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$625+ Cheap flights from Fort Myers to Florence, SC (RSW - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — FLO
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Fort Myers to Florence

Cheapest flights from Fort Myers to Florence
Explore the most affordable flight options available from Fort Myers to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:26 am
RSW
-
FLO
1 stop5h 24m
American Airlines
Fri 5/15:24 am
FLO
-
RSW
1 stop4h 12m
American Airlines
Deal found 1/26$625

Find flight deals from Fort Myers to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$625
(American Airlines)
Provider with most accurate pricing for Fort Myers SW Florida Intl-Florence flight deals.
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Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Florence flights.
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From Fort Myers SW Florida Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Fort Myers to Florence that are best for you.

Fly from

Fort Myers

Fly to

Florence

Route

Depart

Return

Price

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Sat 4/25

10:26 am-3:50 pm

1 stop5h 24m

Florence

Fri 5/1

5:24 am-9:36 am

1 stop4h 12m

$625

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

  • Most accurate provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Fort Myers-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Fort Myers-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Florence

What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

Currently, September is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $62). Flying from Fort Myers to Florence, South Carolina in December is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated January 28, 2026.
Read reviews from past customers who have flown American Airlines from Fort Myers to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,201 reviews

Overall

7.2

Food

6.4

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
American Airlines
7.2
Good
11,201 reviews
American Airlines
7.2
Good
11,201 reviews

Overall

7.2

Food

6.4

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Florence, South Carolina?

    A quick flight from Fort Myers to Florence, South Carolina can take about 5h 24m. American Airlines provides one of the quickest options available for as low as $625. The distance from Fort Myers to Florence, South Carolina is about 542 mi.

  • Can I find deals for flights from Fort Myers to Florence that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Florence.

  • Can I find deals for business class flights from Fort Myers to Florence?

    Yes. Cheapflights offers flight deals from Fort Myers to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Florence, South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Fort Myers to Florence, South Carolina (average of $62). Flying from Fort Myers to Florence, South Carolina in December is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Fort Myers to Florence

Discover the top airline that operate flights from Fort Myers to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$472FlexibilityNo cancel feeOn-time71%

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