HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$365+ Cheap flights from Colorado to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
ต.ค. 13 — ต.ค. 201
จ. 10/13
จ. 10/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Colorado to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Colorado to Florence

Keep the following information in mind while searching for Colorado to Florence flight deals. Data was last updated กันยายน 13, 2025.

Round-trip from

$365
(American Airlines)
From Colorado to Florence
Search Deals

Find flight deals from Colorado to Florence

Cheapest flights from Colorado to Florence
Explore the most affordable flight options available from Colorado to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on กันยายน 13, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ส. 9/273:08 pmDEN - FLO
1 stop6h 08mAmerican Airlines
พ. 10/16:14 amFLO - DEN
2 stops14h 22mAmerican Airlines
Deal found 9/11$392
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ส. 9/137:09 amDEN - FLO
1 stop8h 03mAmerican Airlines
พ. 9/245:37 pmFLO - DEN
1 stop6h 36mAmerican Airlines
Deal found 9/11$519
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ส. 12/1312:45 pmCOS - FLO
2 stops9h 30mAmerican Airlines
อ. 12/1611:15 amFLO - COS
2 stops26h 51mAmerican Airlines
Deal found 9/12$530
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ส. 11/157:00 amMTJ - FLO
2 stops9h 04mAmerican Airlines
อ. 11/1811:14 amFLO - MTJ
2 stops10h 05mAmerican Airlines
Deal found 9/10$571
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
พ. 12/1010:38 amGJT - FLO
2 stops10h 15mAmerican Airlines
ส. 12/135:15 amFLO - GJT
2 stops12h 47mAmerican Airlines
Deal found 9/10$571
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ส. 11/87:00 amMTJ - FLO
2 stops9h 04mAmerican Airlines
พ. 11/1210:29 amFLO - MTJ
2 stops10h 50mAmerican Airlines
Deal found 9/11$621
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
พฤ. 10/165:28 pmDEN - FLO
2 stops15h 18mAmerican Airlines
อา. 10/195:14 amFLO - DEN
1 stop5h 48mAmerican Airlines
Deal found 9/11$621
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ศ. 10/176:44 pmDEN - FLO
2 stops14h 02mAmerican Airlines
อา. 10/195:14 amFLO - DEN
1 stop5h 48mAmerican Airlines
Deal found 9/11$669

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated กันยายน 13, 2025.
Use the filters below to find and compare flights from Colorado to Florence that are best for you.

Fly from

Colorado

Fly to

Florence

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

ส. 2/7

7:22 am-11:32 pm

2 stops14h 10m

Florence

ส. 2/14

11:11 am-6:03 pm

1 stop8h 52m

$365

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

ส. 9/27

3:08 pm-11:16 pm

1 stop6h 08m

Florence

พ. 10/1

6:14 am-6:36 pm

2 stops14h 22m

$392

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

ส. 12/13

12:45 pm-12:15 am

2 stops9h 30m

Florence

อ. 12/16

11:15 am-12:06 pm

2 stops26h 51m

$530

MontroseFlorence

MTJ - FLO

MTJFLO

Montrose County

ส. 11/15

7:00 am-6:04 pm

2 stops9h 04m

Florence

อ. 11/18

11:14 am-7:19 pm

2 stops10h 05m

$571

Grand JunctionFlorence

GJT - FLO

GJTFLO

Grand Junction Regnl

พ. 12/10

10:38 am-10:53 pm

2 stops10h 15m

Florence

ส. 12/13

5:15 am-4:02 pm

2 stops12h 47m

$571

MontroseFlorence

MTJ - FLO

MTJFLO

Montrose County

ส. 11/8

7:00 am-6:04 pm

2 stops9h 04m

Florence

พ. 11/12

10:29 am-7:19 pm

2 stops10h 50m

$621

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

พฤ. 10/16

5:28 pm-10:46 am

2 stops15h 18m

Florence

อา. 10/19

5:14 am-9:02 am

1 stop5h 48m

$621

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

ศ. 10/17

4:41 pm-12:03 am

1 stop5h 22m

Florence

อา. 10/19

5:14 am-9:02 am

1 stop5h 48m

$645

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Colorado to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Florence

What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $366). Flying from Colorado to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to FLO?

Find hourly flight availability from Colorado to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated กันยายน 13, 2025.

When flying from Colorado to Florence, South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Colorado to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Colorado?

    Most people fly into Florence (FLO) if they book a flight to Florence from Colorado. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Colorado to Florence, South Carolina?

    For as low as $365, American Airlines can have you in Florence, South Carolina from Colorado in 14h 10m. There are 1425 mi between Colorado and Florence, South Carolina.

  • What are the most popular routes from Colorado to Florence, South Carolina?

    The most popular route from Colorado to Florence, South Carolina is Denver Intl - Florence. You may also consider Colorado Springs - Florence or Grand Junction Regnl - Florence.

  • Can I find deals for flights from Colorado to Florence that include hotel bookings?

    Yes. In addition to deals on Colorado to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Florence.

  • Can I find deals for business class flights from Colorado to Florence?

    Yes. Cheapflights offers flight deals from Colorado to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $366). Flying from Colorado to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Colorado to Florence

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Charlotte flights
John F Kennedy Intl to Charleston flights
Newark to Charlotte flights
Boston to Charlotte flights
Newark to Charleston flights
LaGuardia to Charlotte flights
Dallas/Fort Worth to Charlotte flights
LaGuardia to Charleston flights
Boston to Charleston flights
O'Hare Intl to Charlotte flights
Denver to Charlotte flights
Philadelphia to Charlotte flights
Newark to Savannah flights
Baltimore to Charlotte flights
O'Hare Intl to Charleston flights
John F Kennedy Intl to Savannah flights
Newark to Myrtle Beach flights
Reagan-National to Charleston flights
Minneapolis to Charlotte flights
Dulles Intl to Charlotte flights
Dulles Intl to Charleston flights
LaGuardia to Myrtle Beach flights
Philadelphia to Charleston flights
LaGuardia to Savannah flights
John F Kennedy Intl to Myrtle Beach flights
Los Angeles to Charlotte flights
Boston to Savannah flights
Seattle to Charlotte flights
Baltimore to Charleston flights
LaGuardia to Columbia flights
O'Hare Intl to Savannah flights
LaGuardia to Greenville flights
Minneapolis to Charleston flights
Philadelphia to Savannah flights
Minneapolis to Savannah flights
Newark to Greenville flights
Providence to Charleston flights
Fort Lauderdale to Charlotte flights
Reagan-National to Charlotte flights
White Plains to Charleston flights
John F Kennedy Intl to Greenville flights
Miami to Charlotte flights
White Plains to Myrtle Beach flights
San Francisco to Charlotte flights
Denver to Charleston flights
Providence to Charlotte flights
Boston to Myrtle Beach flights
Dallas/Fort Worth to Charleston flights
Buffalo to Charlotte flights
Detroit to Charlotte flights

Top airline flying from Colorado to Florence

Discover the top airline that operate flights from Colorado to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated กันยายน 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$385Average$481FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.