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$477+ Cheap flights from Iowa to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Iowa to Florence

Keep the following information in mind while searching for Iowa to Florence flight deals. Data was last updated September 16, 2025.

Round-trip from

$477
(American Airlines)
From Iowa to Florence
Search Deals

Find flight deals from Iowa to Florence

Cheapest flights from Iowa to Florence
Explore the most affordable flight options available from Iowa to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:28 pmCID - FLO
2 stops8h 25mAmerican Airlines
Sat 12/136:31 pmFLO - CID
1 stop6h 26mAmerican Airlines
Deal found 9/13$496
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:29 pmALO - FLO
2 stops6h 24mAmerican Airlines
Sat 12/135:15 amFLO - ALO
2 stops10h 41mAmerican Airlines
Deal found 9/13$571

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Iowa to Florence that are best for you.

Fly from

Iowa

Fly to

Florence

Route

Depart

Return

Price

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Wed 3/11

4:30 pm-11:38 pm

1 stop6h 08m

Florence

Sat 3/14

11:09 am-3:48 pm

1 stop5h 39m

$477

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Wed 12/10

1:28 pm-10:53 pm

2 stops8h 25m

Florence

Sat 12/13

6:31 pm-11:57 pm

1 stop6h 26m

$496

OmahaFlorence

OMA - FLO

OMAFLO

Omaha Eppley Airfield

Tue 2/3

6:53 am-2:01 pm

1 stop6h 08m

Florence

Sat 2/7

6:53 am-12:46 pm

1 stop6h 53m

$501

OmahaFlorence

OMA - FLO

OMAFLO

Omaha Eppley Airfield

Mon 2/2

4:25 pm-11:32 pm

1 stop6h 07m

Florence

Sat 2/7

6:53 am-12:46 pm

1 stop6h 53m

$528

OmahaFlorence

OMA - FLO

OMAFLO

Omaha Eppley Airfield

Sun 2/1

12:38 pm-11:32 pm

2 stops9h 54m

Florence

Sat 2/7

11:14 am-4:31 pm

2 stops6h 17m

$538

WaterlooFlorence

ALO - FLO

ALOFLO

Waterloo

Wed 12/10

3:29 pm-10:53 pm

2 stops6h 24m

Florence

Sat 12/13

5:15 am-2:56 pm

2 stops10h 41m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Iowa to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florence

What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $366). Flying from Iowa to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Iowa?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Iowa to Florence.

  • How long is the flight from Iowa to Florence, South Carolina?

    American Airlines can get you from Iowa to Florence, South Carolina in just under 6h 08m. Your travel time can differ by up to . Airlines will cover a distance of 772 mi.

  • What are the most popular routes from Iowa to Florence, South Carolina?

    When deciding which route to take from Iowa to Florence, South Carolina consider Waterloo - Florence, Cedar Rapids - Florence or Moline Quad-City - Florence as they are the most popular.

  • Can I find deals for flights from Iowa to Florence that include hotel bookings?

    Yes. In addition to deals on Iowa to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florence.

  • Can I find deals for business class flights from Iowa to Florence?

    Yes. Cheapflights offers flight deals from Iowa to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Iowa to Florence, South Carolina (average of $366). Flying from Iowa to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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