$92+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Sep 6 — Sep 131
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:10 pm -
Nonstop2h 24m
Sun 9/66:30 am -
Nonstop2h 30m
Deal found 8/6![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:05 pm -
Nonstop2h 10m
Sun 9/68:40 am -
Nonstop2h 05m
Deal found 8/4![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:50 pm -
Nonstop2h 24m
Sun 9/612:23 pm -
Nonstop2h 36m
Deal found 8/2![American Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:11 am -
1 stop12h 45m
Wed 9/166:00 am -
2 stops13h 23m
Deal found 8/4![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:50 pm -
1 stop15h 48m
Mon 10/54:57 pm -
1 stop23h 23m
Deal found 8/6![Multiple Airlines logo]()
$242
This Mytrip deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:10 pm -
1 stop14h 12m
Sun 10/410:07 am -
1 stop8h 11m
Deal found 8/2![Avelo Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:11 am -
1 stop12h 45m
Mon 10/54:57 pm -
1 stop23h 23m
Deal found 8/3![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:05 am -
1 stop9h 09m
Thu 9/104:43 pm -
1 stop23h 02m
Deal found 8/2![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:11 am -
1 stop8h 04m
Thu 9/179:15 am -
2 stops16h 30m
Deal found 8/5![Multiple Airlines logo]()
$246
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:55 am -
Nonstop2h 15m
Sun 9/65:05 pm -
1 stop6h 30m
Deal found 8/5![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:10 am -
Nonstop2h 30m
Sun 9/69:50 am -
1 stop8h 02m
Deal found 8/5![United Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:30 am -
1 stop5h 46m
Sun 9/611:53 am -
Nonstop2h 36m
Deal found 8/3![American Airlines logo]()
$248
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:10 am -
Nonstop2h 30m
Sat 9/123:55 pm -
Nonstop2h 34m
Deal found 8/5![United Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:30 am -
1 stop5h 05m
Fri 9/117:00 am -
Nonstop2h 10m
Deal found 8/5![Southwest logo]()
$268
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:24 am -
1 stop5h 43m
Sun 9/61:17 pm -
1 stop4h 42m
Deal found 8/2![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:17 pm -
1 stop4h 32m
Sat 9/1910:23 am -
1 stop5h 42m
Deal found 8/1![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:05 am -
1 stop26h 00m
Sun 8/232:58 pm -
1 stop9h 10m
Deal found 8/1![Multiple Airlines logo]()
$383
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:20 pm -
Nonstop1h 55m
Tue 9/86:30 pm -
Nonstop2h 00m
Deal found 8/5![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:17 pm -
Nonstop2h 00m
Tue 10/136:20 am -
Nonstop2h 09m
Deal found 8/6![United Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:24 am -
1 stop5h 43m
Sun 9/611:50 am -
1 stop4h 54m
Deal found 8/6![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:55 am -
Nonstop2h 03m
Tue 10/136:20 am -
Nonstop2h 09m
Deal found 8/6![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:15 pm -
Nonstop2h 15m
Thu 9/246:30 pm -
Nonstop2h 10m
Deal found 8/6![Southwest logo]()
$279
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/510:56 am -
1 stop3h 52m
Sat 9/1212:00 pm -
1 stop4h 24m
Deal found 8/6![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2110:53 am -
1 stop4h 42m
Sun 8/236:34 pm -
Nonstop2h 30m
Deal found 8/6![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:17 pm -
Nonstop2h 00m
Wed 10/142:16 pm -
Nonstop2h 17m
Deal found 8/5![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 pm -
Nonstop2h 15m
Wed 9/237:35 am -
Nonstop2h 10m
Deal found 8/2![Southwest logo]()
$279
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 pm -
1 stop5h 49m
Sat 10/36:00 am -
1 stop4h 25m
Deal found 8/4![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:03 pm -
Nonstop2h 12m
Tue 10/66:45 am -
Nonstop2h 15m
Deal found 8/5![United Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:45 am -
Nonstop2h 10m
Thu 9/311:50 am -
1 stop4h 40m
Deal found 8/4![Southwest logo]()
$293
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:51 pm -
1 stop3h 43m
Wed 10/75:59 pm -
1 stop6h 53m
Deal found 8/6![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:45 pm -
Nonstop2h 10m
Thu 12/318:14 am -
Nonstop2h 22m
