$99+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:15 am
ORD
- MYR
Nonstop2h 19m
American Airlines
Mon 8/175:15 pm
MYR
- ORD
1 stop5h 42m
American Airlines
Deal found 6/13![American Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:25 pm
ORD
- MYR
1 stop7h 05m
Delta
Mon 8/172:18 pm
MYR
- ORD
1 stop5h 31m
Delta
Deal found 6/10![Delta logo]()
$256
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:30 am
ORD
- MYR
1 stop4h 17m
Delta
Mon 8/1011:33 am
MYR
- ORD
1 stop5h 44m
Delta
Deal found 6/15![Delta logo]()
$258
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:15 am
ORD
- MYR
Nonstop2h 19m
American Airlines
Sat 8/295:00 pm
MYR
- ORD
Nonstop2h 38m
American Airlines
Deal found 6/11![American Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:40 pm
MDW
- CLT
1 stop3h 40m
Southwest
Tue 8/46:35 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 6/11![Southwest logo]()
$259
This Gotogate deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:20 am
ORD
- CLT
1 stop4h 40m
Contour
Mon 7/136:05 pm
CLT
- ORD
1 stop25h 00m
Contour
Deal found 6/14![Contour logo]()
$259
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:50 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Tue 11/106:45 am
CLT
- MDW
2 stops8h 40m
Southwest
Deal found 6/11![Southwest logo]()
$260
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
ORD
- CLT
1 stop22h 37m
Frontier
Wed 7/85:57 pm
CLT
- ORD
1 stop7h 52m
Frontier
Deal found 6/10![Frontier logo]()
$260
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:15 am
ORD
- MYR
Nonstop2h 33m
United Airlines
Tue 8/1110:23 am
MYR
- ORD
1 stop5h 07m
United Airlines
Deal found 6/11![United Airlines logo]()
$262
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:10 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Fri 11/278:10 am
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Mon 8/176:30 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$263
This Frontier deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:52 pm
ORD
- CLT
1 stop12h 04m
Frontier
Mon 7/135:57 pm
CLT
- ORD
1 stop7h 52m
Frontier
Deal found 6/11![Frontier logo]()
$263
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:25 pm
ORD
- MYR
1 stop7h 05m
Delta
Mon 8/172:18 pm
MYR
- ORD
1 stop5h 31m
Delta
Deal found 6/10![Delta logo]()
$256
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2111:00 am
ORD
- MYR
Nonstop2h 19m
United Airlines
Tue 7/283:15 pm
MYR
- ORD
Nonstop2h 34m
United Airlines
Deal found 6/13![United Airlines logo]()
$266
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:15 am
MDW
- CLT
2 stops9h 00m
Southwest
Tue 11/1011:00 am
CLT
- MDW
2 stops7h 45m
Southwest
Deal found 6/11![Southwest logo]()
$276
This JetBlue deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/319:42 am
ORD
- CHS
1 stop9h 10m
JetBlue
Mon 8/36:40 pm
CHS
- ORD
1 stop6h 04m
JetBlue
Deal found 6/14![JetBlue logo]()
$403
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:55 pm
ORD
- CAE
Nonstop2h 21m
United Airlines
Sun 7/126:25 am
CAE
- ORD
Nonstop2h 27m
United Airlines
Deal found 6/11![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2211:50 am
MDW
- SAV
2 stops7h 50m
Southwest
Tue 7/287:50 am
SAV
- MDW
2 stops7h 15m
Southwest
Deal found 6/14![Southwest logo]()
$277
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 am
ORD
- CAE
1 stop4h 39m
Delta
Sun 8/91:59 pm
CAE
- ORD
1 stop5h 50m
Delta
Deal found 6/10![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:10 am
ORD
- CAE
Nonstop2h 18m
United Airlines
Thu 7/96:25 am
CAE
- ORD
Nonstop2h 27m
United Airlines
Deal found 6/10![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:03 am
