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$520+ Cheap flights from Iowa to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from Iowa to Florence

Best flights from Iowa to Florence
Discover carefully curated flight deals from Iowa to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 26, 2025.

This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/163:07 pmOMA - FLO
1 stop6h 36mAmerican Airlines
Wed 1/215:36 pmFLO - OMA
1 stop5h 38mAmerican Airlines
Deal found 12/25$520
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/86:00 amCID - FLO
2 stops10h 09mAmerican Airlines
Mon 1/125:36 pmFLO - CID
1 stop6h 29mAmerican Airlines
Deal found 12/24$564

Find flight deals from Iowa to Florence

Keep the following information in mind while searching for Iowa to Florence flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$520
(American Airlines)
Provider with most accurate pricing for Des Moines-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Florence flights.
Search Deals
From Iowa to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Iowa to Florence that are best for you.

Fly from

Iowa

Fly to

Florence

Route

Depart

Return

Price

OmahaFlorence

OMA - FLO

OMAFLO

Omaha Eppley Airfield

Fri 1/16

3:07 pm-10:43 pm

1 stop6h 36m

Florence

Wed 1/21

5:36 pm-10:14 pm

1 stop5h 38m

$520

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Thu 1/8

6:00 am-5:09 pm

2 stops10h 09m

Florence

Mon 1/12

5:36 pm-11:05 pm

1 stop6h 29m

$564

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Best time to book a flight from Iowa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florence

What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $166). Flying from Iowa to Florence, South Carolina in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Iowa?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Iowa to Florence.

  • How long is the flight from Iowa to Florence, South Carolina?

    American Airlines can get you from Iowa to Florence, South Carolina in just under 6h 36m. Your travel time can differ by up to . Airlines will cover a distance of 1008 mi.

  • What are the most popular routes from Iowa to Florence, South Carolina?

    When deciding which route to take from Iowa to Florence, South Carolina consider Waterloo - Florence, Cedar Rapids - Florence or Moline Quad-City - Florence as they are the most popular.

  • Can I find deals for flights from Iowa to Florence that include hotel bookings?

    Yes. In addition to deals on Iowa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florence.

  • Can I find deals for business class flights from Iowa to Florence?

    Yes. Cheapflights offers flight deals from Iowa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $166). Flying from Iowa to Florence, South Carolina in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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