$122+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Dec 12 — Dec 191
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
1 stop26h 48m
Mon 12/146:12 pm -
2 stops28h 48m
Deal found 11/8![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
1 stop13h 54m
Mon 12/148:58 pm -
2 stops26h 02m
Deal found 11/9![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:15 am -
2 stops23h 23m
Wed 12/28:09 pm -
1 stop18h 51m
Deal found 11/11![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:13 am -
2 stops33h 16m
Wed 12/168:09 pm -
1 stop21h 50m
Deal found 11/9![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:00 pm -
1 stop28h 01m
Wed 12/28:09 pm -
1 stop18h 51m
Deal found 11/10![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:55 pm -
2 stops19h 19m
Wed 12/162:57 pm -
1 stop27h 02m
Deal found 11/10![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:59 am -
1 stop9h 30m
Tue 1/51:21 pm -
2 stops33h 24m
Deal found 11/11![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:10 am -
1 stop9h 03m
Mon 12/78:58 pm -
2 stops18h 32m
Deal found 11/10![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:00 pm -
1 stop28h 01m
Tue 12/11:21 pm -
2 stops25h 39m
Deal found 11/10![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:59 am -
1 stop11h 46m
Tue 1/51:21 pm -
2 stops33h 24m
Deal found 11/7![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:45 pm -
2 stops15h 47m
Wed 12/233:13 pm -
1 stop26h 46m
Deal found 11/8![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:35 pm -
1 stop11h 03m
Tue 1/51:21 pm -
2 stops28h 25m
Deal found 11/7![Multiple Airlines logo]()
$324
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:55 pm -
Nonstop2h 04m
Sun 12/66:30 am -
Nonstop2h 16m
Deal found 11/8![United Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:33 pm -
2 stops19h 05m
Wed 12/23:42 pm -
1 stop23h 59m
Deal found 11/11![Multiple Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:50 pm -
1 stop4h 35m
Sat 12/197:10 pm -
Nonstop2h 15m
Deal found 11/9![Southwest logo]()
$359
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:30 am -
1 stop7h 03m
Thu 12/172:18 pm -
1 stop5h 51m
Deal found 11/10![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:45 pm -
1 stop5h 10m
Sat 12/126:24 am -
1 stop5h 41m
Deal found 11/7![American Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/228:52 am -
1 stop4h 23m
Tue 12/225:29 pm -
Nonstop2h 36m
Deal found 11/8![United Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/158:04 am -
1 stop4h 29m
Tue 12/156:59 pm -
1 stop5h 57m
Deal found 11/10![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:00 am -
1 stop5h 10m
Thu 12/108:05 am -
1 stop7h 35m
Deal found 11/11![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:49 am -
1 stop5h 44m
Mon 12/76:57 pm -
1 stop5h 59m
Deal found 11/7![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop8h 21m
Fri 12/2512:00 pm -
1 stop7h 36m
Deal found 11/11![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2010:40 am -
1 stop6h 35m
Sun 1/2411:10 am -
2 stops8h 15m
Deal found 11/9![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:28 am -
1 stop5h 52m
Sat 12/57:00 am -
1 stop4h 28m
Deal found 11/11![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/227:04 am -
1 stop6h 11m
Tue 1/57:42 pm -
1 stop5h 02m
Deal found 11/8![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:45 pm -
1 stop4h 25m
Mon 12/1411:20 am -
2 stops8h 05m
Deal found 11/10![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
1 stop4h 13m
Mon 12/1412:18 pm -
1 stop4h 58m
Deal found 11/10![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:15 pm -
Nonstop2h 10m
Wed 12/304:55 pm -
2 stops7h 45m
Deal found 11/8![Southwest logo]()
$374
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:38 am -
Nonstop2h 22m
Tue 12/812:15 pm -
Nonstop2h 42m
Deal found 11/9![United Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/168:10 am -
1 stop6h 02m
Sat 12/192:35 pm -
1 stop6h 24m
Deal found 11/10![American Airlines logo]()
$521
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:02 pm -
1 stop5h 55m
Mon 12/77:00 am -
1 stop7h 01m
Deal found 11/11![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/810:00 am -
2 stops8h 40m
Mon 1/118:25 am -
2 stops7h 25m
Deal found 11/9![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:55 pm -
Nonstop2h 03m
Thu 11/266:20 am -
Nonstop2h 16m
Deal found 11/7![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop4h 13m
Sat 12/127:00 am -
1 stop7h 01m
Deal found 11/11![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/158:10 am -
1 stop6h 43m
Sun 1/1712:30 pm -
2 stops6h 59m
Deal found 11/8![American Airlines logo]()
$551
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:00 am -
2 stops7h 10m
Thu 12/102:50 pm -
2 stops5h 55m
Deal found 11/8![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2011:20 am -
1 stop4h 05m
Sat 1/235:20 am -
1 stop5h 50m
Deal found 11/9![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:59 pm -
Nonstop2h 22m
Wed 12/210:22 am -
Nonstop2h 38m
Deal found 11/11![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/179:00 am -
1 stop4h 10m
Mon 12/212:35 pm -
1 stop6h 24m
Deal found 11/10![American Airlines logo]()
$551
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/128:00 am -
2 stops8h 20m
Sat 12/197:10 pm -
Nonstop2h 15m
Deal found 11/11![Southwest logo]()
$384
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/215:03 pm -
1 stop5h 48m
Sat 1/237:01 am -
1 stop4h 09m
Deal found 11/9![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:30 am -
Nonstop2h 33m
Thu 12/176:32 pm -
Nonstop2h 40m
Deal found 11/10![United Airlines logo]()
$409
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated November 12, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated November 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:00 pm -
1 stop28h 01m
Wed 12/28:09 pm -
1 stop18h 51m
Deal found 11/10![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:00 pm -
