$233+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Sep 30 — Oct 71
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to Florence
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Cheapest flights from Chicago to FlorenceExplore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 31, 2026.
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 31, 2026.
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/284:45 pm -
1 stop5h 13m
Sat 10/102:34 pm -
1 stop6h 17m
Deal found 8/26![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:40 pm -
1 stop4h 17m
Fri 10/235:09 am -
1 stop5h 01m
Deal found 8/26![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 8/31![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:29 am -
1 stop5h 49m
Thu 10/16:24 am -
1 stop6h 50m
Deal found 8/26![American Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:45 pm -
1 stop6h 12m
Sun 10/185:09 am -
1 stop5h 01m
Deal found 8/28![American Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:29 am -
1 stop6h 40m
Sun 10/185:09 am -
1 stop5h 01m
Deal found 8/27![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:05 am -
1 stop4h 13m
Mon 9/211:43 pm -
1 stop4h 55m
Deal found 8/30![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 8/31![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:20 am -
1 stop6h 58m
Mon 10/55:09 am -
1 stop5h 01m
Deal found 8/31![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/124:45 pm -
1 stop6h 12m
Mon 10/192:34 pm -
1 stop6h 17m
Deal found 8/28![American Airlines logo]()
$660
Best flights from Chicago to FlorenceDiscover carefully curated flight deals from Chicago to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 31, 2026.
Discover carefully curated flight deals from Chicago to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 31, 2026.
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/284:45 pm -
1 stop5h 13m
Sat 10/102:34 pm -
1 stop6h 17m
Deal found 8/26![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:29 am -
1 stop5h 49m
Sun 10/45:09 am -
1 stop4h 51m
Deal found 8/31![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:29 am -
1 stop5h 49m
Thu 10/16:24 am -
1 stop6h 50m
Deal found 8/26![American Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:45 pm -
1 stop6h 12m
Sun 10/185:09 am -
1 stop5h 01m
Deal found 8/28![American Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:05 am -
1 stop4h 13m
Mon 9/211:43 pm -
1 stop4h 55m
Deal found 8/30![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:20 am -
1 stop6h 58m
Mon 10/55:09 am -
1 stop5h 01m
Deal found 8/31![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:29 am -
1 stop6h 40m
Sun 11/12:35 pm -
2 stops7h 54m
Deal found 8/26![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:29 am -
1 stop6h 40m
Sun 10/185:09 am -
2 stops7h 37m
Deal found 8/27![American Airlines logo]()
$694
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:37 pm -
2 stops7h 20m
Mon 10/192:34 pm -
1 stop4h 17m
Deal found 8/28![American Airlines logo]()
$763
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:59 pm -
2 stops6h 59m
Mon 9/146:24 am -
2 stops6h 52m
Deal found 8/30![American Airlines logo]()
$863
Last-minute flights from Chicago to FlorenceDiscover last-minute flight deals from Chicago to Florence. Data last updated August 31, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to Florence. Data last updated August 31, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:29 am -
1 stop5h 49m
Mon 9/146:24 am -
2 stops6h 52m
Deal found 8/26![American Airlines logo]()
$752
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:20 am -
1 stop6h 58m
Mon 9/146:24 am -
2 stops7h 26m
Deal found 8/30![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:05 am -
1 stop4h 13m
Mon 9/211:43 pm -
1 stop4h 55m
Deal found 8/30![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:29 am -
1 stop5h 49m
Thu 10/16:24 am -
1 stop6h 50m
Deal found 8/26![American Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/284:45 pm -
1 stop5h 13m
Sat 10/102:34 pm -
1 stop6h 17m
Deal found 8/26![American Airlines logo]()
$375
One-way flights from Chicago to FlorenceSearch for one-way flight options from Chicago to Florence. Find affordable one-way fares based on user searches. Data last updated August 31, 2026.
Search for one-way flight options from Chicago to Florence. Find affordable one-way fares based on user searches. Data last updated August 31, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:05 am -
1 stop4h 13m
Deal found 8/27![American Airlines logo]()
$233
Find flight deals from Chicago to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 31, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (American Airlines) |
One-way from | $233 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 31, 2026.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Mon 9/28
4:45 pm-10:58 pm
1 stop5h 13m
Florence
Sat 10/10
2:34 pm-7:51 pm
1 stop6h 17m
$375
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 10/1
6:29 am-1:18 pm
1 stop5h 49m
Florence
Sun 10/4
5:09 am-9:00 am
1 stop4h 51m
$409
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 9/24
6:29 am-1:18 pm
1 stop5h 49m
Florence
Thu 10/1
6:24 am-12:14 pm
1 stop6h 50m
$420
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/16
4:45 pm-11:57 pm
1 stop6h 12m
Florence
Sun 10/18
5:09 am-9:10 am
1 stop5h 01m
$421
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 9/18
8:05 am-1:18 pm
1 stop4h 13m
Florence
Mon 9/21
1:43 pm-5:38 pm
1 stop4h 55m
$486
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/2
5:20 am-1:18 pm
1 stop6h 58m
Florence
Mon 10/5
5:09 am-9:10 am
1 stop5h 01m
$569
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Thu 10/29
6:29 am-2:09 pm
1 stop6h 40m
Florence
Sun 11/1
2:35 pm-9:29 pm
2 stops7h 54m
$649
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sun 10/11
6:29 am-2:09 pm
1 stop6h 40m
Florence
Sun 10/18
5:09 am-11:46 am
2 stops7h 37m
$694
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Mon 10/12
3:37 pm-11:57 pm
2 stops7h 20m
Florence
Mon 10/19
2:34 pm-5:51 pm
1 stop4h 17m
$763
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 9/11
2:59 pm-10:58 pm
2 stops6h 59m
Florence
Mon 9/14
6:24 am-12:16 pm
2 stops6h 52m
$863
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Chicago to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Florence in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Chicago-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Chicago to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
CHI-FLO
ORD-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to Florence
CHI-FLO
ORD-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
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