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$481+ Cheap flights from Columbus to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — FLO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Columbus to Florence

Cheapest flights from Columbus to Florence
Explore the most affordable flight options available from Columbus to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/298:35 amCMH - FLO
1 stop6h 19mAmerican Airlines
Sat 11/111:11 amFLO - CMH
1 stop3h 21mAmerican Airlines
Deal found 10/28$481
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:27 pmCMH - FLO
1 stop3h 26mAmerican Airlines
Sun 11/165:15 amFLO - CMH
1 stop5h 08mAmerican Airlines
Deal found 10/28$529
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:17 pmCMH - FLO
1 stop3h 46mAmerican Airlines
Mon 11/1710:29 amFLO - CMH
1 stop5h 44mAmerican Airlines
Deal found 10/29$559
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:54 pmCMH - FLO
2 stops7h 19mAmerican Airlines
Sun 11/25:15 amFLO - CMH
1 stop5h 08mAmerican Airlines
Deal found 10/30$564
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:02 pmCMH - FLO
1 stop5h 39mAmerican Airlines
Sun 11/306:33 pmFLO - CMH
1 stop3h 57mAmerican Airlines
Deal found 10/27$575

Cheap flight deals from Columbus to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Round-trip from

$559
(American Airlines)
From Columbus to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Columbus to Florence that are best for you.

Fly from

Columbus

Fly to

Florence

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 11/12

7:27 pm-10:53 pm

1 stop3h 26m

Florence

Sun 11/16

5:15 am-10:23 am

1 stop5h 08m

$529

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Thu 11/13

8:17 pm-12:03 am

1 stop3h 46m

Florence

Mon 11/17

10:29 am-4:13 pm

1 stop5h 44m

$559

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 11/28

2:34 pm-11:41 pm

2 stops9h 07m

Florence

Sun 11/30

6:33 pm-12:37 am

1 stop6h 04m

$580

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Best time to book a flight from Columbus to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Florence

What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $80). Flying from Columbus to Florence, South Carolina in February is currently the most expensive (average of $144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Columbus?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Columbus to Florence. 0 airlines have flights to Florence from Columbus on a regular basis. Booking flights from Columbus to Florence should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

  • How long is the flight from Columbus to Florence, South Carolina?

    There are many flights that can get you from Columbus to Florence, South Carolina in 3h 26m. Fly via American Airlines to get the fastest option. Airlines will cover a distance of 438 mi.

  • Can I find deals for flights from Columbus to Florence that include hotel bookings?

    Yes. In addition to deals on Columbus to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Florence.

  • Can I find deals for business class flights from Columbus to Florence?

    Yes. Cheapflights offers flight deals from Columbus to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $80). Flying from Columbus to Florence, South Carolina in February is currently the most expensive (average of $144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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