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$653+ Cheap flights from Colorado to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/3. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
Jan 20 — Jan 271
Tue 1/20
Tue 1/27
1 adult, Economy
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Cheap flight deals from Colorado to Florence

Best flights from Colorado to Florence
Discover carefully curated flight deals from Colorado to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 21, 2025.

This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/38:07 amDEN - FLO
1 stop7h 58mAmerican Airlines
Wed 1/76:15 amFLO - DEN
1 stop6h 16mAmerican Airlines
Deal found 12/18$657

Find flight deals from Colorado to Florence

Keep the following information in mind while searching for Colorado to Florence flight deals. Data was last updated December 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$653
(American Airlines)
Provider with most accurate pricing for Denver Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Florence flights.
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From Colorado to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Colorado to Florence that are best for you.

Fly from

Colorado

Fly to

Florence

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 1/3

8:07 am-6:05 pm

1 stop7h 58m

Florence

Wed 1/7

6:15 am-10:31 am

1 stop6h 16m

$657

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Best time to book a flight from Colorado to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Florence

What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $77). Flying from Colorado to Florence, South Carolina in July is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to FLO?

Find hourly flight availability from Colorado to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 21, 2025.

When flying from Colorado to Florence, South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 18% versus a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from Colorado to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Colorado?

    Most people fly into Florence (FLO) if they book a flight to Florence from Colorado. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Colorado to Florence, South Carolina?

    For as low as $657, American Airlines can have you in Florence, South Carolina from Colorado in 7h 58m. There are 1425 mi between Colorado and Florence, South Carolina.

  • What are the most popular routes from Colorado to Florence, South Carolina?

    The most popular route from Colorado to Florence, South Carolina is Colorado Springs - Florence. You may also consider Denver Intl - Florence or Grand Junction Regnl - Florence.

  • Can I find deals for flights from Colorado to Florence that include hotel bookings?

    Yes. In addition to deals on Colorado to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Florence.

  • Can I find deals for business class flights from Colorado to Florence?

    Yes. Cheapflights offers flight deals from Colorado to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Colorado to Florence, South Carolina (average of $77). Flying from Colorado to Florence, South Carolina in July is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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