$99+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Aug 16 — Aug 231
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- GSP
1 stop22h 52m
Multiple Airlines
Mon 8/248:13 pm
GSP
- ORD
2 stops17h 37m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:05 am
ORD
- GSP
2 stops10h 28m
Multiple Airlines
Mon 8/3112:06 pm
GSP
- ORD
1 stop25h 44m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:05 am
ORD
- GSP
1 stop7h 02m
Multiple Airlines
Mon 8/174:57 pm
GSP
- ORD
1 stop20h 53m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:37 pm
ORD
- CHS
Nonstop2h 22m
American Airlines
Wed 8/267:50 pm
CHS
- ORD
Nonstop2h 44m
American Airlines
Deal found 7/13![American Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:05 am
ORD
- GSP
2 stops10h 34m
Multiple Airlines
Mon 8/2412:06 pm
GSP
- ORD
1 stop25h 44m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:40 pm
ORD
- CHS
Nonstop2h 19m
American Airlines
Thu 11/57:47 pm
CHS
- ORD
1 stop4h 49m
American Airlines
Deal found 7/15![American Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:00 am
MDW
- CHS
1 stop5h 25m
Southwest
Tue 8/117:35 am
CHS
- MDW
Nonstop2h 10m
Southwest
Deal found 7/14![Southwest logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:50 am
ORD
- SAV
1 stop12h 09m
Multiple Airlines
Sun 11/85:14 pm
SAV
- ORD
1 stop23h 10m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:45 am
ORD
- CHS
1 stop7h 18m
Multiple Airlines
Sun 9/208:46 pm
CHS
- ORD
1 stop19h 40m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:45 am
ORD
- CHS
2 stops27h 46m
Multiple Airlines
Thu 9/172:13 pm
CHS
- ORD
1 stop10h 42m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- SAV
1 stop8h 50m
Multiple Airlines
Sun 8/237:15 am
SAV
- ORD
2 stops13h 44m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:49 pm
ORD
- CHS
1 stop14h 49m
Multiple Airlines
Tue 10/203:18 pm
CHS
- ORD
1 stop22h 58m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$251
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:15 pm
MDW
- CHS
Nonstop2h 10m
Southwest
Mon 8/105:20 pm
CHS
- MDW
1 stop5h 35m
Southwest
Deal found 7/16![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:50 pm
ORD
- CHS
1 stop5h 54m
Delta
Mon 8/315:06 pm
CHS
- ORD
1 stop4h 49m
Delta
Deal found 7/13![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:30 am
ORD
- SAV
Nonstop2h 30m
United Airlines
Sat 10/172:10 pm
SAV
- ORD
1 stop5h 31m
United Airlines
Deal found 7/12![United Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:15 pm
MDW
- CHS
Nonstop2h 10m
Southwest
Thu 8/206:35 am
CHS
- MDW
2 stops6h 40m
Southwest
Deal found 7/16![Southwest logo]()
$252
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:40 am
ORD
- CHS
1 stop6h 12m
Delta
Thu 8/2012:59 pm
CHS
- ORD
1 stop6h 30m
Delta
Deal found 7/15![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:30 am
ORD
- GSP
Nonstop2h 06m
United Airlines
Mon 8/242:18 pm
GSP
- ORD
Nonstop2h 12m
United Airlines
Deal found 7/15![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:05 am
MDW
- SAV
1 stop6h 59m
Delta
Mon 8/316:35 am
SAV
- MDW
1 stop4h 24m
Delta
Deal found 7/15![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:45 am
MDW
- CHS
1 stop8h 10m
Southwest
Wed 8/268:10 am
CHS
- MDW
2 stops9h 25m
Southwest
Deal found 7/13![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:55 pm
ORD
- GSP
Nonstop2h 07m
United Airlines
Tue 8/182:18 pm
GSP
- ORD
Nonstop2h 12m
United Airlines
Deal found 7/15![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:19 am
ORD
- SAV
1 stop5h 33m
Delta
Tue 11/312:43 pm
SAV
- ORD
1 stop7h 16m
Delta
Deal found 7/15![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:45 am
MDW
- CHS
2 stops6h 35m
Southwest
Tue 9/2210:45 am
CHS
- MDW
1 stop5h 35m
Southwest
Deal found 7/15![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:55 pm
ORD
- GSP
Nonstop2h 07m
United Airlines
Mon 8/175:43 pm
GSP
- ORD
Nonstop2h 20m
United Airlines
Deal found 7/13![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:05 am
ORD
- SAV
1 stop6h 49m
Delta
Sat 9/192:55 pm
SAV
- ORD
1 stop7h 00m
Delta
Deal found 7/15![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:45 am
MDW
- SAV
1 stop8h 10m
Southwest
Mon 8/171:05 pm
SAV
- MDW
2 stops7h 20m
Southwest
Deal found 7/16![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:30 am
ORD
- CLT
1 stop6h 48m
United Airlines
Mon 8/173:35 pm
CLT
- ORD
Nonstop2h 23m
United Airlines
Deal found 7/16![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:22 am
ORD
- SAV
1 stop5h 08m
Delta
Tue 8/185:35 am
SAV
- ORD
1 stop4h 48m
Delta
Deal found 7/13![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:55 am
