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$199+ Cheap flights from Harrisburg to Florence, SC (MDT - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — FLO
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
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Cheap flight deals from Harrisburg to Florence

Cheapest flights from Harrisburg to Florence
Explore the most affordable flight options available from Harrisburg to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:06 pm
MDT
-
FLO
1 stop6h 51m
American Airlines
Mon 3/306:20 pm
FLO
-
MDT
1 stop6h 15m
American Airlines
Deal found 2/19$357
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:56 pm
MDT
-
FLO
1 stop4h 01m
American Airlines
Tue 3/315:58 pm
FLO
-
MDT
1 stop5h 43m
American Airlines
Deal found 2/19$377
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/2211:24 am
MDT
-
FLO
1 stop6h 26m
American Airlines
Tue 2/246:15 am
FLO
-
MDT
1 stop5h 46m
American Airlines
Deal found 2/18$795

Find flight deals from Harrisburg to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$357
(American Airlines)

One-way from

$199
(American Airlines)
Provider with most accurate pricing for Harrisburg-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Florence flights.
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From Harrisburg to Florence
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One-way flight from Harrisburg to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Harrisburg to Florence that are best for you.

Fly from

Harrisburg

Fly to

Florence

Route

Depart

Return

Price

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Thu 3/26

5:06 pm-11:57 pm

1 stop6h 51m

Florence

Mon 3/30

6:20 pm-12:35 am

1 stop6h 15m

$357

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Fri 3/27

7:56 pm-11:57 pm

1 stop4h 01m

Florence

Tue 3/31

5:58 pm-11:41 pm

1 stop5h 43m

$377

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Sun 3/22

7:50 pm-11:57 pm

1 stop4h 07m

$199

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Compare providers for flights from Harrisburg to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Florence in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Florence

What is the cheapest month to book a flight from Harrisburg to Florence, South Carolina?

Currently, June is the cheapest month in which you can book a flight from Harrisburg to Florence, South Carolina (average of $68). Flying from Harrisburg to Florence, South Carolina in December is currently the most expensive (average of $117). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Florence, South Carolina?

    Airlines like American Airlines fly from Harrisburg to Florence, South Carolina in about 6h 51m. The time it takes to get you to your destination can typically vary by up to . Harrisburg and Florence, South Carolina are separated by a distance of 446 mi.

  • Can I find deals for flights from Harrisburg to Florence that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Florence.

  • Can I find deals for business class flights from Harrisburg to Florence?

    Yes. Cheapflights offers flight deals from Harrisburg to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Florence, South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Harrisburg to Florence, South Carolina (average of $68). Flying from Harrisburg to Florence, South Carolina in December is currently the most expensive (average of $117). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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