$89+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:11 am -
1 stop25h 02m
Tue 10/134:03 pm -
1 stop24h 27m
Deal found 9/17![Multiple Airlines logo]()
$240
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:50 am -
1 stop5h 20m
Sat 10/104:58 pm -
Nonstop2h 32m
Deal found 9/17![United Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:51 am -
1 stop21h 47m
Wed 11/117:52 pm -
1 stop20h 45m
Deal found 9/17![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:11 am -
1 stop25h 02m
Tue 10/204:03 pm -
1 stop24h 27m
Deal found 9/18![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
1 stop24h 09m
Tue 11/34:08 pm -
2 stops21h 43m
Deal found 9/18![Multiple Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:55 am -
Nonstop2h 21m
Sat 10/2410:38 am -
1 stop6h 55m
Deal found 9/17![United Airlines logo]()
$253
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:50 am -
1 stop5h 20m
Sat 10/317:52 pm -
1 stop5h 09m
Deal found 9/17![United Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
1 stop24h 09m
Sat 10/242:42 pm -
2 stops10h 47m
Deal found 9/17![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:46 am -
1 stop22h 52m
Wed 10/286:00 am -
2 stops13h 16m
Deal found 9/18![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:15 am -
2 stops25h 33m
Wed 11/117:52 pm -
1 stop20h 45m
Deal found 9/18![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:04 am -
2 stops27h 10m
Wed 10/282:42 pm -
1 stop25h 55m
Deal found 9/20![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops28h 14m
Thu 11/59:36 am -
1 stop14h 07m
Deal found 9/19![Multiple Airlines logo]()
$268
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am -
Nonstop2h 27m
Thu 10/156:00 am -
1 stop6h 48m
Deal found 9/17![United Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:02 am -
Nonstop2h 22m
Sat 11/141:55 pm -
Nonstop2h 42m
Deal found 9/19![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:27 am -
1 stop6h 51m
Mon 11/94:11 pm -
1 stop5h 38m
Deal found 9/21![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:35 am -
1 stop6h 35m
Mon 10/268:45 pm -
1 stop4h 10m
Deal found 9/21![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:00 am -
Nonstop2h 25m
Sat 10/248:00 am -
Nonstop2h 32m
Deal found 9/19![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/101:05 pm -
1 stop5h 13m
Wed 11/1111:19 am -
1 stop5h 59m
Deal found 9/21![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:45 pm -
2 stops7h 00m
Tue 10/61:25 pm -
1 stop6h 55m
Deal found 9/17![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:00 am -
1 stop5h 05m
Sat 10/3110:55 am -
1 stop6h 13m
Deal found 9/17![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:35 am -
Nonstop2h 35m
Sat 10/242:51 pm -
Nonstop3h 14m
Deal found 9/21![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:04 am -
1 stop4h 10m
Sun 11/157:55 pm -
1 stop4h 59m
Deal found 9/21![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:45 pm -
Nonstop2h 05m
Mon 11/166:25 pm -
1 stop5h 20m
Deal found 9/21![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:32 pm -
Nonstop2h 34m
Mon 11/97:00 pm -
Nonstop2h 40m
Deal found 9/18![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/306:00 am -
1 stop4h 12m
Sat 2/65:10 pm -
1 stop6h 00m
Deal found 9/19![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops7h 10m
Tue 11/102:50 pm -
1 stop5h 05m
Deal found 9/18![Southwest logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:00 am -
1 stop7h 10m
Sun 11/155:54 pm -
1 stop5h 38m
Deal found 9/20![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:29 am -
Nonstop2h 17m
Mon 10/1210:22 am -
Nonstop2h 34m
Deal found 9/19![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:00 am -
1 stop4h 08m
Sun 12/137:00 am -
1 stop6h 04m
Deal found 9/20![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:30 am -
2 stops8h 15m
Mon 12/711:20 am -
2 stops8h 05m
Deal found 9/19![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:29 am -
Nonstop2h 17m
Tue 10/136:15 am -
Nonstop2h 31m
Deal found 9/18![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:04 am -
1 stop6h 10m
Mon 11/97:55 pm -
1 stop3h 59m
Deal found 9/20![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:45 pm -
1 stop5h 50m
Fri 12/116:35 am -
2 stops10h 10m
Deal found 9/19![Southwest logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:17 pm -
Nonstop2h 00m
Tue 10/136:20 am -
Nonstop2h 09m
Deal found 9/22![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:04 am -
1 stop6h 10m
Mon 11/25:11 pm -
1 stop6h 22m
Deal found 9/20![Delta logo]()
$339
This KAYAK deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:54 pm -
Nonstop2h 06m
Thu 10/156:01 am -
Nonstop2h 21m
Deal found 9/21![American Airlines logo]()
$466
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/253:00 pm -
2 stops6h 55m
Wed 10/281:25 pm -
2 stops9h 35m
Deal found 9/20![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop4h 08m
Thu 11/265:44 pm -
1 stop6h 10m
Deal found 9/22![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:00 pm -
1 stop7h 15m
Sat 10/2411:28 am -
Nonstop2h 32m
Deal found 9/21![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:50 am -
1 stop4h 36m
Sat 10/1010:29 am -
Nonstop2h 30m
Deal found 9/19![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:00 pm -
2 stops8h 05m
Sat 10/105:35 pm -
1 stop5h 10m
Deal found 9/21![Southwest logo]()
$384
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:27 am -
1 stop4h 16m
Tue 10/131:59 pm -
1 stop6h 12m
Deal found 9/18![Delta logo]()
$359
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated September 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:11 am -
1 stop25h 02m
Tue 10/134:03 pm -
1 stop24h 27m
Deal found 9/17![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:11 am -