MDW
- SAV
2 stops8h 45m
Southwest
Mon 8/311:05 pm
SAV
- MDW
2 stops7h 20m
Southwest
Deal found 7/15![Southwest logo]()
$267
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:50 am
ORD
- CLT
Nonstop2h 18m
United Airlines
Tue 8/1810:25 am
CLT
- ORD
1 stop5h 05m
United Airlines
Deal found 7/13![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:55 pm
ORD
- SAV
1 stop5h 04m
Delta
Mon 11/165:35 pm
SAV
- ORD
1 stop4h 35m
Delta
Deal found 7/14![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:10 am
MDW
- SAV
2 stops8h 05m
Southwest
Wed 8/198:00 am
SAV
- MDW
2 stops8h 25m
Southwest
Deal found 7/13![Southwest logo]()
$267
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:45 am
ORD
- CAE
1 stop4h 36m
United Airlines
Sun 8/306:25 am
CAE
- ORD
Nonstop2h 30m
United Airlines
Deal found 7/17![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:05 am
MDW
- MYR
2 stops8h 35m
Southwest
Tue 9/158:15 am
MYR
- MDW
2 stops5h 50m
Southwest
Deal found 7/16![Southwest logo]()
$268
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:54 am
MDW
- CLT
1 stop6h 48m
Delta
Wed 8/198:10 am
CLT
- MDW
1 stop4h 41m
Delta
Deal found 7/12![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:50 am
ORD
- CAE
1 stop4h 36m
United Airlines
Wed 10/77:46 pm
CAE
- ORD
1 stop4h 46m
United Airlines
Deal found 7/12![United Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:45 pm
MDW
- CLT
1 stop5h 15m
Southwest
Wed 8/196:35 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 7/16![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:25 pm
ORD
- CLT
1 stop4h 34m
Delta
Mon 9/145:30 am
CLT
- ORD
1 stop4h 05m
Delta
Deal found 7/12![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:40 am
MDW
- CLT
1 stop4h 05m
Southwest
Tue 8/116:35 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 7/15![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:59 am
ORD
- CLT
1 stop4h 18m
Delta
Tue 8/115:04 pm
CLT
- ORD
1 stop4h 26m
Delta
Deal found 7/15![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:50 am
ORD
- CHS
1 stop5h 10m
United Airlines
Mon 10/197:53 pm
CHS
- ORD
1 stop4h 39m
United Airlines
Deal found 7/15![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 pm
MDW
- CHS
Nonstop2h 10m
Southwest
Tue 9/227:35 am
CHS
- MDW
Nonstop2h 10m
Southwest
Deal found 7/17![Southwest logo]()
$269
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated July 17, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated July 17, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:00 am
MDW
- CHS
1 stop5h 25m
Southwest
Tue 8/117:35 am
CHS
- MDW
Nonstop2h 10m
Southwest
Deal found 7/14![Southwest logo]()
$247
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:20 pm
MDW
- SAV
1 stop5h 35m
Southwest
Mon 8/105:35 pm
SAV
- MDW
1 stop4h 25m
Southwest
Deal found 7/16![Southwest logo]()
$252
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:49 am
ORD
- CHS
1 stop5h 27m
American Airlines
Sat 8/1512:21 pm
CHS
- ORD
Nonstop2h 36m
American Airlines
Deal found 7/13![American Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:05 am
ORD
- GSP
1 stop7h 02m
Multiple Airlines
Mon 8/174:57 pm
GSP
- ORD
1 stop20h 53m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- CHS
1 stop14h 09m
Multiple Airlines
Sat 8/228:56 pm
CHS
- ORD
2 stops24h 03m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- GSP
1 stop22h 52m
Multiple Airlines
Mon 8/248:13 pm
GSP
- ORD
2 stops17h 37m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- SAV
1 stop8h 50m
Multiple Airlines
Sun 8/237:15 am
SAV
- ORD
2 stops13h 44m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:05 am
ORD
- GSP
2 stops10h 34m
Multiple Airlines
Mon 8/2412:06 pm
GSP
- ORD
1 stop25h 44m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:37 pm
ORD
- CHS
Nonstop2h 22m
American Airlines
Wed 8/267:50 pm
CHS
- ORD
Nonstop2h 44m
American Airlines
Deal found 7/13![American Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:05 am
ORD
- GSP
2 stops10h 28m
Multiple Airlines
Mon 8/3112:06 pm
GSP
- ORD
1 stop25h 44m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$195
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:00 am
ORD
- CHS
1 stop4h 28m
American Airlines
Thu 8/2712:23 pm
CHS
- ORD
Nonstop2h 36m
American Airlines
Deal found 7/15![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:05 pm
MDW
- CHS
Nonstop2h 05m
Southwest
Mon 8/318:40 am
CHS
- MDW
2 stops7h 15m
Southwest
Deal found 7/14![Southwest logo]()
$252
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:15 am
ORD
- MYR
Nonstop2h 19m
American Airlines
