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Florence

$271+ Cheap flights from Colorado to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Colorado to Florence

Cheapest flights from Colorado to Florence
Explore the most affordable flight options available from Colorado to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:38 am
DEN
-
FLO
1 stop5h 32m
American Airlines
Sat 5/302:35 pm
FLO
-
DEN
1 stop7h 38m
American Airlines
Deal found 2/24$481
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:50 pm
DEN
-
FLO
1 stop8h 12m
American Airlines
Wed 9/2311:20 am
FLO
-
DEN
1 stop5h 10m
American Airlines
Deal found 2/26$501
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/134:03 pm
DEN
-
FLO
1 stop5h 54m
American Airlines
Sun 3/156:20 pm
FLO
-
DEN
1 stop6h 22m
American Airlines
Deal found 2/27$583
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
DEN
-
FLO
2 stops9h 21m
American Airlines
Wed 3/116:20 pm
FLO
-
DEN
1 stop6h 22m
American Airlines
Deal found 2/27$584
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:03 pm
DEN
-
FLO
1 stop5h 54m
American Airlines
Sat 3/146:25 pm
FLO
-
DEN
1 stop6h 17m
American Airlines
Deal found 2/24$621
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/218:07 am
DEN
-
FLO
1 stop7h 43m
American Airlines
Sat 3/286:25 pm
FLO
-
DEN
1 stop6h 17m
American Airlines
Deal found 2/26$638
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:00 am
COS
-
FLO
2 stops9h 50m
American Airlines
Mon 3/166:20 pm
FLO
-
COS
2 stops17h 30m
American Airlines
Deal found 2/25$740
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:57 pm
COS
-
FLO
2 stops9h 00m
American Airlines
Fri 6/52:35 pm
FLO
-
COS
2 stops9h 50m
American Airlines
Deal found 2/26$1,097

Find flight deals from Colorado to Florence

Keep the following information in mind while searching for Colorado to Florence flight deals. Data was last updated February 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$481
(American Airlines)

One-way from

$271
(American Airlines)
Provider with most accurate pricing for Denver Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Florence flights.
Search Deals
From Colorado to Florence
Search Deals
One-way flight from Colorado to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Colorado to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 5/23

6:38 am-2:10 pm

1 stop5h 32m

Florence

Sat 5/30

2:35 pm-8:13 pm

1 stop7h 38m

$481

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 3/4

6:00 am-5:21 pm

2 stops9h 21m

Florence

Wed 3/11

5:16 am-1:57 pm

2 stops10h 41m

$589

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 3/5

4:03 pm-11:57 pm

1 stop5h 54m

Florence

Sat 3/14

6:25 pm-10:42 pm

1 stop6h 17m

$621

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 3/21

8:07 am-5:50 pm

1 stop7h 43m

Florence

Sat 3/28

6:25 pm-10:42 pm

1 stop6h 17m

$638

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 3/13

4:03 pm-11:57 pm

1 stop5h 54m

Florence

Sun 3/15

5:16 am-5:17 pm

2 stops14h 01m

$703

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 3/15

7:00 am-11:57 pm

2 stops14h 57m

Florence

Thu 3/19

5:16 am-5:17 pm

2 stops14h 01m

$974

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Thu 3/12

6:00 am-5:50 pm

2 stops9h 50m

Florence

Mon 3/16

5:16 am-12:48 pm

3 stops9h 32m

$1,052

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Mon 6/1

12:57 pm-11:57 pm

2 stops9h 00m

Florence

Fri 6/5

2:35 pm-10:25 pm

2 stops9h 50m

$1,097

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 6/16

1:57 pm-11:57 pm

1 stop8h 00m

$500

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 3/10

9:30 am-5:21 pm

1 stop5h 51m

$500

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/26

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Best time to book a flight from Colorado to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Florence

What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $72). Flying from Colorado to Florence, South Carolina in July is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Colorado to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Colorado?

    Most people fly into Florence (FLO) if they book a flight to Florence from Colorado. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Colorado to Florence, South Carolina?

    For as low as $481, American Airlines can have you in Florence, South Carolina from Colorado in 5h 32m. There are 1425 mi between Colorado and Florence, South Carolina.

  • What are the most popular routes from Colorado to Florence, South Carolina?

    The most popular route from Colorado to Florence, South Carolina is Denver Intl - Florence. You may also consider Colorado Springs - Florence or Grand Junction Regnl - Florence.

  • Can I find deals for flights from Colorado to Florence that include hotel bookings?

    Yes. In addition to deals on Colorado to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Florence.

  • Can I find deals for business class flights from Colorado to Florence?

    Yes. Cheapflights offers flight deals from Colorado to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $72). Flying from Colorado to Florence, South Carolina in July is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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