1 stop28h 01m
Tue 12/11:21 pm -
2 stops25h 39m
Deal found 11/10![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:15 am -
2 stops23h 23m
Wed 12/28:09 pm -
1 stop18h 51m
Deal found 11/11![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:13 am -
2 stops33h 16m
Wed 12/168:09 pm -
1 stop21h 50m
Deal found 11/9![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:55 pm -
2 stops19h 19m
Wed 12/162:57 pm -
1 stop27h 02m
Deal found 11/10![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:10 am -
1 stop9h 03m
Mon 12/78:58 pm -
2 stops18h 32m
Deal found 11/10![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
1 stop26h 48m
Mon 12/146:12 pm -
2 stops28h 48m
Deal found 11/8![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
1 stop13h 54m
Mon 12/148:58 pm -
2 stops26h 02m
Deal found 11/9![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:45 pm -
2 stops15h 47m
Wed 12/233:13 pm -
1 stop26h 46m
Deal found 11/8![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:59 am -
1 stop11h 46m
Tue 1/51:21 pm -
2 stops33h 24m
Deal found 11/7![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:35 pm -
1 stop11h 03m
Tue 1/51:21 pm -
2 stops28h 25m
Deal found 11/7![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:59 am -
1 stop9h 30m
Tue 1/51:21 pm -
2 stops33h 24m
Deal found 11/11![Multiple Airlines logo]()
$310
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
1 stop26h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:00 pm -
2 stops15h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
2 stops32h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:00 pm -
2 stops21h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/164:00 pm -
2 stops16h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/66:00 am -
2 stops14h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/7![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:07 am -
2 stops29h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:07 am -
1 stop25h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/812:28 pm -
2 stops24h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:30 am -
2 stops24h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/61:18 pm -
2 stops17h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/7![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:32 pm -
2 stops14h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$141
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated November 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (Kiwi.com) |
One-way from | $122 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $461 |
Good round-trip deal | $278 or less |
Good one-way deal | $185 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 12, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Tue 12/1
9:13 am-9:28 am
2 stops23h 15m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$151
ChicagoMyrtle Beach
MDW Chicago Midway - MYR Myrtle Beach Intl
MDWMYR
Chicago Midway
Thu 12/10
5:02 pm-11:44 am
2 stops17h 42m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$152
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Sat 2/6
10:25 am-1:46 pm
Nonstop2h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Wed 12/30
8:58 pm-12:20 am
Nonstop2h 22m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
Quickest round-trip
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Wed 12/30
7:15 pm-10:25 pm
Nonstop2h 10m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Tue 12/8
5:59 pm-9:21 pm
Nonstop2h 22m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Thu 12/17
5:58 am-1:50 pm
2 stops30h 52m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$184
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Tue 12/1
3:59 pm-10:47 pm
1 stop5h 48m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$185
ChicagoGreenville
MDW Chicago Midway - GSP Greenville
MDWGSP
Chicago Midway
Wed 12/2
12:50 pm-7:55 pm
1 stop6h 05m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$185
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Wed 12/16
8:04 am-1:33 pm
1 stop4h 29m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$185
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
ORD-MYR
ORD-CHS
MDW-CHS
MDW-MYR
MDW-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
ORD-MYR
ORD-CHS
MDW-CHS
MDW-MYR
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $362). Flying from Chicago to South Carolina in March is currently the most expensive (average of $421). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2026.
It’s typically best to fly out from Chicago to South Carolina in the afternoon. Doing so could potentially save you 16% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 12, 2026.
The most flights from CHI to USSC are scheduled on a Wednesday (23 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (15 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
Airfare is below average for this route at the moment.
Chicago to South Carolina flights typically cost between $349 and $496 in January.The cheapest round-trip price found within the last 5 days was $274 on Multiple Airlines (Jan 4-Jan 20).
How far ahead should I book a flight from Chicago to South Carolina?
The price you pay for your flight from Chicago to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 21 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on November 7, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 12, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on November 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 4 airlines flying from Chicago to South Carolina
Discover the top 4 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$152 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$209 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$209 | Average$394 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$244 | Average$421 | FlexibilityNo cancel fee | On-time63% |