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$462+ Cheap flights from Iowa to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
Jun 29 — Jul 61
Mon 6/29
Mon 7/6
1 adult, Economy
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Cheap flight deals from Iowa to Florence

Cheapest flights from Iowa to Florence
Explore the most affordable flight options available from Iowa to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.

This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:24 pm
MLI
-
FLO
1 stop4h 36m
American Airlines
Tue 6/232:35 pm
FLO
-
MLI
2 stops10h 36m
American Airlines
Deal found 5/24$462
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:24 pm
MLI
-
FLO
1 stop4h 36m
American Airlines
Mon 6/12:35 pm
FLO
-
MLI
2 stops9h 55m
American Airlines
Deal found 5/26$496
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:24 pm
MLI
-
FLO
1 stop4h 36m
American Airlines
Mon 6/222:35 pm
FLO
-
MLI
2 stops10h 36m
American Airlines
Deal found 5/27$540
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:20 am
OMA
-
FLO
1 stop6h 50m
American Airlines
Sun 6/145:05 am
FLO
-
OMA
2 stops8h 43m
American Airlines
Deal found 5/26$595
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Tue 6/162:35 pm
FLO
-
CID
2 stops9h 56m
American Airlines
Deal found 5/29$647
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Tue 6/162:35 pm
FLO
-
CID
2 stops9h 56m
American Airlines
Deal found 5/29$667
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Tue 6/162:35 pm
FLO
-
CID
2 stops10h 16m
American Airlines
Deal found 5/29$720
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Thu 6/182:35 pm
FLO
-
CID
2 stops9h 56m
American Airlines
Deal found 5/29$747
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Thu 6/185:05 am
FLO
-
CID
2 stops7h 00m
American Airlines
Deal found 5/29$767
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1112:40 pm
CID
-
FLO
2 stops8h 20m
American Airlines
Wed 6/172:35 pm
FLO
-
CID
2 stops9h 56m
American Airlines
Deal found 5/29$795
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:44 am
CID
-
FLO
1 stop6h 26m
American Airlines
Thu 6/185:05 am
FLO
-
CID
2 stops7h 00m
American Airlines
Deal found 5/29$820

Find flight deals from Iowa to Florence

Keep the following information in mind while searching for Iowa to Florence flight deals. Data was last updated May 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$536
(American Airlines)
Provider with most accurate pricing for Des Moines-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Florence flights.
Search Deals
From Iowa to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from Iowa to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Fri 6/19

4:24 pm-10:00 pm

1 stop4h 36m

Florence

Tue 6/23

2:35 pm-12:11 am

2 stops10h 36m

$462

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Fri 6/19

4:24 pm-10:00 pm

1 stop4h 36m

Florence

Mon 6/22

2:35 pm-12:11 am

2 stops10h 36m

$540

OmahaFlorence

OMA - FLO

OMAFLO

Omaha Eppley Airfield

Wed 6/10

6:20 am-2:10 pm

1 stop6h 50m

Florence

Sun 6/14

5:05 am-12:48 pm

2 stops8h 43m

$595

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sat 6/13

12:40 pm-10:00 pm

2 stops8h 20m

Florence

Tue 6/16

2:35 pm-11:31 pm

2 stops9h 56m

$695

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Thu 6/11

6:44 am-2:10 pm

1 stop6h 26m

Florence

Tue 6/16

2:35 pm-11:51 pm

2 stops10h 16m

$720
Quickest round-trip

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Fri 6/12

6:44 am-2:10 pm

1 stop6h 26m

Florence

Thu 6/18

5:05 am-11:05 am

2 stops7h 00m

$767

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Fri 6/12

5:05 am-2:10 pm

2 stops8h 05m

Florence

Tue 6/16

2:35 pm-11:31 pm

2 stops9h 56m

$795

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Fri 6/12

5:05 am-2:10 pm

2 stops8h 05m

Florence

Wed 6/17

5:05 am-11:05 am

2 stops7h 00m

$795

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/24

Sorted by cheapest first

Best time to book a flight from Iowa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Iowa?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Iowa to Florence.

  • How long is the flight from Iowa to Florence, South Carolina?

    American Airlines can get you from Iowa to Florence, South Carolina in just under 4h 36m. Your travel time can differ by up to . Airlines will cover a distance of 772 mi.

  • What are the most popular routes from Iowa to Florence, South Carolina?

    When deciding which route to take from Iowa to Florence, South Carolina consider Moline Quad-City - Florence, Waterloo - Florence or Cedar Rapids - Florence as they are the most popular.

  • Can I find deals for flights from Iowa to Florence that include hotel bookings?

    Yes. In addition to deals on Iowa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florence.

  • Can I find deals for business class flights from Iowa to Florence?

    Yes. Cheapflights offers flight deals from Iowa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
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