HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$579+ Cheap flights from Columbus to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — FLO
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Columbus to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Columbus to Florence

Cheapest flights from Columbus to Florence
Explore the most affordable flight options available from Columbus to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/291:05 pm
CMH
-
FLO
1 stop4h 04m
American Airlines
Sun 2/15:36 pm
FLO
-
CMH
1 stop5h 46m
American Airlines
Deal found 1/27$579
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/306:10 am
CMH
-
FLO
2 stops10h 59m
American Airlines
Sun 2/16:15 am
FLO
-
CMH
2 stops7h 54m
American Airlines
Deal found 1/26$590
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1210:30 am
CMH
-
FLO
2 stops7h 20m
American Airlines
Mon 2/165:16 am
FLO
-
CMH
2 stops8h 42m
American Airlines
Deal found 1/28$643

Find flight deals from Columbus to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Round-trip from

$579
(American Airlines)
From Columbus to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Columbus to Florence that are best for you.

Fly from

Columbus

Fly to

Florence

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Thu 2/12

11:55 am-5:50 pm

1 stop5h 55m

Florence

Mon 2/16

6:20 pm-12:26 am

1 stop6h 06m

$579

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Best time to book a flight from Columbus to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Florence

What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $90). Flying from Columbus to Florence, South Carolina in April is currently the most expensive (average of $128). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Columbus?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Columbus to Florence. 0 airlines have flights to Florence from Columbus on a regular basis. Booking flights from Columbus to Florence should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

  • How long is the flight from Columbus to Florence, South Carolina?

    There are many flights that can get you from Columbus to Florence, South Carolina in 5h 55m. Fly via American Airlines to get the fastest option. Airlines will cover a distance of 438 mi.

  • Can I find deals for flights from Columbus to Florence that include hotel bookings?

    Yes. In addition to deals on Columbus to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Florence.

  • Can I find deals for business class flights from Columbus to Florence?

    Yes. Cheapflights offers flight deals from Columbus to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Columbus to Florence, South Carolina (average of $90). Flying from Columbus to Florence, South Carolina in April is currently the most expensive (average of $128). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbus to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Detroit to Charlotte flights
Detroit to Myrtle Beach flights
Detroit to Charleston flights
Detroit to Savannah flights
Cleveland to Charlotte flights
Pittsburgh to Myrtle Beach flights
Cleveland to Myrtle Beach flights
Cleveland to Charleston flights
Akron to Charleston flights
Cincinnati to Charlotte flights
Akron to Myrtle Beach flights
Columbus to Savannah flights
Cleveland to Savannah flights
Pittsburgh to Charlotte flights
Pittsburgh to Charleston flights
Columbus to Myrtle Beach flights
Akron to Charlotte flights
Pittsburgh to Columbia flights
Akron to Savannah flights
Columbus to Charleston flights
Cincinnati to Charleston flights
Columbus to Charlotte flights
Detroit to Greenville flights
Cincinnati to Hilton Head Island flights
Cleveland to Hilton Head Island flights
Pittsburgh to Savannah flights
Cincinnati to Myrtle Beach flights
Cincinnati to Savannah flights
Columbus to Hilton Head Island flights
Detroit to Hilton Head Island flights
Dayton to Charleston flights
Dayton to Charlotte flights
Akron to Hilton Head Island flights
Pittsburgh to Augusta flights
Cleveland to Greenville flights
Cleveland to Columbia flights
Pittsburgh to Hilton Head Island flights
Akron to Columbia flights
Detroit to Columbia flights
Columbus to Columbia flights
Cincinnati to Greenville flights
Dayton to Myrtle Beach flights
Detroit to Augusta flights
Pittsburgh to Greenville flights
Cincinnati to Columbia flights
Dayton to Savannah flights
Columbus to Greenville flights
Dayton to Greenville flights
Cleveland to Augusta flights
Dayton to Columbia flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.