Deal found 8/6![United Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:25 pm -
Nonstop1h 55m
Thu 12/101:30 pm -
1 stop6h 25m
Deal found 8/6![Southwest logo]()
$293
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:30 am -
1 stop6h 44m
Wed 9/235:59 pm -
1 stop7h 00m
Deal found 8/2![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:55 pm -
Nonstop2h 39m
Tue 10/1312:46 pm -
Nonstop2h 35m
Deal found 8/6![United Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 am -
2 stops7h 40m
Tue 11/108:00 am -
Nonstop2h 15m
Deal found 8/5![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop5h 44m
Mon 11/91:59 pm -
1 stop6h 03m
Deal found 8/4![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:55 pm -
Nonstop2h 23m
Tue 9/2910:25 am -
1 stop5h 01m
Deal found 8/4![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:35 pm -
Nonstop2h 00m
Mon 8/313:20 pm -
1 stop3h 55m
Deal found 8/4![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:04 am -
1 stop4h 11m
Mon 12/215:40 am -
1 stop3h 54m
Deal found 8/3![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:03 pm -
Nonstop2h 12m
Sat 9/266:00 am -
1 stop4h 38m
Deal found 8/4![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:55 am -
1 stop4h 15m
Sun 9/65:35 pm -
1 stop6h 10m
Deal found 8/4![Southwest logo]()
$298
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:55 pm -
1 stop6h 31m
Wed 9/237:15 am -
1 stop6h 44m
Deal found 8/2![Delta logo]()
$299
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated August 7, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated August 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:05 am -
1 stop9h 09m
Thu 9/104:43 pm -
1 stop23h 02m
Deal found 8/2![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:59 pm -
2 stops22h 56m
Wed 9/912:23 pm -
1 stop27h 22m
Deal found 8/5![Multiple Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:10 pm -
Nonstop2h 24m
Sun 9/66:30 am -
Nonstop2h 30m
Deal found 8/6![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:05 pm -
Nonstop2h 10m
Sun 9/68:40 am -
Nonstop2h 05m
Deal found 8/4![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:50 pm -
Nonstop2h 24m
Sun 9/612:23 pm -
Nonstop2h 36m
Deal found 8/2![American Airlines logo]()
$238
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:55 am -
Nonstop2h 15m
Sun 9/65:05 pm -
1 stop6h 30m
Deal found 8/5![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:10 am -
Nonstop2h 30m
Sun 9/69:50 am -
1 stop8h 02m
Deal found 8/5![United Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:30 am -
1 stop5h 46m
Sun 9/611:53 am -
Nonstop2h 36m
Deal found 8/3![American Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:11 am -
1 stop12h 45m
Wed 9/166:00 am -
2 stops13h 23m
Deal found 8/4![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:11 am -
1 stop8h 04m
Thu 9/179:15 am -
2 stops16h 30m
Deal found 8/5![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:50 pm -
1 stop15h 48m
Mon 10/54:57 pm -
1 stop23h 23m
Deal found 8/6![Multiple Airlines logo]()
$242
This Mytrip deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:10 pm -
1 stop14h 12m
Sun 10/410:07 am -
1 stop8h 11m
Deal found 8/2![Avelo Airlines logo]()
$242
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:11 am -
1 stop8h 04m
Deal found 8/6![Multiple Airlines logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:11 am -
2 stops25h 16m
Deal found 8/5![Multiple Airlines logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:11 am -
1 stop28h 28m
Deal found 8/6![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:11 am -
1 stop9h 03m
Deal found 8/6![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:11 am -
1 stop9h 03m
Deal found 8/6![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:55 am -
1 stop5h 39m
Deal found 8/3![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:11 am -
2 stops9h 12m
Deal found 8/3![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:11 am -
1 stop8h 04m
Deal found 8/2![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:05 am -
1 stop8h 50m
Deal found 8/3![Multiple Airlines logo]()
$106
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:25 pm -
1 stop5h 24m