ORD
- CAE
1 stop3h 56m
Delta
Sun 7/125:35 am
CAE
- ORD
1 stop4h 00m
Delta
Deal found 6/11![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:40 am
MDW
- CHS
1 stop6h 30m
Southwest
Sat 7/185:30 am
CHS
- MDW
Nonstop2h 10m
Southwest
Deal found 6/14![Southwest logo]()
$289
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:55 pm
ORD
- CAE
Nonstop2h 21m
United Airlines
Mon 8/106:25 am
CAE
- ORD
Nonstop2h 27m
United Airlines
Deal found 6/12![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:30 am
ORD
- CAE
1 stop4h 39m
Delta
Fri 8/146:08 pm
CAE
- ORD
1 stop6h 49m
Delta
Deal found 6/10![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:55 am
MDW
- SAV
1 stop5h 20m
Southwest
Sat 9/197:40 am
SAV
- MDW
Nonstop2h 15m
Southwest
Deal found 6/15![Southwest logo]()
$289
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:17 pm
ORD
- GSP
Nonstop2h 09m
United Airlines
Mon 7/205:43 pm
GSP
- ORD
Nonstop2h 17m
United Airlines
Deal found 6/10![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:40 am
ORD
- CAE
1 stop5h 34m
Delta
Tue 8/113:50 pm
CAE
- ORD
1 stop6h 05m
Delta
Deal found 6/11![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:45 am
MDW
- CLT
2 stops6h 35m
Southwest
Mon 9/147:40 am
CLT
- MDW
1 stop7h 25m
Southwest
Deal found 6/10![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:15 pm
ORD
- CLT
Nonstop2h 14m
United Airlines
Tue 7/216:00 am
CLT
- ORD
1 stop4h 36m
United Airlines
Deal found 6/14![United Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:30 am
ORD
- GSP
1 stop4h 10m
Delta
Sun 8/2311:10 am
GSP
- ORD
1 stop6h 07m
Delta
Deal found 6/14![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:20 pm
MDW
- CHS
Nonstop2h 05m
Southwest
Sat 7/46:30 am
CHS
- MDW
2 stops9h 25m
Southwest
Deal found 6/10![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
ORD
- GSP
1 stop3h 51m
Delta
Sun 8/96:55 am
GSP
- ORD
1 stop4h 18m
Delta
Deal found 6/12![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:30 am
ORD
- CLT
Nonstop2h 14m
United Airlines
Tue 8/1112:50 pm
CLT
- ORD
Nonstop2h 25m
United Airlines
Deal found 6/14![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:55 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Tue 8/111:30 pm
CLT
- MDW
2 stops6h 35m
Southwest
Deal found 6/14![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:35 am
ORD
- GSP
1 stop6h 26m
Delta
Mon 8/37:15 am
GSP
- ORD
1 stop6h 53m
Delta
Deal found 6/10![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:25 pm
ORD
- CHS
Nonstop2h 23m
United Airlines
Tue 7/146:00 am
CHS
- ORD
Nonstop2h 33m
United Airlines
Deal found 6/13![United Airlines logo]()
$297
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:54 am
ORD
- GSP
1 stop5h 21m
Delta
Sun 8/305:46 am
GSP
- ORD
1 stop3h 58m
Delta
Deal found 6/14![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:05 am
MDW
- CLT
Nonstop2h 05m
Southwest
Fri 10/98:50 pm
CLT
- MDW
1 stop4h 05m
Southwest
Deal found 6/12![Southwest logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:00 pm
ORD
- CLT
1 stop6h 59m
United Airlines
Tue 9/156:45 am
CLT
- ORD
Nonstop2h 16m
United Airlines
Deal found 6/10![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:30 am
ORD
- GSP
1 stop5h 44m
Delta
Sun 7/265:44 am
GSP
- ORD
1 stop3h 51m
Delta
Deal found 6/11![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:15 pm
MDW
- CHS
Nonstop2h 10m
Southwest
Sun 8/168:15 am
CHS
- MDW
Nonstop2h 05m
Southwest
Deal found 6/10![Southwest logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:50 am
ORD
- CLT
1 stop7h 06m
United Airlines
Mon 9/146:00 pm
CLT
- ORD
Nonstop2h 29m
United Airlines
