$232+ Cheap flights from Florida to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
Dec 5 — Dec 121
Round-trip
1 adult, Economy
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Find cheap flights from Florida to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florida to Florence
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Best
Last-minute
One-way
Cheapest flights from Florida to FlorenceExplore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:37 am -
1 stop5h 36m
Sat 12/192:35 pm -
1 stop4h 19m
Deal found 11/4![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:21 am -
1 stop3h 49m
Mon 1/42:35 pm -
1 stop5h 12m
Deal found 11/3![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:15 am -
1 stop6h 02m
Mon 12/73:37 pm -
1 stop4h 33m
Deal found 11/1![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:28 pm -
1 stop4h 29m
Mon 12/212:35 pm -
1 stop6h 23m
Deal found 11/4![American Airlines logo]()
$483
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:58 am -
1 stop6h 11m
Sun 11/292:35 pm -
1 stop6h 21m
Deal found 11/4![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:06 pm -
1 stop4h 53m
Sun 11/155:09 am -
1 stop6h 32m
Deal found 11/2![American Airlines logo]()
$515
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:00 am -
1 stop4h 50m
Mon 11/305:09 am -
1 stop4h 12m
Deal found 11/4![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:51 pm -
1 stop7h 08m
Sun 11/222:35 pm -
1 stop5h 55m
Deal found 11/2![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:22 am -
1 stop5h 47m
Sat 11/143:37 pm -
1 stop4h 35m
Deal found 11/2![American Airlines logo]()
$594
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:17 am -
1 stop6h 59m
Wed 11/186:24 am -
1 stop5h 50m
Deal found 11/3![American Airlines logo]()
$843
Best flights from Florida to FlorenceDiscover carefully curated flight deals from Florida to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
Discover carefully curated flight deals from Florida to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:37 am -
1 stop5h 36m
Sat 12/192:35 pm -
1 stop4h 19m
Deal found 11/4![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:21 am -
1 stop3h 49m
Mon 1/42:35 pm -
1 stop5h 12m
Deal found 11/3![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:15 am -
1 stop6h 02m
Mon 12/73:37 pm -
1 stop4h 33m
Deal found 11/1![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:28 pm -
1 stop4h 29m
Mon 12/212:35 pm -
1 stop6h 23m
Deal found 11/4![American Airlines logo]()
$483
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2311:00 am -
1 stop4h 10m
Sat 4/105:24 am -
1 stop6h 39m
Deal found 11/1![American Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/244:37 pm -
1 stop4h 04m
Sat 4/105:24 am -
1 stop4h 12m
Deal found 11/1![American Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:58 am -
1 stop6h 11m
Sun 11/292:35 pm -
1 stop6h 21m
Deal found 11/4![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/299:10 am -
1 stop6h 00m
Tue 4/65:24 am -
1 stop4h 12m
Deal found 11/1![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/287:40 pm -
1 stop4h 17m
Wed 4/75:24 am -
1 stop4h 12m
Deal found 11/1![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:00 am -
1 stop4h 50m
Mon 11/305:09 am -
1 stop4h 12m
Deal found 11/4![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:51 pm -
1 stop7h 08m
Sun 11/222:35 pm -
1 stop5h 55m
Deal found 11/2![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:17 am -
1 stop6h 59m
Wed 11/186:24 am -
1 stop5h 50m
Deal found 11/3![American Airlines logo]()
$843
Last-minute flights from Florida to FlorenceDiscover last-minute flight deals from Florida to Florence. Data last updated November 5, 2026 and is based on user searches.
