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Florence

$395+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:25 pm
PBI
-
FLO
1 stop4h 35m
American Airlines
Sat 5/305:05 am
FLO
-
PBI
1 stop4h 09m
American Airlines
Deal found 4/24$446
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:26 am
RSW
-
FLO
1 stop5h 24m
American Airlines
Wed 5/272:35 pm
FLO
-
RSW
1 stop5h 56m
American Airlines
Deal found 4/20$447
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:26 am
MIA
-
FLO
1 stop4h 24m
American Airlines
Wed 5/272:35 pm
FLO
-
MIA
1 stop5h 28m
American Airlines
Deal found 4/20$463
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:15 am
FLL
-
FLO
1 stop4h 11m
American Airlines
Tue 10/2711:07 am
FLO
-
FLL
1 stop7h 12m
American Airlines
Deal found 4/19$471
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/219:57 am
MCO
-
FLO
1 stop4h 13m
American Airlines
Mon 5/255:05 am
FLO
-
MCO
1 stop4h 01m
American Airlines
Deal found 4/20$495
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:07 am
PBI
-
FLO
1 stop4h 03m
American Airlines
Mon 5/255:05 am
FLO
-
PBI
1 stop4h 12m
American Airlines
Deal found 4/20$495
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:11 pm
FLL
-
FLO
1 stop5h 49m
American Airlines
Sun 5/315:05 am
FLO
-
FLL
1 stop4h 12m
American Airlines
Deal found 4/24$495
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:40 am
MIA
-
FLO
1 stop6h 30m
American Airlines
Mon 6/12:35 pm
FLO
-
MIA
1 stop5h 28m
American Airlines
Deal found 4/20$501
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:28 pm
MCO
-
FLO
1 stop4h 19m
American Airlines
Wed 5/134:16 pm
FLO
-
MCO
1 stop4h 25m
American Airlines
Deal found 4/24$507
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:59 am
TPA
-
FLO
1 stop4h 33m
American Airlines
Sat 5/94:16 pm
FLO
-
TPA
1 stop3h 57m
American Airlines
Deal found 4/20$507
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:06 pm
MCO
-
FLO
1 stop6h 41m
American Airlines
Sun 5/104:16 pm
FLO
-
MCO
1 stop4h 25m
American Airlines
Deal found 4/21$542
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:51 am
TPA
-
FLO
1 stop4h 59m
American Airlines
Sun 5/105:20 am
FLO
-
TPA
1 stop4h 35m
American Airlines
Deal found 4/21$542

Find flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$446
(American Airlines)

One-way from

$395
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
Search Deals
From Florida to Florence
Search Deals
One-way flight from Florida to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Sun 5/24

5:25 pm-10:00 pm

1 stop4h 35m

Florence

Sat 5/30

5:05 am-9:14 am

1 stop4h 09m

$446

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 5/20

10:26 am-3:50 pm

1 stop5h 24m

Florence

Wed 5/27

2:35 pm-8:31 pm

1 stop5h 56m

$447

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 5/22

9:57 am-2:10 pm

1 stop4h 13m

Florence

Mon 5/25

5:05 am-9:06 am

1 stop4h 01m

$495

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Thu 5/21

10:07 am-2:10 pm

1 stop4h 03m

Florence

Mon 5/25

5:05 am-9:17 am

1 stop4h 12m

$495

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Mon 5/25

4:11 pm-10:00 pm

1 stop5h 49m

Florence

Sun 5/31

5:05 am-9:17 am

1 stop4h 12m

$495

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 5/21

10:58 am-10:00 pm

2 stops11h 02m

Florence

Mon 5/25

5:05 am-9:06 am

1 stop4h 01m

$500

MiamiFlorence

MIA - FLO

MIAFLO

Miami

Sat 5/30

7:40 am-2:10 pm

1 stop6h 30m

Florence

Mon 6/1

2:35 pm-8:03 pm

1 stop5h 28m

$501

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 5/9

5:28 pm-9:47 pm

1 stop4h 19m

Florence

Wed 5/13

4:16 pm-8:41 pm

1 stop4h 25m

$507

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Tue 5/5

7:00 am-3:32 pm

2 stops8h 32m

Florence

Sat 5/9

5:20 am-10:49 am

1 stop5h 29m

$512

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 5/6

3:06 pm-9:47 pm

1 stop6h 41m

Florence

Sun 5/10

4:16 pm-8:41 pm

1 stop4h 25m

$542

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 48 resultsSorted by cheapest first
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Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Florida to Florence, South Carolina?

    There are many flights that can get you from Florida to Florence, South Carolina in 4h 35m. Fly via American Airlines to get the fastest option. Florida and Florence, South Carolina are separated by a distance of 518 mi.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Fort Lauderdale - Florence, Palm Beach Intl - Florence or Miami - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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