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$519+ Cheap flights from Colorado to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Colorado to Florence

Keep the following information in mind while searching for Colorado to Florence flight deals. Data was last updated September 15, 2025.

Round-trip from

$519
(American Airlines)
From Colorado to Florence
Search Deals

Find flight deals from Colorado to Florence

Cheapest flights from Colorado to Florence
Explore the most affordable flight options available from Colorado to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:09 amDEN - FLO
1 stop8h 03mAmerican Airlines
Sat 10/1111:11 amFLO - DEN
1 stop5h 59mAmerican Airlines
Deal found 9/14$519
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:27 amCOS - FLO
2 stops11h 48mAmerican Airlines
Tue 12/166:15 amFLO - COS
2 stops11h 30mAmerican Airlines
Deal found 9/13$555
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/161:52 pmDEN - FLO
1 stop8h 11mAmerican Airlines
Sun 10/192:29 pmFLO - DEN
1 stop7h 39mAmerican Airlines
Deal found 9/14$565
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:38 amGJT - FLO
2 stops10h 15mAmerican Airlines
Sat 12/1311:16 amFLO - GJT
2 stops11h 33mAmerican Airlines
Deal found 9/13$571
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:00 amMTJ - FLO
2 stops9h 04mAmerican Airlines
Wed 11/1210:29 amFLO - MTJ
2 stops10h 50mAmerican Airlines
Deal found 9/13$621
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/297:16 amDEN - FLO
2 stops14h 00mAmerican Airlines
Fri 10/312:27 pmFLO - DEN
2 stops11h 49mAmerican Airlines
Deal found 9/14$784

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Colorado to Florence that are best for you.

Fly from

Colorado

Fly to

Florence

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 10/4

7:09 am-5:12 pm

1 stop8h 03m

Florence

Sat 10/11

11:11 am-3:10 pm

1 stop5h 59m

$519

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Sat 12/13

10:27 am-12:15 am

2 stops11h 48m

Florence

Tue 12/16

6:15 am-3:45 pm

2 stops11h 30m

$555

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 10/16

1:52 pm-12:03 am

1 stop8h 11m

Florence

Sun 10/19

2:29 pm-8:08 pm

1 stop7h 39m

$565

Grand JunctionFlorence

GJT - FLO

GJTFLO

Grand Junction Regnl

Wed 12/10

10:38 am-10:53 pm

2 stops10h 15m

Florence

Sat 12/13

11:16 am-8:49 pm

2 stops11h 33m

$571

MontroseFlorence

MTJ - FLO

MTJFLO

Montrose County

Sat 11/8

7:00 am-6:04 pm

2 stops9h 04m

Florence

Wed 11/12

10:29 am-7:19 pm

2 stops10h 50m

$621

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Mon 9/29

7:16 am-11:16 pm

2 stops14h 00m

Florence

Fri 10/3

12:27 pm-10:16 pm

2 stops11h 49m

$784

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Colorado to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Florence

What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $366). Flying from Colorado to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to FLO?

Find hourly flight availability from Colorado to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Colorado to Florence, South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Colorado to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Colorado?

    Most people fly into Florence (FLO) if they book a flight to Florence from Colorado. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Colorado to Florence, South Carolina?

    For as low as $519, American Airlines can have you in Florence, South Carolina from Colorado in 8h 03m. There are 1425 mi between Colorado and Florence, South Carolina.

  • What are the most popular routes from Colorado to Florence, South Carolina?

    The most popular route from Colorado to Florence, South Carolina is Denver Intl - Florence. You may also consider Colorado Springs - Florence or Grand Junction Regnl - Florence.

  • Can I find deals for flights from Colorado to Florence that include hotel bookings?

    Yes. In addition to deals on Colorado to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Florence.

  • Can I find deals for business class flights from Colorado to Florence?

    Yes. Cheapflights offers flight deals from Colorado to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $366). Flying from Colorado to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Colorado to Florence

Discover the top airline that operate flights from Colorado to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$385Average$481FlexibilityNo cancel feeOn-time71%

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