Deal found 8/3![Delta logo]()
$109
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:39 pm -
1 stop4h 10m
Deal found 8/4![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:05 am -
1 stop22h 52m
Deal found 8/4![Multiple Airlines logo]()
$110
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated August 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (United Airlines) |
One-way from | $92 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $325 |
Good round-trip deal | $277 or less |
Good one-way deal | $98 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSavannah
ORD Chicago O'Hare Intl - SAV Savannah/Hilton Head
ORDSAV
Chicago O'Hare Intl
Sat 9/5
7:10 am-10:40 am
Nonstop2h 30m
Savannah/Hilton Head
Sat 9/12
3:55 pm-5:29 pm
Nonstop2h 34m
$263
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Wed 9/9
6:30 am-12:35 pm
1 stop5h 05m
Charleston
Fri 9/11
7:00 am-8:10 am
Nonstop2h 10m
$268
Quickest round-trip
ChicagoCharlotte
MDW Chicago Midway - CLT Charlotte Douglas
MDWCLT
Chicago Midway
Sun 9/6
2:20 pm-5:15 pm
Nonstop1h 55m
Charlotte Douglas
Tue 9/8
6:30 pm-7:30 pm
Nonstop2h 00m
$271
ChicagoCharlotte
MDW Chicago Midway - CLT Charlotte Douglas
MDWCLT
Chicago Midway
Sat 9/5
9:24 am-4:07 pm
1 stop5h 43m
Charlotte Douglas
Sun 9/6
1:17 pm-4:59 pm
1 stop4h 42m
$279
ChicagoGreenville
ORD Chicago O'Hare Intl - GSP Greenville
ORDGSP
Chicago O'Hare Intl
Fri 10/9
6:17 pm-9:17 pm
Nonstop2h 00m
Greenville
Tue 10/13
6:20 am-7:29 am
Nonstop2h 09m
$279
ChicagoGreenville
ORD Chicago O'Hare Intl - GSP Greenville
ORDGSP
Chicago O'Hare Intl
Wed 10/7
6:55 am-9:58 am
Nonstop2h 03m
Greenville
Tue 10/13
6:20 am-7:29 am
Nonstop2h 09m
$279
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Mon 9/21
6:15 pm-9:30 pm
Nonstop2h 15m
Charleston
Thu 9/24
6:30 pm-7:40 pm
Nonstop2h 10m
$279
ChicagoGreenville
ORD Chicago O'Hare Intl - GSP Greenville
ORDGSP
Chicago O'Hare Intl
Fri 10/9
6:17 pm-9:17 pm
Nonstop2h 00m
Greenville
Wed 10/14
2:16 pm-3:33 pm
Nonstop2h 17m
$279
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Wed 9/16
6:00 pm-9:15 pm
Nonstop2h 15m
Charleston
Wed 9/23
7:35 am-8:45 am
Nonstop2h 10m
$279
ChicagoCharlotte
ORD Chicago O'Hare Intl - CLT Charlotte Douglas
ORDCLT
Chicago O'Hare Intl
Thu 10/1
6:03 pm-9:15 pm
Nonstop2h 12m
Charlotte Douglas
Tue 10/6
6:45 am-8:00 am
Nonstop2h 15m
$283
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
ORD-CHS
MDW-CHS
ORD-SAV
MDW-SAV
MDW-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
ORD-CHS
MDW-CHS
ORD-SAV
MDW-SAV
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $332). Flying from Chicago to South Carolina in March is currently the most expensive (average of $418). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 7, 2026.
It’s typically best to fly out from Chicago to South Carolina in the afternoon. Doing so could potentially save you 14% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 7, 2026.
The most flights from CHI to USSC are scheduled on a Thursday (21 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
Airfare is below average for this route at the moment.
Chicago to South Carolina flights typically cost between $291 and $457 in September.The cheapest round-trip price found within the last 5 days was $237 on United Airlines (Sep 5-Sep 6).
How far ahead should I book a flight from Chicago to South Carolina?
The price you pay for your flight from Chicago to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on August 1, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 7, 2026.
See what other customers who have flown with Southwest,United Airlines, andAmerican Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Overall
8.0
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on August 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 4 airlines flying from Chicago to South Carolina
Discover the top 4 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$334 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$202 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$209 | Average$387 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$222 | Average$410 | FlexibilityNo cancel fee | On-time63% |