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$481+ Cheap flights from Iowa to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
May 12 — May 191
Tue 5/12
Tue 5/19
1 adult, Economy
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Cheap flight deals from Iowa to Florence

Cheapest flights from Iowa to Florence
Explore the most affordable flight options available from Iowa to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 12, 2026.

This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:42 pm
CID
-
FLO
1 stop4h 21m
American Airlines
Wed 10/2811:07 am
FLO
-
CID
1 stop7h 27m
American Airlines
Deal found 4/11$481
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:58 am
CID
-
FLO
1 stop6h 11m
American Airlines
Mon 8/2411:15 am
FLO
-
CID
2 stops10h 34m
American Airlines
Deal found 4/6$513
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:40 am
ALO
-
FLO
2 stops15h 07m
American Airlines
Sun 4/265:20 am
FLO
-
ALO
2 stops19h 29m
American Airlines
Deal found 4/7$536

Find flight deals from Iowa to Florence

Keep the following information in mind while searching for Iowa to Florence flight deals. Data was last updated April 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$513
(American Airlines)
Provider with most accurate pricing for Des Moines-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Florence flights.
Search Deals
From Iowa to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
Use the filters below to find and compare flights from Iowa to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

WaterlooFlorence

ALO - FLO

ALOFLO

Waterloo

Wed 4/22

5:40 am-9:47 pm

2 stops15h 07m

Florence

Sun 4/26

5:20 am-11:49 pm

2 stops19h 29m

$536
Quickest round-trip

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Fri 6/12

6:44 am-2:10 pm

1 stop6h 26m

Florence

Mon 6/15

2:35 pm-11:21 pm

2 stops9h 46m

$540

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Fri 6/12

6:44 am-2:10 pm

1 stop6h 26m

Florence

Sun 6/14

2:35 pm-11:21 pm

2 stops9h 46m

$644

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/7

Sorted by cheapest first

Best time to book a flight from Iowa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florence

What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

Currently, July is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $198). Flying from Iowa to Florence, South Carolina in April is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Iowa?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Iowa to Florence.

  • How long is the flight from Iowa to Florence, South Carolina?

    American Airlines can get you from Iowa to Florence, South Carolina in just under 6h 11m. Your travel time can differ by up to . Airlines will cover a distance of 840 mi.

  • What are the most popular routes from Iowa to Florence, South Carolina?

    When deciding which route to take from Iowa to Florence, South Carolina consider Cedar Rapids - Florence, Waterloo - Florence or Moline Quad-City - Florence as they are the most popular.

  • Can I find deals for flights from Iowa to Florence that include hotel bookings?

    Yes. In addition to deals on Iowa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florence.

  • Can I find deals for business class flights from Iowa to Florence?

    Yes. Cheapflights offers flight deals from Iowa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $198). Flying from Iowa to Florence, South Carolina in April is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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