Florence

Sat 8/15

3:22 pm-12:08 am

2 stops9h 46m

$773

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sun 8/9

11:43 am-11:58 pm

2 stops11h 15m

Florence

Sun 8/16

5:05 am-11:13 am

2 stops7h 08m

$780

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sun 8/9

5:00 am-2:12 pm

2 stops8h 12m

Florence

Sun 8/16

2:37 pm-11:20 pm

2 stops9h 43m

$905

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/24

Sorted by cheapest first

Best time to book a flight from Iowa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florence

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Iowa?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Iowa to Florence.

  • How long is the flight from Iowa to Florence, South Carolina?

    American Airlines can get you from Iowa to Florence, South Carolina in just under 5h 54m. Your travel time can differ by up to . Airlines will cover a distance of 772 mi.

  • What are the most popular routes from Iowa to Florence, South Carolina?

    When deciding which route to take from Iowa to Florence, South Carolina consider Waterloo - Florence, Cedar Rapids - Florence or Moline Quad-City - Florence as they are the most popular.

  • Can I find deals for flights from Iowa to Florence that include hotel bookings?

    Yes. In addition to deals on Iowa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florence.

  • Can I find deals for business class flights from Iowa to Florence?

    Yes. Cheapflights offers flight deals from Iowa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Charlotte flights
John F Kennedy Intl to Charlotte flights
LaGuardia to Charlotte flights
LaGuardia to Charleston flights
Newark to Charleston flights
Newark to Myrtle Beach flights
Boston to Charlotte flights
John F Kennedy Intl to Charleston flights
Dallas/Fort Worth to Charlotte flights
Boston to Charleston flights
LaGuardia to Myrtle Beach flights
John F Kennedy Intl to Myrtle Beach flights
O'Hare Intl to Charlotte flights
Newark to Savannah flights
John F Kennedy Intl to Savannah flights
Denver to Charlotte flights
Boston to Savannah flights
O'Hare Intl to Charleston flights
Detroit to Charlotte flights
Dulles Intl to Charleston flights
Dulles Intl to Charlotte flights
Minneapolis to Charlotte flights
Stewart to Myrtle Beach flights
Philadelphia to Charlotte flights
O'Hare Intl to Myrtle Beach flights
Baltimore to Charlotte flights
LaGuardia to Savannah flights
Hobby to Charlotte flights
Hartford to Myrtle Beach flights
Newark to Greenville flights
Dulles Intl to Savannah flights
Dulles Intl to Myrtle Beach flights
Akron to Myrtle Beach flights
O'Hare Intl to Savannah flights
Fort Lauderdale to Charlotte flights
George Bush Intcntl to Charlotte flights
LaGuardia to Greenville flights
Los Angeles to Charlotte flights
Detroit to Myrtle Beach flights
Minneapolis to Charleston flights
Detroit to Savannah flights
Dallas/Fort Worth to Charleston flights
Cleveland to Charlotte flights
Denver to Charleston flights
White Plains to Charleston flights
Seattle to Charlotte flights
Love Field to Charlotte flights
John F Kennedy Intl to Greenville flights
Reagan-National to Charlotte flights
Baltimore to Charleston flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.