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$535+ Cheap flights from Columbus to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — FLO
Apr 26 — May 31
Sun 4/26
Sun 5/3
1 adult, Economy
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Cheap flight deals from Columbus to Florence

Cheapest flights from Columbus to Florence
Explore the most affordable flight options available from Columbus to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 27, 2026.

This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:31 am
CMH
-
FLO
1 stop3h 38m
American Airlines
Fri 9/116:31 pm
FLO
-
CMH
1 stop5h 31m
American Airlines
Deal found 3/24$535
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:58 am
CMH
-
FLO
1 stop3h 11m
American Airlines
Sun 10/185:22 am
FLO
-
CMH
1 stop3h 22m
American Airlines
Deal found 3/24$585
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:43 pm
CMH
-
FLO
1 stop6h 14m
American Airlines
Fri 4/104:16 pm
FLO
-
CMH
1 stop5h 28m
American Airlines
Deal found 3/22$935

Find flight deals from Columbus to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 27, 2026.

Round-trip from

$535
(American Airlines)
From Columbus to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Columbus to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 8/29

10:31 am-2:09 pm

1 stop3h 38m

Florence

Fri 9/11

6:31 pm-12:02 am

1 stop5h 31m

$535

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Mon 4/6

5:43 pm-11:57 pm

1 stop6h 14m

Florence

Fri 4/10

4:16 pm-9:44 pm

1 stop5h 28m

$935

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Sorted by cheapest first

Best time to book a flight from Columbus to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Florence

What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $90). Flying from Columbus to Florence, South Carolina in December is currently the most expensive (average of $128). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Columbus?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Columbus to Florence. 1 airline have flights to Florence from Columbus on a regular basis. Booking flights from Columbus to Florence should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

  • How long is the flight from Columbus to Florence, South Carolina?

    There are many flights that can get you from Columbus to Florence, South Carolina in 3h 38m. Fly via American Airlines to get the fastest option. Airlines will cover a distance of 438 mi.

  • Can I find deals for flights from Columbus to Florence that include hotel bookings?

    Yes. In addition to deals on Columbus to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Florence.

  • Can I find deals for business class flights from Columbus to Florence?

    Yes. Cheapflights offers flight deals from Columbus to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $90). Flying from Columbus to Florence, South Carolina in December is currently the most expensive (average of $128). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Columbus to Florence

Discover the top airline that operate flights from Columbus to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$420Average$578FlexibilityNo cancel feeOn-time71%

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