Deal found 6/13![United Airlines logo]()
$303
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated June 15, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:48 pm
ORD
- CLT
1 stop22h 37m
Frontier
Wed 7/85:57 pm
CLT
- ORD
1 stop7h 52m
Frontier
Deal found 6/10![Frontier logo]()
$260
This Gotogate deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:20 am
ORD
- CLT
1 stop4h 40m
Contour
Mon 7/136:05 pm
CLT
- ORD
1 stop25h 00m
Contour
Deal found 6/14![Contour logo]()
$259
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:44 am
ORD
- CLT
1 stop17h 49m
Frontier
Sun 7/1210:59 pm
CLT
- ORD
1 stop11h 12m
Frontier
Deal found 6/10![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:05 am
ORD
- CLT
1 stop12h 02m
Frontier
Fri 7/176:41 pm
CLT
- ORD
1 stop18h 34m
Frontier
Deal found 6/12![Frontier logo]()
$265
This Frontier deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:52 pm
ORD
- CLT
1 stop12h 04m
Frontier
Mon 7/135:57 pm
CLT
- ORD
1 stop7h 52m
Frontier
Deal found 6/11![Frontier logo]()
$263
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:00 am
MDW
- CLT
Nonstop2h 10m
Southwest
Wed 7/223:10 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 6/15![Southwest logo]()
$269
This Frontier deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:34 pm
ORD
- CLT
1 stop12h 42m
Frontier
Mon 7/2010:51 am
CLT
- ORD
1 stop10h 02m
Frontier
Deal found 6/10![Frontier logo]()
$268
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:17 pm
ORD
- GSP
Nonstop2h 09m
United Airlines
Mon 7/205:43 pm
GSP
- ORD
Nonstop2h 17m
United Airlines
Deal found 6/10![United Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2111:00 am
ORD
- MYR
Nonstop2h 19m
United Airlines
Tue 7/283:15 pm
MYR
- ORD
Nonstop2h 34m
United Airlines
Deal found 6/15![United Airlines logo]()
$266
This Trip.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:05 am
ORD
- CLT
1 stop12h 02m
Frontier
Wed 7/295:57 pm
CLT
- ORD
1 stop7h 52m
Frontier
Deal found 6/10![Frontier logo]()
$266
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/298:30 pm
ORD
- CAE
Nonstop2h 10m
American Airlines
Sun 8/26:06 am
CAE
- ORD
Nonstop2h 24m
American Airlines
Deal found 6/11![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:40 pm
MDW
- CLT
1 stop3h 40m
Southwest
Tue 8/46:35 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 6/11![Southwest logo]()
$259
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:27 am
ORD
- MYR
Nonstop2h 26m
United Airlines
Deal found 6/12![United Airlines logo]()
$99
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:10 am
MDW
- CLT
2 stops10h 15m
Southwest
Deal found 6/11![Southwest logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:05 am
ORD
- CLT
1 stop12h 02m
Frontier
Deal found 6/14![Frontier logo]()
$102
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:13 am
ORD
- CHS
Nonstop2h 20m
American Airlines
Deal found 6/11![American Airlines logo]()
$103
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 pm
MDW
- CHS
Nonstop2h 10m
Southwest
Deal found 6/11![Southwest logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:05 am
ORD
- CLT
1 stop12h 02m
Frontier
Deal found 6/12![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:26 am
ORD
- CHS
1 stop22h 12m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$105
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/89:25 am
MDW
- CLT
Nonstop1h 55m
Southwest
Deal found 6/11![Southwest logo]()
$105
This Frontier deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:20 am
ORD
- CLT
1 stop8h 22m
Frontier
Deal found 6/13![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:30 pm
