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$367+ Cheap flights from Fort Myers to Florence, SC (RSW - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — FLO
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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One-way flights from Fort Myers to Florence
Search for one-way flight options from Fort Myers to Florence. Find affordable one-way fares based on user searches. Data last updated September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:09 pmRSW - FLO
1 stop4h 03mAmerican Airlines
Deal found 9/17$367

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Fort Myers to Florence that are best for you.

Fly from

Fort Myers

Fly to

Florence

Route

Depart

Return

Price

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Mon 9/29

1:09 pm-5:12 pm

1 stop4h 03m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from Fort Myers to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Florence

What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $366). Flying from Fort Myers to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to FLO?

Find hourly flight availability from Fort Myers to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Fort Myers to Florence, South Carolina as you normally would.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown American Airlines from Fort Myers to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Comfort

7.2

Crew

8.0

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from Fort Myers to Florence, South Carolina round-trip?

    Currently priced at $371, American Airlines will fly you from Fort Myers to Florence, South Carolina and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip.

  • Can I find deals for flights from Fort Myers to Florence that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Florence.

  • Can I find deals for business class flights from Fort Myers to Florence?

    Yes. Cheapflights offers flight deals from Fort Myers to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $366). Flying from Fort Myers to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Fort Myers to Florence

Discover the top airline that operate flights from Fort Myers to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$371Average$472FlexibilityNo cancel feeOn-time71%

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