Deal found 7/13![American Airlines logo]()
$99
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:35 pm
MDW
- MYR
Nonstop2h 00m
Southwest
Deal found 7/14![Southwest logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:05 am
ORD
- GSP
1 stop7h 39m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- SAV
1 stop8h 50m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:05 am
ORD
- GSP
1 stop31h 02m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:45 am
ORD
- SAV
1 stop12h 14m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:45 am
ORD
- SAV
1 stop12h 14m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:45 am
ORD
- GSP
1 stop23h 26m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- CHS
1 stop27h 59m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$108
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
ORD
- MYR
1 stop4h 17m
Delta
Deal found 7/13![Delta logo]()
$109
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:54 am
MDW
- MYR
1 stop6h 13m
Delta
Deal found 7/13![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:05 am
ORD
- CHS
1 stop9h 09m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$112
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated July 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $193 (Kiwi.com) |
One-way from | $99 (American Airlines) |
Popular in | December |
Cheapest in | August |
Average price | $405 |
Good round-trip deal | $274 or less |
Good one-way deal | $98 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoCharleston
MDW - CHS
MDWCHS
Chicago Midway
Thu 8/6
6:15 pm-9:25 pm
Nonstop2h 10m
Charleston
Mon 8/10
5:20 pm-9:55 pm
1 stop5h 35m
$247
ChicagoCharleston
MDW - CHS
MDWCHS
Chicago Midway
Thu 8/13
6:15 pm-9:25 pm
Nonstop2h 10m
Charleston
Thu 8/20
6:35 am-12:15 pm
2 stops6h 40m
$252
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Thu 8/27
1:50 pm-8:44 pm
1 stop5h 54m
Charleston
Mon 8/31
5:06 pm-8:55 pm
1 stop4h 49m
$257
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Sat 8/15
6:40 am-1:52 pm
1 stop6h 12m
Charleston
Thu 8/20
12:59 pm-6:29 pm
1 stop6h 30m
$257
ChicagoSavannah
MDW - SAV
MDWSAV
Chicago Midway
Thu 8/27
6:05 am-2:04 pm
1 stop6h 59m
Savannah/Hilton Head
Mon 8/31
6:35 am-9:59 am
1 stop4h 24m
$257
ChicagoSavannah
ORD - SAV
ORDSAV
Chicago O'Hare Intl
Tue 10/27
11:19 am-5:52 pm
1 stop5h 33m
Savannah/Hilton Head
Tue 11/3
12:43 pm-6:59 pm
1 stop7h 16m
$257
ChicagoSavannah
ORD - SAV
ORDSAV
Chicago O'Hare Intl
Sat 9/12
8:05 am-3:54 pm
1 stop6h 49m
Savannah/Hilton Head
Sat 9/19
2:55 pm-8:55 pm
1 stop7h 00m
$257
ChicagoSavannah
ORD - SAV
ORDSAV
Chicago O'Hare Intl
Thu 8/13
11:22 am-5:30 pm
1 stop5h 08m
Savannah/Hilton Head
Tue 8/18
5:35 am-9:23 am
1 stop4h 48m
$257
ChicagoSavannah
ORD - SAV
ORDSAV
Chicago O'Hare Intl
Thu 11/12
5:55 pm-11:59 pm
1 stop5h 04m
Savannah/Hilton Head
Mon 11/16
5:35 pm-9:10 pm
1 stop4h 35m
$257
ChicagoCharleston
MDW - CHS
MDWCHS
Chicago Midway
Sat 8/22
6:45 am-3:55 pm
1 stop8h 10m
Charleston
Wed 8/26
8:10 am-4:35 pm
2 stops9h 25m
$262
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
ORD-GSP
ORD-CHS
MDW-CHS
ORD-SAV
MDW-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
ORD-GSP
ORD-CHS
MDW-CHS
ORD-SAV
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $334). Flying from Chicago to South Carolina in March is currently the most expensive (average of $418). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 17, 2026.
It’s typically best to fly out from Chicago to South Carolina in the afternoon. Doing so could potentially save you 13% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 17, 2026.
The most flights from CHI to USSC are scheduled on a Thursday (21 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (14 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
How far ahead should I book a flight from Chicago to South Carolina?
The price you pay for your flight from Chicago to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on July 11, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 17, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentSarah,Aug 2024
MDW - AUS
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on July 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 4 airlines flying from Chicago to South Carolina
Discover the top 4 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$146 | Average$290 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$153 | Average$408 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$202 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$209 | Average$381 | FlexibilityNo cancel fee | On-time69% |