ORD
- CHS
1 stop14h 08m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:05 am
ORD
- CLT
1 stop12h 02m
Frontier
Deal found 6/11![Frontier logo]()
$107
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:40 am
MDW
- CLT
2 stops10h 00m
Southwest
Deal found 6/11![Southwest logo]()
$108
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $251 (American Airlines) |
One-way from | $99 (United Airlines) |
Popular in | December |
Cheapest in | September |
Average price | $395 |
Good round-trip deal | $279 or less |
Good one-way deal | $161 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoMyrtle Beach
ORD - MYR
ORDMYR
Chicago O'Hare Intl
Tue 8/11
3:25 pm-11:30 pm
1 stop7h 05m
Myrtle Beach Intl
Mon 8/17
2:18 pm-6:49 pm
1 stop5h 31m
$256
ChicagoMyrtle Beach
ORD - MYR
ORDMYR
Chicago O'Hare Intl
Tue 7/21
11:00 am-2:19 pm
Nonstop2h 19m
Myrtle Beach Intl
Tue 7/28
3:15 pm-4:49 pm
Nonstop2h 34m
$266
ChicagoColumbia
ORD - CAE
ORDCAE
Chicago O'Hare Intl
Thu 7/9
5:55 pm-9:16 pm
Nonstop2h 21m
Columbia Metropolitan
Sun 7/12
6:25 am-7:52 am
Nonstop2h 27m
$269
ChicagoColumbia
ORD - CAE
ORDCAE
Chicago O'Hare Intl
Fri 7/3
7:10 am-10:28 am
Nonstop2h 18m
Columbia Metropolitan
Thu 7/9
6:25 am-7:52 am
Nonstop2h 27m
$269
ChicagoColumbia
ORD - CAE
ORDCAE
Chicago O'Hare Intl
Wed 8/5
5:55 pm-9:16 pm
Nonstop2h 21m
Columbia Metropolitan
Mon 8/10
6:25 am-7:52 am
Nonstop2h 27m
$269
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Fri 7/17
6:17 pm-9:26 pm
Nonstop2h 09m
Greenville
Mon 7/20
5:43 pm-7:00 pm
Nonstop2h 17m
$269
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
Fri 11/6
10:15 am-8:15 pm
2 stops9h 00m
Charlotte Douglas
Tue 11/10
11:00 am-5:45 pm
2 stops7h 45m
$276
ChicagoSavannah
MDW - SAV
MDWSAV
Chicago Midway
Wed 7/22
11:50 am-8:40 pm
2 stops7h 50m
Savannah/Hilton Head
Tue 7/28
7:50 am-2:05 pm
2 stops7h 15m
$277
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Tue 7/14
6:15 pm-9:29 pm
Nonstop2h 14m
Charlotte Douglas
Tue 7/21
6:00 am-9:36 am
1 stop4h 36m
$279
ChicagoColumbia
ORD - CAE
ORDCAE
Chicago O'Hare Intl
Tue 8/4
5:30 am-11:09 am
1 stop4h 39m
Columbia Metropolitan
Sun 8/9
1:59 pm-6:49 pm
1 stop5h 50m
$289
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
ORD-MYR
MDW-CLT
ORD-CHS
ORD-CAE
MDW-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
ORD-MYR
MDW-CLT
ORD-CHS
ORD-CAE
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $101). Flying from Chicago to South Carolina in September is currently the most expensive (average of $1,766). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 15, 2026.
It’s typically best to fly out from Chicago to South Carolina in the afternoon. Doing so could potentially save you 15% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 15, 2026.
The most flights from CHI to USSC are scheduled on a Sunday (25 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (19 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
How far ahead should I book a flight from Chicago to South Carolina?
The price you pay for your flight from Chicago to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on June 13, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 15, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 4 airlines flying from Chicago to South Carolina
Discover the top 4 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$146 | Average$288 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$153 | Average$400 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$202 | Average$369 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$205 | Average$382 | FlexibilityNo cancel fee | On-time69% |