1 stop25h 02m
Tue 10/204:03 pm -
1 stop24h 27m
Deal found 9/18![Multiple Airlines logo]()
$247
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:50 am -
1 stop5h 20m
Sat 10/104:58 pm -
Nonstop2h 32m
Deal found 9/17![United Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
1 stop24h 09m
Tue 11/34:08 pm -
2 stops21h 43m
Deal found 9/18![Multiple Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:55 am -
Nonstop2h 21m
Sat 10/2410:38 am -
1 stop6h 55m
Deal found 9/17![United Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
1 stop24h 09m
Sat 10/242:42 pm -
2 stops10h 47m
Deal found 9/17![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:46 am -
1 stop22h 52m
Wed 10/286:00 am -
2 stops13h 16m
Deal found 9/18![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
2 stops28h 20m
Wed 10/213:42 pm -
1 stop16h 49m
Deal found 9/18![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:04 am -
2 stops27h 10m
Wed 10/282:42 pm -
1 stop25h 55m
Deal found 9/20![Multiple Airlines logo]()
$266
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:50 am -
1 stop5h 20m
Sat 10/317:52 pm -
1 stop5h 09m
Deal found 9/17![United Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops28h 14m
Thu 11/59:36 am -
1 stop14h 07m
Deal found 9/19![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
1 stop10h 12m
Tue 11/33:00 pm -
2 stops22h 51m
Deal found 9/21![Multiple Airlines logo]()
$268
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:41 pm -
1 stop15h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:00 am -
1 stop10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
1 stop24h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
2 stops28h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$110
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:47 am -
Nonstop2h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
1 stop10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:00 am -
1 stop24h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
1 stop23h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/148:00 am -
1 stop27h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:10 am -
1 stop26h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:04 am -
2 stops34h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:04 am -
1 stop24h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$129
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $240 (Kiwi.com) |
One-way from | $89 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $329 |
Good round-trip deal | $254 or less |
Good one-way deal | $149 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Wed 12/16
8:52 am-3:07 pm
1 stop5h 15m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$127
ChicagoMyrtle Beach
MDW Chicago Midway - MYR Myrtle Beach Intl
MDWMYR
Chicago Midway
Wed 12/16
12:50 pm-6:25 pm
1 stop4h 35m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$132
ChicagoMyrtle Beach
MDW Chicago Midway - MYR Myrtle Beach Intl
MDWMYR
Chicago Midway
Tue 12/15
1:02 pm-6:04 pm
1 stop4h 02m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Tue 10/13
5:27 am-11:35 am
1 stop5h 08m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Wed 12/16
6:00 am-11:50 am
1 stop4h 50m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$146
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Tue 12/15
10:38 am-2:00 pm
Nonstop2h 22m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$157
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Mon 10/19
12:55 pm-4:05 pm
Nonstop2h 10m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$159
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Tue 11/3
7:47 am-11:21 am
Nonstop2h 34m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$159
ChicagoCharleston
MDW Chicago Midway - CHS Charleston
MDWCHS
Chicago Midway
Wed 11/18
1:25 pm-4:30 pm
Nonstop2h 05m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$159
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Wed 12/16
8:04 am-3:10 pm
1 stop6h 06m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$169
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
ORD-MYR
ORD-CHS
ORD-GSP
MDW-MYR
ORD-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
ORD-MYR
ORD-CHS
ORD-GSP
MDW-MYR
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $348). Flying from Chicago to South Carolina in March is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 22, 2026.
It’s typically best to fly out from Chicago to South Carolina in the evening. Doing so could potentially save you 17% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 22, 2026.
The most flights from CHI to USSC are scheduled on a Monday (20 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
Airfare is below average for this route at the moment.
Chicago to South Carolina flights typically cost between $286 and $476 in October.The cheapest round-trip price found within the last 5 days was $243 on United Airlines (Oct 7-Oct 10).
How far ahead should I book a flight from Chicago to South Carolina?
The price you pay for your flight from Chicago to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on September 19, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Sunday afternoons when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 22, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 4 airlines flying from Chicago to South Carolina
Discover the top 4 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$334 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$209 | Average$375 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$209 | Average$394 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$244 | Average$421 | FlexibilityNo cancel fee | On-time63% |