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$411+ Cheap flights from Fort Myers to Florence, SC (RSW - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/13. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — FLO
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Fort Myers to Florence

Best flights from Fort Myers to Florence
Discover carefully curated flight deals from Fort Myers to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 16, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:47 pmRSW - FLO
1 stop4h 11mAmerican Airlines
Wed 2/185:58 pmFLO - RSW
1 stop4h 53mAmerican Airlines
Deal found 12/15$411

Find flight deals from Fort Myers to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$411
(American Airlines)
Provider with most accurate pricing for Fort Myers SW Florida Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Florence flights.
Search Deals
From Fort Myers SW Florida Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Fort Myers to Florence that are best for you.

Fly from

Fort Myers

Fly to

Florence

Route

Depart

Return

Price

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Fri 2/13

7:47 pm-11:58 pm

1 stop4h 11m

Florence

Wed 2/18

5:58 pm-10:51 pm

1 stop4h 53m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Compare providers for flights from Fort Myers to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Florence in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Florence

What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

Currently, September is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $62). Flying from Fort Myers to Florence, South Carolina in December is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to FLO?

Find hourly flight availability from Fort Myers to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 52% on flights from Fort Myers to Florence, South Carolina by exploring options for tickets in the afternoon.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated December 16, 2025.
Read reviews from past customers who have flown American Airlines from Fort Myers to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,049 reviews

Entertainment

6.9

Comfort

7.2

Food

6.5

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
11,049 reviews
American Airlines
7.2
Good
11,049 reviews

Entertainment

6.9

Comfort

7.2

Food

6.5

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Florence, South Carolina?

    A quick flight from Fort Myers to Florence, South Carolina can take about 4h 11m. American Airlines provides one of the quickest options available for as low as $411. The distance from Fort Myers to Florence, South Carolina is about 542 mi.

  • Can I find deals for flights from Fort Myers to Florence that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Florence.

  • Can I find deals for business class flights from Fort Myers to Florence?

    Yes. Cheapflights offers flight deals from Fort Myers to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $62). Flying from Fort Myers to Florence, South Carolina in December is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Fort Myers to Florence

Discover the top airline that operate flights from Fort Myers to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$472FlexibilityNo cancel feeOn-time71%

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