Discover last-minute flight deals from Florida to Florence. Data last updated November 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:06 pm -
1 stop4h 53m
Sun 11/155:09 am -
1 stop6h 32m
Deal found 11/2![American Airlines logo]()
$515
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:22 am -
1 stop5h 47m
Sat 11/143:37 pm -
1 stop4h 35m
Deal found 11/2![American Airlines logo]()
$594
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:17 am -
1 stop6h 59m
Wed 11/186:24 am -
1 stop5h 50m
Deal found 11/3![American Airlines logo]()
$843
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:51 pm -
1 stop7h 08m
Sun 11/222:35 pm -
1 stop5h 55m
Deal found 11/2![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:58 am -
1 stop6h 11m
Sun 11/292:35 pm -
1 stop6h 21m
Deal found 11/4![American Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:00 am -
1 stop4h 50m
Mon 11/305:09 am -
1 stop4h 12m
Deal found 11/4![American Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:15 am -
1 stop6h 02m
Mon 12/73:37 pm -
1 stop4h 33m
Deal found 11/1![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:37 am -
1 stop5h 36m
Sat 12/192:35 pm -
1 stop4h 19m
Deal found 11/4![American Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:28 pm -
1 stop4h 29m
Mon 12/212:35 pm -
1 stop6h 23m
Deal found 11/4![American Airlines logo]()
$483
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:21 am -
1 stop3h 49m
Mon 1/42:35 pm -
1 stop5h 12m
Deal found 11/3![American Airlines logo]()
$444
One-way flights from Florida to FlorenceSearch for one-way flight options from Florida to Florence. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
Search for one-way flight options from Florida to Florence. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:11 am -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$232
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:13 pm -
1 stop4h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$232
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:51 am -
1 stop4h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![American Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:58 am -
1 stop6h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:13 pm -
1 stop4h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/288:11 am -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:26 pm -
1 stop4h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$556
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:00 am -
2 stops7h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$699
Find flight deals from Florida to Florence
Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated November 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $415 (American Airlines) |
One-way from | $232 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
Use the filters below to find and compare flights from Florida to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
OrlandoFlorence
MCO Orlando - FLO Florence
MCOFLO
Orlando
Sat 11/21
8:11 am-2:09 pm
1 stop5h 58m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$232
Quickest round-trip
MiamiFlorence
MIA Miami - FLO Florence
MIAFLO
Miami
Fri 12/4
9:51 am-2:17 pm
1 stop4h 26m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$274
TampaFlorence
TPA Tampa - FLO Florence
TPAFLO
Tampa
Sat 11/21
6:00 am-2:09 pm
2 stops8h 09m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$299
TampaFlorence
TPA Tampa - FLO Florence
TPAFLO
Tampa
Sat 12/12
9:37 am-3:13 pm
1 stop5h 36m
Florence
Sat 12/19
2:35 pm-6:54 pm
1 stop4h 19m
$415
OrlandoFlorence
MCO Orlando - FLO Florence
MCOFLO
Orlando
Tue 12/29
10:21 am-2:10 pm
1 stop3h 49m
Florence
Mon 1/4
2:35 pm-7:47 pm
1 stop5h 12m
$444
OrlandoFlorence
MCO Orlando - FLO Florence
MCOFLO
Orlando
Mon 11/30
9:05 am-2:09 pm
1 stop5h 04m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$456
OrlandoFlorence
MCO Orlando - FLO Florence
MCOFLO
Orlando
Fri 11/20
7:58 am-2:09 pm
1 stop6h 11m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$456
TampaFlorence
TPA Tampa - FLO Florence
TPAFLO
Tampa
Fri 11/20
7:13 pm-11:54 pm
1 stop4h 41m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$456
OrlandoFlorence
MCO Orlando - FLO Florence
MCOFLO
Orlando
Sat 11/28
8:11 am-2:09 pm
1 stop5h 58m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$472
PensacolaFlorence
PNS Pensacola - FLO Florence
PNSFLO
Pensacola
Thu 12/3
7:15 am-2:17 pm
1 stop6h 02m
Florence
Mon 12/7
3:37 pm-7:10 pm
1 stop4h 33m
$473
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Florida to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
TPA-FLO
MCO-FLO
PNS-FLO
MIA-FLO
DJT-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florida to Florence
USFL-FLO
TPA-FLO
MCO-FLO
PNS-FLO
MIA-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
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Other flights to Florence
Explore flights to Florence departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 5, 2026.
Florida and Florence flights
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Popular flight searches
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Consider these flights traveling from Florida to Florence.
Top airline flying from Florida to Florence
Discover the top airline that operate flights from Florida to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$430 | Average$495 | FlexibilityNo cancel fee | On-time71% |